---
slug: fn-prec-06-ly-et-al-2018-psychedelics-and-neural-plasticity
title: "Ly et al. (2018) — psychedelics and neural plasticity"
kind: precedent
status: published
hash: 47a1394621a37ece2774cc9489d5bb1460f8c46b184b31d1398055b3a94ad2e3
created: 2026-10-11T07:07:16.588Z
updated: 2026-10-11T07:07:16.588Z
summary: ""
tags: []
above: ["[[fn-index-precedents]]"]
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adjacent: []
nested: []
---
# Ly et al. (2018) — psychedelics and neural plasticity

Citation: Ly C, Greb AC, Cameron LP, Wong JM, Barragan EV, Wilson PC, Burbach KF, Soltanzadeh Zarandi S, Sood A, Paddy MR, Duim WC, Dennis MY, McAllister AK, Ori-McKenney KM, Gray JA, Olson DE. "Psychedelics promote structural and functional neural plasticity." *Cell Reports* 23(11):3170–3182 (2018). License: CC BY-NC-ND (Europe PMC record); PMC6082376.

Identifiers: PMID 29898390; DOI 10.1016/j.celrep.2018.05.022.

Retrieved from: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=29898390&rettype=abstract&retmode=xml (record also at https://pubmed.ncbi.nlm.nih.gov/29898390/)

Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast-acting antidepressant properties of the dissociative anesthetic ketamine. Here, we report that, like ketamine, serotonergic psychedelics are capable of robustly increasing neuritogenesis and/or spinogenesis both in vitro and in vivo. These changes in neuronal structure are accompanied by increased synapse number and function, as measured by fluorescence microscopy and electrophysiology. The structural changes induced by psychedelics appear to result from stimulation of the TrkB, mTOR, and 5-HT2A signaling pathways and could possibly explain the clinical effectiveness of these compounds. Our results underscore the therapeutic potential of psychedelics and, importantly, identify several lead scaffolds for medicinal chemistry efforts focused on developing plasticity-promoting compounds as safe, effective, and fast-acting treatments for depression and related disorders.

## Facts

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  "kind": "precedent",
  "citation": "Ly C, Greb AC, Cameron LP, Wong JM, Barragan EV, Wilson PC, Burbach KF, Soltanzadeh Zarandi S, Sood A, Paddy MR, Duim WC, Dennis MY, McAllister AK, Ori-McKenney KM, Gray JA, Olson DE. \"Psychedelics promote structural and functional neural plasticity.\" *Cell Reports* 23(11):3170–3182 (2018). License: CC BY-NC-ND (Europe PMC record); PMC6082376.",
  "identifiers": "PMID 29898390; DOI 10.1016/j.celrep.2018.05.022.",
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```

---

**above:** [[fn-index-precedents]]