foxo4 dri

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1. FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway
   “Injection of FOXO4-DRI in both naturally aged and induced aging mice effectively suppressed aortic aging and improved aortic function.”
2. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
   “This study reveals structural insights into p53 binding to FOXO4/ FOXO4-DRI , informing the development of p53-targeted senolytics for age related diseases.”
3. FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation
   “FOXO4-DRI shows potential as a treatment targeting the senescence and apoptosis resistance, and holds promise as an approach to prevent the ...”
4. FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells
   “In naturally aged mice, FOXO4-DRI -treated aged mice exhibited increased sperm quality and improved spermatogenesis.”
5. Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline.
   “In aged mammalian models, administering FOXO4-DRI decreases the accumulation of senescent cells, restores cerebral blood flow and the integrity...”