glutathione

Sources

1. Exploring the Safety and Efficacy of Glutathione Supplementation for Skin Lightening: A Narrative Review
   “This narrative review aims to evaluate the efficacy and safety of oral, topical, and intravenous glutathione in skin-lightening therapies.”
2. Glutathione in Skin Aging and Tissue Regeneration: A Systematic Review of Molecular Mechanisms, Redox Modulation, and Biomedical Implications
   “This systematic review evaluated molecular, clinical, and translational evidence of glutathione's applications and safety across different delivery modalities.”
3. A Literature Review of Glutathione Therapy in Ameliorating Hepatic Dysfunction in Non-Alcoholic Fatty Liver Disease
   “This literature review examines studies from 2014-2024 exploring GSH therapy in NAFLD patients.”
4. Systematic Review of the Efficacy and Safety of Topical Glutathione in Dermatology
   “Five clinical trials met the inclusion criteria. Results: Studies suggest glutathione may improve hyperpigmentation and provide antioxidant advantages.”
5. A Targeted Metabolomic Assessment of Oral Glutathione Bioavailability and Safety in Humans: A Randomized Crossover Clinical Trial
   “This human pilot study aimed to evaluate the oral absorption and safety profile of a novel formulation of micellar glutathione (LipoMicel ® , LMG) compared with two commonly used dietary supplement forms.”
6. Liposomal glutathione outperforms plain glutathione in uptake, cell regeneration and systemic availability: evidence from cellular and human models
   “LipoDuo™ Glutathione significantly improves cellular delivery, biological activity and systemic bioavailability compared with conventional glutathione. Its bimodal distribution and prolonged plasma retention position it as a next-generation antioxidant supplement with clinical potential in oxidative stress management, skin health and metabolic recovery.”
7. Brain Glutathione Levels Associate With Cognitive Function in Healthy Aging
   “Glutathione (GSH), the brain's primary endogenous antioxidant, is integral to the cerebral antioxidant defense system and essential for maintaining redox balance.”
8. Hepatic glutathione depletion ameliorates MASLD through modulation of lipid metabolism and inflammation
   “Glutathione (GSH) maintains a reduced cellular environment and is widely believed to mitigate disease-associated oxidative damage to proteins, lipids, and DNA.”
9. Glutathione and neurodegenerative diseases
   “Glutathione (GSH), a key regulator of oxidative stress and cellular immunity, has a critical role in modulating the functional states of CNS-resident and infiltrating immune cells.”
10. Creatine plus β-Hydroxy-β-Methylbutyrate supplementation is associated with preserved glutathione redox-balance and redox-function associations in older adults: a secondary analysis of a randomized crossover trial
    “Supplementation was associated with attenuation of the placebo-related increase in oxidized glutathione and nominal preservation of the Glutathione Redox Index, although these effects did not remain significant after FDR adjustment.”
11. Catabolism of extracellular glutathione supplies cysteine to support tumours
    “Our findings indicate a non-canonical role for GSH in supporting tumours by acting as a reservoir of amino acids. Depriving tumours of extracellular GSH or inhibiting its breakdown is potentially a therapeutically tractable approach for patients with cancer.”
12. Efficacy and Safety of Glutathione Supplementation in HIV Infection and HIV-Tuberculosis Co-Infection: A Systematic Review
    “This review examines the efficacy and safety of glutathione supplementation and precursor-based strategies in HIV infection and HIV-tuberculosis co-infection.”
13. Glutathione as a Potential Neuroprotectant Against MDMA-Induced Oxidative Stress, Neuroinflammation, and Apoptosis in the Rat Brain
    “Co-administration of glutathione at low MDMA doses ameliorated these effects, restoring antioxidant defenses, suppressing inflammation, and preserving hippocampal architecture. However, its protective efficacy was notably diminished at higher MDMA concentrations.”
14. Phospholipid Glutathione Peroxidase Overexpression Mitigates Cancer Cachexia by Protecting Muscle Mass and Lowering Inflammation
    “Our results show that GPx4 overexpression protected muscle mass and mitochondrial respiration in tumour-bearing mice, possibly by reducing muscle inflammation and oxidative stress.”
15. Is Higher Antioxidant Capacity an Important Determinant of Cognitive Resilience in Aging?
    “Glutathione is a major component of the cellular antioxidant system, providing a means of controlling redox homeostasis and affording protection.”