humanin

Sources

1. A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders
   “The review primarily highlights that HN is an autophagy inducer, which can promote cell survival in the presence of metabolic and oxidative stress, ...”
2. The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects
   “It has a neuroprotective effect against Alzheimer's disease (AD) and other neurodegenerative diseases by improving hippocampal acetylcholine.”
3. Humanin improves bone health in a glucocorticoid-treated mouse model
   “We investigated whether the mitochondrial peptide humanin (HNG) could prevent GC-induced growth retardation and osteoporosis in mouse models of ...”
4. Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine ...
   “Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine ...”
5. Humanin variant P3S is associated with longevity in APOE4 carriers
   “Our research uncovered a unique humanin variant, P3S, specifically enriched in centenarians with the APOE4 allele.”
6. Humanin variants aggregate to produce different fibril structures with distinct cytotoxicity
   “Humanin is an endogenous human peptide with cytoprotective effects, including inhibition of apoptosis via interaction with BCL-2 proteins such as BAX.”
7. Insights into the Biomarker Potential of Humanin and Mots-c in Metabolic and Neurodegenerative Diseases
   “Humanin (HN) and MOTS-c are mitochondrial-derived peptides (MDPs) known for their neuroprotective and metabolic functions. Their circulating and tissue levels...”
8. HUMANIN produced by human efferocytic macrophages promotes inflammation resolution
   “Mainly known for its antioxidant and neuroprotective effects, we found that HUMANIN was also associated with pro-resolving properties in human and mouse models.”
9. Redox-sensitive miRNAs and Humanin could mediate the metabolic benefits of crocin and astaxanthin in type 2 diabetes
   “The metabolic and anti-inflammatory benefits of CT and AST in T2DM may mediated by the effects of HN on mitochondrial function and insulin signaling...”
10. Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction
    “Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction”
11. Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE
    “To investigate Humanin and SHMOOSE... as potential mitochondrial biomarkers of Med-Diet adherence and their associations with markers of oxidative stress.”
12. Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Mortality and Morbidity Prediction
    “In this study, we evaluated whether circulating levels of Humanin, a micropeptide reflecting mitochondrial dysfunction, could refine CVMM prediction...”
13. Mitochondrial-derived peptides MOTS-c and humanin attenuate glucocorticoid-induced muscle atrophy
    “Glucocorticoids... cause severe muscle wasting. Mitochondrial-derived peptides (MDPs) are promising...”
14. Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome
    “Keywords: Androgen excess; Humanin; Insulin resistance; Mitochondrial dysfunction; Mitokine; PCOS.”
15. Mitochondrial-Derived Peptides as Therapeutics and Biomarkers in Vascular Diseases
    “This review examines the protective roles of mitochondrial-derived peptides such as humanin, MOTS-c, and small humanin-like peptides in mitigating vascular...”