Evidence review · standard

mk 677

bundle · json · system map · manifest

Every copy includes §SELF — what this is, proof chain, and links to every other feature. No context required.

§SELF — this page explains the system
## §SELF — miscsubjects (paste without context)

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `human_page` — **Human article page**
Rendered article with claims, sources, copy widgets, ask prompts.
- **article slug:** `mk-677`
- **contains:** rendered article, copy widgets, claims, sources, ask prompts
- **how to use:** Use Copy for LLM or Copy system map — both paste without context.
- **read:** https://miscsubjects.com/a/mk-677

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/mk-677/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **bundle** — Paste-ready package: body + claims + sources + voxels + provenance + manifest + constitution. · https://miscsubjects.com/api/articles/mk-677/bundle?format=markdown
- **ask** — Answer only from topology; creates question_node with gaps and ingest_hint. · https://miscsubjects.com/api/articles/mk-677/prompts
- **topology** — Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER. · https://miscsubjects.com/api/articles/mk-677/topology

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

*Not medical advice. Tier-honest. Cite claim/source ids.*

Regeneration vs degeneration — where this fits

The body is always doing two things at once: breaking down (degeneration) and building back (regeneration). A condition persists when breakdown outruns repair. Most drugs used for symptoms suppress a signal (pain, acid, anxiety, inflammation) without fixing the tissue that caused the signal. Peptides in this ledger are studied for repair pathways: new blood vessels, repair-cell migration, nerve regrowth, gut lining, neural connections. This article maps one compound through that frame — what it is, how it is proposed to work, what evidence exists, and what people report.

What it is

2025 BMJ Case Reports case study documenting reversible hepatotoxicity (transaminitis) in a healthy man after 2 months of MK-677 use. 2025 Drug Testing and Analysis GEON network study of 324 seized illegal products; ibutamoren (MK-677) was the most frequently reported GHS in performance-enhancing medicines/supplements.

How it works

From preclinical claims (animal/lab — not human proof):

  1. 2025 BMJ Case Reports case study documenting reversible hepatotoxicity (transaminitis) in a healthy man after 2 months of MK-677 use.
  2. 2025 Drug Testing and Analysis GEON network study of 324 seized illegal products; ibutamoren (MK-677) was the most frequently reported GHS in performance-enhancing medicines/supplements.

Why it would work (logic chain)

  1. IF 2025 BMJ Case Reports case study documenting reversible hepatotoxicity (transaminitis) in a healthy man after 2 months of MK-677 use. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  2. IF 2025 Drug Testing and Analysis GEON network study of 324 seized illegal products; ibutamoren (MK-677) was the most frequently reported GHS in performance-enhancing medicines/supplements. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  3. IF 2026 Clinica Chimica Acta study establishing hair incorporation levels of ibutamoren/MK-677 after single 10mg dose (1.3 pg/mg) and chronic use (224 pg/mg), relevant for doping detection. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).

How many people take it

There is no reliable global count of how many people take this compound. That number is not in this ledger.

What we can count from this ledger:

  • 0 anecdote source(s) (posts, threads, comments)
  • 0 anecdote-tier claim(s) derived from them

Logic: Without catalogued Reddit/X posts, this article cannot answer how many people take it — only what studies exist.

Evidence inventory

This is a count of what is in this ledger — not a claim about all research worldwide.

  • Scientific sources catalogued (PubMed, trials, reviews): 3
  • Claims tagged human evidence: 1
  • Claims tagged preclinical (animal/lab): 2
  • Claims tagged anecdotal: 0
  • Reddit posts catalogued: 0
  • X posts catalogued: 0
  • Other anecdote sources (YouTube, Instagram, etc.): 0
  • Total sources in chain: 3

Logic: No social posts catalogued yet — we cannot report what people are saying on Reddit or X from this ledger.

Quantified confidence (this ledger): 0.28 / 1.00 — low — animal and anecdote heavy

Formula: human claims×0.12 + preclinical×0.04 + anecdote×0.015 + studies (capped). This is not clinical certainty — it measures how much graded evidence is catalogued here.

What scientists say

Hepatotoxicity induced by MK-677 (source s1)

2025 BMJ Case Reports case study documenting reversible hepatotoxicity (transaminitis) in a healthy man after 2 months of MK-677 use.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

Knowing the minimal detectable dose can facilitate the interpretation of a hair test result: II. Case example with ibutamoren (MK-677), a growth hormone secretagogue (source s2)

2026 Clinica Chimica Acta study establishing hair incorporation levels of ibutamoren/MK-677 after single 10mg dose (1.3 pg/mg) and chronic use (224 pg/mg), relevant for doping detection.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

SARMs, Metabolic Modulators and Growth Hormone Secretagogues in Suspected Illegal Medicines, Bought as Sport Performance Enhancers: A Retro- and Prospective Study Within the GEON (source s3)

2025 Drug Testing and Analysis GEON network study of 324 seized illegal products; ibutamoren (MK-677) was the most frequently reported GHS in performance-enhancing medicines/supplements.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

---

Not medical advice. Counts and quotes are from this article's hash-chained ledger. Anecdote = real reports, not proof. Animal studies ≠ human proof.

Mk 677 · peptide map

Evidence map

Hover a node — its path lights up. Click to open the article.

Full map →
JumpBenzo WithdrawalBenzodiazepinesBrain FogCarpal Tunnel
Evidence · 3 sources · swipe →chain 63b89a7e2c08 · verify chain · provenance
1 / 3
Evidence ledger 3 · tier-ranked · API
preclinical
2025 BMJ Case Reports case study documenting reversible hepatotoxicity (transaminitis) in a healthy man after 2 months of MK-677 use.
sources: s1
preclinical
2025 Drug Testing and Analysis GEON network study of 324 seized illegal products; ibutamoren (MK-677) was the most frequently reported GHS in performance-enhancing medicines/supplements.
sources: s3
humanlow confidence
2026 Clinica Chimica Acta study establishing hair incorporation levels of ibutamoren/MK-677 after single 10mg dose (1.3 pg/mg) and chronic use (224 pg/mg), relevant for doping detection.
sources: s2
Model swipes · 2 from 1 model · swipe →verify
1 / 2
grok-4.3writer
draft2026-06-29 17:05
mk 677
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: mk-677
it output
3 source(s) added
eff54e70ff84d891
grok-4.3source_hunt
sources2026-06-29 17:05
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: mk-677
it output
3 source(s) added
bb0294b3756e7246

Related research

Mk 677 · peptide map

Open evidence map →
Benzo Withdrawalmk-677-benzo-withdrawalBenzodiazepinesmk-677-benzodiazepinesBrain Fogmk-677-brain-fogCarpal Tunnelmk-677-carpal-tunnelChemomk-677-chemoChemo Neuropathymk-677-chemo-neuropathyCognitionmk-677-cognitionCorticosteroidsmk-677-corticosteroidsDiabetic Neuropathymk-677-diabetic-neuropathyFrozen Shouldermk-677-frozen-shoulder
Ask this article · 5 suggested prompts
topology · JSON · question graph

Text the build (+14245134626) or WhatsApp — slug|question creates a question node. Paste evidence with ingest slug|q:NODE_ID|your paste.

What does the ledger say about this (preclinical tier): "2025 BMJ Case Reports case study documenting reversible hepatotoxicity (transaminitis) in a healthy man after 2 months of MK-677 use."?
ask mk-677 claim c1 · paste includes §SELF
What does the ledger say about this (preclinical tier): "2025 Drug Testing and Analysis GEON network study of 324 seized illegal products; ibutamoren (MK-677) was the most frequently reported GHS i…"?
ask mk-677 claim c3 · paste includes §SELF
What does the ledger say about this (human tier): "2026 Clinica Chimica Acta study establishing hair incorporation levels of ibutamoren/MK-677 after single 10mg dose (1.3 pg/mg) and chronic u…"?
ask mk-677 claim c2 · paste includes §SELF
For my medical situation, what can you answer from your catalogue about mk 677 — and what would you need me to tell you first?
ask mk-677 condition gaps · paste includes §SELF
What good and bad outcomes are documented for mk 677 (studies vs anecdotes)?
ask mk-677 good bad experiences · paste includes §SELF
Add your experience or question
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