---
slug: mots-c
title: "mots c"
kind: standard
status: published
hash: b664b9c080e9d6188858c7f00ae3c2a296522ee1b39b5954c352fe259dc4d248
created: 2026-06-29T16:49:17.986Z
updated: 2026-10-08T11:50:03.613Z
summary: "Evidence is being populated by Grok web"
tags: []
above: []
below: []
adjacent: []
nested: []
---
# mots c

*Evidence is being populated by Grok web*

## Overview
Evidence is being populated by Grok web search.

## Facts

```json
{
  "converted_from": "markdown",
  "original_updated": "2026-06-29T16:49:41.847Z",
  "register": "standard",
  "category": null
}
```

## Sources

1. [MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity (MOTS-MET)](https://clinicaltrials.gov/study/NCT07505745) — “This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity.” (sha256 f86f069ded0af4ab)
2. [MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner](https://pubmed.ncbi.nlm.nih.gov/41520850/) — “We demonstrate, using two distinct transgenic mouse strains, that administration of MOTS-c augments muscle mitochondrial bioenergetic performance through reliance on both the transcriptional coactivator, Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), and cellular energy-sensing kinase, 5' adenosine monophosphate-activated protein kinase (AMPK).” (sha256 23b7f76964d59ac4)
3. [Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss](https://pubmed.ncbi.nlm.nih.gov/41551324/) — “Circulating MOTS-c levels were significantly higher in obese compared to lean individuals (273 ± 56 vs.” (sha256 c5bd2c876e7cfe83)
4. [Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with type 2 diabetes mellitus](https://pmc.ncbi.nlm.nih.gov/articles/PMC12174021/) — “Recent research has identified the mitochondrial open reading frame of the 12S rRNA-c ( MOTS-c ) as a crucial mitochondrial peptide that significantly influences ...” (sha256 d54170784f7e2a21)
5. [Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes](https://pubmed.ncbi.nlm.nih.gov/40855115/) — “Our findings suggest that mitochondrial-encoded MOTS-c regulate pancreatic islet cell senescence and that MOTS-c could act as a senotherapeutic agent to prevent pancreatic islet cell senescence and diabetes progression.” (sha256 77dcddd10422bea6)
6. [Exploring the therapeutic potential of MOTS-c in age-related macular degeneration](https://pubmed.ncbi.nlm.nih.gov/39961901/) — “The MOTS-c peptide appears to enhance cellular metabolism and regulate gene expression, which could potentially provide therapeutic benefits in AMD.” (sha256 c864756dacd21f87)
7. [Endurance training enhances skeletal muscle mitochondrial respiration by promoting MOTS-c secretion](https://pubmed.ncbi.nlm.nih.gov/39706498/) — “More importantly, we found that endurance training may enhance the mitochondrial respiratory function of skeletal muscle by promoting the secretion of MOTS-c and activating the AMPK/PGC-1α pathway.” (sha256 9c35028037e71c8c)
8. [Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea](https://pubmed.ncbi.nlm.nih.gov/40538389/) — “Recent research has identified the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) as a crucial mitochondrial peptide that significantly influences metabolic regulation, mimics the effects of exercise, and mitigates oxidative stress.” (sha256 fc42d879deeb2d1a)