---
slug: pt-141-ssri-sexual-dysfunction
title: "PT-141 for SSRI-Induced Sexual Dysfunction: Evidence-Graded Review"
kind: source_ledger
status: published
hash: 43ddff1be60a8730c73a6d47164f7441a5dac417881413c76d5303edbcbadecc
created: 2026-06-29T13:23:09.522Z
updated: 2026-10-08T11:50:45.841Z
summary: "SSRIs are linked to loss of libido, anorgasmia, and erectile dysfunction in clinical observations (human tier). Prevalence estimates range 25-73% depending on specific agent and population (human tier). PT-141 (bremelanotide) is a"
tags: []
above: []
below: []
adjacent: []
nested: []
---
# PT-141 for SSRI-Induced Sexual Dysfunction: Evidence-Graded Review

*SSRIs are linked to loss of libido, anorgasmia, and erectile dysfunction in clinical observations (human tier). Prevalence estimates range 25-73% depending on specific agent and population (human tier). PT-141 (bremelanotide) is a*

## SSRI-Associated Sexual Dysfunction
SSRIs are linked to loss of libido, anorgasmia, and erectile dysfunction in clinical observations (human tier). Prevalence estimates range 25-73% depending on specific agent and population (human tier).

## PT-141 Mechanism
PT-141 (bremelanotide) is a melanocortin receptor agonist that acts at brain-level pathways associated with sexual arousal and desire (mechanistic tier). It selectively activates MC4R in the central nervous system (mechanistic tier).

Vyleesi (bremelanotide) received FDA approval in 2019 for acquired, generalized HSDD in premenopausal women; the mechanism by which it improves HSDD is unknown but believed to involve melanocortin receptors in the CNS (human tier).

## Mapping to SSRI Effects
No approved indication exists for medication-induced sexual dysfunction (human tier). Human trials of bremelanotide focused on primary HSDD, not SSRI-induced cases (human tier).

Preclinical (rat) studies showed melanocortin agonists initiate penile erections and enhance sexual behavior (preclinical tier).

## Human Trial Data
Phase 3 placebo-controlled trials (Studies 301/302) in premenopausal women with HSDD demonstrated statistically significant improvements in sexual desire scores and reductions in distress versus placebo (human tier).

Earlier studies explored intranasal PT-141 in men with ED, including sildenafil non-responders, reporting dose-dependent improvements in erectile function scores (human tier).

## Novelty and Framing
PT-141 represents a centrally acting approach via melanocortin pathways rather than peripheral suppression or hormonal modulation (mechanistic tier). No human data directly address repair versus suppression in SSRI contexts (no human data).

User reports on forums remain anecdotal and unverified for this specific application (anecdotal tier).

---

Related:
[PT-141](/a/pt-141)

![[pt-141]]

## Facts

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  "category": null
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## Sources

1. [Antidepressant-associated sexual dysfunction: impact, effects and treatment](https://pmc.ncbi.nlm.nih.gov/articles/PMC3108697/) — “Studies estimate that the incidence varies from 30% of people treated with imipramine to 25%–73% of people treated with an SSRI” (sha256 9d8891d48c20f00e)
2. [Bremelanotide: Uses, Interactions, Mechanism of Action](https://go.drugbank.com/drugs/DB11653) — “The mechanism by which bremelanotide's action on receptors translates to a clinical effect is still unknown.” (sha256 5880a59d4feaa26c)
3. [Bremelanotide: First Approval](https://pubmed.ncbi.nlm.nih.gov/31429064/) — “Bremelanotide is a synthetic peptide analogue of the neuropeptide hormone alpha melanocyte-stimulating hormone (α-MSH) with high affinity for the melanocortin type 4 receptor (thought to be important for sexual function)” (sha256 6c7cf75e14f78c41)
4. [FDA Approves New Drug Application for Vyleesi](https://palatin.com/press_releases/fda-approves-new-drug-application-for-vyleesi-bremelanotide-injection-2/) — “While the exact mechanism of action is unknown, Vyleesi is believed to bind to melanocortin receptors in the central nervous system that are thought to be associated with sexual function.” (sha256 c08c3487cc48d5fc)
5. [Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder](https://pmc.ncbi.nlm.nih.gov/articles/PMC6819021/) — “Both studies demonstrated that bremelanotide significantly improved sexual desire and related distress in premenopausal women with hypoactive sexual desire disorder” (sha256 48467f6748cce1c2)
6. [Antidepressant-Associated Sexual Dysfunction](https://www.netce.com/course/content/antidepressant-associated-sexual-dysfunction/95083/3266) — “these medications are specifically approved to treat low female sexual desire not the result of the effects of a medication, so their use in the management of antidepressant-associated sexual dysfunction is off-label.” (sha256 06930d013e6c82e0)
7. [Bremelanotide: A Psychiatric Perspective Bremelanotide (Vyleesi®): Reconceptualizing a Melanocortin Receptor Agonist as a Centrally-Acting Psychotropic Agent for the Management of Antidepressant-Induced Sexual Dysfunction](https://www.researchgate.net/publication/400299455_Bremelanotide_A_Psychiatric_Perspective_Bremelanotide_VyleesiR_Reconceptualizing_a_Melanocortin_Receptor_Agonist_as_a_Centrally-Acting_Psychotropic_Agent_for_the_Management_of_Antidepressant-Induced_S) — “This review examines the neurobiological mechanism of bremelanotide, presents evidence supporting its classification as a centrally-acting psychotropic agent, and proposes a rationale for its integration into psychiatric treatment algorithms for patients experiencing sexual dysfunction secondary to serotonergic antidepressant therapy.” (sha256 db9037f6c56a9148)
8. [Management of Antidepressant-Induced Sexual Dysfunction](https://pmc.ncbi.nlm.nih.gov/articles/PMC12433685/) — “... antidepressant-induced sexual dysfunction (AISD). An electronic ... SSRI-induced sexual dysfunction . Jacobsen PL, Mahableshwarkar AR ...” (sha256 7d9f1128a4fbf984)
9. [Everything recovered after SSRIs... except my erection. I'm ...](https://www.reddit.com/r/PSSD/comments/1oa1dne/everything_recovered_after_ssris_except_my/) — “Peptides ( PT-141 / Bremelanotide ): Some people say it's life-changing, others say it's useless. Some say it only gives erections without ...” (sha256 00efc978cba092fb)
10. [PT 141 for libido : r/Biohackers](https://www.reddit.com/r/Biohackers/comments/1c39lie/pt_141_for_libido/) — “PT 141 for libido . Sex has a very psychological component. SSRI's. My libido tanked permanently after SSRI's.” (sha256 3d4fdace89fd04d1)
11. [PT-141 and Female Sexual Dysfunction Research: Melanocortin Pathways, Desire and Central Arousal Mechanisms UK 2026](https://peptideslabuk.com/pt-141-and-female-sexual-dysfunction-research-melanocortin-pathways-desire-and-central-arousal-mechanisms-uk-2026/) — “Selective serotonin reuptake inhibitors (SSRIs) cause sexual dysfunction (delayed orgasm, reduced desire, anorgasmia) in 30–40% of users — through serotonin-mediated suppression of dopaminergic circuits (5-HT2A receptor activation suppresses mesolimbic dopamine release). PT-141’s pro-dopaminergic mechanism provides a pharmacological rationale for investigating whether MC4R activation can reverse SSRI-induced sexual dysfunction — a research question with substantial clinical r” (sha256 a96b2ca74153ee2e)
12. [PT-141 (Bremelanotide): The Independent Assessment](https://getpeptideclarity.com/compounds/pt-141) — “Off-label use for general sexual wellness, postmenopausal HSDD and SSRI-induced sexual dysfunction is reported in clinical practice. Some practitioners combine PT-141 with PDE5 inhibitors or low-dose testosterone for patients with multifactorial sexual dysfunction. Practitioner-reported outcomes suggest benefit in some patients, but the evidence base is thin and no controlled trials support these uses.” (sha256 c50572a0ad8baecd)
13. [Bremelanotide (PT-141) for Female Libido (another study ...)](https://www.reddit.com/r/psychologyofsex/comments/1qa5z8g/bremelanotide_pt141_for_female_libido_another/) — “It has been researched as a treatment for post- SSRI sexual dysfunction in ...” (sha256 8ee3971d538b3150)
14. [To Those Who Have Tried The "Sex-Peptide" PT-141](https://www.reddit.com/r/Biohackers/comments/1jdk15l/to_those_who_have_tried_the_sexpeptide_pt141_have/) — “PT-141 is a peptide that increases libido , sexual desire and erectile dysfunction- The peptide acts as a Melanocortin 4 receptor (MC4R) agonist to induce these ...” (sha256 ade9a193cadd2c7b)
15. [The combo of Tadalafil and PT-141 is insanely effective](https://www.reddit.com/r/erectiledysfunction/comments/1frnpj6/the_combo_of_tadalafil_and_pt141_is_insanely/) — “I too have taken SSRI and been badly affected by them. 20 years ago, but the problem never went away. PT-141 is expensive, and you can't use it very often, so it isn't an ideal solution just as you say. It's more of an occasional "party drug" you take if something special is about to go down.” (sha256 fe236bf885171408)
16. [PT-141 Myths Busted! The Truth About This Game-Changing Sex Peptide | Sexual Wellness Podcast](https://www.youtube.com/watch?v=deUV6eDsdTs) — “[@gmmq6882]: I was in a constant state of arousal once I started on pt-141. I would have an erection sometimes for 2 hours and you didn't know when it was going to take place like you said it could have been an hour after the injection or 5 hours so yes even while at work there were times when I could not get up to walk around because of an erection.” (sha256 3b9897ca3676c5d8)
17. [PT-141 Myths Busted! The Truth About This Game-Changing Sex Peptide | Sexual Wellness Podcast](https://www.youtube.com/watch?v=deUV6eDsdTs) — “[@gillyboy1566]: I have Multifactorial Ed And It is Severe, Pump Therapy gives significant pain I am Diabetic Heart Attach Stroke and On Incliziran For Cholesterol because Statins are Ineffective I bought this to try and I can tell you it had the Desire effect but the headache was not worth the result and i could not eat for 3 days due to feeling sick no nore for me i shall never have an erection again” (sha256 d53378eae127fc07)
18. [Looking for people who tried pt-141](https://www.reddit.com/r/PSSD/comments/1irm4qn/looking_for_people_who_tried_pt141/) — “Tried it a few times. I guess it does what it says help NO production but it wasnt really noticeable and not sustainable i think to be doing all the time for sex. Basically my fave was very flushed and ya i had sex but i also was susing cialis viagara aswell. It didnt effect my libido” (sha256 f88e39b8f8d4c26b)
19. [Looking for people who tried pt-141](https://www.reddit.com/r/PSSD/comments/1irm4qn/looking_for_people_who_tried_pt141/) — “For me pt-141 gave me super hard erections but did absolutely nothing for my libido/desire so it was just kind of robotic feeling. It also instantly would make me nauseous and extremely flushed no matter what the dose was. Overall it wasn’t worth it for me personally.” (sha256 efb7441811367a7f)
20. [Looking for people who tried pt-141](https://www.reddit.com/r/PSSD/comments/1irm4qn/looking_for_people_who_tried_pt141/) — “I’ve tried PT-141 several times. All I can say is that it gives you a very hard, sometimes painful erection that lasts for about 9 hours straight. The annoying part is that there’s no increase in sexual desire or arousal.” (sha256 146dc1eeabaa05f0)
21. [Pr 141 peptide](https://www.reddit.com/r/PSSD/comments/1d4of7t/pr_141_peptide/) — “Just started….works really well for me. I pin it 2+ hours before sex with FWB. Libido significantly increased and no ED (foreplay is still essential) Context: been off psych meds for 6 years.” (sha256 d08287be5d7f893b)
22. [PT 141](https://www.reddit.com/r/pssdhealing/comments/1siyei3/pt_141/) — “Tried 1 dose of peptide pt 141. Within minutes, i noticed flushing and warmth, but it went away in an hour. 3 to 4hrs later, i started having random, and very rigid erections. These random erections lasted for 12hrs... There was no increase in libido at all.” (sha256 ef687f9b5e5f1ea7)
23. [PT 141](https://www.reddit.com/r/pssdhealing/comments/1siyei3/pt_141/) — “Update: I've taken it twice now, and the second time, it really didn't do much. Gave me a few random boners, but they were like 75 percent. I've also noticed, that the next day i feel worn out and emotionally worse, some depression and slightly worse anhedonia. It goes away after a day or two. I have not noticed any increase in libido yet.” (sha256 ca423470ee8ebc43)
24. [Has anybody here ever tried taking PT-141 for PSSD symptoms?](https://www.reddit.com/r/PSSD/comments/12qjcq0/has_anybody_here_ever_tried_taking_pt141_for_pssd/) — “I've used it. It works. It's one of the things that's bringing relief to some people.” (sha256 f50bb9158ba3a7b5)
25. [Has anybody here ever tried taking PT-141 for PSSD symptoms?](https://www.reddit.com/r/PSSD/comments/12qjcq0/has_anybody_here_ever_tried_taking_pt141_for_pssd/) — “It does work for men and I have taken it. The problem is it causes nausea and all kinds of side effects for me. It will bring some temporary libido” (sha256 c981456d3fb28446)
26. [PT-141 and oxytocin combination experiences](https://x.com/BowTiedHRT/status/2070197193924034976) — “I have clients who love PT-141 on its own. ... For me and for the clients who respond well to it, that presents as genuinely improved erectile quality and a noticeable lift in arousal.” (sha256 f165d6205b73000d)
27. [PT-141 male enhancement and PSSD reboot](https://x.com/BowTiedUM/status/1756810573818569085) — “I've also seen it reboot sexual dysfunction and ED in people suffering from -PIED -Post SSRI Sexual Dysfunction - Post Finasteride Syndrome” (sha256 4c80277928ad2c93)
28. [Has anyone tried Vyleesi (Bremelanotid or pt 141)?](https://www.reddit.com/r/PSSD/comments/109wkbg/has_anyone_tried_vyleesi_bremelanotid_or_pt_141/) — “Yes I have. Its gives rock hard painful erections but does nothing for libido/sex drive. If you have sex on it, its mechanical and meaningless” (sha256 f227c8a6a1c8bad4)
29. [Has anyone tried Vyleesi (Bremelanotid or pt 141)?](https://www.reddit.com/r/PSSD/comments/109wkbg/has_anyone_tried_vyleesi_bremelanotid_or_pt_141/) — “Pt141 gave me drive and function but I felt like crap while on it and even for days after” (sha256 2903aeac4b9919a6)
30. [Has anyone tried pt 141 (bremelanotide)?](https://www.reddit.com/r/PSSD/comments/obx5ao/has_anyone_tried_pt_141_bremelanotide/) — “I tried it from two different sources. The only thing I got was nausea. I tried 1, 2 up to 4mg. No success. However, Im gonna try one more shot of Melanotan II.” (sha256 07a053f5be70ebf5)
31. [Has anyone tried pt 141 (bremelanotide)?](https://www.reddit.com/r/PSSD/comments/obx5ao/has_anyone_tried_pt_141_bremelanotide/) — “No. This does not work. It just makes you lightheaded.” (sha256 c7bbdeb2ec2d2c1c)
32. [Has anyone tried pt 141 (bremelanotide)?](https://www.reddit.com/r/PSSD/comments/obx5ao/has_anyone_tried_pt_141_bremelanotide/) — “It worked for me but gives a horrible headache” (sha256 60d0b3b0cd6b5688)
33. [Has anyone tried pt 141 (bremelanotide)?](https://www.reddit.com/r/PSSD/comments/obx5ao/has_anyone_tried_pt_141_bremelanotide/) — “It absolutely does nothing for me , viagra is much better than this” (sha256 7bb20f789699d7df)
34. [Has anyone tried pt 141 (bremelanotide)?](https://www.reddit.com/r/PSSD/comments/obx5ao/has_anyone_tried_pt_141_bremelanotide/) — “I actually went ahead and tried it with good results. So I can say it does help although it’s as needed and temporary” (sha256 8019bb45a6823362)
35. [PT-141](https://www.reddit.com/r/PSSD/comments/163vwxh/pt141/) — “This peptide is dangerous, MC4 stimulation can lead to anhedonia.” (sha256 5618aabb04a6f443)
36. [Oxytocin and bremelanotide? Should I try it](https://www.reddit.com/r/PSSD/comments/1r436jb/oxytocin_and_bremelanotide_should_i_try_it/) — “for some people actually pt-141 and oxytocin ( taken separately) helped in " short burst ", for other did nothing.” (sha256 054462d4884c0400)
37. [Oxytocin and bremelanotide? Should I try it](https://www.reddit.com/r/PSSD/comments/1r436jb/oxytocin_and_bremelanotide_should_i_try_it/) — “I think PT-141 (bremelanotide) is quite dangerous, years back in 2018 it sent me into a severe anhedonia episode at 200 mcg. Had to get ECT. I had symptoms basically resembling that of PSSD/PFS just from using it once.” (sha256 2cccad0364894293)
38. [my review of pt-141](https://x.com/LexiaLynx/status/2069799286867460226) — “my review of pt-141 it made me hard.. I guess, it did make me feel sick but not unbearable sickness.. Erections was easier to get but I'd prefer just taking viagra, I wouldn't do it again x it didn't make me any more or less horny, but erections came on easier x” (sha256 2af02d3dbddf9e91)
39. [PT-141 Experience - it absolutely works](https://www.reddit.com/r/erectiledysfunction/comments/1qik4vm/pt141_experience_it_absolutely_works/) — “It really felt like that old movie called awakenings... Well that has been my dick in the past 24 hours... So for me, I can understand how such an effective (300x at least better than Viagra or Cialis) medication is not popular at all. Such a shame really because it legitimately takes you back to being better than your 18 year old self... If I can eliminate the nausea then I will use this stuff at least once a week as a treat for me but if it causes the same level of nausea t” (sha256 d26a4ff39595142d)
40. [PT-141 the libido peptide?](https://www.reddit.com/r/NTNPerformance/comments/1sumfw4/pt141_the_libido_peptide/) — “I took 2 units and 1.5 hours later I had a raging boner! It would come and go for like 15 hours but was absolutely rock solid... The next time I took .75 and it was too low but I was able to have a good session with the wife... the next day I am pretty drained of energy.” (sha256 28211af964fb1154)
41. [PT-141 the libido peptide?](https://www.reddit.com/r/NTNPerformance/comments/1sumfw4/pt141_the_libido_peptide/) — “I’m a female (46), it makes me juicy and gets me ready to go. I don’t have low drive to begin with, but it certainly turns it up a notch. I take 2mg every now and then. No side effects for me. Only upside. Hubs takes it and has had some improvement sometimes. A few times it’s been incredible and a few times didn’t seem to do much.” (sha256 7aabdaee09db89eb)
42. [PT-141 the libido peptide?](https://www.reddit.com/r/NTNPerformance/comments/1sumfw4/pt141_the_libido_peptide/) — “Totally works for a boner; libido, not so much.” (sha256 c8fd8a1df813c939)
43. [PT-141 the libido peptide?](https://www.reddit.com/r/NTNPerformance/comments/1sumfw4/pt141_the_libido_peptide/) — “I have taken PT141 through a shot twice. First at .5mg and I didn’t really notice much. So the next time, I went up to 1mg and boy did I get nauseous for the entire afternoon and evening. But I was still able to perform later that night and then was erect on and off all night long.” (sha256 72b22b60e0d73154)
44. [antidepressant medications cause changes and suppression in DNA](https://www.reddit.com/r/PSSD/comments/1dghl81/antidepressant_medications_cause_changes_and/) — “I now include PT 141 (bremelanotide) injection 2 hour before sex (really helps me) I’m about 25% back to normal for my age. Yeah pssd can apparently be a life sentence” (sha256 78b8434cf198bb3f)
45. [I'm a doctor who treats both PFS and PSSD. I'm trying to figure out a compromise when patients with PFS are looking to take an SSRI to boost allopregnanolone levels, but I worry about PSSD and further complications. I'm wondering if those here with PSSD have particular opinions on "better" options.](https://www.reddit.com/r/PSSD/comments/1nfcmy2/im_a_doctor_who_treats_both_pfs_and_pssd_im/) — “PT-141 ( bremelanotide ), - oxytocin, - lamotrigine + psychostimulant such as Adderall, - lithium orotate (10-20 mg) + other molecules. - TRT (combo could ...” (sha256 ea87ec781ca72f03)
46. [PT-141 for libido?](https://www.reddit.com/r/PSSD/comments/14m9lmc/pt141_for_libido/) — “Is low libido your only symptom of PSSD ? How long have you been on TRT? Theres probably room for optimization of TRT. Are you on HCG for example ...” (sha256 2e35c8ea227729d6)
47. [Men with sexual dysfunction, how do cope?](https://www.reddit.com/r/PSSD/comments/1lnkjuc/men_with_sexual_dysfunction_how_do_cope/) — “PSSD has deleted my libido. I struggle in bed as a result. Humiliating and devastating. (I'm grateful to say that I don't have emotional/mental anhedonia ...” (sha256 a37748675595c043)
48. [In which way does pt141 increase libido? Do you think ...](https://www.reddit.com/r/Peptides/comments/tt2snq/in_which_way_does_pt141_increase_libido_do_you/) — “All people in the r/ pssd community suffer from permanent sexual dysfunction after using ssri medication and until now, there was found no way to ...” (sha256 551dbd6630a8271a)
49. [PT-141 (bremelanotide): the sexual health peptide that isn't a Viagra clone](https://www.reddit.com/r/NTNPerformance/comments/1tyketx/pt141_bremelanotide_the_sexual_health_peptide/) — “I’ve used it 2x so far. First dose was taken 45 minutes before. Felt no major difference but that morning I woke with major libido. Second time was that morning at 6am. By 10 pm I was ready to 🔥” (sha256 462c1316f94fb942)
50. [PT-141 (bremelanotide): the sexual health peptide that isn't a Viagra clone](https://www.reddit.com/r/NTNPerformance/comments/1tyketx/pt141_bremelanotide_the_sexual_health_peptide/) — “It gives me non-stop erections for hours! I mean no stimulation required.” (sha256 74d2ea787544a0b8)
51. [PT-141 (bremelanotide): the sexual health peptide that isn't a Viagra clone](https://www.reddit.com/r/NTNPerformance/comments/1tyketx/pt141_bremelanotide_the_sexual_health_peptide/) — “I got the worse side effects on it” (sha256 c09cc14e3c95b8ff)
52. [PT-141 for SSRI-induced dysfunction](https://x.com/eNavvi/status/1999856950025060808) — “PT-141 ≠ PDE5 inhibitors 🧠 A melanocortin receptor agonist that works centrally: • Activates CNS desire pathways • Treats libido, not just performance • Effective in both men & women • Helpful for SSRI-induced dysfunction” (sha256 512a57481d8b6014)
53. [Bremelanotide for PSSD](https://x.com/peptidewebmd/status/1974722035314995344) — “PSSD is a tough issue from SSRIs... Peptides such as Bremelanotide have shown promise in restoring sexual function.” (sha256 877c43c019d6ad8d)
54. [Vyleesi on SSRIs](https://x.com/_letterbxmb/status/1799098114789577119) — “This is a very weird Twitter question lol but to all my peeps on SSRI’s — have any of you tried those oils that make you more sensitive, sexually? I’m tired of feeling like a robot so I’m looking into that and possibly getting on Vyleesi cos I can’t just dump my meds” (sha256 deac8b30df0f1ea5)
55. [Pt-141 for PSSD](https://www.reddit.com/r/PSSD/comments/johaer/pt141_for_pssd/) — “its very very effective, way more so than cialis or viagra by a long shot, and increases sex drive way more. around 1-2mg is an effective dose. the other dude who said it didnt work might have had a shit supplier or did not dose high enough. it gives me raging boners that will not go down..” (sha256 eb2ea92b61135f91)
56. [Pt-141 for PSSD](https://www.reddit.com/r/PSSD/comments/johaer/pt141_for_pssd/) — “Gave me a hard erection the first time no libido” (sha256 973e3415a80e3096)
57. [Does anyone have personal experience with Vyleesi or Addyi?](https://www.reddit.com/r/DeadBedrooms/comments/ova4de/does_anyone_have_personal_experience_with_vyleesi/) — “I only took Vyleesi once... After about an hour and a half I had horrible restless legs... The combination of restless legs and increased sensitivity was a nightmare... the sex felt AMAZING... but if you have ever experienced restless legs than you know that the trade off for great sex is not worth it by any means.” (sha256 e807d4ec9547dec4)
58. [Does anyone have personal experience with Vyleesi or Addyi?](https://www.reddit.com/r/DeadBedrooms/comments/ova4de/does_anyone_have_personal_experience_with_vyleesi/) — “I did addyi for about 7 weeks. I would not recommend it. I had so much dizziness and lightheadedness. I had no energy or drive to do anything, least of all have sex. The worst were the heart flutters I had.” (sha256 4af0ca17455da8f4)
59. [X post on PT-141](https://x.com/ouranometrian2/status/2057535973458575731) — “Pt 141. It was originally for female sexual dysfunction. It works well. Also some women found once they stop taking it there is a lasting effect. You know, sexuality being.more than just physiological.” (sha256 7512cbde3170ff7d)
60. [X post on PT-141](https://x.com/MonicaMAlmaguer/status/2046265961766916117) — “Wife can't or won't try HRT? PT-141 (also prescribed as Vyleesi) is a peptide that increases sex drive and treats sexual dysfunction in both men and women by activating melanocortin receptors in the brain. Combined with localized vaginal estrodial (does not enter blood stream), this can be a winning combo!” (sha256 a766e45298759aa0)