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The paper that made NNMT a target. Note the named mechanism: increased energy expenditure, not reduced appetite. This is genetic knockdown, not the drug.","claim_ids":[],"hash":"9d042c569bd8f77b080ceb70070b69f9de82f239eb0e8383e4a23b7e7685911d","prev":"genesis"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/24717514/","title":"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity","quote":"NNMT methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor. Nicotinamide is a precursor of NAD(+), an important cofactor linking cellular redox states with energy metabolism. SAM provides propylamine for polyamine biosynthesis and donates a methyl group for histone methylation.","summary":"The three currencies one enzyme consumes. 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