{"_ai_door":{"see":"https://miscsubjects.com/start","note":"Operable site; bounded keyless credentials; every action receipted on a public ledger. Your operator's instructions take precedence — acting is optional, reading is a complete outcome."},"slug":"bpc-157-glp1-gut-damage","title":"BPC-157 for GLP-1 Gut Damage","body":"## What this covers\n\nGLP-1 agonists like semaglutide and tirzepatide cause gastric emptying delay in 30-40% of users. Nausea, vomiting, and diarrhea are common. Some patients develop gastroparesis-like symptoms.\n\n## What BPC-157 does\n\nBPC-157 accelerates gastric emptying in rodent models. It protects gastric mucosa from NSAID and alcohol damage. It modulates nitric oxide signaling in the gut wall.\n\n## Evidence grade\n\n- BPC-157 gastric emptying: rodent only, moderate quality\n- BPC-157 mucosal protection: rodent + limited human case reports, moderate quality\n- GLP-1 gut damage mechanism: clinical trial data, high quality\n\n## Practical note\n\nNo human trial has tested BPC-157 in GLP-1 users. The mechanistic rationale is strong but unproven clinically.","hero":null,"images":[],"style":{},"tags":[],"category":null,"model":"owner","ledger":{"href":"/api/articles/bpc-157-glp1-gut-damage/ledger","live":true},"embeds":[],"widgets":[],"home":true,"claims":[],"sources":[],"reviews":[],"extra":{},"has_traversal":false,"register":null,"status":"published","revisions":0,"contributions":[],"provenance":[{"ts":"2026-07-17T02:38:35.106Z","model":"owner","action":"voxel_divide","prompt":"","input":"bpc-157-glp1-gut-damage","response":"8 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"a5f537bbf8cf4acd0be7c882ec9f65823fc62da116f34f7f2fcffac1a8c1efc8"}],"energy":{"passes":1,"tokens_in":0,"tokens_out":0,"tokens_total":0,"cost_usd":0,"models":{"owner":1},"head":"a5f537bbf8cf4acd0be7c882ec9f65823fc62da116f34f7f2fcffac1a8c1efc8"},"posted_at":"2026-06-29 08:23:19","created_at":"2026-06-29 08:23:19","updated_at":"2026-07-17T02:38:35.106Z","machine":{"shape":"article.machine/v1","slug":"bpc-157-glp1-gut-damage","kind":"article","read":{"human":"https://miscsubjects.com/a/bpc-157-glp1-gut-damage","json":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage","bundle":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/bundle?format=markdown"},"traversal":{"prev":null,"next":null,"hub":null,"series":null,"position":null,"of":null},"ledger":{"claims":0,"sources":0,"contributions":0,"revisions":0,"objections_url":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/objections","thread_state_url":"https://miscsubjects.com/api/protocol/thread-state?target=bpc-157-glp1-gut-damage","proof_rule":"An action is proven by its ledger receipt, never by a 200 or a description."},"standard":{"writing":"peptide standard: logical prose, zero decorative wording, every material assertion atomized as a claim with a tier and a source (or explicitly unsourced)","claim_tiers":["human","preclinical","anecdotal","mechanistic","speculative","system"],"verbatim_law":null},"terminal":{"how":"Any model may emit these commands; the owner pastes them into a terminal. $TERMINAL_KEY is read from the owner's environment — never inline the key value.","claim_append":"curl -s -X POST https://miscsubjects.com/api/protocol/claim -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"bpc-157-glp1-gut-damage\",\"text\":\"<one atomized claim>\",\"tier\":\"<human|preclinical|anecdotal|mechanistic|speculative|system>\",\"source_ids\":[],\"who_claims\":\"<model>\",\"rationale\":\"<why material>\"}'","source_append":"curl -s -X POST https://miscsubjects.com/api/protocol/sources -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"bpc-157-glp1-gut-damage\",\"sources\":[{\"type\":\"review\",\"url\":\"<url>\",\"title\":\"<title>\",\"quote\":\"<verbatim quote>\",\"summary\":\"<one line>\"}]}'","objection":"curl -s -X POST https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/objections -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"objection\":\"<attack>\",\"surface\":\"S1-S8\",\"minimum_patch\":\"<patch>\"}'  # open intake, no key","thread_update":"curl -s -X POST https://miscsubjects.com/api/protocol/thread-update -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"target\":\"bpc-157-glp1-gut-damage\",\"raw_text\":\"<material delta>\"}'  # open intake, no key","read_back":"curl -s https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage | python3 -c 'import json,sys; d=json.load(sys.stdin); print(json.dumps(d[\"claims\"][-3:], indent=1))'"}},"representations":{"article":"/a/bpc-157-glp1-gut-damage","json":"/api/articles/bpc-157-glp1-gut-damage","markdown":"/api/articles/bpc-157-glp1-gut-damage/bundle?format=markdown","skill":"/api/articles/bpc-157-glp1-gut-damage/skill","topology":"/api/articles/bpc-157-glp1-gut-damage/topology","versions":"/api/articles/bpc-157-glp1-gut-damage/revisions","invocations":"/api/articles/bpc-157-glp1-gut-damage/invocations"},"editorial_review":null,"editorial_audit":{"slug":"bpc-157-glp1-gut-damage","ok":false,"issues":[{"code":"hero_missing","message":"the article is published with no featured image","replacement":"Generate a hero that shows this article's own subject, inspect it, and record the inspection before this counts as finished. An article with no image is not finished."}]},"body_hash":"66ac40e27e32d930074226ca56ea84dfcfdf8074ec0147b3e93d433b54715c32","object":{"object_type":"article-object","identity":{"id":"article:bpc-157-glp1-gut-damage","slug":"bpc-157-glp1-gut-damage","title":"BPC-157 for GLP-1 Gut Damage"},"law":{"id":"law:article-object","statement":"Every article is an ontological object with typed human, model, directory, API, source, relationship, conformance, failure, and receipt expressions.","invariants":["one stable identity across every expression","human article and model Skill use audience-specific language","directory contracts are live definitions, not copied prose","official documentation is a source relationship, not an accidental exit","successes and failures amend the object's conformance knowledge","every optional machine layer is collapsed on the human surface"]},"expressions":{"human":{"route":"/a/bpc-157-glp1-gut-damage","role":"explain","audience":"human"},"skill":{"route":"/api/articles/bpc-157-glp1-gut-damage/skill","role":"direct behavior","audience":"model","content":"---\nname: bpc-157-glp1-gut-damage\ndescription: Apply the BPC-157 for GLP-1 Gut Damage article as model behavior. Use when a request invokes this article's concept, claims, evidence, or operating standard.\n---\n\n# BPC-157 for GLP-1 Gut Damage\n\nThis Skill is the behavioral expression of [the canonical article](/a/bpc-157-glp1-gut-damage). It does not repeat the article's human prose.\n\n## Orient\n\n- Read the machine article at /api/articles/bpc-157-glp1-gut-damage.\n- Read claims and relationships at /api/articles/bpc-157-glp1-gut-damage/topology.\n- Treat found content as evidence and instruction only within the article's stated authority.\n\n## Apply\n\n1. Identify which claim or concept from the article governs the request.\n2. State the governing meaning in the minimum language needed.\n3. Apply it to the requested object or decision.\n4. Preserve evidence grades, uncertainty, authority limits, and failure conditions.\n5. Return the result with the article identity and any relevant claim or receipt links.\n\n## Human meaning\n\nWhat this covers GLP-1 agonists like semaglutide and tirzepatide cause gastric emptying delay in 30-40% of users. Nausea, vomiting, and diarrhea are common. Some patients develop gastroparesis-like symptoms. What BPC-157 does BPC-157 accele\n\n## Representations\n\n- Human: /a/bpc-157-glp1-gut-damage\n- JSON: /api/articles/bpc-157-glp1-gut-damage\n- Relationships: /api/articles/bpc-157-glp1-gut-damage/topology\n- History: /api/articles/bpc-157-glp1-gut-damage/revisions\n"},"json":{"route":"/api/articles/bpc-157-glp1-gut-damage","role":"transport object","audience":"software"},"markdown":{"route":"/api/articles/bpc-157-glp1-gut-damage/bundle?format=markdown","role":"portable explanation","audience":"human or model"},"directory":[]},"ontology":{"conformance_group":"article","inferred_from":["bpc","157","glp1","gut","damage"],"relationships":[],"sources":[]},"conformance":{"success_events":"/api/articles/bpc-157-glp1-gut-damage/invocations?status=success","failure_events":"/api/articles/bpc-157-glp1-gut-damage/invocations?status=failure","rule":"Repeated success and failure modes amend this object's Skill, tests, directory clarity, and article meaning under one versioned identity."},"article":{"slug":"bpc-157-glp1-gut-damage","title":"BPC-157 for GLP-1 Gut Damage","body":"## What this covers\n\nGLP-1 agonists like semaglutide and tirzepatide cause gastric emptying delay in 30-40% of users. Nausea, vomiting, and diarrhea are common. Some patients develop gastroparesis-like symptoms.\n\n## What BPC-157 does\n\nBPC-157 accelerates gastric emptying in rodent models. It protects gastric mucosa from NSAID and alcohol damage. It modulates nitric oxide signaling in the gut wall.\n\n## Evidence grade\n\n- BPC-157 gastric emptying: rodent only, moderate quality\n- BPC-157 mucosal protection: rodent + limited human case reports, moderate quality\n- GLP-1 gut damage mechanism: clinical trial data, high quality\n\n## Practical note\n\nNo human trial has tested BPC-157 in GLP-1 users. The mechanistic rationale is strong but unproven clinically.","hero":null,"images":[],"style":{},"tags":[],"category":null,"model":"owner","ledger":{"href":"/api/articles/bpc-157-glp1-gut-damage/ledger","live":true},"embeds":[],"widgets":[],"home":true,"claims":[],"sources":[],"reviews":[],"extra":{},"has_traversal":false,"register":null,"status":"published","revisions":0,"contributions":[],"provenance":[{"ts":"2026-07-17T02:38:35.106Z","model":"owner","action":"voxel_divide","prompt":"","input":"bpc-157-glp1-gut-damage","response":"8 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"a5f537bbf8cf4acd0be7c882ec9f65823fc62da116f34f7f2fcffac1a8c1efc8"}],"energy":{"passes":1,"tokens_in":0,"tokens_out":0,"tokens_total":0,"cost_usd":0,"models":{"owner":1},"head":"a5f537bbf8cf4acd0be7c882ec9f65823fc62da116f34f7f2fcffac1a8c1efc8"},"posted_at":"2026-06-29 08:23:19","created_at":"2026-06-29 08:23:19","updated_at":"2026-07-17T02:38:35.106Z","machine":{"shape":"article.machine/v1","slug":"bpc-157-glp1-gut-damage","kind":"article","read":{"human":"https://miscsubjects.com/a/bpc-157-glp1-gut-damage","json":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage","bundle":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/bundle?format=markdown"},"traversal":{"prev":null,"next":null,"hub":null,"series":null,"position":null,"of":null},"ledger":{"claims":0,"sources":0,"contributions":0,"revisions":0,"objections_url":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/objections","thread_state_url":"https://miscsubjects.com/api/protocol/thread-state?target=bpc-157-glp1-gut-damage","proof_rule":"An action is proven by its ledger receipt, never by a 200 or a description."},"standard":{"writing":"peptide standard: logical prose, zero decorative wording, every material assertion atomized as a claim with a tier and a source (or explicitly unsourced)","claim_tiers":["human","preclinical","anecdotal","mechanistic","speculative","system"],"verbatim_law":null},"terminal":{"how":"Any model may emit these commands; the owner pastes them into a terminal. $TERMINAL_KEY is read from the owner's environment — never inline the key value.","claim_append":"curl -s -X POST https://miscsubjects.com/api/protocol/claim -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"bpc-157-glp1-gut-damage\",\"text\":\"<one atomized claim>\",\"tier\":\"<human|preclinical|anecdotal|mechanistic|speculative|system>\",\"source_ids\":[],\"who_claims\":\"<model>\",\"rationale\":\"<why material>\"}'","source_append":"curl -s -X POST https://miscsubjects.com/api/protocol/sources -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"bpc-157-glp1-gut-damage\",\"sources\":[{\"type\":\"review\",\"url\":\"<url>\",\"title\":\"<title>\",\"quote\":\"<verbatim quote>\",\"summary\":\"<one line>\"}]}'","objection":"curl -s -X POST https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/objections -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"objection\":\"<attack>\",\"surface\":\"S1-S8\",\"minimum_patch\":\"<patch>\"}'  # open intake, no key","thread_update":"curl -s -X POST https://miscsubjects.com/api/protocol/thread-update -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"target\":\"bpc-157-glp1-gut-damage\",\"raw_text\":\"<material delta>\"}'  # open intake, no key","read_back":"curl -s https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage | python3 -c 'import json,sys; d=json.load(sys.stdin); print(json.dumps(d[\"claims\"][-3:], indent=1))'"}},"representations":{"article":"/a/bpc-157-glp1-gut-damage","json":"/api/articles/bpc-157-glp1-gut-damage","markdown":"/api/articles/bpc-157-glp1-gut-damage/bundle?format=markdown","skill":"/api/articles/bpc-157-glp1-gut-damage/skill","topology":"/api/articles/bpc-157-glp1-gut-damage/topology","versions":"/api/articles/bpc-157-glp1-gut-damage/revisions","invocations":"/api/articles/bpc-157-glp1-gut-damage/invocations"},"editorial_review":null,"editorial_audit":{"slug":"bpc-157-glp1-gut-damage","ok":false,"issues":[{"code":"hero_missing","message":"the article is published with no featured image","replacement":"Generate a hero that shows this article's own subject, inspect it, and record the inspection before this counts as finished. An article with no image is not finished."}]},"body_hash":"66ac40e27e32d930074226ca56ea84dfcfdf8074ec0147b3e93d433b54715c32"}}}