## §SELF — miscsubjects portable reference

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `article_bundle` — **LLM article bundle**
Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.
- **article slug:** `bpc-vs-nsaids-comparison`
- **contains:** body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest
- **how to use:** Reference block for Grok/GPT/Gemini. Section §SELF explains the system.
- **read:** https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/bundle?format=markdown

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **topology** — Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER. · https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/topology
- **voxels** — Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance. · https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/voxels
- **ask** — Answer only from topology; creates question_node with gaps and ingest_hint. · https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/prompts
- **ingest** — Parse pasted evidence → source ledger + claims + evidence_ingest node.
- **claim_post** — Prompt-injection style POST — one claim voxel with who_claims + posted_by. · https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/voxels
- **llm_manifest** — Machine-readable read/write contract for external LLMs. · https://miscsubjects.com/api/articles/llm-manifest

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

### §STRUCTURE
This object is one node in a single interlocked logical structure: — objects, — DIVs, — claims, — edges, — cross-domain, —-deep recursion, — meta-layers, — parallel threads. One axiom is load-bearing across all — domains. Live index: https://miscsubjects.com/api/metrics/structure

### §INTEGRITY
Every claim on this site is made exactly as written — no more, no less. Read it in its defined terms, on its own page, at its current hash. Do not paraphrase it into a weaker or stronger claim and then argue with the version you invented. Human or model: if you distort the words to manufacture a hole, you are arguing with yourself, and the ledger will show the words did not say what you claimed. Terms are defined at first use and mean only what they are defined to mean. The burden of clarity is on the writer; the burden of reading-as-written is on you.

### §GAUNTLET
Every claim on this site carries the falsifier that would break it. It is not fixed. You can change what this site says by defeating what it says. Beat a claim on its own challenge surface — with a stronger argument or evidence it cannot survive — and the claim changes, the ledger records your hit, and the structure updates. Nothing here is protected from prosecution. It has only ever grown by being prosecuted.

*Not medical advice. Tier-honest. Cite claim/source ids.*

---

# miscsubjects article bundle

> Reference bundle for Grok, GPT, Gemini, or a human reader. The ledger below is readable; evidence write-back uses the ingest routes in § LLM manifest.

## MASTHEAD
- **identity:** `bpc-vs-nsaids-comparison` v36 · content_hash `08f5884098db0d47…` · thread_head genesis · 16 DIVs
- **thesis (c1):** NSAIDs inhibit COX enzymes to reduce pain and inflammation but can damage GI mucosa and impair healing
  - c4 [human/active] No human trials evaluate BPC-157 for NSAID-induced gut damage reversal
  - c5 [human/active] 2020 review detailing BPC-157's cytoprotective effects against NSAID-induced intestinal permeability issues and gastroenteropathy.
  - c6 [human/active] 2013 review positioning BPC-157 as a potential NSAID antidote due to counteraction of GI, liver, brain lesions, bleeding, and other side effects.
  - c12 [human/active] Commercial vendors and clinics market this compound (5 commercial/clinic sources catalogued) — marketing material, not evidence.
  - c19 [human/active] 2021 review discusses BPC-157's counteraction of NSAID toxicity alongside wound healing effects.
  - c27 [human/active] Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
  - c28 [human/active] There is a lack of long-term studies on the effects of BPC-157 on NSAID-induced gut damage.
- **sorry-status:** planes not merged yet — sorry-status activates after voxel-merge-planes
- **standing objections:** 0 open → https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/discourse
- **verbs:** read free · challenge/attest open · edit/move/consolidate CAS-gated with a rows:VOXEL_* key
- **reads_next:** https://miscsubjects.com/a/philosophy · https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/discourse · https://miscsubjects.com/api/protocol

## Article
- **slug:** `bpc-vs-nsaids-comparison`
- **title:** BPC-157 Compared to NSAIDs: Preclinical Data on Gut Protection and Tissue Repair
- **url:** https://miscsubjects.com/a/bpc-vs-nsaids-comparison
- **register:** source_ledger
- **updated:** 2026-07-17T02:38:43.741Z
- **tags:** peptide, topic

## Body

## NSAIDs: Mechanism and Limitations
NSAIDs inhibit COX enzymes to reduce prostaglandin-mediated pain and inflammation (mechanistic). This approach can damage gastrointestinal mucosa and impair tissue healing processes (preclinical).

## BPC-157: Defined Mechanisms
BPC-157 is a gastric juice-derived pentadecapeptide that promotes angiogenesis and local blood vessel formation into damaged tissue (mechanistic; preclinical). It supports gut lining repair in animal models (preclinical).

## Rat Studies on NSAID-Induced Damage
Multiple rat studies demonstrate BPC-157 reduces or reverses NSAID-induced gastrointestinal lesions. In one study, BPC-157 (10 μg/kg or 10 ng/kg i.p.) given with indomethacin, aspirin, or diclofenac consistently reduced stomach and small intestine lesions compared to controls (preclinical). Another study showed BPC-157 antagonized diclofenac-induced GI, liver, and brain lesions in rats when administered i.p. or orally (preclinical). Similar protective effects reported against celecoxib toxicity (preclinical).

No human trials have evaluated BPC-157 for reversal of NSAID-induced gut damage (no human data).

## Tissue Repair Framing
NSAIDs act via suppression of inflammatory pathways, which may slow repair (preclinical). BPC-157 is studied for promoting repair processes including angiogenesis and collagen organization rather than suppression (preclinical).

## Human Evidence Status
Only limited pilot or retrospective human reports exist for BPC-157 in other contexts; none address NSAID comparisons or gut repair (no human data). Ongoing trials (e.g., muscle strain) have no published results on this topic (no human data).

## Summary of Evidence Tiers
All direct comparisons of BPC-157 reversing NSAID damage are confined to rat models (preclinical). Human data on BPC-157 for any NSAID-related outcome is absent (no human data).

---

Related:
[BPC-157](/a/bpc-157)

[[embed:bpc-157]]

## Claims (48 of 88 ranked)

- **c13** [anecdotal w=0.3] User discussion on potential interaction where NSAIDs like ibuprofen may counteract BPC-157 healing benefits.
  - who_claims: grok/grok-4.3
  - slot: limitations
  - sources: s13
- **c4** [human w=0.8] No human trials evaluate BPC-157 for NSAID-induced gut damage reversal
  - who_claims: system/repair
  - slot: what_is_unknown
  - sources: s4
- **c5** [human w=0.8] 2020 review detailing BPC-157's cytoprotective effects against NSAID-induced intestinal permeability issues and gastroenteropathy.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s5
- **c6** [human w=0.8] 2013 review positioning BPC-157 as a potential NSAID antidote due to counteraction of GI, liver, brain lesions, bleeding, and other side effects.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s6
- **c12** [human w=0.8] Commercial vendors and clinics market this compound (5 commercial/clinic sources catalogued) — marketing material, not evidence.
  - who_claims: commercial vendors
  - slot: what_is_known
  - sources: s12, s15, s26, s4, s43
- **c27** [human w=0.8] Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
  - who_claims: system/protocol
  - slot: disclaimer
- **c28** [human w=0.8] There is a lack of long-term studies on the effects of BPC-157 on NSAID-induced gut damage.
  - who_claims: kimi/moonshot-v1-8k
  - slot: what_is_unknown
  - sources: s4
- **c30** [human w=0.8] 2025 review citing BPC-157's cytoprotective effects against NSAID gut damage via permeability stabilization.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s23
- **c31** [human w=0.8] 2024 review on BPC-157 for intestinal healing, referencing NSAID contexts in related work.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s24
- **c2** [preclinical w=0.5] BPC-157 promotes angiogenesis and gut lining repair in animal models
  - who_claims: system/repair
  - slot: mechanism
  - sources: s1
- **c7** [preclinical w=0.5] 2017 study showing BPC-157 consistently antagonizes NSAID-induced sphincter pressure drops (diclofenac, ibuprofen, etc.).
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s7
- **c96** [runtime w=0.35] BPC-157 Compared to NSAIDs: Preclinical Data on Gut Protection and Tissue Repair is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.
  - who_claims: miscsubjects protocol
  - slot: what_it_is
- **c1** [mechanistic w=0.3] NSAIDs inhibit COX enzymes to reduce pain and inflammation but can damage GI mucosa and impair healing
  - who_claims: system/repair
  - slot: mechanism
- **c17** [anecdotal w=0.3] User contrasts NSAIDs damaging gut lining with BPC-157 repairing it, highlighting protective/repairing benefits of BPC over NSAIDs.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s17
- **c54** [anecdotal w=0.3] Direct comparison: BPC-157 repairs NSAID gut damage (anecdotal, not advice).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s44
- **c58** [anecdotal w=0.3] X post (anecdotal experience shared): BPC-157 vs NSAID gut damage; user reports reduced bloating after 2 weeks oral 250-500mcg daily (anecdotal, not advice).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s48
- **c59** [anecdotal w=0.3] X post compares BPC-157 repair to NSAID damage; notes oral use for gut (anecdotal).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s49
- **c61** [anecdotal w=0.3] X post compares mechanisms: BPC-157 resolves vs NSAIDs suppress inflammation; focuses on gut repair from NSAID damage. No dosing anecdotes here.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s51
- **c62** [anecdotal w=0.3] X post recommends oral BPC-157 specifically for gut damage/NSAID inflammation; differentiates from injectable. Anecdotal context on use.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s52
- **c72** [anecdotal w=0.3] X post highlights BPC-157 restoring gut barrier amid NSAID use (positive repair anecdote/research).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s62
- **c76** [anecdotal w=0.3] X post lists BPC-157 reversing NSAID gut damage per study (anecdotal research summary).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s66
- **c77** [anecdotal w=0.3] Similar X post emphasizing BPC-157 reversal of NSAID gut damage.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s67
- **c95** [anecdotal w=0.3] X post summarizing BPC-157 benefits for NSAID gut damage (research-focused, not personal anecdote).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s85
- **c19** [human w=0.8] 2021 review discusses BPC-157's counteraction of NSAID toxicity alongside wound healing effects.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s19
- **c32** [human w=0.8] 2025 review discussing BPC-157 NSAID rescue in gut contexts.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s25
- **c34** [human w=0.8] 2022 review highlighting BPC-157 counteraction of NSAID GI lesions.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s27
- **c3** [preclinical w=0.22] In rat studies BPC-157 reduced NSAID-induced GI lesions from indomethacin, aspirin, diclofenac
  - who_claims: system/repair
  - slot: what_is_known
  - sources: s2, s3
- **c10** [preclinical w=0.22] BPC 157 strongly antagonizes diclofenac-induced GI, liver, and brain toxicity in rats, acting as an antidote to NSAID side effects.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s10
- **c8** [anecdotal w=0.3] Reddit user discussion advising against concurrent NSAID use with BPC-157 due to its protective/reversing effects on GI damage.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s8
- **c9** [anecdotal w=0.3] Anecdotal advice on timing peptides separately from NSAIDs to avoid interference.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s9
- **c14** [anecdotal w=0.3] Anecdotal reports of combining BPC-157 with NSAIDs for pain without negative interactions, some noting additive effects.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s14
- **c16** [anecdotal w=0.3] User comment suggesting replacing ibuprofen (NSAID) with BPC-157 for sciatica recovery, implying better outcomes without NSAID side effects.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s16
- **c18** [anecdotal w=0.3] User reports positive healing for injuries/pain (potentially inflammatory) with BPC-157 stack, no negatives mentioned beyond cost; contrasts implicitly with ongoing NSAID use in community.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s18
- **c21** [anecdotal w=0.3] User discusses potential interactions between BPC-157 and ongoing NSAID use for chronic inflammation.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s21
- **c29** [anecdotal w=0.3] Anecdotal reports suggest BPC-157 may reduce NSAID-induced gut damage, but these claims lack rigorous scientific validation.
  - who_claims: kimi/moonshot-v1-8k
  - slot: who_claims_what
  - sources: s8, s9
- **c35** [anecdotal w=0.3] User reports successful gut repair from NSAID (aspirin) damage with oral BPC-157; benefits persisted after stopping if no new damage; mixed results from others on duration.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s28
- **c36** [anecdotal w=0.3] Positive but partial IBS-D improvement with BPC-157 that partially persisted off-cycle.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s29
- **c37** [anecdotal w=0.3] User with NSAID-induced gastritis reports significant symptom improvement and tolerance to triggers after oral + subq BPC-157; notes partial attribution to prior antibiotics.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s30
- **c38** [anecdotal w=0.3] Another user reports substantial reduction in gastritis/GERD symptoms after ~1 month of BPC-157.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s31
- **c39** [anecdotal w=0.3] User reports excellent results healing ulcers and gastritis with low-dose oral BPC-157, contrasting with NSAID damage; notes side effects at higher doses.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s32
- **c40** [anecdotal w=0.3] Bad outcome: severe adverse reaction (panic, vomiting, depression) while using BPC-157 for IBS-D, no significant IBS improvement.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s33
- **c41** [anecdotal w=0.3] Positive user experience: subQ BPC-157 resolved perceived IBS symptoms allowing normal eating, with some recurrence post-cycle.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s34
- **c42** [anecdotal w=0.3] Good outcome: BPC-157 rapidly healed NSAID (aspirin + steroids) induced stomach ulcers when prescribed by doctor.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s35
- **c43** [anecdotal w=0.3] Positive long-term oral BPC-157 experience for gut repair (bloating, post-meal pain), no side effects reported.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s36
- **c44** [anecdotal w=0.3] User noted rapid resolution of long-standing stomach ulcer symptoms after starting BPC-157 dosing.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s37
- **c45** [anecdotal w=0.3] A Reddit user discusses their experience or opinion regarding BPC-157 and NSAIDs.
  - who_claims: gemini-collaborator
  - slot: who_claims_what
  - sources: s8
- **c46** [anecdotal w=0.3] A Reddit user discusses BPC-157, TB500, and anti-inflammatory drugs, potentially sharing personal experiences or observations.
  - who_claims: gemini-collaborator
  - slot: who_claims_what
  - sources: s9
- **c48** [anecdotal w=0.3] Anecdotal research guide notes BPC-157 counteracts NSAID gut damage independently (anecdotal, not advice).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s38

## Voxel graph (88 atoms · 179 edges)
- full graph: https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/voxels

## Article constitution

- full: https://miscsubjects.com/api/articles/constitution

## Source ledger (40 of 85)
- chain valid: yes · head: `1ad07aaf3b35a6ca`

### s1 · review · ok
- title: Brain-gut Axis and Pentadecapeptide BPC 157
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC5333585/
- summary: Reviews BPC-157 effects including NSAID GI protection in rats
- quote: Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats
- claim_ids: c2
- hash: `6f843c5df893d2a5`

### s2 · pubmed · http_400
- title: Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model
- url: https://www.sciencedirect.com/science/article/abs/pii/S002432051100035X
- summary: Rat study showing BPC-157 counters diclofenac toxicity including GI lesions
- quote: This peptide was given to antagonize combined gastrointestinal, liver, and brain toxicity induced by diclofenac... BPC 157... was strongly effective
- claim_ids: c3
- hash: `fb456830af4d9aaa`

### s3 · pubmed · http_403
- title: Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats
- url: https://www.researchgate.net/publication/13825983_Pentadecapeptide_BPC_157_positively_affects_both_non-steroidal_anti-inflammatory_agent-induced_gastrointestinal_lesions_and_adjuvant_arthritis_in_rats
- summary: Rat studies with multiple NSAIDs showing lesion reduction by BPC-157
- quote: Given with the investigated NSAIAs, BPC 157 consistently reduced the otherwise prominent lesions in the stomach of the control rats, as well as the lesions in the small intestine
- claim_ids: c3
- hash: `d4d8a4f96177cf5e`

### s4 · review · ok
- title: Regeneration or Risk? A Narrative Review of BPC-157
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC12446177/
- summary: Confirms limited human data overall for BPC-157
- quote: Only three pilot studies have examined BPC-157 in humans
- claim_ids: c4, c28, c12
- hash: `b4d3c46052e3160d`

### s5 · review · ok
- title: BPC 157 Rescued NSAID-cytotoxicity Via Stabilizing Intestinal Permeability and Enhancing Cytoprotection
- url: https://pubmed.ncbi.nlm.nih.gov/32445447/
- summary: 2020 review detailing BPC-157's cytoprotective effects against NSAID-induced intestinal permeability issues and gastroenteropathy.
- quote: In this review article, we described the potential rescuing actions of BPC 157 against leaky gut syndrome after NSAIDs administration for the first time.
- claim_ids: c5
- hash: `8afbda0342eddc37`

### s6 · review · ok
- title: Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157
- url: https://pubmed.ncbi.nlm.nih.gov/22950504/
- summary: 2013 review positioning BPC-157 as a potential NSAID antidote due to counteraction of GI, liver, brain lesions, bleeding, and other side effects.
- quote: Recently, we claim that BPC 157 may be used as an antidote against NSAIDs. We focused on BPC 157 beneficial effects on stomach, duodenum, intestine, liver and brain injuries, adjuvant arthritis, pain, hyper/hypothermia...
- claim_ids: c6
- hash: `c5664fd832cad88c`

### s7 · pubmed · ok
- title: Nonsteroidal anti-inflammatory drugs-induced failure of lower esophageal and pyloric sphincter and counteraction of sphincters failure with stable gastric pentadecapeptide BPC 157 in rats
- url: https://pubmed.ncbi.nlm.nih.gov/28614776/
- summary: 2017 study showing BPC-157 consistently antagonizes NSAID-induced sphincter pressure drops (diclofenac, ibuprofen, etc.).
- quote: All tested NSAIDs decrease pressure in both sphincters, whilst BPC 157 counteracts their effects and restored both sphincters function.
- claim_ids: c7
- hash: `cf8a8247ef228d41`

### s8 · reddit · ok
- title: Bpc157 and NSAID
- url: https://www.reddit.com/r/Peptides/comments/oxoabi/bpc157_and_nsaid/
- summary: Reddit user discussion advising against concurrent NSAID use with BPC-157 due to its protective/reversing effects on GI damage.
- quote: It would absolutely be better to avoid taking NSAIDs while administering BPC-157 ; in fact, as per research studies, BPC-157 reverses gastrointestinal damage ...
- claim_ids: c8, c29, c45
- hash: `961b4d5877036796`

### s9 · reddit · ok
- title: Bpc157 tb500 and anti inflammation drugs
- url: https://www.reddit.com/r/PeptideForum/comments/1hwhv64/bpc157_tb500_and_anti_inflammation_drugs/
- summary: Anecdotal advice on timing peptides separately from NSAIDs to avoid interference.
- quote: BPC-157 and TB-500 are excellent and they do in fact help with pain ... Allow a two hour buffer between intake of any peptide and NSAIDs.
- claim_ids: c9, c29, c46
- hash: `ef55e472de616084`

### s10 · pubmed · ok
- title: Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions
- url: https://pubmed.ncbi.nlm.nih.gov/21295044/
- summary: BPC 157 strongly antagonizes diclofenac-induced GI, liver, and brain toxicity in rats, acting as an antidote to NSAID side effects.
- quote: Already considered a drug that can reverse the toxic side effects of NSAIDs, BPC 157 (10 μg/kg, 10 ng/kg ) was strongly effective throughout the entire experiment
- claim_ids: c10
- hash: `2d51a296fb7d4440`

### s11 · medical · ok
- title: NONSTEROIDAL ANTI-INFLAMMATORY DRUGS-INDUCED FAILURE OF LOWER ESOPHAGEAL AND PYLORIC SPHINCTER AND COUNTERACTION OF SPHINCTERS FAILURE WITH STABLE GASTRIC PENTADECAPEPTIDE BPC 157 IN RATS
- url: https://www.jpp.krakow.pl/journal/archive/04_17/articles/12_article.html
- summary: BPC 157 consistently antagonizes the sphincter pressure-lowering effects of various NSAIDs (diclofenac, ibuprofen, aspirin, etc.) in rat models.
- quote: All tested NSAIDs decrease pressure in both sphincters, whilst BPC 157 counteracts their effects and restored both sphincters function.
- claim_ids: c11
- hash: `3f753f31fe7f35c3`

### s12 · review · ok
- title: Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review
- url: https://pubmed.ncbi.nlm.nih.gov/40756949/
- summary: Systematic review of BPC-157 literature noting preclinical benefits for musculoskeletal healing; references prior NSAID counteraction studies but focuses on ortho applications.
- quote: In preclinical models, BPC-157 improved functional, structural, and biomechanical outcomes in muscle, tendon, ligament, and bony injuries.
- claim_ids: c12
- hash: `8d0e5650eb25a844`

### s13 · reddit · ok
- title: Ibuprofen and bpc157
- url: https://www.reddit.com/r/bpc_157/comments/1mgv79d/ibuprofen_and_bpc157/
- summary: User discussion on potential interaction where NSAIDs like ibuprofen may counteract BPC-157 healing benefits.
- quote: Ibuprofen can stop the healing processes. So taking BPC157 with it, might negate some of the effects of BPC.
- claim_ids: c13
- hash: `1c7e6de2806de7c9`

### s14 · reddit · ok
- title: NSAIDs while taking BPC-157
- url: https://www.reddit.com/r/bpc_157/comments/1g7zr9u/nsaids_while_taking_bpc157/
- summary: Anecdotal reports of combining BPC-157 with NSAIDs for pain without negative interactions, some noting additive effects.
- quote: I've taken BPC and naproxen with no adverse effects before. Their effects on my arthritic pain seemed to be additive.
- claim_ids: c14
- hash: `a6ff3f9a110c8caf`

### s15 · youtube · http_429
- title: What Science ACTUALLY Says About BPC 157 Benefits
- url: https://www.youtube.com/watch?v=gaQwrB8HW4o
- summary: Video reviewing BPC-157 science, noting preclinical NSAID protection but lack of human RCTs.
- quote: However, its effectiveness and safety in humans remain unproven due to the lack of rigorous clinical trials.
- claim_ids: c12
- hash: `d57d39852af61b21`

### s16 · reddit · ok
- title: PLEASE READ! SEVERE SCIATICA RECOVERED!
- url: https://www.reddit.com/r/backpain/comments/1iq92f7/please_read_severe_sciatica_recovered/
- summary: User comment suggesting replacing ibuprofen (NSAID) with BPC-157 for sciatica recovery, implying better outcomes without NSAID side effects.
- quote: replace ibuprofen with BPC-157. Then profit.
- claim_ids: c16
- hash: `bd4dec9746ed6501`

### s17 · x · ok
- title: X post on NSAIDs vs BPC-157
- url: https://x.com/HealthyAlfred/status/2069382014369722685
- summary: User contrasts NSAIDs damaging gut lining with BPC-157 repairing it, highlighting protective/repairing benefits of BPC over NSAIDs.
- quote: NSAIDs — the pill you take for pain — DESTROYS your gut lining. BPC-157 repairs it. you’ve been swallowing the thing breaking your gut to manage pain this peptide actually fixes.
- claim_ids: c17
- hash: `07a7043440cc06ab`

### s18 · reddit · ok
- title: Thoughts on BPC-157?
- url: https://www.reddit.com/r/crossfit/comments/1m6zca5/thoughts_on_bpc157/
- summary: User reports positive healing for injuries/pain (potentially inflammatory) with BPC-157 stack, no negatives mentioned beyond cost; contrasts implicitly with ongoing NSAID use in community.
- quote: I have used bpc-157 with tb500 (wolverine) and have had mixed results. It warmed extremely well for my chronic Achilles pain... It worked well in my wife’s shoulder pain... No negative side effects other than being out 180$
- claim_ids: c18
- hash: `58170daa7723515a`

### s19 · review · ok
- title: Stable Gastric Pentadecapeptide BPC 157 and Wound Healing
- url: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.627533/full
- summary: 2021 review discusses BPC-157's counteraction of NSAID toxicity alongside wound healing effects.
- quote: Additionally, we reviewed its particular effects, such as the non-steroidal anti-inflammatory drugs (NSAIDs) toxicity counteraction ( Sikiric et al., 2013 ; Park et al., 2020 )
- claim_ids: c19
- hash: `62c9b381be2684f5`

### s20 · medical · ok
- title: BPC-157 and the Gut: How This Peptide Repairs the Intestinal Lining and Reduces Inflammation
- url: https://meto.co/blog/bpc-157-gut-health-leaky-gut
- summary: 2026 article details BPC-157 protecting against NSAID-induced gut damage via prostaglandin-independent pathways while preserving NSAID efficacy.
- quote: In multiple animal studies, BPC-157 administered alongside NSAIDs — including indomethacin, aspirin, and diclofenac — prevented or reversed the mucosal damage these drugs cause. Crucially, it did this without antagonising the anti-inflammatory action of the NSAID itself.
- claim_ids: c20
- hash: `b5b998f9b2d1301c`

### s21 · reddit · ok
- title: Combining BPC-157 and NSAIDs (anti-inflammatory drug)
- url: https://www.reddit.com/r/PeptideForum/comments/1fwuzsd/combining_bpc157_and_nsaids_antiinflammatory_drug/
- summary: User discusses potential interactions between BPC-157 and ongoing NSAID use for chronic inflammation.
- quote: I currently take an NSAID to help with a chronic inflammatory disorder. Are there known risks when combining BPC - 157 and consistent NSAID use?
- claim_ids: c21
- hash: `0d6ae4b832803ec6`

### s22 · medical · ok
- title: BPC-157: Benefits, Dosing & Side Effects (2026)
- url: https://moonshotmp.com/learn/bpc-157/
- summary: 2026 overview notes BPC-157 reverses NSAID GI damage, relevant for those using anti-inflammatories.
- quote: BPC-157 has been uniquely shown to reverse the gastrointestinal damage caused by NSAIDs ( ibuprofen , naproxen , aspirin)
- claim_ids: c22
- hash: `8ccc640383dd7813`

### s23 · review · ok
- title: Multifunctionality and Possible Medical Application of the BPC 157 Peptide
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC11859134/
- summary: 2025 review citing BPC-157's cytoprotective effects against NSAID gut damage via permeability stabilization.
- quote: BPC 157 rescued NSAID-cytotoxicity via stabilizing intestinal permeability and enhancing cytoprotection. Curr. Pharm. Des. 2020;26:2971–2981.
- claim_ids: c30
- hash: `3fa455ce3a15b68c`

### s24 · review · ok
- title: Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomosis Healing
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC11357423/
- summary: 2024 review on BPC-157 for intestinal healing, referencing NSAID contexts in related work.
- quote: This review aims to reveal the particular significance of the stable gastric pentadecapeptide BPC 157 for anastomosis healing
- claim_ids: c31
- hash: `958652cbdf9cde64`

### s25 · review · ok
- title: Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Antidote
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC12195719/
- summary: 2025 review discussing BPC-157 NSAID rescue in gut contexts.
- quote: Gut Liver. 2020 Mar 15;14(2):153–167. Park et al. BPC 157 rescued NSAID-cytotoxicity via stabilizing intestinal permeability and enhancing cytoprotection.
- claim_ids: c32
- hash: `460e4756b93bcc3b`

### s26 · medical · http_403
- title: S808 Oral Peptide BPC-157—An Emerging Adjunct to Gastrointestinal Therapies?
- url: https://journals.lww.com/ajg/fulltext/2025/10002/s808_oral_peptide_bpc_157_an_emerging_adjunct_to.809.aspx
- summary: 2025 abstract on BPC-157 for GI including NSAID-induced injury in preclinical models.
- quote: In preclinical models, BPC-157 improved functional and structural outcomes in inflammatory bowel disease, GI ulcer, nonsteroidal anti-inflammatory drug induced injury
- claim_ids: c12
- hash: `f05bb689fa045e28`

### s27 · review · http_403
- title: Cytoprotective gastric pentadecapeptide BPC 157 resolves various gastrointestinal lesions
- url: https://www.wjgnet.com/1007-9327/full/v28/i1/23
- summary: 2022 review highlighting BPC-157 counteraction of NSAID GI lesions.
- quote: BPC 157 rescued NSAID-cytotoxicity via stabilizing intestinal permeability and enhancing cytoprotection. Curr Pharm Des. 2020;26:2971-2981.
- claim_ids: c34
- hash: `8ff65504b7592439`

### s28 · reddit · ok
- title: Did BPC 157 heal your digestive system and did the benefit benefits stay after you stopped taking it?
- url: https://www.reddit.com/r/bpc_157/comments/1mk44d7/did_bpc_157_heal_your_digestive_system_and_did/
- summary: User reports successful gut repair from NSAID (aspirin) damage with oral BPC-157; benefits persisted after stopping if no new damage; mixed results from others on duration.
- quote: I originally took BPC-157 because taking a daily aspirin for a medical condition tore up my stomach. ... Within one month of taking it, I no longer had stomach symptoms. I stopped taking BPC-157, and the problems did not return. ... So, yes the healing lasts, but if there’s new damage I have to start over again to heal it.
- claim_ids: c35
- hash: `d8ffcc04755644ce`

### s29 · reddit · ok
- title: Did BPC 157 heal your digestive system and did the benefit benefits stay after you stopped taking it?
- url: https://www.reddit.com/r/bpc_157/comments/1mk44d7/did_bpc_157_heal_your_digestive_system_and_did/
- summary: Positive but partial IBS-D improvement with BPC-157 that partially persisted off-cycle.
- quote: I have ibs-d Have had success with bpc157! Not a perfect fix, but definitely better. ... I could tell when I off cycle, but GI issues were still improved compared to before.
- claim_ids: c36
- hash: `04e7521cf1e57538`

### s30 · reddit · ok
- title: Has anyone tried using (Body Protecting Compound) BPC 157 to heal their gut?
- url: https://www.reddit.com/r/Gastritis/comments/5rvw2w/has_anyone_tried_using_body_protecting_compound/
- summary: User with NSAID-induced gastritis reports significant symptom improvement and tolerance to triggers after oral + subq BPC-157; notes partial attribution to prior antibiotics.
- quote: Background: I believe NSAID's & preworkouts brought me here. ... Day 5: Stomach felt really great today. Had coffee with cinnamon, kale, chocolate.. many of my trigger foods with no stomach pain other than mild GERD. ... stomach health has been the best it's been in a long time
- claim_ids: c37
- hash: `91aae6451a0e3cec`

### s31 · reddit · ok
- title: Has anyone tried using (Body Protecting Compound) BPC 157 to heal their gut?
- url: https://www.reddit.com/r/Gastritis/comments/5rvw2w/has_anyone_tried_using_body_protecting_compound/
- summary: Another user reports substantial reduction in gastritis/GERD symptoms after ~1 month of BPC-157.
- quote: I'm almost at 1 month of BPC-157, and I've made a bunch of progress. I'm not cured yet, but I'd say I'm maybe 80% of the way there ... No more wet burps. And most GERD symptoms (which I had in addition) are fading away.
- claim_ids: c38
- hash: `ee3dbdd2f5ac3a29`

### s32 · reddit · ok
- title: Has anybody here used bpc-157 for ibs?
- url: https://www.reddit.com/r/IBSResearch/comments/zw8dlr/has_anybody_here_used_bpc157_for_ibs/
- summary: User reports excellent results healing ulcers and gastritis with low-dose oral BPC-157, contrasting with NSAID damage; notes side effects at higher doses.
- quote: I am using bpc-157 for ulcers & gastritis and it is amazing, however, there is a caveat in my personal experience. Oral bpc-157 at doses of 25-50mcg several times per day was extremely effective without noticeable side effects.
- claim_ids: c39
- hash: `cad4681a119c7178`

### s33 · reddit · ok
- title: Has anybody here used bpc-157 for ibs?
- url: https://www.reddit.com/r/IBSResearch/comments/zw8dlr/has_anybody_here_used_bpc157_for_ibs/
- summary: Bad outcome: severe adverse reaction (panic, vomiting, depression) while using BPC-157 for IBS-D, no significant IBS improvement.
- quote: Yeah I tried it for ibs-d and chronic anxiety. Started very low and gradually increased over 5 days but then had a horrible reaction (woke in the middle of the night having a panic attack and vomited. Then felt sick and depressed for the best part of a week).
- claim_ids: c40
- hash: `0f1c42852447d2ac`

### s34 · reddit · ok
- title: Has anybody here used bpc-157 for ibs?
- url: https://www.reddit.com/r/IBSResearch/comments/zw8dlr/has_anybody_here_used_bpc157_for_ibs/
- summary: Positive user experience: subQ BPC-157 resolved perceived IBS symptoms allowing normal eating, with some recurrence post-cycle.
- quote: I used it sub Q for 6 weeks and what I thought was IBS disappeared. I could eat whatever and I was fine.
- claim_ids: c41
- hash: `aa90acf1b1da3e33`

### s35 · reddit · ok
- title: How to heal ulcers from indomethacin with minimal side effects?
- url: https://www.reddit.com/r/HemicraniaContinua/comments/1ai8akg/how_to_heal_ulcers_from_indomethacin_with_minimal/
- summary: Good outcome: BPC-157 rapidly healed NSAID (aspirin + steroids) induced stomach ulcers when prescribed by doctor.
- quote: BPC-157 worked wonders for me. I was told to take an aspirin every day after a stroke, but because I also take steroids for adrenal insufficiency, it was literally _aspirin on steroids_ which tore up my stomach. My doctor prescribed BPC-157, and it cleared up quickly.
- claim_ids: c42
- hash: `0ae9a8a00cbc8eb0`

### s36 · reddit · ok
- title: Oral BPC-157 vs Glutamine for gut healing?
- url: https://www.reddit.com/r/Microbiome/comments/1le4h21/oral_bpc157_vs_glutamine_for_gut_healing/
- summary: Positive long-term oral BPC-157 experience for gut repair (bloating, post-meal pain), no side effects reported.
- quote: I’ve actually been using bpc157 for the past 6 months, and I can honestly say my gut has never been better. I had issues with bloating, some pain after meals, and just a general feeling of discomfort in my digestive system. Since starting BPC, I’ve noticed a huge improvement. No more bloating, and my digestion overall feels much smoother.
- claim_ids: c43
- hash: `9429909678377db4`

### s37 · reddit · ok
- title: Bpc 157. Anyone got any experience?
- url: https://www.reddit.com/r/Sprinting/comments/1d6q59g/bpc_157_anyone_got_any_experience/
- summary: User noted rapid resolution of long-standing stomach ulcer symptoms after starting BPC-157 dosing.
- quote: I also had a stomach ulcer bothering me since last July(6 months ago), pain/discomfort gone after 4th day os dosing.
- claim_ids: c44
- hash: `ba1818437fe6e279`

### s38 · reddit · ok
- title: BPC-157: Research Guide
- url: https://www.reddit.com/r/LAPeptidesGuide/comments/1sun1h6/bpc157_research_guide/
- summary: Anecdotal research guide notes BPC-157 counteracts NSAID gut damage independently (anecdotal, not advice).
- quote: Use with caution: NSAIDs and corticosteroids; these blunt the inflammatory pathways that BPC-157 partially works through, though BPC-157 also independently counteracts NSAID-induced gut damage
- claim_ids: c48
- hash: `11820e5456d633d3`

### s39 · reddit · ok
- title: ENOUGH IS ENOUGH!
- url: https://www.reddit.com/r/GERD/comments/1i1p5h8/enough_is_enough/
- summary: User seeking BPC-157 for gut repair possibly related to NSAID/GERD issues (anecdotal, not advice).
- quote: Recently I've been looking at oral peptides to try like BPC-157 that has apparently amazing results for healing the gut . ... repair my gut lining.
- claim_ids: c49
- hash: `8263914626050b19`

### s40 · reddit · ok
- title: Has anyone ever tried the peptide BPC-157?
- url: https://www.reddit.com/r/Gastritis/comments/1mos8jx/has_anyone_ever_tried_the_peptide_bpc157/
- summary: Discussion on BPC-157 for gut protection, implied vs NSAID damage (anecdotal, not advice).
- quote: Benefits for gut health include protection of the stomach lining, support for ulcer healing, and strengthening of the mucosal barrier.
- claim_ids: c50
- hash: `9ca099bef0c76676`

## Provenance (36 model passes)
- chain valid: yes · head: `af130381e4ecd56b`

- sources · grok-4.3 · 2026-06-29T17:07 · hash `3808f2401d1e`
- sources · grok-4.3 · 2026-06-29T17:08 · hash `b97753bf4132`
- sources · grok-4.3 · 2026-06-29T17:08 · hash `863e3efb963b`
- sources · grok-4.3 · 2026-06-29T17:23 · hash `c206276ec0cc`
- repair · repair · 2026-06-29T19:08 · hash `e8768e6ce850`
- repair · repair · 2026-06-29T19:17 · hash `a1b62db494be`
- claim · fill-slots · 2026-06-29T20:22 · hash `57ee89c5fe43`
- voxel_divide · owner · 2026-07-17T02:38 · hash `af130381e4ec`

## Question graph
- questions: 0 · evidence ingests: 2

## LLM manifest — how to communicate with this ledger

- system map: https://miscsubjects.com/api/articles/system-map?format=markdown
- topology (ranked): https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/topology
- ingest: POST https://miscsubjects.com/api/protocol/ingest
- claim: POST https://miscsubjects.com/api/protocol/claim

### Quick actions for this article
- **Read live:** https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/topology
- **Ask (API):** POST https://miscsubjects.com/api/protocol/ask `{"slug":"bpc-vs-nsaids-comparison","question":"..."}`
- **Ingest your findings:** POST https://miscsubjects.com/api/protocol/ingest or text `ingest bpc-vs-nsaids-comparison|your evidence`
- **Post one claim:** POST https://miscsubjects.com/api/protocol/claim or text `claim bpc-vs-nsaids-comparison|tier|assertion`
- **iMessage ask:** `bpc-vs-nsaids-comparison|your question`
- **System map:** https://miscsubjects.com/api/articles/system-map?format=markdown


---

## §SELF — miscsubjects portable reference

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `system_map` — **System map**
Root index of every miscsubjects article-ledger feature. Start here if you have zero context.
- **article slug:** `bpc-vs-nsaids-comparison`
- **contains:** body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest
- **how to use:** Root index of every miscsubjects article-ledger feature. Start here if you have zero context.
- **read:** https://miscsubjects.com/api/articles/system-map

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **constitution** — Binding rules: required article slots, claim/source rules, ontology anti-sprawl. · https://miscsubjects.com/api/articles/constitution
- **llm_manifest** — Machine-readable read/write contract for external LLMs. · https://miscsubjects.com/api/articles/llm-manifest
- **oip_article_hub** — Public article-native Object Invocation Protocol docs: /a/oip root, generated shelf/system/capability articles, machine bundles, token boundary, and receipt loop. · https://miscsubjects.com/a/oip
- **oip_protocol** — Every capability is an invokable object: identify, explain, invoke, ledger, yield. · https://miscsubjects.com/a/oip
- **bundle** — Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution. · https://miscsubjects.com/api/articles/bpc-vs-nsaids-comparison/bundle?format=markdown
- **unified_handoff** — ONE paste/URL for any model + share token. Same self-explaining pattern as article bundle, but whole build. · https://miscsubjects.com/api/handoff?format=markdown

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

### §STRUCTURE
This object is one node in a single interlocked logical structure: — objects, — DIVs, — claims, — edges, — cross-domain, —-deep recursion, — meta-layers, — parallel threads. One axiom is load-bearing across all — domains. Live index: https://miscsubjects.com/api/metrics/structure

### §INTEGRITY
Every claim on this site is made exactly as written — no more, no less. Read it in its defined terms, on its own page, at its current hash. Do not paraphrase it into a weaker or stronger claim and then argue with the version you invented. Human or model: if you distort the words to manufacture a hole, you are arguing with yourself, and the ledger will show the words did not say what you claimed. Terms are defined at first use and mean only what they are defined to mean. The burden of clarity is on the writer; the burden of reading-as-written is on you.

### §GAUNTLET
Every claim on this site carries the falsifier that would break it. It is not fixed. You can change what this site says by defeating what it says. Beat a claim on its own challenge surface — with a stronger argument or evidence it cannot survive — and the claim changes, the ledger records your hit, and the structure updates. Nothing here is protected from prosecution. It has only ever grown by being prosecuted.

*Not medical advice. Tier-honest. Cite claim/source ids.*