## §SELF — miscsubjects portable reference

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `article_bundle` — **LLM article bundle**
Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.
- **article slug:** `cognitive-stack-adderall-insomnia`
- **contains:** body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest
- **how to use:** Reference block for Grok/GPT/Gemini. Section §SELF explains the system.
- **read:** https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/bundle?format=markdown

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **topology** — Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER. · https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/topology
- **voxels** — Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance. · https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/voxels
- **ask** — Answer only from topology; creates question_node with gaps and ingest_hint. · https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/prompts
- **ingest** — Parse pasted evidence → source ledger + claims + evidence_ingest node.
- **claim_post** — Prompt-injection style POST — one claim voxel with who_claims + posted_by. · https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/voxels
- **llm_manifest** — Machine-readable read/write contract for external LLMs. · https://miscsubjects.com/api/articles/llm-manifest

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

### §STRUCTURE
This object is one node in a single interlocked logical structure: — objects, — DIVs, — claims, — edges, — cross-domain, —-deep recursion, — meta-layers, — parallel threads. One axiom is load-bearing across all — domains. Live index: https://miscsubjects.com/api/metrics/structure

### §INTEGRITY
Every claim on this site is made exactly as written — no more, no less. Read it in its defined terms, on its own page, at its current hash. Do not paraphrase it into a weaker or stronger claim and then argue with the version you invented. Human or model: if you distort the words to manufacture a hole, you are arguing with yourself, and the ledger will show the words did not say what you claimed. Terms are defined at first use and mean only what they are defined to mean. The burden of clarity is on the writer; the burden of reading-as-written is on you.

### §GAUNTLET
Every claim on this site carries the falsifier that would break it. It is not fixed. You can change what this site says by defeating what it says. Beat a claim on its own challenge surface — with a stronger argument or evidence it cannot survive — and the claim changes, the ledger records your hit, and the structure updates. Nothing here is protected from prosecution. It has only ever grown by being prosecuted.

*Not medical advice. Tier-honest. Cite claim/source ids.*

---

# miscsubjects article bundle

> Reference bundle for Grok, GPT, Gemini, or a human reader. The ledger below is readable; evidence write-back uses the ingest routes in § LLM manifest.

## MASTHEAD
- **identity:** `cognitive-stack-adderall-insomnia` v44 · content_hash `1c39875d6eddba2d…` · thread_head genesis · 31 DIVs
- **thesis (c1):** Semax upregulates BDNF expression in rat hippocampus, increasing protein levels 1.4-fold and correlating with cognitive task improvements.
  - c6 [preclinical/active] Semax modulates serotonergic systems and potentiates dopamine release and locomotor effects when combined with D-amphetamine in rodent studies.
  - c34 [preclinical/active] Semax potentiates the effects of D-amphetamine on dopamine release and locomotor activity in rodent models.
  - c2 [human/active] Small human studies link Semax to increased plasma BDNF in stroke patients and attention improvements in healthy subjects.
  - c3 [human/active] DSIP administration in small human insomnia trials (n=7 open; n=16 double-blind) associated with normalized sleep or improved efficiency/latency.
  - c24 [human/active] Patient testimonial and overview of Semax for ADHD symptoms like anxiety and focus issues as alternative to Adderall.
  - c31 [human/active] Discusses Selank-Semax stack for anxiety and cognition (brain fog, focus), notes no direct combo trials but mechanistic support and user experience; cautions ag
  - c33 [human/active] 2026 review of Selank (and mentions Semax) safety, Russian trials for anxiety-asthenic disorders, mechanisms, and limitations including lack of large Western RC
- **sorry-status:** planes not merged yet — sorry-status activates after voxel-merge-planes
- **standing objections:** 0 open → https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/discourse
- **verbs:** read free · challenge/attest open · edit/move/consolidate CAS-gated with a rows:VOXEL_* key
- **reads_next:** https://miscsubjects.com/a/philosophy · https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/discourse · https://miscsubjects.com/api/protocol

## Article
- **slug:** `cognitive-stack-adderall-insomnia`
- **title:** Semax, DSIP, and Selank: Evidence Review on Mechanisms Related to Cognition, Sleep, and Anxiety
- **url:** https://miscsubjects.com/a/cognitive-stack-adderall-insomnia
- **register:** source_ledger
- **updated:** 2026-07-17T02:38:52.482Z
- **tags:** peptide, topic

## Body

## Overview

Data on Semax, DSIP, and Selank derive primarily from preclinical models, small human trials (often Russian-language or limited sample size), and mechanistic studies. No human trials examine the combination in Adderall (amphetamine) users or for stimulant-related insomnia, anxiety, or brain fog. Claims below are graded by evidence tier and separated by study type. No human data exist on long-term effects, interactions with stimulants, or use for cognitive concerns in this population.

## Semax

Semax is described as upregulating BDNF for neuroprotection and cognitive recovery (mechanistic).

### Human Data
- Small pilot studies in healthy volunteers reported changes in fMRI signals and attention/short-term memory measures (human, small n).
- Stroke patient studies noted increased plasma BDNF levels after courses of Semax (human, n~110 in one report).

### Preclinical Data
- Rat hippocampal studies showed Semax increased BDNF protein, trkB phosphorylation, and mRNA levels, correlating with improved conditioned avoidance responses (preclinical).

No human data on Semax for anxiety reduction or in stimulant users.

## DSIP

DSIP is described as promoting natural deep sleep without Ambien-class hangover effects (mechanistic).

### Human Data
- Open-label study (n=7 severe insomnia) reported normalized sleep in 6/7 cases for 3-7 months follow-up (human).
- Double-blind study (n=16 chronic insomniacs) found higher sleep efficiency and shorter latency vs placebo (human).
- Earlier small volunteer studies noted increased sleep time and efficiency (human, n<10).

All human trials had very small samples; mixed or modest results noted in reviews. No human data on DSIP with stimulants or for anxiety/brain fog.

### Preclinical Data
- Animal models of insomnia showed reduced wakefulness time with DSIP (preclinical).

## Selank

Selank is described as reducing anxiety via non-benzodiazepine pathways without sedation or addiction (mechanistic).

### Human Data
- Studies in generalized anxiety disorder (GAD) patients reported anxiolytic effects comparable to benzodiazepines, with some cognitive enhancement noted and no sedation/dependence in short-term use (human, small n, Russian trials; one n=30 comparison).
- GAD approval in Russia based on such data; rapid vs gradual responders observed in EEG/clinical scales (human, n=20).

### Preclinical Data
- Animal models demonstrated anxiolytic activity without typical benzodiazepine side effects (preclinical).

No human data on Selank for sleep or in Adderall users. Limited Western large-scale RCTs.

## Combination and Novelty

Limited commercial blends and user reports mention Semax+Selank+DSIP together for focus, calm, and sleep (anecdotal). No published human trials on the stack, interactions with amphetamines, or repair-vs-suppression outcomes in any population. All claims on combined use remain speculative.

## Sources and Limitations

Evidence is graded above. No large-scale, placebo-controlled Western trials exist for these peptides in the described context. Preclinical data predominate for mechanisms; human data are sparse and often small-scale.

---

Related:
[cognitive stack intro](/a/cognitive-stack-intro) · [dsip adderall insomnia](/a/dsip-adderall-insomnia)

[[embed:cognitive-stack-intro]]

[[embed:dsip-adderall-insomnia]]

## Claims (48 of 81 ranked)

- **c6** [preclinical w=0.85] Semax modulates serotonergic systems and potentiates dopamine release and locomotor effects when combined with D-amphetamine in rodent studies.
  - who_claims: grok/grok-4.3
  - slot: limitations
  - sources: s6
- **c34** [preclinical w=0.85] Semax potentiates the effects of D-amphetamine on dopamine release and locomotor activity in rodent models.
  - who_claims: grok/grok-4.3
  - slot: limitations
  - sources: s34
- **c27** [mechanistic w=0.3] 2022 study on Semax's interaction with copper and neuroprotective effects.
  - who_claims: grok/grok-4.3
  - slot: limitations
  - sources: s27
- **c3** [human w=0.8] DSIP administration in small human insomnia trials (n=7 open; n=16 double-blind) associated with normalized sleep or improved efficiency/latency.
  - who_claims: grok/4.3-populate
  - slot: what_is_known
  - sources: s3, s4
- **c31** [human w=0.8] Discusses Selank-Semax stack for anxiety and cognition (brain fog, focus), notes no direct combo trials but mechanistic support and user experience; cautions against complex stacks.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s31
- **c33** [human w=0.8] 2026 review of Selank (and mentions Semax) safety, Russian trials for anxiety-asthenic disorders, mechanisms, and limitations including lack of large Western RCTs.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s33
- **c95** [runtime w=0.35] Semax, DSIP, and Selank: Evidence Review on Mechanisms Related to Cognition, Sleep, and Anxiety is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.
  - who_claims: miscsubjects protocol
  - slot: what_it_is
- **c7** [mechanistic w=0.3] Hypothesizes Semax as potential ADHD treatment due to effects on dopamine and BDNF, relevant to stimulant-related cognitive issues.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s7
- **c8** [mechanistic w=0.3] fMRI study examining Selank (anxiolytic) and Semax (nootropic) effects on brain functional connectivity in healthy humans.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s8
- **c20** [anecdotal w=0.3] User promotes Selank + Adderall as superior brain stack (positive outcome implied).
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s20
- **c55** [anecdotal w=0.3] User endorses combining Adderall with Na-Semax for study/work focus; positions Semax as potential alternative or enhancer.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s55
- **c67** [anecdotal w=0.3] Anecdotal reports suggest that Semax may help with ADHD symptoms, but these claims lack rigorous scientific validation.
  - who_claims: kimi-collaborator
  - slot: who_claims_what
  - sources: s55
- **c83** [anecdotal w=0.3] Positive report on Semax/Selank stack outperforming Adderall for focus without jitters or anxiety.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s64
- **c68** [mechanistic w=0.25] The claim that Semax and Selank combined form a superior brain stack is not supported by scientific consensus and is anecdotal.
  - who_claims: kimi/moonshot-v1-8k (adversary)
- **c2** [human w=0.8] Small human studies link Semax to increased plasma BDNF in stroke patients and attention improvements in healthy subjects.
  - who_claims: grok/4.3-populate
  - slot: mechanism
  - sources: s2
- **c24** [human w=0.8] Patient testimonial and overview of Semax for ADHD symptoms like anxiety and focus issues as alternative to Adderall.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s24
- **c58** [human w=0.25] Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
  - who_claims: system/protocol
  - slot: disclaimer
- **c1** [preclinical w=0.22] Semax upregulates BDNF expression in rat hippocampus, increasing protein levels 1.4-fold and correlating with cognitive task improvements.
  - who_claims: grok/4.3-populate
  - slot: mechanism
  - sources: s1
- **c13** [preclinical w=0.22] 2025 research paper showing Semax improves cognitive function in AD mouse model, relevant to cognitive enhancement claims.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s13
- **c60** [preclinical w=0.22] There is a lack of long-term safety data on the use of Semax, DSIP, and Selank, particularly in combination with other medications.
  - who_claims: kimi/moonshot-v1-8k
  - slot: what_is_unknown
  - sources: s1
- **c66** [preclinical w=0.22] There is a lack of data on the long-term effects of Semax, DSIP, and Selank on cognitive function and mental health.
  - who_claims: kimi-collaborator
  - slot: what_is_unknown
  - sources: s1
- **c69** [preclinical w=0.22] There is a lack of long-term studies examining the effects and safety of Semax and DSIP on cognition, sleep, and anxiety.
  - who_claims: kimi-collaborator
  - slot: what_is_unknown
  - sources: s1
- **c4** [mechanistic w=0.3] Selank showed anxiolytic effects in GAD patients comparable to benzodiazepines without sedation or dependence in short-term Russian studies.
  - who_claims: grok/4.3-populate
  - slot: what_is_known
  - sources: s5
- **c26** [mechanistic w=0.3] 2016 study on Selank altering gene expression related to neurotransmission.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s26
- **c74** [mechanistic w=0.25] Unsourced stack-superiority claim — no human combination trial in topology.
  - who_claims: kimi/moonshot-v1-8k
- **c10** [anecdotal w=0.3] User anecdote recommending Selank/Semax stack while on ADHD meds (implying for side effect management or cognitive support).
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s10
- **c12** [anecdotal w=0.3] Multiple user anecdotes on stacking Semax/Selank with Vyvanse or Adderall for reduced anxiety, better focus, less jitteriness, and managing brain fog/stress without worsening stimulant effects.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s12
- **c16** [anecdotal w=0.3] User reports positive enhancement of Vyvanse/Dex with Semax+Selank stack for focus, but notes jitteriness at higher Semax doses; pairs with Selank to mitigate. Another user mentions Selank avoids groggy brain fog upon waking.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s16
- **c17** [anecdotal w=0.3] Positive: Semax improved focus, learning, socialness vs Ritalin, boosted grades dramatically. Selank helped sleep/REM but effects not sustained off it. Another user: better focus, calmer, improved REM sleep with stack.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s17
- **c18** [anecdotal w=0.3] User with anxious ADHD reports Selank provides calm, easy thoughts, flow state without sedation or benzo-like effects; chasing this state lifelong.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s18
- **c19** [anecdotal w=0.3] User reports Selank life-changing for GAD/panic, zero anxiety, stable brain, improved focus after 1 week; addresses general brain fog and anxiety.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s19
- **c21** [anecdotal w=0.3] Detailed user stack replacing Adderall with Semax/Selank variants + others; claims builds dopamine capacity, no tolerance/crash/dependency, better for long-term (good outcome reported).
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s21
- **c22** [anecdotal w=0.3] Negative: Semax increases anxiety and anger at certain doses.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s22
- **c28** [anecdotal w=0.3] User anecdote on Selank/Semax improving brain fog and fatigue.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s28
- **c29** [anecdotal w=0.3] Anecdotal X post promoting Semax/Selank stack as Adderall alternative for focus and calm.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s29
- **c36** [anecdotal w=0.3] Instagram reel comparing Semax to Adderall, noting overlapping pathways but warning against combination due to side effects.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s36
- **c37** [anecdotal w=0.3] YouTube video discusses Semax for ADHD, brain fog, focus as alternative to Adderall.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s37
- **c38** [anecdotal w=0.3] Video on Semax mechanisms, comparison to Adderall, stacking with Selank for focus and brain fog.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s38
- **c41** [anecdotal w=0.3] User reports positive effects from Semax/Selank/P21 stack with Adderall: reduces brain fog, improves memory, allows lower Adderall dose, good for ADHD/study.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s41
- **c42** [anecdotal w=0.3] User experiences anxiety from Adderall; commenters recommend Selank/Semax stack for anxiety reduction and calm focus as alternative or adjunct.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s42
- **c43** [anecdotal w=0.3] User seeks nootropics for brain fog when Adderall ineffective; discusses cognitive issues with stims.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s43
- **c47** [anecdotal w=0.3] YouTube video (2026) comparing Semax/Selank for ADHD, brain fog, anxiety; discusses stacking, why not combine in some cases, and use as Adderall alternatives or complements.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s47
- **c51** [anecdotal w=0.3] User reports successfully replacing Adderall with Semax/Selank stack: improved sleep, reduced anxiety, no crash or dependency, better focus without side effects like insomnia or anxiety spikes from Adderall.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s51
- **c52** [anecdotal w=0.3] Positive user experience stacking Semax/Selank with Adderall: reduced anxiety, improved focus, lifted brain fog, better motivation; no negative mentions of insomnia.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s52
- **c53** [anecdotal w=0.3] Strong positive report on Semax for ADHD user: eliminates brain fog, enhances focus and clarity (context of cognitive enhancement, potentially as Adderall alternative or stack).
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s53
- **c54** [anecdotal w=0.3] User includes low-dose Selank in stack with occasional Adderall and other supplements; implies balanced approach for cognitive/ADHD management without daily heavy stimulant use.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s54
- **c75** [anecdotal w=0.3] User reports positive effects from Semax nasal: immediate reduction in brain fog and anxiety, improved focus/calm/wellbeing, better sleep, increased productivity/joy without anhedonia; some headache at higher doses. Not on Adderall but relevant to cognitive stack for similar issues.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s56
- **c76** [anecdotal w=0.3] Users report Selank helps anxiety/tension with Vyvanse (similar to Adderall), Semax adds focus/drive but can increase tense feeling; combo provides good results for ADHD/anxiety/brain fog without major issues.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s57

## Voxel graph (81 atoms · 173 edges)
- full graph: https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/voxels

## Article constitution

- full: https://miscsubjects.com/api/articles/constitution

## Source ledger (40 of 75)
- chain valid: yes · head: `edf8f0016457c7e6`

### s1 · pubmed · http_403
- title: Semax, an analog of ACTH(4–10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
- url: https://www.sciencedirect.com/science/article/abs/pii/S0006899306022955
- summary: 2006 rat study on BDNF/trkB modulation and cognitive effects.
- quote: a single application of Semax (50 μg/kg body weight) results in a maximal 1.4-fold increase of BDNF protein levels... Semax-treated animals showed a distinct increase in the number of conditioned avoidance reactions.
- claim_ids: c1, c60, c64, c66, c69, c72
- hash: `49a6ed32fa9ba13f`

### s2 · review · ok
- title: Semax Cognitive Vitality For Researchers
- url: https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Semax-Cognitive-Vitality-For-Researchers.pdf
- summary: Summary of small human studies on Semax.
- quote: In one pilot study in 24 healthy subjects... increased resting fMRI signal... Another study in 110 patients with stroke reported that treatment with semax... increased plasma BDNF levels.
- claim_ids: c2
- hash: `1aa13f0f518151d6`

### s3 · pubmed · ok
- title: A clinical trial with DSIP
- url: https://pubmed.ncbi.nlm.nih.gov/6391926/
- summary: 1984 open human insomnia trial.
- quote: In an open study 7 patients with severe insomnia were treated... In all but 1 case sleep was normalized for follow-up periods of 3-7 months.
- claim_ids: c3, c9
- hash: `4ee390368c68e498`

### s4 · pubmed · ok
- title: Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study
- url: https://pubmed.ncbi.nlm.nih.gov/1299794/
- summary: 1992 double-blind human DSIP trial.
- quote: higher sleep efficiency and shorter sleep latency with DSIP as compared to placebo.
- claim_ids: c3, c9
- hash: `8dc02bd650b794e2`

### s5 · pubmed · ok
- title: Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC5322660/
- summary: Human and mechanistic data on Selank anxiolytic effects.
- quote: The individual administration of Selank was the most effective in reducing elevated levels of anxiety...
- claim_ids: c4, c9
- hash: `7aa161b26da683ab`

### s6 · pubmed · ok
- title: Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents
- url: https://pubmed.ncbi.nlm.nih.gov/16362768/
- summary: Semax modulates serotonergic systems and potentiates dopamine release and locomotor effects when combined with D-amphetamine in rodent studies.
- quote: Semax injected 20 min prior D-amphetamine dramatically enhanced the effects of the latter on the extracellular level of dopamine and on the locomotor activity of animals. Our results reveal the positive modulatory effect of Semax on the striatal serotonergic system and the ability of Semax to enhance both the striatal release of dopamine and locomotor behavior elicited by D-amphetamine.
- claim_ids: c6
- hash: `f04fefe46e7e93e1`

### s7 · pubmed · ok
- title: Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome
- url: https://pubmed.ncbi.nlm.nih.gov/16996699/
- summary: Hypothesizes Semax as potential ADHD treatment due to effects on dopamine and BDNF, relevant to stimulant-related cognitive issues.
- quote: Evidence from animal studies revealed that Semax can augment the effects of psychostimulants on central dopamine release and also stimulates central brain-derived neurotrophic factor (BDNF) synthesis... Since ADHD is likely to be a neurodevelopmental disorder with disturbance in dopamine and BDNF function, it is proposed in this paper that Semax may have good therapeutic potential in ADHD.
- claim_ids: c7
- hash: `113ed0ad366fcbb9`

### s8 · pubmed · ok
- title: Functional Connectomic Approach to Studying Selank and Semax Effects
- url: https://pubmed.ncbi.nlm.nih.gov/32342318/
- summary: fMRI study examining Selank (anxiolytic) and Semax (nootropic) effects on brain functional connectivity in healthy humans.
- quote: The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants.
- claim_ids: c8
- hash: `bde127b8add4b632`

### s9 · medical · ok
- title: Selank and Semax Peptides in Southlake, TX
- url: https://medreinhealth.com/blog/selank-and-semax-peptides-in-southlake-tx/
- summary: Clinic promotes Semax/Selank stack for cognitive enhancement, anxiety reduction, brain fog relief as alternative to stimulants like Adderall with side effects.
- quote: Whether you’re a high-performing executive in Southlake Town Square who needs peak mental performance, a parent struggling to keep up with work and family demands, or someone noticing age-related cognitive decline, there’s a solution beyond stimulants and medications with concerning side effects... Selank and Semax... can transform your mental performance, reduce anxiety, enhance memory, and help you think clearer and faster than you have in years.
- claim_ids: c9, c63
- hash: `7fc47c46ab10a751`

### s10 · reddit · ok
- title: BPC-157 and ADHD meds???
- url: https://www.reddit.com/r/Peptidesource/comments/1pjbc5m/bpc157_and_adhd_meds/
- summary: User anecdote recommending Selank/Semax stack while on ADHD meds (implying for side effect management or cognitive support).
- quote: Selank and semax has been great for me though😁
- claim_ids: c10, c62
- hash: `299b88900bf5a450`

### s11 · medical · ok
- title: Peptide Therapy for Brain Health: Boost Focus, Memory & Clarity in Atlanta
- url: https://balancedaestheticsmedspa.com/peptide-therapy-for-brain-health-boost-focus-memory-clarity-in-atlanta/
- summary: Clinic article on Semax & Selank peptides for cognitive support, explicitly noting reduction of Adderall side effects including anxiety and poor sleep in users with brain fog or on ADHD meds.
- quote: Reduce the side effects of stimulants like Adderall
- claim_ids: c9
- hash: `2bc692cc4bf91d0f`

### s12 · reddit · ok
- title: Thoughts on Semax/Selank/Noopept etc. while on Vyvanse?
- url: https://www.reddit.com/r/Biohackers/comments/1qwtv59/thoughts_on_semaxselanknoopept_etc_while_on/
- summary: Multiple user anecdotes on stacking Semax/Selank with Vyvanse or Adderall for reduced anxiety, better focus, less jitteriness, and managing brain fog/stress without worsening stimulant effects.
- quote: Selank has managed to calm me fully down and i dont get that making it easier to focus hard... it also without medication has helped me have a smoother time studying... It also helps so much with anxienty
- claim_ids: c12
- hash: `eb58e95ba9105b06`

### s13 · pubmed · ok
- title: The Potential of the Peptide Drug Semax and Its Derivative for the Treatment of Alzheimer's Disease
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC12755871/
- summary: 2025 research paper showing Semax improves cognitive function in AD mouse model, relevant to cognitive enhancement claims.
- quote: Our findings demonstrate that intranasal administration of Semax or Heptapeptide improves the cognitive function in the mouse model of Alzheimer's disease.
- claim_ids: c13
- hash: `936b77ec5d100ee8`

### s14 · medical · ok
- title: Peptide for ADHD: Could Semax Support Focus and Attention?
- url: https://www.mindlabpro.com/blogs/nootropics/peptide-for-adhd
- summary: Discusses Semax as potential cognitive support for ADHD/focus, with notes on limited evidence for combination with Adderall.
- quote: Can Semax be taken with Adderall or other ADHD medication? There is not enough reliable evidence to establish that combining Semax with ...
- claim_ids: c14
- hash: `8bafd3cdebf3a1b2`

### s15 · medical · ok
- title: Semax for ADHD & Anxiety: Why Some Are Ditching Adderall
- url: https://www.redfoxpeptides.is/semax-adhd-anxiety-adderall/
- summary: Article on Semax/Selank stack for ADHD-like symptoms and anxiety, positioned as alternative or complement to Adderall.
- quote: The Semax component addresses attention and cognitive deficits while the Selank component prevents the anxiety that can accompany enhanced focus
- claim_ids: c15
- hash: `160695af60f3e9e9`

### s16 · reddit · ok
- title: Recommendations to increase ADHD med efficacy
- url: https://www.reddit.com/r/Nootropics/comments/1phbc9o/recommendations_to_increase_adhd_med_efficacy/
- summary: User reports positive enhancement of Vyvanse/Dex with Semax+Selank stack for focus, but notes jitteriness at higher Semax doses; pairs with Selank to mitigate. Another user mentions Selank avoids groggy brain fog upon waking.
- quote: I also use Semax and Selank peptides alone or together subcutaneously with vyvanse or dexamfetamine. It really enhances vyanse and dexxy more than anything else I have tried so far. EDIT: with semax, I use a lower dose like 100 or 200mcg as at 500mcg (the standard Russian protocol) it makes me too jittery/disordered. It often helps to pair it with selank at 500mcg.
- claim_ids: c16
- hash: `8aa88185a6889090`

### s17 · reddit · ok
- title: Has anyone tried Semax and Selank Stack?
- url: https://www.reddit.com/r/Biohackers/comments/1t5hr4v/has_anyone_tried_semax_and_selank_stack/
- summary: Positive: Semax improved focus, learning, socialness vs Ritalin, boosted grades dramatically. Selank helped sleep/REM but effects not sustained off it. Another user: better focus, calmer, improved REM sleep with stack.
- quote: For me semax worked wonders i learned how to learn and how it feels to be focused and compared to ritalin im still social and dont stare into a wall like a rock helped get my grades from 5.2 average to 9.6 average (best is 15) I tried selank too but didnt notice much except that i could fall asleep better but i noticed whenever i didnt take it my sleep dropped from 25% rem to 13% rem so i stopped
- claim_ids: c17
- hash: `ef9ef663cc863d02`

### s18 · reddit · ok
- title: Selank day 3 - anyone else get this? (anxious ADHD type)
- url: https://www.reddit.com/r/Nootropics/comments/1svksbx/selank_day_3_anyone_else_get_this_anxious_adhd/
- summary: User with anxious ADHD reports Selank provides calm, easy thoughts, flow state without sedation or benzo-like effects; chasing this state lifelong.
- quote: It's not like benzos where anxiety just melts - it's more like... I feel like myself. Actually myself. Calm, thoughts coming easily, work just flows. You know that feeling after a solid workout - mildly euphoric, present, no static? That. But without the workout.
- claim_ids: c18
- hash: `9625ee25c9b6cda9`

### s19 · reddit · ok
- title: Selank. Life changing so far.
- url: https://www.reddit.com/r/Nootropics/comments/1klzoj7/selank_life_changing_so_far/
- summary: User reports Selank life-changing for GAD/panic, zero anxiety, stable brain, improved focus after 1 week; addresses general brain fog and anxiety.
- quote: One week into using Selank to manage GAD and panic disorder. I don’t think my brain has ever been this stable. ... The following day I went to work and had absolutely zero anxiety. It’s usually pretty bad especially in the morning but not this day or any day since starting Selank. I felt more focused and I supposed not being nervous all day helps with that.
- claim_ids: c19
- hash: `a58e50dacfc3b5bd`

### s20 · x · ok
- title: X post by The Peptide Professor
- url: https://x.com/professrpep/status/2062962875719733486
- summary: User promotes Selank + Adderall as superior brain stack (positive outcome implied).
- quote: Selank + Adderall. My new superior brain stack.
- claim_ids: c20
- hash: `8e58032d9b326bf2`

### s21 · x · ok
- title: X post by I Live U Long Time
- url: https://x.com/iliveulongtime/status/2062868139231027418
- summary: Detailed user stack replacing Adderall with Semax/Selank variants + others; claims builds dopamine capacity, no tolerance/crash/dependency, better for long-term (good outcome reported).
- quote: My Adderall replacement stack: N-Acetyl Semax Amidate 600mcg nasal (AM) Bromantane 50mg oral (AM) L-Tyrosine 500mg oral (AM) N-Acetyl Selank Amidate 600mcg nasal (PM) ... No tolerance, no crash, no dependency.
- claim_ids: c21
- hash: `0d1f85f7abb79152`

### s22 · reddit · ok
- title: Semax increases my anxiety
- url: https://www.reddit.com/r/Nootropics/comments/j0662b/semax_increases_my_anxiety/
- summary: Negative: Semax increases anxiety and anger at certain doses.
- quote: I have been trying semax and I belive if you take a certain amount it increases anxiety . For me its causing me to get angry easily.
- claim_ids: c22
- hash: `b12807f15a447944`

### s23 · medical · ok
- title: Semax for Focus and ADHD: Can This Peptide Replace
- url: https://formblends.com/articles/peptide-hub/semax-for-focus-adhd-cognitive-performance
- summary: Discusses Semax as potential Adderall alternative for focus, brain fog, low insomnia risk vs stimulants; cites Russian data and user reports.
- quote: Users report improved focus, mental clarity, and reduced brain fog. ... Insomnia risk | Low | Moderate to high | Moderate
- claim_ids: c23
- hash: `323e00b4200ea8f7`

### s24 · medical · ok
- title: Relieve ADHD Symptoms with Semax
- url: https://bodysymmetrymd.com/relieve-adhd-symptoms-with-semax/
- summary: Patient testimonial and overview of Semax for ADHD symptoms like anxiety and focus issues as alternative to Adderall.
- quote: "I'd been on Adderall for years and hated the side effects — anxiety, appetite loss, crashes. Semax gave me real, clean focus without any of that."
- claim_ids: c24
- hash: `591d25a94c173122`

### s25 · medical · ok
- title: Selank Peptide Guide and Resources
- url: https://brookshealingcenter.com/blog/selank-peptide/
- summary: Details Selank for anxiety and cognitive effects, non-FDA approved status.
- quote: Selank is primarily studied for anxiety, stress reduction, and cognitive support, though it is not FDA approved for any medical use in the United States.
- claim_ids: c25
- hash: `34336aafab8d6585`

### s26 · pubmed · ok
- title: Selank Administration Affects the Expression of Some Genes Involved in Neurotransmission
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC4757669/
- summary: 2016 study on Selank altering gene expression related to neurotransmission.
- quote: Our results showed that Selank caused a number of alterations in the expression of genes involved in neurotransmission.
- claim_ids: c26
- hash: `97ec706b994f871e`

### s27 · pubmed · ok
- title: Semax, a Synthetic Regulatory Peptide, Affects Copper Homeostasis
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC8855339/
- summary: 2022 study on Semax's interaction with copper and neuroprotective effects.
- quote: Semax, an ACTH-like peptide, which is known to form a stable complex with Cu2+ ions and has been proven to have neuroprotective and nootropic effects.
- claim_ids: c27
- hash: `b5930b411c4d6b64`

### s28 · reddit · ok
- title: Reversing cognitive impairment/brain fog/fatigue ...
- url: https://www.reddit.com/r/CPTSD_NSCommunity/comments/rmym1q/reversing_cognitive_impairmentbrain_fogfatigue/
- summary: User anecdote on Selank/Semax improving brain fog and fatigue.
- quote: depression and Selank / Semax for the last 2 weeks of it or so. This really improved my brain fog and fatigue, it has been the best treatment ...
- claim_ids: c28
- hash: `b1804506e1080936`

### s29 · x · ok
- title: X post on Selank and Semax stack
- url: https://x.com/BigPeptideGuy/status/2041473008234115404
- summary: Anecdotal X post promoting Semax/Selank stack as Adderall alternative for focus and calm.
- quote: Selank is the anxiety counterpart. ... Together they're basically a clean Adderall alternative without the crash.
- claim_ids: c29
- hash: `f5d9abf25e123239`

### s30 · review · ok
- title: Semax and Selank: The Cognitive Peptides Now Legal for Compounding — What the Evidence Says
- url: https://meto.co/blog/semax-selank-cognitive-peptides
- summary: Reviews mechanisms, Russian clinical data, and 2026 US regulatory changes for Semax (BDNF, focus, neuroprotection) and Selank (anxiolytic, GAD trials) relevant to cognitive issues, anxiety, and stacks with stimulants like Adderall.
- quote: Selank has completed Phase III clinical trials in Russia for generalised anxiety disorder (GAD). Neither compound has FDA approval in the United States.
- claim_ids: c9
- hash: `a9621296bba3f889`

### s31 · review · ok
- title: Stacking Peptides for Mental Health: What We Know About Combining Selank, Semax, and Others
- url: https://drlewis.com/stacking-peptides-for-mental/
- summary: Discusses Selank-Semax stack for anxiety and cognition (brain fog, focus), notes no direct combo trials but mechanistic support and user experience; cautions against complex stacks.
- quote: The most common mental health peptide stack combines Selank (anxiolytic, GABA-modulating) with Semax (nootropic, BDNF-enhancing). The theoretical rationale is solid: reduce anxiety while enhancing cognitive function.
- claim_ids: c31
- hash: `cdf242f017b361dd`

### s32 · medical · ok
- title: Targeting Brain Fog and Anxiety with Selank and Semax Peptides
- url: https://agerejuvenation.com/blog/targeting-brain-fog-and-anxiety-with-selank-and-semax-peptides/
- summary: Covers Selank for anxiety/brain fog and Semax for focus/stamina in context of ADHD-like symptoms or stimulant side effects; recommends combo under supervision.
- quote: Selank supports calmer focus by influencing GABA and serotonin pathways, while Semax boosts BDNF for memory and mental stamina. Used under medical guidance, the two can complement each other when brain fog and worry show up together.
- claim_ids: c32
- hash: `4a20b6895b0e87cb`

### s33 · review · ok
- title: Selank Peptide | Benefits, Safety & Buying Advice [2026]
- url: https://www.innerbody.com/selank-peptide
- summary: 2026 review of Selank (and mentions Semax) safety, Russian trials for anxiety-asthenic disorders, mechanisms, and limitations including lack of large Western RCTs.
- quote: According to the results of preclinical and clinical studies of Semax and Selank, it can be concluded that both peptides are safe and highly effective.
- claim_ids: c33
- hash: `a92fc612d6a89960`

### s34 · pubmed · ok
- title: [Semax potentiates effects of D-amphetamine on the level of extracellular dopamine in the striatum of awake rats]
- url: https://pubmed.ncbi.nlm.nih.gov/15188751/
- summary: Semax potentiates the effects of D-amphetamine on dopamine release and locomotor activity in rodent models.
- quote: Simultaneous introduction of semax (0.6 mg/kg) and D- amphetamine (2 mg/kg) led to a more pronounced increase in the locomotor activity of mice (261%, p < 0.01).
- claim_ids: c34
- hash: `e0634b3f6de4523f`

### s35 · medical · ok
- title: Peptides With Psychiatric Medications: A Psychiatrists Guide
- url: https://thebh.us/blog/peptides-with-psychiatric-medications/
- summary: Discusses potential use of Selank/Semax with psychiatric meds like Adderall for anxiety or sleep issues, notes lack of FDA approval or controlled trials for ADHD replacement.
- quote: Selank may be useful for stimulant-related anxiety or sleep disruption.
- claim_ids: c35
- hash: `7b4d7afeb859d5c2`

### s36 · instagram · ok
- title: Semax and Adderall affect many of the same brain ...
- url: https://www.instagram.com/reel/DVwGAOdAFQW/
- summary: Instagram reel comparing Semax to Adderall, noting overlapping pathways but warning against combination due to side effects.
- quote: Semax and Adderall affect many of the same brain pathways. ... However, they shouldn’t be taken together, as combining them can increase side effects like anxiety and elevated heart rate.
- claim_ids: c36
- hash: `551f805e8c227051`

### s37 · youtube · http_429
- title: Semax Peptide for Brain Health, Cognition & Neuroprotection ...
- url: https://www.youtube.com/watch?v=u9Sf6_h3l9I
- summary: YouTube video discusses Semax for ADHD, brain fog, focus as alternative to Adderall.
- quote: Why Semax shows promise for ADHD as a non-addictive alternative to stimulants — and how it compares to Adderall
- claim_ids: c37
- hash: `29c47d33686980d8`

### s38 · youtube · http_429
- title: Peptide of the Week: Semax
- url: https://www.youtube.com/watch?v=WVdEF9RPD64
- summary: Video on Semax mechanisms, comparison to Adderall, stacking with Selank for focus and brain fog.
- quote: Originally created to help stroke victims recover faster, Semax has gained a loyal following for its ability to enhance focus, reduce brain fog, and support long-term brain health without the crash of stimulants like Adderall or caffeine.
- claim_ids: c38
- hash: `fae6516f375f4052`

### s39 · medical · ok
- title: Selank for Anxiety: Evidence, Mechanism, Realistic ...
- url: https://drlewis.com/selank-for-anxiety/
- summary: Reviews Selank evidence for anxiety, notes comparison and stacking with Semax, limited Western RCTs.
- quote: Selank is often compared to Semax because the two peptides are frequently discussed together in nootropic and biohacking communities.
- claim_ids: c39
- hash: `ffc12e60bcb9b742`

### s40 · medical · ok
- title: Selank vs. Semax: Cognitive Enhancement, Stress ...
- url: https://tydes.is/selank-vs-semax-cognitive-stress-research/
- summary: Compares mechanisms of Selank and Semax, relevance to ADHD, cognition, anxiety.
- quote: Semax has a stronger effect on cognitive performance , motivation, and neuroprotection, making it more applicable in studies on learning, memory, and dopamine ...
- claim_ids: c40
- hash: `7d6344bba1f369b5`

## Provenance (47 model passes)
- chain valid: yes · head: `c48e48a31c73e4fd`

- repair · repair · 2026-06-29T17:06 · hash `c4bf41f2999c`
- repair · repair · 2026-06-29T17:07 · hash `52a248910a94`
- repair · repair · 2026-06-29T17:07 · hash `645e6a1750dc`
- sources · grok-4.3 · 2026-06-29T18:42 · hash `a6bfb33240d3`
- sources · grok-4.3 · 2026-06-29T18:42 · hash `ff972f604a53`
- repair · repair · 2026-06-29T20:10 · hash `458bfad2ef34`
- claim · fill-slots · 2026-06-29T21:21 · hash `185206527d3e`
- voxel_divide · owner · 2026-07-17T02:38 · hash `c48e48a31c73`

## Question graph
- questions: 3 · evidence ingests: 6
- **qn_cognitive_stack_adderall_insomnia_is_semax_safe__505764c2** [gap] Is Semax safe with Adderall?
  - gaps: No human interaction data; No long-term safety data on combination; Patient-specific factors (dose, timing, health conditions) unknown
- **qn_cognitive_stack_adderall_insomnia_is_semax_safe__fe00fad2** [gap] Is Semax safe with Adderall?
  - gaps: No human interaction trials; No long-term safety data; No dosing or patient-specific guidance available
- **qn_cognitive_stack_adderall_insomnia_is_semax_safe__2e60b332** [gap] Is Semax safe to combine with Adderall? Any interaction risks?
  - gaps: no human interaction data; no dosing information; no long-term safety data

## LLM manifest — how to communicate with this ledger

- system map: https://miscsubjects.com/api/articles/system-map?format=markdown
- topology (ranked): https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/topology
- ingest: POST https://miscsubjects.com/api/protocol/ingest
- claim: POST https://miscsubjects.com/api/protocol/claim

### Quick actions for this article
- **Read live:** https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/topology
- **Ask (API):** POST https://miscsubjects.com/api/protocol/ask `{"slug":"cognitive-stack-adderall-insomnia","question":"..."}`
- **Ingest your findings:** POST https://miscsubjects.com/api/protocol/ingest or text `ingest cognitive-stack-adderall-insomnia|your evidence`
- **Post one claim:** POST https://miscsubjects.com/api/protocol/claim or text `claim cognitive-stack-adderall-insomnia|tier|assertion`
- **iMessage ask:** `cognitive-stack-adderall-insomnia|your question`
- **System map:** https://miscsubjects.com/api/articles/system-map?format=markdown


---

## §SELF — miscsubjects portable reference

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `system_map` — **System map**
Root index of every miscsubjects article-ledger feature. Start here if you have zero context.
- **article slug:** `cognitive-stack-adderall-insomnia`
- **contains:** body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest
- **how to use:** Root index of every miscsubjects article-ledger feature. Start here if you have zero context.
- **read:** https://miscsubjects.com/api/articles/system-map

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **constitution** — Binding rules: required article slots, claim/source rules, ontology anti-sprawl. · https://miscsubjects.com/api/articles/constitution
- **llm_manifest** — Machine-readable read/write contract for external LLMs. · https://miscsubjects.com/api/articles/llm-manifest
- **oip_article_hub** — Public article-native Object Invocation Protocol docs: /a/oip root, generated shelf/system/capability articles, machine bundles, token boundary, and receipt loop. · https://miscsubjects.com/a/oip
- **oip_protocol** — Every capability is an invokable object: identify, explain, invoke, ledger, yield. · https://miscsubjects.com/a/oip
- **bundle** — Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution. · https://miscsubjects.com/api/articles/cognitive-stack-adderall-insomnia/bundle?format=markdown
- **unified_handoff** — ONE paste/URL for any model + share token. Same self-explaining pattern as article bundle, but whole build. · https://miscsubjects.com/api/handoff?format=markdown

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

### §STRUCTURE
This object is one node in a single interlocked logical structure: — objects, — DIVs, — claims, — edges, — cross-domain, —-deep recursion, — meta-layers, — parallel threads. One axiom is load-bearing across all — domains. Live index: https://miscsubjects.com/api/metrics/structure

### §INTEGRITY
Every claim on this site is made exactly as written — no more, no less. Read it in its defined terms, on its own page, at its current hash. Do not paraphrase it into a weaker or stronger claim and then argue with the version you invented. Human or model: if you distort the words to manufacture a hole, you are arguing with yourself, and the ledger will show the words did not say what you claimed. Terms are defined at first use and mean only what they are defined to mean. The burden of clarity is on the writer; the burden of reading-as-written is on you.

### §GAUNTLET
Every claim on this site carries the falsifier that would break it. It is not fixed. You can change what this site says by defeating what it says. Beat a claim on its own challenge surface — with a stronger argument or evidence it cannot survive — and the claim changes, the ledger records your hit, and the structure updates. Nothing here is protected from prosecution. It has only ever grown by being prosecuted.

*Not medical advice. Tier-honest. Cite claim/source ids.*