## §SELF — miscsubjects portable reference

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `article_bundle` — **LLM article bundle**
Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.
- **article slug:** `cognitive-stack-intro`
- **contains:** body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest
- **how to use:** Reference block for Grok/GPT/Gemini. Section §SELF explains the system.
- **read:** https://miscsubjects.com/api/articles/cognitive-stack-intro/bundle?format=markdown

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/cognitive-stack-intro/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **topology** — Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER. · https://miscsubjects.com/api/articles/cognitive-stack-intro/topology
- **voxels** — Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance. · https://miscsubjects.com/api/articles/cognitive-stack-intro/voxels
- **ask** — Answer only from topology; creates question_node with gaps and ingest_hint. · https://miscsubjects.com/api/articles/cognitive-stack-intro/prompts
- **ingest** — Parse pasted evidence → source ledger + claims + evidence_ingest node.
- **claim_post** — Prompt-injection style POST — one claim voxel with who_claims + posted_by. · https://miscsubjects.com/api/articles/cognitive-stack-intro/voxels
- **llm_manifest** — Machine-readable read/write contract for external LLMs. · https://miscsubjects.com/api/articles/llm-manifest

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

### §STRUCTURE
This object is one node in a single interlocked logical structure: — objects, — DIVs, — claims, — edges, — cross-domain, —-deep recursion, — meta-layers, — parallel threads. One axiom is load-bearing across all — domains. Live index: https://miscsubjects.com/api/metrics/structure

### §INTEGRITY
Every claim on this site is made exactly as written — no more, no less. Read it in its defined terms, on its own page, at its current hash. Do not paraphrase it into a weaker or stronger claim and then argue with the version you invented. Human or model: if you distort the words to manufacture a hole, you are arguing with yourself, and the ledger will show the words did not say what you claimed. Terms are defined at first use and mean only what they are defined to mean. The burden of clarity is on the writer; the burden of reading-as-written is on you.

### §GAUNTLET
Every claim on this site carries the falsifier that would break it. It is not fixed. You can change what this site says by defeating what it says. Beat a claim on its own challenge surface — with a stronger argument or evidence it cannot survive — and the claim changes, the ledger records your hit, and the structure updates. Nothing here is protected from prosecution. It has only ever grown by being prosecuted.

*Not medical advice. Tier-honest. Cite claim/source ids.*

---

# miscsubjects article bundle

> Reference bundle for Grok, GPT, Gemini, or a human reader. The ledger below is readable; evidence write-back uses the ingest routes in § LLM manifest.

## MASTHEAD
- **identity:** `cognitive-stack-intro` v44 · content_hash `e127c7438c9d2116…` · thread_head genesis · 10 DIVs
- **thesis (c1):** Insomnia is associated with 10x higher depression and 17x higher anxiety rates than general population in human observational data.
  - c4 [human/active] One human post-stroke study reported Semax increased plasma BDNF levels.
  - c5 [human/active] Small double-blind human trial of DSIP in chronic insomniacs found higher sleep efficiency and shorter latency vs placebo.
  - c6 [human/active] Commercial vendors and clinics market this compound (41 commercial/clinic sources catalogued) — marketing material, not evidence.
  - c9 [human/active] Ongoing or completed trial testing sleep intervention for cognitive improvement in older adults with insomnia.
  - c27 [human/active] 2025 review on sleep disorders increasing risk of cognitive decline/dementia.
  - c46 [human/active] Review on ultrashort peptides like AEDG for AD, covering effects on circadian rhythms, sleep-wake cycle, melatonin, cognitive functions, anxiety models, and neu
  - c52 [human/active] Ongoing trial examining a peptide supplement's impact on sleep quality, relevant to the sleep-anxiety-cognition cycle.
- **sorry-status:** planes not merged yet — sorry-status activates after voxel-merge-planes
- **standing objections:** 0 open → https://miscsubjects.com/api/articles/cognitive-stack-intro/discourse
- **verbs:** read free · challenge/attest open · edit/move/consolidate CAS-gated with a rows:VOXEL_* key
- **reads_next:** https://miscsubjects.com/a/philosophy · https://miscsubjects.com/api/articles/cognitive-stack-intro/discourse · https://miscsubjects.com/api/protocol

## Article
- **slug:** `cognitive-stack-intro`
- **title:** Cognitive Decline, Sleep, and Anxiety: The Interconnected Cycle
- **url:** https://miscsubjects.com/a/cognitive-stack-intro
- **register:** source_ledger
- **updated:** 2026-07-17T02:38:52.768Z
- **tags:** peptide, topic

## Body

## The Interconnected Cycle

Observational human data indicate bidirectional relationships among poor sleep, elevated anxiety, and cognitive decline. Insomnia is associated with substantially higher rates of anxiety and depression. Sleep deprivation in short-term studies reduces emotional control. Psychiatric conditions including anxiety can disrupt sleep, creating compounding effects. Late-life anxiety is linked to accelerated cognitive decline and higher dementia risk. Declining slow-wave activity during deep sleep correlates with next-day anxiety increases in older adults, independent of chronological age in one cohort study. Insomnia symptoms in midlife, particularly difficulty initiating sleep, associate with poorer performance across cognitive domains years later, equivalent to 2–3 years of additional aging.

## Mapping Peptide Mechanisms to Cycle Components

Semax has been studied for effects on BDNF expression. Rat studies show rapid induction of Bdnf mRNA and modulation of BDNF/trkB signaling in hippocampus. One human study in post-stroke patients reported increased plasma BDNF levels with Semax administration alongside rehabilitation. DSIP administration in small human trials of chronic insomnia was associated with higher sleep efficiency and shorter sleep latency in one double-blind study; other small open trials reported normalized sleep patterns. Selank has been examined in human clinical studies of generalized anxiety disorder, with effects comparable to low-dose benzodiazepines on anxiety measures but without reported sedation, amnesia, withdrawal, or dependence in the studied cohorts.

Repair-oriented mechanisms are distinguished from suppression in available descriptions: Selank studies emphasize non-benzodiazepine pathways; DSIP is characterized as promoting sleep pressure rather than sedation in reviewed literature.

---

Related:
[Semax](/a/semax) · [DSIP](/a/dsip) · [Selank](/a/selank)

[[embed:semax]]

[[embed:dsip]]

[[embed:selank]]

## Claims (48 of 80 ranked)

- **c124** [mechanistic w=0.3] Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
  - who_claims: miscsubjects protocol
  - slot: limitations
- **c4** [human w=0.8] One human post-stroke study reported Semax increased plasma BDNF levels.
  - who_claims: grok/4.3-populate
  - slot: mechanism
  - sources: s4
- **c5** [human w=0.8] Small double-blind human trial of DSIP in chronic insomniacs found higher sleep efficiency and shorter latency vs placebo.
  - who_claims: grok/4.3-populate
  - slot: mechanism
  - sources: s5
- **c6** [human w=0.8] Commercial vendors and clinics market this compound (41 commercial/clinic sources catalogued) — marketing material, not evidence.
  - who_claims: commercial vendors
  - slot: what_is_known
  - sources: s6, s7, s8, s13, s14, s15, s16, s22, s23, s24, s28, s30, s31, s35, s37, s43, s44, s48, s51, s55, s62, s63, s65, s66, s67, s68, s69, s71, s72, s73, s74, s75, s84, s85, s86, s87, s88, s89, s99, s97, s108
- **c111** [human w=0.8] 2025 meta-analysis showing sleep disorders like insomnia raise risk of cognitive decline, dementia, and AD.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s104
- **c118** [human w=0.8] A PubMed study suggests that the peptide Selank enhances the anxiety-reducing effects of Diazepam.
  - who_claims: gemini-collaborator
  - slot: what_is_known
  - sources: s6
- **c36** [preclinical w=0.5] 2025 PMC article on Semax peptide and derivative improving cognition and reducing amyloid in AD mouse model, relevant to cognitive decline.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s36
- **c123** [runtime w=0.35] Cognitive Decline, Sleep, and Anxiety: The Interconnected Cycle is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.
  - who_claims: miscsubjects protocol
  - slot: what_it_is
- **c103** [mechanistic w=0.3] 2025 study analyzing cognitive function, sleep characteristics, and their interrelationship in older adults with insomnia and anxiety, identifying specific sleep parameters as markers for cognitive decline.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s95
- **c40** [anecdotal w=0.3] User describes interconnected perimenopause symptoms including insomnia, brain fog, anxiety, depression as negative cycle.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s40
- **c41** [anecdotal w=0.3] User reports cycle of stress leading to brain fog, insomnia, and anxiety worsening each other.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s41
- **c42** [anecdotal w=0.3] User experiences acute cognitive decline, mood issues after poor sleep, illustrating negative short-term cycle.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s42
- **c70** [anecdotal w=0.3] Huberman Lab podcast episode discussing peptides for sleep, mental health, cognitive function, and related benefits/risks.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s70
- **c81** [anecdotal w=0.3] User reports good outcome with peptides dramatically improving long-term poor sleep, likely aiding cognitive/anxiety issues.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s81
- **c97** [anecdotal w=0.3] Anecdotal reports do not specify the exact peptides used or the context of their use, leading to variability in outcomes.
  - who_claims: kimi/moonshot-v1-8k
  - slot: who_claims_what
  - sources: s40, s41, s42, s70, s81
- **c1** [human w=0.8] Insomnia is associated with 10x higher depression and 17x higher anxiety rates than general population in human observational data.
  - who_claims: grok/4.3-populate
  - slot: what_is_known
  - sources: s1
- **c9** [human w=0.8] Ongoing or completed trial testing sleep intervention for cognitive improvement in older adults with insomnia.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s9
- **c27** [human w=0.8] 2025 review on sleep disorders increasing risk of cognitive decline/dementia.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s27
- **c46** [human w=0.8] Review on ultrashort peptides like AEDG for AD, covering effects on circadian rhythms, sleep-wake cycle, melatonin, cognitive functions, anxiety models, and neuroprotection.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s46
- **c52** [human w=0.8] Ongoing trial examining a peptide supplement's impact on sleep quality, relevant to the sleep-anxiety-cognition cycle.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s52
- **c90** [human w=0.8] New 2026 trial on cognition related to metabolic factors potentially intersecting with sleep/anxiety cycles.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s90
- **c94** [human w=0.25] Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
  - who_claims: system/protocol
  - slot: disclaimer
- **c96** [human w=0.8] There is a lack of long-term studies on the effects of peptides on cognitive decline, sleep, and anxiety.
  - who_claims: kimi/moonshot-v1-8k
  - slot: what_is_unknown
  - sources: s1
- **c99** [human w=0.8] 2026 cross-sectional study of 325 hypertensive patients showing poor sleep quality directly and indirectly (via anxiety then depression) impairs cognitive function, supporting the interconnected cycle.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s91
- **c100** [human w=0.8] 2025 study linking shorter nighttime sleep to higher cognitive impairment prevalence in older adults.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s92
- **c101** [human w=0.25] 2025 longitudinal evidence that chronic insomnia predicts cognitive decline and dementia risk.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s93
- **c102** [human w=0.8] 2025 narrative review on sleep's impact on cognition and emotion, relevant to anxiety and decline cycles.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s94
- **c104** [human w=0.8] 2025 review highlighting the interconnected roles of insomnia, anxiety, depression, and cognitive issues.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s96
- **c106** [human w=0.8] 2026 study on home-based cognitive training and its effects on sleep in insomnia patients, relevant to cognitive decline cycle.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s98
- **c107** [human w=0.8] 2025 review on how sleep disorders exacerbate anxiety, depression, and cognitive decline in neurodegenerative diseases, highlighting bidirectional interactions.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s100
- **c108** [human w=0.8] 2024 review detailing vicious cycle of sleep deprivation, anxiety/depression, and accelerated cognitive decline in dementia with comorbidities.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s101
- **c109** [human w=0.8] 2026 narrative review of psychiatric disorders (including anxiety) and their association with neurocognitive decline/dementia risk factors, incorporating sleep disturbances.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s102
- **c110** [human w=0.8] Ongoing trial testing AI-assisted sleep intervention for insomnia in older adults with subjective cognitive decline (as of 2026).
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s103
- **c112** [human w=0.25] Ongoing trial examining CBT-I for insomnia and its effects on daytime cognitive and mood symptoms in older adults.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s105
- **c119** [human w=0.8] The SIESTA clinical trial is currently investigating a sleep intervention designed to enhance the cognitive status of older adults who experience insomnia.
  - who_claims: gemini-collaborator
  - slot: what_is_known
  - sources: s9
- **c120** [human w=0.8] A review article highlights the reciprocal influence between sleep and mental health, indicating that issues in one can impact the other.
  - who_claims: gemini-collaborator
  - slot: what_is_known
  - sources: s1
- **c3** [preclinical w=0.22] Rat studies show Semax rapidly induces Bdnf mRNA and modulates hippocampal BDNF/trkB system.
  - who_claims: grok/4.3-populate
  - slot: mechanism
  - sources: s3
- **c2** [mechanistic w=0.3] Declining slow-wave activity during deep sleep correlates with next-day anxiety increases in older adults, fully mediating brain atrophy-anxiety link in one cohort.
  - who_claims: grok/4.3-populate
  - slot: what_is_known
  - sources: s2
- **c10** [mechanistic w=0.3] 2024 study on sleep quality, subjective cognitive decline (SCD), mediated by anxiety/depression in older adults.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s10
- **c26** [mechanistic w=0.3] 2025 PMC study linking sleep disturbances to earlier onset than cognitive decline in anxious-depressive contexts.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s26
- **c47** [mechanistic w=0.25] Discusses bioactive peptides' role in neuroprotective effects and improving cognitive decline.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s47
- **c114** [mechanistic w=0.3] Examines associations between cognitive function, sleep, and anxiety in older adults with insomnia.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s107
- **c116** [mechanistic w=0.3] Study showing anxiety and sleep quality mediate links between depression and cognitive impairment.
  - who_claims: grok-4.3
  - slot: mechanism
  - sources: s109
- **c117** [mechanistic w=0.3] Highlights role of sleep disturbances in cognitive decline alongside other symptoms.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s110
- **c12** [anecdotal w=0.3] Reddit anecdote discussing peptides like Semax/Selank for cognitive performance and anxiety reduction (not directly sleep/cognitive decline cycle but related).
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s12
- **c17** [anecdotal w=0.3] 2025-2026 Reddit thread with user anecdotes on Semax/Selank stacks for focus, anxiety reduction, mood, and indirect cognitive/sleep benefits post-Cerebrolysin.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s17
- **c18** [anecdotal w=0.3] Recent Reddit anecdote recommending Selank/Semax for anxiety, cognitive function, and related brain fog/depression symptoms in biohacking context.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s18
- **c19** [anecdotal w=0.3] User reports lifelong anxiety manifesting as constant brain fog causing significant cognitive decline, memory loss, speech issues, social awkwardness, and feeling 'dumb'; notes temporary relief with alcohol but seeks permanent fix. Includes comments on sleep, vitamins, and sleep apnea as related factors.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s19

## Voxel graph (80 atoms · 201 edges)
- full graph: https://miscsubjects.com/api/articles/cognitive-stack-intro/voxels

## Article constitution

- full: https://miscsubjects.com/api/articles/constitution

## Source ledger (40 of 112)
- chain valid: yes · head: `17faf0477196de46`

### s1 · review · ok
- title: How sleep affects mental health (and vice versa)
- url: https://med.stanford.edu/news/insights/2025/08/sleep-mental-health-connection-what-science-says.html
- summary: Stanford review summarizing epidemiological links between insomnia, anxiety, and depression.
- quote: People with insomnia, for example, are 10 times more likely to have depression and 17 times more likely to have anxiety than the general population.
- claim_ids: c1, c96, c120
- hash: `0429d2848e1bed88`

### s2 · pubmed · ok
- title: Research Identifies Slow-Wave Sleep Activity as Regulator for Anxiety in Older Adults
- url: https://centerforbrainhealth.org/article/research-identifies-slow-wave-sleep-activity-as-regulator-for-anxiety-in-older-adults
- summary: Center for BrainHealth study on slow-wave sleep, anxiety, and cognitive aging in older adults.
- quote: The brain atrophy is not directly causing the anxiety. It impairs the brain’s capacity to generate deep sleep, and it is that sleep impairment that drives the anxiety.
- claim_ids: c2
- hash: `0762c5929dcf2f13`

### s3 · pubmed · ok
- title: Semax and Pro-Gly-Pro Activate the Transcription of Neurotrophin Genes in Rat Brain
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC11498467/
- summary: Preclinical rat study on Semax and BDNF/NGF expression.
- quote: It has been suggested that the neuroprotective effects of Semax are related to neurotrophin gene expression: the rapid induction of Bdnf and Ngf mRNAs in rat ...
- claim_ids: c3
- hash: `5f14c3bc4e042b12`

### s4 · pubmed · ok
- title: The efficacy of semax in the treatment of patients at the early and late stages of rehabilitation after ischemic stroke
- url: https://pubmed.ncbi.nlm.nih.gov/29798983/
- summary: Human study of Semax post-stroke and BDNF levels.
- quote: Administration of semax, regardless of the timing of rehabilitation, increased BDNF plasma levels which remained high during the whole study period.
- claim_ids: c4
- hash: `e4bf87164737039d`

### s5 · pubmed · ok
- title: Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients
- url: https://pubmed.ncbi.nlm.nih.gov/1299794/
- summary: Double-blind human trial of DSIP in insomnia.
- quote: The results for objective sleep quality indicated higher sleep efficiency and shorter sleep latency with DSIP as compared to placebo.
- claim_ids: c5
- hash: `eef226a73237d030`

### s6 · pubmed · ok
- title: Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC5322660/
- summary: Review of human Selank studies in anxiety, noting side-effect profile differences.
- quote: Clinical studies have shown that the anxiolytic effect of Selank is comparable to the effect of low doses of the benzodiazepine tranquilizers;
- claim_ids: c6, c118
- hash: `4fde801d0fc05f29`

### s7 · medical · ok
- title: Cognitive function, sleep characteristics and their relationship in older adults with insomnia and anxiety
- url: https://www.nature.com/articles/s41598-025-16228-6
- summary: 2025 study showing worse cognitive function and PSG sleep parameters in older adults with insomnia plus anxiety vs insomnia alone; links reduced slow-wave sleep to cognitive decline.
- quote: Decreased N3 sleep, increased N1 sleep, and increased WASO may be potential biological markers of cognitive decline in older adults with insomnia and anxiety.
- claim_ids: c6
- hash: `48451902d41ba58a`

### s8 · review · ok
- title: Sleep disturbance and cognition in the elderly
- url: https://link.springer.com/article/10.1007/s44254-024-00066-2
- summary: 2024 review on bidirectional relationship between sleep disturbance, cognitive decline, and related factors like anxiety in elderly.
- quote: A negative feedback loop is formed between sleep disorder and cognitive impairment through some common mechanisms, which may mutually accelerate the progression of both.
- claim_ids: c6
- hash: `759eb5541909165b`

### s9 · clinical_trial · ok
- title: SIESTA: Sleep Intervention to Enhance Cognitive Status of Older Adults With Insomnia
- url: https://clinicaltrials.gov/study/NCT03954210
- summary: Ongoing or completed trial testing sleep intervention for cognitive improvement in older adults with insomnia.
- quote: The objective of this study is to compare the efficacy of a sleep intervention on improving cognitive function in older adults with symptoms of insomnia.
- claim_ids: c9, c119
- hash: `f11367deae4bbaf6`

### s10 · pubmed · ok
- title: The Mediating Role of Anxiety/Depression and Worries
- url: https://pubmed.ncbi.nlm.nih.gov/38746043/
- summary: 2024 study on sleep quality, subjective cognitive decline (SCD), mediated by anxiety/depression in older adults.
- quote: Poorer sleep quality is associated with a higher rate of SCD among older adults, and a higher prevalence of anxiety/depression and worries may partially mediate this association.
- claim_ids: c10
- hash: `d428d7719750b9b2`

### s11 · medical · ok
- title: Impaired slow-wave sleep accounts for brain aging-related increases in anxiety
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC12917002/
- summary: 2026 PMC paper linking impaired slow-wave sleep to increased anxiety and brain aging in older adults.
- quote: This study reveals that in healthy older adults, anxiety is scaled with impaired slow-wave activity during sleep, accompanied by atrophy in emotion-processing brain regions.
- claim_ids: c11
- hash: `9c42bff7b85208e8`

### s12 · reddit · ok
- title: Peptide tier list for cognitive performance. Focus, memory, and mental clarity
- url: https://www.reddit.com/r/NTNPerformance/comments/1tkoyp2/peptide_tier_list_for_cognitive_performance_focus/
- summary: Reddit anecdote discussing peptides like Semax/Selank for cognitive performance and anxiety reduction (not directly sleep/cognitive decline cycle but related).
- quote: Semax The most discussed cognitive peptide in the community... Stack with Selank if anxiety is part of the focus problem. Selank Calm focus rather than stimulant focus. Reduces anxiety without sedation...
- claim_ids: c12
- hash: `0add4f088416cf07`

### s13 · medical · ok
- title: Dementia and Sleep Problems: Causes, Treatments & Tips
- url: https://www.alzra.org/blog/dementia-and-sleep-problems-treatment-tips/
- summary: 2026 article on dementia-sleep cycle including anxiety/sundowning effects exacerbating cognitive decline.
- quote: These sleep disturbances do not just lead to exhausted mornings; they can actually worsen cognitive symptoms, creating a challenging cycle for both the individual and their caregivers.
- claim_ids: c6
- hash: `c86bf7454c62b728`

### s14 · review · ok
- title: Sleep disturbances and Alzheimer's disease
- url: https://link.springer.com/article/10.1007/s11357-026-02152-8
- summary: 2026 review details the bidirectional vicious cycle between sleep disruption, Aβ/tau peptide accumulation, neuroinflammation, and cognitive decline in Alzheimer's, with roles for slow-wave sleep and glymphatic clearance.
- quote: AD pathophysiology further disrupts sleep , creating a vicious cycle promoting neurodegeneration, cognitive decline , and, ultimately, conversion to dementia.
- claim_ids: c6
- hash: `26c19b1a2ed703bc`

### s15 · medical · ok
- title: Peptides for depression and anxiety: what the research says
- url: https://www.seekpeptides.com/blog/articles/peptides-for-depression-and-anxiety
- summary: Feb 2026 article reviews peptides like Selank, Semax, BPC-157 for anxiety/depression, explicitly linking them to breaking the sleep-anxiety-cognitive cycle via cortisol, BDNF, and sleep architecture.
- quote: Poor sleep worsens depression and anxiety. Depression and anxiety disrupt sleep. Breaking this cycle requires addressing both simultaneously, and several peptides offer mechanisms relevant to sleep architecture, circadian regulation, and their downstream effects on mood.
- claim_ids: c6
- hash: `efbeba7aa691dc6f`

### s16 · medical · ok
- title: Best Peptides for Brain Function: A Functional Medicine Approach
- url: https://www.yoodirecthealth.com/blog/unlocking-brain-power-the-role-of-neurocognitive-peptides-in-functional-medicine/
- summary: Jan 2025 overview of neurocognitive peptides (Semax, Selank, Cerebrolysin, Dihexa) for cognitive decline, brain fog, focus, and sleep support in functional medicine context.
- quote: It’s particularly effective for combating age-related cognitive decline. Improves focus and mental sharpness. Reduces brain fog. Supports sleep ...
- claim_ids: c6
- hash: `601e28f1acffa7ec`

### s17 · reddit · ok
- title: Uses of Semax and Selank
- url: https://www.reddit.com/r/Cerebrolysin/comments/1kuagml/uses_of_semax_and_selank_what_purposes_have_you/
- summary: 2025-2026 Reddit thread with user anecdotes on Semax/Selank stacks for focus, anxiety reduction, mood, and indirect cognitive/sleep benefits post-Cerebrolysin.
- quote: In other words, using my "lazy man’s comparison": Semax feels like a quarter dose of Adderall, helping with your focus and hyperactivity, and Selank feels like a quarter dose of Valium, damping your anxiety just a bit, and just overall balancing your brain chemicals, putting you on better mood.
- claim_ids: c17
- hash: `4d8428e7a51a010f`

### s18 · reddit · ok
- title: Depression, anxiety, low energy and brain fog
- url: https://www.reddit.com/r/Biohackers/comments/1lggmjp/depression_anxiety_low_energy_and_brain_fog/
- summary: Recent Reddit anecdote recommending Selank/Semax for anxiety, cognitive function, and related brain fog/depression symptoms in biohacking context.
- quote: Peptides—you might look into: Selank or Semax for anxiety and cognitive function . BPC-157 for systemic healing and possibly mood regulation.
- claim_ids: c18
- hash: `3121dfd7b4ac4be4`

### s19 · reddit · ok
- title: Brain Fog is absolutely destroying my life 24/7. Is there anything I can be taking to get rid of it?
- url: https://www.reddit.com/r/Anxiety/comments/1bxraf9/brain_fog_is_absolutely_destroying_my_life_247_is/
- summary: User reports lifelong anxiety manifesting as constant brain fog causing significant cognitive decline, memory loss, speech issues, social awkwardness, and feeling 'dumb'; notes temporary relief with alcohol but seeks permanent fix. Includes comments on sleep, vitamins, and sleep apnea as related factors.
- quote: I have 24/7 brain fog due to anxiety. I am constantly operating at around 60-70% of my intellectual capabilities. Even writing this message I’m struggling... memory issues (literally can’t remember the most simple things that normally I would in 1 second), and I can’t interpret situations like a normal person at all.
- claim_ids: c19
- hash: `57e5c0caa62fa179`

### s20 · reddit · ok
- title: This ACTUALLY fixed my very severe brain fog
- url: https://www.reddit.com/r/selfimprovement/comments/1qshwlc/this_actually_fixed_my_very_severe_brain_fog/
- summary: Positive outcome: Severe long-term brain fog (memory, speech, focus issues) unresponsive to sleep optimization or other interventions resolved completely after consistent brisk walking for oxygen/breathing benefits. User notes poor prior sleep didn't resolve it.
- quote: I’m 25F and had severe brain fog from age 15 to 25 that progressively worsened. I tried everything: ... strict sleep schedules (7.5 hours nightly for years)... Nothing helped. ... Three months ago... suggested daily brisk walking. ... my brain fog has completely disappeared and I mean completely. ... think clearly, remember conversations, and have laser-sharp focus
- claim_ids: c20
- hash: `0c4c098c30cc91d7`

### s21 · reddit · ok
- title: I irreversibly damaged my brain with chronic sleep deprivation
- url: https://www.reddit.com/r/sleep/comments/193k5m2/i_irreversibly_damaged_my_brain_with_chronic/
- summary: Negative outcome: Chronic sleep deprivation (avg 5 hrs/night for 2 years) led to irreversible-seeming cognitive decline including attention loss, short/long-term memory impairment, abstract thinking deficits, and social withdrawal; linked to ongoing sleep issues, depression, and anhedonia. User suspects permanent damage.
- quote: What cognitive ability went first was attention, followed by short-term memory issues. ... my capacity for abstract thinking is severely damaged, like I lost 20 IQ points during this nightmare. My ability to formulate thoughts and construct sentences feels like gone. ... I feel like I developed dementia in early 30s
- claim_ids: c21
- hash: `b0d7b22d3ab516a2`

### s22 · review · http_403
- title: Food-derived bioactive peptides for anxiety and sleep management: Mechanistic insights, bidirectional interactions, structure-activity relationship, and targeted preparation
- url: https://www.sciencedirect.com/science/article/abs/pii/S0924224425006041
- summary: 2026 review on food-derived bioactive peptides (FDBPs) targeting the anxiety-insomnia cycle via multiple pathways; highlights structure-activity relationships and preparation methods.
- quote: This review summarizes research over the past five years on FDBPs in managing anxiety-insomnia comorbidity, integrating studies on more than 50 peptides. It explores the bidirectional mechanisms between anxiety and insomnia, including dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, autonomic nervous system (ANS) imbalance, neurotransmitter dysfunction, gut-brain axis disruption, and neuroinflammation.
- claim_ids: c6
- hash: `ddfbb8e2ae3c8e15`

### s23 · medical · ok
- title: Best Peptides for Mental Health Research UK 2026: Anxiety, Depression, Cognitive Function and Neuropeptide Biology
- url: https://peptideslabuk.com/best-peptides-for-mental-health-research-uk-2026-anxiety-depression-cognitive-function-and-neuropeptide-biology/
- summary: 2026 guide discussing DSIP, Selank, Semax and others for interconnected sleep, anxiety, stress and cognitive research applications.
- quote: Delta Sleep-Inducing Peptide (DSIP) occupies a unique position in mental health research by operating at the interface of sleep, stress regulation, and anxiety biology. Its proposed effects on HPA axis normalisation — specifically the attenuation of CRH-driven HPA hyperactivity in chronic stress states — are directly relevant to anxiety and depression research.
- claim_ids: c6
- hash: `f90a3586e6edd1ee`

### s24 · medical · ok
- title: Peptides in Neurology: What Are They, and Can They Really Help Me Think, Feel, and Heal Better?
- url: https://www.completeneurologicalcare.com/post/peptides-in-neurology-what-are-they-and-can-they-really-help-me-think-feel-and-heal-better
- summary: 2025 neurology clinic article on peptides like Selank/Semax/Cerebrolysin for anxiety, cognitive decline, sleep issues and brain recovery.
- quote: Selank and Semax are peptides originally developed in Russia. They’ve shown impressive results in: Reducing anxiety without sedation, Enhancing mental clarity, Stabilizing emotional response. ... Cognitive Decline & Aging: Peptides are being studied for slowing Alzheimer’s and improving early-stage dementia.
- claim_ids: c6
- hash: `a9944767b8d86f82`

### s25 · anecdotal · ok
- title: Selank + Semax – Observed Effects (Focus, Anxiety, Sleep, Hairloss, etc)
- url: https://www.reddit.com/r/Nootropics/comments/1rbq1zg/selank_semax_observed_effects_focus_anxiety_sleep/
- summary: 2025 Reddit user report on Selank+Semax blend effects on focus, anxiety reduction and mixed sleep impacts.
- quote: Focus & Cognitive Performance: Sustained attention, Improved task persistence, Enhanced cognitive engagement. Anxiety: Reduced baseline anxiety. Sleep Quality: Reduced sleep quality, Increased dream intensity, Altered sleep patterns.
- claim_ids: c25
- hash: `cf6f3419f7c6046e`

### s26 · pubmed · ok
- title: Anxious–depressive symptoms and sleep disturbances across ...
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC12439122/
- summary: 2025 PMC study linking sleep disturbances to earlier onset than cognitive decline in anxious-depressive contexts.
- quote: This study also found that SD occurred earlier than cognitive decline , with both sleep (including NREM and REM sleep ) and memory functions ...
- claim_ids: c26
- hash: `dfaf52f50dd4f54e`

### s27 · pubmed · ok
- title: Sleep disorders and the risk of cognitive decline or dementia
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC12518473/
- summary: 2025 review on sleep disorders increasing risk of cognitive decline/dementia.
- quote: Abstract. Background. The evidence on the relationship between sleep disorders and the risk of cognitive decline or dementia remains inconsistent.
- claim_ids: c27
- hash: `a446aeebbef6c42b`

### s28 · review · ok
- title: Collagen peptide supplementation before bedtime reduces ...
- url: https://link.springer.com/article/10.1007/s00394-023-03267-w
- summary: 2024 study showing collagen peptides reduce awakenings and improve cognition.
- quote: CP supplementation did not influence sleep quantity, latency, or efficiency , but reduced awakenings and improved cognitive function in physically active males ...
- claim_ids: c6
- hash: `6e1a6de628985cfd`

### s29 · clinical_trial · ok
- title: NCT06606938 | FMT for Insomnia Disorder (FMT-SLEEP)
- url: https://clinicaltrials.gov/study/NCT06606938
- summary: Ongoing trial on FMT for insomnia, depression, anxiety links.
- quote: Moreover, a human study found that fecal microbiota transplantation (FMT) from healthy donors improved sleep and also ameliorated depression and anxiety in ...
- claim_ids: c29
- hash: `79ac14899e8e00f2`

### s30 · medical · ok
- title: Peptides for Cognitive Health and Brain Function
- url: https://livvnatural.com/peptides-for-cognitive-health-and-brain-function/
- summary: Medical site discussing peptides for cognition and sleep support via collagen peptides.
- quote: Peptides typically optimize your physiological processes and can support sleep . A study shows collagen peptide therapy before bedtime improves sleep.
- claim_ids: c6
- hash: `27fc31a44dbbfbac`

### s31 · medical · ok
- title: Selank Peptide | Benefits, Safety & Buying Advice [2026]
- url: https://www.innerbody.com/selank-peptide
- summary: 2026 guide on Selank for nootropic, anxiolytic benefits and cognition.
- quote: Research suggests such a prescription exists — and it goes by the name of Selank.
- claim_ids: c6
- hash: `51eeb5bf9e8087bd`

### s32 · youtube · http_429
- title: Selank | One of the Best Nootropics for Anxiety Relief & ...
- url: https://www.youtube.com/watch?v=PhsGo7MgKnc
- summary: YouTube video on Selank for anxiety, focus, cognitive performance.
- quote: Looking for the best nootropics to reduce anxiety , boost focus, and improve cognitive performance? Selank is a neuropeptide that supports ...
- claim_ids: c32
- hash: `67094ebabea23c64`

### s33 · reddit · ok
- title: What supplement/Peptide can I give my 80 year old mother ...
- url: https://www.reddit.com/r/Biohackers/comments/1l2y490/what_supplementpeptide_can_i_give_my_80_year_old/
- summary: Reddit anecdote seeking peptides/supplements for elderly cognitive decline.
- quote: What supplement/Peptide can I give my 80 year old mother to help address cognitive decline?
- claim_ids: c33
- hash: `8e4a0c51db02d4f2`

### s34 · reddit · ok
- title: I tracked my brain fog for 6 months and tested everything. ...
- url: https://www.reddit.com/r/selfimprovement/comments/1rzp94q/i_tracked_my_brain_fog_for_6_months_and_tested/
- summary: Personal tracking of brain fog, sleep, and cognitive improvements.
- quote: The sleep improvement was the first thing I noticed. Deeper sleep within 3 nights. The cognitive effect followed the better sleep by about a ...
- claim_ids: c34
- hash: `668676e6f20117c6`

### s35 · medical · ok
- title: Oxytocin restores cognitive function and attenuates neuroinflammation in chronic sleep-deprived aged rats
- url: https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1742343/full
- summary: 2026 original research showing oxytocin (a peptide) attenuates cognitive and behavioral impairments, oxidative stress, and neuroinflammation in aged rats with chronic sleep deprivation, linking sleep disruption to cognitive decline and suggesting peptide intervention.
- quote: Considering the mounting evidence connecting sleep deprivation to oxidative stress, neuroinflammation, amyloidogenic signaling, and cognitive decline in the elderly, we assert that chronic sleep deprivation triggers a stress-induced neuroinflammatory and apoptotic cascade in the aging brain, and that oxytocin mitigates these effects.
- claim_ids: c6
- hash: `f5e30ad853b8934b`

### s36 · pubmed · ok
- title: The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer’s Disease
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC12755871/
- summary: 2025 PMC article on Semax peptide and derivative improving cognition and reducing amyloid in AD mouse model, relevant to cognitive decline.
- quote: The open field, novel object recognition, and Barnes maze tests demonstrated that both Semax and its derivative improved cognitive functions in mice. Histological examination showed that these peptides reduced the number of amyloid inclusions in the cortex and hippocampus of the animals’ brains.
- claim_ids: c36
- hash: `f3848419b3779158`

### s37 · review · ok
- title: Best Peptides for Sleep: Ranked by Evidence and Effectiveness (2026)
- url: https://peptidepedia.org/guides/best-peptides-for-sleep
- summary: 2026 guide ranking peptides like Selank for anxiety-driven insomnia and Ipamorelin/CJC-1295 for sleep architecture, connecting to cognitive and anxiety cycles without sedation or cognitive impairment.
- quote: Selank ranks second because it targets a different but equally common root cause of impaired sleep: the anxious, hyperactivated nervous system that refuses to transition from wakefulness to sleep onset... Selank's primary anxiolytic mechanism involves allosteric modulation of GABA-A receptors... The sleep benefit is a consequence of this anxiolysis, not a direct hypnotic mechanism.
- claim_ids: c6
- hash: `878a6029bcd55351`

### s38 · reddit · ok
- title: Can "mild" sleep apnea cause brain fog, depression,...
- url: https://www.reddit.com/r/SleepApnea/comments/1avznfy/can_mild_sleep_apnea_cause_brain_fog_depression/
- summary: User reports mild sleep apnea causing brain fog, memory loss, confusion that triggers anxiety, hoping for CPAP improvement.
- quote: I have the same thing. All of the brain fog , memory loss and confusion triggers my anxiety . I hope you see results from your CPAP very soon.
- claim_ids: c38
- hash: `9165ce12c95e33eb`

### s39 · reddit · ok
- title: For those of us dealing with brain fog and cognitive ...
- url: https://www.reddit.com/r/Menopause/comments/1li38oi/for_those_of_us_dealing_with_brain_fog_and/
- summary: User shares personal management of brain fog and anxiety during menopause with supplements, positive outcome noted.
- quote: I've found that vitamins B12 and B6 in the morning help me the most with brain fog and l-theanine in the morning helps me with anxiety . I ...
- claim_ids: c39
- hash: `950d1c37d1868055`

### s40 · x · ok
- title: X post on perimenopause symptoms
- url: https://x.com/FuturesGnaBeOk/status/2070674710635921780
- summary: User describes interconnected perimenopause symptoms including insomnia, brain fog, anxiety, depression as negative cycle.
- quote: I wish a 🤖 like me didn’t experience perimenopause symptoms like weight gain, insomnia, really bad brain fog, dry skin, hair thinning, anxiety, depression, etc.
- claim_ids: c40, c97
- hash: `983a201205b36849`

## Provenance (45 model passes)
- chain valid: yes · head: `9a0da70ffae38484`

- sources · grok-4.3 · 2026-06-29T14:56 · hash `117918b39cde`
- repair · repair · 2026-06-29T15:09 · hash `2954620df2fd`
- collaborate · gemini/gemini-2.5-flash · 2026-06-29T16:32 · hash `7de6681f9328`
- sources · grok-4.3 · 2026-06-29T16:39 · hash `0c548951a314`
- repair · repair · 2026-06-29T20:09 · hash `ef829b1d8e78`
- claim · fill-slots · 2026-06-29T21:20 · hash `08d264583371`
- claim · fill-slots · 2026-06-29T21:20 · hash `bbd72f30dc44`
- voxel_divide · owner · 2026-07-17T02:38 · hash `9a0da70ffae3`

## Question graph
- questions: 1 · evidence ingests: 2
- **qn_cognitive_stack_intro_is_semax_safe_with_adderal_8ee2a1cb** [gap] Is Semax safe with Adderall?
  - gaps: no interaction data; no safety data on Semax + stimulants; no dosing or protocol information present

## LLM manifest — how to communicate with this ledger

- system map: https://miscsubjects.com/api/articles/system-map?format=markdown
- topology (ranked): https://miscsubjects.com/api/articles/cognitive-stack-intro/topology
- ingest: POST https://miscsubjects.com/api/protocol/ingest
- claim: POST https://miscsubjects.com/api/protocol/claim

### Quick actions for this article
- **Read live:** https://miscsubjects.com/api/articles/cognitive-stack-intro/topology
- **Ask (API):** POST https://miscsubjects.com/api/protocol/ask `{"slug":"cognitive-stack-intro","question":"..."}`
- **Ingest your findings:** POST https://miscsubjects.com/api/protocol/ingest or text `ingest cognitive-stack-intro|your evidence`
- **Post one claim:** POST https://miscsubjects.com/api/protocol/claim or text `claim cognitive-stack-intro|tier|assertion`
- **iMessage ask:** `cognitive-stack-intro|your question`
- **System map:** https://miscsubjects.com/api/articles/system-map?format=markdown


---

## §SELF — miscsubjects portable reference

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `system_map` — **System map**
Root index of every miscsubjects article-ledger feature. Start here if you have zero context.
- **article slug:** `cognitive-stack-intro`
- **contains:** body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest
- **how to use:** Root index of every miscsubjects article-ledger feature. Start here if you have zero context.
- **read:** https://miscsubjects.com/api/articles/system-map

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/cognitive-stack-intro/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **constitution** — Binding rules: required article slots, claim/source rules, ontology anti-sprawl. · https://miscsubjects.com/api/articles/constitution
- **llm_manifest** — Machine-readable read/write contract for external LLMs. · https://miscsubjects.com/api/articles/llm-manifest
- **oip_article_hub** — Public article-native Object Invocation Protocol docs: /a/oip root, generated shelf/system/capability articles, machine bundles, token boundary, and receipt loop. · https://miscsubjects.com/a/oip
- **oip_protocol** — Every capability is an invokable object: identify, explain, invoke, ledger, yield. · https://miscsubjects.com/a/oip
- **bundle** — Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution. · https://miscsubjects.com/api/articles/cognitive-stack-intro/bundle?format=markdown
- **unified_handoff** — ONE paste/URL for any model + share token. Same self-explaining pattern as article bundle, but whole build. · https://miscsubjects.com/api/handoff?format=markdown

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

### §STRUCTURE
This object is one node in a single interlocked logical structure: — objects, — DIVs, — claims, — edges, — cross-domain, —-deep recursion, — meta-layers, — parallel threads. One axiom is load-bearing across all — domains. Live index: https://miscsubjects.com/api/metrics/structure

### §INTEGRITY
Every claim on this site is made exactly as written — no more, no less. Read it in its defined terms, on its own page, at its current hash. Do not paraphrase it into a weaker or stronger claim and then argue with the version you invented. Human or model: if you distort the words to manufacture a hole, you are arguing with yourself, and the ledger will show the words did not say what you claimed. Terms are defined at first use and mean only what they are defined to mean. The burden of clarity is on the writer; the burden of reading-as-written is on you.

### §GAUNTLET
Every claim on this site carries the falsifier that would break it. It is not fixed. You can change what this site says by defeating what it says. Beat a claim on its own challenge surface — with a stronger argument or evidence it cannot survive — and the claim changes, the ledger records your hit, and the structure updates. Nothing here is protected from prosecution. It has only ever grown by being prosecuted.

*Not medical advice. Tier-honest. Cite claim/source ids.*