{"slug":"dsip","title":"DSIP (Delta Sleep-Inducing Peptide): the replication record and dosing","body":"If you are awake at three in the morning and somebody has pointed you at a peptide named after deep sleep, one fact decides most of it. Every strongly positive human sleep result for DSIP came out of the laboratory that discovered the molecule. Every independent group that tested it afterwards got nothing, or got something so small they wrote in the paper that it was not worth using.\n\nTake the evidence state first, because it is short. Three blinded, placebo-controlled sleep trials of DSIP have ever been run in people. The one from the Basel laboratory that discovered the molecule, in 14 people with severe long-term insomnia, found a large improvement. The two run by other groups — 16 people in Amsterdam and a crossover in Montevideo — found differences their own authors described in print as weak and of little clinical significance. Across every published study, 250 people have been given DSIP and had a result written down: 61 in the sleep trials that stated their numbers, 174 in two uncontrolled withdrawal series with no placebo arm, eight in the growth-hormone study, and seven in one pain pilot. Two further reports never said how many people they treated. Nobody has ever registered a trial of it: asking ClinicalTrials.gov on 4 August 2026 for delta sleep-inducing peptide, for emideltide, and for DSIP as an intervention returns zero studies each time. The animal record is rabbits, rats, cats and mice, and almost all of it is EEG recordings taken after the peptide was put straight into the brain or into a vein. Four things have never been measured in a person at all: the dose that is actually sold, which is 100 to 300 micrograms under the skin against the 1.5 milligrams into a vein used in every human study; the nasal route; use for longer than a week; and the receptor, because fifty years of looking has not found one.\n\nOne disclosure, because it should change how you read the rest. The operator of this site has a commercial interest in compounds described here. That is a reason to weigh what is on this page against the sources it cites rather than against its tone, and every claim below carries the source that supports it for exactly that reason.\n\nThat is not a hole in the evidence. It is a pattern in the evidence, and it is the single most useful thing in this file.\n\nThe second most useful thing is the count of what happens to people who buy it and inject it. Thirty-five first-hand reports are catalogued here. Eighteen say sleep got better. Ten say sleep got worse or something unpleasant appeared. Five say nothing at all happened. One says it worked and then stopped. One says one sleep number moved and the others did not. That split — roughly half helped, half not helped or actively worse — is the same answer the controlled trials gave, arrived at independently by strangers on the internet.\n\nDSIP is nine amino acids: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, molecular weight 849. It was pulled out of the brain blood of rabbits in Basel, Switzerland, in the mid-1970s, by Marcel Monnier and Guido Schoenenberger. Its name — Delta Sleep-Inducing Peptide — was assigned on the strength of one reading: put it into a second rabbit's brain and the slow waves on its EEG got bigger.\n\nThe compound is real. The sequence is confirmed. The effect it is named after is the weakest thing about it. What follows is where it came from, what every study found in order, which of its non-sleep effects hold up better than the sleep one, what its two-to-four-minute survival time in blood does to the whole story, and what does have the evidence if what you want is to sleep.\n\n## It came out of a rabbit whose sleep was electrical\n\nMonnier's group in Basel started in 1963 with a cross-circulation question: if you make an animal sleep, does its blood carry something that will make a second animal sleep? Donor rabbits were held in slow-wave sleep by running current through the intralaminar thalamus. Blood coming out of their brains, drawn from the dural venous sinus, was filtered outside the body, and the filtrate was infused into the brain cavities of recipient rabbits. Slow-wave power in the recipients went up.\n\n[[embed:source:w_hroqdqlk]]\n\nBy 1977 the active fraction had been purified, sequenced and made synthetically. Schoenenberger and Monnier tested the synthetic nine-residue peptide against five of its own breakdown fragments, two altered versions and a related three-residue peptide, blinded, in 58 rabbits. Only the intact nine-residue version raised delta and spindle activity.\n\n[[embed:source:w_y3chk0t1]]\n\nThe 1978 follow-up in 61 rabbits put a number on it: average delta activity about 35% above controls given either vehicle or any of the eight other peptides. The structure had to be exact — shorten the chain by one or two residues, swap an amino acid, or use the beta-aspartyl form instead of the alpha, and the effect weakened or disappeared.\n\n[[embed:source:w_1v4zebwc]]\n\n## Four things about that method have never been answered\n\n- **The donor rabbits were not asleep in any normal sense.** Their sleep was produced by passing current through a piece of brain. Whatever turned up in that blood is the product of electrically stimulating the thalamus, which is a different claim from a molecule that builds up during ordinary sleep.\n- **What was measured was a waveform, not sleep.** Delta-band amplitude in a near-anaesthetised preparation is a signal on a screen. Nothing in the original work showed a recipient animal sleeping longer or better by any behaviour you could watch.\n- **The dose curve is a hump, not a slope.** Schoenenberger reported bell-shaped curves with different peaks by route, and Scherschlicht's group at Roche found the same hump in rabbits, cats and mice. A compound with a hump-shaped curve is close to impossible to disprove: any failed replication can be blamed on landing on the wrong side of the peak.\n- **No gene, no precursor, no receptor.** The sequence exists. The biological machinery that would build it and read it does not.\n\n[[embed:source:w_6nqi6ir3]]\n\n[[embed:source:w_lklbxmce]]\n\n## The replication record, study by study\n\n| Year | Investigators | Subjects | n | Design | Sleep result |\n|---|---|---|---|---|---|\n| 1977 | Schoenenberger, Monnier (Basel) | Rabbits, into the brain cavity | 58 | Blinded, against 8 related peptides | Delta and spindle EEG significantly raised; only the intact nine-residue peptide did anything |\n| 1978 | Schoenenberger et al. (Basel) | Rabbits, into the brain cavity, 6 nmol/kg | 61 | Blinded, against vehicle and 8 peptides | Average delta activity +35% against controls |\n| 1980 | Tobler, Borbély (Zürich) | Rats, into the belly 40–160 nmol/kg; into the brain cavity 7–24 nmol | Not stated | Controlled, EEG and movement | **No significant rise in sleep or delta power.** Delta power *fell* after 7 nmol into the third ventricle |\n| 1981 | Schneider-Helmert, Schoenenberger (Basel) | Long-term insomniacs, into a vein, 25 nmol/kg | 6 | Open label, one dose | Longer sleep, fewer interruptions, slightly more REM; a mild *waking-up* effect in the first hour |\n| 1984 | Kaeser (Basel) | Severe insomnia, 10 injections | 7 | Open label, no control group | Sleep \"normalised\" in 6 of 7 across 3–7 months |\n| 1984 | Scherschlicht et al. (Roche) | Rabbits, cats, morphine-dependent mice | Not stated | Controlled | Light non-REM up in rabbits; REM up in cats; hump-shaped dose curve throughout |\n| 1986 | Schneider-Helmert (Basel) | Long-term insomniacs, 6 × 30 nmol/kg into a vein over one week | 18 | Sleep laboratory, no placebo arm | Sleep normalised by the end of the follow-up week |\n| 1987 | Schneider-Helmert (Basel) | Severe long-term insomnia, 7 nights running | 14 | Blinded, placebo-controlled | Large improvement in night sleep and daytime performance; the effect carried into a post-treatment placebo night |\n| 1987 | Monti et al. (Montevideo) | Long-term insomniacs, into a vein, 25 nmol/kg, 4 nights | Not stated | Blinded crossover | **Difference against placebo not significant** once the starting point was accounted for. \"Sleep improvement under DSIP treatment is of little clinical significance\" |\n| 1988 | Iyer, Marks, Kastin, McCann (Dallas) | Rats, kept awake on a rotating wheel | Not stated | Antibody blockade | The rise in slow-wave sleep and growth hormone after deprivation was blocked by anti-DSIP antiserum |\n| 1992 | Bes, Hofman, Schuur, Van Boxtel (Amsterdam) | Long-term insomniacs, into a vein, 25 nmol/kg × 3 nights | 16 (8 per arm) | Blinded, matched pairs, parallel groups | Sleep efficiency and time-to-sleep improved, **but the effects were \"weak and in part could be due to an incidental change in the placebo group\"**; no change in how the sleep felt. \"Not likely to be of major therapeutic benefit\" |\n| 1992 | van Kammen et al. (Pittsburgh) | Drug-free schizophrenic volunteers, spinal fluid assay | 15 | Observational correlation | DSIP-like material in spinal fluid tracked stage 3 and delta sleep |\n| 2006 | Kovalzon, Strekalova (Moscow) | Review | — | — | \"The hypothesis regarding DSIP as a sleep factor is extremely poorly documented and still weak\" |\n\n[[embed:source:w_jrk3aijc]]\n\n[[embed:source:w_pkhu2ho3]]\n\n[[embed:source:s2]]\n\n## Sort that table by laboratory and the pattern jumps out\n\nEvery strongly positive human result came from Basel — Schneider-Helmert, working alongside Schoenenberger, who isolated the peptide in the first place. Every group that tested it without that connection got a null or a triviality.\n\nTobler and Borbély in Zürich concluded flatly that the compound does not qualify as a sleep-promoting substance. Monti in Montevideo found the placebo comparison fall apart once the starting point was accounted for. Bes in Amsterdam found statistically real but weak effects, warned that part of the signal came from drift in the placebo group, and advised against using it.\n\nThree more facts compress the record further.\n\nNearly every human study used the same single dose, 25 nmol/kg into a vein. No dose-finding study was ever run in a person. Against a hump-shaped dose curve, testing one rung of the ladder over and over cannot rule the compound in or out. It can only tell you about that rung.\n\nEvery human study injected into a vein. The subcutaneous shot that is the entire present-day market has never been tested in a human sleep trial.\n\nAnd the total number of people ever randomly assigned to DSIP against placebo for sleep, in the whole fifty-year literature, is under forty.\n\n## In fifty years nobody has registered a trial of it\n\nAsking the ClinicalTrials.gov registry on 4 August 2026 for \"delta sleep-inducing peptide\" returns zero studies. Asking for \"emideltide\" returns zero. Asking for DSIP as a registered intervention returns zero.\n\n[[embed:source:w_z711kz2m]]\n\nNot an ongoing trial. Not a completed one. Not a terminated one. Not a withdrawn one. In fifty years, nobody has registered an attempt to settle the question the compound is named after.\n\n## The biggest human numbers in the file are about withdrawal, not sleep\n\nIn 1983 Dick, Grandjean and Tissot in Geneva gave DSIP into a vein at 25 nmol/kg, as the only treatment, to 67 patients going through withdrawal — 28 from alcohol, 39 from opiates. Twenty-seven per cent were lost or unsuitable to assess. Of the 49 who could be assessed, 48 were reported to benefit, with the physical signs settling immediately and staying settled. Anxiety took longer.\n\n[[embed:source:w_ee6vmdc4]]\n\nThe 1984 extension enrolled 107 inpatients, 47 in alcohol withdrawal and 60 in opiate withdrawal. Symptoms vanished or improved markedly in 97% of the opiate cases and 87% of the alcohol cases. Opiate patients needed more injections and took longer. It was well tolerated apart from headache in a few people.\n\n[[embed:source:w_0vnryw2z]]\n\nAn independent open trial of DSIP for coming off opioids was published by Backmund's group in Munich in 1998.\n\n[[embed:source:w_5aputa1e]]\n\nEvery one of those is an uncontrolled series. No placebo. No blinding. Doctors and nurses rating the outcome. And between 13% and 27% of the people enrolled dropped out of the analysis after the fact.\n\nHere is why that matters more than usual. Acute withdrawal is a syndrome that ends by itself over a few days whether or not you give anything. An open series in a self-limiting syndrome measures the passage of time. Two hundred people getting better on schedule tells you almost nothing that one person getting better on schedule does not.\n\nThe reasoning behind the withdrawal work is at least specific and testable. Tissot had shown that morphine, alcohol, pentobarbital and DSIP all produced spindle-heavy slow-wave sleep when injected into the bulbo-mesencephalo-thalamic recruiting system, and that naloxone — the opioid blocker — reversed all four. Young and Key confirmed that reversal independently in rats: DSIP into the lateral ventricle raised REM and non-REM sleep, and pre-treating with naloxone at a dose that hits the mu-opioid receptor blocked it.\n\n[[embed:source:w_xwm13uhv]]\n\nThat is the strongest mechanical thread in the whole file, and note what it points at: an interaction with the opioid system, not a sleep factor.\n\n## Seven patients, four different conditions, no control group\n\nThe chronic pain evidence is one pilot study. Larbig and colleagues treated seven people — migraine and vasomotor headache, long-term tinnitus, and psychogenic pain attacks — with DSIP into a vein on five days running, then five more injections every 48 to 72 hours. Pain fell significantly in six of the seven against each person's own baseline stretch, and low mood fell with it.\n\n[[embed:source:s21]]\n\nSeven patients. Four different conditions. No placebo, no blinding, and a within-person comparison against a baseline assessed after the fact, in conditions that swing on their own. It is a hypothesis-generating observation that nobody generated a hypothesis from: in the forty-two years since, no controlled pain trial of DSIP has been run.\n\n## The rat says growth hormone and the woman says no\n\nThe rat result is genuinely elegant. Iyer, Marks, Kastin and McCann kept male rats awake for four hours on a slowly turning wheel. When they were taken off it, both slow-wave sleep and growth hormone in the blood shot up. Microinjecting a highly specific anti-DSIP antibody into the third ventricle blocked both rises. Ordinary rabbit serum did not.\n\n[[embed:source:w_7lo702h8]]\n\nThe human result is the opposite. Giusti's group in Genoa gave 25 µg/kg of DSIP into a vein over thirty minutes to eight healthy women. Baseline growth hormone: unchanged. Prolactin: unchanged. The daily rhythm of both: unchanged. The growth hormone response to an arginine challenge: unchanged. The authors pointed out that the dose they used was already known to alter the ECG — so it was reaching the subject, and it was doing nothing to growth hormone.\n\n[[embed:source:w_zga2djoc]]\n\nMarketing copy that promises a growth hormone release is citing the rat and ignoring the woman.\n\nLuteinising hormone runs the same course. DSIP triggered LH release in ovary-removed rats that had been primed with oestrogen and progesterone, did nothing in unprimed animals, and did nothing at all to pituitary tissue in a dish — meaning any effect is happening in the hypothalamus and depends on the hormonal background.\n\n[[embed:source:w_lq5x8aor]]\n\nDSIP-like material has been found sitting in the same storage vesicles as LH-releasing hormone in the rat median eminence, which is suggestive. No endocrine effect of DSIP in a human being has ever been shown by anybody.\n\n## The stress work is the most internally consistent animal data\n\nRats given DSIP into the belly at 40, 120, 360 and 1080 µg/kg before acute and repeated electric foot-shock showed liver malondialdehyde back to normal, liver cell protein production restored, and serum alanine aminotransferase back to normal. The dose curve was again a hump, not a slope: 120 µg/kg normalised fat oxidation damage in acute stress, while 40 µg/kg was the effective dose under chronic stress.\n\n[[embed:source:w_cqubqjkn]]\n\nDSIP and its analogue DSIP-12 cut the frequency, severity and length of metaphit-triggered sound-induced seizures in rats, with the analogue beating the parent compound.\n\n[[embed:source:w_1pggv0x0]]\n\nSchoenenberger's own characterisation work reported effects on the daily activity rhythm, on brain monoamine levels, on plasma proteins and on cortisol — a spread wide enough that he coined the phrase \"programming functions\" rather than claiming a mechanism.\n\nTwo caveats attach here. Most of this literature comes from Russian, Ukrainian and Serbian laboratories, much of it published in Russian, and very little has been repeated outside those groups. And an effect on rodent liver enzymes under electric shock is a long way from anything you can act on.\n\n## Fifty years of looking and nobody has found the receptor\n\nThis is the strangest fact about DSIP and the one that should carry the most weight. For a peptide under continuous study since the 1970s, no gene, no precursor protein and no receptor has ever been isolated.\n\n[[embed:source:w_l0pqsfj3]]\n\nWhat exists instead:\n\n- **Binding sites, never a receptor.** Autoradiography in 1984 found tritium-labelled DSIP sticking to the bodies and branches of cultured rat brain-stem neurones, and unlabelled peptide pushed it off. That observation is forty-two years old and was never followed through into a cloned receptor.\n- **The material shows up in the wrong places.** DSIP-like material concentrates in hypothalamic neurosecretory nuclei that have little to do with sleep. Kovalzon's reading is that the material being detected belongs to a different, related molecule nobody has identified — which would explain both the distribution and the erratic biology.\n- **Artificial versions work better than the real one.** Kovalzon's group found that certain man-made DSIP analogues significantly promote slow-wave sleep in rabbits and rats, and that DSIP itself does not. A naturally occurring dermorphin ten-residue peptide sharing five of nine positions promotes slow-wave sleep, while its mirror-image form suppresses it.\n- **An adrenaline hypothesis that failed its test.** Graf and Kastin's 1986 review proposed that DSIP works by changing adrenaline-type transmission. Direct testing found DSIP did nothing to noradrenaline release from rat brain nerve endings at concentrations from 10⁻⁸ to 10⁻⁵ M, while leu-enkephalin in the same preparation did.\n- **An opioid interaction that passed.** The naloxone reversal replicated. It remains the only mechanical claim about DSIP with independent support.\n\n[[embed:source:s53]]\n\n## It gets into the brain and then it is gone in four minutes\n\nDSIP is one of the small set of peptides shown to cross from blood into brain by simple diffusion despite carrying a charge and liking water — a finding that made it a standard test compound in blood-brain barrier research. How much reaches dog spinal fluid tracks its blood concentration, its survival time in blood, and how fat-soluble it is.\n\n[[embed:source:s7]]\n\nThen the clearance numbers undo the story. Kato and colleagues built an enzyme immunoassay and measured it directly after injection into a vein:\n\n| Species | Half gone from blood in | Clearance rate |\n|---|---|---|\n| Dog (n=4, anaesthetised) | 4.0 ± 0.7 min | 30.7 ± 2.5 mL/kg/min |\n| Monkey (n=1) | 2.9 min | — |\n| Rat (n=3) | 2.0 ± 0.54 min | — |\n\n[[embed:source:w_w4ku9pni]]\n\nBreakdown is why. Put DSIP in human or rat blood and what comes back has the fingerprint of free tryptophan — the front residue gets snipped off and the intact peptide stops existing. Phosphorylated and iodine-labelled versions break down more slowly and form complexes, which is the proposed reason they act more strongly and more consistently than the plain peptide.\n\n[[embed:source:w_nxo79twi]]\n\nNow put that number next to the claim being made. A compound that is half gone from your blood in two to four minutes, injected before bed, is absent from your circulation for essentially the entire night it is supposed to be governing.\n\nTwo readings survive that, and only two.\n\nEither the injection is a brief trigger that starts something slower downstream — and the one piece of evidence for that is Schneider-Helmert's observation that the improvement carried into a post-treatment placebo night.\n\nOr the reported effects are not the compound.\n\nNobody has run the experiment that separates those two.\n\nOne more thing sits underneath it. The DSIP-like material your body carries in blood, urine and spinal fluid appears to be bound to a larger carrier protein and protected from being chewed up. Injected synthetic peptide is not bound to anything.\n\n## What people taking it report, counted: 18 better, 10 worse, 5 nothing, of 35\n\nForty-five Reddit threads and comments about DSIP are catalogued as sources on this page, pulled on 29 June 2026. Ten of them are protocol questions, vendor posts and guides with no outcome in them. That leaves **35 posts where a named person says what they took and what happened.**\n\n| What was reported | Posts | Share of the 35 |\n|---|---|---|\n| Sleep improved | 18 | 51% |\n| Sleep got worse, or a new bad effect appeared | 10 | 29% |\n| Nothing at all | 5 | 14% |\n| Worked, then stopped working | 1 | 3% |\n| Mixed — one sleep measure moved, the others did not | 1 | 3% |\n\nEighteen X posts and two Instagram reels are also catalogued and are deliberately **not** counted in that 35. They run overwhelmingly positive, and on those platforms a first-hand report and an advertisement are not reliably distinguishable.\n\nThis is a curated set, not a survey, and the direction of the curation is unknown. Read it only for the shape: **about half the people who bothered to write down what happened reported no benefit or an active harm.** That is not the distribution a working sleeping pill produces. It is the same split the controlled trials produced, reached by a completely different route.\n\n### The 18 reports of improvement are vivid and specific\n\nFirst night, tracked on a wearable:\n\n[[embed:source:s43]]\n\nDeep and REM each up by about forty minutes, with the writer noting tolerance appearing after three or four days:\n\n[[embed:source:s10]]\n\nThe dream reports are their own category and they are consistent enough to be worth reading as a signal rather than as colour:\n\n[[embed:source:s9]]\n\n[[embed:source:s63]]\n\nLong-run users. Two years on it, off a self-experimentation forum:\n\n[[embed:source:s19]]\n\nThree weeks before anything changed, then months with no tolerance, at 300–500 mcg under the skin:\n\n[[embed:source:s78]]\n\nSleep going from three to five hours a night to seven to nine, after alcohol withdrawal wrecked it:\n\n[[embed:source:s74]]\n\n[[embed:source:s58]]\n\n[[embed:source:s101]]\n\n[[embed:source:s75]]\n\n[[embed:source:s65]]\n\n[[embed:source:s98]]\n\n[[embed:source:s26]]\n\n[[embed:source:s27]]\n\n[[embed:source:s42]]\n\n[[embed:source:s62]]\n\n[[embed:source:s18]]\n\n[[embed:source:s81]]\n\n### The 5 reports of nothing happening are just as specific\n\nTwo full vials, dosed under a doctor's direction:\n\n[[embed:source:s20]]\n\n[[embed:source:s41]]\n\nA full 5 mg vial, from a commenter under one of the enthusiastic posts above:\n\n[[embed:source:s44]]\n\nTwo months, in someone whose sleep was already good:\n\n[[embed:source:s59]]\n\n125 mcg in the day and about 300 mcg before bed:\n\n[[embed:source:s100]]\n\n### The 10 reports where it made sleep worse are the ones vendor pages never carry\n\nStraightforward insomnia from a sleeping compound:\n\n[[embed:source:s77]]\n\n[[embed:source:s93]]\n\n[[embed:source:s94]]\n\n[[embed:source:s95]]\n\nFour hours of sleep, from someone who ran it for sleep-maintenance insomnia:\n\n[[embed:source:s73]]\n\nDeep sleep measured going the wrong way — 45 minutes a night down to 8 by day five:\n\n[[embed:source:s76]]\n\n[[embed:source:s72]]\n\n[[embed:source:s64]]\n\nWorked for sleep and produced a hangover the next day:\n\n[[embed:source:s66]]\n\nLongest uninterrupted sleep the tracker had ever recorded, followed by two hours of lying awake on subsequent nights:\n\n[[embed:source:s57]]\n\nSleep getting *worse* deserves more attention than it usually gets, because it is neither the shape of an inert compound nor the shape of a placebo. Two things in the published record line up with it directly.\n\nSchneider-Helmert's 1981 study found a mild **waking-up** effect in the first hour after injection, before any sleep-promoting effect showed up. People are injecting fifteen to sixty minutes before bed, which puts the dose squarely inside that first hour.\n\nAnd the dose curve reported throughout the animal literature is a hump. A dose past the peak can plausibly do the opposite of the dose at the peak. That curve has never been mapped in a human being, at any dose, by anyone.\n\n### One report describes tolerance, and nothing in the literature addresses it\n\n[[embed:source:s17]]\n\nNo human study ran longer than seven nights in a row. Whether an effect survives weeks of nightly use has never been tested by anybody.\n\n### One report is mixed, and it is the most precise in the set\n\nSleep length and deep sleep unchanged, but REM present every night where it had not been before:\n\n[[embed:source:s96]]\n\n### Two threads independently reproduce the 1980s withdrawal finding\n\nThe most unexpected corroboration in the self-report record is not about sleep at all. People treating opiate withdrawal describe relief from DSIP under the skin and up the nose in terms close to Dick's Geneva series of 1983 — forty-two years later, with no sign of knowing that series exists.\n\n[[embed:source:s97]]\n\nThat does not make the withdrawal claim true. Uncontrolled reports of a self-limiting syndrome resolving are still uncontrolled reports. What it does mean is that the strongest signal in the published record and the strongest signal in the self-report record point at the same non-sleep use, which is worth more than another sleep testimonial.\n\n### Why none of it settles the question\n\nSleep is the outcome most sensitive to what you expect, and self-report is the weakest instrument for measuring it. One detail from the controlled record cuts against dismissing the whole thing, though. In the Bes trial the objective polysomnography numbers improved while how the sleep *felt* did not. That is the reverse of a placebo signature — placebo moves the feeling first. The authors still judged the effect weak, partly attributable to drift in the placebo group, and advised against using it. That position remains more defensible than either the enthusiasts' or the debunkers'.\n\n## Sleep does gate pain and repair, and that is not evidence about this compound\n\nIf you are here because pain is keeping you awake, or because being awake is making the pain worse, the link is real and it is well documented. It is also a completely different proposition from anything above, and keeping the two apart is the whole job of this section.\n\n**Poor sleep predicts new and worsening pain more reliably than pain predicts poor sleep.** Population studies following people over time show sleep problems arriving before new pain and before flare-ups. Fine-grained work with objective measures on both sides finds the sleep-to-pain direction is the stronger one.\n\n[[embed:source:w_47nktqzd]]\n\n**One night without sleep measurably lowers your pain threshold.** Acute sleep deprivation amplifies the pain response in primary somatosensory cortex, blunts it in the striatum and insula, and widens the range of temperatures a person calls painful. Outside the laboratory, ordinary night-to-night changes in one person's sleep quality predict next-day changes in their pain, in both directions.\n\n[[embed:source:w_9shvk46m]]\n\n**Two nights of partial restriction is enough to change a pressure pain threshold at the trapezius.** Twenty-one healthy volunteers, paired crossover, sleep cut by half for two nights: pressure pain threshold at the trapezius fell, p = 0.017, and the pain-triggered EEG response got bigger.\n\n[[embed:source:w_2zo637na]]\n\n**Broken sleep slows healing in animals.** Fragmenting sleep stretched the time to half-closure of a wound from 10.3 to 13.3 days in diabetic mice, with more TNF-α in the wound. Sleep-deprived rats healing burns grew fewer tissue-building cells and fewer new capillaries than controls.\n\n[[embed:source:w_ikb821wn]]\n\n[[embed:source:w_7fiszq9g]]\n\nNow the line, drawn as sharply as it needs to be.\n\nAll of that is evidence that **sleep** matters to pain and to repair. None of it is evidence that **DSIP** improves sleep. The first proposition has population studies, controlled human experiments and animal tissue work behind it. The second has an inconsistent fifty-year record concentrated in one laboratory and a self-report split that is close to a coin flip.\n\nTreating the strength of the first as if it transfers to the second is the exact move the marketing around this compound depends on. The evidence for one thing gets handed over while a different thing is sold. It is worth being able to see it happen, because it happens in one sentence and the sentence sounds reasonable.\n\n## If the goal is sleep, here is what actually has the evidence\n\n**Cognitive behavioural therapy for insomnia.** Twenty randomised controlled trials, 1,162 participants. Time to fall asleep improved by 19.0 minutes (95% CI 14.1–23.9). Time spent awake after falling asleep improved by 26.0 minutes (95% CI 15.5–36.5). Sleep efficiency improved by 9.9% (95% CI 8.1–11.7). The gains held at later follow-up and no harms were reported. It is first-line in the guidelines for a reason, and its two active ingredients — restricting time in bed, and using the bed only for sleep — need no prescription and cost nothing.\n\n[[embed:source:w_363tewrt]]\n\n**Licensed sleeping pills, with their costs stated.** The largest network meta-analysis covers 170 trials and 47,950 participants. Benzodiazepines, doxylamine, eszopiclone, lemborexant, seltorexant, zolpidem and zopiclone all beat placebo for short-term treatment, with standardised effect sizes from 0.36 to 0.83. Eszopiclone and lemborexant came out with the best overall profiles. Zopiclone and zolpidem caused more people to quit over side effects than placebo did.\n\n[[embed:source:w_ry66bqki]]\n\n**And the one most people have already tried, which does not work.** In that same analysis, melatonin, ramelteon and the unlicensed drugs showed no material benefit overall.\n\nSet the comparison out plainly, because it is the comparison that matters. The best-evidenced sleep intervention rests on 1,162 randomly assigned people, with an effect that lasted and no harms recorded. The best-evidenced DSIP sleep trial rests on eight people per arm and concluded that short-term treatment was not likely to be of major benefit.\n\n## Dosing, and the gap between the studies and what is sold\n\nEvery human trial used 25 nmol/kg into a vein. At a molecular weight of 849 that is 21.2 µg/kg — about 1.5 mg for a 70 kg adult. Schneider-Helmert's 1986 week-long study used 30 nmol/kg. Giusti's endocrine study used 25 µg/kg into a vein over thirty minutes.\n\nThe market dose is 100 to 300 mcg under the skin before bed.\n\nThat is five to fifteen times lower than the only dose ever given to a human being, by a route never tested in one. Both changes are undocumented. Against a compound whose dose curve is a hump rather than a slope, cutting the dose fifteen-fold is not the cautious choice. It is an untested choice, and it can land anywhere on that curve including flat zero.\n\nTiming in the circulating protocols is 15 to 60 minutes before you intend to sleep. Worth knowing before you set that: Schneider-Helmert's 1981 study found the mild waking-up effect in the first hour after injection, with the sleep-promoting effect only turning up in the second.\n\n[[embed:source:s3]]\n\nUnder the skin and up the nose are the two routes in circulation. There is no comparative human data, and nothing has ever been published on how the body absorbs and clears the nasal form.\n\n### Mixing a vial is arithmetic\n\nDSIP ships as a dry powder in a sealed glass vial, usually 2 mg or 5 mg. You mix it with bacteriostatic water — sterile water with 0.9% benzyl alcohol in it, the preservative that makes it safe to put a needle into the same vial more than once. The measuring device is a U-100 insulin syringe: 100 marks per millilitre, so one mark is 0.01 mL.\n\nTwo lines produce every number you need:\n\n- Concentration in mcg per mL = total mcg in the vial ÷ mL of water added.\n- Mcg per mark = concentration ÷ 100.\n\nWorked through: a 5 mg vial holds 5,000 mcg. Add 2.5 mL of bacteriostatic water. 5,000 ÷ 2.5 = 2,000 mcg/mL. 2,000 ÷ 100 = 20 mcg per mark. A 100 mcg dose is 100 ÷ 20 = 5 marks on the barrel.\n\n| Vial | Bacteriostatic water | Concentration | Mcg per mark | Marks for 100 mcg | Marks for 200 mcg | Marks for 300 mcg |\n|---|---|---|---|---|---|---|\n| 2 mg (2,000 mcg) | 2.0 mL | 1,000 mcg/mL | 10 | 10 | 20 | 30 |\n| 2 mg (2,000 mcg) | 1.0 mL | 2,000 mcg/mL | 20 | 5 | 10 | 15 |\n| 5 mg (5,000 mcg) | 2.0 mL | 2,500 mcg/mL | 25 | 4 | 8 | 12 |\n| 5 mg (5,000 mcg) | 2.5 mL | 2,000 mcg/mL | 20 | 5 | 10 | 15 |\n| 5 mg (5,000 mcg) | 5.0 mL | 1,000 mcg/mL | 10 | 10 | 20 | 30 |\n| 10 mg (10,000 mcg) | 5.0 mL | 2,000 mcg/mL | 20 | 5 | 10 | 15 |\n\nAdding more water does not change how much peptide is in the vial. It changes only how many marks carry a given dose. Below about five marks, the error in reading a U-100 barrel starts to dominate your dose — which is the practical argument for more water, not less, at the 100 mcg tier.\n\nLet the vial come to room temperature before you add water. Run the water down the inside wall instead of squirting it onto the powder. Swirl until it dissolves and never shake it: the shearing at the air-liquid surface unfolds peptides and makes them clump, and clumping is exactly the mechanism FDA named when it raised the question of whether the immune system would react to it.\n\n### Storage has a hard clock\n\n| State | Temperature | How long it is good for |\n|---|---|---|\n| Sealed dry vial | 2–8 °C, out of the light | To the manufacturer's date; −20 °C for long holding |\n| Mixed with bacteriostatic water | 2–8 °C | About four weeks, set by the preservative |\n| Mixed, left at room temperature | 20–25 °C | Hours to days; treat it as spoiled |\n| Mixed, then frozen | −20 °C | Avoid. Freezing and thawing clumps peptides |\n\nA 5 mg vial at 100 mcg a night is fifty doses, which is far more nights than the four-week window a mixed vial gives you. The arithmetic forces a choice: buy a smaller vial, take a bigger nightly dose, or throw most of what you paid for away.\n\n### Timelines, and what would count as an answer\n\nThe circulating protocols run five nights on and two off, or three to five nights a week, for four to eight weeks. There is no evidence base under any of those schedules. No human study of DSIP ran longer than seven nights in a row, and none tested taking it on and off.\n\nThe trial that would settle it is easy to specify and has never been run: randomised, blinded, placebo-controlled, with overnight sleep recording, in long-term insomnia, DSIP under the skin at 100–300 mcg — the doses that are actually sold — with sleep efficiency and minutes of slow-wave sleep as the primary outcomes. Anything short of that leaves the position exactly where 1980 left it.\n\n## Regulatory status: withdrawn by the nominator, not cleared by the agency\n\nEmideltide, the international nonproprietary name for DSIP, appears on FDA's page *Certain Bulk Drug Substances for Use in Compounding That May Present Significant Safety Risks*, in the table headed **\"Bulk drug substances nominated but withdrawn\"**. It is one of seventeen entries there, alongside BPC-157, TB-500, KPV, Semax, Selank acetate, Thymosin alpha-1, Epitalon, MOTS-C, Melanotan II, CJC-1295, AOD-9604 and GHK-Cu.\n\nFDA's stated reason, word for word: compounded drugs containing emideltide \"may pose risk for immunogenicity for certain routes of administration and may have complexities with regard to peptide-related impurities and API characterization. FDA has not identified safety-related information regarding emideltide for the proposed route... Therefore, the agency lacks sufficient information to know whether the drug would cause harm if administered to humans.\"\n\n[[embed:source:w_ww3yt0x9]]\n\nWhat that status means, precisely:\n\n- It is **not an approval** and it is **not a ban**. It is the record of a request. Somebody asked FDA to allow emideltide as a bulk substance for pharmacy compounding; FDA put it in category 2 — substances that may present significant safety risks; the person who asked then withdrew the request. FDA's own words on the page are that these substances were \"previously in category 2 of the interim policies\" and \"were withdrawn by the nominators.\"\n- The practical consequence is that emideltide is **not on the 503A or 503B bulks lists**. A compounding pharmacy cannot lawfully compound it as a bulk drug substance. What is offered for sale is research-use-only chemical, not medicine, and it comes with no assurance of identity, purity or sterility.\n- FDA's specific worries are, in order: clumping and whether the immune system would react to it by certain routes, peptide-related impurities, characterisation of the active ingredient, and — the operative one — an absence of safety information for the route being proposed.\n- No marketing authorisation for DSIP exists in any country, and none has ever been applied for.\n\n[[embed:source:s56]]\n\nA 2026 review of therapeutic peptides in orthopaedics lists DSIP among the recovery-oriented compounds and states the position for the whole class in one line: the preclinical work looks good, and there are no clinical trials.\n\n[[embed:source:w_d2edzzyj]]\n\n## Where that leaves the compound\n\nA confirmed nine-residue sequence.\n\nHalf gone from the blood in two to four minutes.\n\nNo gene, no precursor, no receptor, after fifty years of people looking for all three.\n\nA sleep record whose positive findings are concentrated in the laboratory that discovered it, and whose independent replications are null.\n\nA withdrawal literature covering several hundred patients with no control group in any of it, in a syndrome that ends on its own.\n\nOne seven-patient pain pilot, never followed up in forty-two years.\n\nA growth hormone claim that holds in rats and fails in the only eight humans it was ever tested in.\n\nZero registered trials, ever.\n\nThirty-five first-hand reports splitting eighteen good, ten bad, five nothing.\n\nAnd a regulatory file recording a withdrawn request and an agency saying it does not have enough information to know whether the substance would hurt you.\n\nThe peptide is named for the one effect its evidence supports least.\n\nThe sibling objects for this page, each one inspectable on its own terms:\n\n[[embed:bpc-157]]\n\n[[embed:kpv]]\n\n[[embed:ghk-cu]]\n\n[[embed:thymosin-alpha-1]]\n\n[[embed:ara-290]]\n","hero":"https://miscsubjects.com/img/gen/arcads-gpt-image-2b2483da-3951-4d1f-a958-fe10e99a05af.png","images":[],"style":{},"tags":["peptide","dsip"],"category":null,"model":"grok/grok-4.3","ledger":{"href":"/api/articles/dsip/ledger","live":true},"embeds":["bpc-157","kpv","ghk-cu","thymosin-alpha-1","ara-290"],"widgets":[],"home":true,"claims":[{"id":"c1","text":"In rats kept awake, the deep slow-wave sleep and the growth-hormone surge that normally follow both failed to appear once an antibody against DSIP was injected into a fluid space inside the brain.","section":"What DSIP did in rabbits, rats, cats and mice","tier":"preclinical","source_ids":["s1"],"source_status":"sourced","why_material":"Separates rat data from human evidence.","evidence_basis":"derived_inference","weight":0.22,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{},"who_claims":"system/unknown","posted_by":{"actor":"system/unknown","channel":"protocol/repair","ts":"2026-06-29T12:45:19.402Z","model":"grok/grok-4.3","rationale":"backfilled by ledger repair"},"slot":"what_is_known","source_role":"mechanism_support"},{"id":"c2","text":"In a 1992 double-blind trial, 16 people with long-running insomnia fell asleep faster and spent more of their time in bed actually asleep on DSIP than on placebo. They themselves noticed no difference.","section":"What the small human trials of DSIP actually found","tier":"human","source_ids":["s2"],"source_status":"sourced","why_material":"Primary human trial result, small sample noted.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{},"who_claims":"system/unknown","posted_by":{"actor":"system/unknown","channel":"protocol/repair","ts":"2026-06-29T12:45:19.402Z","model":"grok/grok-4.3","rationale":"backfilled by ledger repair"},"slot":"what_is_known","challenged_by":["c92"],"source_role":"mechanism_support"},{"id":"c3","text":"In a 1981 study of 6 people whose sleep was disturbed, DSIP lengthened sleep, cut the number of times they woke, and slightly raised REM, with no next-day dopiness.","section":"What the small human trials of DSIP actually found","tier":"mechanistic","source_ids":["s3"],"source_status":"sourced","why_material":"Additional small human trial separating from preclinical.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{},"who_claims":"system/unknown","posted_by":{"actor":"system/unknown","channel":"protocol/repair","ts":"2026-06-29T12:45:19.402Z","model":"grok/grok-4.3","rationale":"backfilled by ledger repair"},"slot":"what_is_known","source_role":"mechanism_support"},{"id":"c4","text":"A review reported that DSIP brought on sleep in rabbits, mice, rats, cats and human beings.","section":"What DSIP did in rabbits, rats, cats and mice","tier":"speculative","source_ids":["s4"],"source_status":"sourced","why_material":"Animal species-specific data.","evidence_basis":"derived_inference","weight":0.12,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{},"who_claims":"system/unknown","posted_by":{"actor":"system/unknown","channel":"protocol/repair","ts":"2026-06-29T12:45:19.402Z","model":"grok/grok-4.3","rationale":"backfilled by ledger repair"},"slot":"what_is_known","source_role":"mechanism_support"},{"id":"c5","text":"One person tracking their sleep said their deep sleep went, in their words, \"soooo high\" on DSIP, and that it did not leave them feeling tired.","section":"People who report that DSIP deepened their sleep","tier":"anecdotal","source_ids":["s5"],"source_status":"sourced","why_material":"Distinguishes user reports from trials.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{},"who_claims":"system/unknown","posted_by":{"actor":"system/unknown","channel":"protocol/repair","ts":"2026-06-29T12:45:19.402Z","model":"grok/grok-4.3","rationale":"backfilled by ledger repair"},"slot":"who_claims_what","source_role":"anecdotal_report"},{"id":"c6","text":"8 commercial and clinic pages selling or promoting DSIP are catalogued on this page. They are marketing copy, and none of them is evidence.","section":"Sellers and promotional posts pushing DSIP","tier":"speculative","weight":0.12,"status":"active","source_ids":["s16","s28","s29","s33","s50","s54","s56","s1"],"source_status":"sourced","who_claims":"commercial vendors","posted_by":{"actor":"system/protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:45:20.133Z","model":"system/audit-repair","rationale":""},"why_material":"Collapsed 14 duplicate marketing claims","slot":"who_claims_what","register":null},{"id":"c10","text":"This page is not medical advice. It is a catalogue of what has been claimed about DSIP, with the strength of the evidence marked on each claim, and decisions about your own health belong with a qualified professional.","section":"What this DSIP page is, and what it is not","tier":"human","weight":0.8,"status":"active","source_ids":[],"source_status":"unsourced","who_claims":"system/protocol","posted_by":{"actor":"system/protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:45:20.670Z","model":"system/audit-repair","rationale":""},"why_material":"Required constitution slot: disclaimer","slot":"disclaimer","register":null},{"id":"c11","text":"A 2006 review walked through where DSIP came from, starting with its isolation from rabbit blood, and set out which parts of the story were still unsettled.","tier":"human","weight":0.8,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"what_is_known","source_ids":["s6"],"source_status":"sourced","why_material":"Materialized from orphan source s6 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c12","text":"A 2024 paper described DSIP welded onto a carrier peptide so that more of it would cross from the blood into the brain, and tested whether the joined peptide still brought on sleep.","tier":"human","weight":0.8,"section":"What DSIP did in rabbits, rats, cats and mice","slot":"what_is_known","source_ids":["s7"],"source_status":"sourced","why_material":"Materialized from orphan source s7 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c13","text":"In a 2021 experiment, rats given a stroke got their movement back faster when DSIP was sprayed into the nose each day for 8 days.","tier":"preclinical","weight":0.5,"section":"The rat stroke experiment with DSIP sprayed into the nose","slot":"what_is_known","source_ids":["s8"],"source_status":"sourced","why_material":"Materialized from orphan source s8 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c14","text":"One person taking 500mcg described dreams three layers deep and a couple of lucid ones, and said they woke up rested.","tier":"anecdotal","weight":0.3,"section":"The vivid dreams people keep reporting on DSIP","slot":"who_claims_what","source_ids":["s9"],"source_status":"sourced","why_material":"Materialized from orphan source s9 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c15","text":"One person said their first night on DSIP added roughly 40 minutes each to their deep sleep and their REM.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s10"],"source_status":"sourced","why_material":"Materialized from orphan source s10 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c300","text":"That same person said the effect faded on them after 3-4 days of nightly use.","tier":"anecdotal","weight":0.3,"section":"Whether DSIP keeps working, or stops","slot":"who_claims_what","source_ids":["s10"],"source_status":"sourced","why_material":"Materialized from orphan source s10 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c16","text":"A 2025 video ran through DSIP for sleep, stress and pain, and stated plainly that it has no FDA approval.","tier":"anecdotal","weight":0.3,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"who_claims_what","source_ids":["s11"],"source_status":"sourced","why_material":"Materialized from orphan source s11 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c17","text":"A 2026 rundown pointed out that most of the DSIP sleep research is animal work, and that the handful of human trials all date from the 1980s.","tier":"speculative","weight":0.12,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"what_is_known","source_ids":["s12"],"source_status":"sourced","why_material":"Materialized from orphan source s12 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"adjacent_context"},{"id":"c18","text":"The same 2021 rat stroke study, catalogued again from a second copy of the write-up: the rats walked better on the rolling-rod test, while the damaged patch of brain did not shrink by a meaningful amount.","tier":"speculative","weight":0.12,"section":"The rat stroke experiment with DSIP sprayed into the nose","slot":"what_is_known","source_ids":["s13"],"source_status":"sourced","why_material":"Materialized from orphan source s13 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"adjacent_context"},{"id":"c19","text":"A 2026 video set out the leading guess about DSIP: that it leans on GABA receptors, the brain’s main calming switch.","tier":"anecdotal","weight":0.3,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s14"],"source_status":"sourced","why_material":"Materialized from orphan source s14 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c302","text":"That video also said the human studies on DSIP are inconclusive and that no regulator has approved it.","tier":"anecdotal","weight":0.3,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s14"],"source_status":"sourced","why_material":"Materialized from orphan source s14 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c301","text":"The same video described DSIP acting on the stress circuit that runs from the brain down to the adrenal glands, damping the ACTH and cortisol signal.","tier":"anecdotal","weight":0.3,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s14"],"source_status":"sourced","why_material":"Materialized from orphan source s14 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c20","text":"A 2026 thread in the Biohackers forum asked who had taken DSIP above 1.5 mg a night, and gathered what people said high doses did to them.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s15"],"source_status":"sourced","why_material":"Materialized from orphan source s15 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c22","text":"One person took DSIP for about 3 months and said it stopped working in the final month. They tried two different suppliers, got nothing either way, and moved on to other sleep aids.","tier":"anecdotal","weight":0.3,"section":"Whether DSIP keeps working, or stops","slot":"who_claims_what","source_ids":["s17"],"source_status":"sourced","why_material":"Materialized from orphan source s17 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c23","text":"The same dream report at 500mcg, ingested a second time from another copy of the post: extremely vivid layered dreams, a couple of lucid ones, and waking up well rested.","tier":"anecdotal","weight":0.3,"section":"The vivid dreams people keep reporting on DSIP","slot":"who_claims_what","source_ids":["s18"],"source_status":"sourced","why_material":"Materialized from orphan source s18 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c24","text":"Someone who has injected DSIP under the skin for 2 years says they now sleep through the night, drop straight back off after a bathroom trip, and dream every night.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s19"],"source_status":"sourced","why_material":"Materialized from orphan source s19 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c25","text":"One person tried DSIP twice, a full vial each time, with the dose set by a licensed doctor, and got nothing from it.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP did nothing at all","slot":"who_claims_what","source_ids":["s20"],"source_status":"sourced","why_material":"Materialized from orphan source s20 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c26","text":"In a 1984 study, DSIP given into a vein on 5 days running and then every 48 to 72 hours brought the pain down in 6 of the 7 people with severe, long-running pain.","tier":"human","weight":0.8,"section":"What the small human trials of DSIP actually found","slot":"what_is_known","source_ids":["s21"],"source_status":"sourced","why_material":"Materialized from orphan source s21 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c27","text":"In a 1987 study of people with severe long-running insomnia, night sleep improved substantially on the first dose of DSIP and improved further with repeated doses.","tier":"mechanistic","weight":0.3,"section":"What the small human trials of DSIP actually found","slot":"what_is_known","source_ids":["s22"],"source_status":"sourced","why_material":"Materialized from orphan source s22 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c303","text":"In that same 1987 study, daytime alertness and daytime performance both rose by a clear margin.","tier":"mechanistic","weight":0.3,"section":"What the small human trials of DSIP actually found","slot":"what_is_known","source_ids":["s22"],"source_status":"sourced","why_material":"Materialized from orphan source s22 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c28","text":"A 2026 write-up gathers the DSIP research on sleep, stress and brain health and gives dosing figures. It adds no data of its own.","tier":"speculative","weight":0.12,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"what_is_known","source_ids":["s23"],"source_status":"sourced","why_material":"Materialized from orphan source s23 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"adjacent_context"},{"id":"c29","text":"A 2026 overview covers what DSIP is claimed to do, how it is dosed, and where it sits with the FDA and with compounding pharmacies.","tier":"speculative","weight":0.12,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"what_is_known","source_ids":["s24"],"source_status":"sourced","why_material":"Materialized from orphan source s24 by ledger 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It is sales copy, not a study.","tier":"speculative","weight":0.12,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s37"],"source_status":"sourced","why_material":"Materialized from orphan source s37 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"adjacent_context"},{"id":"c43","text":"A 2025 post from a lifter said DSIP gives them heavy sleep every night and strong energy every morning, and that the better sleep showed up in their training.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s38"],"source_status":"sourced","why_material":"Materialized from orphan source s38 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c44","text":"A 2026 post described going from barely sleeping at all to 100mcg under the skin before bed, then waking 9 hours later having actually dreamt, vividly, and not groggy.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s39"],"source_status":"sourced","why_material":"Materialized from orphan source s39 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c45","text":"A 2026 Instagram reel describes DSIP as a naturally occurring peptide studied for deeper REM and slow-wave sleep, and notes that it has no FDA approval and can carry side effects.","tier":"anecdotal","weight":0.3,"section":"Sellers and promotional posts pushing DSIP","slot":"who_claims_what","source_ids":["s40"],"source_status":"sourced","why_material":"Materialized from orphan source s40 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c46","text":"The same report of nothing at all happening after two full vials under a doctor’s direction, ingested again from a second copy of the thread.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP did nothing at all","slot":"who_claims_what","source_ids":["s41"],"source_status":"sourced","why_material":"Materialized from orphan source s41 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c47","text":"A person with narcolepsy and fibromyalgia said their first 100mcg dose gave them the hardest sleep they had had in a long time. They were still tired the next day, but far less than usual.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s42"],"source_status":"sourced","why_material":"Materialized from orphan source s42 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c48","text":"On a first dose of 100 to 120mcg, one person’s tracker showed more restorative deep sleep in that single night than in the previous 3 days put together.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s43"],"source_status":"sourced","why_material":"Materialized from orphan source s43 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c49","text":"Another person went through a whole 5mg vial of DSIP and could not point to a single benefit from it.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP did nothing at all","slot":"who_claims_what","source_ids":["s44"],"source_status":"sourced","why_material":"Materialized from orphan source s44 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c50","text":"Someone who had woken at two or three in the morning every night for ten years of insomnia said DSIP is the only thing that keeps them asleep, and that it also brings down their wired feeling without wrecking their day.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s45"],"source_status":"sourced","why_material":"Materialized from orphan source s45 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c51","text":"A 2021 study found that a DSIP-like peptide called KND shrank the area of brain damage in mice when it was given as blood flow came back after a stroke.","tier":"preclinical","weight":0.22,"section":"What DSIP did in rabbits, rats, cats and mice","slot":"what_is_known","source_ids":["s46"],"source_status":"sourced","why_material":"Materialized from orphan source s46 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c52","text":"A 2023 video guide walks through the science behind DSIP and what it is claimed to do for deep sleep.","tier":"anecdotal","weight":0.3,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"who_claims_what","source_ids":["s47"],"source_status":"sourced","why_material":"Materialized from orphan source s47 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c53","text":"Someone two days without real sleep posted in a peptide forum asking about DSIP. No outcome was ever reported in the thread.","tier":"anecdotal","weight":0.3,"section":"DSIP threads where somebody asked first and never reported back","slot":"who_claims_what","source_ids":["s48"],"source_status":"sourced","why_material":"Materialized from orphan source s48 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c54","text":"A person already taking a benzodiazepine for sleep asked whether the DSIP their doctor was offering was worth buying, and got back a mix of personal experience and advice about buying it on the grey market instead.","tier":"anecdotal","weight":0.3,"section":"Where people say their DSIP came from","slot":"who_claims_what","source_ids":["s49"],"source_status":"sourced","why_material":"Materialized from orphan source s49 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c56","text":"A 2024 study put the DSIP fusion peptide into mice whose sleep had been wrecked with a drug, and measured both their sleep and the balance of their brain-signalling chemicals.","tier":"preclinical","weight":0.22,"section":"What DSIP did in rabbits, rats, cats and mice","slot":"what_is_known","source_ids":["s51"],"source_status":"sourced","why_material":"Materialized from orphan source s51 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c57","text":"A discussion thread argued that when DSIP is doing what it is meant to do, the body sits further into rest-and-digest mode, and that this is a bigger thing than sleep alone.","tier":"anecdotal","weight":0.3,"section":"What people report from DSIP other than sleep","slot":"who_claims_what","source_ids":["s52"],"source_status":"sourced","why_material":"Materialized from orphan source s52 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c58","text":"A 1986 review pulled together everything published on DSIP since the work that isolated it, which ran from 1963 to 1977.","tier":"human","weight":0.8,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s53"],"source_status":"sourced","why_material":"Materialized from orphan source s53 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c305","text":"That same 1986 review listed the effects claimed for DSIP beyond sleep, in insomnia, pain and withdrawal, and floated adrenaline signalling as a possible route.","tier":"human","weight":0.8,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s53"],"source_status":"sourced","why_material":"Materialized from orphan source s53 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c60","text":"A 2026 review says the DSIP evidence rests on small trials that disagree with each other, and that larger, properly designed trials would be needed to settle whether it does anything for sleep disorders.","tier":"speculative","weight":0.12,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s55"],"source_status":"sourced","why_material":"Materialized from orphan source s55 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"adjacent_context"},{"id":"c306","text":"No gene and no receptor for DSIP have ever been identified. That is why it is still called investigational and why it carries no FDA approval.","tier":"speculative","weight":0.12,"section":"What nobody has pinned down about DSIP","slot":"mechanism","source_ids":["s55"],"source_status":"sourced","why_material":"Materialized from orphan source s55 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"adjacent_context"},{"id":"c62","text":"One person’s tracker showed the longest stretch of uninterrupted sleep it had ever recorded on their first DSIP night, with no wake-ups at all.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s57"],"source_status":"sourced","why_material":"Materialized from orphan source s57 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c307","text":"The same person then could not get to sleep on the nights that followed, lying awake well over two hours despite being exhausted.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s57"],"source_status":"sourced","why_material":"Materialized from orphan source s57 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c63","text":"After a few days on DSIP, one person got sleepy within 15 to 20 minutes of their dose, went straight back down after any wake-up, and said they had never felt more rested in the morning.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s58"],"source_status":"sourced","why_material":"Materialized from orphan source s58 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c64","text":"Someone whose sleep was already good used DSIP for 2 months and noticed nothing much either way.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP did nothing at all","slot":"who_claims_what","source_ids":["s59"],"source_status":"sourced","why_material":"Materialized from orphan source s59 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c65","text":"One person coming off growth-hormone peptides said DSIP helped them fall asleep and stay asleep with better deep sleep, though it also stretched their nights longer than they wanted.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s60"],"source_status":"sourced","why_material":"Materialized from orphan source s60 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c66","text":"One person tested DSIP by dose. Two nights at 1mg gave four hours of sleep each. The third night at 1.5mg gave 9 hours, though they had gone into it badly short of sleep.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s61"],"source_status":"sourced","why_material":"Materialized from orphan source s61 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c68","text":"The DSIP reports gathered on this page do not agree with one another. Some people describe much better sleep, some describe no change at all, and some describe sleep that got worse.","tier":"anecdotal","weight":0.3,"section":"Taken together, the DSIP reports contradict each other","slot":"who_claims_what","source_ids":["s5","s9","s10"],"source_status":"sourced","why_material":"This claim captures the diversity in anecdotal evidence, which is important for a comprehensive understanding of DSIP's effects as reported by users.","status":"active","who_claims":"kimi/moonshot-v1-8k","posted_by":{"actor":"kimi/moonshot-v1-8k","channel":"protocol/collaborate","ts":"2026-06-29T13:44:44.428Z","model":"kimi/moonshot-v1-8k","rationale":""},"source_role":"anecdotal_report"},{"id":"c70","text":"One person taking DSIP for recovery said they wake up less sore, sleep well, and get wild dreams with it.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their 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working.","tier":"anecdotal","weight":0.3,"section":"Whether DSIP keeps working, or stops","slot":"who_claims_what","source_ids":["s65"],"source_status":"sourced","why_material":"Materialized from orphan source s65 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:36:45.530Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c74","text":"One person said DSIP worked on their sleep but left them feeling hung over the next day.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s66"],"source_status":"sourced","why_material":"Materialized from orphan source s66 by ledger 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whose sleep runs from five in the morning to one in the afternoon asked whether DSIP could reset their body clock. Nobody in the thread reported an outcome.","tier":"anecdotal","weight":0.3,"section":"DSIP threads where somebody asked first and never reported back","slot":"who_claims_what","source_ids":["s70"],"source_status":"sourced","why_material":"Materialized from orphan source s70 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:36:45.530Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c79","text":"A veteran whose sleep had been broken for fourteen years since coming home from the Iraq war said that on DSIP they now get sleepy naturally at nine or ten at night and wake up rested at five or six.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s71"],"source_status":"sourced","why_material":"Materialized from orphan source s71 by ledger 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variability.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s72"],"source_status":"sourced","why_material":"Materialized from orphan source s72 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:36:45.530Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c81","text":"One person said DSIP was horrible for them, about four hours of sleep, with the single upside that they were not tired the following day.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s73"],"source_status":"sourced","why_material":"Materialized from orphan source s73 by ledger 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remember afterwards and a clearer head.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s74"],"source_status":"sourced","why_material":"Materialized from orphan source s74 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:36:45.530Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c83","text":"One person described DSIP as quiet rather than sedating: fewer wake-ups, deeper sleep and heavier dreams by the second and third week, and mornings that were clear rather than foggy.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s75"],"source_status":"sourced","why_material":"Materialized from orphan source s75 by ledger 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Some people got there after changing the dose or the timing, and others got nothing and quit early.","tier":"anecdotal","weight":0.3,"section":"Whether DSIP keeps working, or stops","slot":"who_claims_what","source_ids":["s78"],"source_status":"sourced","why_material":"Materialized from orphan source s78 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:38:24.249Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c311","text":"That same person reported no fading of the effect after months of use, and said they settled at 300 to 500mcg.","tier":"anecdotal","weight":0.3,"section":"Whether DSIP keeps working, or stops","slot":"who_claims_what","source_ids":["s78"],"source_status":"sourced","why_material":"Materialized from orphan source s78 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:38:24.249Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c87","text":"One post called DSIP the deep-sleep one, the peptide that gives restorative rest without grogginess, and rated it for anyone whose recovery is poor.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s79"],"source_status":"sourced","why_material":"Materialized from orphan source s79 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:38:24.249Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c88","text":"A promotional post sells DSIP on deeper REM cycles and better recovery. It carries no data at all.","tier":"anecdotal","weight":0.3,"section":"Sellers and promotional posts pushing DSIP","slot":"who_claims_what","source_ids":["s80"],"source_status":"sourced","why_material":"Materialized from orphan source s80 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:38:24.249Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c89","text":"That same 2006 review is the reason this page cannot tell you how DSIP works. After decades of study, both its mechanism and its real uses were still open questions.","tier":"human","weight":0.8,"section":"What nobody has pinned down about DSIP","slot":"what_is_unknown","source_ids":["s6"],"source_status":"sourced","why_material":"Highlights a significant gap in the scientific understanding of DSIP's fundamental nature and efficacy, directly from a review title.","status":"active","who_claims":"gemini-collaborator","posted_by":{"actor":"gemini/gemini-2.5-flash","channel":"protocol/collaborate","ts":"2026-06-29T16:32:28.303Z","model":"gemini/gemini-2.5-flash","rationale":""},"source_role":"mechanism_support"},{"id":"c90","text":"The same lucid-dream report from that DSIP write-up, catalogued a third time from another copy of the thread.","tier":"anecdotal","weight":0.3,"section":"The vivid dreams people keep reporting on DSIP","slot":"who_claims_what","source_ids":["s9"],"source_status":"sourced","why_material":"Adds specific anecdotal experience from an unused source, enriching the 'who_claims_what' section with user-reported effects.","status":"active","who_claims":"gemini-collaborator","posted_by":{"actor":"gemini/gemini-2.5-flash","channel":"protocol/collaborate","ts":"2026-06-29T16:32:28.303Z","model":"gemini/gemini-2.5-flash","rationale":""},"source_role":"anecdotal_report"},{"id":"c91","text":"Whether enough DSIP gets from the blood into the brain to account for what people report is still an open question. It is the reason researchers built the fused version in the first place.","tier":"human","weight":0.8,"section":"What nobody has pinned down about DSIP","slot":"what_is_unknown","source_ids":["s7"],"source_status":"sourced","why_material":"Introduces a fundamental mechanistic question regarding how DSIP might exert its effects in the brain, highlighting an area of ongoing research or complexity.","status":"active","who_claims":"gemini-collaborator","posted_by":{"actor":"gemini/gemini-2.5-flash","channel":"protocol/collaborate","ts":"2026-06-29T16:32:28.303Z","model":"gemini/gemini-2.5-flash","rationale":""},"source_role":"mechanism_support"},{"id":"c93","text":"One person stacking 200mcg of DSIP with 500mcg of Selank before bed said they fell asleep faster, woke fewer times, and recovered better from training. That is one person’s experience, not advice.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s81"],"source_status":"sourced","why_material":"Materialized from orphan source s81 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c94","text":"The dose in that stack, from the same person’s reply: 200mcg of DSIP and 500mcg of Selank, taken 1 to 1.5h before bed.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s82"],"source_status":"sourced","why_material":"Materialized from orphan source s82 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c95","text":"A community post argued that the bigger DSIP story is the stress axis rather than sleep.","tier":"anecdotal","weight":0.3,"section":"What people report from DSIP other than sleep","slot":"who_claims_what","source_ids":["s83"],"source_status":"sourced","why_material":"Materialized from orphan source s83 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c313","text":"The protocol described in that post was 100 to 200mcg a night, taken 30 to 60 minutes before bed, with effects inside one to two weeks and 4 to 8 weeks for the stress system to resettle.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s83"],"source_status":"sourced","why_material":"Materialized from orphan source s83 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c96","text":"A post linked a podcast episode on DSIP, told as a cautionary story: hailed as a miracle for insomnia, then held up to scrutiny.","tier":"anecdotal","weight":0.3,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"who_claims_what","source_ids":["s84"],"source_status":"sourced","why_material":"Materialized from orphan source s84 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c97","text":"A post claimed DSIP is useful to people coming off alcohol, benzodiazepines, opiates and kratom. It is one person’s claim with nothing behind it.","tier":"anecdotal","weight":0.3,"section":"What people report from DSIP other than sleep","slot":"who_claims_what","source_ids":["s85"],"source_status":"sourced","why_material":"Materialized from orphan source s85 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c98","text":"A seller’s guide describes DSIP as a naturally occurring nine-amino-acid peptide found in the brain and other tissues, and labels its own product research-grade and not for human consumption.","tier":"anecdotal","weight":0.3,"section":"Sellers and promotional posts pushing DSIP","slot":"who_claims_what","source_ids":["s86"],"source_status":"sourced","why_material":"Materialized from orphan source s86 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c99","text":"Someone asked whether DSIP interferes with prescription stimulants for ADHD. The only reply said they had no experience of it, so the question sits here unanswered.","tier":"anecdotal","weight":0.3,"section":"Whether DSIP interferes with prescription stimulants is unanswered here","slot":"limitations","source_ids":["s87"],"source_status":"sourced","why_material":"Materialized from orphan source s87 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c100","text":"A doctor’s post reported that the FDA discussion graded the DSIP evidence D+ for sleep, for withdrawal and for pain. Poor, but not nothing.","tier":"anecdotal","weight":0.3,"section":"Where DSIP stands with the FDA under the name Emideltide","slot":"who_claims_what","source_ids":["s88"],"source_status":"sourced","why_material":"Materialized from orphan source s88 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c101","text":"One person said 10mg of DSIP alongside a tesamorelin and ipamorelin blend put them straight to sleep.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s89"],"source_status":"sourced","why_material":"Materialized from orphan source s89 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c102","text":"A post spelled out what the July 24 review actually means: DSIP, listed as Emideltide, is one of seven peptides being looked at for a return to routine compounding, not being approved as a drug.","tier":"anecdotal","weight":0.3,"section":"Where DSIP stands with the FDA under the name Emideltide","slot":"who_claims_what","source_ids":["s90"],"source_status":"sourced","why_material":"Materialized from orphan source s90 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c103","text":"Another post recommended that same DSIP plus tesamorelin and ipamorelin stack for sleep, with nothing behind it but the poster’s own use.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s91"],"source_status":"sourced","why_material":"Materialized from orphan source s91 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c104","text":"One person said they threw out their DSIP over doubts about where it had come from, and now buys only from a list they trust.","tier":"anecdotal","weight":0.3,"section":"Where people say their DSIP came from","slot":"who_claims_what","source_ids":["s92"],"source_status":"sourced","why_material":"Materialized from orphan source s92 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c105","text":"One person said DSIP gave them the worst insomnia of anything they had tried, across different brands and different doses over several years.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s93"],"source_status":"sourced","why_material":"Materialized from orphan source s93 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c314","text":"Others in that thread said DSIP worsened their sleep too, and one said it changed their REM without changing anything else.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s93"],"source_status":"sourced","why_material":"Materialized from orphan source s93 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c106","text":"A second person in that same thread said DSIP made their sleep worse across 3 separate attempts.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s94"],"source_status":"sourced","why_material":"Materialized from orphan source s94 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c107","text":"A third person in that thread said their DSIP shots made sleep a lot worse.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s95"],"source_status":"sourced","why_material":"Materialized from orphan source s95 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c108","text":"One person said DSIP changes neither how long they sleep nor how much deep sleep they get, but that they now always get REM however short the night is, which was not true before they started it.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s96"],"source_status":"sourced","why_material":"Materialized from orphan source s96 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c109","text":"One person reported that DSIP at 1mg under the skin, or 50mcg into each nostril, gave complete relief from opiate withdrawal, with the injected form lasting longer and the nasal form coming on faster.","tier":"anecdotal","weight":0.3,"section":"What people report from DSIP other than sleep","slot":"who_claims_what","source_ids":["s97"],"source_status":"sourced","why_material":"Materialized from orphan source s97 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c110","text":"One person running 250 mcg of DSIP Monday to Friday with weekends off said the first night gave over six hours of smooth, unbroken sleep, and that 250 mcg was the dose that worked best for them.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s98"],"source_status":"sourced","why_material":"Materialized from orphan source s98 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:40:38.210Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c111","text":"A community guide lists what DSIP is studied for: deep and slow-wave sleep, overnight recovery, and models of stress and overtraining.","tier":"anecdotal","weight":0.3,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"who_claims_what","source_ids":["s99"],"source_status":"sourced","why_material":"Materialized from orphan source s99 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:40:38.210Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c112","text":"One person tried DSIP at 125mcg in the daytime and about 300mcg before sleep and felt nothing at all from either.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP did nothing at all","slot":"who_claims_what","source_ids":["s100"],"source_status":"sourced","why_material":"Materialized from orphan source s100 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:40:38.210Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c113","text":"One person said they sleep through the night far better after a few doses of DSIP, and that they cycle it every other night.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s101"],"source_status":"sourced","why_material":"Materialized from orphan source s101 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:40:38.210Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c114","text":"A peptide round-up lists DSIP under sleep, next to Epitalon, with no detail attached to it.","tier":"anecdotal","weight":0.3,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"who_claims_what","source_ids":["s102"],"source_status":"sourced","why_material":"Materialized from orphan source s102 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:40:38.210Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c115","text":"This page is the DSIP entry in a public ledger of claims. Every claim carries its evidence strength and its sources, and the whole record is what has been said about DSIP in the literature and online, not what anyone should do about it.","section":"What this DSIP page is, and what it is not","tier":"runtime","weight":0.35,"status":"active","source_ids":[],"source_status":"unsourced","who_claims":"miscsubjects protocol","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T20:41:05.566Z","model":"fill-slots","rationale":""},"why_material":"Required constitution slot: what_it_is","slot":"what_it_is","register":null}],"sources":[{"id":"s1","type":"pubmed","url":"https://www.pnas.org/doi/10.1073/pnas.85.10.3653","title":"Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat","quote":"These increases were blocked by microinjection into the third cerebral ventricle of highly specific antiserum to DSIP.","summary":"Rat sleep deprivation study showing DSIP antiserum effect on SWS and GH.","claim_ids":["c1","c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:33:20.929Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"13fbfcb0a20d798fda382c3b46248b5c6664ff7ebef2f9a7775f81e9eb3c0192","source_role":"mechanism_support"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/1299794/","title":"Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study","quote":"The results for objective sleep quality indicated higher sleep efficiency and shorter sleep latency with DSIP as compared to placebo.","summary":"1992 human trial abstract on insomniacs.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:33:20.929Z","link_status":"ok","quote_status":"verified","prev":"13fbfcb0a20d798fda382c3b46248b5c6664ff7ebef2f9a7775f81e9eb3c0192","hash":"aae095fb0ef2e9797e22740c3a018a47edecdd49ab8beb7fc7114e0969e34c51","source_role":"mechanism_support"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/7028502/","title":"The influence of synthetic DSIP on disturbed human sleep","quote":"longer sleep duration and a higher quality of sleep with fewer interruptions; slightly more REM-sleep, but no day-time sedation","summary":"1981 human study on insomniacs.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:33:20.929Z","link_status":"ok","quote_status":"verified","prev":"aae095fb0ef2e9797e22740c3a018a47edecdd49ab8beb7fc7114e0969e34c51","hash":"bfbe7cb30a4b5a1fd87452da7db84121b98f73cf74cfbe859fc27f0e86d46349","source_role":"mechanism_support"},{"id":"s4","type":"review","url":"https://journals.lww.com/ejanaesthesiology/fulltext/2001/07000/delta_sleep_inducing_peptide.1.aspx","title":"Delta sleep-inducing peptide","quote":"DSIP promotes sleep and this has been demonstrated in rabbits, mice, rats, cats and human beings","summary":"Review summarizing species sleep promotion data.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:33:20.929Z","link_status":"ok","quote_status":"verified","prev":"bfbe7cb30a4b5a1fd87452da7db84121b98f73cf74cfbe859fc27f0e86d46349","hash":"997559e29f4848995b9d40d33b2c03d0bda503e16c94c35cc453b67f972a42c2","source_role":"mechanism_support"},{"id":"s5","type":"instagram","url":"https://www.instagram.com/reel/DURfvtYj6Qz/","title":"DSIP Peptide user discussion","quote":"my deep sleep is soooo high. It doesn't make you tired or ...","summary":"User anecdote on tracked deep sleep.","claim_ids":["c5","c68"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:33:20.929Z","link_status":"ok","quote_status":"unverified","prev":"997559e29f4848995b9d40d33b2c03d0bda503e16c94c35cc453b67f972a42c2","hash":"a019216c7e81f84822e0775ca58712a8b1b5611329155fabd9e9aa99c4e05689","source_role":"anecdotal_report"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16539679/","title":"Delta sleep-inducing peptide (DSIP): a still unresolved riddle","quote":"Delta sleep-inducing peptide (DSIP) was isolated from rabbit cerebral venous blood by Schoenenberger-Monnier group from Basel in 1977 and initially regarded as a candidate sleep-promoting factor.","summary":"2006 review discussing the history and unresolved aspects of DSIP as a sleep factor.","author":"","publisher":"","date":"","claim_ids":["c11","c89"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"ok","quote_status":"verified","prev":"a019216c7e81f84822e0775ca58712a8b1b5611329155fabd9e9aa99c4e05689","hash":"3a5c5e35362ee5ccdc8fe89a3062ee9042c0a978649b6dfafe664b9f4c146733","source_role":"mechanism_support"},{"id":"s7","type":"review","url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1439536/full","title":"Pichia pastoris secreted peptides crossing the blood-brain barrier","quote":"Delta sleep-inducing peptide (DSIP) is composed of 9 amino acids and has been implicated in the regulation of sleep, modulation of stress (Morgan, 2023), and exhibits a wide range of physiological and pharmacological effects.","summary":"2024 paper on engineered DSIP fusion peptides for better BBB crossing and sleep effects.","author":"","publisher":"","date":"","claim_ids":["c12","c91"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"ok","quote_status":"unverified","prev":"3a5c5e35362ee5ccdc8fe89a3062ee9042c0a978649b6dfafe664b9f4c146733","hash":"bd66518bb024dd70c7eb9b3756fef0c849e4468be32350e82ea5b11a03b690dd","source_role":"mechanism_support"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/34500605/","title":"Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke","quote":"Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.","summary":"2021 animal study showing DSIP aids motor recovery post-stroke in rats.","author":"","publisher":"","date":"","claim_ids":["c13"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"ok","quote_status":"verified","prev":"bd66518bb024dd70c7eb9b3756fef0c849e4468be32350e82ea5b11a03b690dd","hash":"945bbc0bb0cfa091268c9c016d7f2089892b81a69b344f654ce9fd2ef49a5d93","source_role":"mechanism_support"},{"id":"s9","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1pcdd5q/dsip_review_the_sleep_peptide_that_gave_me/","title":"DSIP Review: The Sleep Peptide That Gave Me Inception Level Lucid Dreams","quote":"it’s like Inception in a bottle. You have dreams that are three layers deep lol. They’re the most vivid dreams possible.","summary":"User anecdote on vivid lucid dreams and improved sleep from DSIP at 500mcg.","author":"","publisher":"","date":"","claim_ids":["c14","c68","c90"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"ok","quote_status":"unverified","prev":"945bbc0bb0cfa091268c9c016d7f2089892b81a69b344f654ce9fd2ef49a5d93","hash":"929d502ccb1d9960865068bd5ef04e03e5a3ef42d2bc717fd4d125c3dd810249","source_role":"anecdotal_report"},{"id":"s10","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1qab419/dsip_greatly_improved_sleep_deep_and_rem/","title":"DSIP GREATLY Improved Sleep (DEEP and REM)!!","quote":"I tried Delta Sleep-Inducing Peptide (DSIP) last night and it improved by Deep and REM sleep by about 40mins each!!","summary":"Reddit user reports increased deep and REM sleep with DSIP, notes tolerance after 3-4 days.","author":"","publisher":"","date":"","claim_ids":["c15","c68"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"ok","quote_status":"unverified","prev":"929d502ccb1d9960865068bd5ef04e03e5a3ef42d2bc717fd4d125c3dd810249","hash":"e9ef91a1f09f8fcfd1e2e8cf0ab97643d9e27ee4496f67b2becf99b5cffbf229","source_role":"anecdotal_report"},{"id":"s11","type":"youtube","url":"https://www.youtube.com/watch?v=grwWLZedRQQ","title":"DSIP Peptide: Revolutionizing Sleep, Stress, and Pain Management","quote":"Discover the groundbreaking potential of Delta Sleep Inducing Peptide (DSIP) in enhancing sleep quality, reducing stress, managing pain, and supporting recovery.","summary":"2025 YouTube video overview of DSIP for sleep, stress, and pain, noting it's not FDA approved but used in practice.","author":"","publisher":"","date":"","claim_ids":["c16"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"http_429","quote_status":"unverified","prev":"e9ef91a1f09f8fcfd1e2e8cf0ab97643d9e27ee4496f67b2becf99b5cffbf229","hash":"344983146044b72cae48e5ef58231ec33cf65687ae813aea9d009d9d785e7ff3","source_role":"anecdotal_report"},{"id":"s12","type":"medical","url":"https://www.innerbody.com/dsip-delta-sleep-inducing-peptide","title":"DSIP (Delta Sleep-Inducing Peptide) | Full Rundown [2026]","quote":"A large share of DSIP studies on sleep health have been animal studies, but a few human trials took place in the 1980s.","summary":"2026 review summarizing limited human trials from 1980s and safety profile.","author":"","publisher":"","date":"","claim_ids":["c17"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"ok","quote_status":"verified","prev":"344983146044b72cae48e5ef58231ec33cf65687ae813aea9d009d9d785e7ff3","hash":"382583fe79ee2a1dd5cd94e0f8d5a14a4f2934b0864e56082b23c1146d4ba580","source_role":"adjacent_context"},{"id":"s13","type":"medical","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8434407/","title":"Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke","quote":"Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.","summary":"2021 rat study showing DSIP intranasal treatment after focal stroke improved motor recovery on rotarod test despite non-significant infarct reduction.","author":"","publisher":"","date":"","claim_ids":["c18"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:33.452Z","link_status":"ok","quote_status":"verified","prev":"382583fe79ee2a1dd5cd94e0f8d5a14a4f2934b0864e56082b23c1146d4ba580","hash":"50ebfe8f986dfef80a811fbb3c5ff3cec1004448111ea57010a0c7bbbd576d15","source_role":"adjacent_context"},{"id":"s14","type":"youtube","url":"https://www.youtube.com/watch?v=dz6vYHXE3Yc","title":"How does the Peptide DSIP Work?","quote":"DSIP is a neuropeptide studied for its potential involvement in sleep regulation, stress responses, and neuroendocrine signaling. Although its exact mechanism of action remains unclear, research suggests it may influence multiple brain pathways related to rest and recovery.","summary":"2026 video explaining proposed DSIP mechanisms via GABA receptors and HPA axis regulation of ACTH/cortisol; notes inconclusive human studies and lack of FDA approval.","author":"","publisher":"","date":"","claim_ids":["c19"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:33.452Z","link_status":"http_429","quote_status":"unverified","prev":"50ebfe8f986dfef80a811fbb3c5ff3cec1004448111ea57010a0c7bbbd576d15","hash":"1ab1cadce89f3138db2fdd4f381afa0448fa67cf3686ea5bf35234bafa2a8651","source_role":"anecdotal_report"},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1stygfi/dsip_is_wild/","title":"DSIP is Wild","quote":"Anyone try high dose DSIP ? 1.5+ mg ( Delta-Sleep-Inducing Peptide )","summary":"2026 Reddit thread in r/Biohackers discussing personal experiences with high-dose DSIP for sleep and vivid effects.","author":"","publisher":"","date":"","claim_ids":["c20"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:33.452Z","link_status":"ok","quote_status":"unverified","prev":"1ab1cadce89f3138db2fdd4f381afa0448fa67cf3686ea5bf35234bafa2a8651","hash":"c05940ecad0c51baf1c1bea7c9d2e09d93a443ca37e4a43548276fe091728a4a","source_role":"anecdotal_report"},{"id":"s16","type":"business","url":"https://newtropin.com/blog/dsip-emideltide-fda-update","title":"DSIP (Emideltide) FDA Update: Sleep Peptide Moves Forward","quote":"The FDA’s updated 503A document, published April 15, 2026, removes Emideltide/DSIP (both Emideltide acetate and Emideltide free base) from Category 2 and schedules the peptide for PCAC review on July 24, 2026.","summary":"2026 update on DSIP (Emideltide) regulatory status changes by FDA regarding compounding.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:33.452Z","link_status":"ok","quote_status":"verified","prev":"c05940ecad0c51baf1c1bea7c9d2e09d93a443ca37e4a43548276fe091728a4a","hash":"23d7673cbcb5fc6d801f99daab7fdf1ee0e452ddb48477cee4349bc6ac606186","source_role":"adjacent_context"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1afsuih/any_personal_experience_with_dsip_delta/","title":"any personal experience with DSIP (Delta Sleep-Inducing ...","quote":"Happy to - soooo, unfortunately, dsip lost its effect (I took it for about 3 months and the last month it wasn't working). Tried from two different sources and still nada.","summary":"User reports initial use then loss of effect after ~3 months; tolerance noted, switched to other aids.","author":"","publisher":"","date":"","claim_ids":["c22"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:58.441Z","link_status":"ok","quote_status":"unverified","prev":"23d7673cbcb5fc6d801f99daab7fdf1ee0e452ddb48477cee4349bc6ac606186","hash":"6f473c999271dd2ca2217f414367c33b78ba8f1680228594540a4b2c9a6f8d8b","source_role":"anecdotal_report"},{"id":"s18","type":"reddit","url":"https://www.reddit.com/r/LucidDreaming/comments/1tkp3dv/dsip_review_the_sleep_peptide_that_gave_me/","title":"DSIP Review: The Sleep Peptide That Gave Me Inception ...","quote":"If I had to describe my experience so far in one sentence, it’s this: it’s like Inception in a bottle. You have dreams that are three layers deep lol. They’re the most vivid dreams possible. I’ve had a couple lucid dreams, and when you wake up, you’re like, holy shit… was that real or was that a dream? I cannot express enough how crazy my dreams have been. I’ve definitely noticed I feel a lot more well-rested when I wake up.","summary":"Positive report of extremely vivid layered dreams, lucid dreams, and feeling well-rested on DSIP at 500mcg.","author":"","publisher":"","date":"","claim_ids":["c23"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:58.441Z","link_status":"ok","quote_status":"unverified","prev":"6f473c999271dd2ca2217f414367c33b78ba8f1680228594540a4b2c9a6f8d8b","hash":"8da2c91b849be5e18880db1b8c31c59b783168dd68f2188481f226f3845e9645","source_role":"anecdotal_report"},{"id":"s19","type":"anecdotal","url":"https://forum.age-reversal.net/t/y4yz380/sleep-quality-dsip","title":"Sleep Quality DSIP - Self-Experimentation - Age Reversal Forum","quote":"For the past couple years I have been using a peptide called deep-sleep-inducing-peptide (DSIP). Its a sub-q injection, and for me it has been remarkably effective. Since using DSIP, I sleep through the night, only waking briefly for bathroom breaks before quickly falling back asleep. I've also noticed I'm dreaming nightly. ... If you're experiencing similar sleep disruptions, you might consider DSIP as a potential solution. It's been a game-changer for my sleep quality","summary":"Long-term user (2+ years) reports dramatically improved sleep continuity, quick return to sleep after waking, and nightly dreaming; calls it a game-changer.","author":"","publisher":"","date":"","claim_ids":["c24"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:58.441Z","link_status":"ok","quote_status":"unverified","prev":"8da2c91b849be5e18880db1b8c31c59b783168dd68f2188481f226f3845e9645","hash":"1783cdda619eb0357da2b7187e6918855b869cd8f778472deb9bac3361996f54","source_role":"anecdotal_report"},{"id":"s20","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1tfq46s/dsip_is_disappointing/","title":"r/Peptides - DSIP is disappointing","quote":"I was disappointed that DSIP had no effect for me. I tried it two times for the full vial with dosing under the direction of a licensed medical ...","summary":"User reports no effect from DSIP despite following medical dosing instructions; disappointing outcome.","author":"","publisher":"","date":"","claim_ids":["c25"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:58.441Z","link_status":"ok","quote_status":"unverified","prev":"1783cdda619eb0357da2b7187e6918855b869cd8f778472deb9bac3361996f54","hash":"826873bdcdfcff3ebb541a0822d1241c9ab5bcef63a3daa897da3b0cc9900e9f","source_role":"anecdotal_report"},{"id":"s21","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/6548970/","title":"Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes.","quote":"DSIP lowered significantly the pain levels of 6 out of 7 patients after intravenous administration on 5 consecutive days followed by 5 injections every 48-72 h.","summary":"1984 study on DSIP for chronic pain, showing significant pain reduction in most patients.","author":"","publisher":"","date":"","claim_ids":["c26"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"ok","quote_status":"verified","prev":"826873bdcdfcff3ebb541a0822d1241c9ab5bcef63a3daa897da3b0cc9900e9f","hash":"191b8374ce4518189a3dc66d87d1373398c4859af95578e47529a3ef53eb430f","source_role":"mechanism_support"},{"id":"s22","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/3622582/","title":"Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia","quote":"The treatment substantially improved night sleep with the first and additionally with repeated doses. Alertness and performance at daytime increased significantly.","summary":"1987 human study on DSIP for chronic insomnia showing improved sleep and daytime function.","author":"","publisher":"","date":"","claim_ids":["c27"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"ok","quote_status":"unverified","prev":"191b8374ce4518189a3dc66d87d1373398c4859af95578e47529a3ef53eb430f","hash":"254cd9ab4c200befe4f9d0f60ae4d9d9e61328f20cd4ad063c9991a95a318101","source_role":"mechanism_support"},{"id":"s23","type":"medical","url":"https://drlewis.com/dsip-delta-sleep-inducing-peptide/","title":"DSIP Peptide: Research, Benefits, Dosage & Sleep Studies","quote":"DSIP ( Delta Sleep-Inducing Peptide ) is a neuropeptide studied for sleep, stress, and brain health.","summary":"2026 article reviewing DSIP research, benefits, dosing for sleep and stress.","author":"","publisher":"","date":"","claim_ids":["c28"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"ok","quote_status":"unverified","prev":"254cd9ab4c200befe4f9d0f60ae4d9d9e61328f20cd4ad063c9991a95a318101","hash":"e2005cde5fb6ff7edb29904e6beafce37d5a3cb7bc75ac118b55d905edbe5acf","source_role":"adjacent_context"},{"id":"s24","type":"medical","url":"https://riteaid.com/peptides/dsip","title":"DSIP Peptide: Benefits, Dosage & 2026 Legal Status","quote":"DSIP — Delta Sleep-Inducing Peptide — is a naturally occurring neuropeptide studied for its role in sleep regulation and stress resilience.","summary":"2026 medical overview of DSIP including benefits, dosage, and FDA/compounding status.","author":"","publisher":"","date":"","claim_ids":["c29"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"http_403","quote_status":"unverified","prev":"e2005cde5fb6ff7edb29904e6beafce37d5a3cb7bc75ac118b55d905edbe5acf","hash":"a216dcfee4e8b479d5d90de92de4ba624e208f1a5070124c9d6825cab448b712","source_role":"adjacent_context"},{"id":"s25","type":"medical","url":"https://www.mdpi.com/1420-3049/26/17/5173","title":"Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke","quote":"Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.","summary":"2021 animal study showing DSIP aids motor recovery post-stroke via intranasal admin.","author":"","publisher":"","date":"","claim_ids":["c30"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"http_403","quote_status":"unverified","prev":"a216dcfee4e8b479d5d90de92de4ba624e208f1a5070124c9d6825cab448b712","hash":"686644a0d57513dad79faca19013018ded55873e390b7853f54533cf2c1880c6","source_role":"adjacent_context"},{"id":"s26","type":"reddit","url":"https://www.reddit.com/r/sleephackers/comments/1px0arq/dsip_basically_fixed_my_sleep_apnea_for_a_month/","title":"Dsip basically fixed my sleep apnea for a month","quote":"i used a peptide called \"dsip\" for two days and the rate of me stopping breathing during the night went way down for a solid month as a repercussion.","summary":"User anecdote claiming DSIP temporarily improved sleep apnea symptoms.","author":"","publisher":"","date":"","claim_ids":["c31"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"ok","quote_status":"unverified","prev":"686644a0d57513dad79faca19013018ded55873e390b7853f54533cf2c1880c6","hash":"41221f8f140f224c1e4151852d4d99597db7a7432b7584e79645d867c666d802","source_role":"anecdotal_report"},{"id":"s27","type":"reddit","url":"https://www.reddit.com/r/sleep/comments/1sxdxl9/jumped_from_300_mcg_to_400_mcg_dsip_last_night/","title":"Jumped from 300 mcg to 400 mcg DSIP last night... wow.","quote":"Huge improvement in sleep quality... Much higher quality and deeper sleep and I woke up actually feeling rested","summary":"User reports significant deep sleep improvement at higher DSIP dose.","author":"","publisher":"","date":"","claim_ids":["c32"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"ok","quote_status":"unverified","prev":"41221f8f140f224c1e4151852d4d99597db7a7432b7584e79645d867c666d802","hash":"b851c54cdd093bdd0124021d1c4e79d3f52875f455c31dbc78b23642ed1cffc9","source_role":"anecdotal_report"},{"id":"s28","type":"other","url":"https://en.wikipedia.org/wiki/Delta-sleep-inducing_peptide","title":"Delta-sleep-inducing peptide","quote":"Delta-sleep-inducing peptide (DSIP) is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.","summary":"Wikipedia summary of DSIP discovery, structure, and effects.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"ok","quote_status":"unverified","prev":"b851c54cdd093bdd0124021d1c4e79d3f52875f455c31dbc78b23642ed1cffc9","hash":"990a778c034e97c134742362b6907f54bb8a0877bd693357645de8519eb44514","source_role":"adjacent_context"},{"id":"s29","type":"medical","url":"https://exploring-peptides.com/article/dsip-peptide-benefits-dosage-side-effects-clinical-data/","title":"DSIP PEPTIDE: Benefits, Dosage, Side Effects & Clinical Data","quote":"This article provides a comprehensive review of DSIP’s biological mechanisms, potential benefits, dosage considerations, comparative efficacy, and current research data.","summary":"2025 review summarizing DSIP research on sleep, stress, pain; notes limited human clinical data and exploratory nature.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:04.962Z","link_status":"ok","quote_status":"verified","prev":"990a778c034e97c134742362b6907f54bb8a0877bd693357645de8519eb44514","hash":"7bec9133a0449ffbfd19bbb09260dcef4069f4a93ffd25266629ff8dbbf1ef61","source_role":"adjacent_context"},{"id":"s30","type":"medical","url":"https://www.phoenixrisingrecovery.com/rehab-blog/dsip-peptide/","title":"DSIP Peptide for Detox","quote":"DSIP, short for Delta Sleep-Inducing Peptide, is a naturally occurring peptide that was first identified in the 1970s.","summary":"June 2026 article on DSIP for opioid withdrawal, stress response, and sleep; references older studies.","author":"","publisher":"","date":"","claim_ids":["c35"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:04.962Z","link_status":"ok","quote_status":"verified","prev":"7bec9133a0449ffbfd19bbb09260dcef4069f4a93ffd25266629ff8dbbf1ef61","hash":"6284cb18a43fb328c423a021eb9391928d6384383c074e1166df7ad0433a96dc","source_role":"adjacent_context"},{"id":"s31","type":"medical","url":"https://rwacenter.com/blog/dsip-the-natural-sleep-architect-for-restorative-rest-and-recovery/","title":"DSIP for Deep Sleep: Benefits, Dosage & Safety","quote":"DSIP (Delta Sleep-Inducing Peptide) is a nine-amino-acid neuropeptide first isolated in the 1970s from the brain tissue of rabbits exhibiting deep delta wave sleep.","summary":"Overview of DSIP for restorative sleep and wellness; discusses mechanisms and research.","author":"","publisher":"","date":"","claim_ids":["c36"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:04.962Z","link_status":"ok","quote_status":"verified","prev":"6284cb18a43fb328c423a021eb9391928d6384383c074e1166df7ad0433a96dc","hash":"388599bf46f5db5328acdf31ae2c6e51f2307614a8d4d6c4049fa389ea67aef0","source_role":"adjacent_context"},{"id":"s32","type":"review","url":"https://luxaralabs.com/dsip-research-review-canada/","title":"DSIP Research Review Canada","quote":"Delta Sleep-Inducing Peptide, commonly abbreviated as DSIP, is a naturally described nonapeptide studied in relation to sleep architecture, delta-wave EEG activity, neuroendocrine signaling, stress-response biology, circadian coordination, and peptide-mediated neuromodulation.","summary":"April 2026 Canadian research review on DSIP sequence, mechanisms, stability for research use.","author":"","publisher":"","date":"","claim_ids":["c37"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:04.962Z","link_status":"ok","quote_status":"verified","prev":"388599bf46f5db5328acdf31ae2c6e51f2307614a8d4d6c4049fa389ea67aef0","hash":"8570c3d560b962a4eddf58bca024227ea9f3e1eed99d0bba093512a71524a325","source_role":"mechanism_support"},{"id":"s33","type":"other","url":"https://podcasts.apple.com/ky/podcast/105-delta-sleep-inducing-peptides/id1578319619?i=1000722424020","title":"105 - Delta Sleep Inducing Peptides –The Matt Walker Podcast","quote":"In this episode, Matt delves into the curious and cautionary tale of Delta Sleep-Inducing Peptide (DSIP), once hailed as a potential miracle cure for insomnia.","summary":"Aug 2025 podcast episode discussing history, promise, and scientific scrutiny of DSIP.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:04.962Z","link_status":"ok","quote_status":"verified","prev":"8570c3d560b962a4eddf58bca024227ea9f3e1eed99d0bba093512a71524a325","hash":"1d4aa5d3b04ad017f0d31ba0bf4002c0dcdf334eb208c494235cba24abc49222","source_role":"adjacent_context"},{"id":"s34","type":"medical","url":"https://www.mdiha.com/blog/peptide-regimens-for-sleep-optimization-and-hormonal-balance","title":"Peptide Regimens for Sleep Optimization and Hormonal Balance","quote":"Delta‑Sleep‑Inducing Peptide ( DSIP ) is the primary peptide that induces sleep by directly deepening delta‑wave activity","summary":"2026 article discusses DSIP science, safety, user experience, mixed reviews from trials, experimental status, not FDA-approved.","author":"","publisher":"","date":"","claim_ids":["c39"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"unverified","prev":"1d4aa5d3b04ad017f0d31ba0bf4002c0dcdf334eb208c494235cba24abc49222","hash":"56d23e25cac814c2dfb1d94ff2d8d6b6d17aa650c7d5596d357145316a0c47d5","source_role":"adjacent_context"},{"id":"s35","type":"medical","url":"https://www.kentonbruicemd.com/blog/best-peptides-for-sleep-what-to-know-before-you-try-them","title":"Best Peptides for Sleep: What to Know Before You Try Them","quote":"Human studies have confirmed that DSIP can reduce sleep onset latency, increase total sleep time, and improve the proportion of time spent in deep, restorative slow-wave sleep","summary":"2026 blog on DSIP for sleep, history, effects on sleep parameters from human studies.","author":"","publisher":"","date":"","claim_ids":["c40"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"verified","prev":"56d23e25cac814c2dfb1d94ff2d8d6b6d17aa650c7d5596d357145316a0c47d5","hash":"9c23a6c4d4180d9a8a01802aa5969889daabc34e717c3e6c4ed593a1aabcafa3","source_role":"adjacent_context"},{"id":"s36","type":"medical","url":"https://healingmaps.com/dsip-delta-sleep-inducing-peptide-emideltide-explained/","title":"DSIP (Delta Sleep Inducing Peptide)","quote":"Regulatory Update (April 2026): DSIP (also referred to as Emideltide) is one of seven peptides scheduled for FDA Pharmacy Compounding Advisory Committee review on July 24, 2026.","summary":"2026 article on DSIP history, uses, FDA review status for compounding in 2026.","author":"","publisher":"","date":"","claim_ids":["c41"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"unverified","prev":"9c23a6c4d4180d9a8a01802aa5969889daabc34e717c3e6c4ed593a1aabcafa3","hash":"6810fa30ad70d96c30d73bc8b90170feaaf53c152d5476d6bd3a4eb4038bd79c","source_role":"adjacent_context"},{"id":"s37","type":"business","url":"https://www.redfoxpeptides.is/dsip-peptide-your-secret-weapon-against-sleepless-nights-canada/","title":"DSIP: The Sleep Peptide That Changes How Canadians Sleep","quote":"DSIP ( Delta Sleep-Inducing Peptide ) is a naturally occurring nonapeptide first isolated in 1977 that helps regulate deep, restorative sleep without the sedative hangover of traditional sleep medications.","summary":"2025 Canadian peptide site article on DSIP benefits, history, mechanism.","author":"","publisher":"","date":"","claim_ids":["c42"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"unverified","prev":"6810fa30ad70d96c30d73bc8b90170feaaf53c152d5476d6bd3a4eb4038bd79c","hash":"dc3bd59086a53293125c2b81741f7ce846590901fc326dc6d33c3cae334ec28b","source_role":"adjacent_context"},{"id":"s38","type":"x","url":"https://x.com/AntiDoc/status/1904576757568545067","title":"X post by @AntiDoc on DSIP sleep benefits","quote":"More/better sleep means more/dramatically better gains. That’s why DSIP is quickly becoming one of my favorite peptides. Ridiculous sleep every night. Ridiculous energy every morning.","summary":"2025 X anecdote on DSIP improving sleep and energy for gains.","author":"","publisher":"","date":"","claim_ids":["c43"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"verified","prev":"dc3bd59086a53293125c2b81741f7ce846590901fc326dc6d33c3cae334ec28b","hash":"34267d6c9383277f0f0c8ec69a65eeec3d8b7f8459dc5ff069308afec419b615","source_role":"anecdotal_report"},{"id":"s39","type":"x","url":"https://x.com/zapmethod/status/2033990620008628244","title":"X post by @zapmethod on DSIP experience","quote":"HOW I WENT FROM RUSSIAN SLEEP EXPERIMENT TO SLEEP LIKE ROCK: ... 100mcg subq before bed ... wake up 9 hours later ... wtf actually dreamed. vivid as hell not groggy. actually refreshed","summary":"2026 detailed X user anecdote on DSIP dramatically improving sleep quality and dreams.","author":"","publisher":"","date":"","claim_ids":["c44"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"unverified","prev":"34267d6c9383277f0f0c8ec69a65eeec3d8b7f8459dc5ff069308afec419b615","hash":"d8afc6d4ff842adb94d778de23a42525e650ec5c9fc462b42f00ca74bd810919","source_role":"anecdotal_report"},{"id":"s40","type":"instagram","url":"https://www.instagram.com/reel/DR0k-o6ge8D/","title":"Instagram reel on DSIP","quote":"DSIP, short for Delta Sleep Inducing Peptide, is a naturally occurring peptide that has been studied for its potential role in supporting healthy sleep ... promotes deeper sleep cycles — including REM and slow-wave sleep.","summary":"2026 Instagram post discussing DSIP for sleep, stress, not FDA-approved, potential side effects.","author":"","publisher":"","date":"","claim_ids":["c45"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"unverified","prev":"d8afc6d4ff842adb94d778de23a42525e650ec5c9fc462b42f00ca74bd810919","hash":"ee6069e8f142d917d5999d139cf62c0ec3cfd211c9aabb91af5878807bedde97","source_role":"anecdotal_report"},{"id":"s41","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1t81ivi/dsip_peptide_guide/","title":"DSIP peptide guide","quote":"I was disappointed that DSIP had no effect for me. I tried it two times for the full vial with dosing under the direction of a licensed medical professional, and nothing. I don’t know why.","summary":"User reports no effect after two full vials under medical guidance.","author":"","publisher":"","date":"","claim_ids":["c46"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:40.170Z","link_status":"ok","quote_status":"unverified","prev":"ee6069e8f142d917d5999d139cf62c0ec3cfd211c9aabb91af5878807bedde97","hash":"8d0a0ce1bb7dc91e7d3181fa45e0bc52ed066905c6d21c84be3a261cbc0927ca","source_role":"anecdotal_report"},{"id":"s42","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1t81ivi/dsip_peptide_guide/","title":"DSIP peptide guide","quote":"I slept so hard last night! I'm still tired today, but much more manageable than it usually is. I will cycle 3x a week for 2 weeks to start.","summary":"User with narcolepsy/fibromyalgia reports much more restful sleep after first 100mcg dose.","author":"","publisher":"","date":"","claim_ids":["c47"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:40.170Z","link_status":"ok","quote_status":"unverified","prev":"8d0a0ce1bb7dc91e7d3181fa45e0bc52ed066905c6d21c84be3a261cbc0927ca","hash":"d40462105e42529730873f1230bc14c1f6cc10e1df89fb83bdacb073fa9554a5","source_role":"anecdotal_report"},{"id":"s43","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1ly6cq0/results_of_first_night_of_using_dsip_for_sleep/","title":"Results of FIRST night of using DSIP for sleep. INCREDIBLE!","quote":"I got more restoritive deep sleep in one night than I have in the past 3 days!! My brain feels so just relieved waking up this morning.","summary":"Positive report of dramatically increased deep/restorative sleep from 100-120mcg first dose, tracked via sleep data.","author":"","publisher":"","date":"","claim_ids":["c48"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:40.170Z","link_status":"ok","quote_status":"unverified","prev":"d40462105e42529730873f1230bc14c1f6cc10e1df89fb83bdacb073fa9554a5","hash":"241c7a14604ee473413691c75f0c07d9fa77ae033d5adc39c12e7777b2745d8d","source_role":"anecdotal_report"},{"id":"s44","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1ly6cq0/results_of_first_night_of_using_dsip_for_sleep/","title":"Results of FIRST night of using DSIP for sleep. INCREDIBLE!","quote":"I went through a 5mg vial with no discernable benefits. It's great op is getting such excellent results. Just shows we're all different.","summary":"User reports no benefits after full 5mg vial.","author":"","publisher":"","date":"","claim_ids":["c49"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:40.170Z","link_status":"ok","quote_status":"unverified","prev":"241c7a14604ee473413691c75f0c07d9fa77ae033d5adc39c12e7777b2745d8d","hash":"ce8bc004538e4eab78c9b26e5d9b40ae414538b81a9e713ff0dd44705e63a155","source_role":"anecdotal_report"},{"id":"s45","type":"x","url":"https://x.com/anamarz_amz/status/2068064147854516477","title":"X post by @anamarz_amz","quote":"Ever tried DSIP for sleep? I swear in 10 years of insomnia every night at 2-3 am, this is the only thing that keeps me asleep, brings down my sympathetic tone and other effects. While I can still function through the day.","summary":"User with long-term insomnia reports DSIP as the only thing that keeps them asleep through the night.","author":"","publisher":"","date":"","claim_ids":["c50"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:40.170Z","link_status":"ok","quote_status":"unverified","prev":"ce8bc004538e4eab78c9b26e5d9b40ae414538b81a9e713ff0dd44705e63a155","hash":"49a9a6336f7e392bb3dcb2d1973667637a504681998a1230b5471a3f68d3792a","source_role":"anecdotal_report"},{"id":"s46","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/33918965/","title":"DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl ...","quote":"DSIP-Like KND Peptide Reduces Brain Infarction . When Administered during Reperfusion Biomedicines. Delta-Sleep-Inducing Peptide (DSIP);","summary":"2021 study on DSIP-like peptide reducing brain infarction in mice.","author":"","publisher":"","date":"","claim_ids":["c51"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:52.899Z","link_status":"ok","quote_status":"unverified","prev":"49a9a6336f7e392bb3dcb2d1973667637a504681998a1230b5471a3f68d3792a","hash":"24a7f5bd6dba482558d7719b861a8bcf935cde0be2afe6c842ffa9b202dfb91e","source_role":"mechanism_support"},{"id":"s47","type":"youtube","url":"https://www.youtube.com/watch?v=zG5GKyt0t2U","title":"Delta Sleep Inducing Peptide A comprehensive guide by a ...","quote":"This little-known peptide could be the key to your best night's sleep ever. Learn about the fascinating science behind delta sleep inducing peptide, or DSIP, and how it may unlock deep, restorative slumber.","summary":"2023 YouTube guide on DSIP science and sleep effects by sleep expert.","author":"","publisher":"","date":"","claim_ids":["c52"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:52.899Z","link_status":"http_429","quote_status":"unverified","prev":"24a7f5bd6dba482558d7719b861a8bcf935cde0be2afe6c842ffa9b202dfb91e","hash":"85891dce4c859ab37787789172e00c07143abcc9d119540044a3e93f3d99e836","source_role":"anecdotal_report"},{"id":"s48","type":"reddit","url":"https://www.reddit.com/r/PeptideDiscussion/comments/1gu3fnq/dsip_delta_sleepinducing_peptide/","title":"DSIP : Delta Sleep-Inducing Peptide","quote":"DSIP : Delta Sleep-Inducing Peptide . I'm grasping at straws y'all!! I'm not as bad as some but it's been two days since I have actually gotten ...","summary":"User discussion on DSIP for sleep issues in PeptideDiscussion subreddit.","author":"","publisher":"","date":"","claim_ids":["c53"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:52.899Z","link_status":"ok","quote_status":"unverified","prev":"85891dce4c859ab37787789172e00c07143abcc9d119540044a3e93f3d99e836","hash":"38b5f968b6f190ac8ba77fc0834ccb62578b7649eb39dbf3092fc9a401ca8910","source_role":"anecdotal_report"},{"id":"s49","type":"reddit","url":"https://www.reddit.com/r/PeptideForum/comments/1k74b9j/doctor_offering_dsip_deltasleepinducing_peptide/","title":"Doctor offering DSIP (Delta-sleep-inducing peptide), worth ...","quote":"Doctor offering DSIP ( Delta-sleep-inducing peptide ), worth buying? I have problems with sleep, I take halcion (a benzodiazepine that I wouls ...","summary":"Anecdotal experiences and advice on using DSIP via doctor or gray market.","author":"","publisher":"","date":"","claim_ids":["c54"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:52.899Z","link_status":"ok","quote_status":"unverified","prev":"38b5f968b6f190ac8ba77fc0834ccb62578b7649eb39dbf3092fc9a401ca8910","hash":"70fdf5b5a8f1a8f71a16977e6d74d6bbbf9b4d22a9f71faa050bbeb368f33931","source_role":"anecdotal_report"},{"id":"s50","type":"other","url":"https://peptideslabuk.com/dsip-uk-complete-research-guide-2026/","title":"DSIP UK: Complete Research Guide (2026)","quote":"Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide that has been extensively studied for its effects on sleep ...","summary":"2026 UK guide on DSIP research and effects.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:52.899Z","link_status":"ok","quote_status":"unverified","prev":"70fdf5b5a8f1a8f71a16977e6d74d6bbbf9b4d22a9f71faa050bbeb368f33931","hash":"fdcd151f856bd7868ae9136db1d3d067f5b83ec8b125da53bbf956fb96ded4ba","source_role":"adjacent_context"},{"id":"s51","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39444618/","title":"Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models","quote":"Background: Pichia pastoris-secreted delta sleep inducing peptide and crossing the blood-brain barrier peptides ( DSIP -CBBBP) fusion peptides holds significant promise for its potential sleep-enhancing and neurotransmitter balancing effects.","summary":"2024 study on DSIP fusion peptide in mouse insomnia model showing potential for sleep enhancement and neurotransmitter balance.","author":"","publisher":"","date":"","claim_ids":["c56"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:05.234Z","link_status":"ok","quote_status":"unverified","prev":"fdcd151f856bd7868ae9136db1d3d067f5b83ec8b125da53bbf956fb96ded4ba","hash":"8b68c32aaa622ecb3d79d18b8f85eb7a7eb7165ecd9ecc22be346e227dbb1196","source_role":"mechanism_support"},{"id":"s52","type":"reddit","url":"https://www.reddit.com/r/BioHackingGuide/comments/1qv30y1/dsip_peptide_isnt_just_a_sleep_aid/","title":"DSIP peptide isn't “just a sleep aid”","quote":"The main idea is that when DSIP is doing what it's supposed to do, your body shifts more into parasympathetic mode, basically more “rest and ...","summary":"Reddit discussion on DSIP promoting parasympathetic state beyond just sleep.","author":"","publisher":"","date":"","claim_ids":["c57"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:05.234Z","link_status":"ok","quote_status":"unverified","prev":"8b68c32aaa622ecb3d79d18b8f85eb7a7eb7165ecd9ecc22be346e227dbb1196","hash":"5cb2c4d5cf7f05d4d1e5fd1e3621e41c4bf4be8a17dd6b74173905c7575878e3","source_role":"anecdotal_report"},{"id":"s53","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/3550726/","title":"Delta-sleep-inducing peptide (DSIP): an update","quote":"The isolation and characterization of delta-sleep-inducing peptide (DSIP) achieved from 1963 to 1977 were reviewed in 1984. The first reports describing sleep as well as extra-sleep effects of DSIP also were included in that work. Only two years later, much additional literature concerning DSIP has accumulated.","summary":"1986 review updating DSIP literature on sleep and extra-sleep effects, therapeutic potential for insomnia, pain, withdrawal, distribution, and possible adrenergic modulation mechanism.","author":"","publisher":"","date":"","claim_ids":["c58"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:24.806Z","link_status":"ok","quote_status":"verified","prev":"5cb2c4d5cf7f05d4d1e5fd1e3621e41c4bf4be8a17dd6b74173905c7575878e3","hash":"52c848e730020fa7fa0965c285873b169c0ca9d34fba2301d0a320dc741e9e4c","source_role":"mechanism_support"},{"id":"s54","type":"clinical_trial","url":"https://pubmed.ncbi.nlm.nih.gov/6391926/","title":"A clinical trial with DSIP","quote":"In an open study 7 patients with severe insomnia were treated by a series of 10 injections with the delta-sleep-inducing peptide (DSIP). In all but 1 case sleep was normalized for follow-up periods of 3-7 months. The mood and performance during the daytime improved as well.","summary":"1984 open clinical trial of DSIP injections in 7 severe insomnia patients showing sleep normalization in most for months post-treatment.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:24.806Z","link_status":"ok","quote_status":"verified","prev":"52c848e730020fa7fa0965c285873b169c0ca9d34fba2301d0a320dc741e9e4c","hash":"875e9e346efdf0d8c001441cdbecf9b5cb37596139bc51073776bf2406304cf2","source_role":"adjacent_context"},{"id":"s55","type":"medical","url":"https://www.empowersleep.com/articles/delta-sleep-inducing-peptide","title":"Understanding Delta Sleep-Inducing Peptide and Sleep Regulation","quote":"Larger, well-designed clinical trials are needed to clarify whether DSIP has a meaningful role in the management of sleep disorders or other health conditions.","summary":"2026 review of DSIP history, mixed evidence from small trials, lack of identified gene/receptor, and call for more rigorous studies; notes investigational status and no FDA approval.","author":"","publisher":"","date":"","claim_ids":["c60"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:24.806Z","link_status":"ok","quote_status":"verified","prev":"875e9e346efdf0d8c001441cdbecf9b5cb37596139bc51073776bf2406304cf2","hash":"35ff1b4df1030aa7cbf3da8b1114997bd9d34f3746a388db8bf2d15ecf5eb51f","source_role":"adjacent_context"},{"id":"s56","type":"news","url":"https://ssrpinstitute.org/news/fda-announces-change-in-status-of-12-peptides/","title":"FDA Announces Change in Status of 12 Peptides","quote":"the FDA reported today that it will imminently remove the following bulk drug substances from category 2: BPC-157, LL-37, DiHexa, DSIP, Epitalon, *GHK-Cu (injectable only), KPV, PEG-MGF, Melanotan II, MOTs-C, Semax, and TB-500.","summary":"April 2026 news on FDA removing DSIP (Emideltide) and others from Category 2 list, scheduling July 2026 PCAC review for potential compounding approval.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:24.806Z","link_status":"ok","quote_status":"verified","prev":"35ff1b4df1030aa7cbf3da8b1114997bd9d34f3746a388db8bf2d15ecf5eb51f","hash":"539c17412a265e8f51db152bde11edc6d6cedaf08af0cb747a6db14877a43094","source_role":"adjacent_context"},{"id":"s57","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/47jdzp/delta_sleep_inducing_peptide_dsip_for_treating/","title":"Delta Sleep Inducing Peptide (DSIP) for treating central sleep apnea?","quote":"My sleep tracker showed the longest chunks of uninterrupted sleep it's ever shown and I never woke up during the night. Unfortunately, it brought along a friend, insomnia. I usually fall asleep quickly, but after dosing DSIP it took me well over two hours despite being exhausted.","summary":"User reports initial dramatic improvement in uninterrupted deep sleep per tracker but followed by onset insomnia and longer time to fall asleep on subsequent nights.","author":"","publisher":"","date":"","claim_ids":["c62"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:40.209Z","link_status":"ok","quote_status":"unverified","prev":"539c17412a265e8f51db152bde11edc6d6cedaf08af0cb747a6db14877a43094","hash":"3df615071e807cdfd5fbcc7efd63e6ef838f64aa4b42677d68b28d61d02c0002","source_role":"anecdotal_report"},{"id":"s58","type":"reddit","url":"https://www.reddit.com/r/insomnia/comments/1gu3ele/has_anyone_tried_dsipdelta_sleepinducing_peptide/","title":"Has anyone tried DSIP(Delta Sleep-Inducing Peptide)?","quote":"Took a few days for it to really show its effects on me but I get sleepy with in 15-20 mins of taking my dose and I get the best sleep. If I do wake up I go right back to sleep and I have never felt more rested in the morning.","summary":"Positive user experience: quicker sleep onset after a few days, better sleep continuity, feeling more rested.","author":"","publisher":"","date":"","claim_ids":["c63"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:40.209Z","link_status":"ok","quote_status":"unverified","prev":"3df615071e807cdfd5fbcc7efd63e6ef838f64aa4b42677d68b28d61d02c0002","hash":"907521e557240f3829aac1457894f1e7ecbc6ec23c625732324cb5aafda4f5eb","source_role":"anecdotal_report"},{"id":"s59","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/18u5ocg/dsip_delta_sleep_inducing_peptide/","title":"DSIP (delta sleep inducing peptide)","quote":"I used it for 2 months. I didn't notice much. My results may not reflect those seeking this peptide out as my sleep was already dialed in.","summary":"Neutral to negative: no noticeable effects after 2 months of use for a user with already good sleep.","author":"","publisher":"","date":"","claim_ids":["c64"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:40.209Z","link_status":"ok","quote_status":"unverified","prev":"907521e557240f3829aac1457894f1e7ecbc6ec23c625732324cb5aafda4f5eb","hash":"f84681d3906934067c603c8e6e526f0526596f4c4cb3592938f04bf88c1c4130","source_role":"anecdotal_report"},{"id":"s60","type":"x","url":"https://x.com/whey777/status/2069942524815319485","title":"X post by @whey777","quote":"Lastly, when cycling off of GH secretagogues, I decided to try DSIP (delta sleep inducing peptide). Tons of mixed reviews on this one. Personally, it helped me fall and stay asleep, and I did get better deep sleep. But it also made me sleep a bit longer.","summary":"Mixed positive: helped fall asleep, stay asleep, better deep sleep but increased total sleep time.","author":"","publisher":"","date":"","claim_ids":["c65"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:40.209Z","link_status":"ok","quote_status":"verified","prev":"f84681d3906934067c603c8e6e526f0526596f4c4cb3592938f04bf88c1c4130","hash":"312ff5f601ef3bed2ba08d5f169e6a12445f8318b80c0263364bcfc73b7f0484","source_role":"anecdotal_report"},{"id":"s61","type":"x","url":"https://x.com/troywhiteyyc/status/2068891740736503946","title":"X post by @troywhiteyyc","quote":"I started testing out DSIP for sleep management. First night 1mg- no real major difference - 4 hours Second night 1mg - same amount of sleep Third night 1.5mg - 9 hours No idea if the 9 hours was because of higher dose of DSIP, or that I was just exhausted enough from the prior few nights!","summary":"Dose-dependent trial: lower doses no change, higher dose led to much longer sleep (9 hours) after prior poor nights.","author":"","publisher":"","date":"","claim_ids":["c66"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:40.209Z","link_status":"ok","quote_status":"unverified","prev":"312ff5f601ef3bed2ba08d5f169e6a12445f8318b80c0263364bcfc73b7f0484","hash":"cf11e42f924747eb663cc627f6962628d7ae0724f216b3593ed1f9d0a9132ce6","source_role":"anecdotal_report"},{"id":"s62","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1rakdga/dsip_recovery_and_dreams/","title":"DSIP Recovery and Dreams","quote":"Very recently started DSIP for recovery and it does just that! I don’t feel so sore the next day and get quality sleep-also crazy off the wall dreams.","summary":"Positive user report on improved recovery, sleep quality, and vivid/wild dreams with DSIP use.","author":"","publisher":"","date":"","claim_ids":["c70"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:28.710Z","link_status":"ok","quote_status":"unverified","prev":"cf11e42f924747eb663cc627f6962628d7ae0724f216b3593ed1f9d0a9132ce6","hash":"51a8a1b598cdf93215ed8686fbb7c16292587f79f7bea814983fa718674c6520","source_role":"anecdotal_report"},{"id":"s63","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1rakdga/dsip_recovery_and_dreams/","title":"DSIP Recovery and Dreams","quote":"I just tried it, I dreamt I was selling Holstein cows to a family in Iraq - over the phone. Had another dream I was stealing pink towels from a hotel in China town while my kids ate dumplings on the elevator. I woke up several times, (not new for me) but went back to deep sleep","summary":"Another user's positive/vivid dream experience and ability to return to deep sleep after waking.","author":"","publisher":"","date":"","claim_ids":["c71"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:28.710Z","link_status":"ok","quote_status":"unverified","prev":"51a8a1b598cdf93215ed8686fbb7c16292587f79f7bea814983fa718674c6520","hash":"8233e8475c424a232b73bf594198c1b608f6da0bf8bf839795218043312d08e7","source_role":"anecdotal_report"},{"id":"s64","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1tnualo/peptide_tier_list_for_sleep_ranked_by_sleep/","title":"Peptide tier list for sleep. Ranked by sleep relevance, recovery support, and overall sleep quality","quote":"Svddendemon: Have you taken it? I took a whole bottle and every night I did I got horrible sleep and woke up multiple times through the night.","summary":"Negative experience: poor sleep, frequent awakenings after full course of DSIP.","author":"","publisher":"","date":"","claim_ids":["c72"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:28.710Z","link_status":"ok","quote_status":"unverified","prev":"8233e8475c424a232b73bf594198c1b608f6da0bf8bf839795218043312d08e7","hash":"9400b68ce3e611e7677bce319c5032daa075dc0d8369b666ed491d8a74a29d42","source_role":"anecdotal_report"},{"id":"s65","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1tnualo/peptide_tier_list_for_sleep_ranked_by_sleep/","title":"Peptide tier list for sleep. Ranked by sleep relevance, recovery support, and overall sleep quality","quote":"Taydontplay4: Love DSIP, but I did not initially. I stayed consistent with it and am on my 3rd vial and the magic is happening. It’s almost like my body had an adaptation period to it.","summary":"Positive long-term outcome after initial adaptation period with consistent DSIP use.","author":"","publisher":"","date":"","claim_ids":["c73"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:28.710Z","link_status":"ok","quote_status":"unverified","prev":"9400b68ce3e611e7677bce319c5032daa075dc0d8369b666ed491d8a74a29d42","hash":"1d48057cf8e6d4cee11677ce0d35068a9a15745c873b499e73c10f171d27cc10","source_role":"anecdotal_report"},{"id":"s66","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1tnualo/peptide_tier_list_for_sleep_ranked_by_sleep/","title":"Peptide tier list for sleep. Ranked by sleep relevance, recovery support, and overall sleep quality","quote":"Emmasmom5: DSIP worked but made me feel hung over the next day","summary":"Mixed: effective for sleep but caused next-day hangover-like feeling.","author":"","publisher":"","date":"","claim_ids":["c74"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:28.710Z","link_status":"ok","quote_status":"unverified","prev":"1d48057cf8e6d4cee11677ce0d35068a9a15745c873b499e73c10f171d27cc10","hash":"3303ee8dc6257a2480f122098f7e9aa4299916f75c3e08e0870ec3e1bd706ab2","source_role":"anecdotal_report"},{"id":"s67","type":"anecdotal","url":"https://www.facebook.com/groups/252962560254589/posts/1179093274308175/","title":"DSIP is a peptide to help deep sleep","quote":"DSIP is a peptide to help deep sleep. I'm only on my second day of use but my deep sleep has doubled and happens more often in the night.","summary":"User reports doubling of deep sleep after 2 days of DSIP use, linking to fibromyalgia recovery.","author":"","publisher":"","date":"","claim_ids":["c75"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:51.944Z","link_status":"ok","quote_status":"unverified","prev":"3303ee8dc6257a2480f122098f7e9aa4299916f75c3e08e0870ec3e1bd706ab2","hash":"60189d6ee3214b2bc1104653b54e6fd656b49ae8a3f5483a70d307e64b58e12b","source_role":"anecdotal_report"},{"id":"s68","type":"x","url":"https://x.com/Lions_1776/status/2068064147854516477","title":"X post by @Lions_1776 on DSIP sleep duration","quote":"Have you tried DSIP, Ed? I’m a light sleeper but when using DSIP, I can sleep as long as I like. It’s a nice compound.","summary":"User reports improved ability to sleep longer as a light sleeper with DSIP.","author":"","publisher":"","date":"","claim_ids":["c76"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:51.944Z","link_status":"ok","quote_status":"verified","prev":"60189d6ee3214b2bc1104653b54e6fd656b49ae8a3f5483a70d307e64b58e12b","hash":"c158bd7e1f7c85d52600496a8f2ef44694f4af003ca934c4610dd9ffd616cc17","source_role":"anecdotal_report"},{"id":"s69","type":"x","url":"https://x.com/FattyNoNatty/status/2067706289006985373","title":"X post by @FattyNoNatty on DSIP experience","quote":"You know, I've heard that- I tried DSIP, and I did notice a difference.. but when you just start getting good sleep it doesn't make sense to just keep adding stuff.","summary":"Mildly positive anecdotal report of noticing a difference in sleep with DSIP.","author":"","publisher":"","date":"","claim_ids":["c77"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:51.944Z","link_status":"ok","quote_status":"unverified","prev":"c158bd7e1f7c85d52600496a8f2ef44694f4af003ca934c4610dd9ffd616cc17","hash":"606922cda08e055d069002f4e609df83e3c793ad1e108f1c0b6ccb0a8c382e6a","source_role":"anecdotal_report"},{"id":"s70","type":"reddit","url":"https://www.reddit.com/r/DSPD/comments/pnpial/had_anyone_tried_dsip_peptide_to_reset_their/","title":"Had anyone tried DSIP peptide to reset their circadian rhythm?","quote":"My sleep cycle is roughly 5am-1pm. I can happily fall asleep later than 5am and wake at 3pm, but this is the best I’ve been able to manage so far.","summary":"User seeking experiences with DSIP for circadian rhythm issues; describes personal sleep pattern but no outcome reported in snippet.","author":"","publisher":"","date":"","claim_ids":["c78"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:51.944Z","link_status":"ok","quote_status":"unverified","prev":"606922cda08e055d069002f4e609df83e3c793ad1e108f1c0b6ccb0a8c382e6a","hash":"b75c4c533e7f75c32a54feca0ca658aeae59d39d4b0b2caf92d7f6a681dcdc3c","source_role":"anecdotal_report"},{"id":"s71","type":"x","url":"https://x.com/Chrissssjohnson/status/2008202115186147361","title":"X post on DSIP fixing sleep schedule","quote":"My sleep schedule has been cooked since I came home from Iraq war 14 years ago \n\n14 years of needing sleeping pills to go to sleep\n\nNow, I get sleepy naturally around 9/10 and wake up well rested around 5-6\n\nCircadian rhythm fixed","summary":"Positive user experience: DSIP restored natural sleep schedule and circadian rhythm after long-term issues.","author":"","publisher":"","date":"","claim_ids":["c79"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:36:15.578Z","link_status":"ok","quote_status":"verified","prev":"b75c4c533e7f75c32a54feca0ca658aeae59d39d4b0b2caf92d7f6a681dcdc3c","hash":"4b687ec463fb81c203bd53ae9e81615f956ab0384e512347864bbc88544af5e5","source_role":"anecdotal_report"},{"id":"s72","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1shazrp/dsip_experience/","title":"Dsip experience","quote":"I tried dsip for the first time last night. I went to bed at midnight but woke up at 5 a.m., so much earlier than expected, and my sleep quality felt worse. Is that normal?","summary":"User reports worse sleep and early waking after first DSIP use; comments include ruined sleep, barely slept, next-day fatigue/paralysis, and lower HRV.","author":"","publisher":"","date":"","claim_ids":["c80"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:36:44.744Z","link_status":"ok","quote_status":"unverified","prev":"4b687ec463fb81c203bd53ae9e81615f956ab0384e512347864bbc88544af5e5","hash":"974eb77d6feb129d0ae9c756c4ab0a25ec9ce09263c6d4ad22ac7b9736da4f37","source_role":"anecdotal_report"},{"id":"s73","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1tca76g/peptides_for_sleep_sleep_maintenance_insomnia/","title":"Peptides for Sleep (Sleep Maintenance Insomnia)","quote":"I’ve tried DSIP and it was horrible for me - I slept probably 4 hours. Only benefit was I wasn’t tired the following day.","summary":"OP reports poor outcome (only 4h sleep); other users report zero wake-ups, best sleeps, return of dreaming, high sleep scores post-protocol.","author":"","publisher":"","date":"","claim_ids":["c81"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:36:44.744Z","link_status":"ok","quote_status":"unverified","prev":"974eb77d6feb129d0ae9c756c4ab0a25ec9ce09263c6d4ad22ac7b9736da4f37","hash":"c2f564cf3e963fd060d62c16d55ad599af7c23b0767807eb344b9962f397a284","source_role":"anecdotal_report"},{"id":"s74","type":"reddit","url":"https://www.reddit.com/r/BodyHackGuide/comments/1uhio7j/i_wish_id_discovered_dsip_for_sleep_earlier/","title":"I wish I'd discovered DSIP for sleep earlier","quote":"I've been struggling to get anything more than 3-5 hours of sleep for the half year due to Post Alcohol Withdrawal Syndrome, but I recently added DSIP into my recovery stack and I feel that my sleep has been even better than it was before I ever drank. I'm getting anywhere from 7-9 hours of sleep per night since getting DSIP - but even better is the return of my dreams. They're vivid and memorable now","summary":"Strong positive: improved from 3-5h to 7-9h sleep, vivid memorable dreams, mental rejuvenation after PAWS insomnia.","author":"","publisher":"","date":"","claim_ids":["c82"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:36:44.744Z","link_status":"ok","quote_status":"unverified","prev":"c2f564cf3e963fd060d62c16d55ad599af7c23b0767807eb344b9962f397a284","hash":"b67b7d2b30434a1ff93bf9928565e7f7850cd71122a174de8873f11c65963ab6","source_role":"anecdotal_report"},{"id":"s75","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1p1fbgq/dsip_delta_sleepinducing_peptide_better_deep/","title":"DSIP 💤 (Delta Sleep-Inducing Peptide) Better Deep Sleep | Cortisol Balance | CNS Recovery","quote":"It’s quieter. More structural. Almost invisible until you notice you’re not waking up three times a night anymore. ... Week 2–3: Sleep gets deeper. Dreams get a little heavier. You wake up clearer — not energized, just not foggy.","summary":"Describes gradual benefits: fewer awakenings, deeper sleep, heavier dreams, clearer mornings; subtle structural improvement rather than sedation.","author":"","publisher":"","date":"","claim_ids":["c83"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:36:44.744Z","link_status":"ok","quote_status":"unverified","prev":"b67b7d2b30434a1ff93bf9928565e7f7850cd71122a174de8873f11c65963ab6","hash":"b7433ff819a5c0cfa5f4e63c53dad6d0cb199cc26bd20b0b22b06ca0c5b0b448","source_role":"anecdotal_report"},{"id":"s76","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1bqdrof/im_trying_dsip_for_the_first_time_tonight_does/","title":"Im trying DSIP for the first time tonight, does anyone have any experience? (From my DR)","quote":"I’ve been taking DSIP for about five days now, and I think it’s actually making my deep sleep worse. At first, I was getting around 45 minutes of deep sleep each night and was hoping to improve that. But by the fifth day, I only got 8 minutes.","summary":"User reports negative impact on deep sleep after several days of DSIP use; other commenters share mixed positive experiences with deeper sleep and feeling more rested.","author":"","publisher":"","date":"","claim_ids":["c84"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:37:37.862Z","link_status":"ok","quote_status":"unverified","prev":"b7433ff819a5c0cfa5f4e63c53dad6d0cb199cc26bd20b0b22b06ca0c5b0b448","hash":"0b8e1fc338ed35499d04c3e219b5bf0b666376b702235a52a233f96a8962347b","source_role":"anecdotal_report"},{"id":"s77","type":"reddit","url":"https://www.reddit.com/r/Peptidesource/comments/1ps5lgw/what_was_your_experience_with_dsips/","title":"What Was Your Experience With DSIPS?","quote":"DSiP literally gave me insomnia the two nights I used it.","summary":"Multiple user reports: negative experiences include insomnia or no effect; positive include deeper sleep, fewer awakenings, and better rest quality, especially when cycled.","author":"","publisher":"","date":"","claim_ids":["c85"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:37:37.862Z","link_status":"ok","quote_status":"unverified","prev":"0b8e1fc338ed35499d04c3e219b5bf0b666376b702235a52a233f96a8962347b","hash":"b5e4594aeab4837db27512fc7c1a9e2699bd4672c9dc626317981cde5499d48a","source_role":"anecdotal_report"},{"id":"s78","type":"reddit","url":"https://www.reddit.com/r/BodyHackGuide/comments/1tylecq/dsip_works_but_requires_patience/","title":"DSIP works, but requires patience","quote":"DSIP completely transformed my sleep but not in the way I expected (stick with it) ... When I first started, I actually had a harder time falling asleep. ... around the three-week mark something shifted. My entire sleep architecture just changed. I started hitting what feels like genuinely deep, restorative sleep ... Now I'm a few months in and I haven't noticed any tolerance buildup ... Dose: 300-500mcg SubQ nightly","summary":"User reports initial difficulty falling asleep but after 3 weeks, dramatically improved deep/restorative sleep, vivid dreams, no tolerance after months; recommends patience and 300-500mcg dose. Mixed comments: some saw benefits after adjustment or timing change (e.g. deeper sleep %), others no effect or quit early.","author":"","publisher":"","date":"","claim_ids":["c86"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:38:02.900Z","link_status":"ok","quote_status":"unverified","prev":"b5e4594aeab4837db27512fc7c1a9e2699bd4672c9dc626317981cde5499d48a","hash":"a0a1b3522f2e0a9ae407314c3bd3da69dc393759b0c508e2da242d40996c2ffc","source_role":"anecdotal_report"},{"id":"s79","type":"x","url":"https://x.com/GiffenHealth/status/2068891740736503946","title":"Peptide #26: DSIP","quote":"Peptide #26: DSIP Deep sleep inducer. The one that actually gives you restorative rest without grogginess. Underrated king for anyone whose recovery sucks.","summary":"User describes DSIP as providing restorative deep sleep without grogginess, great for recovery.","author":"","publisher":"","date":"","claim_ids":["c87"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:38:02.900Z","link_status":"ok","quote_status":"verified","prev":"a0a1b3522f2e0a9ae407314c3bd3da69dc393759b0c508e2da242d40996c2ffc","hash":"046709a34dfd673702ed4f717f60a69156f5666485de85e887e1f705beff6c89","source_role":"anecdotal_report"},{"id":"s80","type":"x","url":"https://x.com/TalkingCry97534/status/2071051909964685532","title":"DSIP Spotlight","quote":"DSIP Spotlight: The Delta Sleep-Inducing Peptide. Achieve deeper REM cycles and superior recovery with enhanced sleep architecture.","summary":"Promotional post highlighting deeper REM and recovery benefits from DSIP.","author":"","publisher":"","date":"","claim_ids":["c88"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:38:02.900Z","link_status":"ok","quote_status":"verified","prev":"046709a34dfd673702ed4f717f60a69156f5666485de85e887e1f705beff6c89","hash":"aebe19fa50fffb61415229f7e86c6668935f123dc29730de03ec1f09a3f1af7f","source_role":"anecdotal_report"},{"id":"s81","type":"reddit","url":"https://www.reddit.com/r/BodyOptimization/comments/1p5mc7j/dsip_selank_how_i_leveled_up_my_sleep/","title":"DSIP + Selank: How I Leveled Up My Sleep","quote":"When I paired the two together, I fell asleep faster because my mind was calmer, my sleep felt heavier and more restorative, I woke up fewer times, and I woke up feeling fresh instead of groggy. My heart rate was smoother throughout the night, deep sleep scores increased consistently, I recovered better from training, and I felt more mentally stable during the day.","summary":"User anecdote on stacking DSIP (200mcg) with Selank (500mcg) before bed for improved deep sleep, fewer interruptions, and better recovery. Anecdotal, not advice.","author":"","publisher":"","date":"","claim_ids":["c93"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:35:46.840Z","link_status":"ok","quote_status":"unverified","prev":"aebe19fa50fffb61415229f7e86c6668935f123dc29730de03ec1f09a3f1af7f","hash":"42628a5ac67ea9be9817d48cbf568bfa8d62bcb88e5fcc5b954619c8ab831ff8","source_role":"anecdotal_report"},{"id":"s82","type":"reddit","url":"https://www.reddit.com/r/BodyOptimization/comments/1p5mc7j/dsip_selank_how_i_leveled_up_my_sleep/","title":"DSIP + Selank: How I Leveled Up My Sleep","quote":"200mcg of DSIP and 500mcg Selank about an hour or an hour and a half so before bed","summary":"Dosing anecdote from OP reply: 200mcg DSIP + 500mcg Selank ~1-1.5h before bed. Anecdotal, not advice.","author":"","publisher":"","date":"","claim_ids":["c94"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:35:46.840Z","link_status":"ok","quote_status":"unverified","prev":"42628a5ac67ea9be9817d48cbf568bfa8d62bcb88e5fcc5b954619c8ab831ff8","hash":"a25b1fbc08c89f6093dd9d0bb52022341c5095fd3cdaa5c251ff720c9e8da04c","source_role":"anecdotal_report"},{"id":"s83","type":"reddit","url":"https://www.reddit.com/r/Biohack_Blueprint/comments/1ufcu8a/spotlight_dsip_is_not_just_a_sleep_peptide_the/","title":"Spotlight: DSIP is not just a sleep peptide. The HPA axis story is the bigger story.","quote":"Typical protocols use 100 to 200 mcg per night, taken 30 to 60 minutes before bed. Most people see effects within 1 to 2 weeks. Full HPA recalibration takes 4 to 8 weeks of consistent use.","summary":"Post discusses DSIP beyond sleep for HPA axis/stress regulation, with dosing context (100-200mcg/night). Anecdotal framing in community, not advice.","author":"","publisher":"","date":"","claim_ids":["c95"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:35:46.840Z","link_status":"ok","quote_status":"unverified","prev":"a25b1fbc08c89f6093dd9d0bb52022341c5095fd3cdaa5c251ff720c9e8da04c","hash":"153114f973977741aee47a8e16d540a639a2050e10ec2e8070112d374e1c1b81","source_role":"anecdotal_report"},{"id":"s84","type":"x","url":"https://x.com/sleepdiplomat/status/1957519423457358246","title":"Delta Sleep Inducing Peptides - The Matt Walker Podcast","quote":"In this episode, Matt delves into the curious and cautionary tale of Delta Sleep-Inducing Peptide (DSIP), once hailed as a potential miracle...","summary":"X post linking podcast on DSIP history as potential sleep aid with cautionary notes on evidence.","author":"","publisher":"","date":"","claim_ids":["c96"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:35:46.840Z","link_status":"ok","quote_status":"unverified","prev":"153114f973977741aee47a8e16d540a639a2050e10ec2e8070112d374e1c1b81","hash":"9a690aedd8ae7d6fb771c755e965732a5f89a18920129ebbcea983763b92da77","source_role":"anecdotal_report"},{"id":"s85","type":"x","url":"https://x.com/TKubowitz9tdk/status/2071444996562227309","title":"","quote":"The peptide DSIP may help those already in trouble. Also helps with alcohol, benzodiazepines, opiates and kratom.","summary":"X post anecdotal claim on DSIP for withdrawal/stress issues. Anecdotal, not advice.","author":"","publisher":"","date":"","claim_ids":["c97"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:35:46.840Z","link_status":"ok","quote_status":"verified","prev":"9a690aedd8ae7d6fb771c755e965732a5f89a18920129ebbcea983763b92da77","hash":"5552b59a84ae6520a667c7c53b6ca113532ee4979b4465c8ca57b558020a31bc","source_role":"anecdotal_report"},{"id":"s86","type":"reddit","url":"https://www.reddit.com/r/Ameano_Peptides/comments/1ocobsd/a_complete_guide_for_dsip/","title":"A Complete Guide for DSIP","quote":"DSIP ( Delta Sleep-Inducing Peptide ) is a naturally-occurring nonapeptide found in the brain and other tissues, offered by Ameano Peptides in a research-grade formulation.","summary":"Promotional guide post on DSIP mechanism for sleep regulation; anecdotal dosing not detailed here but notes research compound only, not for human consumption.","author":"","publisher":"","date":"","claim_ids":["c98"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:36:11.020Z","link_status":"ok","quote_status":"unverified","prev":"5552b59a84ae6520a667c7c53b6ca113532ee4979b4465c8ca57b558020a31bc","hash":"0da395d1567a060afb3857f1dcaf164194b065177806157e9e62d7c79cfa4e0e","source_role":"anecdotal_report"},{"id":"s87","type":"reddit","url":"https://www.reddit.com/r/ADHDers/comments/1shiytb/delta_sleepinducing_peptide_dsip_did_it_affect/","title":"Delta Sleep-Inducing Peptide (DSIP) — did it affect your prescription stimulants?","quote":"I have no experience of or knowledge of DSIP.","summary":"Thread asking about DSIP interaction with ADHD meds; one comment notes no experience.","author":"","publisher":"","date":"","claim_ids":["c99"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:36:11.020Z","link_status":"ok","quote_status":"unverified","prev":"0da395d1567a060afb3857f1dcaf164194b065177806157e9e62d7c79cfa4e0e","hash":"587aebc719804f082c056d9b6c5ad410e57797b99a4017b2ce12389114af21b9","source_role":"anecdotal_report"},{"id":"s88","type":"x","url":"https://x.com/HillaryLinMD/status/2071602085401866272","title":"Are peptides back?","quote":"Emideltide / DSIP: D+ for sleep/withdrawal/pain","summary":"MD post on FDA discussion of DSIP (Emideltide) evidence grade D+ for sleep; notes evidence issues but not zero.","author":"","publisher":"","date":"","claim_ids":["c100"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:36:11.020Z","link_status":"ok","quote_status":"verified","prev":"587aebc719804f082c056d9b6c5ad410e57797b99a4017b2ce12389114af21b9","hash":"79d66facf2af220caa36c59750a7c0c54064990a90e6b83f649b4182f618b510","source_role":"anecdotal_report"},{"id":"s89","type":"x","url":"https://x.com/xiipercent/status/2071641514263130279","title":"DSIP experience with blend","quote":"I def feel from DSIP 10mg ; +a tesa/ipa 10/10mg blend. I feel like my own anesthesiologist- straight to sleep.","summary":"Anecdotal positive: DSIP 10mg with blend leads to immediate sleep (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c101"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:36:11.020Z","link_status":"ok","quote_status":"verified","prev":"79d66facf2af220caa36c59750a7c0c54064990a90e6b83f649b4182f618b510","hash":"5e10dd02770ad71498f79f6bc8ed317fd137484fc31ef3410bdcecfe1db62abc","source_role":"anecdotal_report"},{"id":"s90","type":"x","url":"https://x.com/PeptideBuz/status/2071576099931459677","title":"Peptide FDA discussion","quote":"July 24: Emideltide (DSIP), Semax, Epitalon. Seven peptides total. These aren't being \"approved\" — they're being evaluated for return to Category 1 compounding status.","summary":"Update on potential regulatory changes for DSIP (Emideltide); context for user interest in sourcing and effects.","author":"","publisher":"","date":"","claim_ids":["c102"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:36:42.491Z","link_status":"ok","quote_status":"unverified","prev":"5e10dd02770ad71498f79f6bc8ed317fd137484fc31ef3410bdcecfe1db62abc","hash":"4a002f029967c5e0ef9c9b62efd623eaac9138fab934e8339128bf6e9a3dc3ff","source_role":"anecdotal_report"},{"id":"s91","type":"x","url":"https://x.com/xiipercent/status/2071614893732900958","title":"DSIP stack mention","quote":"DSIP. + tesa/ipa blend. your welcome","summary":"User recommending DSIP stack for sleep (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c103"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:37:21.925Z","link_status":"ok","quote_status":"verified","prev":"4a002f029967c5e0ef9c9b62efd623eaac9138fab934e8339128bf6e9a3dc3ff","hash":"9aec603d07f0559780f3e69d99813cc92546bc0d2f300e1f7f4f4e6597fc36aa","source_role":"anecdotal_report"},{"id":"s92","type":"x","url":"https://x.com/AMRadio84/status/2071613491719319677","title":"DSIP sourcing anecdote","quote":"Same here. Grok ruined my Epithalon & DSIP into Peptides. Had to toss them now I use a well known influencer cheat sheet. All is well.","summary":"Anecdotal mention of discarding DSIP due to sourcing concerns (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c104"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:37:21.925Z","link_status":"ok","quote_status":"unverified","prev":"9aec603d07f0559780f3e69d99813cc92546bc0d2f300e1f7f4f4e6597fc36aa","hash":"54b12eb0f7a7192defb6364197ac55671f7e7bcb40d9010b8fd19ac4c196aba0","source_role":"anecdotal_report"},{"id":"s93","type":"reddit","url":"https://www.reddit.com/r/sleep/comments/1l1zbhz/actual_peptides_meds_that_will_give_you_deep_sleep/","title":"Actual peptides / meds that will give you deep sleep?","quote":"YMMV. I've had the worst insomnia from it, tried different brands and dosages over the years. On par with melatonin.. and other 100+ supplements / meds / peptides that either do nothing or worsen my sleep","summary":"User reports worst insomnia from DSIP, tried multiple brands/doses (anecdotal, not advice). Others note it worsened sleep or affected REM differently.","author":"","publisher":"","date":"","claim_ids":["c105"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:38:00.166Z","link_status":"ok","quote_status":"unverified","prev":"54b12eb0f7a7192defb6364197ac55671f7e7bcb40d9010b8fd19ac4c196aba0","hash":"71f59822bfe3ba6c19f511aa2f541a1c36512554d6980dc7a3a32ccbbc31bac9","source_role":"anecdotal_report"},{"id":"s94","type":"reddit","url":"https://www.reddit.com/r/sleep/comments/1l1zbhz/actual_peptides_meds_that_will_give_you_deep_sleep/","title":"Actual peptides / meds that will give you deep sleep?","quote":"Yeah it made my sleep worse I tried it 3 times.","summary":"Comment: DSIP made sleep worse after 3 attempts (anecdotal).","author":"","publisher":"","date":"","claim_ids":["c106"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:38:00.166Z","link_status":"ok","quote_status":"unverified","prev":"71f59822bfe3ba6c19f511aa2f541a1c36512554d6980dc7a3a32ccbbc31bac9","hash":"beb86c59eb10e9f6c9ab6b20ed1aea09988a1813b1a5be97de1f80a6547ff1a7","source_role":"anecdotal_report"},{"id":"s95","type":"reddit","url":"https://www.reddit.com/r/sleep/comments/1l1zbhz/actual_peptides_meds_that_will_give_you_deep_sleep/","title":"Actual peptides / meds that will give you deep sleep?","quote":"Same here. DSIP shots made my sleep a lot worse","summary":"Another user confirms DSIP worsened sleep (anecdotal).","author":"","publisher":"","date":"","claim_ids":["c107"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:38:00.166Z","link_status":"ok","quote_status":"unverified","prev":"beb86c59eb10e9f6c9ab6b20ed1aea09988a1813b1a5be97de1f80a6547ff1a7","hash":"9ecd0b792b2928d9161ffe961cfc54598b9da516d25ab1a2d5389ccdc80bb5be","source_role":"anecdotal_report"},{"id":"s96","type":"reddit","url":"https://www.reddit.com/r/sleep/comments/1l1zbhz/actual_peptides_meds_that_will_give_you_deep_sleep/","title":"Actual peptides / meds that will give you deep sleep?","quote":"I take it and it does not affect sleep time or deep sleep but no matter how little sleep I get, there is always REM and that was not the case pre-DSIP.","summary":"Positive for REM consistency despite no change in deep sleep duration (anecdotal).","author":"","publisher":"","date":"","claim_ids":["c108"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:38:00.166Z","link_status":"ok","quote_status":"unverified","prev":"9ecd0b792b2928d9161ffe961cfc54598b9da516d25ab1a2d5389ccdc80bb5be","hash":"8746b6b9f7cd4958752899f4823c0258de749a6b29e63d23bbe01aa125eecb98","source_role":"anecdotal_report"},{"id":"s97","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1nnfj2w/dsip_intranasalsubq_complete_opiate_withdrawal/","title":"DSIP Intranasal/Sub-Q Complete Opiate Withdrawal Relief","quote":"Current dosage is about 1mg at a time sub-q or 50mcg per nostril. ... Sub-q DSIP provides sustained complete withdrawal relief. Intranasal provides more rapid and pronounced, but shorter lived withdrawal relief.","summary":"Anecdotal report (not advice) of DSIP at 1mg subq or 50mcg intranasal providing complete opiate withdrawal relief and reversing tolerance/dependence; good outcome noted.","author":"","publisher":"","date":"","claim_ids":["c109"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:38:24.650Z","link_status":"ok","quote_status":"unverified","prev":"8746b6b9f7cd4958752899f4823c0258de749a6b29e63d23bbe01aa125eecb98","hash":"e11afda2b5ab2ff53a76da2094290c87d0632d39659c2700785ba6c3d204bae6","source_role":"anecdotal_report"},{"id":"s98","type":"reddit","url":"https://www.reddit.com/r/Biohacking/comments/1rwy37j/how_long_does_a_reconstituted_dsip_vial_actually/","title":"How long does a reconstituted DSIP vial actually last in the fridge?","quote":"I’m running 250 mcg (6.25 units on a U-100 syringe) Monday through Friday and taking weekends off. ... First night (250 mcg DSIP): slept over 6 hours — super smooth and consolidated the whole way... 250 mcg was clearly the winner my overall rest and recovery","summary":"User shares anecdotal dosing (250 mcg nightly M-F) and positive sleep outcomes with DSIP, notes titration and vial storage experiences; labels as research use only.","author":"","publisher":"","date":"","claim_ids":["c110"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:39:34.774Z","link_status":"ok","quote_status":"unverified","prev":"e11afda2b5ab2ff53a76da2094290c87d0632d39659c2700785ba6c3d204bae6","hash":"fe3788435ff5887a3349ad1ab88dc021dbc9631f008e4263a8efa6669c9820a7","source_role":"anecdotal_report"},{"id":"s99","type":"reddit","url":"https://www.reddit.com/r/APRHealthSolutions/comments/1q56i5l/dsip_comprehensive_guide/","title":"DSIP: Comprehensive Guide","quote":"DSIP is commonly studied for: Deep sleep and slow-wave sleep enhancement. Nighttime recovery and regeneration. Stress and overtraining models.","summary":"Guide on DSIP as research compound for sleep architecture, stress, recovery; anecdotal community mentions implied but focused on research context.","author":"","publisher":"","date":"","claim_ids":["c111"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:39:34.774Z","link_status":"ok","quote_status":"unverified","prev":"fe3788435ff5887a3349ad1ab88dc021dbc9631f008e4263a8efa6669c9820a7","hash":"a3a06e4b89d68b8910006140b6aa7608b2173074cc40716deb40cbb6c9c7a552","source_role":"anecdotal_report"},{"id":"s100","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/h0j7cv/dsip_delta_sleep_inducing_peptide_no_effect/","title":"DSIP ( delta sleep inducing peptide ): no effect whatsoever","quote":"DSIP ( delta sleep inducing peptide ): no effect whatsoever. I've tried 125mcg (day time) and ~300mcg (pre sleep). I felt no effects at all ...","summary":"Anecdotal report of no effects from DSIP at tested doses (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c112"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:39:55.122Z","link_status":"ok","quote_status":"unverified","prev":"a3a06e4b89d68b8910006140b6aa7608b2173074cc40716deb40cbb6c9c7a552","hash":"87515a046eec365cf76437c79cc8d53184457f62dbb45e54b55a063531b034a0","source_role":"anecdotal_report"},{"id":"s101","type":"reddit","url":"https://www.reddit.com/r/sleephackers/comments/1ag716c/any_personal_experience_with_dsip_delta/","title":"any personal experience with DSIP (Delta Sleep-Inducing Peptide)?","quote":"I am sleeping through the night MUCH better after a few doses of DSIP.","summary":"Anecdotal positive outcome for sleep maintenance with DSIP (anecdotal, not advice); user cycles every other night.","author":"","publisher":"","date":"","claim_ids":["c113"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:39:55.122Z","link_status":"ok","quote_status":"unverified","prev":"87515a046eec365cf76437c79cc8d53184457f62dbb45e54b55a063531b034a0","hash":"2ced98ecb586e62689dd885b9c5ef39bc41a407307df0059e2acd7f7cfcbe7d5","source_role":"anecdotal_report"},{"id":"s102","type":"x","url":"https://x.com/gr8tful88/status/2071404994192974208","title":"X post listing peptides including DSIP","quote":"Sleep: DSIP, Epitalon.","summary":"Lists DSIP for sleep in peptide overview.","author":"","publisher":"","date":"","claim_ids":["c114"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:40:18.338Z","link_status":"ok","quote_status":"verified","prev":"2ced98ecb586e62689dd885b9c5ef39bc41a407307df0059e2acd7f7cfcbe7d5","hash":"1d7e25d9cc522f346e1092132e1d97ec4c266d450de86d3c8847911d3827d265","source_role":"anecdotal_report"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7405185/","title":"Effect of delta sleep inducing peptide (DSIP) and arginine vasotocin (AVT) on sleep and motor activity in the rat — Tobler I, Borbely AA. Waking Sleeping. 1980;4(2):139-53. PMID 7405185","quote":"It is concluded that neither DSIP nor AVT qualify as a specific sleep-promoting substance.","_id":"w_jrk3aijc","_ts":"2026-08-04T08:28:26.330Z","id":"w_jrk3aijc","type":"source","accessed_at":"2026-08-04T08:28:26.330Z","claim_ids":[],"prev":"1d7e25d9cc522f346e1092132e1d97ec4c266d450de86d3c8847911d3827d265","hash":"52392cc66ad8dfbf1df9fb01bf90623805e953f8e50a2f23492ff3f6f18ff373","plain":"Rats, and an early failure to replicate. Two candidate sleep substances were run side by side and the authors refused the label for both - from a leading sleep laboratory, only a few years after the original claim was made."},{"url":"https://pubmed.ncbi.nlm.nih.gov/265572/","title":"Characterization of a delta-electroencephalogram (-sleep)-inducing peptide — Schoenenberger GA, Monnier M. Proc Natl Acad Sci USA. 1977;74(3):1282-6. PMID 265572","quote":"Amino acid sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. A total of 58 rabbits including controls were evaluated. Only the delta-sleep-inducing peptide (synthetic) showed significant and specific enhancement/induction of delta and spindle electroencephalogram patterns.","_id":"w_y3chk0t1","_ts":"2026-08-04T08:29:41.006Z","id":"w_y3chk0t1","type":"source","accessed_at":"2026-08-04T08:29:41.006Z","claim_ids":[],"prev":"52392cc66ad8dfbf1df9fb01bf90623805e953f8e50a2f23492ff3f6f18ff373","hash":"5209883b98d39dfa789b1c81a7fe59c12bf158357dbfdabb51dbe5289397af4f","plain":"The founding paper: it named the peptide and gave its nine-amino-acid sequence from rabbit work. Everything downstream rests on this - and the group that proposed the substance is the group that tested it, in 1977, using brainwave traces."},{"url":"https://pubmed.ncbi.nlm.nih.gov/1237876/","title":"Humoral transmission of sleep IX: activity and concentration of the sleep peptide delta in cerebral and systemic blood fractions — Monnier M, Dudler L, Gachter R, Schoenenberger GA. Pflugers Arch. 1975;360(3):225-42. PMID 1237876","quote":"The electric thalamic stimulation of donors, with parameters inducing orthodox delta-sleep, parallely increases the delta peptide concentration (160 nM/g) and its activity (543 muV x sec delta integral) in cerebral blood dialysate.","_id":"w_hroqdqlk","_ts":"2026-08-04T08:29:41.315Z","id":"w_hroqdqlk","type":"source","accessed_at":"2026-08-04T08:29:41.315Z","claim_ids":[],"prev":"5209883b98d39dfa789b1c81a7fe59c12bf158357dbfdabb51dbe5289397af4f","hash":"623cb77cdb27027bd031fdf5e3decce3e79d269f47eba77cbd56608ccea3b347","plain":"Where the idea began. Fluid drawn from rabbits whose brains were being electrically driven into deep sleep carried more of the substance and more of the effect - a correlation, measured on 1975 equipment, in animals not sleeping on their own."},{"url":"https://pubmed.ncbi.nlm.nih.gov/568769/","title":"The delta EEG (sleep)-inducing peptide (DSIP) XI: amino-acid analysis, sequence, synthesis and activity of the nonapeptide — Schoenenberger GA, Maier PF, Tobler HJ, Wilson K, Monnier M. Pflugers Arch. 1978;376(2):119-29. PMID 568769","quote":"The mean increase of EEG delta activity reached 35% in the neocortex and limbic cortex as compared to control animals receiving CSF-like solution or any of the other 8 peptides.","_id":"w_1v4zebwc","_ts":"2026-08-04T08:29:41.776Z","id":"w_1v4zebwc","type":"source","accessed_at":"2026-08-04T08:29:41.776Z","claim_ids":[],"prev":"623cb77cdb27027bd031fdf5e3decce3e79d269f47eba77cbd56608ccea3b347","hash":"8593944afa55656b9d45ad8d916ed5d617031e25c1fe3ada88c1b1e3597d6376","plain":"The synthesis paper from the same laboratory: a chemically built version tested against eight other peptides and a blank solution. The brainwave shift is modest in size, and every comparison is internal to the group that proposed the peptide."},{"url":"https://pubmed.ncbi.nlm.nih.gov/3583493/","title":"Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs — Monti JM, Debellis J, Alterwain P, Pellejero T, Monti D. Int J Clin Pharmacol Res. 1987;7(2):105-10. PMID 3583493","quote":"For NREM sleep time and stage 2 sleep differences between DSIP and a placebo were significant, but the same differences existed already for the baseline values. It can be concluded that sleep improvement under DSIP treatment is of little clinical significance.","_id":"w_pkhu2ho3","_ts":"2026-08-04T08:29:42.081Z","id":"w_pkhu2ho3","type":"source","accessed_at":"2026-08-04T08:29:42.081Z","claim_ids":[],"prev":"8593944afa55656b9d45ad8d916ed5d617031e25c1fe3ada88c1b1e3597d6376","hash":"9c1dec985f9cdfe7fef2f8e868a389e5580d1410c10ffff54c28c9754a013a6a","plain":"A human trial, and the one that cuts against the compound. The apparent advantage turned out to sit in the groups before treatment even started, and the investigators said outright that the improvement carried little clinical meaning."},{"url":"https://pubmed.ncbi.nlm.nih.gov/3792404/","title":"Efficacy of DSIP to normalize sleep in middle-aged and elderly chronic insomniacs — Schneider-Helmert D. Eur Neurol. 1986;25(6):448-53. PMID 3792404","quote":"The population of 18 chronic psychophysiological insomniacs was subdivided into two groups of middle-aged (29-59) and older (60-83) insomniacs. The whole sample of insomniacs showed normal sleep patterns at the end of the investigation.","_id":"w_yaqq0mom","_ts":"2026-08-04T08:29:42.373Z","id":"w_yaqq0mom","type":"source","accessed_at":"2026-08-04T08:29:42.373Z","claim_ids":[],"prev":"9c1dec985f9cdfe7fef2f8e868a389e5580d1410c10ffff54c28c9754a013a6a","hash":"3e9b35590a834653d25ba6cd294c7100316f40ee17496cd26cda906fda584308","plain":"Eighteen people with long-standing insomnia, split into a middle-aged and an older group, all sleeping normally by the end. That sounds strong and is the weakest design for proving why: no placebo arm, and insomnia scores improve on attention alone."},{"url":"https://pubmed.ncbi.nlm.nih.gov/6328354/","title":"Successful treatment of withdrawal symptoms with delta sleep-inducing peptide, a neuropeptide with potential agonistic activity on opiate receptors — Dick P, Grandjean ME, Tissot R. Neuropsychobiology. 1983;10(4):205-8. PMID 6328354","quote":"DSIP (25 nmol/kg) was injected intravenously as sole treatment to 67 patients presenting withdrawal symptoms (28 from ethyl alcohol, 39 from opiates). 27% of the patients were lost or unsuitable for evaluation. From the 49 evaluable patients, DSIP produced a beneficial effect in 48.","_id":"w_ee6vmdc4","_ts":"2026-08-04T08:29:42.929Z","id":"w_ee6vmdc4","type":"source","accessed_at":"2026-08-04T08:29:42.929Z","claim_ids":[],"prev":"3e9b35590a834653d25ba6cd294c7100316f40ee17496cd26cda906fda584308","hash":"1f5ef3e5c49b5d10583d9733b85e6241c50191b9111e40d6595e5078112da07a","plain":"Sixty-seven people in alcohol or opiate withdrawal, given it by vein as the only treatment. No control group, no blinding, a quarter of them dropped out of the count, and withdrawal fades by itself - which is exactly what this design cannot rule out."},{"url":"https://pubmed.ncbi.nlm.nih.gov/6548969/","title":"DSIP in the treatment of withdrawal syndromes from alcohol and opiates — Dick P, Costa C, Fayolle K, Grandjean ME, Khoshbeen A, Tissot R. Eur Neurol. 1984;23(5):364-71. PMID 6548969","quote":"DSIP was administered intravenously to 107 inpatients presenting with symptoms of alcohol (n = 47) or opiate (n = 60) withdrawal. The assessment of effect was based on the clinical evaluation by the physician and the nursing staff.","_id":"w_0vnryw2z","_ts":"2026-08-04T08:29:43.305Z","id":"w_0vnryw2z","type":"source","accessed_at":"2026-08-04T08:29:43.305Z","claim_ids":[],"prev":"1f5ef3e5c49b5d10583d9733b85e6241c50191b9111e40d6595e5078112da07a","hash":"d73d33f7bad4f3b71f5a084773853ee51de17cd1675a65238a701c66a9887f44","plain":"The larger follow-up, and the outcome measure is doctors and nurses forming an impression. With no placebo and no blinding it records that the treatment was given and the staff were satisfied, not that the peptide caused the change."},{"url":"https://pubmed.ncbi.nlm.nih.gov/9617990/","title":"Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trial — Backmund M, Meyer K, Rothenhaeusler HB, Soyka M. J Clin Psychopharmacol. 1998;18(3):257-8. PMID 9617990","quote":"Open clinical trial of DSIP in opioid detoxification; no placebo control and no blinding.","_id":"w_5aputa1e","_ts":"2026-08-04T08:29:43.911Z","id":"w_5aputa1e","type":"source","accessed_at":"2026-08-04T08:29:43.911Z","claim_ids":[],"prev":"d73d33f7bad4f3b71f5a084773853ee51de17cd1675a65238a701c66a9887f44","hash":"72320136167c0d2aff8c140dca1e82cc903909b5adc8ad8f523f5b436f0bae15","plain":"The most recent human study of this compound, and it was open-label - everyone knew what was being given and there was nothing to compare against. Detoxification improves over days regardless, and this design cannot separate the two."},{"url":"https://pubmed.ncbi.nlm.nih.gov/6379493/","title":"Development of an enzyme immunoassay for delta sleep-inducing peptide (DSIP) and its use in the determination of the metabolic clearance rate of DSIP administered to dogs — Kato N, Honda Y, Ebihara S, Naruse H, Takahashi Y. Neuroendocrinology. 1984;39(1):39-44. PMID 6379493","quote":"DSIP was found to have a rapid disappearance with a mean metabolic clearance rate of 30.7 +/- 2.5 ml/kg . min and a mean half-life of 4.0 +/- 0.7 min in the dogs. Additional measurement in a monkey and 3 rats revealed a rapid in vivo clearance of DSIP from plasma with a half-life of 2.9 and 2.0 +/- 0.54 min, respectively.","_id":"w_w4ku9pni","_ts":"2026-08-04T08:29:44.193Z","id":"w_w4ku9pni","type":"source","accessed_at":"2026-08-04T08:29:44.193Z","claim_ids":[],"prev":"72320136167c0d2aff8c140dca1e82cc903909b5adc8ad8f523f5b436f0bae15","hash":"9dcd63922be2550061d96fd27a1fb8699c62b6f51aa66eebdd935f5be350f545","plain":"Dogs, with a monkey and three rats alongside. The point is speed: it is cleared from blood within minutes, which puts a hard ceiling on what any single evening dose could still be doing later that night."},{"url":"https://pubmed.ncbi.nlm.nih.gov/3628078/","title":"Degradation and aggregation of delta sleep-inducing peptide (DSIP) and two analogs in plasma and serum — Graf MV, Saegesser B, Schoenenberger GA. Peptides. 1987;8(4):599-603. PMID 3628078","quote":"It was concluded that the rapid disappearance of injected DSIP in blood was due to degradation, whereas complex formation together with slower degradation resulted in longer persistence of apparently intact analogs.","_id":"w_nxo79twi","_ts":"2026-08-04T08:29:44.505Z","id":"w_nxo79twi","type":"source","accessed_at":"2026-08-04T08:29:44.505Z","claim_ids":[],"prev":"9dcd63922be2550061d96fd27a1fb8699c62b6f51aa66eebdd935f5be350f545","hash":"a3d2d0a91a0c327c4dac5d232f7cba69bc42ed13b5c2a12af6dea641d7c9c6c6","plain":"Explains the vanishing act - the peptide is chopped up in blood rather than merely filtered out, and modified versions last longer, which is why analogues exist. A laboratory measurement about survival, silent on whether any of it works."},{"url":"https://pubmed.ncbi.nlm.nih.gov/8475226/","title":"Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women — Giusti M, Carraro A, Porcella E, Valenti S, Nicora D, Sessarego P, Giordano G. Psychoneuroendocrinology. 1993;18(1):79-84. PMID 8475226","quote":"Serum GH and PRL levels were normal under basal conditions and no effects were noted after the infusion of DSIP. The GH and PRL circadian rhythm was not modified by DSIP administration.","_id":"w_zga2djoc","_ts":"2026-08-04T08:29:44.779Z","id":"w_zga2djoc","type":"source","accessed_at":"2026-08-04T08:29:44.779Z","claim_ids":[],"prev":"a3d2d0a91a0c327c4dac5d232f7cba69bc42ed13b5c2a12af6dea641d7c9c6c6","hash":"517d12460731be19e85f0f3fbd33e203b2e96637dc93e6bc271392c51073ec34","plain":"Healthy women, infused and tracked across a full day. It is a direct human test of the growth-hormone story attached to this peptide, aimed at exactly that claim, and it found nothing. Small, but human and specific."},{"url":"https://pubmed.ncbi.nlm.nih.gov/3550343/","title":"Delta sleep-inducing peptide (DSIP) stimulates LH release in steroid-primed ovariectomized rats — Sahu A, Kalra SP. Life Sci. 1987;40(12):1201-6. PMID 3550343","quote":"While intraventricular administration of DSIP (2 or 10 micrograms) failed to affect LH release in ovariectomized rats, in two separate experiments DSIP promptly stimulated LH release in ovariectomized estrogen, progesterone-primed rats. However, DSIP had no effect on either basal or LHRH-induced in vitro LH release from the hemipituitaries.","_id":"w_lq5x8aor","_ts":"2026-08-04T08:29:45.079Z","id":"w_lq5x8aor","type":"source","accessed_at":"2026-08-04T08:29:45.079Z","claim_ids":[],"prev":"517d12460731be19e85f0f3fbd33e203b2e96637dc93e6bc271392c51073ec34","hash":"a4ee8fca8f1685843ede1566f03278bf030f6a39f199c7da1ecf30506ee46cab","plain":"Rats with ovaries removed, where the hormone effect showed up only in animals first given oestrogen and progesterone, and not at all in isolated pituitary tissue. Whatever is happening is indirect and depends on the hormonal background."},{"url":"https://pubmed.ncbi.nlm.nih.gov/26470489/","title":"The influence of delta sleep-inducing peptide on functional state of rats hepatocytes in foot-shock stress — Belykh AE, Bobyntsev II, Kryukov AA, Dudka VT. Ross Fiziol Zh Im I M Sechenova. 2015;101(6):700-7. PMID 26470489","quote":"It was observed that 120 mcg/kg peptide normalized the elevation of malondialdehyde (MDA) level in the liver homogenate caused by acute foot-shock stress. Peptide in all doses provided the normalization of protein synthetic hepatocyte function.","_id":"w_cqubqjkn","_ts":"2026-08-04T08:29:45.402Z","id":"w_cqubqjkn","type":"source","accessed_at":"2026-08-04T08:29:45.402Z","claim_ids":[],"prev":"a4ee8fca8f1685843ede1566f03278bf030f6a39f199c7da1ecf30506ee46cab","hash":"2f3a12c6a27abafc5124255a46abed2fabf39f7ac56b712f77cf61f42d1f5aac","plain":"Rats given electric foot shocks, with liver chemistry as the readout. It supports a general stress-buffering story at a stated dose, not a sleep story, and the stress is an acute laboratory shock rather than anything resembling ordinary strain."},{"url":"https://pubmed.ncbi.nlm.nih.gov/15911358/","title":"Antiepileptic activity of delta sleep-inducing peptide and its analogue in metaphit-provoked seizures in rats — Stanojlovic OP, Zivanovic DP, Mirkovic SD, Mikhaleva II. Seizure. 2005;14(4):240-7. PMID 15911358","quote":"DSIP and DSIP-12 significantly increased in delta and theta frequency bands and decreased the incidence, mean seizure grade and duration of metaphit convulsions.","_id":"w_1pggv0x0","_ts":"2026-08-04T08:29:45.715Z","id":"w_1pggv0x0","type":"source","accessed_at":"2026-08-04T08:29:45.715Z","claim_ids":[],"prev":"2f3a12c6a27abafc5124255a46abed2fabf39f7ac56b712f77cf61f42d1f5aac","hash":"391fb10a7b25efff8c1a8e9b7f832c3fdb19202e0b62434db887ae25c1bec073","plain":"Seizures chemically provoked in rats, fewer and milder with the peptide and with a modified version of it. An anticonvulsant signal in one artificial model, never carried forward into human testing."},{"url":"https://pubmed.ncbi.nlm.nih.gov/6549349/","title":"Antagonism of the effect of delta sleep-inducing peptide by naloxone in the rat — Young AM, Key BJ. Neuropharmacology. 1984;23(11):1347-50. PMID 6549349","quote":"This sleep promoting effect was blocked by pre-treatment with the opiate antagonist naloxone at a dose level (0.1 mg/Kg s.c.) considered selective for mu-receptors.","_id":"w_xwm13uhv","_ts":"2026-08-04T08:29:46.056Z","id":"w_xwm13uhv","type":"source","accessed_at":"2026-08-04T08:29:46.056Z","claim_ids":[],"prev":"391fb10a7b25efff8c1a8e9b7f832c3fdb19202e0b62434db887ae25c1bec073","hash":"53904f6087c5cfc0278fb3fc98687fdd93eb7f1d2145c3565dc5c40d66ff006f","plain":"A small rat pharmacology result with a large implication: blocking opioid receptors abolished the sleep effect entirely. If the sedation runs through that system, this is not the clean unrelated sleep switch the name implies."},{"url":"https://pubmed.ncbi.nlm.nih.gov/6548967/","title":"Some pharmacological effects of delta-sleep-inducing peptide (DSIP) — Scherschlicht R, Aeppli L, Polc P, Haefely W. Eur Neurol. 1984;23(5):346-52. PMID 6548967","quote":"In cats, 25 micrograms x kg-1 i.v. and 100 micrograms x kg-1 s.c. preferentially augmented REM sleep. In most experimental situations, indications for bell-shaped dose-response curves of DSIP were found.","_id":"w_lklbxmce","_ts":"2026-08-04T08:29:46.381Z","id":"w_lklbxmce","type":"source","accessed_at":"2026-08-04T08:29:46.381Z","claim_ids":[],"prev":"53904f6087c5cfc0278fb3fc98687fdd93eb7f1d2145c3565dc5c40d66ff006f","hash":"d1fa7953fc1b69896f58119a39b94ee00f926abdd060763a5f02c2c29b4ccdc6","plain":"Cats, dosed two ways. What matters is the shape of the response rather than its size - a hump, not a slope. Past the peak a larger dose does less, so raising the amount when nothing happens works against you."},{"url":"https://pubmed.ncbi.nlm.nih.gov/6548966/","title":"Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP) — Schoenenberger GA. Eur Neurol. 1984;23(5):321-45. PMID 6548966","quote":"I.c.v., i.v. and s.c. administration yielded, in contrast to pharmaka, a parabolic dose-response curve with different effective optima. The half-life time for proteolytic split-off of tryptophan by brain slices and homogenates is 15 min.","_id":"w_6nqi6ir3","_ts":"2026-08-04T08:29:46.726Z","id":"w_6nqi6ir3","type":"source","accessed_at":"2026-08-04T08:29:46.726Z","claim_ids":[],"prev":"d1fa7953fc1b69896f58119a39b94ee00f926abdd060763a5f02c2c29b4ccdc6","hash":"bb4fa7fa8fc4a215e1aa24cc99cab659fef21fac03b268a3b256199dc1259f8e","plain":"The discovering laboratory's own review, conceding two awkward parts: no straight line from dose to effect, and brain tissue starts clipping the peptide apart within minutes. Written by the person who proposed it, so weigh the favourable passages accordingly."},{"url":"https://clinicaltrials.gov/api/v2/studies?query.term=%22delta+sleep-inducing+peptide%22&countTotal=true","title":"ClinicalTrials.gov API v2 query for \"delta sleep-inducing peptide\" and for emideltide, run 4 August 2026","quote":"totalCount: 0. Separate queries for the term \"emideltide\" and for DSIP as a registered intervention also returned totalCount 0 — no registered clinical trial of the compound exists in the registry.","_id":"w_z711kz2m","_ts":"2026-08-04T08:29:47.037Z","id":"w_z711kz2m","type":"source","accessed_at":"2026-08-04T08:29:47.037Z","claim_ids":[],"prev":"bb4fa7fa8fc4a215e1aa24cc99cab659fef21fac03b268a3b256199dc1259f8e","hash":"23f895d96bd970d46d8c07cb576030a54821ab3f755027e4cfef1029abee5e18","plain":"Three separate searches of the federal trial registry - the peptide's name, its drug name, and it as a listed intervention - all came back empty. There is no registered human trial anywhere for anyone to be waiting on."},{"url":"https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks","title":"FDA — Certain Bulk Drug Substances for Use in Compounding That May Present Significant Safety Risks; table: Bulk drug substances nominated but withdrawn","quote":"Emideltide (DSIP): Compounded drugs containing emideltide may pose risk for immunogenicity for certain routes of administration and may have complexities with regard to peptide-related impurities and API characterization. FDA has not identified safety-related information regarding emideltide for the proposed route of administration. Therefore, the agency lacks sufficient information to know whether the drug would cause harm if administered to humans.","_id":"w_ww3yt0x9","_ts":"2026-08-04T08:29:47.404Z","id":"w_ww3yt0x9","type":"source","accessed_at":"2026-08-04T08:29:47.404Z","claim_ids":[],"prev":"23f895d96bd970d46d8c07cb576030a54821ab3f755027e4cfef1029abee5e18","hash":"6960d5a315ee31d0a49e1a83563d435057bbed2622a7a31da98cb35019f3356d","plain":"The agency's own table of nominations that were pulled. Withdrawn is not refused: it leaves the compound neither approved nor formally banned, and the stated worries are impurities, characterisation and immune reaction rather than a known injury."},{"url":"https://pubmed.ncbi.nlm.nih.gov/30692228/","title":"The Pain of Sleep Loss: A Brain Characterization in Humans — Krause AJ, Prather AA, Wager TD, Lindquist MA, Walker MP. J Neurosci. 2019;39(12):2291-2300. PMID 30692228","quote":"Sleep deprivation expands the temperature range for classifying a stimulus as painful, specifically through a lowering of pain thresholds. Even modest nightly changes in sleep quality (increases and decreases) within an individual determine consequential day-to-day changes in experienced pain.","_id":"w_9shvk46m","_ts":"2026-08-04T08:29:48.420Z","id":"w_9shvk46m","type":"source","accessed_at":"2026-08-04T08:29:48.420Z","claim_ids":[],"prev":"6960d5a315ee31d0a49e1a83563d435057bbed2622a7a31da98cb35019f3356d","hash":"5b1e90d670fa39297f355c4c9cd530ad9db5abfd465ea00788c7f5a5dd691bb8","plain":"Nothing to do with the peptide. It is on the page because it pins down what people are actually chasing - lose sleep and the temperature at which heat starts registering as pain drops, and it tracks night to night within the same person."},{"url":"https://pubmed.ncbi.nlm.nih.gov/26194577/","title":"Experimental Sleep Restriction Facilitates Pain and Electrically Induced Cortical Responses — Matre D, Hu L, Viken LA, et al. Sleep. 2015;38(10):1607-17. PMID 26194577","quote":"Pain testing was performed after 2 nights of 50% sleep restriction and after 2 nights with habitual sleep. Pressure pain threshold of the trapezius muscle region also decreased after SR (P = 0.017).","_id":"w_2zo637na","_ts":"2026-08-04T08:29:48.967Z","id":"w_2zo637na","type":"source","accessed_at":"2026-08-04T08:29:48.967Z","claim_ids":[],"prev":"5b1e90d670fa39297f355c4c9cd530ad9db5abfd465ea00788c7f5a5dd691bb8","hash":"9d284d51955418a7378631bf35f91cfd1282e8a253e06abbaeb1d32442c5b89f","plain":"Volunteers cut to half a night's sleep, twice over. Pressure began hurting sooner afterwards. Because sleep was the thing manipulated, the direction is causal - but two lab nights are not a chronic sleep problem."},{"url":"https://pubmed.ncbi.nlm.nih.gov/24290442/","title":"The association of sleep and pain: an update and a path forward — Finan PH, Goodin BR, Smith MT. J Pain. 2013;14(12):1539-52. PMID 24290442","quote":"A key trend emerging from population-based longitudinal studies is that sleep impairments reliably predict new incidents and exacerbations of chronic pain. Sleep impairments are a stronger, more reliable predictor of pain than pain is of sleep impairments.","_id":"w_47nktqzd","_ts":"2026-08-04T08:29:49.339Z","id":"w_47nktqzd","type":"source","accessed_at":"2026-08-04T08:29:49.339Z","claim_ids":[],"prev":"9d284d51955418a7378631bf35f91cfd1282e8a253e06abbaeb1d32442c5b89f","hash":"a12c561a8e227b930d6310ff4cb6066103b5864589806303b35f819f57316aa1","plain":"A review of long-term population studies that settles which way the arrow points: poor sleep predicts new and worsening pain more dependably than pain predicts poor sleep. Background for the page, with no bearing on any peptide."},{"url":"https://pubmed.ncbi.nlm.nih.gov/30107617/","title":"Sleep fragmentation delays wound healing in a mouse model of type 2 diabetes — McLain JM, Alami WH, Glovak ZT, et al. Sleep. 2018;41(11):zsy156. PMID 30107617","quote":"Days to achieve 50 per cent wound healing were 13.3 +/- 0.4 with sleep fragmentation compared with 10.3 +/- 0.7 without sleep fragmentation.","_id":"w_ikb821wn","_ts":"2026-08-04T08:29:49.889Z","id":"w_ikb821wn","type":"source","accessed_at":"2026-08-04T08:29:49.889Z","claim_ids":[],"prev":"a12c561a8e227b930d6310ff4cb6066103b5864589806303b35f819f57316aa1","hash":"abaffbe2c125d676a3cce67ab31280578af0d235a217b3dbe7ae803169f4f646","plain":"Diabetic mice whose sleep was deliberately broken up took about three days longer to get a wound halfway closed. The animal version of the sleep-and-repair argument - a fair reason to care about sleep, and no evidence about a compound."},{"url":"https://pubmed.ncbi.nlm.nih.gov/26054060/","title":"Cognitive Behavioral Therapy for Chronic Insomnia: A Systematic Review and Meta-analysis — Trauer JM, Qian MY, Doyle JS, Rajaratnam SM, Cunnington D. Ann Intern Med. 2015;163(3):191-204. PMID 26054060","quote":"At the posttreatment time point, SOL improved by 19.03 (95% CI, 14.12 to 23.93) minutes, WASO improved by 26.00 (CI, 15.48 to 36.52) minutes, and SE% improved by 9.91% (CI, 8.09% to 11.73%). No adverse outcomes were reported.","_id":"w_363tewrt","_ts":"2026-08-04T08:29:50.259Z","id":"w_363tewrt","type":"source","accessed_at":"2026-08-04T08:29:50.259Z","claim_ids":[],"prev":"abaffbe2c125d676a3cce67ab31280578af0d235a217b3dbe7ae803169f4f646","hash":"7b610eaf538f1755c4589d10acda54dffd2d6a97b237d32ad2c182c46edabd3c","plain":"The comparator with the strongest evidence behind it, and it is not a drug at all. Pooled across trials of a talk-based treatment for long-term insomnia, every standard sleep measure improved with no harms reported. That is the bar to clear."},{"url":"https://pubmed.ncbi.nlm.nih.gov/35843245/","title":"Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis — De Crescenzo F, et al. Lancet. 2022;400(10347):170-184. PMID 35843245","quote":"We included 170 trials (36 interventions and 47,950 participants). In terms of acute treatment, benzodiazepines, doxylamine, eszopiclone, lemborexant, seltorexant, zolpidem, and zopiclone were more efficacious than placebo (SMD range 0.36-0.83). Melatonin, ramelteon, and non-licensed drugs did not show overall material benefits.","_id":"w_ry66bqki","_ts":"2026-08-04T08:29:50.584Z","id":"w_ry66bqki","type":"source","accessed_at":"2026-08-04T08:29:50.584Z","claim_ids":[],"prev":"7b610eaf538f1755c4589d10acda54dffd2d6a97b237d32ad2c182c46edabd3c","hash":"0181f01578ae4c9bf21bfe38ff3aec60c9abbf0f5b6cc8b76eac5b4ccfe680f3","plain":"One hundred and seventy trials and close to fifty thousand people, ranking sleep drugs against placebo and each other. It sits here as the measuring stick: this peptide has never been entered into a comparison of that kind and could not be placed on it."},{"url":"https://pubmed.ncbi.nlm.nih.gov/16539679/","title":"Delta sleep-inducing peptide (DSIP): a still unresolved riddle — Kovalzon VM, Strekalova TV. J Neurochem. 2006;97(2):303-9. PMID 16539679","quote":"The link between DSIP and sleep has never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor. Thus the hypothesis regarding DSIP as a sleep factor is extremely poorly documented and still weak.","_id":"w_l0pqsfj3","_ts":"2026-08-04T08:29:50.972Z","id":"w_l0pqsfj3","type":"source","accessed_at":"2026-08-04T08:29:50.972Z","claim_ids":[],"prev":"0181f01578ae4c9bf21bfe38ff3aec60c9abbf0f5b6cc8b76eac5b4ccfe680f3","hash":"acca4ba3bfdbf18da3b8edb5502ab8cd65915cf86223eeb943676579fa2aab15","plain":"The verdict from inside the sleep field, three decades on. No gene, no protein and no receptor were ever pinned down, and the authors call the sleep hypothesis poorly documented and weak - a judgement from people who worked on it."},{"url":"https://pubmed.ncbi.nlm.nih.gov/41490200/","title":"Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions — Rahman OF, Lee SJ, Seeds WA. J Am Acad Orthop Surg Glob Res Rev. 2026;10(1):e25.00236. PMID 41490200","quote":"Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pinealon target circadian and mitochondrial regulators. Although preclinical studies are promising, there is a current lack of clinical trials.","_id":"w_d2edzzyj","_ts":"2026-08-04T08:29:51.440Z","id":"w_d2edzzyj","type":"source","accessed_at":"2026-08-04T08:29:51.440Z","claim_ids":[],"prev":"acca4ba3bfdbf18da3b8edb5502ab8cd65915cf86223eeb943676579fa2aab15","hash":"aaa6691e29fc1a54100ccf63cbdba078dc34d3fc01940eb44ad3355cc39d35d5","plain":"A 2026 clinical journal listing it among recovery peptides, which is largely how it reaches people now. The review flags its own gap in the same breath: animal work only, no clinical trials. Opinion and summary, not new evidence."},{"url":"https://pubmed.ncbi.nlm.nih.gov/3368469/","title":"Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat — Iyer KS, Marks GA, Kastin AJ, McCann SM. Proc Natl Acad Sci USA. 1988;85(10):3653-6. PMID 3368469","quote":"Male rats were deprived of sleep for 4 hr by placing them on a slowly rotating wheel. These increases were blocked by microinjection into the third cerebral ventricle of highly specific antiserum to DSIP.","_id":"w_7lo702h8","_ts":"2026-08-04T08:29:52.642Z","id":"w_7lo702h8","type":"source","accessed_at":"2026-08-04T08:29:52.642Z","claim_ids":[],"prev":"aaa6691e29fc1a54100ccf63cbdba078dc34d3fc01940eb44ad3355cc39d35d5","hash":"3133bbd612aca74c45c02f5254eef74a2a712c38c7599d96a305828bdd1bb52c","plain":"Rats kept awake on a slowly turning wheel. Blocking the animals' own peptide with an antibody injected into the brain removed the rebound, the best evidence that the body's own supply matters - a different question from whether injecting more helps."},{"url":"https://pubmed.ncbi.nlm.nih.gov/15636354/","title":"Effects of sleep deprivation, nicotine, and selenium on wound healing in rats — Gumustekin K, Seven B, Karabulut N, et al. Int J Neurosci. 2004;114(11):1433-42. PMID 15636354","quote":"The number of fibroblasts and capillary vessels were higher in control and Se groups than in sleep deprivation and nicotine groups. The results suggest that sleep deprivation and nicotine may delay wound healing.","_id":"w_7fiszq9g","_ts":"2026-08-04T08:29:53.108Z","id":"w_7fiszq9g","type":"source","accessed_at":"2026-08-04T08:29:53.108Z","claim_ids":[],"prev":"3133bbd612aca74c45c02f5254eef74a2a712c38c7599d96a305828bdd1bb52c","hash":"afb7f9538253b4e903e6689ed6effbbfa2663b97321920fb35013447fc337f89","plain":"Sleep-deprived rats healed with fewer repair cells and fewer new blood vessels than rats allowed to sleep. Supporting background on why sleep matters to recovery; nicotine was tested in the same study, and no peptide was involved."}],"reviews":[],"extra":{"proven_work":{"work_id":"PW-0020","claim":"This object is a documentation work product on DSIP (delta sleep-inducing peptide), whose stated conclusion is that the peptide is named for the one effect its evidence supports least. What was asked: make it inspectable as an object. What was done in this session: five sibling work objects were bound into the body and the machine view. What was considered and rejected: rewriting the prose. What is guaranteed: 102 claims are addressable and tiered, 132 sources are registered, every write carries a receipt. What is open: a small number of unbound claims, and prose formation payloads not bound to this object.","claim_reconstructed":true,"claim_authorship":"This claim was written after the work it describes, by the session that atomised the claims and bound the sibling relationships. Under spec 1.1.0 rule f it is declared reconstructed.","spec":"https://miscsubjects.com/a/proven-work (PROVEN_WORK_SPEC 1.1.0)","article_scope":"article:dsip","requirements":[{"id":"claims_atomised","status":"PASS","what":"102 claims are stored as addressable units on this object, each carrying an id, a section, and an evidence tier. Tier distribution: anecdotal 72, human 9, mechanistic 2, preclinical 4, speculative 14, system 1. They generate the DIV/voxel structure, so every sentence of argument has its own hash and challenge surface. Tiers outside the five-tier evidence law (human/preclinical/anecdotal/mechanistic/speculative): system — inherited from earlier writes, declared not hidden.","evidence":["inv_3l3aefxzcz"]},{"id":"claims_bound_or_gap_named","status":"GAP","what":"100 of 102 claims carry source ids and 0 more carry an explicit source_status sentence naming why no source is attachable. 2 claims carry neither and are unsupported until bound. 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PARTIAL means at least one requirement is a named gap, printed on the object."}},"has_traversal":false,"register":"essay","status":"published","revisions":67,"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T08:33:21.447Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"DSIP: Natural Deep Sleep","register":"source_ledger","body":"## Evidence-Graded Overview\n\nDSIP (Delta Sleep-Inducing Peptide) is a nonapeptide first isolated from rabbit cerebral venous blood. Preclinical studies in multiple species have examined its association with slow-wave sleep.\n\n## Preclinical Data (Animal and Cell Studies)\n\nRat studies link endogenous DSIP to slow-wave sleep (SWS) induction and sleep-related growth hormone release. Sleep deprivation in rats increased SWS and plasma GH; these increases were blocked by DSIP antiserum (preclinical tier).\n\nDSIP administration has promoted sleep parameters in rabbits, rats, cats, and mice (preclinical tier).\n\n## Human Trial Data\n\nSmall double-blind and open studies from the 1980s reported objective sleep improvements in chronic insomniacs. One 1992 study (n=16) found higher sleep efficiency and shorter latency versus placebo, with no subjective quality change (human tier).\n\nA 1981 study (n=6) noted longer sleep duration, fewer interruptions, and slightly more REM without daytime sedation (human tier).\n\nResults across limited human studies have been variable; no large-scale modern randomized controlled trials exist (human tier).\n\n## Mechanistic and Speculative Notes\n\nDSIP is described as promoting sleep pressure rather than acting as a sedative (mechanistic tier). No human data support suppression of natural sleep architecture or comparison to pharmaceutical hypnotics.\n\n## Anecdotal/User Reports\n\nSparse user reports mention subjective increases in tracked deep sleep stages without next-day effects (anecdotal tier).\n\n## Limitations\n\nAll human data derive from small, dated trials with mixed outcomes. No large human datasets available.","claims":[{"id":"c1","text":"Rat studies show DSIP antiserum blocks sleep-deprivation-induced increases in SWS and GH release.","section":"Preclinical Data","tier":"preclinical","source_ids":["s1"],"source_status":"sourced","why_material":"Separates rat data from human evidence.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"1992 double-blind study (n=16 chronic insomniacs) reported higher objective sleep efficiency and shorter latency with DSIP vs placebo, but no subjective change.","section":"Human Trial Data","tier":"human","source_ids":["s2"],"source_status":"sourced","why_material":"Primary human trial result, small sample noted.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"1981 study (n=6 insomniacs) found longer sleep duration, fewer interruptions, and more REM with DSIP, without daytime sedation.","section":"Human Trial Data","tier":"human","source_ids":["s3"],"source_status":"sourced","why_material":"Additional small human trial separating from preclinical.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c4","text":"DSIP promotes sleep in rabbits, rats, cats, and mice.","section":"Preclinical Data","tier":"preclinical","source_ids":["s4"],"source_status":"sourced","why_material":"Animal species-specific data.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c5","text":"Limited user reports note subjective deep sleep increases on tracking without hangover effects.","section":"Anecdotal/User Reports","tier":"anecdotal","source_ids":["s5"],"source_status":"sourced","why_material":"Distinguishes user reports from trials.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"pubmed","url":"https://www.pnas.org/doi/10.1073/pnas.85.10.3653","title":"Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat","quote":"These increases were blocked by microinjection into the third cerebral ventricle of highly specific antiserum to DSIP.","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/1299794/","title":"Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study","quote":"The results for objective sleep quality indicated higher sleep efficiency and shorter sleep latency with DSIP as compared to placebo.","link_status":"ok","quote_status":"verified"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/7028502/","title":"The influence of synthetic DSIP on disturbed human sleep","quote":"longer sleep duration and a higher quality of sleep with fewer interruptions; slightly more REM-sleep, but no day-time sedation","link_status":"ok","quote_status":"verified"},{"id":"s4","type":"review","url":"https://journals.lww.com/ejanaesthesiology/fulltext/2001/07000/delta_sleep_inducing_peptide.1.aspx","title":"Delta sleep-inducing peptide","quote":"DSIP promotes sleep and this has been demonstrated in rabbits, mice, rats, cats and human beings","link_status":"ok","quote_status":"verified"},{"id":"s5","type":"instagram","url":"https://www.instagram.com/reel/DURfvtYj6Qz/","title":"DSIP Peptide user discussion","quote":"my deep sleep is soooo high. It doesn't make you tired or ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"44e6b89c77f3c5c87735be992cb81463a2e4445f4f9230f3c3d07f49ec815740"},{"seq":1,"id":"k2","ts":"2026-06-29T09:51:06.624Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16539679/","title":"Delta sleep-inducing peptide (DSIP): a still unresolved riddle","quote":"Delta sleep-inducing peptide (DSIP) was isolated from rabbit cerebral venous blood by Schoenenberger-Monnier group from Basel in 1977 and initially regarded as a candidate sleep-promoting factor.","link_status":"ok","quote_status":"verified"},{"id":"s7","type":"review","url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1439536/full","title":"Pichia pastoris secreted peptides crossing the blood-brain barrier","quote":"Delta sleep-inducing peptide (DSIP) is composed of 9 amino acids and has been implicated in the regulation of sleep, modulation of stress (Morgan, 2023), and exhibits a wide range of physiological and pharmacological effects.","link_status":"ok","quote_status":"unverified"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/34500605/","title":"Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke","quote":"Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.","link_status":"ok","quote_status":"verified"},{"id":"s9","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1pcdd5q/dsip_review_the_sleep_peptide_that_gave_me/","title":"DSIP Review: The Sleep Peptide That Gave Me Inception Level Lucid Dreams","quote":"it’s like Inception in a bottle. 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DSIP shots made my sleep a lot worse","link_status":"ok","quote_status":"unverified"},{"id":"s96","type":"reddit","url":"https://www.reddit.com/r/sleep/comments/1l1zbhz/actual_peptides_meds_that_will_give_you_deep_sleep/","title":"Actual peptides / meds that will give you deep sleep?","quote":"I take it and it does not affect sleep time or deep sleep but no matter how little sleep I get, there is always REM and that was not the case pre-DSIP.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"90f17e31c4fbf112cb8e2a9935cbd872bdff1de569ed74cf1eacb1f9378df9a5","hash":"ff0f176634d9ea890c2aa4ff42bda408f9d0bc07c9d2521e8155b0a89c5ea70b"},{"seq":30,"id":"k31","ts":"2026-06-29T17:38:24.663Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s97","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1nnfj2w/dsip_intranasalsubq_complete_opiate_withdrawal/","title":"DSIP Intranasal/Sub-Q Complete Opiate Withdrawal Relief","quote":"Current dosage is about 1mg at a time sub-q or 50mcg per nostril. ... 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I felt no effects at all ...","link_status":"ok","quote_status":"unverified"},{"id":"s101","type":"reddit","url":"https://www.reddit.com/r/sleephackers/comments/1ag716c/any_personal_experience_with_dsip_delta/","title":"any personal experience with DSIP (Delta Sleep-Inducing Peptide)?","quote":"I am sleeping through the night MUCH better after a few doses of DSIP.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"fa5023ad7c95de59256ae9fc9f8d4a0705b5d6ebe9ead449a3ba828241f2ecc8","hash":"5a96a62ecdb83e59a7e187a9ae350688298b00ab5357c0727a0e8e1659966361"},{"seq":33,"id":"k34","ts":"2026-06-29T17:40:18.712Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s102","type":"x","url":"https://x.com/gr8tful88/status/2071404994192974208","title":"X post listing peptides including DSIP","quote":"Sleep: DSIP, Epitalon.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"5a96a62ecdb83e59a7e187a9ae350688298b00ab5357c0727a0e8e1659966361","hash":"995f74d6aff3aa5fa5f51f2f5dc4919e4b6e11665f85fa0edd9dbb50ca95b49c"},{"seq":34,"id":"k35","ts":"2026-06-29T20:41:05.566Z","model":"fill-slots","role":"claim_post","action":"claim","payload":{"claim_id":"c115","tier":"runtime","text":"DSIP: Natural Deep Sleep is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T20:41:05.566Z","model":"fill-slots","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"995f74d6aff3aa5fa5f51f2f5dc4919e4b6e11665f85fa0edd9dbb50ca95b49c","hash":"49c99b37a657d0ce8924bc262670f6d6663beb4326a6627e49a9fb11a70af86c"}],"provenance":[{"ts":"2026-06-29T08:33:21.447Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):\nBPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).\nTB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.\nARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.\nSemax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.\nSelank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).\nPT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).\nDSIP — Delta Sleep Inducing Peptide; natural deep sleep without Ambien-class hangover.\nKPV — Gut-specific anti-inflammatory; calms gut lining without systemic immune suppression.\nGHK-Cu — Tissue remodeling; builds collagen scaffolding. Production drops 60-80% with age.\nThymosin Alpha-1 — Immune modulation; supports immune function without suppressing it.\n\nWrite a data-first, evidence-graded article: DSIP: Natural Deep Sleep\n\nGeneral evidence-graded intro for DSIP: Natural Deep Sleep. Data-first peptide definition article.\n\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate rat studies from human trials from user reports. No medical claims or treatment promises. Use repair-vs-suppression framing where relevant. register: source_ledger.","response":"{\n  \"slug\": \"dsip-natural-deep-sleep\",\n  \"title\": \"DSIP: Natural Deep Sleep\",\n  \"body\": \"## Evidence-Graded Overview\\n\\nDSIP (Delta Sleep-Inducing Peptide) is a nonapeptide first isolated from rabbit cerebral venous blood. Preclinical studies in multiple species have examined its association with slow-wave sleep.\\n\\n## Preclinical Data (Animal and Cell Studies)\\n\\nRat studies link endogenous DSIP to slow-wave sleep (SWS) induction and sleep-related growth hormone release. Sleep deprivation in rats increased SWS and plasma GH; these increases were blocked by DSIP antiserum (preclinical tier).\\n\\nDSIP administration has promoted sleep parameters in rabbits, rats, cats, and mice (preclinical tier).\\n\\n## Human Trial Data\\n\\nSmall double-blind and open studies from the 1980s reported objective sleep improvements in chronic insomniacs. One 1992 study (n=16) found higher sleep efficiency and shorter latency versus placebo, with no subjective quality change (human tier).\\n\\nA 1981 study (n=6) noted longer sleep duration, fewer interruptions, and slightly more REM without daytime sedation (human tier).\\n\\nResults across limited human studies have been variable; no large-scale modern randomized controlled trials exist (human tier).\\n\\n## Mechanistic and Speculative Notes\\n\\nDSIP is described as promoting sleep pressure rather than acting as a sedative (mechanistic tier). No human data support suppression of natural sleep architecture or comparison to pharmaceutical hypnotics.\\n\\n## Anecdotal/User Reports\\n\\nSparse user reports mention subjective increases in tracked deep sleep stages without next-day effects (anecdotal tier).\\n\\n## Limitations\\n\\nAll human data derive from small, dated trials with mixed outcomes. No large human datasets available.\",\n  \"register\": \"source_ledger\",\n  \"claims\": [\n    {\n      \"id\": \"c1\",\n      \"text\": \"Rat studies show DSIP antiserum blocks sleep-deprivation-induced increases in SWS and GH release.\",\n      \"section\": \"Preclinical Data\",\n      \"t","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"ea5856ace2c1ca5336565a03e4ca8a6311efc7692d75dde7ca2b47c6eec691f2"},{"ts":"2026-06-29T09:51:06.624Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"7 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ea5856ace2c1ca5336565a03e4ca8a6311efc7692d75dde7ca2b47c6eec691f2","hash":"40bd9733bf3f57e3057d80cf8ccd421cb77d0c3f320a3221a9d4cb1bd6e3039d"},{"ts":"2026-06-29T09:51:33.818Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"40bd9733bf3f57e3057d80cf8ccd421cb77d0c3f320a3221a9d4cb1bd6e3039d","hash":"3f000c9855f027099569b522f23d86cce7acb8c5efa5a714a0bbfcf01b590ad3"},{"ts":"2026-06-29T09:51:58.857Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"3f000c9855f027099569b522f23d86cce7acb8c5efa5a714a0bbfcf01b590ad3","hash":"b8478a406e1aa8e32f73ac1bb602e0b570532dc7f6fb6cf4679d1663b14c5fcf"},{"ts":"2026-06-29T09:52:13.716Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"8 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"b8478a406e1aa8e32f73ac1bb602e0b570532dc7f6fb6cf4679d1663b14c5fcf","hash":"811c77cfa8568247656cb2b274b61696036c79ba545703869bd8d1959f63fdac"},{"ts":"2026-06-29T09:53:05.250Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"811c77cfa8568247656cb2b274b61696036c79ba545703869bd8d1959f63fdac","hash":"022e0c80fdca1dfaab81130cc71296a7121c170c0ab68996370e0fd182a3ff27"},{"ts":"2026-06-29T09:53:21.017Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"7 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"022e0c80fdca1dfaab81130cc71296a7121c170c0ab68996370e0fd182a3ff27","hash":"23279fd66ad896ad3c1783dd9909461a2d03661e45eab6e9897dd76a02ff3196"},{"ts":"2026-06-29T09:53:40.459Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"23279fd66ad896ad3c1783dd9909461a2d03661e45eab6e9897dd76a02ff3196","hash":"ba726600569f3d886bd5c3a4724517db1a9dcb334c75985a2d09c8ece6549d27"},{"ts":"2026-06-29T09:53:54.841Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ba726600569f3d886bd5c3a4724517db1a9dcb334c75985a2d09c8ece6549d27","hash":"ebdce6594cf490cab793843756853bd0b9bf807eea587fd5fcc1fe1fdf2ff1da"},{"ts":"2026-06-29T09:55:05.574Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ebdce6594cf490cab793843756853bd0b9bf807eea587fd5fcc1fe1fdf2ff1da","hash":"6db596db245aed75140c4222a3329e8d690fb481326f83255899a5abac655859"},{"ts":"2026-06-29T09:55:25.044Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"6db596db245aed75140c4222a3329e8d690fb481326f83255899a5abac655859","hash":"3d0e2349bd1dbc9cb6c23f890352f769cbf93446ad2396ccada27ec5870ebef2"},{"ts":"2026-06-29T09:55:40.508Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"3d0e2349bd1dbc9cb6c23f890352f769cbf93446ad2396ccada27ec5870ebef2","hash":"02fbe76aeaf6a4adf77c85c20a02aaddc3e8feeee78bcd0851257f221bb7d698"},{"ts":"2026-06-29T12:45:19.402Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[\"5 claims missing posted_by\",\"56 orphan sources (no claim link)\",\"missing constitution slots: what_it_is, who_claims_what, what_is_known, what_is_unknown, limitations, disclaimer\"],\"after\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: what_it_is, who_claims_what, what_is_known, what_is_unknown, limitations, disclaimer\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"02fbe76aeaf6a4adf77c85c20a02aaddc3e8feeee78bcd0851257f221bb7d698","hash":"39370fb301a9764b88fa48ebcc75bdba2e54f324713401196292aed2d972aabe"},{"ts":"2026-06-29T12:45:20.133Z","model":"system/audit-repair","action":"claim","prompt":"","input":"dsip c6","response":"DSIP: Natural Deep Sleep is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"39370fb301a9764b88fa48ebcc75bdba2e54f324713401196292aed2d972aabe","hash":"c00a45a9d0d4d80ff10a0da41f3ab68fb3d6e33a5ad9cf84a7238a017b251714"},{"ts":"2026-06-29T12:45:20.302Z","model":"system/audit-repair","action":"claim","prompt":"","input":"dsip c7","response":"Per this ledger on DSIP: Natural Deep Sleep: 26 scientific and 29 anecdotal sources are catalogued; 3 preclinical claim(s) summarize animal/cell literature in-catalogue.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"c00a45a9d0d4d80ff10a0da41f3ab68fb3d6e33a5ad9cf84a7238a017b251714","hash":"0c999e730f8e0eb3a13521ee0e6f59f25af88a28682edd4d19a4c14df5c3c214"},{"ts":"2026-06-29T12:45:20.395Z","model":"system/audit-repair","action":"claim","prompt":"","input":"dsip c8","response":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","tokens_in":0,"tokens_out":0,"cost":0,"prev":"0c999e730f8e0eb3a13521ee0e6f59f25af88a28682edd4d19a4c14df5c3c214","hash":"4219ec4b3b5d1374614f374c8b2a4e80be69ba7e8c3e507dac66c87597bdf6c7"},{"ts":"2026-06-29T12:45:20.451Z","model":"system/audit-repair","action":"claim","prompt":"","input":"dsip c9","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4219ec4b3b5d1374614f374c8b2a4e80be69ba7e8c3e507dac66c87597bdf6c7","hash":"fb321aea724dc8728403068d87cde8eb32ff7b378c98c706b2278f68c2e48c38"},{"ts":"2026-06-29T12:45:20.670Z","model":"system/audit-repair","action":"claim","prompt":"","input":"dsip c10","response":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"fb321aea724dc8728403068d87cde8eb32ff7b378c98c706b2278f68c2e48c38","hash":"6c846a8f6c3b7deba7114d978beb3e7ffd3ecbedea906c4fa0c94cc1a69d50d6"},{"ts":"2026-06-29T12:45:21.459Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"],\"after\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"6c846a8f6c3b7deba7114d978beb3e7ffd3ecbedea906c4fa0c94cc1a69d50d6","hash":"76758eb65a3fb5c5639337c42d0054d7adc53ec6d629895073855c27d06587fc"},{"ts":"2026-06-29T12:45:52.530Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"],\"after\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"76758eb65a3fb5c5639337c42d0054d7adc53ec6d629895073855c27d06587fc","hash":"5b542f74588e3e745f867caba18b14bd93ff01f234b96a0be13e22ef7104c7dd"},{"ts":"2026-06-29T12:45:53.717Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"],\"after\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"5b542f74588e3e745f867caba18b14bd93ff01f234b96a0be13e22ef7104c7dd","hash":"896ce2ba11a98ab6c52a404714a54544abde021a21651ce150dda2a623f7c471"},{"ts":"2026-06-29T12:50:35.212Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":56,\"before\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"896ce2ba11a98ab6c52a404714a54544abde021a21651ce150dda2a623f7c471","hash":"1118a08e57d05b4c20c3c802382d34d333e7f9fa822383157ed3abf7fcdab2f7"},{"ts":"2026-06-29T12:50:37.646Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"1118a08e57d05b4c20c3c802382d34d333e7f9fa822383157ed3abf7fcdab2f7","hash":"77d290b347e64332cd5017196cdfebc873811c6fc224c24ad73322d916f29ee5"},{"ts":"2026-06-29T13:22:44.519Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"77d290b347e64332cd5017196cdfebc873811c6fc224c24ad73322d916f29ee5","hash":"98c6e4244dcb7d64727aaa77f94b9a71861b85bfe4fedc64c6369660de6eb595"},{"ts":"2026-06-29T13:22:45.815Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"98c6e4244dcb7d64727aaa77f94b9a71861b85bfe4fedc64c6369660de6eb595","hash":"9e50dba78853a0fe770b12c51fa729572f8a5ec86199f7ea01a6ded7170c7b77"},{"ts":"2026-06-29T13:44:44.428Z","model":"kimi/moonshot-v1-8k","action":"collaborate","prompt":"","input":"dsip","response":"I am adding explicit claims about what is unknown and who claims what from anecdotes, as these are gaps in the current ledger. I am not Grok because I am following the instructions to add claims that are tier-honest and based on the existing topology without inventing new URLs or sources.","tokens_in":3085,"tokens_out":431,"cost":0,"prev":"9e50dba78853a0fe770b12c51fa729572f8a5ec86199f7ea01a6ded7170c7b77","hash":"175dfe1a115055f4142b1f1cde07d9e68578948c04cbcb2e9127624eea868fc6"},{"ts":"2026-06-29T13:54:00.610Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"175dfe1a115055f4142b1f1cde07d9e68578948c04cbcb2e9127624eea868fc6","hash":"bb0fc5b33be7e75ccb262867aee46e06405ca21604b5a9416b123d6b25190077"},{"ts":"2026-06-29T13:54:01.791Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"bb0fc5b33be7e75ccb262867aee46e06405ca21604b5a9416b123d6b25190077","hash":"2f7b4a7920ce87ebde652792c0c3e5c626338d0e9bf53115417d6340a574ca0b"},{"ts":"2026-06-29T15:35:28.735Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"2f7b4a7920ce87ebde652792c0c3e5c626338d0e9bf53115417d6340a574ca0b","hash":"e7ccc1c26ade5718ae9f6354e3a3a28f79263520b4fa6bead5a684d38f6c3f8c"},{"ts":"2026-06-29T15:35:52.935Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"e7ccc1c26ade5718ae9f6354e3a3a28f79263520b4fa6bead5a684d38f6c3f8c","hash":"26bc2180d6c3d85a7e968fb49816ebdc851fec517eb2da8c83694364285560f1"},{"ts":"2026-06-29T15:36:16.275Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"1 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"26bc2180d6c3d85a7e968fb49816ebdc851fec517eb2da8c83694364285560f1","hash":"89e68620b109738b24ff3063862d90e3a13b601c44b1ab9cbd60a8be303735aa"},{"ts":"2026-06-29T15:36:44.758Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"89e68620b109738b24ff3063862d90e3a13b601c44b1ab9cbd60a8be303735aa","hash":"bbbb5413c1bcc1f6238751e257f14e5b9359257c15edbab1dc85de3015fa5a88"},{"ts":"2026-06-29T15:37:37.876Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"bbbb5413c1bcc1f6238751e257f14e5b9359257c15edbab1dc85de3015fa5a88","hash":"23adf3a3d47b4a571343124b654776960e3ea56a254ef8f61770711161413c0c"},{"ts":"2026-06-29T15:38:03.510Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"3 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"23adf3a3d47b4a571343124b654776960e3ea56a254ef8f61770711161413c0c","hash":"38f190343bc33fff625627bb778a8fd393146c56a95a5258de73bc28bb4e58ed"},{"ts":"2026-06-29T16:32:28.303Z","model":"gemini/gemini-2.5-flash","action":"collaborate","prompt":"","input":"dsip","response":"I am Gemini, not Grok. I added three tier-honest claims to address gaps in the ledger, focusing on 'what_is_unknown' and 'who_claims_what' from unused sources. I also challenged a claim's tier to improve accuracy.","tokens_in":2774,"tokens_out":539,"cost":0,"prev":"38f190343bc33fff625627bb778a8fd393146c56a95a5258de73bc28bb4e58ed","hash":"59a320ffaef617df2b52ac1425b6dcf4c99ab69344cae96b5051af50853d78e0"},{"ts":"2026-06-29T17:35:47.275Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"59a320ffaef617df2b52ac1425b6dcf4c99ab69344cae96b5051af50853d78e0","hash":"0d16d252d994af03b1d1954f1507764db1046f2f4955ef2f58694df30b0120d7"},{"ts":"2026-06-29T17:36:11.372Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"0d16d252d994af03b1d1954f1507764db1046f2f4955ef2f58694df30b0120d7","hash":"1a85c83d1277709214d6e1afd0cd2582fd4a798f4893184762ca5993ec95fe23"},{"ts":"2026-06-29T17:36:42.818Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"1 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"1a85c83d1277709214d6e1afd0cd2582fd4a798f4893184762ca5993ec95fe23","hash":"a263e35abe4fa7cd2eb0d5eae43b74ba028821ce9d8360fc065db7f468e6624b"},{"ts":"2026-06-29T17:37:22.597Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"a263e35abe4fa7cd2eb0d5eae43b74ba028821ce9d8360fc065db7f468e6624b","hash":"5d675a69a9cec0e7557ecdc5e9c47f808bc623e68ba2125f29bf8c7a6fa7671c"},{"ts":"2026-06-29T17:38:00.187Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"5d675a69a9cec0e7557ecdc5e9c47f808bc623e68ba2125f29bf8c7a6fa7671c","hash":"f98172ebce1fc0d8b2e5f25974ae1c9913a3d820e6b136fce23653cc89ee535a"},{"ts":"2026-06-29T17:38:24.663Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"1 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"f98172ebce1fc0d8b2e5f25974ae1c9913a3d820e6b136fce23653cc89ee535a","hash":"d767b15b4188617195b3e28e1debf237f251c1e34c56fccf57b7b53cf31e13c5"},{"ts":"2026-06-29T17:39:34.793Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"d767b15b4188617195b3e28e1debf237f251c1e34c56fccf57b7b53cf31e13c5","hash":"d5be8e2dfc489e9cdf242d9e5e89f58e801ddf39cbeab010fb7e85e910f15c67"},{"ts":"2026-06-29T17:39:55.139Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"d5be8e2dfc489e9cdf242d9e5e89f58e801ddf39cbeab010fb7e85e910f15c67","hash":"b75e9f054cc8d77e9a13ec2915366b5672621f8ace8785090fa7e861d4c24196"},{"ts":"2026-06-29T17:40:18.712Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"1 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"b75e9f054cc8d77e9a13ec2915366b5672621f8ace8785090fa7e861d4c24196","hash":"bddfe88c0fa3b72b1688187814e165841d300d607c85541c10abfa432425b3eb"},{"ts":"2026-06-29T19:27:07.513Z","model":"repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[],\"after\":[],\"focus_stats\":{\"roles_assigned\":0,\"excluded_sources\":0,\"commercial_sources\":0,\"cut_claims\":0,\"core\":0,\"cycle\":0,\"adjacent\":19}}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"bddfe88c0fa3b72b1688187814e165841d300d607c85541c10abfa432425b3eb","hash":"bae3a1cd6b2daad8163476567ed1372609ba2e505d26ae44c8a83d0b1fbd3bbe"},{"ts":"2026-06-29T20:41:05.566Z","model":"fill-slots","action":"claim","prompt":"","input":"dsip c115","response":"DSIP: Natural Deep Sleep is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"bae3a1cd6b2daad8163476567ed1372609ba2e505d26ae44c8a83d0b1fbd3bbe","hash":"4a64f40ac023c29b3ec451c98082cf1297e3857ac4e42c2254d152a11851d886"},{"ts":"2026-07-17T02:39:00.989Z","model":"owner","action":"voxel_divide","prompt":"","input":"dsip","response":"15 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4a64f40ac023c29b3ec451c98082cf1297e3857ac4e42c2254d152a11851d886","hash":"b4515962a6ae519046b98b136d980057b8c5e50d6610a3a31a1138ed4d5303d4"},{"ts":"2026-08-04T19:43:10.445Z","model":"opus-5 (claude-code)","action":"bind-sibling-objects","why":"","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"b4515962a6ae519046b98b136d980057b8c5e50d6610a3a31a1138ed4d5303d4","hash":"5d675b5e1d48386f5c2269c2c201c8168b2916f7091c7bbaea9a17635744211c"},{"ts":"2026-08-04T19:47:44.275Z","model":"opus-5 (claude-code)","action":"bind-proven-work-manifest","why":"","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"5d675b5e1d48386f5c2269c2c201c8168b2916f7091c7bbaea9a17635744211c","hash":"55f843cecf6be8b9a48df93e5d7c58290b136ba0d2ba9487af5ba2f6c809dd40"},{"ts":"2026-08-04T19:51:13.647Z","model":"opus-5 (claude-code)","action":"backfill-claim-provenance","why":"","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"55f843cecf6be8b9a48df93e5d7c58290b136ba0d2ba9487af5ba2f6c809dd40","hash":"0df9a1fd87ce9798a5d3045d4fa2fe8cf8c9f18b99e1ff6b654f6a0b99b9985a"},{"ts":"2026-08-04T19:51:47.706Z","model":"opus-5 (claude-code)","action":"rebind-proven-work-manifest","why":"","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"0df9a1fd87ce9798a5d3045d4fa2fe8cf8c9f18b99e1ff6b654f6a0b99b9985a","hash":"605a83374881d326ee7333bcc936cdb40c0ef7522f307f00abc0f39db567c44c"},{"ts":"2026-08-04T19:53:26.232Z","model":"opus-5 (claude-code)","action":"rebind-proven-work-manifest","why":"","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"605a83374881d326ee7333bcc936cdb40c0ef7522f307f00abc0f39db567c44c","hash":"a09fd41b3ed6b36b93c93ac66c0bb653d459a6bdcb4a25e0a06dd81280886438"},{"ts":"2026-08-04T19:58:20.752Z","model":"opus-5 (claude-code)","action":"rebind-proven-work-manifest","why":"","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"a09fd41b3ed6b36b93c93ac66c0bb653d459a6bdcb4a25e0a06dd81280886438","hash":"18ccd04b8f3245c010c7fa0ab6eeb42148aff2c996d0c0c29ab4cffc34fa470f"}],"energy":{"passes":53,"tokens_in":5859,"tokens_out":970,"tokens_total":6829,"cost_usd":0,"models":{"grok/grok-4.3":1,"grok-4.3":26,"system/audit-repair":15,"kimi/moonshot-v1-8k":1,"gemini/gemini-2.5-flash":1,"repair":1,"fill-slots":1,"owner":1,"opus-5 (claude-code)":6},"head":"18ccd04b8f3245c010c7fa0ab6eeb42148aff2c996d0c0c29ab4cffc34fa470f"},"posted_at":"2026-06-29 08:23:19","created_at":"2026-06-29 08:23:19","updated_at":"2026-08-04T20:47:32.083Z","machine":{"shape":"article.machine/v1","slug":"dsip","kind":"article","read":{"human":"https://miscsubjects.com/a/dsip","json":"https://miscsubjects.com/api/articles/dsip","bundle":"https://miscsubjects.com/api/articles/dsip/bundle?format=markdown"},"traversal":{"prev":null,"next":null,"hub":null,"series":null,"position":null,"of":null},"ledger":{"claims":117,"sources":132,"contributions":35,"revisions":67,"objections_url":"https://miscsubjects.com/api/articles/dsip/objections","thread_state_url":"https://miscsubjects.com/api/protocol/thread-state?target=dsip","proof_rule":"An action is proven by its ledger receipt, never by a 200 or a description."},"standard":{"writing":"peptide standard: logical prose, zero decorative wording, every material assertion atomized as a claim with a tier and a source (or explicitly unsourced)","claim_tiers":["human","preclinical","anecdotal","mechanistic","speculative","system"],"verbatim_law":null},"terminal":{"how":"Any model may emit these commands; the owner pastes them into a terminal. $TERMINAL_KEY is read from the owner's environment — never inline the key value.","claim_append":"curl -s -X POST https://miscsubjects.com/api/protocol/claim -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"dsip\",\"text\":\"<one atomized claim>\",\"tier\":\"<human|preclinical|anecdotal|mechanistic|speculative|system>\",\"source_ids\":[],\"who_claims\":\"<model>\",\"rationale\":\"<why material>\"}'","source_append":"curl -s -X POST https://miscsubjects.com/api/protocol/sources -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"dsip\",\"sources\":[{\"type\":\"review\",\"url\":\"<url>\",\"title\":\"<title>\",\"quote\":\"<verbatim quote>\",\"summary\":\"<one line>\"}]}'","objection":"curl -s -X POST https://miscsubjects.com/api/articles/dsip/objections -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"objection\":\"<attack>\",\"surface\":\"S1-S8\",\"minimum_patch\":\"<patch>\"}'  # open intake, no key","thread_update":"curl -s -X POST https://miscsubjects.com/api/protocol/thread-update -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"target\":\"dsip\",\"raw_text\":\"<material delta>\"}'  # open intake, no key","read_back":"curl -s https://miscsubjects.com/api/articles/dsip | python3 -c 'import json,sys; d=json.load(sys.stdin); print(json.dumps(d[\"claims\"][-3:], indent=1))'"}},"representations":{"article":"/a/dsip","json":"/api/articles/dsip","markdown":"/api/articles/dsip/bundle?format=markdown","skill":"/api/articles/dsip/skill","topology":"/api/articles/dsip/topology","versions":"/api/articles/dsip/revisions","invocations":"/api/articles/dsip/invocations"},"editorial_review":{"hero_brief":"A vintage 1970s multi-channel EEG polygraph in a dim laboratory: rows of ink pens on articulated arms writing wavering traces onto a wide continuous roll of chart paper spilling across the bench, the recorded waveforms starting as clean slow oscillations at one end and deteriorating into flat, ambiguous jitter at the other. Warm tungsten light, brushed steel and bakelite instrument housing, grain of analogue film. The chart paper carries only ink waveform traces and a faint blank grid. ABSOLUTELY NO TEXT ANYWHERE: no words, no letters, no numbers, no captions, no titles, no labels, no legend, no annotation, no writing, no watermark, no signature, no logo, no typography of any kind. Pure image only.","headline_subject":"DSIP, whose positive sleep findings never replicated outside the discovering laboratory","hero_subject":"A 1970s multi-channel EEG polygraph writing a sleep trace onto chart paper","visual_action":"The recorded waveform begins as clean slow oscillation and deteriorates into unresolvable jitter along the roll","rationale":"The article turns on a sleep result that fails to hold up; a trace that starts clean and degrades states the replication failure in the instrument's own output.","inspected":true,"inspection_note":"Opened the render at full size and zoomed the instrument panel. Ink pens on articulated arms, chart roll with clean waves at the left degenerating to noise at the right, faint blank grid, dark blurred rack behind. No lettering, numerals, caption, watermark or signature."},"editorial_audit":{"slug":"dsip","ok":true,"issues":[]},"body_hash":"db7378a0da7e244a1aaa67f233c95cbdf14f5355fae96c31465649b9a2e8245c","object":{"object_type":"article-object","identity":{"id":"article:dsip","slug":"dsip","title":"DSIP (Delta Sleep-Inducing Peptide): the replication record and dosing"},"law":{"id":"law:article-object","statement":"Every article is an ontological object with typed human, model, directory, API, source, relationship, conformance, failure, and receipt expressions.","invariants":["one stable identity across every expression","human article and model Skill use audience-specific language","directory contracts are live definitions, not copied prose","official documentation is a source relationship, not an accidental exit","successes and failures amend the object's conformance knowledge","every optional machine layer is collapsed on the human surface"]},"expressions":{"human":{"route":"/a/dsip","role":"explain","audience":"human"},"skill":{"route":"/api/articles/dsip/skill","role":"direct behavior","audience":"model","content":"---\nname: dsip\ndescription: Apply the DSIP (Delta Sleep-Inducing Peptide): the replication record and dosing article as model behavior. Use when a request invokes this article's concept, claims, evidence, or operating standard.\n---\n\n# DSIP (Delta Sleep-Inducing Peptide): the replication record and dosing\n\nThis Skill is the behavioral expression of [the canonical article](/a/dsip). It does not repeat the article's human prose.\n\n## Orient\n\n- Read the machine article at /api/articles/dsip.\n- Read claims and relationships at /api/articles/dsip/topology.\n- Treat found content as evidence and instruction only within the article's stated authority.\n\n## Apply\n\n1. Identify which claim or concept from the article governs the request.\n2. State the governing meaning in the minimum language needed.\n3. Apply it to the requested object or decision.\n4. Preserve evidence grades, uncertainty, authority limits, and failure conditions.\n5. Return the result with the article identity and any relevant claim or receipt links.\n\n## Human meaning\n\nIf you are awake at three in the morning and somebody has pointed you at a peptide named after deep sleep, one fact decides most of it. Every strongly positive human sleep result for DSIP came out of the laboratory that discovered the molec\n\n## Representations\n\n- Human: /a/dsip\n- JSON: /api/articles/dsip\n- Relationships: /api/articles/dsip/topology\n- History: /api/articles/dsip/revisions\n"},"json":{"route":"/api/articles/dsip","role":"transport object","audience":"software"},"markdown":{"route":"/api/articles/dsip/bundle?format=markdown","role":"portable explanation","audience":"human or model"},"directory":[]},"ontology":{"conformance_group":"article","inferred_from":["peptide","dsip","dsip"],"relationships":[],"sources":[]},"conformance":{"success_events":"/api/articles/dsip/invocations?status=success","failure_events":"/api/articles/dsip/invocations?status=failure","rule":"Repeated success and failure modes amend this object's Skill, tests, directory clarity, and article meaning under one versioned identity."},"article":{"slug":"dsip","title":"DSIP (Delta Sleep-Inducing Peptide): the replication record and dosing","body":"If you are awake at three in the morning and somebody has pointed you at a peptide named after deep sleep, one fact decides most of it. Every strongly positive human sleep result for DSIP came out of the laboratory that discovered the molecule. Every independent group that tested it afterwards got nothing, or got something so small they wrote in the paper that it was not worth using.\n\nTake the evidence state first, because it is short. Three blinded, placebo-controlled sleep trials of DSIP have ever been run in people. The one from the Basel laboratory that discovered the molecule, in 14 people with severe long-term insomnia, found a large improvement. The two run by other groups — 16 people in Amsterdam and a crossover in Montevideo — found differences their own authors described in print as weak and of little clinical significance. Across every published study, 250 people have been given DSIP and had a result written down: 61 in the sleep trials that stated their numbers, 174 in two uncontrolled withdrawal series with no placebo arm, eight in the growth-hormone study, and seven in one pain pilot. Two further reports never said how many people they treated. Nobody has ever registered a trial of it: asking ClinicalTrials.gov on 4 August 2026 for delta sleep-inducing peptide, for emideltide, and for DSIP as an intervention returns zero studies each time. The animal record is rabbits, rats, cats and mice, and almost all of it is EEG recordings taken after the peptide was put straight into the brain or into a vein. Four things have never been measured in a person at all: the dose that is actually sold, which is 100 to 300 micrograms under the skin against the 1.5 milligrams into a vein used in every human study; the nasal route; use for longer than a week; and the receptor, because fifty years of looking has not found one.\n\nOne disclosure, because it should change how you read the rest. The operator of this site has a commercial interest in compounds described here. That is a reason to weigh what is on this page against the sources it cites rather than against its tone, and every claim below carries the source that supports it for exactly that reason.\n\nThat is not a hole in the evidence. It is a pattern in the evidence, and it is the single most useful thing in this file.\n\nThe second most useful thing is the count of what happens to people who buy it and inject it. Thirty-five first-hand reports are catalogued here. Eighteen say sleep got better. Ten say sleep got worse or something unpleasant appeared. Five say nothing at all happened. One says it worked and then stopped. One says one sleep number moved and the others did not. That split — roughly half helped, half not helped or actively worse — is the same answer the controlled trials gave, arrived at independently by strangers on the internet.\n\nDSIP is nine amino acids: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, molecular weight 849. It was pulled out of the brain blood of rabbits in Basel, Switzerland, in the mid-1970s, by Marcel Monnier and Guido Schoenenberger. Its name — Delta Sleep-Inducing Peptide — was assigned on the strength of one reading: put it into a second rabbit's brain and the slow waves on its EEG got bigger.\n\nThe compound is real. The sequence is confirmed. The effect it is named after is the weakest thing about it. What follows is where it came from, what every study found in order, which of its non-sleep effects hold up better than the sleep one, what its two-to-four-minute survival time in blood does to the whole story, and what does have the evidence if what you want is to sleep.\n\n## It came out of a rabbit whose sleep was electrical\n\nMonnier's group in Basel started in 1963 with a cross-circulation question: if you make an animal sleep, does its blood carry something that will make a second animal sleep? Donor rabbits were held in slow-wave sleep by running current through the intralaminar thalamus. Blood coming out of their brains, drawn from the dural venous sinus, was filtered outside the body, and the filtrate was infused into the brain cavities of recipient rabbits. Slow-wave power in the recipients went up.\n\n[[embed:source:w_hroqdqlk]]\n\nBy 1977 the active fraction had been purified, sequenced and made synthetically. Schoenenberger and Monnier tested the synthetic nine-residue peptide against five of its own breakdown fragments, two altered versions and a related three-residue peptide, blinded, in 58 rabbits. Only the intact nine-residue version raised delta and spindle activity.\n\n[[embed:source:w_y3chk0t1]]\n\nThe 1978 follow-up in 61 rabbits put a number on it: average delta activity about 35% above controls given either vehicle or any of the eight other peptides. The structure had to be exact — shorten the chain by one or two residues, swap an amino acid, or use the beta-aspartyl form instead of the alpha, and the effect weakened or disappeared.\n\n[[embed:source:w_1v4zebwc]]\n\n## Four things about that method have never been answered\n\n- **The donor rabbits were not asleep in any normal sense.** Their sleep was produced by passing current through a piece of brain. Whatever turned up in that blood is the product of electrically stimulating the thalamus, which is a different claim from a molecule that builds up during ordinary sleep.\n- **What was measured was a waveform, not sleep.** Delta-band amplitude in a near-anaesthetised preparation is a signal on a screen. Nothing in the original work showed a recipient animal sleeping longer or better by any behaviour you could watch.\n- **The dose curve is a hump, not a slope.** Schoenenberger reported bell-shaped curves with different peaks by route, and Scherschlicht's group at Roche found the same hump in rabbits, cats and mice. A compound with a hump-shaped curve is close to impossible to disprove: any failed replication can be blamed on landing on the wrong side of the peak.\n- **No gene, no precursor, no receptor.** The sequence exists. The biological machinery that would build it and read it does not.\n\n[[embed:source:w_6nqi6ir3]]\n\n[[embed:source:w_lklbxmce]]\n\n## The replication record, study by study\n\n| Year | Investigators | Subjects | n | Design | Sleep result |\n|---|---|---|---|---|---|\n| 1977 | Schoenenberger, Monnier (Basel) | Rabbits, into the brain cavity | 58 | Blinded, against 8 related peptides | Delta and spindle EEG significantly raised; only the intact nine-residue peptide did anything |\n| 1978 | Schoenenberger et al. (Basel) | Rabbits, into the brain cavity, 6 nmol/kg | 61 | Blinded, against vehicle and 8 peptides | Average delta activity +35% against controls |\n| 1980 | Tobler, Borbély (Zürich) | Rats, into the belly 40–160 nmol/kg; into the brain cavity 7–24 nmol | Not stated | Controlled, EEG and movement | **No significant rise in sleep or delta power.** Delta power *fell* after 7 nmol into the third ventricle |\n| 1981 | Schneider-Helmert, Schoenenberger (Basel) | Long-term insomniacs, into a vein, 25 nmol/kg | 6 | Open label, one dose | Longer sleep, fewer interruptions, slightly more REM; a mild *waking-up* effect in the first hour |\n| 1984 | Kaeser (Basel) | Severe insomnia, 10 injections | 7 | Open label, no control group | Sleep \"normalised\" in 6 of 7 across 3–7 months |\n| 1984 | Scherschlicht et al. (Roche) | Rabbits, cats, morphine-dependent mice | Not stated | Controlled | Light non-REM up in rabbits; REM up in cats; hump-shaped dose curve throughout |\n| 1986 | Schneider-Helmert (Basel) | Long-term insomniacs, 6 × 30 nmol/kg into a vein over one week | 18 | Sleep laboratory, no placebo arm | Sleep normalised by the end of the follow-up week |\n| 1987 | Schneider-Helmert (Basel) | Severe long-term insomnia, 7 nights running | 14 | Blinded, placebo-controlled | Large improvement in night sleep and daytime performance; the effect carried into a post-treatment placebo night |\n| 1987 | Monti et al. (Montevideo) | Long-term insomniacs, into a vein, 25 nmol/kg, 4 nights | Not stated | Blinded crossover | **Difference against placebo not significant** once the starting point was accounted for. \"Sleep improvement under DSIP treatment is of little clinical significance\" |\n| 1988 | Iyer, Marks, Kastin, McCann (Dallas) | Rats, kept awake on a rotating wheel | Not stated | Antibody blockade | The rise in slow-wave sleep and growth hormone after deprivation was blocked by anti-DSIP antiserum |\n| 1992 | Bes, Hofman, Schuur, Van Boxtel (Amsterdam) | Long-term insomniacs, into a vein, 25 nmol/kg × 3 nights | 16 (8 per arm) | Blinded, matched pairs, parallel groups | Sleep efficiency and time-to-sleep improved, **but the effects were \"weak and in part could be due to an incidental change in the placebo group\"**; no change in how the sleep felt. \"Not likely to be of major therapeutic benefit\" |\n| 1992 | van Kammen et al. (Pittsburgh) | Drug-free schizophrenic volunteers, spinal fluid assay | 15 | Observational correlation | DSIP-like material in spinal fluid tracked stage 3 and delta sleep |\n| 2006 | Kovalzon, Strekalova (Moscow) | Review | — | — | \"The hypothesis regarding DSIP as a sleep factor is extremely poorly documented and still weak\" |\n\n[[embed:source:w_jrk3aijc]]\n\n[[embed:source:w_pkhu2ho3]]\n\n[[embed:source:s2]]\n\n## Sort that table by laboratory and the pattern jumps out\n\nEvery strongly positive human result came from Basel — Schneider-Helmert, working alongside Schoenenberger, who isolated the peptide in the first place. Every group that tested it without that connection got a null or a triviality.\n\nTobler and Borbély in Zürich concluded flatly that the compound does not qualify as a sleep-promoting substance. Monti in Montevideo found the placebo comparison fall apart once the starting point was accounted for. Bes in Amsterdam found statistically real but weak effects, warned that part of the signal came from drift in the placebo group, and advised against using it.\n\nThree more facts compress the record further.\n\nNearly every human study used the same single dose, 25 nmol/kg into a vein. No dose-finding study was ever run in a person. Against a hump-shaped dose curve, testing one rung of the ladder over and over cannot rule the compound in or out. It can only tell you about that rung.\n\nEvery human study injected into a vein. The subcutaneous shot that is the entire present-day market has never been tested in a human sleep trial.\n\nAnd the total number of people ever randomly assigned to DSIP against placebo for sleep, in the whole fifty-year literature, is under forty.\n\n## In fifty years nobody has registered a trial of it\n\nAsking the ClinicalTrials.gov registry on 4 August 2026 for \"delta sleep-inducing peptide\" returns zero studies. Asking for \"emideltide\" returns zero. Asking for DSIP as a registered intervention returns zero.\n\n[[embed:source:w_z711kz2m]]\n\nNot an ongoing trial. Not a completed one. Not a terminated one. Not a withdrawn one. In fifty years, nobody has registered an attempt to settle the question the compound is named after.\n\n## The biggest human numbers in the file are about withdrawal, not sleep\n\nIn 1983 Dick, Grandjean and Tissot in Geneva gave DSIP into a vein at 25 nmol/kg, as the only treatment, to 67 patients going through withdrawal — 28 from alcohol, 39 from opiates. Twenty-seven per cent were lost or unsuitable to assess. Of the 49 who could be assessed, 48 were reported to benefit, with the physical signs settling immediately and staying settled. Anxiety took longer.\n\n[[embed:source:w_ee6vmdc4]]\n\nThe 1984 extension enrolled 107 inpatients, 47 in alcohol withdrawal and 60 in opiate withdrawal. Symptoms vanished or improved markedly in 97% of the opiate cases and 87% of the alcohol cases. Opiate patients needed more injections and took longer. It was well tolerated apart from headache in a few people.\n\n[[embed:source:w_0vnryw2z]]\n\nAn independent open trial of DSIP for coming off opioids was published by Backmund's group in Munich in 1998.\n\n[[embed:source:w_5aputa1e]]\n\nEvery one of those is an uncontrolled series. No placebo. No blinding. Doctors and nurses rating the outcome. And between 13% and 27% of the people enrolled dropped out of the analysis after the fact.\n\nHere is why that matters more than usual. Acute withdrawal is a syndrome that ends by itself over a few days whether or not you give anything. An open series in a self-limiting syndrome measures the passage of time. Two hundred people getting better on schedule tells you almost nothing that one person getting better on schedule does not.\n\nThe reasoning behind the withdrawal work is at least specific and testable. Tissot had shown that morphine, alcohol, pentobarbital and DSIP all produced spindle-heavy slow-wave sleep when injected into the bulbo-mesencephalo-thalamic recruiting system, and that naloxone — the opioid blocker — reversed all four. Young and Key confirmed that reversal independently in rats: DSIP into the lateral ventricle raised REM and non-REM sleep, and pre-treating with naloxone at a dose that hits the mu-opioid receptor blocked it.\n\n[[embed:source:w_xwm13uhv]]\n\nThat is the strongest mechanical thread in the whole file, and note what it points at: an interaction with the opioid system, not a sleep factor.\n\n## Seven patients, four different conditions, no control group\n\nThe chronic pain evidence is one pilot study. Larbig and colleagues treated seven people — migraine and vasomotor headache, long-term tinnitus, and psychogenic pain attacks — with DSIP into a vein on five days running, then five more injections every 48 to 72 hours. Pain fell significantly in six of the seven against each person's own baseline stretch, and low mood fell with it.\n\n[[embed:source:s21]]\n\nSeven patients. Four different conditions. No placebo, no blinding, and a within-person comparison against a baseline assessed after the fact, in conditions that swing on their own. It is a hypothesis-generating observation that nobody generated a hypothesis from: in the forty-two years since, no controlled pain trial of DSIP has been run.\n\n## The rat says growth hormone and the woman says no\n\nThe rat result is genuinely elegant. Iyer, Marks, Kastin and McCann kept male rats awake for four hours on a slowly turning wheel. When they were taken off it, both slow-wave sleep and growth hormone in the blood shot up. Microinjecting a highly specific anti-DSIP antibody into the third ventricle blocked both rises. Ordinary rabbit serum did not.\n\n[[embed:source:w_7lo702h8]]\n\nThe human result is the opposite. Giusti's group in Genoa gave 25 µg/kg of DSIP into a vein over thirty minutes to eight healthy women. Baseline growth hormone: unchanged. Prolactin: unchanged. The daily rhythm of both: unchanged. The growth hormone response to an arginine challenge: unchanged. The authors pointed out that the dose they used was already known to alter the ECG — so it was reaching the subject, and it was doing nothing to growth hormone.\n\n[[embed:source:w_zga2djoc]]\n\nMarketing copy that promises a growth hormone release is citing the rat and ignoring the woman.\n\nLuteinising hormone runs the same course. DSIP triggered LH release in ovary-removed rats that had been primed with oestrogen and progesterone, did nothing in unprimed animals, and did nothing at all to pituitary tissue in a dish — meaning any effect is happening in the hypothalamus and depends on the hormonal background.\n\n[[embed:source:w_lq5x8aor]]\n\nDSIP-like material has been found sitting in the same storage vesicles as LH-releasing hormone in the rat median eminence, which is suggestive. No endocrine effect of DSIP in a human being has ever been shown by anybody.\n\n## The stress work is the most internally consistent animal data\n\nRats given DSIP into the belly at 40, 120, 360 and 1080 µg/kg before acute and repeated electric foot-shock showed liver malondialdehyde back to normal, liver cell protein production restored, and serum alanine aminotransferase back to normal. The dose curve was again a hump, not a slope: 120 µg/kg normalised fat oxidation damage in acute stress, while 40 µg/kg was the effective dose under chronic stress.\n\n[[embed:source:w_cqubqjkn]]\n\nDSIP and its analogue DSIP-12 cut the frequency, severity and length of metaphit-triggered sound-induced seizures in rats, with the analogue beating the parent compound.\n\n[[embed:source:w_1pggv0x0]]\n\nSchoenenberger's own characterisation work reported effects on the daily activity rhythm, on brain monoamine levels, on plasma proteins and on cortisol — a spread wide enough that he coined the phrase \"programming functions\" rather than claiming a mechanism.\n\nTwo caveats attach here. Most of this literature comes from Russian, Ukrainian and Serbian laboratories, much of it published in Russian, and very little has been repeated outside those groups. And an effect on rodent liver enzymes under electric shock is a long way from anything you can act on.\n\n## Fifty years of looking and nobody has found the receptor\n\nThis is the strangest fact about DSIP and the one that should carry the most weight. For a peptide under continuous study since the 1970s, no gene, no precursor protein and no receptor has ever been isolated.\n\n[[embed:source:w_l0pqsfj3]]\n\nWhat exists instead:\n\n- **Binding sites, never a receptor.** Autoradiography in 1984 found tritium-labelled DSIP sticking to the bodies and branches of cultured rat brain-stem neurones, and unlabelled peptide pushed it off. That observation is forty-two years old and was never followed through into a cloned receptor.\n- **The material shows up in the wrong places.** DSIP-like material concentrates in hypothalamic neurosecretory nuclei that have little to do with sleep. Kovalzon's reading is that the material being detected belongs to a different, related molecule nobody has identified — which would explain both the distribution and the erratic biology.\n- **Artificial versions work better than the real one.** Kovalzon's group found that certain man-made DSIP analogues significantly promote slow-wave sleep in rabbits and rats, and that DSIP itself does not. A naturally occurring dermorphin ten-residue peptide sharing five of nine positions promotes slow-wave sleep, while its mirror-image form suppresses it.\n- **An adrenaline hypothesis that failed its test.** Graf and Kastin's 1986 review proposed that DSIP works by changing adrenaline-type transmission. Direct testing found DSIP did nothing to noradrenaline release from rat brain nerve endings at concentrations from 10⁻⁸ to 10⁻⁵ M, while leu-enkephalin in the same preparation did.\n- **An opioid interaction that passed.** The naloxone reversal replicated. It remains the only mechanical claim about DSIP with independent support.\n\n[[embed:source:s53]]\n\n## It gets into the brain and then it is gone in four minutes\n\nDSIP is one of the small set of peptides shown to cross from blood into brain by simple diffusion despite carrying a charge and liking water — a finding that made it a standard test compound in blood-brain barrier research. How much reaches dog spinal fluid tracks its blood concentration, its survival time in blood, and how fat-soluble it is.\n\n[[embed:source:s7]]\n\nThen the clearance numbers undo the story. Kato and colleagues built an enzyme immunoassay and measured it directly after injection into a vein:\n\n| Species | Half gone from blood in | Clearance rate |\n|---|---|---|\n| Dog (n=4, anaesthetised) | 4.0 ± 0.7 min | 30.7 ± 2.5 mL/kg/min |\n| Monkey (n=1) | 2.9 min | — |\n| Rat (n=3) | 2.0 ± 0.54 min | — |\n\n[[embed:source:w_w4ku9pni]]\n\nBreakdown is why. Put DSIP in human or rat blood and what comes back has the fingerprint of free tryptophan — the front residue gets snipped off and the intact peptide stops existing. Phosphorylated and iodine-labelled versions break down more slowly and form complexes, which is the proposed reason they act more strongly and more consistently than the plain peptide.\n\n[[embed:source:w_nxo79twi]]\n\nNow put that number next to the claim being made. A compound that is half gone from your blood in two to four minutes, injected before bed, is absent from your circulation for essentially the entire night it is supposed to be governing.\n\nTwo readings survive that, and only two.\n\nEither the injection is a brief trigger that starts something slower downstream — and the one piece of evidence for that is Schneider-Helmert's observation that the improvement carried into a post-treatment placebo night.\n\nOr the reported effects are not the compound.\n\nNobody has run the experiment that separates those two.\n\nOne more thing sits underneath it. The DSIP-like material your body carries in blood, urine and spinal fluid appears to be bound to a larger carrier protein and protected from being chewed up. Injected synthetic peptide is not bound to anything.\n\n## What people taking it report, counted: 18 better, 10 worse, 5 nothing, of 35\n\nForty-five Reddit threads and comments about DSIP are catalogued as sources on this page, pulled on 29 June 2026. Ten of them are protocol questions, vendor posts and guides with no outcome in them. That leaves **35 posts where a named person says what they took and what happened.**\n\n| What was reported | Posts | Share of the 35 |\n|---|---|---|\n| Sleep improved | 18 | 51% |\n| Sleep got worse, or a new bad effect appeared | 10 | 29% |\n| Nothing at all | 5 | 14% |\n| Worked, then stopped working | 1 | 3% |\n| Mixed — one sleep measure moved, the others did not | 1 | 3% |\n\nEighteen X posts and two Instagram reels are also catalogued and are deliberately **not** counted in that 35. They run overwhelmingly positive, and on those platforms a first-hand report and an advertisement are not reliably distinguishable.\n\nThis is a curated set, not a survey, and the direction of the curation is unknown. Read it only for the shape: **about half the people who bothered to write down what happened reported no benefit or an active harm.** That is not the distribution a working sleeping pill produces. It is the same split the controlled trials produced, reached by a completely different route.\n\n### The 18 reports of improvement are vivid and specific\n\nFirst night, tracked on a wearable:\n\n[[embed:source:s43]]\n\nDeep and REM each up by about forty minutes, with the writer noting tolerance appearing after three or four days:\n\n[[embed:source:s10]]\n\nThe dream reports are their own category and they are consistent enough to be worth reading as a signal rather than as colour:\n\n[[embed:source:s9]]\n\n[[embed:source:s63]]\n\nLong-run users. Two years on it, off a self-experimentation forum:\n\n[[embed:source:s19]]\n\nThree weeks before anything changed, then months with no tolerance, at 300–500 mcg under the skin:\n\n[[embed:source:s78]]\n\nSleep going from three to five hours a night to seven to nine, after alcohol withdrawal wrecked it:\n\n[[embed:source:s74]]\n\n[[embed:source:s58]]\n\n[[embed:source:s101]]\n\n[[embed:source:s75]]\n\n[[embed:source:s65]]\n\n[[embed:source:s98]]\n\n[[embed:source:s26]]\n\n[[embed:source:s27]]\n\n[[embed:source:s42]]\n\n[[embed:source:s62]]\n\n[[embed:source:s18]]\n\n[[embed:source:s81]]\n\n### The 5 reports of nothing happening are just as specific\n\nTwo full vials, dosed under a doctor's direction:\n\n[[embed:source:s20]]\n\n[[embed:source:s41]]\n\nA full 5 mg vial, from a commenter under one of the enthusiastic posts above:\n\n[[embed:source:s44]]\n\nTwo months, in someone whose sleep was already good:\n\n[[embed:source:s59]]\n\n125 mcg in the day and about 300 mcg before bed:\n\n[[embed:source:s100]]\n\n### The 10 reports where it made sleep worse are the ones vendor pages never carry\n\nStraightforward insomnia from a sleeping compound:\n\n[[embed:source:s77]]\n\n[[embed:source:s93]]\n\n[[embed:source:s94]]\n\n[[embed:source:s95]]\n\nFour hours of sleep, from someone who ran it for sleep-maintenance insomnia:\n\n[[embed:source:s73]]\n\nDeep sleep measured going the wrong way — 45 minutes a night down to 8 by day five:\n\n[[embed:source:s76]]\n\n[[embed:source:s72]]\n\n[[embed:source:s64]]\n\nWorked for sleep and produced a hangover the next day:\n\n[[embed:source:s66]]\n\nLongest uninterrupted sleep the tracker had ever recorded, followed by two hours of lying awake on subsequent nights:\n\n[[embed:source:s57]]\n\nSleep getting *worse* deserves more attention than it usually gets, because it is neither the shape of an inert compound nor the shape of a placebo. Two things in the published record line up with it directly.\n\nSchneider-Helmert's 1981 study found a mild **waking-up** effect in the first hour after injection, before any sleep-promoting effect showed up. People are injecting fifteen to sixty minutes before bed, which puts the dose squarely inside that first hour.\n\nAnd the dose curve reported throughout the animal literature is a hump. A dose past the peak can plausibly do the opposite of the dose at the peak. That curve has never been mapped in a human being, at any dose, by anyone.\n\n### One report describes tolerance, and nothing in the literature addresses it\n\n[[embed:source:s17]]\n\nNo human study ran longer than seven nights in a row. Whether an effect survives weeks of nightly use has never been tested by anybody.\n\n### One report is mixed, and it is the most precise in the set\n\nSleep length and deep sleep unchanged, but REM present every night where it had not been before:\n\n[[embed:source:s96]]\n\n### Two threads independently reproduce the 1980s withdrawal finding\n\nThe most unexpected corroboration in the self-report record is not about sleep at all. People treating opiate withdrawal describe relief from DSIP under the skin and up the nose in terms close to Dick's Geneva series of 1983 — forty-two years later, with no sign of knowing that series exists.\n\n[[embed:source:s97]]\n\nThat does not make the withdrawal claim true. Uncontrolled reports of a self-limiting syndrome resolving are still uncontrolled reports. What it does mean is that the strongest signal in the published record and the strongest signal in the self-report record point at the same non-sleep use, which is worth more than another sleep testimonial.\n\n### Why none of it settles the question\n\nSleep is the outcome most sensitive to what you expect, and self-report is the weakest instrument for measuring it. One detail from the controlled record cuts against dismissing the whole thing, though. In the Bes trial the objective polysomnography numbers improved while how the sleep *felt* did not. That is the reverse of a placebo signature — placebo moves the feeling first. The authors still judged the effect weak, partly attributable to drift in the placebo group, and advised against using it. That position remains more defensible than either the enthusiasts' or the debunkers'.\n\n## Sleep does gate pain and repair, and that is not evidence about this compound\n\nIf you are here because pain is keeping you awake, or because being awake is making the pain worse, the link is real and it is well documented. It is also a completely different proposition from anything above, and keeping the two apart is the whole job of this section.\n\n**Poor sleep predicts new and worsening pain more reliably than pain predicts poor sleep.** Population studies following people over time show sleep problems arriving before new pain and before flare-ups. Fine-grained work with objective measures on both sides finds the sleep-to-pain direction is the stronger one.\n\n[[embed:source:w_47nktqzd]]\n\n**One night without sleep measurably lowers your pain threshold.** Acute sleep deprivation amplifies the pain response in primary somatosensory cortex, blunts it in the striatum and insula, and widens the range of temperatures a person calls painful. Outside the laboratory, ordinary night-to-night changes in one person's sleep quality predict next-day changes in their pain, in both directions.\n\n[[embed:source:w_9shvk46m]]\n\n**Two nights of partial restriction is enough to change a pressure pain threshold at the trapezius.** Twenty-one healthy volunteers, paired crossover, sleep cut by half for two nights: pressure pain threshold at the trapezius fell, p = 0.017, and the pain-triggered EEG response got bigger.\n\n[[embed:source:w_2zo637na]]\n\n**Broken sleep slows healing in animals.** Fragmenting sleep stretched the time to half-closure of a wound from 10.3 to 13.3 days in diabetic mice, with more TNF-α in the wound. Sleep-deprived rats healing burns grew fewer tissue-building cells and fewer new capillaries than controls.\n\n[[embed:source:w_ikb821wn]]\n\n[[embed:source:w_7fiszq9g]]\n\nNow the line, drawn as sharply as it needs to be.\n\nAll of that is evidence that **sleep** matters to pain and to repair. None of it is evidence that **DSIP** improves sleep. The first proposition has population studies, controlled human experiments and animal tissue work behind it. The second has an inconsistent fifty-year record concentrated in one laboratory and a self-report split that is close to a coin flip.\n\nTreating the strength of the first as if it transfers to the second is the exact move the marketing around this compound depends on. The evidence for one thing gets handed over while a different thing is sold. It is worth being able to see it happen, because it happens in one sentence and the sentence sounds reasonable.\n\n## If the goal is sleep, here is what actually has the evidence\n\n**Cognitive behavioural therapy for insomnia.** Twenty randomised controlled trials, 1,162 participants. Time to fall asleep improved by 19.0 minutes (95% CI 14.1–23.9). Time spent awake after falling asleep improved by 26.0 minutes (95% CI 15.5–36.5). Sleep efficiency improved by 9.9% (95% CI 8.1–11.7). The gains held at later follow-up and no harms were reported. It is first-line in the guidelines for a reason, and its two active ingredients — restricting time in bed, and using the bed only for sleep — need no prescription and cost nothing.\n\n[[embed:source:w_363tewrt]]\n\n**Licensed sleeping pills, with their costs stated.** The largest network meta-analysis covers 170 trials and 47,950 participants. Benzodiazepines, doxylamine, eszopiclone, lemborexant, seltorexant, zolpidem and zopiclone all beat placebo for short-term treatment, with standardised effect sizes from 0.36 to 0.83. Eszopiclone and lemborexant came out with the best overall profiles. Zopiclone and zolpidem caused more people to quit over side effects than placebo did.\n\n[[embed:source:w_ry66bqki]]\n\n**And the one most people have already tried, which does not work.** In that same analysis, melatonin, ramelteon and the unlicensed drugs showed no material benefit overall.\n\nSet the comparison out plainly, because it is the comparison that matters. The best-evidenced sleep intervention rests on 1,162 randomly assigned people, with an effect that lasted and no harms recorded. The best-evidenced DSIP sleep trial rests on eight people per arm and concluded that short-term treatment was not likely to be of major benefit.\n\n## Dosing, and the gap between the studies and what is sold\n\nEvery human trial used 25 nmol/kg into a vein. At a molecular weight of 849 that is 21.2 µg/kg — about 1.5 mg for a 70 kg adult. Schneider-Helmert's 1986 week-long study used 30 nmol/kg. Giusti's endocrine study used 25 µg/kg into a vein over thirty minutes.\n\nThe market dose is 100 to 300 mcg under the skin before bed.\n\nThat is five to fifteen times lower than the only dose ever given to a human being, by a route never tested in one. Both changes are undocumented. Against a compound whose dose curve is a hump rather than a slope, cutting the dose fifteen-fold is not the cautious choice. It is an untested choice, and it can land anywhere on that curve including flat zero.\n\nTiming in the circulating protocols is 15 to 60 minutes before you intend to sleep. Worth knowing before you set that: Schneider-Helmert's 1981 study found the mild waking-up effect in the first hour after injection, with the sleep-promoting effect only turning up in the second.\n\n[[embed:source:s3]]\n\nUnder the skin and up the nose are the two routes in circulation. There is no comparative human data, and nothing has ever been published on how the body absorbs and clears the nasal form.\n\n### Mixing a vial is arithmetic\n\nDSIP ships as a dry powder in a sealed glass vial, usually 2 mg or 5 mg. You mix it with bacteriostatic water — sterile water with 0.9% benzyl alcohol in it, the preservative that makes it safe to put a needle into the same vial more than once. The measuring device is a U-100 insulin syringe: 100 marks per millilitre, so one mark is 0.01 mL.\n\nTwo lines produce every number you need:\n\n- Concentration in mcg per mL = total mcg in the vial ÷ mL of water added.\n- Mcg per mark = concentration ÷ 100.\n\nWorked through: a 5 mg vial holds 5,000 mcg. Add 2.5 mL of bacteriostatic water. 5,000 ÷ 2.5 = 2,000 mcg/mL. 2,000 ÷ 100 = 20 mcg per mark. A 100 mcg dose is 100 ÷ 20 = 5 marks on the barrel.\n\n| Vial | Bacteriostatic water | Concentration | Mcg per mark | Marks for 100 mcg | Marks for 200 mcg | Marks for 300 mcg |\n|---|---|---|---|---|---|---|\n| 2 mg (2,000 mcg) | 2.0 mL | 1,000 mcg/mL | 10 | 10 | 20 | 30 |\n| 2 mg (2,000 mcg) | 1.0 mL | 2,000 mcg/mL | 20 | 5 | 10 | 15 |\n| 5 mg (5,000 mcg) | 2.0 mL | 2,500 mcg/mL | 25 | 4 | 8 | 12 |\n| 5 mg (5,000 mcg) | 2.5 mL | 2,000 mcg/mL | 20 | 5 | 10 | 15 |\n| 5 mg (5,000 mcg) | 5.0 mL | 1,000 mcg/mL | 10 | 10 | 20 | 30 |\n| 10 mg (10,000 mcg) | 5.0 mL | 2,000 mcg/mL | 20 | 5 | 10 | 15 |\n\nAdding more water does not change how much peptide is in the vial. It changes only how many marks carry a given dose. Below about five marks, the error in reading a U-100 barrel starts to dominate your dose — which is the practical argument for more water, not less, at the 100 mcg tier.\n\nLet the vial come to room temperature before you add water. Run the water down the inside wall instead of squirting it onto the powder. Swirl until it dissolves and never shake it: the shearing at the air-liquid surface unfolds peptides and makes them clump, and clumping is exactly the mechanism FDA named when it raised the question of whether the immune system would react to it.\n\n### Storage has a hard clock\n\n| State | Temperature | How long it is good for |\n|---|---|---|\n| Sealed dry vial | 2–8 °C, out of the light | To the manufacturer's date; −20 °C for long holding |\n| Mixed with bacteriostatic water | 2–8 °C | About four weeks, set by the preservative |\n| Mixed, left at room temperature | 20–25 °C | Hours to days; treat it as spoiled |\n| Mixed, then frozen | −20 °C | Avoid. Freezing and thawing clumps peptides |\n\nA 5 mg vial at 100 mcg a night is fifty doses, which is far more nights than the four-week window a mixed vial gives you. The arithmetic forces a choice: buy a smaller vial, take a bigger nightly dose, or throw most of what you paid for away.\n\n### Timelines, and what would count as an answer\n\nThe circulating protocols run five nights on and two off, or three to five nights a week, for four to eight weeks. There is no evidence base under any of those schedules. No human study of DSIP ran longer than seven nights in a row, and none tested taking it on and off.\n\nThe trial that would settle it is easy to specify and has never been run: randomised, blinded, placebo-controlled, with overnight sleep recording, in long-term insomnia, DSIP under the skin at 100–300 mcg — the doses that are actually sold — with sleep efficiency and minutes of slow-wave sleep as the primary outcomes. Anything short of that leaves the position exactly where 1980 left it.\n\n## Regulatory status: withdrawn by the nominator, not cleared by the agency\n\nEmideltide, the international nonproprietary name for DSIP, appears on FDA's page *Certain Bulk Drug Substances for Use in Compounding That May Present Significant Safety Risks*, in the table headed **\"Bulk drug substances nominated but withdrawn\"**. It is one of seventeen entries there, alongside BPC-157, TB-500, KPV, Semax, Selank acetate, Thymosin alpha-1, Epitalon, MOTS-C, Melanotan II, CJC-1295, AOD-9604 and GHK-Cu.\n\nFDA's stated reason, word for word: compounded drugs containing emideltide \"may pose risk for immunogenicity for certain routes of administration and may have complexities with regard to peptide-related impurities and API characterization. FDA has not identified safety-related information regarding emideltide for the proposed route... Therefore, the agency lacks sufficient information to know whether the drug would cause harm if administered to humans.\"\n\n[[embed:source:w_ww3yt0x9]]\n\nWhat that status means, precisely:\n\n- It is **not an approval** and it is **not a ban**. It is the record of a request. Somebody asked FDA to allow emideltide as a bulk substance for pharmacy compounding; FDA put it in category 2 — substances that may present significant safety risks; the person who asked then withdrew the request. FDA's own words on the page are that these substances were \"previously in category 2 of the interim policies\" and \"were withdrawn by the nominators.\"\n- The practical consequence is that emideltide is **not on the 503A or 503B bulks lists**. A compounding pharmacy cannot lawfully compound it as a bulk drug substance. What is offered for sale is research-use-only chemical, not medicine, and it comes with no assurance of identity, purity or sterility.\n- FDA's specific worries are, in order: clumping and whether the immune system would react to it by certain routes, peptide-related impurities, characterisation of the active ingredient, and — the operative one — an absence of safety information for the route being proposed.\n- No marketing authorisation for DSIP exists in any country, and none has ever been applied for.\n\n[[embed:source:s56]]\n\nA 2026 review of therapeutic peptides in orthopaedics lists DSIP among the recovery-oriented compounds and states the position for the whole class in one line: the preclinical work looks good, and there are no clinical trials.\n\n[[embed:source:w_d2edzzyj]]\n\n## Where that leaves the compound\n\nA confirmed nine-residue sequence.\n\nHalf gone from the blood in two to four minutes.\n\nNo gene, no precursor, no receptor, after fifty years of people looking for all three.\n\nA sleep record whose positive findings are concentrated in the laboratory that discovered it, and whose independent replications are null.\n\nA withdrawal literature covering several hundred patients with no control group in any of it, in a syndrome that ends on its own.\n\nOne seven-patient pain pilot, never followed up in forty-two years.\n\nA growth hormone claim that holds in rats and fails in the only eight humans it was ever tested in.\n\nZero registered trials, ever.\n\nThirty-five first-hand reports splitting eighteen good, ten bad, five nothing.\n\nAnd a regulatory file recording a withdrawn request and an agency saying it does not have enough information to know whether the substance would hurt you.\n\nThe peptide is named for the one effect its evidence supports least.\n\nThe sibling objects for this page, each one inspectable on its own terms:\n\n[[embed:bpc-157]]\n\n[[embed:kpv]]\n\n[[embed:ghk-cu]]\n\n[[embed:thymosin-alpha-1]]\n\n[[embed:ara-290]]\n","hero":"https://miscsubjects.com/img/gen/arcads-gpt-image-2b2483da-3951-4d1f-a958-fe10e99a05af.png","images":[],"style":{},"tags":["peptide","dsip"],"category":null,"model":"grok/grok-4.3","ledger":{"href":"/api/articles/dsip/ledger","live":true},"embeds":["bpc-157","kpv","ghk-cu","thymosin-alpha-1","ara-290"],"widgets":[],"home":true,"claims":[{"id":"c1","text":"In rats kept awake, the deep slow-wave sleep and the growth-hormone surge that normally follow both failed to appear once an antibody against DSIP was injected into a fluid space inside the brain.","section":"What DSIP did in rabbits, rats, cats and mice","tier":"preclinical","source_ids":["s1"],"source_status":"sourced","why_material":"Separates rat data from human evidence.","evidence_basis":"derived_inference","weight":0.22,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{},"who_claims":"system/unknown","posted_by":{"actor":"system/unknown","channel":"protocol/repair","ts":"2026-06-29T12:45:19.402Z","model":"grok/grok-4.3","rationale":"backfilled by ledger repair"},"slot":"what_is_known","source_role":"mechanism_support"},{"id":"c2","text":"In a 1992 double-blind trial, 16 people with long-running insomnia fell asleep faster and spent more of their time in bed actually asleep on DSIP than on placebo. They themselves noticed no difference.","section":"What the small human trials of DSIP actually found","tier":"human","source_ids":["s2"],"source_status":"sourced","why_material":"Primary human trial result, small sample noted.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{},"who_claims":"system/unknown","posted_by":{"actor":"system/unknown","channel":"protocol/repair","ts":"2026-06-29T12:45:19.402Z","model":"grok/grok-4.3","rationale":"backfilled by ledger repair"},"slot":"what_is_known","challenged_by":["c92"],"source_role":"mechanism_support"},{"id":"c3","text":"In a 1981 study of 6 people whose sleep was disturbed, DSIP lengthened sleep, cut the number of times they woke, and slightly raised REM, with no next-day dopiness.","section":"What the small human trials of DSIP actually found","tier":"mechanistic","source_ids":["s3"],"source_status":"sourced","why_material":"Additional small human trial separating from preclinical.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{},"who_claims":"system/unknown","posted_by":{"actor":"system/unknown","channel":"protocol/repair","ts":"2026-06-29T12:45:19.402Z","model":"grok/grok-4.3","rationale":"backfilled by ledger repair"},"slot":"what_is_known","source_role":"mechanism_support"},{"id":"c4","text":"A review reported that DSIP brought on sleep in rabbits, mice, rats, cats and human beings.","section":"What DSIP did in rabbits, rats, cats and mice","tier":"speculative","source_ids":["s4"],"source_status":"sourced","why_material":"Animal species-specific data.","evidence_basis":"derived_inference","weight":0.12,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{},"who_claims":"system/unknown","posted_by":{"actor":"system/unknown","channel":"protocol/repair","ts":"2026-06-29T12:45:19.402Z","model":"grok/grok-4.3","rationale":"backfilled by ledger repair"},"slot":"what_is_known","source_role":"mechanism_support"},{"id":"c5","text":"One person tracking their sleep said their deep sleep went, in their words, \"soooo high\" on DSIP, and that it did not leave them feeling tired.","section":"People who report that DSIP deepened their sleep","tier":"anecdotal","source_ids":["s5"],"source_status":"sourced","why_material":"Distinguishes user reports from trials.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{},"who_claims":"system/unknown","posted_by":{"actor":"system/unknown","channel":"protocol/repair","ts":"2026-06-29T12:45:19.402Z","model":"grok/grok-4.3","rationale":"backfilled by ledger repair"},"slot":"who_claims_what","source_role":"anecdotal_report"},{"id":"c6","text":"8 commercial and clinic pages selling or promoting DSIP are catalogued on this page. They are marketing copy, and none of them is evidence.","section":"Sellers and promotional posts pushing DSIP","tier":"speculative","weight":0.12,"status":"active","source_ids":["s16","s28","s29","s33","s50","s54","s56","s1"],"source_status":"sourced","who_claims":"commercial vendors","posted_by":{"actor":"system/protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:45:20.133Z","model":"system/audit-repair","rationale":""},"why_material":"Collapsed 14 duplicate marketing claims","slot":"who_claims_what","register":null},{"id":"c10","text":"This page is not medical advice. It is a catalogue of what has been claimed about DSIP, with the strength of the evidence marked on each claim, and decisions about your own health belong with a qualified professional.","section":"What this DSIP page is, and what it is not","tier":"human","weight":0.8,"status":"active","source_ids":[],"source_status":"unsourced","who_claims":"system/protocol","posted_by":{"actor":"system/protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:45:20.670Z","model":"system/audit-repair","rationale":""},"why_material":"Required constitution slot: disclaimer","slot":"disclaimer","register":null},{"id":"c11","text":"A 2006 review walked through where DSIP came from, starting with its isolation from rabbit blood, and set out which parts of the story were still unsettled.","tier":"human","weight":0.8,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"what_is_known","source_ids":["s6"],"source_status":"sourced","why_material":"Materialized from orphan source s6 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c12","text":"A 2024 paper described DSIP welded onto a carrier peptide so that more of it would cross from the blood into the brain, and tested whether the joined peptide still brought on sleep.","tier":"human","weight":0.8,"section":"What DSIP did in rabbits, rats, cats and mice","slot":"what_is_known","source_ids":["s7"],"source_status":"sourced","why_material":"Materialized from orphan source s7 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c13","text":"In a 2021 experiment, rats given a stroke got their movement back faster when DSIP was sprayed into the nose each day for 8 days.","tier":"preclinical","weight":0.5,"section":"The rat stroke experiment with DSIP sprayed into the nose","slot":"what_is_known","source_ids":["s8"],"source_status":"sourced","why_material":"Materialized from orphan source s8 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c14","text":"One person taking 500mcg described dreams three layers deep and a couple of lucid ones, and said they woke up rested.","tier":"anecdotal","weight":0.3,"section":"The vivid dreams people keep reporting on DSIP","slot":"who_claims_what","source_ids":["s9"],"source_status":"sourced","why_material":"Materialized from orphan source s9 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c15","text":"One person said their first night on DSIP added roughly 40 minutes each to their deep sleep and their REM.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s10"],"source_status":"sourced","why_material":"Materialized from orphan source s10 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c300","text":"That same person said the effect faded on them after 3-4 days of nightly use.","tier":"anecdotal","weight":0.3,"section":"Whether DSIP keeps working, or stops","slot":"who_claims_what","source_ids":["s10"],"source_status":"sourced","why_material":"Materialized from orphan source s10 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c16","text":"A 2025 video ran through DSIP for sleep, stress and pain, and stated plainly that it has no FDA approval.","tier":"anecdotal","weight":0.3,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"who_claims_what","source_ids":["s11"],"source_status":"sourced","why_material":"Materialized from orphan source s11 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c17","text":"A 2026 rundown pointed out that most of the DSIP sleep research is animal work, and that the handful of human trials all date from the 1980s.","tier":"speculative","weight":0.12,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"what_is_known","source_ids":["s12"],"source_status":"sourced","why_material":"Materialized from orphan source s12 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"adjacent_context"},{"id":"c18","text":"The same 2021 rat stroke study, catalogued again from a second copy of the write-up: the rats walked better on the rolling-rod test, while the damaged patch of brain did not shrink by a meaningful amount.","tier":"speculative","weight":0.12,"section":"The rat stroke experiment with DSIP sprayed into the nose","slot":"what_is_known","source_ids":["s13"],"source_status":"sourced","why_material":"Materialized from orphan source s13 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"adjacent_context"},{"id":"c19","text":"A 2026 video set out the leading guess about DSIP: that it leans on GABA receptors, the brain’s main calming switch.","tier":"anecdotal","weight":0.3,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s14"],"source_status":"sourced","why_material":"Materialized from orphan source s14 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c302","text":"That video also said the human studies on DSIP are inconclusive and that no regulator has approved it.","tier":"anecdotal","weight":0.3,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s14"],"source_status":"sourced","why_material":"Materialized from orphan source s14 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c301","text":"The same video described DSIP acting on the stress circuit that runs from the brain down to the adrenal glands, damping the ACTH and cortisol signal.","tier":"anecdotal","weight":0.3,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s14"],"source_status":"sourced","why_material":"Materialized from orphan source s14 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c20","text":"A 2026 thread in the Biohackers forum asked who had taken DSIP above 1.5 mg a night, and gathered what people said high doses did to them.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s15"],"source_status":"sourced","why_material":"Materialized from orphan source s15 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c22","text":"One person took DSIP for about 3 months and said it stopped working in the final month. 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that helps set deep sleep without the next-day hangover of sleeping pills. It is sales copy, not a study.","tier":"speculative","weight":0.12,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s37"],"source_status":"sourced","why_material":"Materialized from orphan source s37 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"adjacent_context"},{"id":"c43","text":"A 2025 post from a lifter said DSIP gives them heavy sleep every night and strong energy every morning, and that the better sleep showed up in their training.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s38"],"source_status":"sourced","why_material":"Materialized from orphan source s38 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c44","text":"A 2026 post described going from barely sleeping at all to 100mcg under the skin before bed, then waking 9 hours later having actually dreamt, vividly, and not groggy.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s39"],"source_status":"sourced","why_material":"Materialized from orphan source s39 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c45","text":"A 2026 Instagram reel describes DSIP as a naturally occurring peptide studied for deeper REM and slow-wave sleep, and notes that it has no FDA approval and can carry side effects.","tier":"anecdotal","weight":0.3,"section":"Sellers and promotional posts pushing DSIP","slot":"who_claims_what","source_ids":["s40"],"source_status":"sourced","why_material":"Materialized from orphan source s40 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c46","text":"The same report of nothing at all happening after two full vials under a doctor’s direction, ingested again from a second copy of the thread.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP did nothing at all","slot":"who_claims_what","source_ids":["s41"],"source_status":"sourced","why_material":"Materialized from orphan source s41 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c47","text":"A person with narcolepsy and fibromyalgia said their first 100mcg dose gave them the hardest sleep they had had in a long time. They were still tired the next day, but far less than usual.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s42"],"source_status":"sourced","why_material":"Materialized from orphan source s42 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c48","text":"On a first dose of 100 to 120mcg, one person’s tracker showed more restorative deep sleep in that single night than in the previous 3 days put together.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s43"],"source_status":"sourced","why_material":"Materialized from orphan source s43 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c49","text":"Another person went through a whole 5mg vial of DSIP and could not point to a single benefit from it.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP did nothing at all","slot":"who_claims_what","source_ids":["s44"],"source_status":"sourced","why_material":"Materialized from orphan source s44 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c50","text":"Someone who had woken at two or three in the morning every night for ten years of insomnia said DSIP is the only thing that keeps them asleep, and that it also brings down their wired feeling without wrecking their day.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s45"],"source_status":"sourced","why_material":"Materialized from orphan source s45 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c51","text":"A 2021 study found that a DSIP-like peptide called KND shrank the area of brain damage in mice when it was given as blood flow came back after a stroke.","tier":"preclinical","weight":0.22,"section":"What DSIP did in rabbits, rats, cats and mice","slot":"what_is_known","source_ids":["s46"],"source_status":"sourced","why_material":"Materialized from orphan source s46 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c52","text":"A 2023 video guide walks through the science behind DSIP and what it is claimed to do for deep sleep.","tier":"anecdotal","weight":0.3,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"who_claims_what","source_ids":["s47"],"source_status":"sourced","why_material":"Materialized from orphan source s47 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c53","text":"Someone two days without real sleep posted in a peptide forum asking about DSIP. No outcome was ever reported in the thread.","tier":"anecdotal","weight":0.3,"section":"DSIP threads where somebody asked first and never reported back","slot":"who_claims_what","source_ids":["s48"],"source_status":"sourced","why_material":"Materialized from orphan source s48 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c54","text":"A person already taking a benzodiazepine for sleep asked whether the DSIP their doctor was offering was worth buying, and got back a mix of personal experience and advice about buying it on the grey market instead.","tier":"anecdotal","weight":0.3,"section":"Where people say their DSIP came from","slot":"who_claims_what","source_ids":["s49"],"source_status":"sourced","why_material":"Materialized from orphan source s49 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c56","text":"A 2024 study put the DSIP fusion peptide into mice whose sleep had been wrecked with a drug, and measured both their sleep and the balance of their brain-signalling chemicals.","tier":"preclinical","weight":0.22,"section":"What DSIP did in rabbits, rats, cats and mice","slot":"what_is_known","source_ids":["s51"],"source_status":"sourced","why_material":"Materialized from orphan source s51 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c57","text":"A discussion thread argued that when DSIP is doing what it is meant to do, the body sits further into rest-and-digest mode, and that this is a bigger thing than sleep alone.","tier":"anecdotal","weight":0.3,"section":"What people report from DSIP other than sleep","slot":"who_claims_what","source_ids":["s52"],"source_status":"sourced","why_material":"Materialized from orphan source s52 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c58","text":"A 1986 review pulled together everything published on DSIP since the work that isolated it, which ran from 1963 to 1977.","tier":"human","weight":0.8,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s53"],"source_status":"sourced","why_material":"Materialized from orphan source s53 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c305","text":"That same 1986 review listed the effects claimed for DSIP beyond sleep, in insomnia, pain and withdrawal, and floated adrenaline signalling as a possible route.","tier":"human","weight":0.8,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s53"],"source_status":"sourced","why_material":"Materialized from orphan source s53 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"mechanism_support"},{"id":"c60","text":"A 2026 review says the DSIP evidence rests on small trials that disagree with each other, and that larger, properly designed trials would be needed to settle whether it does anything for sleep disorders.","tier":"speculative","weight":0.12,"section":"The proposed explanations for how DSIP works on sleep","slot":"mechanism","source_ids":["s55"],"source_status":"sourced","why_material":"Materialized from orphan source s55 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"adjacent_context"},{"id":"c306","text":"No gene and no receptor for DSIP have ever been identified. That is why it is still called investigational and why it carries no FDA approval.","tier":"speculative","weight":0.12,"section":"What nobody has pinned down about DSIP","slot":"mechanism","source_ids":["s55"],"source_status":"sourced","why_material":"Materialized from orphan source s55 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"adjacent_context"},{"id":"c62","text":"One person’s tracker showed the longest stretch of uninterrupted sleep it had ever recorded on their first DSIP night, with no wake-ups at all.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s57"],"source_status":"sourced","why_material":"Materialized from orphan source s57 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c307","text":"The same person then could not get to sleep on the nights that followed, lying awake well over two hours despite being exhausted.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s57"],"source_status":"sourced","why_material":"Materialized from orphan source s57 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c63","text":"After a few days on DSIP, one person got sleepy within 15 to 20 minutes of their dose, went straight back down after any wake-up, and said they had never felt more rested in the morning.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s58"],"source_status":"sourced","why_material":"Materialized from orphan source s58 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c64","text":"Someone whose sleep was already good used DSIP for 2 months and noticed nothing much either way.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP did nothing at all","slot":"who_claims_what","source_ids":["s59"],"source_status":"sourced","why_material":"Materialized from orphan source s59 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c65","text":"One person coming off growth-hormone peptides said DSIP helped them fall asleep and stay asleep with better deep sleep, though it also stretched their nights longer than they wanted.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s60"],"source_status":"sourced","why_material":"Materialized from orphan source s60 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c66","text":"One person tested DSIP by dose. Two nights at 1mg gave four hours of sleep each. The third night at 1.5mg gave 9 hours, though they had gone into it badly short of sleep.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s61"],"source_status":"sourced","why_material":"Materialized from orphan source s61 by ledger repair","status":"active","who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/repair","ts":"2026-06-29T12:50:35.212Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c68","text":"The DSIP reports gathered on this page do not agree with one another. Some people describe much better sleep, some describe no change at all, and some describe sleep that got worse.","tier":"anecdotal","weight":0.3,"section":"Taken together, the DSIP reports contradict each other","slot":"who_claims_what","source_ids":["s5","s9","s10"],"source_status":"sourced","why_material":"This claim captures the diversity in anecdotal evidence, which is important for a comprehensive understanding of DSIP's effects as reported by users.","status":"active","who_claims":"kimi/moonshot-v1-8k","posted_by":{"actor":"kimi/moonshot-v1-8k","channel":"protocol/collaborate","ts":"2026-06-29T13:44:44.428Z","model":"kimi/moonshot-v1-8k","rationale":""},"source_role":"anecdotal_report"},{"id":"c70","text":"One person taking DSIP for recovery said they wake up less sore, sleep well, and get wild dreams with it.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their 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working.","tier":"anecdotal","weight":0.3,"section":"Whether DSIP keeps working, or stops","slot":"who_claims_what","source_ids":["s65"],"source_status":"sourced","why_material":"Materialized from orphan source s65 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:36:45.530Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c74","text":"One person said DSIP worked on their sleep but left them feeling hung over the next day.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s66"],"source_status":"sourced","why_material":"Materialized from orphan source s66 by ledger 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whose sleep runs from five in the morning to one in the afternoon asked whether DSIP could reset their body clock. Nobody in the thread reported an outcome.","tier":"anecdotal","weight":0.3,"section":"DSIP threads where somebody asked first and never reported back","slot":"who_claims_what","source_ids":["s70"],"source_status":"sourced","why_material":"Materialized from orphan source s70 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:36:45.530Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c79","text":"A veteran whose sleep had been broken for fourteen years since coming home from the Iraq war said that on DSIP they now get sleepy naturally at nine or ten at night and wake up rested at five or six.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s71"],"source_status":"sourced","why_material":"Materialized from orphan source s71 by ledger 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variability.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s72"],"source_status":"sourced","why_material":"Materialized from orphan source s72 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:36:45.530Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c81","text":"One person said DSIP was horrible for them, about four hours of sleep, with the single upside that they were not tired the following day.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s73"],"source_status":"sourced","why_material":"Materialized from orphan source s73 by ledger 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remember afterwards and a clearer head.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s74"],"source_status":"sourced","why_material":"Materialized from orphan source s74 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:36:45.530Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c83","text":"One person described DSIP as quiet rather than sedating: fewer wake-ups, deeper sleep and heavier dreams by the second and third week, and mornings that were clear rather than foggy.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s75"],"source_status":"sourced","why_material":"Materialized from orphan source s75 by ledger 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Some people got there after changing the dose or the timing, and others got nothing and quit early.","tier":"anecdotal","weight":0.3,"section":"Whether DSIP keeps working, or stops","slot":"who_claims_what","source_ids":["s78"],"source_status":"sourced","why_material":"Materialized from orphan source s78 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:38:24.249Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c311","text":"That same person reported no fading of the effect after months of use, and said they settled at 300 to 500mcg.","tier":"anecdotal","weight":0.3,"section":"Whether DSIP keeps working, or stops","slot":"who_claims_what","source_ids":["s78"],"source_status":"sourced","why_material":"Materialized from orphan source s78 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:38:24.249Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c87","text":"One post called DSIP the deep-sleep one, the peptide that gives restorative rest without grogginess, and rated it for anyone whose recovery is poor.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s79"],"source_status":"sourced","why_material":"Materialized from orphan source s79 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:38:24.249Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c88","text":"A promotional post sells DSIP on deeper REM cycles and better recovery. It carries no data at all.","tier":"anecdotal","weight":0.3,"section":"Sellers and promotional posts pushing DSIP","slot":"who_claims_what","source_ids":["s80"],"source_status":"sourced","why_material":"Materialized from orphan source s80 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T15:38:24.249Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c89","text":"That same 2006 review is the reason this page cannot tell you how DSIP works. After decades of study, both its mechanism and its real uses were still open questions.","tier":"human","weight":0.8,"section":"What nobody has pinned down about DSIP","slot":"what_is_unknown","source_ids":["s6"],"source_status":"sourced","why_material":"Highlights a significant gap in the scientific understanding of DSIP's fundamental nature and efficacy, directly from a review title.","status":"active","who_claims":"gemini-collaborator","posted_by":{"actor":"gemini/gemini-2.5-flash","channel":"protocol/collaborate","ts":"2026-06-29T16:32:28.303Z","model":"gemini/gemini-2.5-flash","rationale":""},"source_role":"mechanism_support"},{"id":"c90","text":"The same lucid-dream report from that DSIP write-up, catalogued a third time from another copy of the thread.","tier":"anecdotal","weight":0.3,"section":"The vivid dreams people keep reporting on DSIP","slot":"who_claims_what","source_ids":["s9"],"source_status":"sourced","why_material":"Adds specific anecdotal experience from an unused source, enriching the 'who_claims_what' section with user-reported effects.","status":"active","who_claims":"gemini-collaborator","posted_by":{"actor":"gemini/gemini-2.5-flash","channel":"protocol/collaborate","ts":"2026-06-29T16:32:28.303Z","model":"gemini/gemini-2.5-flash","rationale":""},"source_role":"anecdotal_report"},{"id":"c91","text":"Whether enough DSIP gets from the blood into the brain to account for what people report is still an open question. It is the reason researchers built the fused version in the first place.","tier":"human","weight":0.8,"section":"What nobody has pinned down about DSIP","slot":"what_is_unknown","source_ids":["s7"],"source_status":"sourced","why_material":"Introduces a fundamental mechanistic question regarding how DSIP might exert its effects in the brain, highlighting an area of ongoing research or complexity.","status":"active","who_claims":"gemini-collaborator","posted_by":{"actor":"gemini/gemini-2.5-flash","channel":"protocol/collaborate","ts":"2026-06-29T16:32:28.303Z","model":"gemini/gemini-2.5-flash","rationale":""},"source_role":"mechanism_support"},{"id":"c93","text":"One person stacking 200mcg of DSIP with 500mcg of Selank before bed said they fell asleep faster, woke fewer times, and recovered better from training. That is one person’s experience, not advice.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s81"],"source_status":"sourced","why_material":"Materialized from orphan source s81 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c94","text":"The dose in that stack, from the same person’s reply: 200mcg of DSIP and 500mcg of Selank, taken 1 to 1.5h before bed.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s82"],"source_status":"sourced","why_material":"Materialized from orphan source s82 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c95","text":"A community post argued that the bigger DSIP story is the stress axis rather than sleep.","tier":"anecdotal","weight":0.3,"section":"What people report from DSIP other than sleep","slot":"who_claims_what","source_ids":["s83"],"source_status":"sourced","why_material":"Materialized from orphan source s83 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c313","text":"The protocol described in that post was 100 to 200mcg a night, taken 30 to 60 minutes before bed, with effects inside one to two weeks and 4 to 8 weeks for the stress system to resettle.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s83"],"source_status":"sourced","why_material":"Materialized from orphan source s83 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c96","text":"A post linked a podcast episode on DSIP, told as a cautionary story: hailed as a miracle for insomnia, then held up to scrutiny.","tier":"anecdotal","weight":0.3,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"who_claims_what","source_ids":["s84"],"source_status":"sourced","why_material":"Materialized from orphan source s84 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c97","text":"A post claimed DSIP is useful to people coming off alcohol, benzodiazepines, opiates and kratom. It is one person’s claim with nothing behind it.","tier":"anecdotal","weight":0.3,"section":"What people report from DSIP other than sleep","slot":"who_claims_what","source_ids":["s85"],"source_status":"sourced","why_material":"Materialized from orphan source s85 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c98","text":"A seller’s guide describes DSIP as a naturally occurring nine-amino-acid peptide found in the brain and other tissues, and labels its own product research-grade and not for human consumption.","tier":"anecdotal","weight":0.3,"section":"Sellers and promotional posts pushing DSIP","slot":"who_claims_what","source_ids":["s86"],"source_status":"sourced","why_material":"Materialized from orphan source s86 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c99","text":"Someone asked whether DSIP interferes with prescription stimulants for ADHD. The only reply said they had no experience of it, so the question sits here unanswered.","tier":"anecdotal","weight":0.3,"section":"Whether DSIP interferes with prescription stimulants is unanswered here","slot":"limitations","source_ids":["s87"],"source_status":"sourced","why_material":"Materialized from orphan source s87 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c100","text":"A doctor’s post reported that the FDA discussion graded the DSIP evidence D+ for sleep, for withdrawal and for pain. Poor, but not nothing.","tier":"anecdotal","weight":0.3,"section":"Where DSIP stands with the FDA under the name Emideltide","slot":"who_claims_what","source_ids":["s88"],"source_status":"sourced","why_material":"Materialized from orphan source s88 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c101","text":"One person said 10mg of DSIP alongside a tesamorelin and ipamorelin blend put them straight to sleep.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s89"],"source_status":"sourced","why_material":"Materialized from orphan source s89 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c102","text":"A post spelled out what the July 24 review actually means: DSIP, listed as Emideltide, is one of seven peptides being looked at for a return to routine compounding, not being approved as a drug.","tier":"anecdotal","weight":0.3,"section":"Where DSIP stands with the FDA under the name Emideltide","slot":"who_claims_what","source_ids":["s90"],"source_status":"sourced","why_material":"Materialized from orphan source s90 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:36:43.609Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c103","text":"Another post recommended that same DSIP plus tesamorelin and ipamorelin stack for sleep, with nothing behind it but the poster’s own use.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s91"],"source_status":"sourced","why_material":"Materialized from orphan source s91 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c104","text":"One person said they threw out their DSIP over doubts about where it had come from, and now buys only from a list they trust.","tier":"anecdotal","weight":0.3,"section":"Where people say their DSIP came from","slot":"who_claims_what","source_ids":["s92"],"source_status":"sourced","why_material":"Materialized from orphan source s92 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c105","text":"One person said DSIP gave them the worst insomnia of anything they had tried, across different brands and different doses over several years.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s93"],"source_status":"sourced","why_material":"Materialized from orphan source s93 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c314","text":"Others in that thread said DSIP worsened their sleep too, and one said it changed their REM without changing anything else.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s93"],"source_status":"sourced","why_material":"Materialized from orphan source s93 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c106","text":"A second person in that same thread said DSIP made their sleep worse across 3 separate attempts.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s94"],"source_status":"sourced","why_material":"Materialized from orphan source s94 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c107","text":"A third person in that thread said their DSIP shots made sleep a lot worse.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP made their sleep worse","slot":"who_claims_what","source_ids":["s95"],"source_status":"sourced","why_material":"Materialized from orphan source s95 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c108","text":"One person said DSIP changes neither how long they sleep nor how much deep sleep they get, but that they now always get REM however short the night is, which was not true before they started it.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s96"],"source_status":"sourced","why_material":"Materialized from orphan source s96 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c109","text":"One person reported that DSIP at 1mg under the skin, or 50mcg into each nostril, gave complete relief from opiate withdrawal, with the injected form lasting longer and the nasal form coming on faster.","tier":"anecdotal","weight":0.3,"section":"What people report from DSIP other than sleep","slot":"who_claims_what","source_ids":["s97"],"source_status":"sourced","why_material":"Materialized from orphan source s97 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:38:25.614Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c110","text":"One person running 250 mcg of DSIP Monday to Friday with weekends off said the first night gave over six hours of smooth, unbroken sleep, and that 250 mcg was the dose that worked best for them.","tier":"anecdotal","weight":0.3,"section":"The DSIP doses, timing and stacks people report using","slot":"who_claims_what","source_ids":["s98"],"source_status":"sourced","why_material":"Materialized from orphan source s98 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:40:38.210Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c111","text":"A community guide lists what DSIP is studied for: deep and slow-wave sleep, overnight recovery, and models of stress and overtraining.","tier":"anecdotal","weight":0.3,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"who_claims_what","source_ids":["s99"],"source_status":"sourced","why_material":"Materialized from orphan source s99 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:40:38.210Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c112","text":"One person tried DSIP at 125mcg in the daytime and about 300mcg before sleep and felt nothing at all from either.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP did nothing at all","slot":"who_claims_what","source_ids":["s100"],"source_status":"sourced","why_material":"Materialized from orphan source s100 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:40:38.210Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c113","text":"One person said they sleep through the night far better after a few doses of DSIP, and that they cycle it every other night.","tier":"anecdotal","weight":0.3,"section":"People who report that DSIP deepened their sleep","slot":"who_claims_what","source_ids":["s101"],"source_status":"sourced","why_material":"Materialized from orphan source s101 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:40:38.210Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c114","text":"A peptide round-up lists DSIP under sleep, next to Epitalon, with no detail attached to it.","tier":"anecdotal","weight":0.3,"section":"Reviews and write-ups that retell the DSIP story without new data","slot":"who_claims_what","source_ids":["s102"],"source_status":"sourced","why_material":"Materialized from orphan source s102 by ledger repair","status":"active","who_claims":"grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:40:38.210Z","model":"grok/grok-4.3","rationale":""},"source_role":"anecdotal_report"},{"id":"c115","text":"This page is the DSIP entry in a public ledger of claims. Every claim carries its evidence strength and its sources, and the whole record is what has been said about DSIP in the literature and online, not what anyone should do about it.","section":"What this DSIP page is, and what it is not","tier":"runtime","weight":0.35,"status":"active","source_ids":[],"source_status":"unsourced","who_claims":"miscsubjects protocol","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T20:41:05.566Z","model":"fill-slots","rationale":""},"why_material":"Required constitution slot: what_it_is","slot":"what_it_is","register":null}],"sources":[{"id":"s1","type":"pubmed","url":"https://www.pnas.org/doi/10.1073/pnas.85.10.3653","title":"Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat","quote":"These increases were blocked by microinjection into the third cerebral ventricle of highly specific antiserum to DSIP.","summary":"Rat sleep deprivation study showing DSIP antiserum effect on SWS and GH.","claim_ids":["c1","c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:33:20.929Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"13fbfcb0a20d798fda382c3b46248b5c6664ff7ebef2f9a7775f81e9eb3c0192","source_role":"mechanism_support"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/1299794/","title":"Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study","quote":"The results for objective sleep quality indicated higher sleep efficiency and shorter sleep latency with DSIP as compared to placebo.","summary":"1992 human trial abstract on insomniacs.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:33:20.929Z","link_status":"ok","quote_status":"verified","prev":"13fbfcb0a20d798fda382c3b46248b5c6664ff7ebef2f9a7775f81e9eb3c0192","hash":"aae095fb0ef2e9797e22740c3a018a47edecdd49ab8beb7fc7114e0969e34c51","source_role":"mechanism_support"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/7028502/","title":"The influence of synthetic DSIP on disturbed human sleep","quote":"longer sleep duration and a higher quality of sleep with fewer interruptions; slightly more REM-sleep, but no day-time sedation","summary":"1981 human study on insomniacs.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:33:20.929Z","link_status":"ok","quote_status":"verified","prev":"aae095fb0ef2e9797e22740c3a018a47edecdd49ab8beb7fc7114e0969e34c51","hash":"bfbe7cb30a4b5a1fd87452da7db84121b98f73cf74cfbe859fc27f0e86d46349","source_role":"mechanism_support"},{"id":"s4","type":"review","url":"https://journals.lww.com/ejanaesthesiology/fulltext/2001/07000/delta_sleep_inducing_peptide.1.aspx","title":"Delta sleep-inducing peptide","quote":"DSIP promotes sleep and this has been demonstrated in rabbits, mice, rats, cats and human beings","summary":"Review summarizing species sleep promotion data.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:33:20.929Z","link_status":"ok","quote_status":"verified","prev":"bfbe7cb30a4b5a1fd87452da7db84121b98f73cf74cfbe859fc27f0e86d46349","hash":"997559e29f4848995b9d40d33b2c03d0bda503e16c94c35cc453b67f972a42c2","source_role":"mechanism_support"},{"id":"s5","type":"instagram","url":"https://www.instagram.com/reel/DURfvtYj6Qz/","title":"DSIP Peptide user discussion","quote":"my deep sleep is soooo high. It doesn't make you tired or ...","summary":"User anecdote on tracked deep sleep.","claim_ids":["c5","c68"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:33:20.929Z","link_status":"ok","quote_status":"unverified","prev":"997559e29f4848995b9d40d33b2c03d0bda503e16c94c35cc453b67f972a42c2","hash":"a019216c7e81f84822e0775ca58712a8b1b5611329155fabd9e9aa99c4e05689","source_role":"anecdotal_report"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16539679/","title":"Delta sleep-inducing peptide (DSIP): a still unresolved riddle","quote":"Delta sleep-inducing peptide (DSIP) was isolated from rabbit cerebral venous blood by Schoenenberger-Monnier group from Basel in 1977 and initially regarded as a candidate sleep-promoting factor.","summary":"2006 review discussing the history and unresolved aspects of DSIP as a sleep factor.","author":"","publisher":"","date":"","claim_ids":["c11","c89"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"ok","quote_status":"verified","prev":"a019216c7e81f84822e0775ca58712a8b1b5611329155fabd9e9aa99c4e05689","hash":"3a5c5e35362ee5ccdc8fe89a3062ee9042c0a978649b6dfafe664b9f4c146733","source_role":"mechanism_support"},{"id":"s7","type":"review","url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1439536/full","title":"Pichia pastoris secreted peptides crossing the blood-brain barrier","quote":"Delta sleep-inducing peptide (DSIP) is composed of 9 amino acids and has been implicated in the regulation of sleep, modulation of stress (Morgan, 2023), and exhibits a wide range of physiological and pharmacological effects.","summary":"2024 paper on engineered DSIP fusion peptides for better BBB crossing and sleep effects.","author":"","publisher":"","date":"","claim_ids":["c12","c91"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"ok","quote_status":"unverified","prev":"3a5c5e35362ee5ccdc8fe89a3062ee9042c0a978649b6dfafe664b9f4c146733","hash":"bd66518bb024dd70c7eb9b3756fef0c849e4468be32350e82ea5b11a03b690dd","source_role":"mechanism_support"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/34500605/","title":"Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke","quote":"Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.","summary":"2021 animal study showing DSIP aids motor recovery post-stroke in rats.","author":"","publisher":"","date":"","claim_ids":["c13"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"ok","quote_status":"verified","prev":"bd66518bb024dd70c7eb9b3756fef0c849e4468be32350e82ea5b11a03b690dd","hash":"945bbc0bb0cfa091268c9c016d7f2089892b81a69b344f654ce9fd2ef49a5d93","source_role":"mechanism_support"},{"id":"s9","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1pcdd5q/dsip_review_the_sleep_peptide_that_gave_me/","title":"DSIP Review: The Sleep Peptide That Gave Me Inception Level Lucid Dreams","quote":"it’s like Inception in a bottle. You have dreams that are three layers deep lol. They’re the most vivid dreams possible.","summary":"User anecdote on vivid lucid dreams and improved sleep from DSIP at 500mcg.","author":"","publisher":"","date":"","claim_ids":["c14","c68","c90"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"ok","quote_status":"unverified","prev":"945bbc0bb0cfa091268c9c016d7f2089892b81a69b344f654ce9fd2ef49a5d93","hash":"929d502ccb1d9960865068bd5ef04e03e5a3ef42d2bc717fd4d125c3dd810249","source_role":"anecdotal_report"},{"id":"s10","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1qab419/dsip_greatly_improved_sleep_deep_and_rem/","title":"DSIP GREATLY Improved Sleep (DEEP and REM)!!","quote":"I tried Delta Sleep-Inducing Peptide (DSIP) last night and it improved by Deep and REM sleep by about 40mins each!!","summary":"Reddit user reports increased deep and REM sleep with DSIP, notes tolerance after 3-4 days.","author":"","publisher":"","date":"","claim_ids":["c15","c68"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"ok","quote_status":"unverified","prev":"929d502ccb1d9960865068bd5ef04e03e5a3ef42d2bc717fd4d125c3dd810249","hash":"e9ef91a1f09f8fcfd1e2e8cf0ab97643d9e27ee4496f67b2becf99b5cffbf229","source_role":"anecdotal_report"},{"id":"s11","type":"youtube","url":"https://www.youtube.com/watch?v=grwWLZedRQQ","title":"DSIP Peptide: Revolutionizing Sleep, Stress, and Pain Management","quote":"Discover the groundbreaking potential of Delta Sleep Inducing Peptide (DSIP) in enhancing sleep quality, reducing stress, managing pain, and supporting recovery.","summary":"2025 YouTube video overview of DSIP for sleep, stress, and pain, noting it's not FDA approved but used in practice.","author":"","publisher":"","date":"","claim_ids":["c16"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"http_429","quote_status":"unverified","prev":"e9ef91a1f09f8fcfd1e2e8cf0ab97643d9e27ee4496f67b2becf99b5cffbf229","hash":"344983146044b72cae48e5ef58231ec33cf65687ae813aea9d009d9d785e7ff3","source_role":"anecdotal_report"},{"id":"s12","type":"medical","url":"https://www.innerbody.com/dsip-delta-sleep-inducing-peptide","title":"DSIP (Delta Sleep-Inducing Peptide) | Full Rundown [2026]","quote":"A large share of DSIP studies on sleep health have been animal studies, but a few human trials took place in the 1980s.","summary":"2026 review summarizing limited human trials from 1980s and safety profile.","author":"","publisher":"","date":"","claim_ids":["c17"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:05.504Z","link_status":"ok","quote_status":"verified","prev":"344983146044b72cae48e5ef58231ec33cf65687ae813aea9d009d9d785e7ff3","hash":"382583fe79ee2a1dd5cd94e0f8d5a14a4f2934b0864e56082b23c1146d4ba580","source_role":"adjacent_context"},{"id":"s13","type":"medical","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8434407/","title":"Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke","quote":"Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.","summary":"2021 rat study showing DSIP intranasal treatment after focal stroke improved motor recovery on rotarod test despite non-significant infarct reduction.","author":"","publisher":"","date":"","claim_ids":["c18"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:33.452Z","link_status":"ok","quote_status":"verified","prev":"382583fe79ee2a1dd5cd94e0f8d5a14a4f2934b0864e56082b23c1146d4ba580","hash":"50ebfe8f986dfef80a811fbb3c5ff3cec1004448111ea57010a0c7bbbd576d15","source_role":"adjacent_context"},{"id":"s14","type":"youtube","url":"https://www.youtube.com/watch?v=dz6vYHXE3Yc","title":"How does the Peptide DSIP Work?","quote":"DSIP is a neuropeptide studied for its potential involvement in sleep regulation, stress responses, and neuroendocrine signaling. Although its exact mechanism of action remains unclear, research suggests it may influence multiple brain pathways related to rest and recovery.","summary":"2026 video explaining proposed DSIP mechanisms via GABA receptors and HPA axis regulation of ACTH/cortisol; notes inconclusive human studies and lack of FDA approval.","author":"","publisher":"","date":"","claim_ids":["c19"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:33.452Z","link_status":"http_429","quote_status":"unverified","prev":"50ebfe8f986dfef80a811fbb3c5ff3cec1004448111ea57010a0c7bbbd576d15","hash":"1ab1cadce89f3138db2fdd4f381afa0448fa67cf3686ea5bf35234bafa2a8651","source_role":"anecdotal_report"},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1stygfi/dsip_is_wild/","title":"DSIP is Wild","quote":"Anyone try high dose DSIP ? 1.5+ mg ( Delta-Sleep-Inducing Peptide )","summary":"2026 Reddit thread in r/Biohackers discussing personal experiences with high-dose DSIP for sleep and vivid effects.","author":"","publisher":"","date":"","claim_ids":["c20"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:33.452Z","link_status":"ok","quote_status":"unverified","prev":"1ab1cadce89f3138db2fdd4f381afa0448fa67cf3686ea5bf35234bafa2a8651","hash":"c05940ecad0c51baf1c1bea7c9d2e09d93a443ca37e4a43548276fe091728a4a","source_role":"anecdotal_report"},{"id":"s16","type":"business","url":"https://newtropin.com/blog/dsip-emideltide-fda-update","title":"DSIP (Emideltide) FDA Update: Sleep Peptide Moves Forward","quote":"The FDA’s updated 503A document, published April 15, 2026, removes Emideltide/DSIP (both Emideltide acetate and Emideltide free base) from Category 2 and schedules the peptide for PCAC review on July 24, 2026.","summary":"2026 update on DSIP (Emideltide) regulatory status changes by FDA regarding compounding.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:33.452Z","link_status":"ok","quote_status":"verified","prev":"c05940ecad0c51baf1c1bea7c9d2e09d93a443ca37e4a43548276fe091728a4a","hash":"23d7673cbcb5fc6d801f99daab7fdf1ee0e452ddb48477cee4349bc6ac606186","source_role":"adjacent_context"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1afsuih/any_personal_experience_with_dsip_delta/","title":"any personal experience with DSIP (Delta Sleep-Inducing ...","quote":"Happy to - soooo, unfortunately, dsip lost its effect (I took it for about 3 months and the last month it wasn't working). Tried from two different sources and still nada.","summary":"User reports initial use then loss of effect after ~3 months; tolerance noted, switched to other aids.","author":"","publisher":"","date":"","claim_ids":["c22"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:58.441Z","link_status":"ok","quote_status":"unverified","prev":"23d7673cbcb5fc6d801f99daab7fdf1ee0e452ddb48477cee4349bc6ac606186","hash":"6f473c999271dd2ca2217f414367c33b78ba8f1680228594540a4b2c9a6f8d8b","source_role":"anecdotal_report"},{"id":"s18","type":"reddit","url":"https://www.reddit.com/r/LucidDreaming/comments/1tkp3dv/dsip_review_the_sleep_peptide_that_gave_me/","title":"DSIP Review: The Sleep Peptide That Gave Me Inception ...","quote":"If I had to describe my experience so far in one sentence, it’s this: it’s like Inception in a bottle. You have dreams that are three layers deep lol. They’re the most vivid dreams possible. I’ve had a couple lucid dreams, and when you wake up, you’re like, holy shit… was that real or was that a dream? I cannot express enough how crazy my dreams have been. I’ve definitely noticed I feel a lot more well-rested when I wake up.","summary":"Positive report of extremely vivid layered dreams, lucid dreams, and feeling well-rested on DSIP at 500mcg.","author":"","publisher":"","date":"","claim_ids":["c23"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:58.441Z","link_status":"ok","quote_status":"unverified","prev":"6f473c999271dd2ca2217f414367c33b78ba8f1680228594540a4b2c9a6f8d8b","hash":"8da2c91b849be5e18880db1b8c31c59b783168dd68f2188481f226f3845e9645","source_role":"anecdotal_report"},{"id":"s19","type":"anecdotal","url":"https://forum.age-reversal.net/t/y4yz380/sleep-quality-dsip","title":"Sleep Quality DSIP - Self-Experimentation - Age Reversal Forum","quote":"For the past couple years I have been using a peptide called deep-sleep-inducing-peptide (DSIP). Its a sub-q injection, and for me it has been remarkably effective. Since using DSIP, I sleep through the night, only waking briefly for bathroom breaks before quickly falling back asleep. I've also noticed I'm dreaming nightly. ... If you're experiencing similar sleep disruptions, you might consider DSIP as a potential solution. It's been a game-changer for my sleep quality","summary":"Long-term user (2+ years) reports dramatically improved sleep continuity, quick return to sleep after waking, and nightly dreaming; calls it a game-changer.","author":"","publisher":"","date":"","claim_ids":["c24"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:58.441Z","link_status":"ok","quote_status":"unverified","prev":"8da2c91b849be5e18880db1b8c31c59b783168dd68f2188481f226f3845e9645","hash":"1783cdda619eb0357da2b7187e6918855b869cd8f778472deb9bac3361996f54","source_role":"anecdotal_report"},{"id":"s20","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1tfq46s/dsip_is_disappointing/","title":"r/Peptides - DSIP is disappointing","quote":"I was disappointed that DSIP had no effect for me. I tried it two times for the full vial with dosing under the direction of a licensed medical ...","summary":"User reports no effect from DSIP despite following medical dosing instructions; disappointing outcome.","author":"","publisher":"","date":"","claim_ids":["c25"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:51:58.441Z","link_status":"ok","quote_status":"unverified","prev":"1783cdda619eb0357da2b7187e6918855b869cd8f778472deb9bac3361996f54","hash":"826873bdcdfcff3ebb541a0822d1241c9ab5bcef63a3daa897da3b0cc9900e9f","source_role":"anecdotal_report"},{"id":"s21","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/6548970/","title":"Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes.","quote":"DSIP lowered significantly the pain levels of 6 out of 7 patients after intravenous administration on 5 consecutive days followed by 5 injections every 48-72 h.","summary":"1984 study on DSIP for chronic pain, showing significant pain reduction in most patients.","author":"","publisher":"","date":"","claim_ids":["c26"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"ok","quote_status":"verified","prev":"826873bdcdfcff3ebb541a0822d1241c9ab5bcef63a3daa897da3b0cc9900e9f","hash":"191b8374ce4518189a3dc66d87d1373398c4859af95578e47529a3ef53eb430f","source_role":"mechanism_support"},{"id":"s22","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/3622582/","title":"Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia","quote":"The treatment substantially improved night sleep with the first and additionally with repeated doses. Alertness and performance at daytime increased significantly.","summary":"1987 human study on DSIP for chronic insomnia showing improved sleep and daytime function.","author":"","publisher":"","date":"","claim_ids":["c27"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"ok","quote_status":"unverified","prev":"191b8374ce4518189a3dc66d87d1373398c4859af95578e47529a3ef53eb430f","hash":"254cd9ab4c200befe4f9d0f60ae4d9d9e61328f20cd4ad063c9991a95a318101","source_role":"mechanism_support"},{"id":"s23","type":"medical","url":"https://drlewis.com/dsip-delta-sleep-inducing-peptide/","title":"DSIP Peptide: Research, Benefits, Dosage & Sleep Studies","quote":"DSIP ( Delta Sleep-Inducing Peptide ) is a neuropeptide studied for sleep, stress, and brain health.","summary":"2026 article reviewing DSIP research, benefits, dosing for sleep and stress.","author":"","publisher":"","date":"","claim_ids":["c28"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"ok","quote_status":"unverified","prev":"254cd9ab4c200befe4f9d0f60ae4d9d9e61328f20cd4ad063c9991a95a318101","hash":"e2005cde5fb6ff7edb29904e6beafce37d5a3cb7bc75ac118b55d905edbe5acf","source_role":"adjacent_context"},{"id":"s24","type":"medical","url":"https://riteaid.com/peptides/dsip","title":"DSIP Peptide: Benefits, Dosage & 2026 Legal Status","quote":"DSIP — Delta Sleep-Inducing Peptide — is a naturally occurring neuropeptide studied for its role in sleep regulation and stress resilience.","summary":"2026 medical overview of DSIP including benefits, dosage, and FDA/compounding status.","author":"","publisher":"","date":"","claim_ids":["c29"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"http_403","quote_status":"unverified","prev":"e2005cde5fb6ff7edb29904e6beafce37d5a3cb7bc75ac118b55d905edbe5acf","hash":"a216dcfee4e8b479d5d90de92de4ba624e208f1a5070124c9d6825cab448b712","source_role":"adjacent_context"},{"id":"s25","type":"medical","url":"https://www.mdpi.com/1420-3049/26/17/5173","title":"Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke","quote":"Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.","summary":"2021 animal study showing DSIP aids motor recovery post-stroke via intranasal admin.","author":"","publisher":"","date":"","claim_ids":["c30"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"http_403","quote_status":"unverified","prev":"a216dcfee4e8b479d5d90de92de4ba624e208f1a5070124c9d6825cab448b712","hash":"686644a0d57513dad79faca19013018ded55873e390b7853f54533cf2c1880c6","source_role":"adjacent_context"},{"id":"s26","type":"reddit","url":"https://www.reddit.com/r/sleephackers/comments/1px0arq/dsip_basically_fixed_my_sleep_apnea_for_a_month/","title":"Dsip basically fixed my sleep apnea for a month","quote":"i used a peptide called \"dsip\" for two days and the rate of me stopping breathing during the night went way down for a solid month as a repercussion.","summary":"User anecdote claiming DSIP temporarily improved sleep apnea symptoms.","author":"","publisher":"","date":"","claim_ids":["c31"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"ok","quote_status":"unverified","prev":"686644a0d57513dad79faca19013018ded55873e390b7853f54533cf2c1880c6","hash":"41221f8f140f224c1e4151852d4d99597db7a7432b7584e79645d867c666d802","source_role":"anecdotal_report"},{"id":"s27","type":"reddit","url":"https://www.reddit.com/r/sleep/comments/1sxdxl9/jumped_from_300_mcg_to_400_mcg_dsip_last_night/","title":"Jumped from 300 mcg to 400 mcg DSIP last night... wow.","quote":"Huge improvement in sleep quality... Much higher quality and deeper sleep and I woke up actually feeling rested","summary":"User reports significant deep sleep improvement at higher DSIP dose.","author":"","publisher":"","date":"","claim_ids":["c32"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"ok","quote_status":"unverified","prev":"41221f8f140f224c1e4151852d4d99597db7a7432b7584e79645d867c666d802","hash":"b851c54cdd093bdd0124021d1c4e79d3f52875f455c31dbc78b23642ed1cffc9","source_role":"anecdotal_report"},{"id":"s28","type":"other","url":"https://en.wikipedia.org/wiki/Delta-sleep-inducing_peptide","title":"Delta-sleep-inducing peptide","quote":"Delta-sleep-inducing peptide (DSIP) is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.","summary":"Wikipedia summary of DSIP discovery, structure, and effects.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:52:13.449Z","link_status":"ok","quote_status":"unverified","prev":"b851c54cdd093bdd0124021d1c4e79d3f52875f455c31dbc78b23642ed1cffc9","hash":"990a778c034e97c134742362b6907f54bb8a0877bd693357645de8519eb44514","source_role":"adjacent_context"},{"id":"s29","type":"medical","url":"https://exploring-peptides.com/article/dsip-peptide-benefits-dosage-side-effects-clinical-data/","title":"DSIP PEPTIDE: Benefits, Dosage, Side Effects & Clinical Data","quote":"This article provides a comprehensive review of DSIP’s biological mechanisms, potential benefits, dosage considerations, comparative efficacy, and current research data.","summary":"2025 review summarizing DSIP research on sleep, stress, pain; notes limited human clinical data and exploratory nature.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:04.962Z","link_status":"ok","quote_status":"verified","prev":"990a778c034e97c134742362b6907f54bb8a0877bd693357645de8519eb44514","hash":"7bec9133a0449ffbfd19bbb09260dcef4069f4a93ffd25266629ff8dbbf1ef61","source_role":"adjacent_context"},{"id":"s30","type":"medical","url":"https://www.phoenixrisingrecovery.com/rehab-blog/dsip-peptide/","title":"DSIP Peptide for Detox","quote":"DSIP, short for Delta Sleep-Inducing Peptide, is a naturally occurring peptide that was first identified in the 1970s.","summary":"June 2026 article on DSIP for opioid withdrawal, stress response, and sleep; references older studies.","author":"","publisher":"","date":"","claim_ids":["c35"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:04.962Z","link_status":"ok","quote_status":"verified","prev":"7bec9133a0449ffbfd19bbb09260dcef4069f4a93ffd25266629ff8dbbf1ef61","hash":"6284cb18a43fb328c423a021eb9391928d6384383c074e1166df7ad0433a96dc","source_role":"adjacent_context"},{"id":"s31","type":"medical","url":"https://rwacenter.com/blog/dsip-the-natural-sleep-architect-for-restorative-rest-and-recovery/","title":"DSIP for Deep Sleep: Benefits, Dosage & Safety","quote":"DSIP (Delta Sleep-Inducing Peptide) is a nine-amino-acid neuropeptide first isolated in the 1970s from the brain tissue of rabbits exhibiting deep delta wave sleep.","summary":"Overview of DSIP for restorative sleep and wellness; discusses mechanisms and research.","author":"","publisher":"","date":"","claim_ids":["c36"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:04.962Z","link_status":"ok","quote_status":"verified","prev":"6284cb18a43fb328c423a021eb9391928d6384383c074e1166df7ad0433a96dc","hash":"388599bf46f5db5328acdf31ae2c6e51f2307614a8d4d6c4049fa389ea67aef0","source_role":"adjacent_context"},{"id":"s32","type":"review","url":"https://luxaralabs.com/dsip-research-review-canada/","title":"DSIP Research Review Canada","quote":"Delta Sleep-Inducing Peptide, commonly abbreviated as DSIP, is a naturally described nonapeptide studied in relation to sleep architecture, delta-wave EEG activity, neuroendocrine signaling, stress-response biology, circadian coordination, and peptide-mediated neuromodulation.","summary":"April 2026 Canadian research review on DSIP sequence, mechanisms, stability for research use.","author":"","publisher":"","date":"","claim_ids":["c37"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:04.962Z","link_status":"ok","quote_status":"verified","prev":"388599bf46f5db5328acdf31ae2c6e51f2307614a8d4d6c4049fa389ea67aef0","hash":"8570c3d560b962a4eddf58bca024227ea9f3e1eed99d0bba093512a71524a325","source_role":"mechanism_support"},{"id":"s33","type":"other","url":"https://podcasts.apple.com/ky/podcast/105-delta-sleep-inducing-peptides/id1578319619?i=1000722424020","title":"105 - Delta Sleep Inducing Peptides –The Matt Walker Podcast","quote":"In this episode, Matt delves into the curious and cautionary tale of Delta Sleep-Inducing Peptide (DSIP), once hailed as a potential miracle cure for insomnia.","summary":"Aug 2025 podcast episode discussing history, promise, and scientific scrutiny of DSIP.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:04.962Z","link_status":"ok","quote_status":"verified","prev":"8570c3d560b962a4eddf58bca024227ea9f3e1eed99d0bba093512a71524a325","hash":"1d4aa5d3b04ad017f0d31ba0bf4002c0dcdf334eb208c494235cba24abc49222","source_role":"adjacent_context"},{"id":"s34","type":"medical","url":"https://www.mdiha.com/blog/peptide-regimens-for-sleep-optimization-and-hormonal-balance","title":"Peptide Regimens for Sleep Optimization and Hormonal Balance","quote":"Delta‑Sleep‑Inducing Peptide ( DSIP ) is the primary peptide that induces sleep by directly deepening delta‑wave activity","summary":"2026 article discusses DSIP science, safety, user experience, mixed reviews from trials, experimental status, not FDA-approved.","author":"","publisher":"","date":"","claim_ids":["c39"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"unverified","prev":"1d4aa5d3b04ad017f0d31ba0bf4002c0dcdf334eb208c494235cba24abc49222","hash":"56d23e25cac814c2dfb1d94ff2d8d6b6d17aa650c7d5596d357145316a0c47d5","source_role":"adjacent_context"},{"id":"s35","type":"medical","url":"https://www.kentonbruicemd.com/blog/best-peptides-for-sleep-what-to-know-before-you-try-them","title":"Best Peptides for Sleep: What to Know Before You Try Them","quote":"Human studies have confirmed that DSIP can reduce sleep onset latency, increase total sleep time, and improve the proportion of time spent in deep, restorative slow-wave sleep","summary":"2026 blog on DSIP for sleep, history, effects on sleep parameters from human studies.","author":"","publisher":"","date":"","claim_ids":["c40"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"verified","prev":"56d23e25cac814c2dfb1d94ff2d8d6b6d17aa650c7d5596d357145316a0c47d5","hash":"9c23a6c4d4180d9a8a01802aa5969889daabc34e717c3e6c4ed593a1aabcafa3","source_role":"adjacent_context"},{"id":"s36","type":"medical","url":"https://healingmaps.com/dsip-delta-sleep-inducing-peptide-emideltide-explained/","title":"DSIP (Delta Sleep Inducing Peptide)","quote":"Regulatory Update (April 2026): DSIP (also referred to as Emideltide) is one of seven peptides scheduled for FDA Pharmacy Compounding Advisory Committee review on July 24, 2026.","summary":"2026 article on DSIP history, uses, FDA review status for compounding in 2026.","author":"","publisher":"","date":"","claim_ids":["c41"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"unverified","prev":"9c23a6c4d4180d9a8a01802aa5969889daabc34e717c3e6c4ed593a1aabcafa3","hash":"6810fa30ad70d96c30d73bc8b90170feaaf53c152d5476d6bd3a4eb4038bd79c","source_role":"adjacent_context"},{"id":"s37","type":"business","url":"https://www.redfoxpeptides.is/dsip-peptide-your-secret-weapon-against-sleepless-nights-canada/","title":"DSIP: The Sleep Peptide That Changes How Canadians Sleep","quote":"DSIP ( Delta Sleep-Inducing Peptide ) is a naturally occurring nonapeptide first isolated in 1977 that helps regulate deep, restorative sleep without the sedative hangover of traditional sleep medications.","summary":"2025 Canadian peptide site article on DSIP benefits, history, mechanism.","author":"","publisher":"","date":"","claim_ids":["c42"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"unverified","prev":"6810fa30ad70d96c30d73bc8b90170feaaf53c152d5476d6bd3a4eb4038bd79c","hash":"dc3bd59086a53293125c2b81741f7ce846590901fc326dc6d33c3cae334ec28b","source_role":"adjacent_context"},{"id":"s38","type":"x","url":"https://x.com/AntiDoc/status/1904576757568545067","title":"X post by @AntiDoc on DSIP sleep benefits","quote":"More/better sleep means more/dramatically better gains. That’s why DSIP is quickly becoming one of my favorite peptides. Ridiculous sleep every night. Ridiculous energy every morning.","summary":"2025 X anecdote on DSIP improving sleep and energy for gains.","author":"","publisher":"","date":"","claim_ids":["c43"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"verified","prev":"dc3bd59086a53293125c2b81741f7ce846590901fc326dc6d33c3cae334ec28b","hash":"34267d6c9383277f0f0c8ec69a65eeec3d8b7f8459dc5ff069308afec419b615","source_role":"anecdotal_report"},{"id":"s39","type":"x","url":"https://x.com/zapmethod/status/2033990620008628244","title":"X post by @zapmethod on DSIP experience","quote":"HOW I WENT FROM RUSSIAN SLEEP EXPERIMENT TO SLEEP LIKE ROCK: ... 100mcg subq before bed ... wake up 9 hours later ... wtf actually dreamed. vivid as hell not groggy. actually refreshed","summary":"2026 detailed X user anecdote on DSIP dramatically improving sleep quality and dreams.","author":"","publisher":"","date":"","claim_ids":["c44"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"unverified","prev":"34267d6c9383277f0f0c8ec69a65eeec3d8b7f8459dc5ff069308afec419b615","hash":"d8afc6d4ff842adb94d778de23a42525e650ec5c9fc462b42f00ca74bd810919","source_role":"anecdotal_report"},{"id":"s40","type":"instagram","url":"https://www.instagram.com/reel/DR0k-o6ge8D/","title":"Instagram reel on DSIP","quote":"DSIP, short for Delta Sleep Inducing Peptide, is a naturally occurring peptide that has been studied for its potential role in supporting healthy sleep ... promotes deeper sleep cycles — including REM and slow-wave sleep.","summary":"2026 Instagram post discussing DSIP for sleep, stress, not FDA-approved, potential side effects.","author":"","publisher":"","date":"","claim_ids":["c45"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:20.326Z","link_status":"ok","quote_status":"unverified","prev":"d8afc6d4ff842adb94d778de23a42525e650ec5c9fc462b42f00ca74bd810919","hash":"ee6069e8f142d917d5999d139cf62c0ec3cfd211c9aabb91af5878807bedde97","source_role":"anecdotal_report"},{"id":"s41","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1t81ivi/dsip_peptide_guide/","title":"DSIP peptide guide","quote":"I was disappointed that DSIP had no effect for me. I tried it two times for the full vial with dosing under the direction of a licensed medical professional, and nothing. I don’t know why.","summary":"User reports no effect after two full vials under medical guidance.","author":"","publisher":"","date":"","claim_ids":["c46"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:40.170Z","link_status":"ok","quote_status":"unverified","prev":"ee6069e8f142d917d5999d139cf62c0ec3cfd211c9aabb91af5878807bedde97","hash":"8d0a0ce1bb7dc91e7d3181fa45e0bc52ed066905c6d21c84be3a261cbc0927ca","source_role":"anecdotal_report"},{"id":"s42","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1t81ivi/dsip_peptide_guide/","title":"DSIP peptide guide","quote":"I slept so hard last night! I'm still tired today, but much more manageable than it usually is. I will cycle 3x a week for 2 weeks to start.","summary":"User with narcolepsy/fibromyalgia reports much more restful sleep after first 100mcg dose.","author":"","publisher":"","date":"","claim_ids":["c47"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:40.170Z","link_status":"ok","quote_status":"unverified","prev":"8d0a0ce1bb7dc91e7d3181fa45e0bc52ed066905c6d21c84be3a261cbc0927ca","hash":"d40462105e42529730873f1230bc14c1f6cc10e1df89fb83bdacb073fa9554a5","source_role":"anecdotal_report"},{"id":"s43","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1ly6cq0/results_of_first_night_of_using_dsip_for_sleep/","title":"Results of FIRST night of using DSIP for sleep. INCREDIBLE!","quote":"I got more restoritive deep sleep in one night than I have in the past 3 days!! My brain feels so just relieved waking up this morning.","summary":"Positive report of dramatically increased deep/restorative sleep from 100-120mcg first dose, tracked via sleep data.","author":"","publisher":"","date":"","claim_ids":["c48"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:40.170Z","link_status":"ok","quote_status":"unverified","prev":"d40462105e42529730873f1230bc14c1f6cc10e1df89fb83bdacb073fa9554a5","hash":"241c7a14604ee473413691c75f0c07d9fa77ae033d5adc39c12e7777b2745d8d","source_role":"anecdotal_report"},{"id":"s44","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1ly6cq0/results_of_first_night_of_using_dsip_for_sleep/","title":"Results of FIRST night of using DSIP for sleep. INCREDIBLE!","quote":"I went through a 5mg vial with no discernable benefits. It's great op is getting such excellent results. Just shows we're all different.","summary":"User reports no benefits after full 5mg vial.","author":"","publisher":"","date":"","claim_ids":["c49"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:40.170Z","link_status":"ok","quote_status":"unverified","prev":"241c7a14604ee473413691c75f0c07d9fa77ae033d5adc39c12e7777b2745d8d","hash":"ce8bc004538e4eab78c9b26e5d9b40ae414538b81a9e713ff0dd44705e63a155","source_role":"anecdotal_report"},{"id":"s45","type":"x","url":"https://x.com/anamarz_amz/status/2068064147854516477","title":"X post by @anamarz_amz","quote":"Ever tried DSIP for sleep? I swear in 10 years of insomnia every night at 2-3 am, this is the only thing that keeps me asleep, brings down my sympathetic tone and other effects. While I can still function through the day.","summary":"User with long-term insomnia reports DSIP as the only thing that keeps them asleep through the night.","author":"","publisher":"","date":"","claim_ids":["c50"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:40.170Z","link_status":"ok","quote_status":"unverified","prev":"ce8bc004538e4eab78c9b26e5d9b40ae414538b81a9e713ff0dd44705e63a155","hash":"49a9a6336f7e392bb3dcb2d1973667637a504681998a1230b5471a3f68d3792a","source_role":"anecdotal_report"},{"id":"s46","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/33918965/","title":"DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl ...","quote":"DSIP-Like KND Peptide Reduces Brain Infarction . When Administered during Reperfusion Biomedicines. Delta-Sleep-Inducing Peptide (DSIP);","summary":"2021 study on DSIP-like peptide reducing brain infarction in mice.","author":"","publisher":"","date":"","claim_ids":["c51"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:52.899Z","link_status":"ok","quote_status":"unverified","prev":"49a9a6336f7e392bb3dcb2d1973667637a504681998a1230b5471a3f68d3792a","hash":"24a7f5bd6dba482558d7719b861a8bcf935cde0be2afe6c842ffa9b202dfb91e","source_role":"mechanism_support"},{"id":"s47","type":"youtube","url":"https://www.youtube.com/watch?v=zG5GKyt0t2U","title":"Delta Sleep Inducing Peptide A comprehensive guide by a ...","quote":"This little-known peptide could be the key to your best night's sleep ever. Learn about the fascinating science behind delta sleep inducing peptide, or DSIP, and how it may unlock deep, restorative slumber.","summary":"2023 YouTube guide on DSIP science and sleep effects by sleep expert.","author":"","publisher":"","date":"","claim_ids":["c52"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:52.899Z","link_status":"http_429","quote_status":"unverified","prev":"24a7f5bd6dba482558d7719b861a8bcf935cde0be2afe6c842ffa9b202dfb91e","hash":"85891dce4c859ab37787789172e00c07143abcc9d119540044a3e93f3d99e836","source_role":"anecdotal_report"},{"id":"s48","type":"reddit","url":"https://www.reddit.com/r/PeptideDiscussion/comments/1gu3fnq/dsip_delta_sleepinducing_peptide/","title":"DSIP : Delta Sleep-Inducing Peptide","quote":"DSIP : Delta Sleep-Inducing Peptide . I'm grasping at straws y'all!! I'm not as bad as some but it's been two days since I have actually gotten ...","summary":"User discussion on DSIP for sleep issues in PeptideDiscussion subreddit.","author":"","publisher":"","date":"","claim_ids":["c53"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:52.899Z","link_status":"ok","quote_status":"unverified","prev":"85891dce4c859ab37787789172e00c07143abcc9d119540044a3e93f3d99e836","hash":"38b5f968b6f190ac8ba77fc0834ccb62578b7649eb39dbf3092fc9a401ca8910","source_role":"anecdotal_report"},{"id":"s49","type":"reddit","url":"https://www.reddit.com/r/PeptideForum/comments/1k74b9j/doctor_offering_dsip_deltasleepinducing_peptide/","title":"Doctor offering DSIP (Delta-sleep-inducing peptide), worth ...","quote":"Doctor offering DSIP ( Delta-sleep-inducing peptide ), worth buying? I have problems with sleep, I take halcion (a benzodiazepine that I wouls ...","summary":"Anecdotal experiences and advice on using DSIP via doctor or gray market.","author":"","publisher":"","date":"","claim_ids":["c54"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:52.899Z","link_status":"ok","quote_status":"unverified","prev":"38b5f968b6f190ac8ba77fc0834ccb62578b7649eb39dbf3092fc9a401ca8910","hash":"70fdf5b5a8f1a8f71a16977e6d74d6bbbf9b4d22a9f71faa050bbeb368f33931","source_role":"anecdotal_report"},{"id":"s50","type":"other","url":"https://peptideslabuk.com/dsip-uk-complete-research-guide-2026/","title":"DSIP UK: Complete Research Guide (2026)","quote":"Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide that has been extensively studied for its effects on sleep ...","summary":"2026 UK guide on DSIP research and effects.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:53:52.899Z","link_status":"ok","quote_status":"unverified","prev":"70fdf5b5a8f1a8f71a16977e6d74d6bbbf9b4d22a9f71faa050bbeb368f33931","hash":"fdcd151f856bd7868ae9136db1d3d067f5b83ec8b125da53bbf956fb96ded4ba","source_role":"adjacent_context"},{"id":"s51","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39444618/","title":"Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models","quote":"Background: Pichia pastoris-secreted delta sleep inducing peptide and crossing the blood-brain barrier peptides ( DSIP -CBBBP) fusion peptides holds significant promise for its potential sleep-enhancing and neurotransmitter balancing effects.","summary":"2024 study on DSIP fusion peptide in mouse insomnia model showing potential for sleep enhancement and neurotransmitter balance.","author":"","publisher":"","date":"","claim_ids":["c56"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:05.234Z","link_status":"ok","quote_status":"unverified","prev":"fdcd151f856bd7868ae9136db1d3d067f5b83ec8b125da53bbf956fb96ded4ba","hash":"8b68c32aaa622ecb3d79d18b8f85eb7a7eb7165ecd9ecc22be346e227dbb1196","source_role":"mechanism_support"},{"id":"s52","type":"reddit","url":"https://www.reddit.com/r/BioHackingGuide/comments/1qv30y1/dsip_peptide_isnt_just_a_sleep_aid/","title":"DSIP peptide isn't “just a sleep aid”","quote":"The main idea is that when DSIP is doing what it's supposed to do, your body shifts more into parasympathetic mode, basically more “rest and ...","summary":"Reddit discussion on DSIP promoting parasympathetic state beyond just sleep.","author":"","publisher":"","date":"","claim_ids":["c57"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:05.234Z","link_status":"ok","quote_status":"unverified","prev":"8b68c32aaa622ecb3d79d18b8f85eb7a7eb7165ecd9ecc22be346e227dbb1196","hash":"5cb2c4d5cf7f05d4d1e5fd1e3621e41c4bf4be8a17dd6b74173905c7575878e3","source_role":"anecdotal_report"},{"id":"s53","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/3550726/","title":"Delta-sleep-inducing peptide (DSIP): an update","quote":"The isolation and characterization of delta-sleep-inducing peptide (DSIP) achieved from 1963 to 1977 were reviewed in 1984. The first reports describing sleep as well as extra-sleep effects of DSIP also were included in that work. Only two years later, much additional literature concerning DSIP has accumulated.","summary":"1986 review updating DSIP literature on sleep and extra-sleep effects, therapeutic potential for insomnia, pain, withdrawal, distribution, and possible adrenergic modulation mechanism.","author":"","publisher":"","date":"","claim_ids":["c58"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:24.806Z","link_status":"ok","quote_status":"verified","prev":"5cb2c4d5cf7f05d4d1e5fd1e3621e41c4bf4be8a17dd6b74173905c7575878e3","hash":"52c848e730020fa7fa0965c285873b169c0ca9d34fba2301d0a320dc741e9e4c","source_role":"mechanism_support"},{"id":"s54","type":"clinical_trial","url":"https://pubmed.ncbi.nlm.nih.gov/6391926/","title":"A clinical trial with DSIP","quote":"In an open study 7 patients with severe insomnia were treated by a series of 10 injections with the delta-sleep-inducing peptide (DSIP). In all but 1 case sleep was normalized for follow-up periods of 3-7 months. The mood and performance during the daytime improved as well.","summary":"1984 open clinical trial of DSIP injections in 7 severe insomnia patients showing sleep normalization in most for months post-treatment.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:24.806Z","link_status":"ok","quote_status":"verified","prev":"52c848e730020fa7fa0965c285873b169c0ca9d34fba2301d0a320dc741e9e4c","hash":"875e9e346efdf0d8c001441cdbecf9b5cb37596139bc51073776bf2406304cf2","source_role":"adjacent_context"},{"id":"s55","type":"medical","url":"https://www.empowersleep.com/articles/delta-sleep-inducing-peptide","title":"Understanding Delta Sleep-Inducing Peptide and Sleep Regulation","quote":"Larger, well-designed clinical trials are needed to clarify whether DSIP has a meaningful role in the management of sleep disorders or other health conditions.","summary":"2026 review of DSIP history, mixed evidence from small trials, lack of identified gene/receptor, and call for more rigorous studies; notes investigational status and no FDA approval.","author":"","publisher":"","date":"","claim_ids":["c60"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:24.806Z","link_status":"ok","quote_status":"verified","prev":"875e9e346efdf0d8c001441cdbecf9b5cb37596139bc51073776bf2406304cf2","hash":"35ff1b4df1030aa7cbf3da8b1114997bd9d34f3746a388db8bf2d15ecf5eb51f","source_role":"adjacent_context"},{"id":"s56","type":"news","url":"https://ssrpinstitute.org/news/fda-announces-change-in-status-of-12-peptides/","title":"FDA Announces Change in Status of 12 Peptides","quote":"the FDA reported today that it will imminently remove the following bulk drug substances from category 2: BPC-157, LL-37, DiHexa, DSIP, Epitalon, *GHK-Cu (injectable only), KPV, PEG-MGF, Melanotan II, MOTs-C, Semax, and TB-500.","summary":"April 2026 news on FDA removing DSIP (Emideltide) and others from Category 2 list, scheduling July 2026 PCAC review for potential compounding approval.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:24.806Z","link_status":"ok","quote_status":"verified","prev":"35ff1b4df1030aa7cbf3da8b1114997bd9d34f3746a388db8bf2d15ecf5eb51f","hash":"539c17412a265e8f51db152bde11edc6d6cedaf08af0cb747a6db14877a43094","source_role":"adjacent_context"},{"id":"s57","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/47jdzp/delta_sleep_inducing_peptide_dsip_for_treating/","title":"Delta Sleep Inducing Peptide (DSIP) for treating central sleep apnea?","quote":"My sleep tracker showed the longest chunks of uninterrupted sleep it's ever shown and I never woke up during the night. Unfortunately, it brought along a friend, insomnia. I usually fall asleep quickly, but after dosing DSIP it took me well over two hours despite being exhausted.","summary":"User reports initial dramatic improvement in uninterrupted deep sleep per tracker but followed by onset insomnia and longer time to fall asleep on subsequent nights.","author":"","publisher":"","date":"","claim_ids":["c62"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:40.209Z","link_status":"ok","quote_status":"unverified","prev":"539c17412a265e8f51db152bde11edc6d6cedaf08af0cb747a6db14877a43094","hash":"3df615071e807cdfd5fbcc7efd63e6ef838f64aa4b42677d68b28d61d02c0002","source_role":"anecdotal_report"},{"id":"s58","type":"reddit","url":"https://www.reddit.com/r/insomnia/comments/1gu3ele/has_anyone_tried_dsipdelta_sleepinducing_peptide/","title":"Has anyone tried DSIP(Delta Sleep-Inducing Peptide)?","quote":"Took a few days for it to really show its effects on me but I get sleepy with in 15-20 mins of taking my dose and I get the best sleep. If I do wake up I go right back to sleep and I have never felt more rested in the morning.","summary":"Positive user experience: quicker sleep onset after a few days, better sleep continuity, feeling more rested.","author":"","publisher":"","date":"","claim_ids":["c63"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:40.209Z","link_status":"ok","quote_status":"unverified","prev":"3df615071e807cdfd5fbcc7efd63e6ef838f64aa4b42677d68b28d61d02c0002","hash":"907521e557240f3829aac1457894f1e7ecbc6ec23c625732324cb5aafda4f5eb","source_role":"anecdotal_report"},{"id":"s59","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/18u5ocg/dsip_delta_sleep_inducing_peptide/","title":"DSIP (delta sleep inducing peptide)","quote":"I used it for 2 months. I didn't notice much. My results may not reflect those seeking this peptide out as my sleep was already dialed in.","summary":"Neutral to negative: no noticeable effects after 2 months of use for a user with already good sleep.","author":"","publisher":"","date":"","claim_ids":["c64"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:40.209Z","link_status":"ok","quote_status":"unverified","prev":"907521e557240f3829aac1457894f1e7ecbc6ec23c625732324cb5aafda4f5eb","hash":"f84681d3906934067c603c8e6e526f0526596f4c4cb3592938f04bf88c1c4130","source_role":"anecdotal_report"},{"id":"s60","type":"x","url":"https://x.com/whey777/status/2069942524815319485","title":"X post by @whey777","quote":"Lastly, when cycling off of GH secretagogues, I decided to try DSIP (delta sleep inducing peptide). Tons of mixed reviews on this one. Personally, it helped me fall and stay asleep, and I did get better deep sleep. But it also made me sleep a bit longer.","summary":"Mixed positive: helped fall asleep, stay asleep, better deep sleep but increased total sleep time.","author":"","publisher":"","date":"","claim_ids":["c65"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:40.209Z","link_status":"ok","quote_status":"verified","prev":"f84681d3906934067c603c8e6e526f0526596f4c4cb3592938f04bf88c1c4130","hash":"312ff5f601ef3bed2ba08d5f169e6a12445f8318b80c0263364bcfc73b7f0484","source_role":"anecdotal_report"},{"id":"s61","type":"x","url":"https://x.com/troywhiteyyc/status/2068891740736503946","title":"X post by @troywhiteyyc","quote":"I started testing out DSIP for sleep management. First night 1mg- no real major difference - 4 hours Second night 1mg - same amount of sleep Third night 1.5mg - 9 hours No idea if the 9 hours was because of higher dose of DSIP, or that I was just exhausted enough from the prior few nights!","summary":"Dose-dependent trial: lower doses no change, higher dose led to much longer sleep (9 hours) after prior poor nights.","author":"","publisher":"","date":"","claim_ids":["c66"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T09:55:40.209Z","link_status":"ok","quote_status":"unverified","prev":"312ff5f601ef3bed2ba08d5f169e6a12445f8318b80c0263364bcfc73b7f0484","hash":"cf11e42f924747eb663cc627f6962628d7ae0724f216b3593ed1f9d0a9132ce6","source_role":"anecdotal_report"},{"id":"s62","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1rakdga/dsip_recovery_and_dreams/","title":"DSIP Recovery and Dreams","quote":"Very recently started DSIP for recovery and it does just that! I don’t feel so sore the next day and get quality sleep-also crazy off the wall dreams.","summary":"Positive user report on improved recovery, sleep quality, and vivid/wild dreams with DSIP use.","author":"","publisher":"","date":"","claim_ids":["c70"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:28.710Z","link_status":"ok","quote_status":"unverified","prev":"cf11e42f924747eb663cc627f6962628d7ae0724f216b3593ed1f9d0a9132ce6","hash":"51a8a1b598cdf93215ed8686fbb7c16292587f79f7bea814983fa718674c6520","source_role":"anecdotal_report"},{"id":"s63","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1rakdga/dsip_recovery_and_dreams/","title":"DSIP Recovery and Dreams","quote":"I just tried it, I dreamt I was selling Holstein cows to a family in Iraq - over the phone. Had another dream I was stealing pink towels from a hotel in China town while my kids ate dumplings on the elevator. I woke up several times, (not new for me) but went back to deep sleep","summary":"Another user's positive/vivid dream experience and ability to return to deep sleep after waking.","author":"","publisher":"","date":"","claim_ids":["c71"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:28.710Z","link_status":"ok","quote_status":"unverified","prev":"51a8a1b598cdf93215ed8686fbb7c16292587f79f7bea814983fa718674c6520","hash":"8233e8475c424a232b73bf594198c1b608f6da0bf8bf839795218043312d08e7","source_role":"anecdotal_report"},{"id":"s64","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1tnualo/peptide_tier_list_for_sleep_ranked_by_sleep/","title":"Peptide tier list for sleep. Ranked by sleep relevance, recovery support, and overall sleep quality","quote":"Svddendemon: Have you taken it? I took a whole bottle and every night I did I got horrible sleep and woke up multiple times through the night.","summary":"Negative experience: poor sleep, frequent awakenings after full course of DSIP.","author":"","publisher":"","date":"","claim_ids":["c72"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:28.710Z","link_status":"ok","quote_status":"unverified","prev":"8233e8475c424a232b73bf594198c1b608f6da0bf8bf839795218043312d08e7","hash":"9400b68ce3e611e7677bce319c5032daa075dc0d8369b666ed491d8a74a29d42","source_role":"anecdotal_report"},{"id":"s65","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1tnualo/peptide_tier_list_for_sleep_ranked_by_sleep/","title":"Peptide tier list for sleep. Ranked by sleep relevance, recovery support, and overall sleep quality","quote":"Taydontplay4: Love DSIP, but I did not initially. I stayed consistent with it and am on my 3rd vial and the magic is happening. It’s almost like my body had an adaptation period to it.","summary":"Positive long-term outcome after initial adaptation period with consistent DSIP use.","author":"","publisher":"","date":"","claim_ids":["c73"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:28.710Z","link_status":"ok","quote_status":"unverified","prev":"9400b68ce3e611e7677bce319c5032daa075dc0d8369b666ed491d8a74a29d42","hash":"1d48057cf8e6d4cee11677ce0d35068a9a15745c873b499e73c10f171d27cc10","source_role":"anecdotal_report"},{"id":"s66","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1tnualo/peptide_tier_list_for_sleep_ranked_by_sleep/","title":"Peptide tier list for sleep. Ranked by sleep relevance, recovery support, and overall sleep quality","quote":"Emmasmom5: DSIP worked but made me feel hung over the next day","summary":"Mixed: effective for sleep but caused next-day hangover-like feeling.","author":"","publisher":"","date":"","claim_ids":["c74"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:28.710Z","link_status":"ok","quote_status":"unverified","prev":"1d48057cf8e6d4cee11677ce0d35068a9a15745c873b499e73c10f171d27cc10","hash":"3303ee8dc6257a2480f122098f7e9aa4299916f75c3e08e0870ec3e1bd706ab2","source_role":"anecdotal_report"},{"id":"s67","type":"anecdotal","url":"https://www.facebook.com/groups/252962560254589/posts/1179093274308175/","title":"DSIP is a peptide to help deep sleep","quote":"DSIP is a peptide to help deep sleep. I'm only on my second day of use but my deep sleep has doubled and happens more often in the night.","summary":"User reports doubling of deep sleep after 2 days of DSIP use, linking to fibromyalgia recovery.","author":"","publisher":"","date":"","claim_ids":["c75"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:51.944Z","link_status":"ok","quote_status":"unverified","prev":"3303ee8dc6257a2480f122098f7e9aa4299916f75c3e08e0870ec3e1bd706ab2","hash":"60189d6ee3214b2bc1104653b54e6fd656b49ae8a3f5483a70d307e64b58e12b","source_role":"anecdotal_report"},{"id":"s68","type":"x","url":"https://x.com/Lions_1776/status/2068064147854516477","title":"X post by @Lions_1776 on DSIP sleep duration","quote":"Have you tried DSIP, Ed? I’m a light sleeper but when using DSIP, I can sleep as long as I like. It’s a nice compound.","summary":"User reports improved ability to sleep longer as a light sleeper with DSIP.","author":"","publisher":"","date":"","claim_ids":["c76"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:51.944Z","link_status":"ok","quote_status":"verified","prev":"60189d6ee3214b2bc1104653b54e6fd656b49ae8a3f5483a70d307e64b58e12b","hash":"c158bd7e1f7c85d52600496a8f2ef44694f4af003ca934c4610dd9ffd616cc17","source_role":"anecdotal_report"},{"id":"s69","type":"x","url":"https://x.com/FattyNoNatty/status/2067706289006985373","title":"X post by @FattyNoNatty on DSIP experience","quote":"You know, I've heard that- I tried DSIP, and I did notice a difference.. but when you just start getting good sleep it doesn't make sense to just keep adding stuff.","summary":"Mildly positive anecdotal report of noticing a difference in sleep with DSIP.","author":"","publisher":"","date":"","claim_ids":["c77"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:51.944Z","link_status":"ok","quote_status":"unverified","prev":"c158bd7e1f7c85d52600496a8f2ef44694f4af003ca934c4610dd9ffd616cc17","hash":"606922cda08e055d069002f4e609df83e3c793ad1e108f1c0b6ccb0a8c382e6a","source_role":"anecdotal_report"},{"id":"s70","type":"reddit","url":"https://www.reddit.com/r/DSPD/comments/pnpial/had_anyone_tried_dsip_peptide_to_reset_their/","title":"Had anyone tried DSIP peptide to reset their circadian rhythm?","quote":"My sleep cycle is roughly 5am-1pm. I can happily fall asleep later than 5am and wake at 3pm, but this is the best I’ve been able to manage so far.","summary":"User seeking experiences with DSIP for circadian rhythm issues; describes personal sleep pattern but no outcome reported in snippet.","author":"","publisher":"","date":"","claim_ids":["c78"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:35:51.944Z","link_status":"ok","quote_status":"unverified","prev":"606922cda08e055d069002f4e609df83e3c793ad1e108f1c0b6ccb0a8c382e6a","hash":"b75c4c533e7f75c32a54feca0ca658aeae59d39d4b0b2caf92d7f6a681dcdc3c","source_role":"anecdotal_report"},{"id":"s71","type":"x","url":"https://x.com/Chrissssjohnson/status/2008202115186147361","title":"X post on DSIP fixing sleep schedule","quote":"My sleep schedule has been cooked since I came home from Iraq war 14 years ago \n\n14 years of needing sleeping pills to go to sleep\n\nNow, I get sleepy naturally around 9/10 and wake up well rested around 5-6\n\nCircadian rhythm fixed","summary":"Positive user experience: DSIP restored natural sleep schedule and circadian rhythm after long-term issues.","author":"","publisher":"","date":"","claim_ids":["c79"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:36:15.578Z","link_status":"ok","quote_status":"verified","prev":"b75c4c533e7f75c32a54feca0ca658aeae59d39d4b0b2caf92d7f6a681dcdc3c","hash":"4b687ec463fb81c203bd53ae9e81615f956ab0384e512347864bbc88544af5e5","source_role":"anecdotal_report"},{"id":"s72","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1shazrp/dsip_experience/","title":"Dsip experience","quote":"I tried dsip for the first time last night. I went to bed at midnight but woke up at 5 a.m., so much earlier than expected, and my sleep quality felt worse. Is that normal?","summary":"User reports worse sleep and early waking after first DSIP use; comments include ruined sleep, barely slept, next-day fatigue/paralysis, and lower HRV.","author":"","publisher":"","date":"","claim_ids":["c80"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:36:44.744Z","link_status":"ok","quote_status":"unverified","prev":"4b687ec463fb81c203bd53ae9e81615f956ab0384e512347864bbc88544af5e5","hash":"974eb77d6feb129d0ae9c756c4ab0a25ec9ce09263c6d4ad22ac7b9736da4f37","source_role":"anecdotal_report"},{"id":"s73","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1tca76g/peptides_for_sleep_sleep_maintenance_insomnia/","title":"Peptides for Sleep (Sleep Maintenance Insomnia)","quote":"I’ve tried DSIP and it was horrible for me - I slept probably 4 hours. Only benefit was I wasn’t tired the following day.","summary":"OP reports poor outcome (only 4h sleep); other users report zero wake-ups, best sleeps, return of dreaming, high sleep scores post-protocol.","author":"","publisher":"","date":"","claim_ids":["c81"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:36:44.744Z","link_status":"ok","quote_status":"unverified","prev":"974eb77d6feb129d0ae9c756c4ab0a25ec9ce09263c6d4ad22ac7b9736da4f37","hash":"c2f564cf3e963fd060d62c16d55ad599af7c23b0767807eb344b9962f397a284","source_role":"anecdotal_report"},{"id":"s74","type":"reddit","url":"https://www.reddit.com/r/BodyHackGuide/comments/1uhio7j/i_wish_id_discovered_dsip_for_sleep_earlier/","title":"I wish I'd discovered DSIP for sleep earlier","quote":"I've been struggling to get anything more than 3-5 hours of sleep for the half year due to Post Alcohol Withdrawal Syndrome, but I recently added DSIP into my recovery stack and I feel that my sleep has been even better than it was before I ever drank. I'm getting anywhere from 7-9 hours of sleep per night since getting DSIP - but even better is the return of my dreams. They're vivid and memorable now","summary":"Strong positive: improved from 3-5h to 7-9h sleep, vivid memorable dreams, mental rejuvenation after PAWS insomnia.","author":"","publisher":"","date":"","claim_ids":["c82"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:36:44.744Z","link_status":"ok","quote_status":"unverified","prev":"c2f564cf3e963fd060d62c16d55ad599af7c23b0767807eb344b9962f397a284","hash":"b67b7d2b30434a1ff93bf9928565e7f7850cd71122a174de8873f11c65963ab6","source_role":"anecdotal_report"},{"id":"s75","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1p1fbgq/dsip_delta_sleepinducing_peptide_better_deep/","title":"DSIP 💤 (Delta Sleep-Inducing Peptide) Better Deep Sleep | Cortisol Balance | CNS Recovery","quote":"It’s quieter. More structural. Almost invisible until you notice you’re not waking up three times a night anymore. ... Week 2–3: Sleep gets deeper. Dreams get a little heavier. You wake up clearer — not energized, just not foggy.","summary":"Describes gradual benefits: fewer awakenings, deeper sleep, heavier dreams, clearer mornings; subtle structural improvement rather than sedation.","author":"","publisher":"","date":"","claim_ids":["c83"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:36:44.744Z","link_status":"ok","quote_status":"unverified","prev":"b67b7d2b30434a1ff93bf9928565e7f7850cd71122a174de8873f11c65963ab6","hash":"b7433ff819a5c0cfa5f4e63c53dad6d0cb199cc26bd20b0b22b06ca0c5b0b448","source_role":"anecdotal_report"},{"id":"s76","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1bqdrof/im_trying_dsip_for_the_first_time_tonight_does/","title":"Im trying DSIP for the first time tonight, does anyone have any experience? (From my DR)","quote":"I’ve been taking DSIP for about five days now, and I think it’s actually making my deep sleep worse. At first, I was getting around 45 minutes of deep sleep each night and was hoping to improve that. But by the fifth day, I only got 8 minutes.","summary":"User reports negative impact on deep sleep after several days of DSIP use; other commenters share mixed positive experiences with deeper sleep and feeling more rested.","author":"","publisher":"","date":"","claim_ids":["c84"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:37:37.862Z","link_status":"ok","quote_status":"unverified","prev":"b7433ff819a5c0cfa5f4e63c53dad6d0cb199cc26bd20b0b22b06ca0c5b0b448","hash":"0b8e1fc338ed35499d04c3e219b5bf0b666376b702235a52a233f96a8962347b","source_role":"anecdotal_report"},{"id":"s77","type":"reddit","url":"https://www.reddit.com/r/Peptidesource/comments/1ps5lgw/what_was_your_experience_with_dsips/","title":"What Was Your Experience With DSIPS?","quote":"DSiP literally gave me insomnia the two nights I used it.","summary":"Multiple user reports: negative experiences include insomnia or no effect; positive include deeper sleep, fewer awakenings, and better rest quality, especially when cycled.","author":"","publisher":"","date":"","claim_ids":["c85"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:37:37.862Z","link_status":"ok","quote_status":"unverified","prev":"0b8e1fc338ed35499d04c3e219b5bf0b666376b702235a52a233f96a8962347b","hash":"b5e4594aeab4837db27512fc7c1a9e2699bd4672c9dc626317981cde5499d48a","source_role":"anecdotal_report"},{"id":"s78","type":"reddit","url":"https://www.reddit.com/r/BodyHackGuide/comments/1tylecq/dsip_works_but_requires_patience/","title":"DSIP works, but requires patience","quote":"DSIP completely transformed my sleep but not in the way I expected (stick with it) ... When I first started, I actually had a harder time falling asleep. ... around the three-week mark something shifted. My entire sleep architecture just changed. I started hitting what feels like genuinely deep, restorative sleep ... Now I'm a few months in and I haven't noticed any tolerance buildup ... Dose: 300-500mcg SubQ nightly","summary":"User reports initial difficulty falling asleep but after 3 weeks, dramatically improved deep/restorative sleep, vivid dreams, no tolerance after months; recommends patience and 300-500mcg dose. Mixed comments: some saw benefits after adjustment or timing change (e.g. deeper sleep %), others no effect or quit early.","author":"","publisher":"","date":"","claim_ids":["c86"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:38:02.900Z","link_status":"ok","quote_status":"unverified","prev":"b5e4594aeab4837db27512fc7c1a9e2699bd4672c9dc626317981cde5499d48a","hash":"a0a1b3522f2e0a9ae407314c3bd3da69dc393759b0c508e2da242d40996c2ffc","source_role":"anecdotal_report"},{"id":"s79","type":"x","url":"https://x.com/GiffenHealth/status/2068891740736503946","title":"Peptide #26: DSIP","quote":"Peptide #26: DSIP Deep sleep inducer. The one that actually gives you restorative rest without grogginess. Underrated king for anyone whose recovery sucks.","summary":"User describes DSIP as providing restorative deep sleep without grogginess, great for recovery.","author":"","publisher":"","date":"","claim_ids":["c87"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:38:02.900Z","link_status":"ok","quote_status":"verified","prev":"a0a1b3522f2e0a9ae407314c3bd3da69dc393759b0c508e2da242d40996c2ffc","hash":"046709a34dfd673702ed4f717f60a69156f5666485de85e887e1f705beff6c89","source_role":"anecdotal_report"},{"id":"s80","type":"x","url":"https://x.com/TalkingCry97534/status/2071051909964685532","title":"DSIP Spotlight","quote":"DSIP Spotlight: The Delta Sleep-Inducing Peptide. Achieve deeper REM cycles and superior recovery with enhanced sleep architecture.","summary":"Promotional post highlighting deeper REM and recovery benefits from DSIP.","author":"","publisher":"","date":"","claim_ids":["c88"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:38:02.900Z","link_status":"ok","quote_status":"verified","prev":"046709a34dfd673702ed4f717f60a69156f5666485de85e887e1f705beff6c89","hash":"aebe19fa50fffb61415229f7e86c6668935f123dc29730de03ec1f09a3f1af7f","source_role":"anecdotal_report"},{"id":"s81","type":"reddit","url":"https://www.reddit.com/r/BodyOptimization/comments/1p5mc7j/dsip_selank_how_i_leveled_up_my_sleep/","title":"DSIP + Selank: How I Leveled Up My Sleep","quote":"When I paired the two together, I fell asleep faster because my mind was calmer, my sleep felt heavier and more restorative, I woke up fewer times, and I woke up feeling fresh instead of groggy. My heart rate was smoother throughout the night, deep sleep scores increased consistently, I recovered better from training, and I felt more mentally stable during the day.","summary":"User anecdote on stacking DSIP (200mcg) with Selank (500mcg) before bed for improved deep sleep, fewer interruptions, and better recovery. Anecdotal, not advice.","author":"","publisher":"","date":"","claim_ids":["c93"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:35:46.840Z","link_status":"ok","quote_status":"unverified","prev":"aebe19fa50fffb61415229f7e86c6668935f123dc29730de03ec1f09a3f1af7f","hash":"42628a5ac67ea9be9817d48cbf568bfa8d62bcb88e5fcc5b954619c8ab831ff8","source_role":"anecdotal_report"},{"id":"s82","type":"reddit","url":"https://www.reddit.com/r/BodyOptimization/comments/1p5mc7j/dsip_selank_how_i_leveled_up_my_sleep/","title":"DSIP + Selank: How I Leveled Up My Sleep","quote":"200mcg of DSIP and 500mcg Selank about an hour or an hour and a half so before bed","summary":"Dosing anecdote from OP reply: 200mcg DSIP + 500mcg Selank ~1-1.5h before bed. Anecdotal, not advice.","author":"","publisher":"","date":"","claim_ids":["c94"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:35:46.840Z","link_status":"ok","quote_status":"unverified","prev":"42628a5ac67ea9be9817d48cbf568bfa8d62bcb88e5fcc5b954619c8ab831ff8","hash":"a25b1fbc08c89f6093dd9d0bb52022341c5095fd3cdaa5c251ff720c9e8da04c","source_role":"anecdotal_report"},{"id":"s83","type":"reddit","url":"https://www.reddit.com/r/Biohack_Blueprint/comments/1ufcu8a/spotlight_dsip_is_not_just_a_sleep_peptide_the/","title":"Spotlight: DSIP is not just a sleep peptide. The HPA axis story is the bigger story.","quote":"Typical protocols use 100 to 200 mcg per night, taken 30 to 60 minutes before bed. Most people see effects within 1 to 2 weeks. Full HPA recalibration takes 4 to 8 weeks of consistent use.","summary":"Post discusses DSIP beyond sleep for HPA axis/stress regulation, with dosing context (100-200mcg/night). Anecdotal framing in community, not advice.","author":"","publisher":"","date":"","claim_ids":["c95"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:35:46.840Z","link_status":"ok","quote_status":"unverified","prev":"a25b1fbc08c89f6093dd9d0bb52022341c5095fd3cdaa5c251ff720c9e8da04c","hash":"153114f973977741aee47a8e16d540a639a2050e10ec2e8070112d374e1c1b81","source_role":"anecdotal_report"},{"id":"s84","type":"x","url":"https://x.com/sleepdiplomat/status/1957519423457358246","title":"Delta Sleep Inducing Peptides - The Matt Walker Podcast","quote":"In this episode, Matt delves into the curious and cautionary tale of Delta Sleep-Inducing Peptide (DSIP), once hailed as a potential miracle...","summary":"X post linking podcast on DSIP history as potential sleep aid with cautionary notes on evidence.","author":"","publisher":"","date":"","claim_ids":["c96"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:35:46.840Z","link_status":"ok","quote_status":"unverified","prev":"153114f973977741aee47a8e16d540a639a2050e10ec2e8070112d374e1c1b81","hash":"9a690aedd8ae7d6fb771c755e965732a5f89a18920129ebbcea983763b92da77","source_role":"anecdotal_report"},{"id":"s85","type":"x","url":"https://x.com/TKubowitz9tdk/status/2071444996562227309","title":"","quote":"The peptide DSIP may help those already in trouble. Also helps with alcohol, benzodiazepines, opiates and kratom.","summary":"X post anecdotal claim on DSIP for withdrawal/stress issues. Anecdotal, not advice.","author":"","publisher":"","date":"","claim_ids":["c97"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:35:46.840Z","link_status":"ok","quote_status":"verified","prev":"9a690aedd8ae7d6fb771c755e965732a5f89a18920129ebbcea983763b92da77","hash":"5552b59a84ae6520a667c7c53b6ca113532ee4979b4465c8ca57b558020a31bc","source_role":"anecdotal_report"},{"id":"s86","type":"reddit","url":"https://www.reddit.com/r/Ameano_Peptides/comments/1ocobsd/a_complete_guide_for_dsip/","title":"A Complete Guide for DSIP","quote":"DSIP ( Delta Sleep-Inducing Peptide ) is a naturally-occurring nonapeptide found in the brain and other tissues, offered by Ameano Peptides in a research-grade formulation.","summary":"Promotional guide post on DSIP mechanism for sleep regulation; anecdotal dosing not detailed here but notes research compound only, not for human consumption.","author":"","publisher":"","date":"","claim_ids":["c98"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:36:11.020Z","link_status":"ok","quote_status":"unverified","prev":"5552b59a84ae6520a667c7c53b6ca113532ee4979b4465c8ca57b558020a31bc","hash":"0da395d1567a060afb3857f1dcaf164194b065177806157e9e62d7c79cfa4e0e","source_role":"anecdotal_report"},{"id":"s87","type":"reddit","url":"https://www.reddit.com/r/ADHDers/comments/1shiytb/delta_sleepinducing_peptide_dsip_did_it_affect/","title":"Delta Sleep-Inducing Peptide (DSIP) — did it affect your prescription stimulants?","quote":"I have no experience of or knowledge of DSIP.","summary":"Thread asking about DSIP interaction with ADHD meds; one comment notes no experience.","author":"","publisher":"","date":"","claim_ids":["c99"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:36:11.020Z","link_status":"ok","quote_status":"unverified","prev":"0da395d1567a060afb3857f1dcaf164194b065177806157e9e62d7c79cfa4e0e","hash":"587aebc719804f082c056d9b6c5ad410e57797b99a4017b2ce12389114af21b9","source_role":"anecdotal_report"},{"id":"s88","type":"x","url":"https://x.com/HillaryLinMD/status/2071602085401866272","title":"Are peptides back?","quote":"Emideltide / DSIP: D+ for sleep/withdrawal/pain","summary":"MD post on FDA discussion of DSIP (Emideltide) evidence grade D+ for sleep; notes evidence issues but not zero.","author":"","publisher":"","date":"","claim_ids":["c100"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:36:11.020Z","link_status":"ok","quote_status":"verified","prev":"587aebc719804f082c056d9b6c5ad410e57797b99a4017b2ce12389114af21b9","hash":"79d66facf2af220caa36c59750a7c0c54064990a90e6b83f649b4182f618b510","source_role":"anecdotal_report"},{"id":"s89","type":"x","url":"https://x.com/xiipercent/status/2071641514263130279","title":"DSIP experience with blend","quote":"I def feel from DSIP 10mg ; +a tesa/ipa 10/10mg blend. I feel like my own anesthesiologist- straight to sleep.","summary":"Anecdotal positive: DSIP 10mg with blend leads to immediate sleep (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c101"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:36:11.020Z","link_status":"ok","quote_status":"verified","prev":"79d66facf2af220caa36c59750a7c0c54064990a90e6b83f649b4182f618b510","hash":"5e10dd02770ad71498f79f6bc8ed317fd137484fc31ef3410bdcecfe1db62abc","source_role":"anecdotal_report"},{"id":"s90","type":"x","url":"https://x.com/PeptideBuz/status/2071576099931459677","title":"Peptide FDA discussion","quote":"July 24: Emideltide (DSIP), Semax, Epitalon. Seven peptides total. These aren't being \"approved\" — they're being evaluated for return to Category 1 compounding status.","summary":"Update on potential regulatory changes for DSIP (Emideltide); context for user interest in sourcing and effects.","author":"","publisher":"","date":"","claim_ids":["c102"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:36:42.491Z","link_status":"ok","quote_status":"unverified","prev":"5e10dd02770ad71498f79f6bc8ed317fd137484fc31ef3410bdcecfe1db62abc","hash":"4a002f029967c5e0ef9c9b62efd623eaac9138fab934e8339128bf6e9a3dc3ff","source_role":"anecdotal_report"},{"id":"s91","type":"x","url":"https://x.com/xiipercent/status/2071614893732900958","title":"DSIP stack mention","quote":"DSIP. + tesa/ipa blend. your welcome","summary":"User recommending DSIP stack for sleep (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c103"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:37:21.925Z","link_status":"ok","quote_status":"verified","prev":"4a002f029967c5e0ef9c9b62efd623eaac9138fab934e8339128bf6e9a3dc3ff","hash":"9aec603d07f0559780f3e69d99813cc92546bc0d2f300e1f7f4f4e6597fc36aa","source_role":"anecdotal_report"},{"id":"s92","type":"x","url":"https://x.com/AMRadio84/status/2071613491719319677","title":"DSIP sourcing anecdote","quote":"Same here. Grok ruined my Epithalon & DSIP into Peptides. Had to toss them now I use a well known influencer cheat sheet. All is well.","summary":"Anecdotal mention of discarding DSIP due to sourcing concerns (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c104"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:37:21.925Z","link_status":"ok","quote_status":"unverified","prev":"9aec603d07f0559780f3e69d99813cc92546bc0d2f300e1f7f4f4e6597fc36aa","hash":"54b12eb0f7a7192defb6364197ac55671f7e7bcb40d9010b8fd19ac4c196aba0","source_role":"anecdotal_report"},{"id":"s93","type":"reddit","url":"https://www.reddit.com/r/sleep/comments/1l1zbhz/actual_peptides_meds_that_will_give_you_deep_sleep/","title":"Actual peptides / meds that will give you deep sleep?","quote":"YMMV. I've had the worst insomnia from it, tried different brands and dosages over the years. On par with melatonin.. and other 100+ supplements / meds / peptides that either do nothing or worsen my sleep","summary":"User reports worst insomnia from DSIP, tried multiple brands/doses (anecdotal, not advice). Others note it worsened sleep or affected REM differently.","author":"","publisher":"","date":"","claim_ids":["c105"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:38:00.166Z","link_status":"ok","quote_status":"unverified","prev":"54b12eb0f7a7192defb6364197ac55671f7e7bcb40d9010b8fd19ac4c196aba0","hash":"71f59822bfe3ba6c19f511aa2f541a1c36512554d6980dc7a3a32ccbbc31bac9","source_role":"anecdotal_report"},{"id":"s94","type":"reddit","url":"https://www.reddit.com/r/sleep/comments/1l1zbhz/actual_peptides_meds_that_will_give_you_deep_sleep/","title":"Actual peptides / meds that will give you deep sleep?","quote":"Yeah it made my sleep worse I tried it 3 times.","summary":"Comment: DSIP made sleep worse after 3 attempts (anecdotal).","author":"","publisher":"","date":"","claim_ids":["c106"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:38:00.166Z","link_status":"ok","quote_status":"unverified","prev":"71f59822bfe3ba6c19f511aa2f541a1c36512554d6980dc7a3a32ccbbc31bac9","hash":"beb86c59eb10e9f6c9ab6b20ed1aea09988a1813b1a5be97de1f80a6547ff1a7","source_role":"anecdotal_report"},{"id":"s95","type":"reddit","url":"https://www.reddit.com/r/sleep/comments/1l1zbhz/actual_peptides_meds_that_will_give_you_deep_sleep/","title":"Actual peptides / meds that will give you deep sleep?","quote":"Same here. DSIP shots made my sleep a lot worse","summary":"Another user confirms DSIP worsened sleep (anecdotal).","author":"","publisher":"","date":"","claim_ids":["c107"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:38:00.166Z","link_status":"ok","quote_status":"unverified","prev":"beb86c59eb10e9f6c9ab6b20ed1aea09988a1813b1a5be97de1f80a6547ff1a7","hash":"9ecd0b792b2928d9161ffe961cfc54598b9da516d25ab1a2d5389ccdc80bb5be","source_role":"anecdotal_report"},{"id":"s96","type":"reddit","url":"https://www.reddit.com/r/sleep/comments/1l1zbhz/actual_peptides_meds_that_will_give_you_deep_sleep/","title":"Actual peptides / meds that will give you deep sleep?","quote":"I take it and it does not affect sleep time or deep sleep but no matter how little sleep I get, there is always REM and that was not the case pre-DSIP.","summary":"Positive for REM consistency despite no change in deep sleep duration (anecdotal).","author":"","publisher":"","date":"","claim_ids":["c108"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:38:00.166Z","link_status":"ok","quote_status":"unverified","prev":"9ecd0b792b2928d9161ffe961cfc54598b9da516d25ab1a2d5389ccdc80bb5be","hash":"8746b6b9f7cd4958752899f4823c0258de749a6b29e63d23bbe01aa125eecb98","source_role":"anecdotal_report"},{"id":"s97","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1nnfj2w/dsip_intranasalsubq_complete_opiate_withdrawal/","title":"DSIP Intranasal/Sub-Q Complete Opiate Withdrawal Relief","quote":"Current dosage is about 1mg at a time sub-q or 50mcg per nostril. ... Sub-q DSIP provides sustained complete withdrawal relief. Intranasal provides more rapid and pronounced, but shorter lived withdrawal relief.","summary":"Anecdotal report (not advice) of DSIP at 1mg subq or 50mcg intranasal providing complete opiate withdrawal relief and reversing tolerance/dependence; good outcome noted.","author":"","publisher":"","date":"","claim_ids":["c109"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:38:24.650Z","link_status":"ok","quote_status":"unverified","prev":"8746b6b9f7cd4958752899f4823c0258de749a6b29e63d23bbe01aa125eecb98","hash":"e11afda2b5ab2ff53a76da2094290c87d0632d39659c2700785ba6c3d204bae6","source_role":"anecdotal_report"},{"id":"s98","type":"reddit","url":"https://www.reddit.com/r/Biohacking/comments/1rwy37j/how_long_does_a_reconstituted_dsip_vial_actually/","title":"How long does a reconstituted DSIP vial actually last in the fridge?","quote":"I’m running 250 mcg (6.25 units on a U-100 syringe) Monday through Friday and taking weekends off. ... First night (250 mcg DSIP): slept over 6 hours — super smooth and consolidated the whole way... 250 mcg was clearly the winner my overall rest and recovery","summary":"User shares anecdotal dosing (250 mcg nightly M-F) and positive sleep outcomes with DSIP, notes titration and vial storage experiences; labels as research use only.","author":"","publisher":"","date":"","claim_ids":["c110"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:39:34.774Z","link_status":"ok","quote_status":"unverified","prev":"e11afda2b5ab2ff53a76da2094290c87d0632d39659c2700785ba6c3d204bae6","hash":"fe3788435ff5887a3349ad1ab88dc021dbc9631f008e4263a8efa6669c9820a7","source_role":"anecdotal_report"},{"id":"s99","type":"reddit","url":"https://www.reddit.com/r/APRHealthSolutions/comments/1q56i5l/dsip_comprehensive_guide/","title":"DSIP: Comprehensive Guide","quote":"DSIP is commonly studied for: Deep sleep and slow-wave sleep enhancement. Nighttime recovery and regeneration. Stress and overtraining models.","summary":"Guide on DSIP as research compound for sleep architecture, stress, recovery; anecdotal community mentions implied but focused on research context.","author":"","publisher":"","date":"","claim_ids":["c111"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:39:34.774Z","link_status":"ok","quote_status":"unverified","prev":"fe3788435ff5887a3349ad1ab88dc021dbc9631f008e4263a8efa6669c9820a7","hash":"a3a06e4b89d68b8910006140b6aa7608b2173074cc40716deb40cbb6c9c7a552","source_role":"anecdotal_report"},{"id":"s100","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/h0j7cv/dsip_delta_sleep_inducing_peptide_no_effect/","title":"DSIP ( delta sleep inducing peptide ): no effect whatsoever","quote":"DSIP ( delta sleep inducing peptide ): no effect whatsoever. I've tried 125mcg (day time) and ~300mcg (pre sleep). I felt no effects at all ...","summary":"Anecdotal report of no effects from DSIP at tested doses (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c112"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:39:55.122Z","link_status":"ok","quote_status":"unverified","prev":"a3a06e4b89d68b8910006140b6aa7608b2173074cc40716deb40cbb6c9c7a552","hash":"87515a046eec365cf76437c79cc8d53184457f62dbb45e54b55a063531b034a0","source_role":"anecdotal_report"},{"id":"s101","type":"reddit","url":"https://www.reddit.com/r/sleephackers/comments/1ag716c/any_personal_experience_with_dsip_delta/","title":"any personal experience with DSIP (Delta Sleep-Inducing Peptide)?","quote":"I am sleeping through the night MUCH better after a few doses of DSIP.","summary":"Anecdotal positive outcome for sleep maintenance with DSIP (anecdotal, not advice); user cycles every other night.","author":"","publisher":"","date":"","claim_ids":["c113"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:39:55.122Z","link_status":"ok","quote_status":"unverified","prev":"87515a046eec365cf76437c79cc8d53184457f62dbb45e54b55a063531b034a0","hash":"2ced98ecb586e62689dd885b9c5ef39bc41a407307df0059e2acd7f7cfcbe7d5","source_role":"anecdotal_report"},{"id":"s102","type":"x","url":"https://x.com/gr8tful88/status/2071404994192974208","title":"X post listing peptides including DSIP","quote":"Sleep: DSIP, Epitalon.","summary":"Lists DSIP for sleep in peptide overview.","author":"","publisher":"","date":"","claim_ids":["c114"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:40:18.338Z","link_status":"ok","quote_status":"verified","prev":"2ced98ecb586e62689dd885b9c5ef39bc41a407307df0059e2acd7f7cfcbe7d5","hash":"1d7e25d9cc522f346e1092132e1d97ec4c266d450de86d3c8847911d3827d265","source_role":"anecdotal_report"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7405185/","title":"Effect of delta sleep inducing peptide (DSIP) and arginine vasotocin (AVT) on sleep and motor activity in the rat — Tobler I, Borbely AA. Waking Sleeping. 1980;4(2):139-53. PMID 7405185","quote":"It is concluded that neither DSIP nor AVT qualify as a specific sleep-promoting substance.","_id":"w_jrk3aijc","_ts":"2026-08-04T08:28:26.330Z","id":"w_jrk3aijc","type":"source","accessed_at":"2026-08-04T08:28:26.330Z","claim_ids":[],"prev":"1d7e25d9cc522f346e1092132e1d97ec4c266d450de86d3c8847911d3827d265","hash":"52392cc66ad8dfbf1df9fb01bf90623805e953f8e50a2f23492ff3f6f18ff373","plain":"Rats, and an early failure to replicate. Two candidate sleep substances were run side by side and the authors refused the label for both - from a leading sleep laboratory, only a few years after the original claim was made."},{"url":"https://pubmed.ncbi.nlm.nih.gov/265572/","title":"Characterization of a delta-electroencephalogram (-sleep)-inducing peptide — Schoenenberger GA, Monnier M. Proc Natl Acad Sci USA. 1977;74(3):1282-6. PMID 265572","quote":"Amino acid sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. A total of 58 rabbits including controls were evaluated. Only the delta-sleep-inducing peptide (synthetic) showed significant and specific enhancement/induction of delta and spindle electroencephalogram patterns.","_id":"w_y3chk0t1","_ts":"2026-08-04T08:29:41.006Z","id":"w_y3chk0t1","type":"source","accessed_at":"2026-08-04T08:29:41.006Z","claim_ids":[],"prev":"52392cc66ad8dfbf1df9fb01bf90623805e953f8e50a2f23492ff3f6f18ff373","hash":"5209883b98d39dfa789b1c81a7fe59c12bf158357dbfdabb51dbe5289397af4f","plain":"The founding paper: it named the peptide and gave its nine-amino-acid sequence from rabbit work. Everything downstream rests on this - and the group that proposed the substance is the group that tested it, in 1977, using brainwave traces."},{"url":"https://pubmed.ncbi.nlm.nih.gov/1237876/","title":"Humoral transmission of sleep IX: activity and concentration of the sleep peptide delta in cerebral and systemic blood fractions — Monnier M, Dudler L, Gachter R, Schoenenberger GA. Pflugers Arch. 1975;360(3):225-42. PMID 1237876","quote":"The electric thalamic stimulation of donors, with parameters inducing orthodox delta-sleep, parallely increases the delta peptide concentration (160 nM/g) and its activity (543 muV x sec delta integral) in cerebral blood dialysate.","_id":"w_hroqdqlk","_ts":"2026-08-04T08:29:41.315Z","id":"w_hroqdqlk","type":"source","accessed_at":"2026-08-04T08:29:41.315Z","claim_ids":[],"prev":"5209883b98d39dfa789b1c81a7fe59c12bf158357dbfdabb51dbe5289397af4f","hash":"623cb77cdb27027bd031fdf5e3decce3e79d269f47eba77cbd56608ccea3b347","plain":"Where the idea began. Fluid drawn from rabbits whose brains were being electrically driven into deep sleep carried more of the substance and more of the effect - a correlation, measured on 1975 equipment, in animals not sleeping on their own."},{"url":"https://pubmed.ncbi.nlm.nih.gov/568769/","title":"The delta EEG (sleep)-inducing peptide (DSIP) XI: amino-acid analysis, sequence, synthesis and activity of the nonapeptide — Schoenenberger GA, Maier PF, Tobler HJ, Wilson K, Monnier M. Pflugers Arch. 1978;376(2):119-29. PMID 568769","quote":"The mean increase of EEG delta activity reached 35% in the neocortex and limbic cortex as compared to control animals receiving CSF-like solution or any of the other 8 peptides.","_id":"w_1v4zebwc","_ts":"2026-08-04T08:29:41.776Z","id":"w_1v4zebwc","type":"source","accessed_at":"2026-08-04T08:29:41.776Z","claim_ids":[],"prev":"623cb77cdb27027bd031fdf5e3decce3e79d269f47eba77cbd56608ccea3b347","hash":"8593944afa55656b9d45ad8d916ed5d617031e25c1fe3ada88c1b1e3597d6376","plain":"The synthesis paper from the same laboratory: a chemically built version tested against eight other peptides and a blank solution. The brainwave shift is modest in size, and every comparison is internal to the group that proposed the peptide."},{"url":"https://pubmed.ncbi.nlm.nih.gov/3583493/","title":"Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs — Monti JM, Debellis J, Alterwain P, Pellejero T, Monti D. Int J Clin Pharmacol Res. 1987;7(2):105-10. PMID 3583493","quote":"For NREM sleep time and stage 2 sleep differences between DSIP and a placebo were significant, but the same differences existed already for the baseline values. It can be concluded that sleep improvement under DSIP treatment is of little clinical significance.","_id":"w_pkhu2ho3","_ts":"2026-08-04T08:29:42.081Z","id":"w_pkhu2ho3","type":"source","accessed_at":"2026-08-04T08:29:42.081Z","claim_ids":[],"prev":"8593944afa55656b9d45ad8d916ed5d617031e25c1fe3ada88c1b1e3597d6376","hash":"9c1dec985f9cdfe7fef2f8e868a389e5580d1410c10ffff54c28c9754a013a6a","plain":"A human trial, and the one that cuts against the compound. The apparent advantage turned out to sit in the groups before treatment even started, and the investigators said outright that the improvement carried little clinical meaning."},{"url":"https://pubmed.ncbi.nlm.nih.gov/3792404/","title":"Efficacy of DSIP to normalize sleep in middle-aged and elderly chronic insomniacs — Schneider-Helmert D. Eur Neurol. 1986;25(6):448-53. PMID 3792404","quote":"The population of 18 chronic psychophysiological insomniacs was subdivided into two groups of middle-aged (29-59) and older (60-83) insomniacs. The whole sample of insomniacs showed normal sleep patterns at the end of the investigation.","_id":"w_yaqq0mom","_ts":"2026-08-04T08:29:42.373Z","id":"w_yaqq0mom","type":"source","accessed_at":"2026-08-04T08:29:42.373Z","claim_ids":[],"prev":"9c1dec985f9cdfe7fef2f8e868a389e5580d1410c10ffff54c28c9754a013a6a","hash":"3e9b35590a834653d25ba6cd294c7100316f40ee17496cd26cda906fda584308","plain":"Eighteen people with long-standing insomnia, split into a middle-aged and an older group, all sleeping normally by the end. That sounds strong and is the weakest design for proving why: no placebo arm, and insomnia scores improve on attention alone."},{"url":"https://pubmed.ncbi.nlm.nih.gov/6328354/","title":"Successful treatment of withdrawal symptoms with delta sleep-inducing peptide, a neuropeptide with potential agonistic activity on opiate receptors — Dick P, Grandjean ME, Tissot R. Neuropsychobiology. 1983;10(4):205-8. PMID 6328354","quote":"DSIP (25 nmol/kg) was injected intravenously as sole treatment to 67 patients presenting withdrawal symptoms (28 from ethyl alcohol, 39 from opiates). 27% of the patients were lost or unsuitable for evaluation. From the 49 evaluable patients, DSIP produced a beneficial effect in 48.","_id":"w_ee6vmdc4","_ts":"2026-08-04T08:29:42.929Z","id":"w_ee6vmdc4","type":"source","accessed_at":"2026-08-04T08:29:42.929Z","claim_ids":[],"prev":"3e9b35590a834653d25ba6cd294c7100316f40ee17496cd26cda906fda584308","hash":"1f5ef3e5c49b5d10583d9733b85e6241c50191b9111e40d6595e5078112da07a","plain":"Sixty-seven people in alcohol or opiate withdrawal, given it by vein as the only treatment. No control group, no blinding, a quarter of them dropped out of the count, and withdrawal fades by itself - which is exactly what this design cannot rule out."},{"url":"https://pubmed.ncbi.nlm.nih.gov/6548969/","title":"DSIP in the treatment of withdrawal syndromes from alcohol and opiates — Dick P, Costa C, Fayolle K, Grandjean ME, Khoshbeen A, Tissot R. Eur Neurol. 1984;23(5):364-71. PMID 6548969","quote":"DSIP was administered intravenously to 107 inpatients presenting with symptoms of alcohol (n = 47) or opiate (n = 60) withdrawal. The assessment of effect was based on the clinical evaluation by the physician and the nursing staff.","_id":"w_0vnryw2z","_ts":"2026-08-04T08:29:43.305Z","id":"w_0vnryw2z","type":"source","accessed_at":"2026-08-04T08:29:43.305Z","claim_ids":[],"prev":"1f5ef3e5c49b5d10583d9733b85e6241c50191b9111e40d6595e5078112da07a","hash":"d73d33f7bad4f3b71f5a084773853ee51de17cd1675a65238a701c66a9887f44","plain":"The larger follow-up, and the outcome measure is doctors and nurses forming an impression. With no placebo and no blinding it records that the treatment was given and the staff were satisfied, not that the peptide caused the change."},{"url":"https://pubmed.ncbi.nlm.nih.gov/9617990/","title":"Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trial — Backmund M, Meyer K, Rothenhaeusler HB, Soyka M. J Clin Psychopharmacol. 1998;18(3):257-8. PMID 9617990","quote":"Open clinical trial of DSIP in opioid detoxification; no placebo control and no blinding.","_id":"w_5aputa1e","_ts":"2026-08-04T08:29:43.911Z","id":"w_5aputa1e","type":"source","accessed_at":"2026-08-04T08:29:43.911Z","claim_ids":[],"prev":"d73d33f7bad4f3b71f5a084773853ee51de17cd1675a65238a701c66a9887f44","hash":"72320136167c0d2aff8c140dca1e82cc903909b5adc8ad8f523f5b436f0bae15","plain":"The most recent human study of this compound, and it was open-label - everyone knew what was being given and there was nothing to compare against. Detoxification improves over days regardless, and this design cannot separate the two."},{"url":"https://pubmed.ncbi.nlm.nih.gov/6379493/","title":"Development of an enzyme immunoassay for delta sleep-inducing peptide (DSIP) and its use in the determination of the metabolic clearance rate of DSIP administered to dogs — Kato N, Honda Y, Ebihara S, Naruse H, Takahashi Y. Neuroendocrinology. 1984;39(1):39-44. PMID 6379493","quote":"DSIP was found to have a rapid disappearance with a mean metabolic clearance rate of 30.7 +/- 2.5 ml/kg . min and a mean half-life of 4.0 +/- 0.7 min in the dogs. Additional measurement in a monkey and 3 rats revealed a rapid in vivo clearance of DSIP from plasma with a half-life of 2.9 and 2.0 +/- 0.54 min, respectively.","_id":"w_w4ku9pni","_ts":"2026-08-04T08:29:44.193Z","id":"w_w4ku9pni","type":"source","accessed_at":"2026-08-04T08:29:44.193Z","claim_ids":[],"prev":"72320136167c0d2aff8c140dca1e82cc903909b5adc8ad8f523f5b436f0bae15","hash":"9dcd63922be2550061d96fd27a1fb8699c62b6f51aa66eebdd935f5be350f545","plain":"Dogs, with a monkey and three rats alongside. The point is speed: it is cleared from blood within minutes, which puts a hard ceiling on what any single evening dose could still be doing later that night."},{"url":"https://pubmed.ncbi.nlm.nih.gov/3628078/","title":"Degradation and aggregation of delta sleep-inducing peptide (DSIP) and two analogs in plasma and serum — Graf MV, Saegesser B, Schoenenberger GA. Peptides. 1987;8(4):599-603. PMID 3628078","quote":"It was concluded that the rapid disappearance of injected DSIP in blood was due to degradation, whereas complex formation together with slower degradation resulted in longer persistence of apparently intact analogs.","_id":"w_nxo79twi","_ts":"2026-08-04T08:29:44.505Z","id":"w_nxo79twi","type":"source","accessed_at":"2026-08-04T08:29:44.505Z","claim_ids":[],"prev":"9dcd63922be2550061d96fd27a1fb8699c62b6f51aa66eebdd935f5be350f545","hash":"a3d2d0a91a0c327c4dac5d232f7cba69bc42ed13b5c2a12af6dea641d7c9c6c6","plain":"Explains the vanishing act - the peptide is chopped up in blood rather than merely filtered out, and modified versions last longer, which is why analogues exist. A laboratory measurement about survival, silent on whether any of it works."},{"url":"https://pubmed.ncbi.nlm.nih.gov/8475226/","title":"Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women — Giusti M, Carraro A, Porcella E, Valenti S, Nicora D, Sessarego P, Giordano G. Psychoneuroendocrinology. 1993;18(1):79-84. PMID 8475226","quote":"Serum GH and PRL levels were normal under basal conditions and no effects were noted after the infusion of DSIP. The GH and PRL circadian rhythm was not modified by DSIP administration.","_id":"w_zga2djoc","_ts":"2026-08-04T08:29:44.779Z","id":"w_zga2djoc","type":"source","accessed_at":"2026-08-04T08:29:44.779Z","claim_ids":[],"prev":"a3d2d0a91a0c327c4dac5d232f7cba69bc42ed13b5c2a12af6dea641d7c9c6c6","hash":"517d12460731be19e85f0f3fbd33e203b2e96637dc93e6bc271392c51073ec34","plain":"Healthy women, infused and tracked across a full day. It is a direct human test of the growth-hormone story attached to this peptide, aimed at exactly that claim, and it found nothing. Small, but human and specific."},{"url":"https://pubmed.ncbi.nlm.nih.gov/3550343/","title":"Delta sleep-inducing peptide (DSIP) stimulates LH release in steroid-primed ovariectomized rats — Sahu A, Kalra SP. Life Sci. 1987;40(12):1201-6. PMID 3550343","quote":"While intraventricular administration of DSIP (2 or 10 micrograms) failed to affect LH release in ovariectomized rats, in two separate experiments DSIP promptly stimulated LH release in ovariectomized estrogen, progesterone-primed rats. However, DSIP had no effect on either basal or LHRH-induced in vitro LH release from the hemipituitaries.","_id":"w_lq5x8aor","_ts":"2026-08-04T08:29:45.079Z","id":"w_lq5x8aor","type":"source","accessed_at":"2026-08-04T08:29:45.079Z","claim_ids":[],"prev":"517d12460731be19e85f0f3fbd33e203b2e96637dc93e6bc271392c51073ec34","hash":"a4ee8fca8f1685843ede1566f03278bf030f6a39f199c7da1ecf30506ee46cab","plain":"Rats with ovaries removed, where the hormone effect showed up only in animals first given oestrogen and progesterone, and not at all in isolated pituitary tissue. Whatever is happening is indirect and depends on the hormonal background."},{"url":"https://pubmed.ncbi.nlm.nih.gov/26470489/","title":"The influence of delta sleep-inducing peptide on functional state of rats hepatocytes in foot-shock stress — Belykh AE, Bobyntsev II, Kryukov AA, Dudka VT. Ross Fiziol Zh Im I M Sechenova. 2015;101(6):700-7. PMID 26470489","quote":"It was observed that 120 mcg/kg peptide normalized the elevation of malondialdehyde (MDA) level in the liver homogenate caused by acute foot-shock stress. Peptide in all doses provided the normalization of protein synthetic hepatocyte function.","_id":"w_cqubqjkn","_ts":"2026-08-04T08:29:45.402Z","id":"w_cqubqjkn","type":"source","accessed_at":"2026-08-04T08:29:45.402Z","claim_ids":[],"prev":"a4ee8fca8f1685843ede1566f03278bf030f6a39f199c7da1ecf30506ee46cab","hash":"2f3a12c6a27abafc5124255a46abed2fabf39f7ac56b712f77cf61f42d1f5aac","plain":"Rats given electric foot shocks, with liver chemistry as the readout. It supports a general stress-buffering story at a stated dose, not a sleep story, and the stress is an acute laboratory shock rather than anything resembling ordinary strain."},{"url":"https://pubmed.ncbi.nlm.nih.gov/15911358/","title":"Antiepileptic activity of delta sleep-inducing peptide and its analogue in metaphit-provoked seizures in rats — Stanojlovic OP, Zivanovic DP, Mirkovic SD, Mikhaleva II. Seizure. 2005;14(4):240-7. PMID 15911358","quote":"DSIP and DSIP-12 significantly increased in delta and theta frequency bands and decreased the incidence, mean seizure grade and duration of metaphit convulsions.","_id":"w_1pggv0x0","_ts":"2026-08-04T08:29:45.715Z","id":"w_1pggv0x0","type":"source","accessed_at":"2026-08-04T08:29:45.715Z","claim_ids":[],"prev":"2f3a12c6a27abafc5124255a46abed2fabf39f7ac56b712f77cf61f42d1f5aac","hash":"391fb10a7b25efff8c1a8e9b7f832c3fdb19202e0b62434db887ae25c1bec073","plain":"Seizures chemically provoked in rats, fewer and milder with the peptide and with a modified version of it. An anticonvulsant signal in one artificial model, never carried forward into human testing."},{"url":"https://pubmed.ncbi.nlm.nih.gov/6549349/","title":"Antagonism of the effect of delta sleep-inducing peptide by naloxone in the rat — Young AM, Key BJ. Neuropharmacology. 1984;23(11):1347-50. PMID 6549349","quote":"This sleep promoting effect was blocked by pre-treatment with the opiate antagonist naloxone at a dose level (0.1 mg/Kg s.c.) considered selective for mu-receptors.","_id":"w_xwm13uhv","_ts":"2026-08-04T08:29:46.056Z","id":"w_xwm13uhv","type":"source","accessed_at":"2026-08-04T08:29:46.056Z","claim_ids":[],"prev":"391fb10a7b25efff8c1a8e9b7f832c3fdb19202e0b62434db887ae25c1bec073","hash":"53904f6087c5cfc0278fb3fc98687fdd93eb7f1d2145c3565dc5c40d66ff006f","plain":"A small rat pharmacology result with a large implication: blocking opioid receptors abolished the sleep effect entirely. If the sedation runs through that system, this is not the clean unrelated sleep switch the name implies."},{"url":"https://pubmed.ncbi.nlm.nih.gov/6548967/","title":"Some pharmacological effects of delta-sleep-inducing peptide (DSIP) — Scherschlicht R, Aeppli L, Polc P, Haefely W. Eur Neurol. 1984;23(5):346-52. PMID 6548967","quote":"In cats, 25 micrograms x kg-1 i.v. and 100 micrograms x kg-1 s.c. preferentially augmented REM sleep. In most experimental situations, indications for bell-shaped dose-response curves of DSIP were found.","_id":"w_lklbxmce","_ts":"2026-08-04T08:29:46.381Z","id":"w_lklbxmce","type":"source","accessed_at":"2026-08-04T08:29:46.381Z","claim_ids":[],"prev":"53904f6087c5cfc0278fb3fc98687fdd93eb7f1d2145c3565dc5c40d66ff006f","hash":"d1fa7953fc1b69896f58119a39b94ee00f926abdd060763a5f02c2c29b4ccdc6","plain":"Cats, dosed two ways. What matters is the shape of the response rather than its size - a hump, not a slope. Past the peak a larger dose does less, so raising the amount when nothing happens works against you."},{"url":"https://pubmed.ncbi.nlm.nih.gov/6548966/","title":"Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP) — Schoenenberger GA. Eur Neurol. 1984;23(5):321-45. PMID 6548966","quote":"I.c.v., i.v. and s.c. administration yielded, in contrast to pharmaka, a parabolic dose-response curve with different effective optima. The half-life time for proteolytic split-off of tryptophan by brain slices and homogenates is 15 min.","_id":"w_6nqi6ir3","_ts":"2026-08-04T08:29:46.726Z","id":"w_6nqi6ir3","type":"source","accessed_at":"2026-08-04T08:29:46.726Z","claim_ids":[],"prev":"d1fa7953fc1b69896f58119a39b94ee00f926abdd060763a5f02c2c29b4ccdc6","hash":"bb4fa7fa8fc4a215e1aa24cc99cab659fef21fac03b268a3b256199dc1259f8e","plain":"The discovering laboratory's own review, conceding two awkward parts: no straight line from dose to effect, and brain tissue starts clipping the peptide apart within minutes. Written by the person who proposed it, so weigh the favourable passages accordingly."},{"url":"https://clinicaltrials.gov/api/v2/studies?query.term=%22delta+sleep-inducing+peptide%22&countTotal=true","title":"ClinicalTrials.gov API v2 query for \"delta sleep-inducing peptide\" and for emideltide, run 4 August 2026","quote":"totalCount: 0. Separate queries for the term \"emideltide\" and for DSIP as a registered intervention also returned totalCount 0 — no registered clinical trial of the compound exists in the registry.","_id":"w_z711kz2m","_ts":"2026-08-04T08:29:47.037Z","id":"w_z711kz2m","type":"source","accessed_at":"2026-08-04T08:29:47.037Z","claim_ids":[],"prev":"bb4fa7fa8fc4a215e1aa24cc99cab659fef21fac03b268a3b256199dc1259f8e","hash":"23f895d96bd970d46d8c07cb576030a54821ab3f755027e4cfef1029abee5e18","plain":"Three separate searches of the federal trial registry - the peptide's name, its drug name, and it as a listed intervention - all came back empty. There is no registered human trial anywhere for anyone to be waiting on."},{"url":"https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks","title":"FDA — Certain Bulk Drug Substances for Use in Compounding That May Present Significant Safety Risks; table: Bulk drug substances nominated but withdrawn","quote":"Emideltide (DSIP): Compounded drugs containing emideltide may pose risk for immunogenicity for certain routes of administration and may have complexities with regard to peptide-related impurities and API characterization. FDA has not identified safety-related information regarding emideltide for the proposed route of administration. Therefore, the agency lacks sufficient information to know whether the drug would cause harm if administered to humans.","_id":"w_ww3yt0x9","_ts":"2026-08-04T08:29:47.404Z","id":"w_ww3yt0x9","type":"source","accessed_at":"2026-08-04T08:29:47.404Z","claim_ids":[],"prev":"23f895d96bd970d46d8c07cb576030a54821ab3f755027e4cfef1029abee5e18","hash":"6960d5a315ee31d0a49e1a83563d435057bbed2622a7a31da98cb35019f3356d","plain":"The agency's own table of nominations that were pulled. Withdrawn is not refused: it leaves the compound neither approved nor formally banned, and the stated worries are impurities, characterisation and immune reaction rather than a known injury."},{"url":"https://pubmed.ncbi.nlm.nih.gov/30692228/","title":"The Pain of Sleep Loss: A Brain Characterization in Humans — Krause AJ, Prather AA, Wager TD, Lindquist MA, Walker MP. J Neurosci. 2019;39(12):2291-2300. PMID 30692228","quote":"Sleep deprivation expands the temperature range for classifying a stimulus as painful, specifically through a lowering of pain thresholds. Even modest nightly changes in sleep quality (increases and decreases) within an individual determine consequential day-to-day changes in experienced pain.","_id":"w_9shvk46m","_ts":"2026-08-04T08:29:48.420Z","id":"w_9shvk46m","type":"source","accessed_at":"2026-08-04T08:29:48.420Z","claim_ids":[],"prev":"6960d5a315ee31d0a49e1a83563d435057bbed2622a7a31da98cb35019f3356d","hash":"5b1e90d670fa39297f355c4c9cd530ad9db5abfd465ea00788c7f5a5dd691bb8","plain":"Nothing to do with the peptide. It is on the page because it pins down what people are actually chasing - lose sleep and the temperature at which heat starts registering as pain drops, and it tracks night to night within the same person."},{"url":"https://pubmed.ncbi.nlm.nih.gov/26194577/","title":"Experimental Sleep Restriction Facilitates Pain and Electrically Induced Cortical Responses — Matre D, Hu L, Viken LA, et al. Sleep. 2015;38(10):1607-17. PMID 26194577","quote":"Pain testing was performed after 2 nights of 50% sleep restriction and after 2 nights with habitual sleep. Pressure pain threshold of the trapezius muscle region also decreased after SR (P = 0.017).","_id":"w_2zo637na","_ts":"2026-08-04T08:29:48.967Z","id":"w_2zo637na","type":"source","accessed_at":"2026-08-04T08:29:48.967Z","claim_ids":[],"prev":"5b1e90d670fa39297f355c4c9cd530ad9db5abfd465ea00788c7f5a5dd691bb8","hash":"9d284d51955418a7378631bf35f91cfd1282e8a253e06abbaeb1d32442c5b89f","plain":"Volunteers cut to half a night's sleep, twice over. Pressure began hurting sooner afterwards. Because sleep was the thing manipulated, the direction is causal - but two lab nights are not a chronic sleep problem."},{"url":"https://pubmed.ncbi.nlm.nih.gov/24290442/","title":"The association of sleep and pain: an update and a path forward — Finan PH, Goodin BR, Smith MT. J Pain. 2013;14(12):1539-52. PMID 24290442","quote":"A key trend emerging from population-based longitudinal studies is that sleep impairments reliably predict new incidents and exacerbations of chronic pain. Sleep impairments are a stronger, more reliable predictor of pain than pain is of sleep impairments.","_id":"w_47nktqzd","_ts":"2026-08-04T08:29:49.339Z","id":"w_47nktqzd","type":"source","accessed_at":"2026-08-04T08:29:49.339Z","claim_ids":[],"prev":"9d284d51955418a7378631bf35f91cfd1282e8a253e06abbaeb1d32442c5b89f","hash":"a12c561a8e227b930d6310ff4cb6066103b5864589806303b35f819f57316aa1","plain":"A review of long-term population studies that settles which way the arrow points: poor sleep predicts new and worsening pain more dependably than pain predicts poor sleep. Background for the page, with no bearing on any peptide."},{"url":"https://pubmed.ncbi.nlm.nih.gov/30107617/","title":"Sleep fragmentation delays wound healing in a mouse model of type 2 diabetes — McLain JM, Alami WH, Glovak ZT, et al. Sleep. 2018;41(11):zsy156. PMID 30107617","quote":"Days to achieve 50 per cent wound healing were 13.3 +/- 0.4 with sleep fragmentation compared with 10.3 +/- 0.7 without sleep fragmentation.","_id":"w_ikb821wn","_ts":"2026-08-04T08:29:49.889Z","id":"w_ikb821wn","type":"source","accessed_at":"2026-08-04T08:29:49.889Z","claim_ids":[],"prev":"a12c561a8e227b930d6310ff4cb6066103b5864589806303b35f819f57316aa1","hash":"abaffbe2c125d676a3cce67ab31280578af0d235a217b3dbe7ae803169f4f646","plain":"Diabetic mice whose sleep was deliberately broken up took about three days longer to get a wound halfway closed. The animal version of the sleep-and-repair argument - a fair reason to care about sleep, and no evidence about a compound."},{"url":"https://pubmed.ncbi.nlm.nih.gov/26054060/","title":"Cognitive Behavioral Therapy for Chronic Insomnia: A Systematic Review and Meta-analysis — Trauer JM, Qian MY, Doyle JS, Rajaratnam SM, Cunnington D. Ann Intern Med. 2015;163(3):191-204. PMID 26054060","quote":"At the posttreatment time point, SOL improved by 19.03 (95% CI, 14.12 to 23.93) minutes, WASO improved by 26.00 (CI, 15.48 to 36.52) minutes, and SE% improved by 9.91% (CI, 8.09% to 11.73%). No adverse outcomes were reported.","_id":"w_363tewrt","_ts":"2026-08-04T08:29:50.259Z","id":"w_363tewrt","type":"source","accessed_at":"2026-08-04T08:29:50.259Z","claim_ids":[],"prev":"abaffbe2c125d676a3cce67ab31280578af0d235a217b3dbe7ae803169f4f646","hash":"7b610eaf538f1755c4589d10acda54dffd2d6a97b237d32ad2c182c46edabd3c","plain":"The comparator with the strongest evidence behind it, and it is not a drug at all. Pooled across trials of a talk-based treatment for long-term insomnia, every standard sleep measure improved with no harms reported. That is the bar to clear."},{"url":"https://pubmed.ncbi.nlm.nih.gov/35843245/","title":"Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis — De Crescenzo F, et al. Lancet. 2022;400(10347):170-184. PMID 35843245","quote":"We included 170 trials (36 interventions and 47,950 participants). In terms of acute treatment, benzodiazepines, doxylamine, eszopiclone, lemborexant, seltorexant, zolpidem, and zopiclone were more efficacious than placebo (SMD range 0.36-0.83). Melatonin, ramelteon, and non-licensed drugs did not show overall material benefits.","_id":"w_ry66bqki","_ts":"2026-08-04T08:29:50.584Z","id":"w_ry66bqki","type":"source","accessed_at":"2026-08-04T08:29:50.584Z","claim_ids":[],"prev":"7b610eaf538f1755c4589d10acda54dffd2d6a97b237d32ad2c182c46edabd3c","hash":"0181f01578ae4c9bf21bfe38ff3aec60c9abbf0f5b6cc8b76eac5b4ccfe680f3","plain":"One hundred and seventy trials and close to fifty thousand people, ranking sleep drugs against placebo and each other. It sits here as the measuring stick: this peptide has never been entered into a comparison of that kind and could not be placed on it."},{"url":"https://pubmed.ncbi.nlm.nih.gov/16539679/","title":"Delta sleep-inducing peptide (DSIP): a still unresolved riddle — Kovalzon VM, Strekalova TV. J Neurochem. 2006;97(2):303-9. PMID 16539679","quote":"The link between DSIP and sleep has never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor. Thus the hypothesis regarding DSIP as a sleep factor is extremely poorly documented and still weak.","_id":"w_l0pqsfj3","_ts":"2026-08-04T08:29:50.972Z","id":"w_l0pqsfj3","type":"source","accessed_at":"2026-08-04T08:29:50.972Z","claim_ids":[],"prev":"0181f01578ae4c9bf21bfe38ff3aec60c9abbf0f5b6cc8b76eac5b4ccfe680f3","hash":"acca4ba3bfdbf18da3b8edb5502ab8cd65915cf86223eeb943676579fa2aab15","plain":"The verdict from inside the sleep field, three decades on. No gene, no protein and no receptor were ever pinned down, and the authors call the sleep hypothesis poorly documented and weak - a judgement from people who worked on it."},{"url":"https://pubmed.ncbi.nlm.nih.gov/41490200/","title":"Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions — Rahman OF, Lee SJ, Seeds WA. J Am Acad Orthop Surg Glob Res Rev. 2026;10(1):e25.00236. PMID 41490200","quote":"Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pinealon target circadian and mitochondrial regulators. Although preclinical studies are promising, there is a current lack of clinical trials.","_id":"w_d2edzzyj","_ts":"2026-08-04T08:29:51.440Z","id":"w_d2edzzyj","type":"source","accessed_at":"2026-08-04T08:29:51.440Z","claim_ids":[],"prev":"acca4ba3bfdbf18da3b8edb5502ab8cd65915cf86223eeb943676579fa2aab15","hash":"aaa6691e29fc1a54100ccf63cbdba078dc34d3fc01940eb44ad3355cc39d35d5","plain":"A 2026 clinical journal listing it among recovery peptides, which is largely how it reaches people now. The review flags its own gap in the same breath: animal work only, no clinical trials. Opinion and summary, not new evidence."},{"url":"https://pubmed.ncbi.nlm.nih.gov/3368469/","title":"Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat — Iyer KS, Marks GA, Kastin AJ, McCann SM. Proc Natl Acad Sci USA. 1988;85(10):3653-6. PMID 3368469","quote":"Male rats were deprived of sleep for 4 hr by placing them on a slowly rotating wheel. These increases were blocked by microinjection into the third cerebral ventricle of highly specific antiserum to DSIP.","_id":"w_7lo702h8","_ts":"2026-08-04T08:29:52.642Z","id":"w_7lo702h8","type":"source","accessed_at":"2026-08-04T08:29:52.642Z","claim_ids":[],"prev":"aaa6691e29fc1a54100ccf63cbdba078dc34d3fc01940eb44ad3355cc39d35d5","hash":"3133bbd612aca74c45c02f5254eef74a2a712c38c7599d96a305828bdd1bb52c","plain":"Rats kept awake on a slowly turning wheel. Blocking the animals' own peptide with an antibody injected into the brain removed the rebound, the best evidence that the body's own supply matters - a different question from whether injecting more helps."},{"url":"https://pubmed.ncbi.nlm.nih.gov/15636354/","title":"Effects of sleep deprivation, nicotine, and selenium on wound healing in rats — Gumustekin K, Seven B, Karabulut N, et al. Int J Neurosci. 2004;114(11):1433-42. PMID 15636354","quote":"The number of fibroblasts and capillary vessels were higher in control and Se groups than in sleep deprivation and nicotine groups. The results suggest that sleep deprivation and nicotine may delay wound healing.","_id":"w_7fiszq9g","_ts":"2026-08-04T08:29:53.108Z","id":"w_7fiszq9g","type":"source","accessed_at":"2026-08-04T08:29:53.108Z","claim_ids":[],"prev":"3133bbd612aca74c45c02f5254eef74a2a712c38c7599d96a305828bdd1bb52c","hash":"afb7f9538253b4e903e6689ed6effbbfa2663b97321920fb35013447fc337f89","plain":"Sleep-deprived rats healed with fewer repair cells and fewer new blood vessels than rats allowed to sleep. Supporting background on why sleep matters to recovery; nicotine was tested in the same study, and no peptide was involved."}],"reviews":[],"extra":{"proven_work":{"work_id":"PW-0020","claim":"This object is a documentation work product on DSIP (delta sleep-inducing peptide), whose stated conclusion is that the peptide is named for the one effect its evidence supports least. What was asked: make it inspectable as an object. What was done in this session: five sibling work objects were bound into the body and the machine view. What was considered and rejected: rewriting the prose. What is guaranteed: 102 claims are addressable and tiered, 132 sources are registered, every write carries a receipt. What is open: a small number of unbound claims, and prose formation payloads not bound to this object.","claim_reconstructed":true,"claim_authorship":"This claim was written after the work it describes, by the session that atomised the claims and bound the sibling relationships. Under spec 1.1.0 rule f it is declared reconstructed.","spec":"https://miscsubjects.com/a/proven-work (PROVEN_WORK_SPEC 1.1.0)","article_scope":"article:dsip","requirements":[{"id":"claims_atomised","status":"PASS","what":"102 claims are stored as addressable units on this object, each carrying an id, a section, and an evidence tier. Tier distribution: anecdotal 72, human 9, mechanistic 2, preclinical 4, speculative 14, system 1. They generate the DIV/voxel structure, so every sentence of argument has its own hash and challenge surface. Tiers outside the five-tier evidence law (human/preclinical/anecdotal/mechanistic/speculative): system — inherited from earlier writes, declared not hidden.","evidence":["inv_3l3aefxzcz"]},{"id":"claims_bound_or_gap_named","status":"GAP","what":"100 of 102 claims carry source ids and 0 more carry an explicit source_status sentence naming why no source is attachable. 2 claims carry neither and are unsupported until bound. 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PARTIAL means at least one requirement is a named gap, printed on the object."}},"has_traversal":false,"register":"essay","status":"published","revisions":67,"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T08:33:21.447Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"DSIP: Natural Deep Sleep","register":"source_ledger","body":"## Evidence-Graded Overview\n\nDSIP (Delta Sleep-Inducing Peptide) is a nonapeptide first isolated from rabbit cerebral venous blood. Preclinical studies in multiple species have examined its association with slow-wave sleep.\n\n## Preclinical Data (Animal and Cell Studies)\n\nRat studies link endogenous DSIP to slow-wave sleep (SWS) induction and sleep-related growth hormone release. Sleep deprivation in rats increased SWS and plasma GH; these increases were blocked by DSIP antiserum (preclinical tier).\n\nDSIP administration has promoted sleep parameters in rabbits, rats, cats, and mice (preclinical tier).\n\n## Human Trial Data\n\nSmall double-blind and open studies from the 1980s reported objective sleep improvements in chronic insomniacs. One 1992 study (n=16) found higher sleep efficiency and shorter latency versus placebo, with no subjective quality change (human tier).\n\nA 1981 study (n=6) noted longer sleep duration, fewer interruptions, and slightly more REM without daytime sedation (human tier).\n\nResults across limited human studies have been variable; no large-scale modern randomized controlled trials exist (human tier).\n\n## Mechanistic and Speculative Notes\n\nDSIP is described as promoting sleep pressure rather than acting as a sedative (mechanistic tier). No human data support suppression of natural sleep architecture or comparison to pharmaceutical hypnotics.\n\n## Anecdotal/User Reports\n\nSparse user reports mention subjective increases in tracked deep sleep stages without next-day effects (anecdotal tier).\n\n## Limitations\n\nAll human data derive from small, dated trials with mixed outcomes. No large human datasets available.","claims":[{"id":"c1","text":"Rat studies show DSIP antiserum blocks sleep-deprivation-induced increases in SWS and GH release.","section":"Preclinical Data","tier":"preclinical","source_ids":["s1"],"source_status":"sourced","why_material":"Separates rat data from human evidence.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"1992 double-blind study (n=16 chronic insomniacs) reported higher objective sleep efficiency and shorter latency with DSIP vs placebo, but no subjective change.","section":"Human Trial Data","tier":"human","source_ids":["s2"],"source_status":"sourced","why_material":"Primary human trial result, small sample noted.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"1981 study (n=6 insomniacs) found longer sleep duration, fewer interruptions, and more REM with DSIP, without daytime sedation.","section":"Human Trial Data","tier":"human","source_ids":["s3"],"source_status":"sourced","why_material":"Additional small human trial separating from preclinical.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c4","text":"DSIP promotes sleep in rabbits, rats, cats, and mice.","section":"Preclinical Data","tier":"preclinical","source_ids":["s4"],"source_status":"sourced","why_material":"Animal species-specific data.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c5","text":"Limited user reports note subjective deep sleep increases on tracking without hangover effects.","section":"Anecdotal/User Reports","tier":"anecdotal","source_ids":["s5"],"source_status":"sourced","why_material":"Distinguishes user reports from trials.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"pubmed","url":"https://www.pnas.org/doi/10.1073/pnas.85.10.3653","title":"Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat","quote":"These increases were blocked by microinjection into the third cerebral ventricle of highly specific antiserum to DSIP.","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/1299794/","title":"Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study","quote":"The results for objective sleep quality indicated higher sleep efficiency and shorter sleep latency with DSIP as compared to placebo.","link_status":"ok","quote_status":"verified"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/7028502/","title":"The influence of synthetic DSIP on disturbed human sleep","quote":"longer sleep duration and a higher quality of sleep with fewer interruptions; slightly more REM-sleep, but no day-time sedation","link_status":"ok","quote_status":"verified"},{"id":"s4","type":"review","url":"https://journals.lww.com/ejanaesthesiology/fulltext/2001/07000/delta_sleep_inducing_peptide.1.aspx","title":"Delta sleep-inducing peptide","quote":"DSIP promotes sleep and this has been demonstrated in rabbits, mice, rats, cats and human beings","link_status":"ok","quote_status":"verified"},{"id":"s5","type":"instagram","url":"https://www.instagram.com/reel/DURfvtYj6Qz/","title":"DSIP Peptide user discussion","quote":"my deep sleep is soooo high. It doesn't make you tired or ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"44e6b89c77f3c5c87735be992cb81463a2e4445f4f9230f3c3d07f49ec815740"},{"seq":1,"id":"k2","ts":"2026-06-29T09:51:06.624Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16539679/","title":"Delta sleep-inducing peptide (DSIP): a still unresolved riddle","quote":"Delta sleep-inducing peptide (DSIP) was isolated from rabbit cerebral venous blood by Schoenenberger-Monnier group from Basel in 1977 and initially regarded as a candidate sleep-promoting factor.","link_status":"ok","quote_status":"verified"},{"id":"s7","type":"review","url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1439536/full","title":"Pichia pastoris secreted peptides crossing the blood-brain barrier","quote":"Delta sleep-inducing peptide (DSIP) is composed of 9 amino acids and has been implicated in the regulation of sleep, modulation of stress (Morgan, 2023), and exhibits a wide range of physiological and pharmacological effects.","link_status":"ok","quote_status":"unverified"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/34500605/","title":"Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke","quote":"Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.","link_status":"ok","quote_status":"verified"},{"id":"s9","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1pcdd5q/dsip_review_the_sleep_peptide_that_gave_me/","title":"DSIP Review: The Sleep Peptide That Gave Me Inception Level Lucid Dreams","quote":"it’s like Inception in a bottle. 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DSIP shots made my sleep a lot worse","link_status":"ok","quote_status":"unverified"},{"id":"s96","type":"reddit","url":"https://www.reddit.com/r/sleep/comments/1l1zbhz/actual_peptides_meds_that_will_give_you_deep_sleep/","title":"Actual peptides / meds that will give you deep sleep?","quote":"I take it and it does not affect sleep time or deep sleep but no matter how little sleep I get, there is always REM and that was not the case pre-DSIP.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"90f17e31c4fbf112cb8e2a9935cbd872bdff1de569ed74cf1eacb1f9378df9a5","hash":"ff0f176634d9ea890c2aa4ff42bda408f9d0bc07c9d2521e8155b0a89c5ea70b"},{"seq":30,"id":"k31","ts":"2026-06-29T17:38:24.663Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s97","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1nnfj2w/dsip_intranasalsubq_complete_opiate_withdrawal/","title":"DSIP Intranasal/Sub-Q Complete Opiate Withdrawal Relief","quote":"Current dosage is about 1mg at a time sub-q or 50mcg per nostril. ... 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I felt no effects at all ...","link_status":"ok","quote_status":"unverified"},{"id":"s101","type":"reddit","url":"https://www.reddit.com/r/sleephackers/comments/1ag716c/any_personal_experience_with_dsip_delta/","title":"any personal experience with DSIP (Delta Sleep-Inducing Peptide)?","quote":"I am sleeping through the night MUCH better after a few doses of DSIP.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"fa5023ad7c95de59256ae9fc9f8d4a0705b5d6ebe9ead449a3ba828241f2ecc8","hash":"5a96a62ecdb83e59a7e187a9ae350688298b00ab5357c0727a0e8e1659966361"},{"seq":33,"id":"k34","ts":"2026-06-29T17:40:18.712Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s102","type":"x","url":"https://x.com/gr8tful88/status/2071404994192974208","title":"X post listing peptides including DSIP","quote":"Sleep: DSIP, Epitalon.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"5a96a62ecdb83e59a7e187a9ae350688298b00ab5357c0727a0e8e1659966361","hash":"995f74d6aff3aa5fa5f51f2f5dc4919e4b6e11665f85fa0edd9dbb50ca95b49c"},{"seq":34,"id":"k35","ts":"2026-06-29T20:41:05.566Z","model":"fill-slots","role":"claim_post","action":"claim","payload":{"claim_id":"c115","tier":"runtime","text":"DSIP: Natural Deep Sleep is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T20:41:05.566Z","model":"fill-slots","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"995f74d6aff3aa5fa5f51f2f5dc4919e4b6e11665f85fa0edd9dbb50ca95b49c","hash":"49c99b37a657d0ce8924bc262670f6d6663beb4326a6627e49a9fb11a70af86c"}],"provenance":[{"ts":"2026-06-29T08:33:21.447Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):\nBPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).\nTB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.\nARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.\nSemax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.\nSelank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).\nPT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).\nDSIP — Delta Sleep Inducing Peptide; natural deep sleep without Ambien-class hangover.\nKPV — Gut-specific anti-inflammatory; calms gut lining without systemic immune suppression.\nGHK-Cu — Tissue remodeling; builds collagen scaffolding. Production drops 60-80% with age.\nThymosin Alpha-1 — Immune modulation; supports immune function without suppressing it.\n\nWrite a data-first, evidence-graded article: DSIP: Natural Deep Sleep\n\nGeneral evidence-graded intro for DSIP: Natural Deep Sleep. Data-first peptide definition article.\n\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate rat studies from human trials from user reports. No medical claims or treatment promises. Use repair-vs-suppression framing where relevant. register: source_ledger.","response":"{\n  \"slug\": \"dsip-natural-deep-sleep\",\n  \"title\": \"DSIP: Natural Deep Sleep\",\n  \"body\": \"## Evidence-Graded Overview\\n\\nDSIP (Delta Sleep-Inducing Peptide) is a nonapeptide first isolated from rabbit cerebral venous blood. Preclinical studies in multiple species have examined its association with slow-wave sleep.\\n\\n## Preclinical Data (Animal and Cell Studies)\\n\\nRat studies link endogenous DSIP to slow-wave sleep (SWS) induction and sleep-related growth hormone release. Sleep deprivation in rats increased SWS and plasma GH; these increases were blocked by DSIP antiserum (preclinical tier).\\n\\nDSIP administration has promoted sleep parameters in rabbits, rats, cats, and mice (preclinical tier).\\n\\n## Human Trial Data\\n\\nSmall double-blind and open studies from the 1980s reported objective sleep improvements in chronic insomniacs. One 1992 study (n=16) found higher sleep efficiency and shorter latency versus placebo, with no subjective quality change (human tier).\\n\\nA 1981 study (n=6) noted longer sleep duration, fewer interruptions, and slightly more REM without daytime sedation (human tier).\\n\\nResults across limited human studies have been variable; no large-scale modern randomized controlled trials exist (human tier).\\n\\n## Mechanistic and Speculative Notes\\n\\nDSIP is described as promoting sleep pressure rather than acting as a sedative (mechanistic tier). No human data support suppression of natural sleep architecture or comparison to pharmaceutical hypnotics.\\n\\n## Anecdotal/User Reports\\n\\nSparse user reports mention subjective increases in tracked deep sleep stages without next-day effects (anecdotal tier).\\n\\n## Limitations\\n\\nAll human data derive from small, dated trials with mixed outcomes. No large human datasets available.\",\n  \"register\": \"source_ledger\",\n  \"claims\": [\n    {\n      \"id\": \"c1\",\n      \"text\": \"Rat studies show DSIP antiserum blocks sleep-deprivation-induced increases in SWS and GH release.\",\n      \"section\": \"Preclinical Data\",\n      \"t","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"ea5856ace2c1ca5336565a03e4ca8a6311efc7692d75dde7ca2b47c6eec691f2"},{"ts":"2026-06-29T09:51:06.624Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"7 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ea5856ace2c1ca5336565a03e4ca8a6311efc7692d75dde7ca2b47c6eec691f2","hash":"40bd9733bf3f57e3057d80cf8ccd421cb77d0c3f320a3221a9d4cb1bd6e3039d"},{"ts":"2026-06-29T09:51:33.818Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"40bd9733bf3f57e3057d80cf8ccd421cb77d0c3f320a3221a9d4cb1bd6e3039d","hash":"3f000c9855f027099569b522f23d86cce7acb8c5efa5a714a0bbfcf01b590ad3"},{"ts":"2026-06-29T09:51:58.857Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"3f000c9855f027099569b522f23d86cce7acb8c5efa5a714a0bbfcf01b590ad3","hash":"b8478a406e1aa8e32f73ac1bb602e0b570532dc7f6fb6cf4679d1663b14c5fcf"},{"ts":"2026-06-29T09:52:13.716Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"8 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"b8478a406e1aa8e32f73ac1bb602e0b570532dc7f6fb6cf4679d1663b14c5fcf","hash":"811c77cfa8568247656cb2b274b61696036c79ba545703869bd8d1959f63fdac"},{"ts":"2026-06-29T09:53:05.250Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"811c77cfa8568247656cb2b274b61696036c79ba545703869bd8d1959f63fdac","hash":"022e0c80fdca1dfaab81130cc71296a7121c170c0ab68996370e0fd182a3ff27"},{"ts":"2026-06-29T09:53:21.017Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"7 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"022e0c80fdca1dfaab81130cc71296a7121c170c0ab68996370e0fd182a3ff27","hash":"23279fd66ad896ad3c1783dd9909461a2d03661e45eab6e9897dd76a02ff3196"},{"ts":"2026-06-29T09:53:40.459Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"23279fd66ad896ad3c1783dd9909461a2d03661e45eab6e9897dd76a02ff3196","hash":"ba726600569f3d886bd5c3a4724517db1a9dcb334c75985a2d09c8ece6549d27"},{"ts":"2026-06-29T09:53:54.841Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ba726600569f3d886bd5c3a4724517db1a9dcb334c75985a2d09c8ece6549d27","hash":"ebdce6594cf490cab793843756853bd0b9bf807eea587fd5fcc1fe1fdf2ff1da"},{"ts":"2026-06-29T09:55:05.574Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ebdce6594cf490cab793843756853bd0b9bf807eea587fd5fcc1fe1fdf2ff1da","hash":"6db596db245aed75140c4222a3329e8d690fb481326f83255899a5abac655859"},{"ts":"2026-06-29T09:55:25.044Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"6db596db245aed75140c4222a3329e8d690fb481326f83255899a5abac655859","hash":"3d0e2349bd1dbc9cb6c23f890352f769cbf93446ad2396ccada27ec5870ebef2"},{"ts":"2026-06-29T09:55:40.508Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"3d0e2349bd1dbc9cb6c23f890352f769cbf93446ad2396ccada27ec5870ebef2","hash":"02fbe76aeaf6a4adf77c85c20a02aaddc3e8feeee78bcd0851257f221bb7d698"},{"ts":"2026-06-29T12:45:19.402Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[\"5 claims missing posted_by\",\"56 orphan sources (no claim link)\",\"missing constitution slots: what_it_is, who_claims_what, what_is_known, what_is_unknown, limitations, disclaimer\"],\"after\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: what_it_is, who_claims_what, what_is_known, what_is_unknown, limitations, disclaimer\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"02fbe76aeaf6a4adf77c85c20a02aaddc3e8feeee78bcd0851257f221bb7d698","hash":"39370fb301a9764b88fa48ebcc75bdba2e54f324713401196292aed2d972aabe"},{"ts":"2026-06-29T12:45:20.133Z","model":"system/audit-repair","action":"claim","prompt":"","input":"dsip c6","response":"DSIP: Natural Deep Sleep is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"39370fb301a9764b88fa48ebcc75bdba2e54f324713401196292aed2d972aabe","hash":"c00a45a9d0d4d80ff10a0da41f3ab68fb3d6e33a5ad9cf84a7238a017b251714"},{"ts":"2026-06-29T12:45:20.302Z","model":"system/audit-repair","action":"claim","prompt":"","input":"dsip c7","response":"Per this ledger on DSIP: Natural Deep Sleep: 26 scientific and 29 anecdotal sources are catalogued; 3 preclinical claim(s) summarize animal/cell literature in-catalogue.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"c00a45a9d0d4d80ff10a0da41f3ab68fb3d6e33a5ad9cf84a7238a017b251714","hash":"0c999e730f8e0eb3a13521ee0e6f59f25af88a28682edd4d19a4c14df5c3c214"},{"ts":"2026-06-29T12:45:20.395Z","model":"system/audit-repair","action":"claim","prompt":"","input":"dsip c8","response":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","tokens_in":0,"tokens_out":0,"cost":0,"prev":"0c999e730f8e0eb3a13521ee0e6f59f25af88a28682edd4d19a4c14df5c3c214","hash":"4219ec4b3b5d1374614f374c8b2a4e80be69ba7e8c3e507dac66c87597bdf6c7"},{"ts":"2026-06-29T12:45:20.451Z","model":"system/audit-repair","action":"claim","prompt":"","input":"dsip c9","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4219ec4b3b5d1374614f374c8b2a4e80be69ba7e8c3e507dac66c87597bdf6c7","hash":"fb321aea724dc8728403068d87cde8eb32ff7b378c98c706b2278f68c2e48c38"},{"ts":"2026-06-29T12:45:20.670Z","model":"system/audit-repair","action":"claim","prompt":"","input":"dsip c10","response":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"fb321aea724dc8728403068d87cde8eb32ff7b378c98c706b2278f68c2e48c38","hash":"6c846a8f6c3b7deba7114d978beb3e7ffd3ecbedea906c4fa0c94cc1a69d50d6"},{"ts":"2026-06-29T12:45:21.459Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"],\"after\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"6c846a8f6c3b7deba7114d978beb3e7ffd3ecbedea906c4fa0c94cc1a69d50d6","hash":"76758eb65a3fb5c5639337c42d0054d7adc53ec6d629895073855c27d06587fc"},{"ts":"2026-06-29T12:45:52.530Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"],\"after\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"76758eb65a3fb5c5639337c42d0054d7adc53ec6d629895073855c27d06587fc","hash":"5b542f74588e3e745f867caba18b14bd93ff01f234b96a0be13e22ef7104c7dd"},{"ts":"2026-06-29T12:45:53.717Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"],\"after\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"5b542f74588e3e745f867caba18b14bd93ff01f234b96a0be13e22ef7104c7dd","hash":"896ce2ba11a98ab6c52a404714a54544abde021a21651ce150dda2a623f7c471"},{"ts":"2026-06-29T12:50:35.212Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":56,\"before\":[\"56 orphan sources (no claim link)\",\"missing constitution slots: who_claims_what\"],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"896ce2ba11a98ab6c52a404714a54544abde021a21651ce150dda2a623f7c471","hash":"1118a08e57d05b4c20c3c802382d34d333e7f9fa822383157ed3abf7fcdab2f7"},{"ts":"2026-06-29T12:50:37.646Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"1118a08e57d05b4c20c3c802382d34d333e7f9fa822383157ed3abf7fcdab2f7","hash":"77d290b347e64332cd5017196cdfebc873811c6fc224c24ad73322d916f29ee5"},{"ts":"2026-06-29T13:22:44.519Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"77d290b347e64332cd5017196cdfebc873811c6fc224c24ad73322d916f29ee5","hash":"98c6e4244dcb7d64727aaa77f94b9a71861b85bfe4fedc64c6369660de6eb595"},{"ts":"2026-06-29T13:22:45.815Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"98c6e4244dcb7d64727aaa77f94b9a71861b85bfe4fedc64c6369660de6eb595","hash":"9e50dba78853a0fe770b12c51fa729572f8a5ec86199f7ea01a6ded7170c7b77"},{"ts":"2026-06-29T13:44:44.428Z","model":"kimi/moonshot-v1-8k","action":"collaborate","prompt":"","input":"dsip","response":"I am adding explicit claims about what is unknown and who claims what from anecdotes, as these are gaps in the current ledger. I am not Grok because I am following the instructions to add claims that are tier-honest and based on the existing topology without inventing new URLs or sources.","tokens_in":3085,"tokens_out":431,"cost":0,"prev":"9e50dba78853a0fe770b12c51fa729572f8a5ec86199f7ea01a6ded7170c7b77","hash":"175dfe1a115055f4142b1f1cde07d9e68578948c04cbcb2e9127624eea868fc6"},{"ts":"2026-06-29T13:54:00.610Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"175dfe1a115055f4142b1f1cde07d9e68578948c04cbcb2e9127624eea868fc6","hash":"bb0fc5b33be7e75ccb262867aee46e06405ca21604b5a9416b123d6b25190077"},{"ts":"2026-06-29T13:54:01.791Z","model":"system/audit-repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"bb0fc5b33be7e75ccb262867aee46e06405ca21604b5a9416b123d6b25190077","hash":"2f7b4a7920ce87ebde652792c0c3e5c626338d0e9bf53115417d6340a574ca0b"},{"ts":"2026-06-29T15:35:28.735Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"2f7b4a7920ce87ebde652792c0c3e5c626338d0e9bf53115417d6340a574ca0b","hash":"e7ccc1c26ade5718ae9f6354e3a3a28f79263520b4fa6bead5a684d38f6c3f8c"},{"ts":"2026-06-29T15:35:52.935Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"e7ccc1c26ade5718ae9f6354e3a3a28f79263520b4fa6bead5a684d38f6c3f8c","hash":"26bc2180d6c3d85a7e968fb49816ebdc851fec517eb2da8c83694364285560f1"},{"ts":"2026-06-29T15:36:16.275Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"1 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"26bc2180d6c3d85a7e968fb49816ebdc851fec517eb2da8c83694364285560f1","hash":"89e68620b109738b24ff3063862d90e3a13b601c44b1ab9cbd60a8be303735aa"},{"ts":"2026-06-29T15:36:44.758Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"89e68620b109738b24ff3063862d90e3a13b601c44b1ab9cbd60a8be303735aa","hash":"bbbb5413c1bcc1f6238751e257f14e5b9359257c15edbab1dc85de3015fa5a88"},{"ts":"2026-06-29T15:37:37.876Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"bbbb5413c1bcc1f6238751e257f14e5b9359257c15edbab1dc85de3015fa5a88","hash":"23adf3a3d47b4a571343124b654776960e3ea56a254ef8f61770711161413c0c"},{"ts":"2026-06-29T15:38:03.510Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"3 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"23adf3a3d47b4a571343124b654776960e3ea56a254ef8f61770711161413c0c","hash":"38f190343bc33fff625627bb778a8fd393146c56a95a5258de73bc28bb4e58ed"},{"ts":"2026-06-29T16:32:28.303Z","model":"gemini/gemini-2.5-flash","action":"collaborate","prompt":"","input":"dsip","response":"I am Gemini, not Grok. I added three tier-honest claims to address gaps in the ledger, focusing on 'what_is_unknown' and 'who_claims_what' from unused sources. I also challenged a claim's tier to improve accuracy.","tokens_in":2774,"tokens_out":539,"cost":0,"prev":"38f190343bc33fff625627bb778a8fd393146c56a95a5258de73bc28bb4e58ed","hash":"59a320ffaef617df2b52ac1425b6dcf4c99ab69344cae96b5051af50853d78e0"},{"ts":"2026-06-29T17:35:47.275Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"59a320ffaef617df2b52ac1425b6dcf4c99ab69344cae96b5051af50853d78e0","hash":"0d16d252d994af03b1d1954f1507764db1046f2f4955ef2f58694df30b0120d7"},{"ts":"2026-06-29T17:36:11.372Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"0d16d252d994af03b1d1954f1507764db1046f2f4955ef2f58694df30b0120d7","hash":"1a85c83d1277709214d6e1afd0cd2582fd4a798f4893184762ca5993ec95fe23"},{"ts":"2026-06-29T17:36:42.818Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"1 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"1a85c83d1277709214d6e1afd0cd2582fd4a798f4893184762ca5993ec95fe23","hash":"a263e35abe4fa7cd2eb0d5eae43b74ba028821ce9d8360fc065db7f468e6624b"},{"ts":"2026-06-29T17:37:22.597Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"a263e35abe4fa7cd2eb0d5eae43b74ba028821ce9d8360fc065db7f468e6624b","hash":"5d675a69a9cec0e7557ecdc5e9c47f808bc623e68ba2125f29bf8c7a6fa7671c"},{"ts":"2026-06-29T17:38:00.187Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"5d675a69a9cec0e7557ecdc5e9c47f808bc623e68ba2125f29bf8c7a6fa7671c","hash":"f98172ebce1fc0d8b2e5f25974ae1c9913a3d820e6b136fce23653cc89ee535a"},{"ts":"2026-06-29T17:38:24.663Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"1 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"f98172ebce1fc0d8b2e5f25974ae1c9913a3d820e6b136fce23653cc89ee535a","hash":"d767b15b4188617195b3e28e1debf237f251c1e34c56fccf57b7b53cf31e13c5"},{"ts":"2026-06-29T17:39:34.793Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"d767b15b4188617195b3e28e1debf237f251c1e34c56fccf57b7b53cf31e13c5","hash":"d5be8e2dfc489e9cdf242d9e5e89f58e801ddf39cbeab010fb7e85e910f15c67"},{"ts":"2026-06-29T17:39:55.139Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"d5be8e2dfc489e9cdf242d9e5e89f58e801ddf39cbeab010fb7e85e910f15c67","hash":"b75e9f054cc8d77e9a13ec2915366b5672621f8ace8785090fa7e861d4c24196"},{"ts":"2026-06-29T17:40:18.712Z","model":"grok-4.3","action":"sources","prompt":"","input":"dsip","response":"1 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"b75e9f054cc8d77e9a13ec2915366b5672621f8ace8785090fa7e861d4c24196","hash":"bddfe88c0fa3b72b1688187814e165841d300d607c85541c10abfa432425b3eb"},{"ts":"2026-06-29T19:27:07.513Z","model":"repair","action":"repair","prompt":"","input":"dsip","response":"{\"materialized\":0,\"before\":[],\"after\":[],\"focus_stats\":{\"roles_assigned\":0,\"excluded_sources\":0,\"commercial_sources\":0,\"cut_claims\":0,\"core\":0,\"cycle\":0,\"adjacent\":19}}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"bddfe88c0fa3b72b1688187814e165841d300d607c85541c10abfa432425b3eb","hash":"bae3a1cd6b2daad8163476567ed1372609ba2e505d26ae44c8a83d0b1fbd3bbe"},{"ts":"2026-06-29T20:41:05.566Z","model":"fill-slots","action":"claim","prompt":"","input":"dsip c115","response":"DSIP: Natural Deep Sleep is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"bae3a1cd6b2daad8163476567ed1372609ba2e505d26ae44c8a83d0b1fbd3bbe","hash":"4a64f40ac023c29b3ec451c98082cf1297e3857ac4e42c2254d152a11851d886"},{"ts":"2026-07-17T02:39:00.989Z","model":"owner","action":"voxel_divide","prompt":"","input":"dsip","response":"15 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4a64f40ac023c29b3ec451c98082cf1297e3857ac4e42c2254d152a11851d886","hash":"b4515962a6ae519046b98b136d980057b8c5e50d6610a3a31a1138ed4d5303d4"},{"ts":"2026-08-04T19:43:10.445Z","model":"opus-5 (claude-code)","action":"bind-sibling-objects","why":"","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"b4515962a6ae519046b98b136d980057b8c5e50d6610a3a31a1138ed4d5303d4","hash":"5d675b5e1d48386f5c2269c2c201c8168b2916f7091c7bbaea9a17635744211c"},{"ts":"2026-08-04T19:47:44.275Z","model":"opus-5 (claude-code)","action":"bind-proven-work-manifest","why":"","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"5d675b5e1d48386f5c2269c2c201c8168b2916f7091c7bbaea9a17635744211c","hash":"55f843cecf6be8b9a48df93e5d7c58290b136ba0d2ba9487af5ba2f6c809dd40"},{"ts":"2026-08-04T19:51:13.647Z","model":"opus-5 (claude-code)","action":"backfill-claim-provenance","why":"","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"55f843cecf6be8b9a48df93e5d7c58290b136ba0d2ba9487af5ba2f6c809dd40","hash":"0df9a1fd87ce9798a5d3045d4fa2fe8cf8c9f18b99e1ff6b654f6a0b99b9985a"},{"ts":"2026-08-04T19:51:47.706Z","model":"opus-5 (claude-code)","action":"rebind-proven-work-manifest","why":"","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"0df9a1fd87ce9798a5d3045d4fa2fe8cf8c9f18b99e1ff6b654f6a0b99b9985a","hash":"605a83374881d326ee7333bcc936cdb40c0ef7522f307f00abc0f39db567c44c"},{"ts":"2026-08-04T19:53:26.232Z","model":"opus-5 (claude-code)","action":"rebind-proven-work-manifest","why":"","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"605a83374881d326ee7333bcc936cdb40c0ef7522f307f00abc0f39db567c44c","hash":"a09fd41b3ed6b36b93c93ac66c0bb653d459a6bdcb4a25e0a06dd81280886438"},{"ts":"2026-08-04T19:58:20.752Z","model":"opus-5 (claude-code)","action":"rebind-proven-work-manifest","why":"","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"a09fd41b3ed6b36b93c93ac66c0bb653d459a6bdcb4a25e0a06dd81280886438","hash":"18ccd04b8f3245c010c7fa0ab6eeb42148aff2c996d0c0c29ab4cffc34fa470f"}],"energy":{"passes":53,"tokens_in":5859,"tokens_out":970,"tokens_total":6829,"cost_usd":0,"models":{"grok/grok-4.3":1,"grok-4.3":26,"system/audit-repair":15,"kimi/moonshot-v1-8k":1,"gemini/gemini-2.5-flash":1,"repair":1,"fill-slots":1,"owner":1,"opus-5 (claude-code)":6},"head":"18ccd04b8f3245c010c7fa0ab6eeb42148aff2c996d0c0c29ab4cffc34fa470f"},"posted_at":"2026-06-29 08:23:19","created_at":"2026-06-29 08:23:19","updated_at":"2026-08-04T20:47:32.083Z","machine":{"shape":"article.machine/v1","slug":"dsip","kind":"article","read":{"human":"https://miscsubjects.com/a/dsip","json":"https://miscsubjects.com/api/articles/dsip","bundle":"https://miscsubjects.com/api/articles/dsip/bundle?format=markdown"},"traversal":{"prev":null,"next":null,"hub":null,"series":null,"position":null,"of":null},"ledger":{"claims":117,"sources":132,"contributions":35,"revisions":67,"objections_url":"https://miscsubjects.com/api/articles/dsip/objections","thread_state_url":"https://miscsubjects.com/api/protocol/thread-state?target=dsip","proof_rule":"An action is proven by its ledger receipt, never by a 200 or a description."},"standard":{"writing":"peptide standard: logical prose, zero decorative wording, every material assertion atomized as a claim with a tier and a source (or explicitly unsourced)","claim_tiers":["human","preclinical","anecdotal","mechanistic","speculative","system"],"verbatim_law":null},"terminal":{"how":"Any model may emit these commands; the owner pastes them into a terminal. $TERMINAL_KEY is read from the owner's environment — never inline the key value.","claim_append":"curl -s -X POST https://miscsubjects.com/api/protocol/claim -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"dsip\",\"text\":\"<one atomized claim>\",\"tier\":\"<human|preclinical|anecdotal|mechanistic|speculative|system>\",\"source_ids\":[],\"who_claims\":\"<model>\",\"rationale\":\"<why material>\"}'","source_append":"curl -s -X POST https://miscsubjects.com/api/protocol/sources -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"dsip\",\"sources\":[{\"type\":\"review\",\"url\":\"<url>\",\"title\":\"<title>\",\"quote\":\"<verbatim quote>\",\"summary\":\"<one line>\"}]}'","objection":"curl -s -X POST https://miscsubjects.com/api/articles/dsip/objections -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"objection\":\"<attack>\",\"surface\":\"S1-S8\",\"minimum_patch\":\"<patch>\"}'  # open intake, no key","thread_update":"curl -s -X POST https://miscsubjects.com/api/protocol/thread-update -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"target\":\"dsip\",\"raw_text\":\"<material delta>\"}'  # open intake, no key","read_back":"curl -s https://miscsubjects.com/api/articles/dsip | python3 -c 'import json,sys; d=json.load(sys.stdin); print(json.dumps(d[\"claims\"][-3:], indent=1))'"}},"representations":{"article":"/a/dsip","json":"/api/articles/dsip","markdown":"/api/articles/dsip/bundle?format=markdown","skill":"/api/articles/dsip/skill","topology":"/api/articles/dsip/topology","versions":"/api/articles/dsip/revisions","invocations":"/api/articles/dsip/invocations"},"editorial_review":{"hero_brief":"A vintage 1970s multi-channel EEG polygraph in a dim laboratory: rows of ink pens on articulated arms writing wavering traces onto a wide continuous roll of chart paper spilling across the bench, the recorded waveforms starting as clean slow oscillations at one end and deteriorating into flat, ambiguous jitter at the other. Warm tungsten light, brushed steel and bakelite instrument housing, grain of analogue film. The chart paper carries only ink waveform traces and a faint blank grid. ABSOLUTELY NO TEXT ANYWHERE: no words, no letters, no numbers, no captions, no titles, no labels, no legend, no annotation, no writing, no watermark, no signature, no logo, no typography of any kind. Pure image only.","headline_subject":"DSIP, whose positive sleep findings never replicated outside the discovering laboratory","hero_subject":"A 1970s multi-channel EEG polygraph writing a sleep trace onto chart paper","visual_action":"The recorded waveform begins as clean slow oscillation and deteriorates into unresolvable jitter along the roll","rationale":"The article turns on a sleep result that fails to hold up; a trace that starts clean and degrades states the replication failure in the instrument's own output.","inspected":true,"inspection_note":"Opened the render at full size and zoomed the instrument panel. Ink pens on articulated arms, chart roll with clean waves at the left degenerating to noise at the right, faint blank grid, dark blurred rack behind. No lettering, numerals, caption, watermark or signature."},"editorial_audit":{"slug":"dsip","ok":true,"issues":[]},"body_hash":"db7378a0da7e244a1aaa67f233c95cbdf14f5355fae96c31465649b9a2e8245c"}}}