# mots c

slug: mots-c · https://miscsubjects.com/a/mots-c · updated 2026-07-17T02:40:30.235Z

## Overview
Evidence is being populated by Grok web search.

## Sources

1. MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity (MOTS-MET) — https://clinicaltrials.gov/study/NCT07505745
2. MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner — https://pubmed.ncbi.nlm.nih.gov/41520850/
3. Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss — https://pubmed.ncbi.nlm.nih.gov/41551324/
4. Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with type 2 diabetes mellitus — https://pmc.ncbi.nlm.nih.gov/articles/PMC12174021/
5. Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes — https://pubmed.ncbi.nlm.nih.gov/40855115/
6. Exploring the therapeutic potential of MOTS-c in age-related macular degeneration — https://pubmed.ncbi.nlm.nih.gov/39961901/
7. Endurance training enhances skeletal muscle mitochondrial respiration by promoting MOTS-c secretion — https://pubmed.ncbi.nlm.nih.gov/39706498/
8. Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea — https://pubmed.ncbi.nlm.nih.gov/40538389/