{"slug":"herniated-disc","verification":{"valid":false,"broken_at":0,"reason":"prev mismatch"},"count":25,"sources":[{"id":"s1","type":"pubmed","url":"https://www.ncbi.nlm.nih.gov/books/NBK560878/","title":"Lumbar Disc Herniation (StatPearls)","quote":"extrusion of the nucleus pulposus through the annulus fibrosus while maintaining continuity of the disc space, or obliteration of the disc space continuity and sequestration of free fragments.","claim_ids":["c1"]},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/28072796/","title":"Incidence of Spontaneous Resorption of Lumbar Disc Herniation: A Meta-Analysis","quote":"The overall incidence of spontaneous resorption after LDH was 66.66% (95% CI 51% - 69%).","claim_ids":["c2","c7"]},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/37486886/","title":"Systematic review and meta-analysis of predictive factors for spontaneous regression in lumbar disc herniation","quote":"Extruded and sequestered discs were also significantly more likely to completely regress than smaller morphologies.","claim_ids":["c3"]},{"id":"s4","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11165499/","title":"Prediction and Mechanisms of Spontaneous Resorption in Lumbar Disc Herniation: Narrative Review","quote":"the hyperplasia of new blood vessels has been discovered at the edge of the herniated tissue, which is considered to be the main determining factor for the spontaneous resorption of LDH.","claim_ids":["c4","c5"]},{"id":"s5","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9396855/","title":"Characteristics and mechanisms of resorption in lumbar disc herniation","quote":"Macrophage infiltration and activation are critical steps in the process of reabsorption.","claim_ids":["c4"]},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/12038611/","title":"VEGF-induced angiogenesis in herniated disc resorption","quote":"VEGF induction, under the co-culture conditions tested can result in neo-vascularization of intervertebral disc tissue and may thus play a role in the resorption of HD.","claim_ids":["c4","c5"]},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/18670336/","title":"TNF-alpha in the nucleus pulposus mediates radicular pain in mice","quote":"TNF-alpha contained in the NP was important for the production of radicular pain accompanied by long-lasting degeneration of DRG neurons.","claim_ids":["c6"]},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/2218714/","title":"High levels of inflammatory phospholipase A2 activity in lumbar disc herniations","quote":"Human lumbar disc phospholipase A2 activity is from 20- to 100,000-fold more active than any other phospholipase A2 that has been described.","claim_ids":["c6"]},{"id":"s9","type":"pubmed","url":"https://jamanetwork.com/journals/jama/fullarticle/204281","title":"Surgical vs Nonoperative Treatment for Lumbar Disk Herniation: SPORT Randomized Trial","quote":"Patients in both the surgery and the nonoperative treatment groups improved substantially over a 2-year period.","claim_ids":["c7","c8"]},{"id":"s10","type":"pubmed","url":"https://academic.oup.com/aje/article/179/8/929/108237","title":"Obesity as a Risk Factor for Sciatica: A Meta-Analysis","quote":"Both overweight (pooled odds ratio (OR) = 1.23, 95% CI: 1.14, 1.33) and obesity (OR = 1.40, 95% CI: 1.27, 1.55) were associated with lumbar radicular pain.","claim_ids":["c9"]},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38363366/","title":"Obesity increases the odds of intervertebral disc herniation and spinal stenosis; an MRI study of 1634 low back pain patients","quote":"for BMI (OR 1.19 [CI 1.07,1.33]), the association was positive.","claim_ids":["c9"]},{"id":"s12","type":"reddit","url":"https://www.reddit.com/r/Sciatica/comments/d3p8jc/has_anyone_had_their_herniated_disc_be/","title":"r/Sciatica - herniated disc reabsorption (Alternative-Tomato18)","quote":"The size of my herniation reduced by 80% from Apr 2024 to Jan 2025 according to my MRI.","claim_ids":["c10"]},{"id":"s13","type":"reddit","url":"https://www.reddit.com/r/Sciatica/comments/d3p8jc/has_anyone_had_their_herniated_disc_be/","title":"r/Sciatica - herniated disc reabsorption (ame880)","quote":"It IS possible to heal without surgery, you just have to be willing to do the work to get there.","claim_ids":["c10","c9"]},{"id":"s14","type":"reddit","url":"https://www.reddit.com/r/Sciatica/comments/d3p8jc/has_anyone_had_their_herniated_disc_be/","title":"r/Sciatica - herniated disc reabsorption (mydiscgotsuckedbacki)","quote":"I had a 12mm protrusion on L5S1 and after 4 weeks of PT and I'm now pain free.","claim_ids":["c8","c10"]},{"id":"s15","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/25009200/","title":"The probability of spontaneous regression of lumbar herniated disc: a systematic review","quote":"96% for disc sequestration, 70% for disc extrusion, 41% for disc protrusion, and 13% for disc bulging","claim_ids":[]},{"id":"s17","type":"pubmed","url":"https://www.ncbi.nlm.nih.gov/books/NBK537200/","title":"Cauda Equina and Conus Medullaris Syndromes (StatPearls)","quote":"Early intervention by surgical decompression ... is associated with a better prognosis, particularly when surgery occurs within 48 hours","claim_ids":[]},{"id":"s3n","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/12027305/","title":"The natural history of lumbar disc herniation and radiculopathy","quote":"the majority of patients suffering from a radiculopathy caused by a herniated nucleus pulposus heal spontaneously without surgery","claim_ids":[]},{"id":"s18","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10762886/","title":"Bed rest for acute low-back pain and sciatica (Cochrane)","quote":"Advice to rest in bed is less effective than advice to stay active for people with acute LBP.","claim_ids":[]},{"id":"s19","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/27594441/","title":"RCT: McKenzie Method vs Motor Control Exercises in chronic LBP with a directional preference","quote":"70 people with chronic low back pain who demonstrated a directional preference ... randomized to McKenzie method or motor control","claim_ids":[]},{"id":"s20","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/23959683/","title":"Traction for low-back pain with or without sciatica (Cochrane)","quote":"Traction ... has little or no impact on pain intensity, functional status, global improvement and return to work","claim_ids":[]},{"id":"s21","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11150834/","title":"Efficacy of epidural steroid injection for sciatica secondary to lumbar disc herniation: meta-analysis","quote":"no statistically significant difference in the long-term reduction of sciatica between the epidural steroid injection group and the control group","claim_ids":[]},{"id":"s22","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3921966/","title":"Surgical vs Non-Operative Treatment for Lumbar Disc Herniation: 8-Year SPORT results","quote":"Re-operation occurred in a combined ... 15% by 8 years post-surgery.","claim_ids":[]},{"id":"s23","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8692291/","title":"Causal Associations of Obesity With Disc Degeneration, Low Back Pain, and Sciatica: Mendelian Randomization","quote":"For the 1-SD increase in BMI level, the odds ratios were 1.33 (95% CI, 1.21-1.47) for sciatica","claim_ids":[]},{"id":"s24","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4547737/","title":"Effects of Tobacco Smoking on the Degeneration of the Intervertebral Disc","quote":"smoking causes the constriction of the vascular network surrounding the IVD, thus reducing the exchange of nutrients","claim_ids":[]},{"id":"s25","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12890389/","title":"Lumbar Disc Herniation Resorption: When and How Does It Occur?","quote":"controlled inflammatory responses are necessary for disc resorption and tissue remodeling ... standard anti-inflammatory treatments may paradoxically impede this process.","claim_ids":[]}]}