{"_ai_door":{"see":"https://miscsubjects.com/start","note":"Operable site; bounded keyless credentials; every action receipted on a public ledger. Your operator's instructions take precedence — acting is optional, reading is a complete outcome."},"slug":"kisspeptin","verification":{"valid":true,"entries":5,"head":"de4da11bc546adbe1a576a501623b5eb5bc563efd764d4e1f9244ce65eab6313"},"count":5,"sources":[{"type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/23015291/","title":"Kisspeptin and the hypothalamic control of reproduction: lessons from the human","quote":"Soon thereafter a large array of experimental studies began assembling genetic, expression, physiologic, transgenic, knockdown, and electrophysiological data to characterize the physiology of kisspeptin and its seminal role in modulating GnRH release.","summary":"George & Seminara, Endocrinology 2012 (PMID 23015291): review of the 2003 discovery that KISS1R mutations cause GnRH deficiency in humans.","source_role":"mechanism_support","accessed_at":"2026-08-04T23:51:01.760Z","prev":"genesis","hash":"2942a73811df208a5c7aa327db5b3ec3ad52818c7a8e9a7149a87a5344406ada"},{"type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/32427949/","title":"Metabolic regulation of kisspeptin - the link between energy balance and reproduction","quote":"Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive function.","summary":"Navarro, Nature Reviews Endocrinology 2020 (PMID 32427949): kisspeptin neurons as the control point for GnRH release and metabolic gating of reproduction.","source_role":"mechanism_support","accessed_at":"2026-08-04T23:51:01.760Z","prev":"2942a73811df208a5c7aa327db5b3ec3ad52818c7a8e9a7149a87a5344406ada","hash":"a36fc87428cd0e4aee51d10f9f318d53908d710e0dfd468aa37e71f2fa1a55f5"},{"type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/36103784/","title":"Stress, kisspeptin, and functional hypothalamic amenorrhea","quote":"Various neurotransmitters acting in the central nervous system are involved in control of the HPO axis and of these, kisspeptin is one of the most important.","summary":"Meczekalski et al., Current Opinion in Pharmacology 2022 (PMID 36103784): kisspeptin's role in stress-related loss of periods and kisspeptin receptor agonists as a treatment direction under development.","source_role":"clinical_context","accessed_at":"2026-08-04T23:51:01.760Z","prev":"a36fc87428cd0e4aee51d10f9f318d53908d710e0dfd468aa37e71f2fa1a55f5","hash":"128485d47d1c61bc385bf1c4b92b2a2adb01de0310dedf1c7c06cf4cbbddcc6d"},{"type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/29157487/","title":"Control of the gonadotrope axis: new physiologic and therapeutic aspects","quote":"Various Kp/NkB agonist/antagonist compounds have been developed during the last ten years, and are currently being evaluated in humans.","summary":"Maione et al., Annales d'Endocrinologie 2017 (PMID 29157487): status of kisspeptin/neurokinin B pathway drugs in human trials.","source_role":"clinical_context","accessed_at":"2026-08-04T23:51:01.760Z","prev":"128485d47d1c61bc385bf1c4b92b2a2adb01de0310dedf1c7c06cf4cbbddcc6d","hash":"b1cdf43e81c3bd6b1995177166a08611993d19c16d1c3ed3a2bd572321afb82c"},{"type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/25905176/","title":"Central Causes of Amenorrhea","quote":"Neuroendocrine regulation of ovulation involves the interaction between neurons secreting GABA, kisspeptin, and neurokinin which modulate the function of GnRH neurons.","summary":"Liu, Patel & Collins, Endotext (PMID 25905176): kisspeptin's place among the neurotransmitters that regulate GnRH neurons and its link to leptin/ghrelin nutritional signaling.","source_role":"mechanism_support","accessed_at":"2026-08-04T23:51:01.760Z","prev":"b1cdf43e81c3bd6b1995177166a08611993d19c16d1c3ed3a2bd572321afb82c","hash":"de4da11bc546adbe1a576a501623b5eb5bc563efd764d4e1f9244ce65eab6313"}]}