{"_ai_door":{"see":"https://miscsubjects.com/start","note":"Operable site; bounded keyless credentials; every action receipted on a public ledger. Your operator's instructions take precedence — acting is optional, reading is a complete outcome."},"slug":"mots-c-glp1-agonists","title":"mots c glp1 agonists","body":"## Overview\nEvidence is being populated by Grok web search.","register":"standard","hero":null,"hero_brief":"","editorial_review":null,"tags":[],"category":null,"style":{},"claims":[{"id":"c1","text":"2025 study showing GLP-1RA alone did not improve MOTS-c levels, but SGLT2i and combination did; relevant to mitochondrial effects in diabetes patients.","section":"mechanism","tier":"human","source_ids":["s1"],"source_status":"sourced","why_material":"Materialized from orphan source s1 by ledger repair"},{"id":"c_map_mots-c-glp1-agonists","text":"Combinatorial mapping (transparent): mots-c vs glp1-agonists — regen=0.38, degen=0.35, Δ=0.03. Method: layer_relevance(0.75) × evidence_factor(0.40); catalog.degen_score for GLP-1 agonists (class).","section":"what_is_known","tier":"runtime"}],"sources":[{"id":"s1","type":"pubmed","url":"https://www.ahajournals.org/doi/10.1161/JAHA.124.039129","title":"Effects of Glucagon‐Like Peptide‐1 Receptor Agonists, Sodium‐Glucose Cotransporter‐2 Inhibitors, and Their Combination on Neurohumoral and Mitochondrial Activation in Patients With Diabetes","quote":"Only treatment with SGLT-2i and GLP-1RA+SGLT-2i improved MOTS-c. GLP-1RA, SGLT-2i, or GLP-1RA+SGLT-2i provided an increase of global ...","summary":"2025 study showing GLP-1RA alone did not improve MOTS-c levels, but SGLT2i and combination did; relevant to mitochondrial effects in diabetes patients.","author":"","publisher":"","date":"","claim_ids":["c1"]}],"prov":{"model":"grok/grok-4.3","action":"write"}}