{"slug":"paper-goldbeter-a-1972-dissipative-structures-for-an-allosteric-model-application-to-g","verification":{"valid":true,"entries":1,"head":"4ab72d0341c69e68a70e322b8b1637b7a9248dd3bdec98cd9e1c4d4976190136"},"count":1,"sources":[{"id":"s1","type":"other","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1484224/","title":"Dissipative Structures for an Allosteric Model: Application to Glycolytic Oscillations","quote":"An allosteric model of an open monosubstrate enzyme reaction is analyzed for the case where the enzyme, containing two protomers, is activated by the product. It is shown that this system can lead to instabilities beyond which a new state organized in time or in space (dissipative structure) can be reached. Sustained oscillations in the product and substrate concentrations are shown to occur for acceptable values of the allosteric and kinetic constants...","summary":"1972 Biophysical Journal paper by Goldbeter and Lefever demonstrating limit cycles in an allosteric enzyme model for glycolysis.","claim_ids":["c1","c2","c3","c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-07-07T20:49:09.172Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"4ab72d0341c69e68a70e322b8b1637b7a9248dd3bdec98cd9e1c4d4976190136"}]}