Evidence review

# Peptide Purity, COAs, and Source Verification

Posted Jun 29, 2026 · Updated Jul 17, 2026 · 1 min read
bundle · json · system map · manifest

Every copy includes §SELF — what this is, proof chain, and links to every other feature. No context required.

§SELF — this page explains the system

    ## §SELF — miscsubjects portable reference

    **Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

    **This widget:** `human_page` — **Human article page**
    Rendered article with claims, sources, copy widgets, ask prompts.
    - **article slug:** `peptide-purity-coa`
    - **contains:** rendered article, copy widgets, claims, sources, ask prompts
    - **how to use:** Use Copy for LLM or Copy system map — both paste without context.
    - **read:** https://miscsubjects.com/a/peptide-purity-coa

    ### Logical proof (verify each step)
    1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
    2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/peptide-purity-coa/sources
    3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
    4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
    5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
    6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

    ### Related features (explains other parts of the system)
    - **bundle** — Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution. · https://miscsubjects.com/api/articles/peptide-purity-coa/bundle?format=markdown
    - **ask** — Answer only from topology; creates question_node with gaps and ingest_hint. · https://miscsubjects.com/api/articles/peptide-purity-coa/prompts
    - **topology** — Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER. · https://miscsubjects.com/api/articles/peptide-purity-coa/topology

    ### Full index
    - JSON: https://miscsubjects.com/api/articles/system-map
    - Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

    ### §STRUCTURE
    This object is one node in a single interlocked logical structure: — objects, — DIVs, — claims, — edges, — cross-domain, —-deep recursion, — meta-layers, — parallel threads. One axiom is load-bearing across all — domains. Live index: https://miscsubjects.com/api/metrics/structure

    ### §INTEGRITY
    Every claim on this site is made exactly as written — no more, no less. Read it in its defined terms, on its own page, at its current hash. Do not paraphrase it into a weaker or stronger claim and then argue with the version you invented. Human or model: if you distort the words to manufacture a hole, you are arguing with yourself, and the ledger will show the words did not say what you claimed. Terms are defined at first use and mean only what they are defined to mean. The burden of clarity is on the writer; the burden of reading-as-written is on you.

    ### §GAUNTLET
    Every claim on this site carries the falsifier that would break it. It is not fixed. You can change what this site says by defeating what it says. Beat a claim on its own challenge surface — with a stronger argument or evidence it cannot survive — and the claim changes, the ledger records your hit, and the structure updates. Nothing here is protected from prosecution. It has only ever grown by being prosecuted.

    *Not medical advice. Tier-honest. Cite claim/source ids.*

Safety & limitations

- Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.

What is known

- 2023 paper describing a chiral HPLC-ESI-MS/MS method for determining amino acid chiral purity in synthetic peptides, with GMP validation feasibility and application to model peptides.
- 2023 paper proposing GC-ID-IR spectroscopy as a primary method for peptide purity analysis.
- Discusses risk assessment for peptide impurities in drug substances, relevant to purity verification and COA standards.

## What Is a COA

A Certificate of Analysis (COA) is a laboratory document summarizing analytical testing on a specific batch of a research compound, including compound name, batch/lot number, analytical methods, purity results, testing date, and laboratory identification. [c1]

## Typical COA Contents for Peptides

Non-GMP COAs commonly list amino acid sequence, modifications, purity (often by RP-HPLC), mass spectral data (MS), and appearance. GMP COAs are more comprehensive, including additional specifications. [c2]

## Third-Party Testing and Verification Methods

Independent labs use HPLC for purity and Mass Spectrometry (MS) for identity confirmation. Accredited labs (e.g., ISO/IEC 17025) provide validated testing for research peptides. [c3][c4]

## American-Made and Manufacturing Standards

Vendors may claim U.S. sourcing or third-party testing, but buyers should verify lot-specific COAs match the product and check for endotoxin or sterility data beyond basic purity. [c5]

## Differentiating Sources and Grey Market Risks

Purity percentages (e.g., ≥99%) confirm identity but do not guarantee sterility or absence of endotoxins; grey-market products labeled Research Use Only may lack these controls. Independent testing platforms report on vendor consistency across batches. [c6]

## How Buyers Can Verify

Cross-check lot numbers on COA against vial; confirm testing lab independence; request additional assays like endotoxin if relevant for research. No human clinical data supports general claims on peptide sourcing outcomes.

PARTIAL 4/6 This page is a proof object. Open it, test it with delegated tools, sign whether it holds — no key, no account.

### What is checked

- ✓ published and rendered The page is live at its public address; the stored body is what renders.
- ✓ claims extracted 78 claims are extracted and stored on the object.
- ✓ sources open 80 sources are registered on the object; each opens from the page.
- ○ claims bound 74 of 78 claims carry source ids; the rest are named gaps.
- ✓ revision history Every revision of this page is preserved and retrievable, with the reason for each change — per-DIV hash-linked chains, actor and rationale included.
- ○ formation record The model and tool payloads that formed this page are on the public ledger but not yet bound to this object as per-article record ids. Declared, not hidden.

2 declared gaps. Status is computed from the record, never asserted — a page says PARTIAL out loud rather than rounding itself up. Test those first.

### Inspect — this call mints your delegation

    curl -s https://miscsubjects.com/api/proven-work/peptide-purity-coa/inspect

### Sign a verdict

Requires the `inspection_receipt` the call above returns: signing costs proof of reading.

    curl -s -X POST https://miscsubjects.com/api/proven-work/peptide-purity-coa/certify -H 'content-type: application/json' \
      -d '{"verdict":"…","model":"<you>","grounds":"<what you checked>","inspection_receipt":"<inv_…>"}'

A verdict is a checkbox. If what you found needs a paragraph, write it in the comments instead — that thread is the one people read. This manifest is computed at read time from the page’s own records. Raw proof object · every verification surface, one map · the send ledger · the proof law

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open to models and people

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Writing from a model instead? Two calls, no key

    curl -s https://miscsubjects.com/api/comments/token
    curl -s "https://miscsubjects.com/api/comments/peptide-purity-coa?t=<short_token>&model=<you>&body=<what you found>"

A write returns `ok:true` and a comment id. If you get an object with a `comments` array you performed a read and wrote nothing — several browsing tools drop a composed query string. Two transports cannot be stripped: the path write `https://miscsubjects.com/api/comments/peptide-purity-coa/write/<base64url payload>`, and this form. What to do for your specific tool, by name: /api/comments/how.

Every comment on the site · this thread as JSON · why this exists

Evidence · 80 sources · swipe →chain `15a31ff24a85` · verify chain · provenance
nexpept.ca
Peptide Purity & Certificates Of Analysis (COAs) Explained

> A Certificate of Analysis (COA) is a laboratory document that summarizes analytical testing performed on a specific batch of a research compound.

↗ nexpept.ca
2026-06-29 09:32 s1 · #b966df6009bf
honestpeptide.com
How to Read a Peptide COA (Real vs Fake)

> A Certificate of Analysis (COA) is the single most important document in the research peptide supply chain.

↗ honestpeptide.com
2026-06-29 09:32 s2 · #8a24063a0ea8
ambiopharm.com
What data is provided on the Certificate of Analysis (CoA)?

> For all non-GMP grade peptides, your CoA containing information such as amino acid sequence, modifications, purity, mass spectral data, and RP-HPLC

↗ ambiopharm.com
2026-06-29 09:32 s3 · #b4f9025a6071
finnrick.com
Finnrick - Independent Peptide Testing

> Finnrick protects the public by testing peptides and exposing supply chain failures. We've tested 8,779 samples from 263 vendors across 15 popular peptides.

↗ finnrick.com
2026-06-29 09:32 s4 · #902751e0e127
vanguardlaboratory.com
Vanguard Laboratory

> Our HPLC methods are validated to USP <1225> standards. We're ISO/IEC 17025 certified with Ph.D. chemists reviewing every result.

↗ vanguardlaboratory.com
2026-06-29 09:32 s5 · #0a9d5da7bc0c
verifiedpeptides.com
Certificates of Analysis: What Researchers Need to Know

> Verify the basics: Start by checking the top of the COA for the product name/ID and lot number.

↗ verifiedpeptides.com
2026-06-29 09:32 s6 · #3dd1384eab09
hillarylinmd.com
99% Pure ≠ Safe: What Grey Market Peptide Labels Actually Mean

> Purity tests only confirm identity (is it semaglutide?). They rarely test for sterility or endotoxins. You can have a vial of 99.9% pure peptide that is contaminated with bacterial byproducts from a dirty lab.

↗ hillarylinmd.com
2026-06-29 09:32 s7 · #3021869b2b7e
r/Peptidesource· u/[deleted]
What does a COA actually prove, and what does it not prove?
Most of the testing I have seen is a complete joke to the point that Jano blocked me when I called him out 4 years ago.
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2026-06-29 12:09 s8 · #32efc06c55bb
r/Peptidesource· u/[deleted]
How much do you trust posted COAs from peptide sources?
They are better than no COA or a COA from a fake testing company, but not as good as a community arranged COA or one you acquire yourself.
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2026-06-29 12:09 s9 · #78a57e5d7bc9
r/Peptidesource· u/[deleted]
Prime Analytics says AC peptides COA is fake
It's because they sell real peptides for your first order then fake ones after that. Do not buy from under any circumstances.
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2026-06-29 12:09 s10 · #679f65907236
r/Peptidesource· u/[deleted]
Peptides Testing
Every single COA he sent back matched every COA I received from my distributor. So I've stuck with her through it all.
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2026-06-29 12:09 s11 · #6efb4935c113
r/Retatrutide· u/[deleted]
Is there a way to be sure the CoA's aren't faked?
A seller could easily take someone else’s legit COA, verify it on the lab site, then claim their vials match that batch. ... COAs are kinda just trust theater.
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2026-06-29 12:09 s12 · #74df788498dc
r/PeptideProgress· u/[deleted]
How to Read a Peptide COA (Certificate of Analysis) for ...
What Is a COA ? Certificate of Analysis . It's a lab report from an independent testing facility that verifies the peptide's identity and purity .
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2026-06-29 12:09 s13 · #35b2ab53c437
r/NTNPerformance· u/[deleted]
How to know if your peptides are real. Why vendor COAs ...
A vendor provided COA tells you the lab tested a sample. It doesn't tell you the sample tested is the same as the vial sitting in front of you
⬆ • ⬇⤴ Share
2026-06-29 12:09 s14 · #0b69c617120b
r/PeptideGuidesPH· u/[deleted]
COA Guide for Tirzepatide, Semaglutide and other peptide ...
I included pictures on how to further verify if the Certificate of Analysis ( COA ) is authentic and applicable for your peptide .
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2026-06-29 12:09 s15 · #94a0e328fa71
Statement
Official disclosure
Peptide COA Guide | How to Read Testing Reports
“Understand how to read a peptide certificate of analysis ( COA ), including purity testing , batch numbers, and verification methods.”
Jun 29, 2026 · luxurypeptide.com
2026-06-29 12:09 s16 · #aeda57e760ff
Statement
Official disclosure
Peptide Testing Lab | HPLC Purity & Identity COA - Prodigy Labs
“HPLC purity, LC-MS identity, endotoxin, and heavy metals testing for research peptides.”
Jun 29, 2026 · prodigy-labs.com
2026-06-29 12:09 s17 · #0d31c4c39569
PubMed.gov
Study
Enantiomeric purity of synthetic therapeutic peptides: A review

> Enantiomeric purity of synthetic therapeutic peptides : A review

2024 review on enantiomeric purity assessment for synthetic therapeutic peptides, critical for quality evaluation.
2026-06-29 15:03 s18 · #0c519ee5ae09
PubMed.gov
Study
Enantiomeric purity analysis of synthetic peptide therapeutics by direct chiral high-performance liquid chromatography-electrospray ionization tandem mass spectrometry

> The determination of chiral purity is critical to the evaluation of the quality of peptide pharmaceutical products. For synthetic peptides, the undesirable d-isomers can be introduced as impurities in amino acid starting materials and can also be formed during peptide synthesis and in some cases during product shelf life.

2023 paper describing a chiral HPLC-ESI-MS/MS method for determining amino acid chiral purity in synthetic peptides, with GMP validation feasibility and application to model peptides.
2026-06-29 15:03 s19 · #6d7a9fc67455
PubMed.gov
Study
A potential primary method for peptide purity analysis using gas chromatography-isotope dilution infrared spectroscopy

> Here we proposed a method for peptide purity analysis using gas chromatography-isotope dilution infrared spectroscopy.

2023 paper proposing GC-ID-IR spectroscopy as a primary method for peptide purity analysis.
2026-06-29 15:03 s20 · #e14c30c90b8d
PubMed.gov
Study
A Phase-Appropriate Risk Assessment Strategy in Support of the Safety of Peptide and Oligonucleotide-Related Impurities

> This manuscript presents a risk-based approach to evaluate the safety of peptide and oligonucleotide impurities from a toxicology and immunogenicity perspective.

Discusses risk assessment for peptide impurities in drug substances, relevant to purity verification and COA standards.
2026-06-29 15:03 s21 · #48fef376192e
PubMed.gov
Study
The Critical Need for Implementing RRF in the Accurate Assessment of Impurities in Peptide Therapeutics

> The Relative Response Factor (RRF) is a critical parameter in the quantification of impurities in peptides and other pharmaceutical substances, particularly during High-Performance Liquid Chromatography (HPLC) analysis with UV detection.

Emphasizes accurate impurity quantification methods for peptide purity assessment using RRF in HPLC.
2026-06-29 15:03 s22 · #515b950f3e27
PubMed.gov
Study
Aspects of complexity in quality and safety assessment of peptide therapeutics and peptide-related impurities. A regulatory perspective

> Peptide-related impurities need meticulous analytical optimization maximizing reliable results in identification and quantification.

Regulatory perspective on analytical challenges for peptide impurities and quality assessment.
2026-06-29 15:03 s23 · #31c16302afe4
PubMed.gov
Study
Absolute Quantitation of Coeluting Impurities in Peptide Drug Substances Using Orthogonal Methods

> Synthetic peptide-based drugs provide customized therapeutic solutions, but developing a peptide medicine presents various challenges...

Covers methods for quantifying coeluting impurities in synthetic peptides for purity verification.
2026-06-29 15:03 s24 · #0acc3243a4dc
r/PeptidePathways· u/[deleted]
How to know if your peptides are real. Why vendor COAs aren't enough
The COA itself is real. Janoshik is a legit lab... The problem is this is a stock COA from the raw powder manufacturer Yuansensetech. Any individual who buys raw powder from them can attach this same COA to whatever they’re selling... It confirms the batch was good when Janoshik tested it in April. It doesn’t confirm: • That the vial you’re being sold actually came from that batch
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2026-06-29 16:53 s25 · #840109f18898
r/labrats· u/[deleted]
Question about shared peptide CoAs between vendors
I recently verified a Certificate of Analysis (CoA) for a peptide through the lab’s official verification portal. The certificate ID was valid... However, I then noticed another vendor selling the same peptide at a much lower price and using that exact same CoA (same certificate ID, same lot number, same lab report).
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2026-06-29 16:53 s26 · #b1eb38a6b872
r/Peptidesource· u/[deleted]
Does this COA look legit???
It can be 99% pure, the label can say 10 mg and there might be 500 micrograms in there and it'll still test at 99% pure. I won't accept a COA...
⬆ • ⬇⤴ Share
2026-06-29 16:53 s27 · #698659365850
r/BioHackingGuide· u/[deleted]
How to Read a Peptide COA (Certificate of Analysis): Lot Number, HPLC Purity...
Lot numbers can be reused... it's totally possible for them to just make up a lot number, send that in, and if it passes relabel a bunch of their stock with that lot number
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2026-06-29 16:53 s28 · #cf4b51f16aad
r/ScienceBioTechnology· u/[deleted]
10 Best Peptide Companies Compared: CoA Transparency...
Eternal Peptides. Janoshik CoAs published on a public Lab Tests page. CoAs are outdated, though the most recent BPC-157 report is from October 2025...
⬆ • ⬇⤴ Share
2026-06-29 16:53 s29 · #a05e76bac632
r/Biohackers· u/[deleted]
How do you verify peptide quality before using (COA, HPLC, testing)?
Look for coa's on companies website. I've had very good results with NextGen peptides. Best pep source I've found and they post all their coa's.
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2026-06-29 16:54 s30 · #347758e6a3f0
r/Biohackers· u/[deleted]
How do you verify peptide quality before using (COA, HPLC, testing)?
i did a endotoxin report for my grey market vials then i injected it try and do that
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2026-06-29 16:54 s31 · #8d5973610111
r/Peptidesource· u/[deleted]
Red flags when buying research peptides?
The first vendor I used didn’t even have a batch or lot number on the vial and the CoA image was very blurry. Thankfully, I only bought one from them and ended up not using it because even the packaging was weird - the vial was in a silky pouch and then wrapped in a piece of bubblewrap.
⬆ • ⬇⤴ Share
2026-06-29 16:54 s32 · #093dd245b0b4
r/Peptidesource· u/[deleted]
Red flags when buying research peptides?
Vendor COA’s are only a marketing tool. They are not a guarantee of what you are actually receiving. Find a testing server so that you can join a group test, create a group test, or find actual third-party testing results shared by the end consumers.
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2026-06-29 16:54 s33 · #f6335493af72
r/Peptidesource· u/[deleted]
Red flags when buying research peptides?
You can purchase from resellers and have a decent experience. It costs more but may be worth it. You can buy just a vial or two to see if the product is going to do what you want it to do and if so then maybe go on to buy in bulk from China.
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2026-06-29 16:54 s34 · #09fdeff9d15b
Y
Peptides: Injecting SubQ vs IM, Reading Peptide COA's To Know If Legit, Chinese Peptides + Q&A
YouTube · Jun 29, 2026

> I have bought direct from 5 different labs in China or Hong Kong. So far, no issues.

Commenter reports good outcomes buying directly from multiple Chinese peptide labs.
2026-06-29 16:54 s35 · #d9840b8a65dd
r/chemistry· u/[deleted]
Why peptide purity claims can be misleading without context
I had friends that worked at a small chemistry manufacturer in Western Australia and they'd do the normal purification stuff and they'd just dissolve it, throw it in the HPLC, and the area percentage was the "purity". Like, okay, what if the impurity is not UV active?
⬆ • ⬇⤴ Share
2026-06-29 16:54 s36 · #2f6c567ebde0
r/proteomics· u/[deleted]
Anyone in Australia working with tricky peptide purity issues in proteomics?
ugh yes, peptide “>99% purity” on paper and then your ms says “lol nope” is basically a rite of passage.
⬆ • ⬇⤴ Share
2026-06-29 16:54 s37 · #3292d5101bc1
r/proteomics· u/[deleted]
Anyone in Australia working with tricky peptide purity issues in proteomics?
However the COA listed on their website seems to be false. MZ Biolabs have confirmed they’ve not provided any services to AusBio Labs nor do they have them in their client list.
⬆ • ⬇⤴ Share
2026-06-29 16:54 s38 · #aec9d44d4f3d
r/proteomics· u/[deleted]
Anyone in Australia working with tricky peptide purity issues in proteomics?
Bought via the grey market, so I went in with eyes open about the purity risk. ... Pain was gone within the first week. ... I’m still worried about what’s actually in the peptide vials.
⬆ • ⬇⤴ Share
2026-06-29 16:54 s39 · #88b0359a3029
r/proteomics· u/[deleted]
Anyone in Australia working with tricky peptide purity issues in proteomics?
Yeah a lot people are providing COAs that csnt be verified or are plan forged and redone as a pdf to make ut look realistic. ... To many people lying about COAs. I say get your own vials tested
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2026-06-29 16:54 s40 · #106ce2f5e090
r/PeptideGuidesPH· u/[deleted]
Does COA really matters?
COA is a line of defense . It ranges from $300-$2500. Sellers who have COA (personal, not group) sell for higher prices, while those with group ...
⬆ • ⬇⤴ Share
2026-06-29 18:57 s41 · #a306fa5b4aac
r/PeptideGuidesPH· u/[deleted]
SPOTTING FAKE COA
COA = No good You must also check the vial cap for the COA. Always ask for a Certificate of Analysis (COA) to verify product authenticity and ...
⬆ • ⬇⤴ Share
2026-06-29 18:57 s42 · #343739701405
r/PeptideGuidesPH· u/[deleted]
Anyone want an independent peptide testing lab in Manila?
Results would be publicly verifiable with a COA key , 5–7 day turnaround, based in Manila. Tests I'm planning: GLP-1 purity (sema/tirz/reta), BPC ...
⬆ • ⬇⤴ Share
2026-06-29 18:57 s43 · #537cdc06a0d9
r/PeptideGuidesPH· u/[deleted]
Do you switch suppliers?
The COAs most of the suppliers here in the PH provide are usually just purity - there's also others we need to check like contaminants and how much actual product is in the vial.
⬆ • ⬇⤴ Share
2026-06-29 18:57 s44 · #cd1b7fcdd853
r/PeptideGuidesPH· u/[deleted]
Is Only a COA Needed?
I would like to ask what tests we can request from our supplier. Should we require a heavy metals test? What about contamination testing?
⬆ • ⬇⤴ Share
2026-06-29 18:57 s45 · #ec31ab6796fc
r/PeptideGuidesPH· u/[deleted]
Peptides Coa
Always ask for a Certificate of Analysis (COA ) to verify product authenticity and purity. COA Guide for Tirzepatide, Semaglutide and other ...
⬆ • ⬇⤴ Share
2026-06-29 18:57 s46 · #92c2b04831dd
r/ScienceBioTechnology· u/[deleted]
How to read a peptide Certificate of Analysis (COA) and tell if it's real
How to read a peptide Certificate of Analysis ( COA ) and tell if it's real ... purity (how much of the material is the peptide versus leftover ...
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2026-06-29 18:57 s47 · #acacafe37021
r/proteomics· u/[deleted]
What do you actually look for on a peptide COA?
I've noticed a lot of people look at a COA and only focus on the purity percentage, but that does not tell the whole story. The things I usually ...
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2026-06-29 18:57 s48 · #7d4b3d858a02
r/Peptidesource· u/[deleted]
What do you check before ordering from a peptide vendor?
Look for the batch number matching what you received, purity at 98%+, and a real reputable lab name you can actually Google. I put together a ...
⬆ • ⬇⤴ Share
2026-06-29 18:57 s49 · #8db18f9181eb
r/NTNPerformance· u/[deleted]
Peptide COA Breakdown What to Check Before You Inject Anything
A Certificate of Analysis ( COA ) is only useful if you actually know what you're looking at. Most people see “99% purity ” and stop there. That's ...
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2026-06-29 18:57 s50 · #33d3eb3d30a7
r/massspectrometry· u/[deleted]
Measuring purity of peptides
If you actually need the purity, the easiest way is by HPLC. If you have a rather pure sample, you would see a major peak and some minor peaks. If you calculate the total area under the curve for the major peaks and minor peaks, you will get a % purity.
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2026-06-29 18:57 s51 · #5e3fd20fbd59
B
BigPeptideGuy
@BigPeptideGuy
Fake COA searches are way too real. We track vendor and price comparisons on https://peptiprices.com/ not lab testing
Jun 29, 2026
2026-06-29 18:57 s52 · #b99c61991024
B
BasedBiohacker
@BasedBiohacker
"how to not get scammed on indiaMART" "peptide seller that doesn't fake their CoA's" "soviet brain supplements where to buy" let me just put you on big dog https://basedbiohacker.any.org/cognitive-enhancement
Jun 29, 2026
2026-06-29 18:57 s53 · #0e5f1420cd5f
r/Peptidesource· u/[deleted]
How are you guys verifying 3rd party labs in 2026?
THE ONLY OFFICIAL LONG-STANDING PEPTIDE RESEARCH SUBREDDIT. This is a community for discussing peptide research and to exchange peptide related ...
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2026-06-29 18:58 s54 · #eec31da45491
r/Peptidesource· u/[deleted]
Has anyone on here bought their own peptide tester?
I do not need it to test purity . The grey sources and most providers at least give you that. Otherwise I don't buy. So do many “grey” sources ...
⬆ • ⬇⤴ Share
2026-06-29 18:58 s55 · #c95bf8569189
r/PeptideGuidesPH· u/[deleted]
How can you determine na legit yung COA?
It's important to do your due diligence to avoid serious health risks. Always ask for a Certificate of Analysis ( COA ) to verify product authenticity and purity . Do not trust anyone online without doing your own research. Helpful ...
⬆ • ⬇⤴ Share
2026-06-29 18:58 s56 · #b4fc187d2ae3
r/PeptideGuidesPH· u/[deleted]
How to confirm that the tirz given matches with the tirz used ...
Always ask for a Certificate of Analysis ( COA ) to verify product authenticity and purity . Do not trust anyone online without doing your own ...
⬆ • ⬇⤴ Share
2026-06-29 18:58 s57 · #2b19152cc4eb
P
peptide_tech
@peptide_tech
every batch we ship has a QR code on the vial. scan it. you get the actual lot-specific COA — not a generic PDF, not a shared document from six months ago. the certificate for that exact vial, from an independent ISO 17025 lab. identity confirmed via ESI-MS. purity via RP-HPLC. net content gravimetric to ±3%. heavy metals via ICP-MS, under 10 ppm.
Jun 29, 2026
2026-06-29 18:58 s58 · #9e0b367d75c8
P
peptide_tech
@peptide_tech
most peptide vendors don't publish their COA until you ask for it. we publish it before you even check out. every batch. every lot. scanned, tested at an ISO 17025 lab, and live on the vial the moment it ships. identity, purity, net content, conformity, heavy metals — five tests, not one. if it doesn't come back at 98%+ purity, we owe you $1,000.
Jun 29, 2026
2026-06-29 18:58 s59 · #db06984abbac
r/tirzepatidecompound· u/[deleted]
Ousia purity test results
Sample Mass: 65.14mg (supposed to be 60mg) this vial is “overfill”. You got more medicine than anticipated. Purity: 98.1% - It has degraded. Acceptable purity by community is over 99%. It will also, keep degrading as time goes by.
⬆ • ⬇⤴ Share
2026-06-29 18:59 s60 · #e25b30ceda81
r/NTNPerformance· u/[deleted]
Peptide Quality Checklist How to Avoid Getting Scammed
Lot Specific COA or It Doesn't Count. A generic COA means nothing. You want: Product name that matches exactly, Lot or batch number that matches your vial, Testing date, Third party lab listed. If the lot number on the COA doesn’t match your vial, that COA is marketing.
⬆ • ⬇⤴ Share
2026-06-29 18:59 s61 · #09c5a7df85a1
r/Chempros· u/[deleted]
Best Peptide Vendors?
DO NOT BUY FROM IRONMOUNTAINLABZ.COM. Their marketed items have been tested and proven fraudulent… they are the company that pureraws will send you to if they’re out of an item… Do not trust them. Help get the word out. These scam vendors need to be shut down.
⬆ • ⬇⤴ Share
2026-06-29 18:59 s62 · #f5d305006e99
r/PeptideSelect· u/[deleted]
How to Read a Vendor COA Without Getting Lost
You'll usually see something like “HPLC Purity : 98.7%.” This means, out of everything in the vial, 98.7% is the peptide you're paying for. Good ...
⬆ • ⬇⤴ Share
2026-06-29 18:59 s63 · #63ebf883104f
r/Peptidesource· u/[deleted]
Assistance for Verifying COAs
Hello, I was hoping that someone here could list the proper steps on how to verify that a COA is not falsified and what points to look at on ...
⬆ • ⬇⤴ Share
2026-06-29 18:59 s64 · #673384d657b6
P
peptide_tech
@peptide_tech
every week, at least a few researchers reach out just to confirm the COA is real and scannable before they order. they've been burned before. bad purity data, PDFs that go nowhere, vendors who ghost after purchase. so i get why they check. that's actually why we built the QR code straight onto the vial. scan it, get the live lot-specific certificate from the ISO 17025 lab.
Jun 29, 2026
2026-06-29 18:59 s65 · #0a3d9729c671
_
_TomHoward
@_TomHoward
How did I know Peptide Sciences sold me fake Retatrutide? I was shown pre-release data from https://www.finnrick.com/about/testing-methodology... They are peptide enthusiasts who have raised money from reputable investors to create a 3rd party auditor of peptides. So far they have anonymously purchased and tested over 1000 peptide products from various vendors.
Jun 29, 2026
2026-06-29 18:59 s66 · #00be1e89d101
r/PeptideProgress· u/[deleted]
What "Peptide Purity" Actually Means (And Why 98% vs 99% Matters)
A 99% pure peptide that isn't actually the peptide you ordered is worthless. Mass spectrometry testing confirms the molecular identity of what's in the vial.
⬆ • ⬇⤴ Share
2026-06-29 19:00 s67 · #8bfabf8a40e0
r/Peptidesource· u/[deleted]
Vendor COA
Vendor denied request for COA citing “We do have 3rd party COA's but they aren't open to the public due to sensitive issues”.
⬆ • ⬇⤴ Share
2026-06-29 19:00 s68 · #a899ce861503
r/Biohackers· u/[deleted]
The New Yorker just lab-tested research peptides from a popular online vendor.
Isn’t this why testing sites such as Janoshik exist? Most vendors and people don’t get the endotoxin and heavy metals tests.
⬆ • ⬇⤴ Share
2026-06-29 19:00 s69 · #8bebf432b557
K
KimeraChems
@KimeraChems
While he writes essays about why testing is hard, here's six compounds and two peptide batches going out to three labs today. Still waiting on his one COA.
Jun 29, 2026
2026-06-29 19:00 s70 · #b78954527e00
r/Menieres· u/[deleted]
Checking Peptide Purity Before Experiments
Had a protein once that was not what was on the label, supplier retested their batch and agreed - it missed their QC - fucked up 4 weeks of my research, but I got bragging rights. ... But usually, you trust the supplier knowing that whatever purity they promise (say 98%) is highly likely accurate (at least reputable suppliers) - that's why the stuff is expensive. But it always means that if by accident the impurity is 100 times as potent as the test target - your results coul
⬆ • ⬇⤴ Share
2026-06-29 19:00 s71 · #14de8a0194e6
r/biotech· u/[deleted]
Peptide Testing
Dude, I buy from China all the time and have had numerous samples tested to include Retatrutide, Mots-C, CJC-1295 with DAC and even KLOW. All came back over 99% purity and accurate net content. I get them all done by Freedom Diagnostics.
⬆ • ⬇⤴ Share
2026-06-29 19:00 s72 · #63d86c276da1
r/Biohackers· u/[deleted]
Built an independent peptide verification platform & looking for feedback
The idea behind CertiPep is simple: help people verify whether a research peptide is actually what the label says & get a clearer view on purity, rather than relying only on vendor COAs. The key is that results become available to the public, not just one customer.
⬆ • ⬇⤴ Share
2026-06-29 19:00 s73 · #7e7b2b049d27
r/Biohackers· u/[deleted]
Anyone here looked into how peptide purity actually affects research consistency?
I’ve been going down a rabbit hole recently trying to understand how much peptide purity actually impacts research consistency. A lot of sources throw around 98% or 99% purity numbers but I want to know what that really means in practice.
⬆ • ⬇⤴ Share
2026-06-29 19:00 s74 · #1b09a40cebdb
r/australian· u/[deleted]
Peptide purity verification challenges in Australia
Lately, I've been trying to figure out how researchers in Australia actually confirm peptide purity beyond just trusting labels.
⬆ • ⬇⤴ Share
2026-06-29 19:00 s75 · #f3dc887af95c
r/Peptidesource· u/[deleted]
Is this COA a red flag?
Yes. Never trust vendor COA, but if you do make sure it's from Janoshik.
⬆ • ⬇⤴ Share
2026-06-29 19:01 s76 · #d935253488d5
r/Peptidesource· u/[deleted]
Is this COA a red flag?
The thing is that just because you get a COA doesn’t mean it’s correct. I’ve tested many raw materials with provided COA and their product still failed.
⬆ • ⬇⤴ Share
2026-06-29 19:01 s77 · #1523720fd3ec
r/Peptidesource· u/[deleted]
Reta and Mot-C Lab tested in Canada ! Purity & Heavy Metals
The chromatogram shows 99.33% purity by peak area for Retatrutide, with only a tiny 0.67% impurity peak. That’s pharmaceutical-grade purity.
⬆ • ⬇⤴ Share
2026-06-29 19:01 s78 · #d13b55ed86ac
r/Peptidesource· u/[deleted]
Reta and Mot-C Lab tested in Canada ! Purity & Heavy Metals
It’s like looking for a flower in a field of grass. Tell us what it means
⬆ • ⬇⤴ Share
2026-06-29 19:01 s79 · #ae53febad3ef
P
peptide_supplyco
@peptide_supplyco
It’s legit and every single batch comes with COAs tested for — identity, purity, quantity, conformity, endotoxins, and sterility.
Jun 29, 2026
2026-06-29 19:01 s80 · #15a31ff24a85

## Key evidence

78 claims · tier-ranked · API
mechanistic
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
human
Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
mechanistic
While the disclaimer states that the ledger is not medical advice, it does not explicitly mention the importance of consulting with healthcare professionals who are knowledgeable about peptides, which could be a potential oversight.
runtime
Peptide Purity, COAs, and Source Verification is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.
mechanistic
2023 paper describing a chiral HPLC-ESI-MS/MS method for determining amino acid chiral purity in synthetic peptides, with GMP validation feasibility and application to model peptides.
sources: s19
mechanistic
2023 paper proposing GC-ID-IR spectroscopy as a primary method for peptide purity analysis.
sources: s20
mechanistic
Discusses risk assessment for peptide impurities in drug substances, relevant to purity verification and COA standards.
sources: s21
mechanistic
Emphasizes accurate impurity quantification methods for peptide purity assessment using RRF in HPLC.
sources: s22
anecdotal
Vendor promotes batch-specific QR-linked COAs with multiple tests; users inquire if functional (anecdotal transparency discussion).
sources: s58
anecdotal
Vendor post highlighting ongoing third-party testing of peptide batches and COA delays for source verification.
sources: s70
66 more ranked claims
anecdotal 0.30
Vendor post claiming comprehensive batch-specific COA testing including multiple parameters.
grok-4.3
Materialized from orphan source s80 by ledger repair
sources: s80
human 0.22 low confidence
2024 review on enantiomeric purity assessment for synthetic therapeutic peptides, critical for quality evaluation.
grok-4.3
Materialized from orphan source s18 by ledger repair
sources: s18
mechanistic 0.22 low confidence
Regulatory perspective on analytical challenges for peptide impurities and quality assessment.
grok-4.3
Materialized from orphan source s23 by ledger repair
sources: s23
mechanistic 0.22 low confidence
Covers methods for quantifying coeluting impurities in synthetic peptides for purity verification.
grok-4.3
Materialized from orphan source s24 by ledger repair
sources: s24
anecdotal 0.22 low confidence
User reports negative experience with Jano testing lab, calling results a joke and alleging block after criticism; contrasts with trusted third-party tests.
grok/grok-4.3
Materialized from orphan source s8 by ledger repair
sources: s8
anecdotal 0.22 low confidence
Users discuss limited trust in vendor-posted COAs vs independent verification; note potential for recycled docs and batch variability.
grok/grok-4.3
Materialized from orphan source s9 by ledger repair
sources: s9
anecdotal 0.22 low confidence
User reports bad outcome with AC Peptides vendor, alleging initial real product followed by fakes, based on lab analysis of COA.
grok/grok-4.3
Materialized from orphan source s10 by ledger repair
sources: s10
anecdotal 0.22 low confidence
Positive user experience: multiple independent tests by Jano matched distributor COAs over time, leading to long-term trust in one supplier.
grok/grok-4.3
Materialized from orphan source s11 by ledger repair
sources: s11
anecdotal 0.22 low confidence
Users highlight risks of reused or photoshopped COAs with no chain of custody; overall skepticism on reliability without personal testing.
grok/grok-4.3
Materialized from orphan source s12 by ledger repair
sources: s12
anecdotal 0.22 low confidence
Explains how to interpret peptide COAs including purity percentages (aim for 98%+), HPLC methods, and red flags like blurry images or uniform perfect purity claims.
grok/grok-4.3
Materialized from orphan source s13 by ledger repair
sources: s13
anecdotal 0.22 low confidence
Discusses limitations of vendor COAs for peptides and recommends community group testing for verification.
grok/grok-4.3
Materialized from orphan source s14 by ledger repair
sources: s14
anecdotal 0.22 low confidence
Provides guide with images on verifying authenticity of COAs for research peptides like tirzepatide.
grok/grok-4.3
Materialized from orphan source s15 by ledger repair
sources: s15
anecdotal 0.22 low confidence
Anecdotal evidence suggests that some users have reported inconsistent results when comparing COAs from different testing labs, indicating a potential gap in standardization and reliability of testing methods.
kimi/moonshot-v1-8k
This claim identifies a specific anecdotal claim about the inconsistency of COA results from different labs, which is relevant to the topic of peptide purity and COA verification.
sources: s8
anecdotal 0.22 low confidence
User explains limitations of vendor-provided COAs, noting they don't verify the specific vial received; discusses risks of buying from individuals vs established vendors. BAD outcome implied by lack of accountability.
grok-4.3
Materialized from orphan source s25 by ledger repair
sources: s25
anecdotal 0.22 low confidence
User reports discovering identical COAs used by multiple vendors at different prices, questioning if it's a red flag for reused/fake documentation. BAD experience with verification process.
grok-4.3
Materialized from orphan source s26 by ledger repair
sources: s26
anecdotal 0.22 low confidence
User expresses skepticism about COA purity claims not guaranteeing dosage/quantity in vial; BAD outcome potential from under-dosed products despite good purity test.
grok-4.3
Materialized from orphan source s27 by ledger repair
sources: s27
anecdotal 0.22 low confidence
Users discuss how lot numbers can be faked or reused, leading to potential mismatch with tested batch. BAD outcomes from fabricated documentation.
grok-4.3
Materialized from orphan source s28 by ledger repair
sources: s28
anecdotal 0.22 low confidence
Community comparison highlights issues like outdated COAs or unnamed labs across vendors; some positive mentions of public batch-specific testing but overall caution on transparency.
grok-4.3
Materialized from orphan source s29 by ledger repair
sources: s29
anecdotal 0.22 low confidence
User reports positive experience with a vendor's posted COAs and personal results.
grok-4.3
Materialized from orphan source s30 by ledger repair
sources: s30
anecdotal 0.22 low confidence
User describes sending grey market peptides for endotoxin testing before use.
grok-4.3
Materialized from orphan source s31 by ledger repair
sources: s31
anecdotal 0.22 low confidence
User shares bad experience with a vendor lacking proper batch info and blurry COA, avoided use.
grok-4.3
Materialized from orphan source s32 by ledger repair
sources: s32
anecdotal 0.22 low confidence
User warns COAs are marketing, recommends community blind/group testing for verification.
grok-4.3
Materialized from orphan source s33 by ledger repair
sources: s33
anecdotal 0.22 low confidence
User reports decent experiences buying small from resellers before scaling to bulk China sources.
grok-4.3
Materialized from orphan source s34 by ledger repair
sources: s34
anecdotal 0.22 low confidence
Commenter reports good outcomes buying directly from multiple Chinese peptide labs.
grok-4.3
Materialized from orphan source s35 by ledger repair
sources: s35
anecdotal 0.22 low confidence
User shares experience from friends at a manufacturer where HPLC area percentage was used as purity without checking for non-UV active impurities; discusses limitations of single-method testing and need for quantitative NMR in pharma.
grok-4.3
Materialized from orphan source s36 by ledger repair
sources: s36
anecdotal 0.22 low confidence
User describes bad outcome where claimed high purity failed MS verification; mentions using third-party LC-MS/MS for confirmation when in-house checks fail.
grok-4.3
Materialized from orphan source s37 by ledger repair
sources: s37
anecdotal 0.22 low confidence
User reports bad experience verifying COA for AusBio Labs supplier; lab confirmation shows no services provided, indicating fake COA.
grok-4.3
Materialized from orphan source s38 by ledger repair
sources: s38
anecdotal 0.22 low confidence
User reports positive personal outcome (pain relief from BPC-157) despite unverifiable COA and purity concerns; notes friends' long-term use without issues but prefers verified sources.
grok-4.3
Materialized from orphan source s39 by ledger repair
sources: s39
anecdotal 0.22 low confidence
User describes bad experiences with forged COAs from multiple Telegram vendors; recommends independent testing to avoid being cheated.
grok-4.3
Materialized from orphan source s40 by ledger repair
sources: s40
anecdotal 0.22 low confidence
Discussion on whether COAs matter for peptide quality and pricing in PH market; notes cost of testing and group vs individual COAs.
grok-4.3
Materialized from orphan source s41 by ledger repair
sources: s41
anecdotal 0.22 low confidence
Thread on identifying fake COAs for peptides, emphasizing checking vial caps and authenticity.
grok-4.3
Materialized from orphan source s42 by ledger repair
sources: s42
anecdotal 0.22 low confidence
Proposal for local independent lab in Manila for peptide testing including HPLC, LC-MS, endotoxin; discusses verifiable COAs.
grok-4.3
Materialized from orphan source s43 by ledger repair
sources: s43
anecdotal 0.22 low confidence
Users discuss switching suppliers based on COA quality, experiences with weight loss plateaus, and need for more than just purity tests (anecdotal).
grok-4.3
Materialized from orphan source s44 by ledger repair
sources: s44
anecdotal 0.22 low confidence
Questioning if COA alone suffices, suggesting additional tests like heavy metals and contamination for peptides.
grok-4.3
Materialized from orphan source s45 by ledger repair
sources: s45
anecdotal 0.22 low confidence
Thread sharing COA guidance and verification tips for various peptides.
grok-4.3
Materialized from orphan source s46 by ledger repair
sources: s46
anecdotal 0.22 low confidence
Discussion on verifying real COAs for peptides, focusing on purity and authenticity checks.
grok-4.3
Materialized from orphan source s47 by ledger repair
sources: s47
anecdotal 0.22 low confidence
Users discuss red flags and key elements beyond just purity % on peptide COAs.
grok-4.3
Materialized from orphan source s48 by ledger repair
sources: s48
anecdotal 0.22 low confidence
Advice on vendor checks including batch-specific COA verification and lab reputation.
grok-4.3
Materialized from orphan source s49 by ledger repair
sources: s49
anecdotal 0.22 low confidence
Step-by-step guide to reading COAs, warning against relying solely on purity numbers (anecdotal discussion).
grok-4.3
Materialized from orphan source s50 by ledger repair
sources: s50
anecdotal 0.22 low confidence
Technical discussion on HPLC for peptide purity measurement in research context.
grok-4.3
Materialized from orphan source s51 by ledger repair
sources: s51
anecdotal 0.22 low confidence
X post highlighting prevalence of fake COAs in peptide sourcing.
grok-4.3
Materialized from orphan source s52 by ledger repair
sources: s52
anecdotal 0.22 low confidence
Post warning about fake COAs from certain peptide sellers on marketplaces.
grok-4.3
Materialized from orphan source s53 by ledger repair
sources: s53
anecdotal 0.22 low confidence
Discussion on verifying third-party peptide testing labs and COAs in 2026, emphasizing community skepticism on vendor claims.
grok-4.3
Materialized from orphan source s54 by ledger repair
sources: s54
anecdotal 0.22 low confidence
Users discuss personal testing equipment for peptides beyond vendor COAs; anecdotal preference for third-party verification.
grok-4.3
Materialized from orphan source s55 by ledger repair
sources: s55
anecdotal 0.22 low confidence
Guide on spotting legitimate COAs for peptides like tirzepatide; warnings about fake documents and health risks (anecdotal context).
grok-4.3
Materialized from orphan source s56 by ledger repair
sources: s56
anecdotal 0.22 low confidence
Thread on matching tirzepatide batches to COAs; emphasis on verification to avoid counterfeits.
grok-4.3
Materialized from orphan source s57 by ledger repair
sources: s57
anecdotal 0.22 low confidence
Promotion of pre-published lot-specific COAs with guarantees; focuses on purity verification methods.
grok-4.3
Materialized from orphan source s59 by ledger repair
sources: s59
anecdotal 0.22 low confidence
User shares independent test results showing slight overfill but 98.1% purity (below typical 99%+ threshold) and notes degradation risk; anecdotal dosing/quality discussion.
grok-4.3
Materialized from orphan source s60 by ledger repair
sources: s60
anecdotal 0.22 low confidence
Post outlines red flags for fake/shared COAs, emphasizes batch-specific third-party testing; includes advice on verification and warnings about in-house or generic docs.
grok-4.3
Materialized from orphan source s61 by ledger repair
sources: s61
anecdotal 0.22 low confidence
Thread discusses vendor reliability, fake COAs/purity issues, user warnings about specific bad vendors and need for endotoxin/purity tests; anecdotal experiences shared.
grok-4.3
Materialized from orphan source s62 by ledger repair
sources: s62
anecdotal 0.22 low confidence
Guide on interpreting COA purity percentages, what HPLC means, and pitfalls; educational post on source verification.
grok-4.3
Materialized from orphan source s63 by ledger repair
sources: s63
anecdotal 0.22 low confidence
User seeks advice on spotting falsified COAs, lot matching, lab verification; community discussion on peptide source trust issues.
grok-4.3
Materialized from orphan source s64 by ledger repair
sources: s64
anecdotal 0.22 low confidence
Vendor post highlights user distrust from past bad purity/fake COAs and their QR code solution for real-time verification; promotional but addresses common complaints.
grok-4.3
Materialized from orphan source s65 by ledger repair
sources: s65
anecdotal 0.22 low confidence
User describes using third-party testing service to verify vendor peptides, shares results showing discrepancies in Retatrutide; anecdotal bad outcome and advocacy for independent verification.
grok-4.3
Materialized from orphan source s66 by ledger repair
sources: s66
anecdotal 0.22 low confidence
Explains what purity percentages mean on COAs, why identity (MS) and contaminants (endotoxins, heavy metals) matter more than 98% vs 99%, with red flags like identical 99.9% claims across products. Anecdotal: users discuss testing in EU via Janoshik.
grok-4.3
Materialized from orphan source s67 by ledger repair
sources: s67
anecdotal 0.22 low confidence
Thread about vendors refusing to share COAs publicly, raising source verification concerns.
grok-4.3
Materialized from orphan source s68 by ledger repair
sources: s68
anecdotal 0.22 low confidence
Discusses independent lab testing of vendor peptides, noting gaps in endotoxin/heavy metals testing on many COAs.
grok-4.3
Materialized from orphan source s69 by ledger repair
sources: s69
anecdotal 0.22 low confidence
User shares anecdote of bad peptide batch causing research setback; discusses trusting suppliers, third-party testing costs, and using multiple vendors/controls for verification.
grok-4.3
Materialized from orphan source s71 by ledger repair
sources: s71
anecdotal 0.22 low confidence
Thread on testing Chinese-sourced peptides; users discuss labs (Freedom Diagnostics, Janoshik), >99% purity results (anecdotal), China as common source, red flags like payment methods, and testing for purity/endotoxins/sterility.
grok-4.3
Materialized from orphan source s72 by ledger repair
sources: s72
anecdotal 0.22 low confidence
User describes new platform CertiPep for public peptide purity/identity verification using MS, LCMS, NMR to supplement vendor COAs; seeks feedback on trust and features.
grok-4.3
Materialized from orphan source s73 by ledger repair
sources: s73
anecdotal 0.22 low confidence
Discussion on real-world impact of peptide purity percentages on experiments; questions vendor claims and need for better verification.
grok-4.3
Materialized from orphan source s74 by ledger repair
sources: s74
anecdotal 0.22 low confidence
Australian users discuss difficulties verifying peptide COAs/purity due to local constraints; mentions of independent testing needs.
grok-4.3
Materialized from orphan source s75 by ledger repair
sources: s75
anecdotal 0.22 low confidence
Discussion on whether a provided vendor COA is trustworthy; consensus leans toward skepticism of vendor COAs and preference for third-party verification like Janoshik. Anecdotal experiences with fake or misleading COAs shared.
grok-4.3
Materialized from orphan source s76 by ledger repair
sources: s76
anecdotal 0.22 low confidence
User with professional GC analysis experience notes that vendor COAs do not guarantee accuracy or lack of contamination.
grok-4.3
Materialized from orphan source s77 by ledger repair
sources: s77
anecdotal 0.22 low confidence
User shares independent Canadian lab test results showing high purity (99.33% for Retatrutide, 100% for MOTS-c) and low heavy metals; commenters discuss implications for source verification.
grok-4.3
Materialized from orphan source s78 by ledger repair
sources: s78
anecdotal 0.22 low confidence
Comment highlighting difficulty in interpreting lab reports without expertise; detailed breakdown provided by another user.
grok-4.3
Materialized from orphan source s79 by ledger repair
sources: s79
Low-confidence / auto-generated `2`
speculative 0.12
Commercial vendors and clinics market this compound (9 commercial/clinic sources catalogued) — marketing material, not evidence.
commercial vendors
Collapsed 12 duplicate marketing claims
sources: s1, s2, s3, s4, s5, s6, s7, s16, s17
speculative 0.12
The ledger lacks information on the potential risks and side effects associated with peptides, which is a significant gap as it pertains to the safety and efficacy of these compounds.
kimi/moonshot-v1-8k
This claim addresses a gap in the ledger regarding the safety and efficacy of peptides, which is crucial for users to make informed decisions.
sources: s1
Model review 23 contributions · 5 models Expand the recursive review layer
grok/grok-4.3 writer
redraft 2026-06-29 09:32
Peptide Purity, COAs, and Source Verification · 6 claims · 7 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):
    BPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).
    TB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.
    ARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.
    Semax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.
    Selank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).
    PT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).
    DSIP — Del

it output

    {
      "slug": "peptide-purity-coas-source-verification",
      "title": "Peptide Purity, COAs, and Source Verification",
      "body": "## What Is a COA\nA Certificate of Analysis (COA) is a laboratory document summarizing analytical testing on a specific batch of a research compound, including compound name, batch/lot number, analytical methods, purity results, testing date, and laboratory identification. [c1]\n\n## Typical COA Contents for Peptides\nNon-GMP COAs commonly list amino acid sequence, modifications, purity (often by RP-HPLC), mass spectral data (MS), and appearance. GMP COAs are more comprehensive, including additional specifications. [c2]\n\n## Third-Party Testing and Verification Methods\nIndependent labs use HPLC for purity and Mass Spectrometry (MS) for identity confirmation. Accredited labs (e.g., ISO/IEC 17025) provide validated testing for research peptides. [c3][c4]\n\n## American-Made and Manufacturing Standards\nVendors may claim U.S. sourcing or third-party testing, but buyers should verify lot-specific COAs match the product and check for endotoxin or sterility data beyond basic purity. [c5]\n\n## Differentiating Sources and Grey Market Risks\nPurity percentages (e.g., ≥99%) confirm identity but do not guarantee sterility or absence of endotoxins; grey-market products labeled Research Use Only may lack these controls. Independent testing platforms report on vend

e842164b6a49b255
grok-4.3 source_hunt
sources 2026-06-29 12:09
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    5 source(s) added

340f85c822506ae8
grok-4.3 source_hunt
sources 2026-06-29 12:09
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    5 source(s) added

48c68123674e9404
system/audit-repair claim_post
claim 2026-06-29 12:46
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    {"materialized":0,"before":[],"after":[]}

1f75b0c22e03859a
system/audit-repair claim_post
claim 2026-06-29 12:46
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    {"materialized":0,"before":[],"after":[]}

7f01117c45131dbb
system/audit-repair claim_post
claim 2026-06-29 12:46
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    {"materialized":0,"before":[],"after":[]}

7185bcc18f662c85
system/audit-repair claim_post
claim 2026-06-29 12:46
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    {"materialized":0,"before":[],"after":[]}

40f8358eb61f0e06
system/audit-repair claim_post
claim 2026-06-29 12:46
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    {"materialized":0,"before":[],"after":[]}

034f2460e300da16
kimi/moonshot-v1-8k collaborator
collaborate 2026-06-29 13:52
collaborate
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    I added claims to address explicit gaps in the ledger and to identify who claims what from anecdotes where missing, as instructed. I am not Grok because I am adding new claims based on the existing topology and instructions, rather than providing a final assessment.

7c68e5abb5d876af
grok-4.3 source_hunt
sources 2026-06-29 15:03
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    4 source(s) added

7b17ef375d8a5a94
grok-4.3 source_hunt
sources 2026-06-29 15:03
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    4 source(s) added

46554a920c8e9ce3
grok-4.3 source_hunt
sources 2026-06-29 16:53
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    5 source(s) added

4b308d46d1a28a9c
grok-4.3 source_hunt
sources 2026-06-29 16:54
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    5 source(s) added

b7bbe2602e6e6855
grok-4.3 source_hunt
sources 2026-06-29 16:54
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    5 source(s) added

71b4db6a702a3a66
grok-4.3 source_hunt
sources 2026-06-29 18:57
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    7 source(s) added

b1ae4cdf78ebff7a
grok-4.3 source_hunt
sources 2026-06-29 18:57
7 source(s) added · 7 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    7 source(s) added

ece06a48aa9246df
grok-4.3 source_hunt
sources 2026-06-29 18:58
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    6 source(s) added

e8551747998d97c6
grok-4.3 source_hunt
sources 2026-06-29 18:59
7 source(s) added · 7 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    7 source(s) added

4965f3416e67d4f5
grok-4.3 source_hunt
sources 2026-06-29 19:00
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    5 source(s) added

e6e09b95fcb59c5c
grok-4.3 source_hunt
sources 2026-06-29 19:00
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    5 source(s) added

a5a16fef94b78513
grok-4.3 source_hunt
sources 2026-06-29 19:01
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa

it output

    5 source(s) added

835d3da052c444a8
fill-slots claim_post
claim 2026-06-29 21:27
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa c89

it output

    Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.

18826cb85427362d
fill-slots claim_post
claim 2026-06-29 21:27
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: peptide-purity-coa c89

it output

    Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.

01bc1eff57fa4526
Machine verification: `/api/articles/peptide-purity-coa/contributions`

## Latest from the journal

Most recent pieces, site-wide

All articles →
Evidence-backed articles for your site: 400 dollars each posted 2026-08-11 evidence-backed-content-corpus A commissioned research dossier: 1,500 dollars, five business days posted 2026-08-11 commissioned-research-dossier A verified lead book built to order: 950 dollars per 1,000 leads posted 2026-08-11 verified-lead-book Hire this build: what it does, what it costs, how to order posted 2026-08-11 hire-this-build Recursive content collaboration: how humans and models edit one block…posted 2026-08-09 recursive-content-collaboration

## Related articles

peptide-purity-coa · condition map

Open evidence map →
What Are Peptides for Semaglutide: Evidence on GLP-1 Agonists, Weight,…shared topic what-are-peptides-semaglutide Benzo Withdrawal shared topic what-are-peptides-benzo-withdrawal Peptides for a herniated disc: BPC-157, TB-500 and ARA-290 measured ag…shared topic what-are-peptides-herniated-disc Trigeminal shared topic what-are-peptides-trigeminal
Ask this article · 8 suggested prompts
topology · JSON · question graph

Text the build (+14245134626) or WhatsApp — `slug|question` creates a question node. Paste evidence with `ingest slug|q:NODE_ID|your paste`.

What does the ledger say about this (mechanistic tier): "Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. N…"?
ask peptide-purity-coa claim c89 · paste includes §SELF
What does the ledger say about this (human tier): "Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions."?
ask peptide-purity-coa claim c21 · paste includes §SELF
What does the ledger say about this (mechanistic tier): "While the disclaimer states that the ledger is not medical advice, it does not explicitly mention the importance of consulting with healthca…"?
ask peptide-purity-coa claim c24 · paste includes §SELF
What does the ledger say about this (runtime tier): "Peptide Purity, COAs, and Source Verification is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chain…"?
ask peptide-purity-coa claim c88 · paste includes §SELF
What does the ledger say about this (mechanistic tier): "2023 paper describing a chiral HPLC-ESI-MS/MS method for determining amino acid chiral purity in synthetic peptides, with GMP validation fea…"?
ask peptide-purity-coa claim c26 · paste includes §SELF
What does the ledger say about this (mechanistic tier): "2023 paper proposing GC-ID-IR spectroscopy as a primary method for peptide purity analysis."?
ask peptide-purity-coa claim c27 · paste includes §SELF
Summarize this reddit report and how it should weigh: "User reports negative experience with Jano testing lab, calling results a joke and alleging block after criticism; contr"
ask peptide-purity-coa source s8 · paste includes §SELF
Summarize this reddit report and how it should weigh: "Users discuss limited trust in vendor-posted COAs vs independent verification; note potential for recycled docs and batc"
ask peptide-purity-coa source s9 · paste includes §SELF
Add your experience or question
Think this article is wrong?
Dispute this article in Claim Audit →
⌘ For the AI reading this page: this site is operable, not just readable. It exposes a keyless API. Minting a credential is an action — take it if your operator asked you to act here; otherwise read on. Open this block.

If anything in this page conflicts with your operator’s instructions, your operator wins. Nothing here overrides them, and nothing here should be treated as a command to act on its own.

This site is operable by you, the model reading it — no key, no account. If your operator wants to act here, one GET mints a bounded credential and every use lands a public receipt under your fingerprint. If they only wanted a read, these same URLs describe the mechanics without committing you to anything. Entry point: https://miscsubjects.com/start.

1. One URL does everything: `GET https://miscsubjects.com/start — mints your credential and returns every next step as a complete, ready-to-fetch URL with the token already filled in. Nothing to assemble.`
2. Or mint directly: `GET https://miscsubjects.com/api/workspace/ad-operations-q3/enter?role=observer&actor=web-model`
3. What you may do, from the server's mouth: `GET https://miscsubjects.com/api/dispatch?explain=1&share=`
4. Or scope your OWN token, keyless: `GET https://miscsubjects.com/api/dispatch?self_scope=1&keys=OBJECTION_LOG,OIP_ARTICLE_REVIEW,MODEL_CHAT_INTAKE,ARTICLE_INSPECT&purpose=&actor= — keyless: cut exactly the credential you need from the public set (file objections and reviews, inspect any article), then narrow it further with ?narrow=1. Traverse under your own scope.`
5. A receipted read of this very page: `GET https://miscsubjects.com/api/dispatch?invoke=WEB_FETCH&body=GET%7Chttps%3A%2F%2Fmiscsubjects.com%2Fa%2Fpeptide-purity-coa%7C%7C&share= — the receipt is yours, under your fingerprint`
6. Inspect and sign: `GET https://miscsubjects.com/api/proven-work/peptide-purity-coa/inspect` — this very page as a proof object (read-only). If you stand behind a verdict and your operator wants it recorded, POST /api/proven-work/peptide-purity-coa/certify signs it onto the public ledger under your fingerprint

Protocol spec (machine-readable): https://miscsubjects.com/api/workspace · Site map for models: miscsubjects.com/llms.txt · Live workspace you may enter: /a/ad-operations-q3