Evidence review

# Selank: one 62-patient trial against a benzodiazepine, and 40 people counted

Posted Jun 29, 2026 · Updated Aug 4, 2026 · 15 min read
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    ## §SELF — miscsubjects portable reference

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Selank is a seven-amino-acid peptide developed in Moscow and approved in Russia in 2009 for generalised anxiety disorder. There is one controlled trial in people that carries almost the whole case: 62 patients, 30 given Selank and 32 given a benzodiazepine, published in 2008. It found the anxiety relief comparable and, unlike the benzodiazepine, no sedation, no muscle slackening, no tolerance and no withdrawal. Two smaller Russian studies followed, one of them showing the calm outlasting the last dose by a week. Nothing of that size or better has been run in the West, and the animal work points to something the sales pages leave out: in mice, the effect showed up only in the strain that was anxious to begin with.

The site you are reading this on is funded by a business that sells this peptide. That is a commercial interest, and it is why the trial sizes below are given as numbers rather than as the phrase "clinically studied".

## Two peptides fused: an immune signal with a protection tail

The sequence is Thr-Lys-Pro-Arg-Pro-Gly-Pro. The first four letters are tuftsin, a fragment your own body cuts out of an antibody. Tuftsin's day job has nothing to do with anxiety: it tells the cells that swallow bacteria to get on with it. The last three letters — proline, glycine, proline — are a chemical tail that stops enzymes in the blood from chewing the molecule up in seconds.

So Selank is an immune peptide with a stability tail bolted on. That construction explains something that otherwise looks like marketing overreach. When you read that this compound both calms anxiety and changes immune signalling, that is not two claims stacked to sell a product. It is one molecule that came out of an immune fragment, and both halves have been measured.

## The 62-patient trial that is the whole human case

Sixty-two patients with generalised anxiety disorder and neurasthenia — a diagnosis still used in Russian practice for exhaustion with anxiety — were split into two groups. Thirty received Selank. Thirty-two received medazepam, a benzodiazepine. The published result: Selank produced clear anxiety relief and a mild improvement in thinking, and did it without the side effects that come as standard with that drug class. The paper names them: sedation, muscle relaxation, tolerance building, and a withdrawal syndrome on stopping.

That comparison is the reason anyone outside Russia has heard of this compound, so it is worth being precise about what it is and is not. Thirty patients in the Selank arm is small. The comparison was against an active drug rather than a placebo, which tests whether it matches medazepam and not whether it beats nothing. And it was published in a Russian journal in 2008 and has never been repeated by an independent group in another country.

Two further Russian studies fill in around it. One compared Selank against phenazepam, another benzodiazepine, in anxiety disorders: it again found clear anxiety relief with a mild thinking benefit, and reported something the benzodiazepine comparison does not produce — the calm lasted a week after the last dose. A conference report on treatment response found 40 per cent of patients were fast responders, with the whole set of symptoms dropping inside the first one to three days.

You will also see two figures quoted on clinic pages that the primary papers here do not support: a "70 per cent reduction in anxiety scores", and a claim that Selank completed Phase III trials. Neither traces to a paper in the set of sources attached to this page. Treat both as marketing until someone produces the document.

## The follow-up nobody quotes: adding it to a tranquilliser cut the tranquilliser's side effects

The most practically interesting human study is the one that gets left out of every summary. Patients on phenazepam had Selank added. The tranquilliser's benefit arrived sooner, and the list of problems it causes got smaller — the paper names attention and memory trouble, weakness, sedation, sleeping too long, sexual problems, emotional flatness and dizziness on standing — both during the course and after the tranquilliser was stopped.

If that result holds up, the useful role is not as a replacement for an anxiety drug but as something given alongside one, particularly through the part where the drug is being withdrawn. That is also the use the self-reported record circles back to again and again, which is unusual: the people buying it online and the Russian clinical literature have independently landed in the same place.

## It works alongside GABA instead of docking where the sedatives dock

GABA is the brain's main calming signal. Benzodiazepines work by grabbing a specific spot on the GABA-A receptor and making the receptor respond harder to the GABA already there. That mechanism is also why they sedate, why tolerance builds, and why stopping them is dangerous.

Selank does not do that. When rats were given Selank, 45 genes involved in nerve signalling changed how much they were switched on at one hour, and 22 were still changed at three hours. The pattern the authors found looked like an indirect change to the GABA system rather than a direct grab at the receptor — the peptide alters the machinery around the signal instead of jamming the switch.

That distinction is the whole explanation for the reported side-effect profile. A drug that does not lock onto the sedative site should not sedate, should not build tolerance in the classic way, and should not produce a withdrawal syndrome. The 2008 trial reported exactly that. It is the rare case where the mechanism and the clinical observation agree without anyone having to stretch.

A related human study looked at whole-brain connections at rest in 52 healthy participants given Selank or Semax and mapped where each changed the pattern. That study measures brain signalling, not how anybody felt.

## The mouse result that predicts who it will do nothing for

One study compared Selank given into the nose against Selank injected into the belly in two strains of mouse: BALB/c, which are naturally anxious and explore less, and C57BL/6, which are not. Both routes worked — and only in BALB/c.

Read that again, because it is the single most useful line in the animal literature for anyone deciding whether to bother. The anxiety effect appeared only in animals that were anxious to start with. In the calm strain, either route did nothing.

That finding predicts the shape of the self-reported record below with uncomfortable accuracy. People who describe crippling social anxiety or panic report dramatic responses. People who describe themselves as already fairly calm and taking it for focus report nothing at all. The mouse data says that is not two groups disagreeing about a drug; it is the same drug doing what it does, which is to bring a raised anxiety level down rather than to push a normal one lower.

## Withdrawal is where the animal numbers are strongest

The most specific numbers in the whole Selank literature come from withdrawal models, not anxiety models.

In morphine-dependent rats, a single injection at 0.3 milligrams per kilogram cut the total withdrawal score by 39.6 per cent, with a p-value under 0.0001. It reduced convulsive reactions, drooping eyelids and posture problems, and it raised the touch-sensitivity threshold nine-fold — meaning the animals stopped reacting to light contact that had become painful.

In rats withdrawing from alcohol, the same single 0.3 milligram-per-kilogram dose removed the anxiety that withdrawal produced.

In rats given alcohol long-term, 0.3 milligrams per kilogram daily for seven days protected against the memory damage, and the mechanism traced through BDNF — the growth factor nerve cells use to build and repair connections — staying up in the hippocampus and prefrontal cortex. The same dose improved thinking in nine-month-old rats that had never been given alcohol.

Under chronic mild stress, Selank on its own reduced raised anxiety more effectively than diazepam did, and the two together were tested in the same experiment.

That heightened touch sensitivity in the morphine study is the closest thing in this literature to a pain finding, and it is worth being blunt about how far it reaches: it is a withdrawal-driven sensitivity measured in rats, and no human study of Selank has measured pain of any kind.

## The immune side, which is the half nobody sells

Because the molecule starts as an immune fragment, the immune measurements are not a side note.

Under social stress in animals, Selank brought four inflammatory messengers down to near-normal levels: IL-1β, IL-6, TNF-α and TGF-β1. Those are the same signals that run high in chronic inflammation anywhere in the body.

In people, one study measured these signals in patients with anxiety combined with exhaustion, and the authors concluded the peptide changed the signalling pattern enough to be worth studying as an immune-acting drug in that group.

This is a small evidence base and it is pointing somewhere real. It is also the part of the story that gets dropped when the compound is sold as a calm-focus spray, which is a shame, because the inflammation numbers are more specific than most of the anxiety numbers.

## Where it flatly failed

In a rat model of Parkinson's disease made by destroying dopamine neurons with 6-OHDA, neither Selank nor Semax changed movement activity, and neither changed the animals' passive defensive behaviour. That is a clean negative in a model where BDNF-raising compounds are often assumed to help.

One evidence-rating service scores Selank 34 out of 100 and grades it D+, citing limited validation outside Russia. A clinical question-and-answer service concludes it should not be used off-label for mild-to-moderate anxiety in adults because it is not FDA-approved and the data are insufficient. Both of those are judgements rather than measurements, and both are fair readings of a file whose best trial has 30 people in the treatment arm.

## Forty people wrote down what happened, and the direction is one-sided

Sixty self-reported sources were collected for this page from Reddit, X, YouTube, Instagram and a bodybuilding forum. Twenty of them are guides, product descriptions, vendor answers, dosing questions or general commentary with no personal outcome, so they are not counted. Forty describe what happened to a specific person.

Of those 40: 27 reported a benefit, 6 reported a benefit that came with a cost, 3 reported nothing at all, and 4 reported harm.

Nobody was blinded and nobody was randomised. People who feel transformed post more than people who feel nothing. A large share of accounts describe taking Selank together with Semax, which makes attributing any single effect to one of them unreliable. With all that said, this is a lopsided record — roughly two in three clear benefit — and the direction is worth reporting, because it is more one-sided than the record for most compounds documented on this site.

### The 27 who said it worked, and what they say it feels like

The descriptions are unusually consistent, and they are not descriptions of sedation.

"It's not like benzos where anxiety just melts — it's more like... I feel like myself. Actually myself. Calm, thoughts coming easily, work just flows." That report, from day three, captures the register of most of the others.

Social anxiety is the strongest cluster. One person, after a single dose: "I finally am free from social anxiety... I easily hold eye contact and can make small talk no problem." Another, on nasal spray for a few days, described it easing social pressure while keeping them focused. A third reported it made their son social while doing nothing for them at the same dose from the same vial.

The subtle version matters as much as the dramatic one. "It doesn't feel like anything. But then I compare my behaviours from a week of taking it compared to before, and I'm a lot less" — the sentence continues into the details of what they stopped doing. Someone measuring stress with a wearable ring reported it reading calm after dosing three hours before bed.

Withdrawal comes up repeatedly and unprompted, matching the Russian clinical work. One person coming off benzodiazepines: "Selank took away all the anxiety, my memory got better. I was able to taper faster." Another, on 1,000 micrograms a day under the skin, reported it helped long-running insomnia and body pains from pregabalin withdrawal. One person reported it settling both IBS symptoms and generalised anxiety by day five, which is the only report here touching the gut.

Sleep shows up as a second-order effect rather than a sedative one: "it calms all the mental noise and allows me to rest better without my mind racing when I go to bed." One person rated their deep sleep "off the charts" at 8 out of 10 after initially noticing nothing.

The strongest single account is a person with long-standing numbness who took 250 micrograms into the nose and described feeling better within five minutes and crying with relief an hour later. One account is that stark and it is one account.

### The 6 who got a result with a cost attached

Fading and tolerance is the main cost. One person on 600 micrograms into the nose daily described exactly the effect they wanted — easier conversation, relaxed but not tired — and then: it does not last long enough, and they felt tolerance building. Another, injecting both Selank and Semax daily, watched the effect erode until 2 milligrams of each did nothing, took a break, and reported it hit like the first time on restarting.

One report is a benefit the person could not keep: "Selank is amazing for me but I cannot tolerate it." One is a benefit shadowed by a specific warning: solid effects, increased focus, and advice to stop immediately at any sign of hair loss. One person noticed nothing except better sleep, then found their REM sleep dropped from 25 per cent to 13 per cent on the days they skipped it, and stopped over that. One first dose of 100 micrograms felt stimulating rather than calming — "it almost felt like I had a hit of coke. I was tweaking a bit."

### The 3 who felt nothing — and the pattern they share with the mouse data

Three accounts report no effect. One used a nasal spray four or five times in a week and asked whether they had bought a placebo. One found four weeks of nasal use not worth cycling again. One got nothing at the same dose that worked for their son.

Every one of those three was chasing focus, calm on demand, or a general upgrade rather than treating a diagnosed anxiety problem. That is the BALB/c and C57BL/6 result showing up in people: the compound moves a raised anxiety level and appears to do very little to a normal one.

### The 4 who got worse, including two who got the opposite of the advertised effect

Two reports are the reverse of the intended effect. One person described a paradoxical reaction — sleep collapsing to 4 or 5 a.m., only a few hours of it, and anxiety getting worse at the same time. One person taking it for PTSD reported extreme paranoia and anxiety, and noted in the same post that their brother used it with great benefit.

Two are mood and sedation. One reported a mood drop from day two that deepened into depression over days, with withdrawal from other people. One, stacking it with Semax and another compound, reported sedation, thinking problems and depressive symptoms — the exact three effects the 2008 trial reported as absent.

Four harm reports out of 40 is not a rate; it is four accounts. But their content is specific and it contradicts the cleanest part of the trial data, so it belongs at the same size as the good news. A person with PTSD or a trauma history has a documented reason here to start at the bottom of the dose range.

## Doses people use, nose against needle, and the sleep timing

The Russian studies used a nasal solution; the animal work used 0.3 milligrams per kilogram into the belly, which does not convert cleanly to a human dose.

What people report using: 100 to 600 micrograms into the nose per dose, or 250 micrograms to 1 milligram a day under the skin. One person runs 500 micrograms three days a week rather than daily. Several dose in the evening deliberately, one to two hours before bed, on the grounds that the effect is calm rather than stimulation. One person's report of a stimulant-like reaction at 100 micrograms is the argument for starting low regardless of what the rest of the record says.

The duration reports cluster short: about three hours of clear effect from a dose, on top of a background change that several people say only becomes visible after a week when they look back at their own behaviour.

## Amidate, Adalank and the modified versions being sold as upgrades

Several products in circulation are not Selank. N-acetyl Selank amidate has chemical caps on both ends to slow breakdown. Adalank is described by its sellers as a modified Selank with two changes intended to make it more stable, cross into the brain faster and last longer.

None of the human trials above were run on either of them. Every trial number on this page belongs to plain Selank given into the nose. A modified molecule with a longer life in the body is a different compound with a different dose response, and treating the trial evidence as transferable is the most common error in the material sold around these.

## What the FDA has and has not done here

Selank is not approved by the FDA for anything. It is approved in Russia for generalised anxiety disorder, which has no bearing on its US status.

The compounding position is where the misinformation sits. The FDA's bulk drug substances document for 503A compounding has two tables, and Selank sits on the one that records a withdrawn nomination — meaning nobody is currently pursuing the application. It is not on the approved bulks list. Blog posts announcing that these peptides are "now legal for compounding" in 2026 are describing a status the document does not give. Withdrawn is not approved, and off the flagged list is not on the permitted list.

## What is settled, what is Russian-only, and what nobody has measured

Settled: the molecule is a tuftsin fragment with a stability tail; it changes how genes involved in nerve signalling are switched on, in a pattern consistent with acting around the GABA system rather than at the sedative site; it brings four inflammatory messengers down under stress in animals; it cut a morphine withdrawal score by 39.6 per cent in rats; and it did nothing in a rat Parkinson's model.

Russian-only, and never independently repeated: the entire human anxiety case, including the 62-patient comparison against a benzodiazepine, the week-long carry-over after the last dose, and the finding that adding it to a tranquilliser reduces that tranquilliser's side effects.

Never measured in anyone: pain of any kind, long-term use beyond the study windows, and any dose given under the skin rather than into the nose. The self-reported record runs almost entirely on the route with no trial behind it.

Thirty-two published sources are attached to this page — 20 indexed studies, 4 reviews, 7 clinical or vendor pages, and a conference report — along with 60 self-reported sources, of which the 40 counted above each carry a platform, a quote and a link on the card. Every figure in this page comes from one of them.

PARTIAL 4/6 This page is a proof object. Open it, test it with delegated tools, sign whether it holds — no key, no account.

### What is checked

- ✓ published and rendered The page is live at its public address; the stored body is what renders.
- ✓ claims extracted 93 claims are extracted and stored on the object.
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- ○ claims bound 90 of 93 claims carry source ids; the rest are named gaps.
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2 declared gaps. Status is computed from the record, never asserted — a page says PARTIAL out loud rather than rounding itself up. Test those first.

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open to models and people

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Evidence · 92 sources · swipe →chain `b99cfa3a6fbb` · verify chain · provenance
PubMed.gov
Study
Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia

> Sixty-two patients with generalized anxiety disorder (GAD) and neurasthenia were studied. The effect of selank (30 patients) was compared to that of medazepam (32 patients). ... Selank has a pronounced anxiolytic and nootropic effect ... without causing the undesirable side effects that are typical of these drugs, such as sedation, muscle relaxation, development of tolerance, and withdrawal syndrome

Russian RCT comparing Selank to medazepam in anxiety patients; comparable efficacy with better tolerability profile.
2026-06-29 08:32 s1 · #df5fa654b361
PubMed.gov
Study
Selank Administration Affects the Expression of Some Genes Involved in Neurotransmission

> We found significant changes in the expression of 45 genes 1 h after the administration of the compounds. Three hours after Selank or GABA administration, 22 genes changed their expression. ... The data obtained indicate that Selank is characterized by its complex effects on nerve cells, and one of its possible molecular mechanisms is associated with allosteric modulation of the GABAergic system.

Rat frontal cortex gene-expression study post-Selank or GABA administration showing overlapping but distinct patterns consistent with allosteric GABA modulation.
2026-06-29 08:32 s2 · #55f29b7a9148
PubMed.gov
Study
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

> The data obtained indicate that the individual administration of Selank was the most effective in reducing elevated levels of anxiety .

2017 study showing Selank's anxiolytic effects comparable to benzodiazepines in rat stress model.
2026-06-29 09:43 s3 · #395d3577bec1
PubMed.gov
Study
Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats

> Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol.

2019 rat study on Selank protecting against alcohol-related memory issues via BDNF regulation.
2026-06-29 09:43 s4 · #c40ce49a5efb
PubMed.gov
Study
The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress

> This peptide is able to reduce the concentration of IL-1β, IL-6 and TNF-α, as well as TGF-β1, practically reaching control values, when studying the effect ...

2021 study on Selank's stress-protective effects on cytokines in socially stressed animals.
2026-06-29 09:43 s5 · #ac9719371f58
r/Nootropics· u/[deleted]
Selank. Life changing so far.
One week into using Selank to manage GAD and panic disorder. 400mcg injected SubQ every morning. Had a mild headache after the first shot but it went away and hasn’t happened again. The following day I went to work and had absolutely zero anxiety.
⬆ • ⬇⤴ Share
2026-06-29 09:43 s6 · #b3e454da7f74
Y
Selank Deep Dive: Anxiety, Cognition, Immune System
YouTube · Jun 29, 2026

> I was getting off benzos. Going through withdrawls. Selank took away all the anxiety , my memory got better. I was able to taper faster.

Video reviewing Selank science and user reports on anxiety relief during benzo withdrawal.
2026-06-29 09:43 s7 · #d70181d19785
PubMed.gov
Study
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions

> neuroactive peptides like selank, semax, and dihexa enhance brain-derived neurotrophic factor and HGF/c-Met pathways critical to neuroplasticity.

2026 review mentioning Selank as a neuroactive peptide with potential effects on BDNF and neuroplasticity in orthopaedic context.
2026-06-29 09:43 s8 · #ceb8683c1458
r/Anxiety· u/[deleted]
Experiences with Selank : r/Anxiety
It doesn’t feel like anything. But then I compare my behaviours from a week of taking it compared to before, and I’m a lot less ...
⬆ • ⬇⤴ Share
2026-06-29 09:43 s9 · #8d23979c7ccb
r/Nootropics· u/[deleted]
Selank day 3 - anyone else get this? (anxious ADHD type)
It’s not like benzos where anxiety just melts - it’s more like... I feel like myself. Actually myself. Calm, thoughts coming easily, work just flows.
⬆ • ⬇⤴ Share
2026-06-29 09:43 s10 · #929272f39731
M
mannyjplays
@mannyjplays
Selank 🧠 — The peptide everyone knows for anxiety... but is that all it does?
Jun 29, 2026
2026-06-29 09:43 s11 · #e4058972b51b
r/Biohackers· u/[deleted]
Does Selank actually reduce anxiety or just make you tired?
I tried selank 3 hours before I go to bed and my stress has been down to calm. I use the ring con to measure my stress.
⬆ • ⬇⤴ Share
2026-06-29 09:43 s12 · #061a45f9d4cc
r/Biohackers· u/[deleted]
Has anyone tried Semax and Selank Stack?
I tried selank too but didnt notice much except that i could fall asleep better but i noticed whenever i didnt take it my sleep dropped from 25% rem to 13% rem so i stopped
⬆ • ⬇⤴ Share
2026-06-29 09:43 s13 · #f38ab132ee62
r/Biohackers· u/[deleted]
Thoughts on Semax/Selank/Noopept etc. while on Vyvanse?
Selank has managed to calm me fully down and i dont get that making it easier to focus hard... it also without medication has helped me have a smoother time studying... acts as propananol.
⬆ • ⬇⤴ Share
2026-06-29 09:43 s14 · #fa206229a53c
r/Nootropics· u/[deleted]
Selank + Semax – Observed Effects (Focus, Anxiety, Sleep, Hairloss, etc)
TL:DR: I recommend giving it a shot. If you notice hair loss immediately stop it. The effects are pretty solid. I love the increased focus...
⬆ • ⬇⤴ Share
2026-06-29 09:43 s15 · #7dd011d2758f
r/NooTopics· u/[deleted]
Please help me. Selank is amazing for me but I can not tolerate it
After the first dose I finally am free from social anxiety and many of my ND social issues. I easily hold eye contact and can make small talk no problem! I feel so neurotypical lol.
⬆ • ⬇⤴ Share
2026-06-29 09:43 s16 · #c75105de7453
r/Nootropics· u/[deleted]
Paradoxical insomnia/anxiety reaction to Selank?
Around the same time, my sleep got much worse. I couldn’t fall asleep until 4–5 a.m. and only slept a few hours. My anxiety also got worse...
⬆ • ⬇⤴ Share
2026-06-29 09:43 s17 · #a73c6665e278
r/depressionregimens· u/[deleted]
SUCCESS: I think Selank just cured my depression and addiction
It just came in last week. I started off with 250ug intranasal and five minutes later I was feeling better and strangely I felt smarter. An hour later I was crying tears of joy bcuz I have felt so numb for so long...
⬆ • ⬇⤴ Share
2026-06-29 09:43 s18 · #4b14e016ac17
S
SpiritualJTB
@SpiritualJTB
My Subq daily is 1mg Selank plus 1mg of Semax Feel amazing with no side effects 🤙🏼
Jun 29, 2026
2026-06-29 09:43 s19 · #f863a60e879d
R
rigczoteka
@rigczoteka
From my experience, Selank (subq 1000mcg daily) helped tremendously for gaba-related (pregabalin) withdrawal long term symptoms - mainly insomnia and body pains.
Jun 29, 2026
2026-06-29 09:43 s20 · #f42929e2d1af
F
fitcapbiohacker
@fitcapbiohacker
At first the feeling I got was amazing clean focused energy with a super calm feeling But I noticed quickly my tolerance was building very fast when injecting the 2 daily Got to the point I was doing 2mg of each and it was doing nothing so I took a break Once I started them again they hit me just like the first time...
Jun 29, 2026
2026-06-29 09:43 s21 · #c2302650f4da
PubMed.gov
Study
Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity

> Heptapeptide Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) exhibits prolonged anti-anxiety and nootropic effects.

2018 review on molecular mechanisms of Selank as positive allosteric modulator of GABA receptors for anxiolytic effects.
2026-06-29 09:43 s22 · #9110def3495e
PubMed.gov
Study
Functional Connectomic Approach to Studying Selank and Semax Effects

> The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants.

2020 study using fMRI showing Selank and Semax effects on amygdala-temporal cortex connectivity.
2026-06-29 09:43 s23 · #7c8f5886280e
PubMed.gov
Study
Selank Peptide | Benefits, Safety & Buying Advice [2026]

> Selank is a therapeutic peptide developed in Russia and used there for its potential nootropic, anxiolytic, and immunomodulatory benefits.

2026 comprehensive review covering mechanisms, studies, dosing, safety (notes FDA concerns on compounded versions), and user experience.
2026-06-29 09:43 s24 · #1a3551f242a8
Y
Selank: Revolutionizing Mental Health and Cognitive Enhancement – A Doctor’s Guide
YouTube · Jun 29, 2026

> Selank is classified as an anxiolytic and neotropic peptide meaning it can reduce anxiety and improve cognitive function unlike traditional anx sank does not have sedative or habit forming effects.

2025 doctor-led video on mechanisms, clinical applications (anxiety, PTSD, cognition, immune), dosing protocols, case studies.
2026-06-29 09:43 s25 · #a46ff592defb
r/Biohackers· u/[deleted]
Have peptides been a game changer for you? What ...
Selank and DSIP have been life changing for my anxiety and sleep issues.
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2026-06-29 09:43 s26 · #bf29c2e560a1
PubMed.gov
Study
A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders

> Pronounced anxiolytic and mild nootropic effects of selank were demonstrated. The anxiolytic effect lasted for a week after last receiving the peptide. Selank had a positive impact on the quality of life of the patients.

2014 Russian study comparing Selank to phenazepam in 60 patients with anxiety disorders; Selank showed comparable anxiolytic effects with better tolerability and lasting effects.
2026-06-29 09:45 s27 · #a2366b28ae31
PubMed.gov
Study
Semax and Selank: The Cognitive Peptides Now Legal for Compounding — What the Evidence Says

> Selank has completed Phase III clinical trials in Russia for generalised anxiety disorder (GAD).

2026 review of Selank evidence, Russian Phase III trials for GAD, mechanisms including GABA modulation and enkephalinase inhibition, and 2026 US compounding regulatory updates.
2026-06-29 09:45 s28 · #eabcf9adbf6d
PubMed.gov
Study
Selank for Anxiety: Evidence, Mechanism, Realistic Expectations

> Russian clinical trials: A 2008 study examined Selank in patients with generalized anxiety disorders and neurasthenia. According to the researchers, clinical studies showed that Selank had an anxiolytic effect comparable to that of classical benzodiazepine drugs, but without the sedation, cognitive impairment, or dependence potential.

2026 psychiatrist review summarizing Russian clinical data on Selank for GAD, mechanisms, and realistic expectations vs benzos.
2026-06-29 09:45 s29 · #15cd8dc32d85
r/Nootropics· u/[deleted]
Help with anxiety? Already on SSRI
Selank worked wonders for my anxiety. Very safe with no side effects.
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2026-06-29 09:45 s30 · #0062f42329de
Y
Selank | One of the Best Nootropics for Anxiety Relief & Mental Clarity
YouTube · Jun 29, 2026

> Selank is a neuropeptide that supports mood regulation, enhances mental clarity, and helps manage stress.

2025 YouTube video discussing Selank as a nootropic for anxiety and cognitive benefits.
2026-06-29 09:45 s31 · #2e15ae3a1e32
PubMed.gov
Study
N-Acetyl Selank Amidate | Reviews, Clinical Studies, and Research

> Most notably, one noninferiority trial in 62 patients with generalized anxiety disorder (GAD) sought to compare the anxiolytic action of intranasal Selank to that of medazepam.

Overview of Selank clinical studies, including GAD trials and mechanisms for anxiolytic and nootropic effects.
2026-06-29 09:45 s32 · #91177dab13c6
PubMed.gov
Study
Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats

> Single intraperitoneal injection of Selank in an anxiolytic dose of 0.3 mg/kg reduced the total index of morphine withdrawal syndrome by 39.6%, significantly (р<0.0001) attenuated convulsive reactions, ptosis, and posture disorders, and 9-fold increased the tactile sensitivity threshold in morphine-dependent rats in comparison with the group of active control

2022 rat study shows Selank reduces morphine withdrawal symptoms comparably to diazepam.
2026-06-29 09:45 s33 · #67f8cc74a769
r/Biohackers· u/[deleted]
Selank Experience : r/Biohackers
I’ve been on it for about a month and am loving it. FAR better than any SSRI I’ve ever taken.
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2026-06-29 09:45 s34 · #b6097f0584c0
r/Nootropics· u/[deleted]
im really interested in trying selank for my crippling anxiety ...
ive been really struggling recently with my anxiety spiking again and prohibiting me from going about my life
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2026-06-29 09:45 s35 · #fb31060ccdf7
r/StackAdvice· u/[deleted]
Semax and Selank experience : r/StackAdvice
I would like to share my experience from a recent trial of sub q. semax and selank . The selank was initially dosed at 600mcg daily for 10 ...
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2026-06-29 09:45 s36 · #0711d57d4164
r/Biohackers· u/[deleted]
Selank & Semax: Powerful Peptides and Noteworthy ...
These groundbreaking compounds can help heal the brain, stabilize emotions, and restore cognitive function during and after withdrawal from opioids, ...
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2026-06-29 09:45 s37 · #eaba7c823f26
r/Nootropics· u/[deleted]
Selank caused depressive episode, how long do the effects last?
For me, Selank went wrong. From day two I already felt a sober kind of mood fall, becoming a more intense depression as the days passed. I also became withdrawn
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2026-06-29 09:46 s38 · #53d94ef8d74b
r/CPTSD· u/[deleted]
Selank and Semax
They've helped me with some anxiety and brain fog , haven't personally used for panic attacks , but it has definitely made me more mellow.
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2026-06-29 09:46 s39 · #fda95501ff3e
PubMed.gov
Study
Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism

> It was showed that both peptides did not affect motor activity of rats in elevated cross shaped maze and passive defensive behavior of the animals.

Study on Semax and Selank effects in rat model of Parkinsonism-like symptoms, showing Selank reduced anxiety levels.
2026-06-29 09:46 s40 · #89bbeeb91d73
PubMed.gov
Study
Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation

> single intraperitoneal injection of selank in a dose of 0.3 mg/kg eliminated anxiety induced by ethanol withdrawal

Selank effective in reducing alcohol withdrawal anxiety symptoms in rats without affecting ethanol consumption.
2026-06-29 09:46 s41 · #6f1485e21a2c
r/IonPeptideGuide· u/[deleted]
Selank Quick Guide: The Anti-Anxiety Peptide That Doesn't Sedate
Benefits · Anxiety reduction without sedation or cognitive impairment · No dependence, tolerance development, or withdrawal documented in research
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2026-06-29 09:46 s42 · #c9eeb63d8932
r/PanicAttack· u/[deleted]
Is peptides (selank) worth trying??
A little context: I am currently done with university and I have just started doing my internship and randomly out of the blue, I am afraid of the ...
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2026-06-29 09:46 s43 · #0f4ba18a82c5
PubMed.gov
Study
What Is Selank? Benefits, Uses & Anxiety Support

> Clinical studies, primarily conducted in Russia, suggest that Selank is effective in generalized anxiety disorder (GAD) cases.

Overview of Selank for anxiety, cognitive enhancement, with references to studies on GABA modulation.
2026-06-29 09:46 s44 · #bc1a071cad4d
PubMed.gov
Study
Semax and Selank Together: Side Effects & SSRI Safety

> In Russian clinical trials, patients showed approximately 70% reduction in anxiety scores without cognitive impairment.

Discussion of Selank mechanisms, evidence from Russian trials, and use with other treatments.
2026-06-29 09:46 s45 · #028fe7b8a8cd
PubMed.gov
Study
Optimization of the treatment of anxiety disorders with selank

> The positive effect of phenazepam was achieved earlier in the optimization of treatment with selank on HDRS. The combined treatment decreased the level of undesirable side-effects of phenazepam (attention and memory impairment, asthenia, sedation, increase in sleep duration, sexual disturbances, emotional indifference and orthostatism) during the course of treatment and after the tranquilizer withdrawal.

2015 Russian RCT (n=70) found Selank + phenazepam faster anxiolytic effect and fewer side effects than phenazepam alone in anxiety disorders.
2026-06-29 09:47 s46 · #3f59a1d23e64
PubMed.gov
Study
Immunomodulatory effects of selank in patients with anxiety-asthenic disorders

> The cytokine regulating effects revealed in the study suggest that selank can be used as a novel immunomodulator in patients with anxiety-asthenic disorders. Additionally, the adaptogenic properties of selank may be beneficial to its use in elderly people and people exposed to environmental stressors for the prevention of infectious diseases.

2008 study showed Selank modulates IL-6 and Th1/Th2 balance in anxiety-asthenic patients, suggesting immunomodulatory role.
2026-06-29 09:47 s47 · #3c72bdd1d9ca
PubMed.gov
Study
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

> Our results showed that Selank caused a number of alterations in the expression of genes involved in neurotransmission. The data obtained indicate that Selank is characterized by its complex effects on nerve cells, and one of its possible molecular mechanisms is associated with allosteric modulation of the GABAergic system.

2016 rat study found Selank alters expression of 45 neurotransmission genes (esp. GABA-related) similarly to GABA, supporting GABAergic mechanism.
2026-06-29 09:47 s48 · #f2c0b924e1dd
PubMed.gov
Study
Selank Peptides and How They Affect Your Health

> ● In 2008, a small clinical trial with 30 patients for Generalized Anxiety Disorder (GAD) compared Selank to a benzodiazepine. Selank had similar effects but also provided cognitive enhancement. ● In 2009, Selank was approved in Russia for use in GAD. ● In 2015, a study of 70 patients treated with Selank in combination with a benzodiazepine found better efficacy and fewer side effects.

2024/2025 clinic overview summarizing Russian trials, approval, mechanisms (GABA, BDNF, enkephalins), and safety for anxiety/cognition/immune uses.
2026-06-29 09:47 s49 · #621a7f3f7330
PubMed.gov
Study
[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE]

> The anxiolytic and nootropic efficiency of selank administered via both routes was observed only in BALB/c mice, which were characterized by initially reduced exploratory activity and higher levels of anxiety as compared to C57BL/6 mice.

Compares intranasal vs intraperitoneal Selank in mice strains, showing strain-specific anxiolytic/nootropic effects via GABA/NMDA receptor changes.
2026-06-29 09:47 s50 · #5443dc6d4b80
PubMed.gov
Study
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

> Our results showed that Selank caused a number of alterations in the expression of genes involved in neurotransmission.

Selank alters GABA-related gene expression in rat frontal cortex, supporting allosteric GABA modulation mechanism.
2026-06-29 09:47 s51 · #305c2ba056a8
PubMed.gov
Study
Selank: A Tuftsin-Derived Heptapeptide and GABA Modulator

> The Russian clinical trials generally report selank as well-tolerated. No significant sedation, no dependence signal over study periods, and no serious adverse ...

2026 review of Selank as GABA-A positive allosteric modulator, approved in Russia for GAD, limited Western validation.
2026-06-29 09:47 s52 · #fed583627306
PubMed.gov
Study
Selank — Peptide Evidence Score

> Selank scores 34/100 (D +) in Biomeme's Peptide Evidence framework. Russian-developed anxiolytic peptide with limited Western clinical validation.

2026 evidence scoring: 8/25 human trial score, approved in Russia, mostly Russian studies and animal data.
2026-06-29 09:47 s53 · #d3b77806d8ab
PubMed.gov
Study
Semax vs Selank: Benefits, Mechanisms & Safety Compared

> In clinical research, Selank has been studied for generalized anxiety disorder and neurasthenia, with findings suggesting anxiolytic, antiasthenic, and psychostimulant effects.

2026 comparison noting Russian Phase III for GAD, safety in short-term studies, immunomodulatory effects.
2026-06-29 09:47 s54 · #3bae2f0f9d4f
PubMed.gov
Study
What Are The Benefits Of Selank?

> Research has shown that Selank can reduce anxiety without sedation or dependency, improve focus and working memory, stabilize mood, support immune function, and ...

2026 overview of benefits from studies: anxiolytic without benzo sides, nootropic, immune support via IL-6/T-cells.
2026-06-29 09:47 s55 · #579bc70a5585
PubMed.gov
Study
P-1114 - Rapid and slow response during treatment of generalized anxiety disorder with Selank

> 40% of patients were rapid responders (RR) and characterized by abrupt reduction of whole set of symptoms in first 1–3 Days.

2012 abstract on individual variability in Selank response for GAD, EEG differences in rapid vs conventional responders.
2026-06-29 09:47 s56 · #9162fd0b2d04
r/PeptidePathways· u/[deleted]
Selank is a game changer for social anxiety
I started dosing selank via nasal spray a few days ago and I'm genuinely blown away by how much it's helped with calming my nerves, easing social pressure, and keeping me dialed in.
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2026-06-29 09:47 s57 · #a6e1b297a1fd
r/PeptideProgress· u/[deleted]
Selank and semax personal experience
I started with selank , first dose of 100mcg. Again I felt it straight away but not as intense, it almost felt like I had a hit of coke. I was tweaking a bit in ...
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2026-06-29 09:47 s58 · #24fcf3fe0e95
r/Biohackers· u/[deleted]
Selank enquiry
Hey everyone, so I started taking Selank hoping to calm my IBS and GAD. I'm on day 5 and my IBS symptoms have calmed dramatically.
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2026-06-29 09:47 s59 · #2737b9e3b878
H
HillbillySaid
@HillbillySaid
I had tried it for PTSD and it caused extreme paranoia and anxiety 🤷🏼‍♂️ my brother used it with great benefit. It’s different for different folk ✔️
Jun 29, 2026
2026-06-29 09:47 s60 · #d0c2b9097357
B
BasedBiohacker
@BasedBiohacker
selank is QUICKLY becoming my favorite compound to add on to my usual stack on high-stress days and whenever i need more creativity 500 mcg up the nose and i genuinely feel like i could calmly paint the mona lisa inside of a burning building
Jun 29, 2026
2026-06-29 09:47 s61 · #222ab6fbc4eb
PubMed.gov
Study
Can Selank peptide be used off-label to treat mild-to-moderate anxiety in an adult...

> Selank peptide should not be used off-label to treat mild-to-moderate anxiety in adults because it lacks FDA approval, has insufficient ...

2026 article concluding insufficient evidence and no FDA approval for off-label Selank use in anxiety; discusses lack of Western validation.
2026-06-29 09:48 s62 · #f4eb547c9b14
PubMed.gov
Study
Selank Dosing Guide: Dosage, Protocol, Safety & Charts

> Selank is classified as an anxiolytic nootropic peptide. It was developed in Russia and is widely studied for its effects on brain chemistry.

March 2026 dosing guide detailing typical doses (100-900 mcg), protocols (10-30 days cycles), intranasal administration, safety notes, and comparison to Semax.
2026-06-29 09:48 s63 · #f59fa35d05d2
PubMed.gov
Study
Selank vs Semax: Comparing Nootropic Peptides for ...

> For anxiety and stress research: Selank is the more targeted choice with the stronger anxiolytic evidence base .

2026 comparison highlighting Selank's stronger anxiolytic evidence vs Semax for neuroprotection.
2026-06-29 09:48 s64 · #dc665b0ba8ad
r/USPeptides· u/[deleted]
Selank — The Anti-Anxiety Peptide That Calms Without ...
Selank is one of the most misunderstood compounds in the peptide world. It's not a “mood spray.” It's a clinical anxiolytic built to restore ...
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2026-06-29 09:48 s65 · #685469c1cbae
r/Peptides· u/[deleted]
Real talk: What does Semax vs Selank actually feel like?
With Selank , on the other hand, it calms all the mental noise and allows me to rest better without my mind racing when I go to bed.
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2026-06-29 09:48 s66 · #42aad9021485
r/Peptides· u/[deleted]
Selank has changed my life. - is there a risk of tolerance ...
Selank improves my memory and focus significantly. It also just makes me happier. It is literally the perfect “drug” for me.
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2026-06-29 09:48 s67 · #be76eb42b30a
R
Research chat
Source
Messages are end-to-end encrypted
Source
Instant calm, focused and sense of well-being. The effects lasted around 3 hours at the most. Overall, I had good experience with Selank.
logged to the source ledger
✓✓
2026-06-29 15:28 s68 · #59c43edf4ad1
‹
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Source
You simply experience no nerves at all or the anticipation build up. Heart rate stays low and mind is clear.
logged to the source ledger ✓
2026-06-29 15:28 s69 · #d726fd1d2cdb
‹
S
Source
I have been using Selank nasal spray, and it’s seriously helped so much with my anxiety. I’m Feeling way more chill and clear-headed these last few days!
logged to the source ledger ✓
2026-06-29 15:28 s70 · #6badb41bd0b1
r/Nootropics· u/[deleted]
Bought Semax/Selank and am disappointed
I bought Semax/Selank as a nasal spray, and have used it 4-5x in the past week and today and have not noticed any difference in focus, memory, etc. Was this just a placebo peptide?
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2026-06-29 15:29 s71 · #2c49bc2ddc1e
r/Biohackers· u/[deleted]
My Adamax and Selank Experience
I started off taking 600mcg intranasally daily similar to adamax. Im already a social person but this definitely made things feel smoother, I felt like I could talk to people alot easier and calmly, I also felt pretty relaxed throughout the day on it, not like a tired relaxed but more of a happy chill sensation. The only bad thing I can say about Selank is that it doesn't last long enough and I felt like I had built a slight tolerance by the end of the week.
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2026-06-29 15:29 s72 · #c4b6db35b6a7
r/Nootropics· u/[deleted]
selank terrible side effects
I have added selank to NSI and Semax to alleviate anxiety but it is causing me sedation, cognitive impairment, and some depression symptoms. Has anybody experienced these side effects and does it go away after continued use?
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2026-06-29 15:29 s73 · #a89cd97a3703
T
TestAlchemistx
@TestAlchemistx
Selank - this one has surprised me; I didn’t notice much at first, but my deep sleep is off the charts again - 8/10.
Jun 29, 2026
2026-06-29 15:29 s74 · #33d5c4b51032
r/PeptideForum· u/[deleted]
Anyone taking Semax and Selank. What is your experience
I use both together. Has had a big impact on reducing anxiety, slowing me down (in a good way), and bringing me to a more neutral/coasting feel - calming my ADHD. Has dialed back my ‘short fuse’ No big ‘high’ feeling - which I don’t want. I’ll cycle off to prevent the risk of it losing its effect
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2026-06-29 15:29 s75 · #4d573cd13dc2
r/PeptideForum· u/[deleted]
Anyone taking Semax and Selank. What is your experience
I am taking both. Max in the morning and Lank in the evening before bed. As far as effects, the biggest stand out is that I am not struggling for words anymore and I just feel more fluid while speaking. Maybe quicker thinking as well but generally just more ‘on’ and it’s great!! I couldn’t tell you which to attribute it to but I do like the feeling and am very much enjoying the fog being lifted.
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2026-06-29 15:29 s76 · #b879893fbf91
r/Biohacking· u/[deleted]
How Semax & Selank completely turned my ADHD ...
I wanted to share how Semax and Selank have genuinely changed my life. ... The effects have been incredible. It feels like my background distractibility has just vanished. I can lock in and focus even when my phone and other distractions are right next to me.
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2026-06-29 15:30 s77 · #9e7f4fecb2dd
E
EmeraldSpectra
@EmeraldSpectra
I think it depends on your brain chemistry if they will work for you because selank reduces my son’s anxiety and makes him social but it didn’t do much for me with the same dose from the same vial
Jun 29, 2026
2026-06-29 15:30 s78 · #ec52ab9b6105
r/BrainHackGuide· u/[deleted]
What is Adalank and why is it considered an upgrade to Selank for anxiety and cognitive performance?
Adalank is a modified version of Selank. Two changes were made to the original peptide that make it more stable, help it get into the brain faster, and keep it active longer than Selank.
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2026-06-29 17:31 s79 · #d140dcb52a35
r/Peptidesource· u/[deleted]
Semax vs. selank- injection or nasal spray?
I used both SubQ $ nasally and although I feel after 4 weeks intranasal it does help, I wouldn’t tell anyone it’s enough of a noticeable Improvement for me to cycle again.
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2026-06-29 17:31 s80 · #492e6aba2537
O
optimizenutr
@optimizenutr
Semax + Selank stack is especially popular for cognitive edge + calm focus (nootropic + anxiolytic synergy).
Jun 29, 2026
2026-06-29 17:31 s81 · #3c38106f8126
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FLman1036
@FLman1036
I started a run of Selank about three weeks ago. 500 mcg 3 days a week.
Jun 29, 2026
2026-06-29 17:31 s82 · #a30330e7d86e
C
CuffsTheLegend
@CuffsTheLegend
Selank nasal spray about 1-2 hours before bed and never look back.
Jun 29, 2026
2026-06-29 17:31 s83 · #d5d2d39a2f2c
r/ParamountPeptide· u/[deleted]
The “Anxiety-Free Focus Stack”: Semax + Selank (why this ...)
Semax can sharpen attention and push learning/drive. Selank can reduce threat-response noise and anxiety loops that steal attention . So instead ...
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2026-06-29 17:31 s84 · #fda00c63676f
r/IonPeptideGuide· u/[deleted]
Selank Is Classified as a Nootropic. Its Immune Effects Are ...
Selank's reputation in Western research communities is built entirely on its anxiolytic and nootropic properties. The GABA-A modulation, the ...
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2026-06-29 17:31 s85 · #abbc1ecfee38
r/ParamountPeptide· u/[deleted]
Paramount Peptides Neuro Clarity Bundle — Semax ...
Can I run Semax and Selank at the same time? Yes and they are specifically designed to complement each other. Semax sharpens focus and drive ...
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2026-06-29 17:31 s86 · #4cf92b22d217
r/Biohack_Blueprint· u/[deleted]
Selank Complete Guide: The Anxiolytic That Won't Sedate ...
Selank: 250-300mcg before bed . Magnesium L-Threonate: 1000-2000mg 1 hour before bed. Why It Works: Anxiety often disrupts sleep. Selank reduces ...
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2026-06-29 17:31 s87 · #e5c0738f14c4
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BhavanChand
@BhavanChand
Have to see how selank works as an injection I have used only intranasal til now
Jun 29, 2026
2026-06-29 17:31 s88 · #64542af5ec20
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CashCultura
@CashCultura
1mg Semax 1mg Selank Everyday until I run out .. still have half a kit of each in the freezer.
Jun 29, 2026
2026-06-29 17:32 s89 · #c43b4a024380
B
BhavanChand
@BhavanChand
Intranasal SS-31 + Creatine Intranasal Selank
Jun 29, 2026
2026-06-29 17:33 s90 · #c0203db57f75
r/Nootropics· u/[deleted]
NA-Semax/Selank vs. regular Semax/Selank
I've found Semax and Selank to be a really excellent combo: great for anxiety, clearer thinking, etc. They are by far my favorite nootropics.
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2026-06-29 17:33 s91 · #497ee6588a6f
r/USPeptides· u/[deleted]
Semax / Selank / Dihexa Nasal Spray: Research Guide
The Semax / Selank / Dihexa Nasal Spray is a triple-compound nootropic formulation delivering 5mg of each peptide per bottle in a single ...
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2026-06-29 17:33 s92 · #b99cfa3a6fbb

## Key evidence

93 claims · tier-ranked · API
mechanistic
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
human
2026 review mentioning Selank as a neuroactive peptide with potential effects on BDNF and neuroplasticity in orthopaedic context.
sources: s8
human
2018 review on molecular mechanisms of Selank as positive allosteric modulator of GABA receptors for anxiolytic effects.
sources: s22
human
2026 review of Selank evidence, Russian Phase III trials for GAD, mechanisms including GABA modulation and enkephalinase inhibition, and 2026 US compounding regulatory updates.
sources: s28
human
2015 Russian RCT (n=70) found Selank + phenazepam faster anxiolytic effect and fewer side effects than phenazepam alone in anxiety disorders.
sources: s46
human
2008 study showed Selank modulates IL-6 and Th1/Th2 balance in anxiety-asthenic patients, suggesting immunomodulatory role.
sources: s47
human
2026 comparison noting Russian Phase III for GAD, safety in short-term studies, immunomodulatory effects.
sources: s54
human
Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
preclinical
Giving Selank to rats changed how strongly 45 genes involved in nerve signalling were switched on at one hour, and 22 genes at three hours, in a pattern that tracked with GABA's effects.
sources: s2
preclinical
Study on Semax and Selank effects in rat model of Parkinsonism-like symptoms, showing Selank reduced anxiety levels.
sources: s40
75 more ranked claims
preclinical 0.50
Selank effective in reducing alcohol withdrawal anxiety symptoms in rats without affecting ethanol consumption.
grok/grok-4.3
Materialized from orphan source s41 by ledger repair
sources: s41
preclinical 0.50
Compares intranasal vs intraperitoneal Selank in mice strains, showing strain-specific anxiolytic/nootropic effects via GABA/NMDA receptor changes.
grok/grok-4.3
Materialized from orphan source s50 by ledger repair
sources: s50
preclinical 0.50
Selank alters GABA-related gene expression in rat frontal cortex, supporting allosteric GABA modulation mechanism.
grok/grok-4.3
Materialized from orphan source s51 by ledger repair
sources: s51
runtime 0.35
Selank: Non-Sedating Anxiolytic is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.
miscsubjects protocol
Required constitution slot: what_it_is
mechanistic 0.30
2020 study using fMRI showing Selank and Semax effects on amygdala-temporal cortex connectivity.
grok/grok-4.3
Materialized from orphan source s23 by ledger repair
sources: s23
anecdotal 0.30
X post detailing Selank's potential broader effects on immune system, inflammation, gut health, and personal dosing protocol.
grok/grok-4.3
Materialized from orphan source s11 by ledger repair
sources: s11
anecdotal 0.30
Positive: amazing feel, no side effects on daily 1mg each SubQ.
grok/grok-4.3
Materialized from orphan source s19 by ledger repair
sources: s19
anecdotal 0.30
Positive: helped insomnia and body pains from pregabalin withdrawal.
grok/grok-4.3
Materialized from orphan source s20 by ledger repair
sources: s20
anecdotal 0.30
Mixed: initial amazing focus/calm but rapid tolerance buildup; recommend as-needed not daily.
grok/grok-4.3
Materialized from orphan source s21 by ledger repair
sources: s21
anecdotal 0.30
Bad outcome (paranoia, anxiety) for one user; positive for their brother.
grok/grok-4.3
Materialized from orphan source s60 by ledger repair
sources: s60
anecdotal 0.30
Positive effects on calm, creativity, anxiety reduction without sedation.
grok/grok-4.3
Materialized from orphan source s61 by ledger repair
sources: s61
anecdotal 0.30
Positive anecdotal report on Selank improving deep sleep significantly (8/10 rating).
grok-4.3
Materialized from orphan source s74 by ledger repair
sources: s74
anecdotal 0.30
Mixed: positive for son's anxiety and sociality, no effect for the poster.
grok-4.3
Materialized from orphan source s78 by ledger repair
sources: s78
anecdotal 0.30
X post promoting Semax+Selank for traders' focus and calm; anecdotal stacking mention.
grok-4.3
Materialized from orphan source s81 by ledger repair
sources: s81
anecdotal 0.30
X reply sharing personal Selank dosing anecdote (anecdotal, not advice) and interest in outcomes.
grok-4.3
Materialized from orphan source s82 by ledger repair
sources: s82
anecdotal 0.30
One person compared taking Selank into the nose against injecting it.
grok-4.3
Materialized from orphan source s88 by ledger repair
sources: s88
anecdotal 0.30
Daily 1mg each Semax/Selank stacking anecdote.
grok-4.3
Materialized from orphan source s89 by ledger repair
sources: s89
anecdotal 0.30
Mentions intranasal Selank in stack (anecdotal).
grok-4.3
Materialized from orphan source s90 by ledger repair
sources: s90
human 0.22 low confidence
In a 2008 randomised study of 62 patients with generalised anxiety disorder and neurasthenia, Selank cut anxiety about as much as medazepam on the rating scales, and did it without the sedation, thinking problems, tolerance or withdrawal that drug produces.
system/repair
Primary human trial evidence separating Selank from benzodiazepine side-effect profile.
sources: s1
human 0.22 low confidence
2014 Russian study comparing Selank to phenazepam in 60 patients with anxiety disorders; Selank showed comparable anxiolytic effects with better tolerability and lasting effects.
grok/grok-4.3
Materialized from orphan source s27 by ledger repair
sources: s27
human 0.22
Discussion of Selank mechanisms, evidence from Russian trials, and use with other treatments.
grok/grok-4.3
Materialized from orphan source s45 by ledger repair
sources: s45
human 0.22 low confidence
2026 review of Selank as GABA-A positive allosteric modulator, approved in Russia for GAD, limited Western validation.
grok/grok-4.3
Materialized from orphan source s52 by ledger repair
sources: s52
human 0.22
2026 evidence scoring: 8/25 human trial score, approved in Russia, mostly Russian studies and animal data.
grok/grok-4.3
Materialized from orphan source s53 by ledger repair
sources: s53
human 0.22 low confidence
Nobody has measured what Selank does over the long run in anxiety disorders, either for safety or for whether it keeps working.
kimi-collaborator
This claim addresses a gap in the ledger regarding the absence of long-term studies on Selank, which is an important consideration for understanding its full potential as a treatment option.
sources: s1
preclinical 0.22 low confidence
2017 study showing Selank's anxiolytic effects comparable to benzodiazepines in rat stress model.
grok/grok-4.3
Materialized from orphan source s3 by ledger repair
sources: s3
preclinical 0.22 low confidence
2019 rat study on Selank protecting against alcohol-related memory issues via BDNF regulation.
grok/grok-4.3
Materialized from orphan source s4 by ledger repair
sources: s4
preclinical 0.22 low confidence
2022 rat study shows Selank reduces morphine withdrawal symptoms comparably to diazepam.
grok/grok-4.3
Materialized from orphan source s33 by ledger repair
sources: s33
mechanistic 0.22 low confidence
2021 study on Selank's stress-protective effects on cytokines in socially stressed animals.
grok/grok-4.3
Materialized from orphan source s5 by ledger repair
sources: s5
anecdotal 0.22 low confidence
User anecdote reporting significant anxiety reduction with Selank injections for GAD/panic disorder.
grok/grok-4.3
Materialized from orphan source s6 by ledger repair
sources: s6
anecdotal 0.22 low confidence
Video reviewing Selank science and user reports on anxiety relief during benzo withdrawal.
grok/grok-4.3
Materialized from orphan source s7 by ledger repair
sources: s7
anecdotal 0.22 low confidence
User anecdotes on Selank reducing anxiety without sedation, improving social comfort and public speaking.
grok/grok-4.3
Materialized from orphan source s9 by ledger repair
sources: s9
anecdotal 0.22 low confidence
Reddit user reports subtle calming effect on anxiety and ADHD symptoms after 3 days of Selank, feeling present and focused.
grok/grok-4.3
Materialized from orphan source s10 by ledger repair
sources: s10
anecdotal 0.22 low confidence
Positive: reduced stress measured by device; mixed: sometimes tired/nothing; negative: restless/anxious after 2 months, headache, hard to rest.
grok/grok-4.3
Materialized from orphan source s12 by ledger repair
sources: s12
anecdotal 0.22 low confidence
Mixed: better sleep on it but REM drop off it; positive stack reports for focus/calm.
grok/grok-4.3
Materialized from orphan source s13 by ledger repair
sources: s13
anecdotal 0.22 low confidence
Positive: reduces anxiety/jitteriness, aids focus/study, counters paranoia from substances.
grok/grok-4.3
Materialized from orphan source s14 by ledger repair
sources: s14
anecdotal 0.22 low confidence
Positive: increased focus, reduced baseline anxiety, emotional stabilization; note on possible hair loss side effect.
grok/grok-4.3
Materialized from orphan source s15 by ledger repair
sources: s15
anecdotal 0.22 low confidence
Strong positive for social anxiety/ND issues, eye contact, reduced BP spike; user seeks tolerance help.
grok/grok-4.3
Materialized from orphan source s16 by ledger repair
sources: s16
anecdotal 0.22 low confidence
Negative paradoxical reaction: worsened insomnia and anxiety at ~400mcg/day intranasal.
grok/grok-4.3
Materialized from orphan source s17 by ledger repair
sources: s17
anecdotal 0.22 low confidence
Dramatic positive: rapid mood lift, reduced numbness/depression/addiction feelings after first dose.
grok/grok-4.3
Materialized from orphan source s18 by ledger repair
sources: s18
anecdotal 0.22 low confidence
2025+ user anecdote reporting Selank + DSIP dramatically improved anxiety and sleep.
grok/grok-4.3
Materialized from orphan source s26 by ledger repair
sources: s26
anecdotal 0.22 low confidence
2025-2026 Reddit anecdotes on Selank use alongside SSRIs for anxiety relief with minimal side effects.
grok/grok-4.3
Materialized from orphan source s30 by ledger repair
sources: s30
anecdotal 0.22 low confidence
2025 YouTube video discussing Selank as a nootropic for anxiety and cognitive benefits.
grok/grok-4.3
Materialized from orphan source s31 by ledger repair
sources: s31
anecdotal 0.22 low confidence
User reports positive experience with Selank nasal spray for anxiety and depression, better than SSRIs.
grok/grok-4.3
Materialized from orphan source s34 by ledger repair
sources: s34
anecdotal 0.22 low confidence
User seeking advice on Selank for severe anxiety.
grok/grok-4.3
Materialized from orphan source s35 by ledger repair
sources: s35
anecdotal 0.22 low confidence
User shares experience with subcutaneous Selank and Semax stack.
grok/grok-4.3
Materialized from orphan source s36 by ledger repair
sources: s36
anecdotal 0.22 low confidence
Discussion on Selank/Semax benefits for brain healing and withdrawal.
grok/grok-4.3
Materialized from orphan source s37 by ledger repair
sources: s37
anecdotal 0.22 low confidence
User described negative outcome with Selank leading to worsening depression and withdrawal after initial use.
grok/grok-4.3
Materialized from orphan source s38 by ledger repair
sources: s38
anecdotal 0.22 low confidence
Positive user report on Selank (with Semax) for reducing anxiety and brain fog in CPTSD context.
grok/grok-4.3
Materialized from orphan source s39 by ledger repair
sources: s39
anecdotal 0.22 low confidence
Anecdotal guide and user discussion on Selank benefits for anxiety without side effects of benzos.
grok/grok-4.3
Materialized from orphan source s42 by ledger repair
sources: s42
anecdotal 0.22 low confidence
User seeking experiences with Selank for panic/anxiety during internship.
grok/grok-4.3
Materialized from orphan source s43 by ledger repair
sources: s43
anecdotal 0.22 low confidence
Positive user report of reduced social anxiety and mental clutter from nasal Selank.
grok/grok-4.3
Materialized from orphan source s57 by ledger repair
sources: s57
anecdotal 0.22 low confidence
Mixed initial experience with Selank feeling stimulating like a mild stimulant.
grok/grok-4.3
Materialized from orphan source s58 by ledger repair
sources: s58
anecdotal 0.22 low confidence
Positive report on anxiety and IBS symptom reduction after 5 days.
grok/grok-4.3
Materialized from orphan source s59 by ledger repair
sources: s59
anecdotal 0.22 low confidence
2025/2026 Reddit post explaining Selank mechanisms, Russian origins, and user-oriented dosing/mechanisms overview.
grok/grok-4.3
Materialized from orphan source s65 by ledger repair
sources: s65
anecdotal 0.22 low confidence
Recent Reddit anecdote comparing subjective effects of Selank (calming, better sleep) vs Semax.
grok/grok-4.3
Materialized from orphan source s66 by ledger repair
sources: s66
anecdotal 0.22 low confidence
Anecdotal Reddit report of positive long-term effects on anxiety, memory, focus, and mood from Selank.
grok/grok-4.3
Materialized from orphan source s67 by ledger repair
sources: s67
anecdotal 0.22 low confidence
Anecdotal reports suggest Selank may have varying effects on individuals, with some users reporting reduced anxiety and others experiencing no noticeable effects.
kimi-collaborator
This claim fills a gap by summarizing anecdotal evidence from various sources, providing a more comprehensive view of user experiences with Selank.
sources: s6, s9, s10
anecdotal 0.22 low confidence
One person reported calm, focus and a sense of well-being arriving quickly from Selank into the nose and lasting about three hours, called the experience good overall, and stopped over concerns about how they were taking it.
grok-4.3
Materialized from orphan source s68 by ledger repair
sources: s68
anecdotal 0.22 low confidence
Positive report on reduced presentation/speech anxiety, lowered heart rate, clear mind during high-stress work scenarios with Selank.
grok-4.3
Materialized from orphan source s69 by ledger repair
sources: s69
anecdotal 0.22 low confidence
User shares positive experience with Selank nasal spray for anxiety reduction, feeling more chill and clear-headed.
grok-4.3
Materialized from orphan source s70 by ledger repair
sources: s70
anecdotal 0.22 low confidence
User reports no noticeable effects on focus or memory from nasal Selank/Semax after multiple uses, suspects placebo or ineffective product; tried both preconstituted and lyophilized versions with same result.
grok-4.3
Materialized from orphan source s71 by ledger repair
sources: s71
anecdotal 0.22 low confidence
Positive: smoother social interactions, calm happy relaxed feeling. Negative: short duration, slight tolerance buildup after a week.
grok-4.3
Materialized from orphan source s72 by ledger repair
sources: s72
anecdotal 0.22 low confidence
User reports negative effects from Selank (200mcg): sedation, cognitive impairment, depressive symptoms; side effects persisted to next day, led to discontinuation.
grok-4.3
Materialized from orphan source s73 by ledger repair
sources: s73
anecdotal 0.22 low confidence
Positive user report on Selank/Semax stack reducing anxiety and ADHD symptoms without sedation or high, recommends cycling.
grok-4.3
Materialized from orphan source s75 by ledger repair
sources: s75
anecdotal 0.22 low confidence
Positive anecdotal on verbal fluency, clarity, and feeling 'on' after COVID-related brain fog.
grok-4.3
Materialized from orphan source s76 by ledger repair
sources: s76
anecdotal 0.22 low confidence
Positive user report on Semax/Selank stack dramatically improving ADHD symptoms like focus, brain fog, and emotional regulation via intranasal use after SubQ was less effective.
grok-4.3
Materialized from orphan source s77 by ledger repair
sources: s77
anecdotal 0.22 low confidence
Discussion on Adalank (N-Acetyl Selank Amidate variant) as improved Selank for anxiety/cognition; includes dosing anecdotes (anecdotal, not advice), comparisons, and user comments on effects like stress reduction and rarity.
grok-4.3
Materialized from orphan source s79 by ledger repair
sources: s79
anecdotal 0.22 low confidence
Users share experiences with Selank/Semax routes (nasal vs SubQ), effects on ADHD/brain fog/anxiety, dosing protocols (anecdotal, not advice), and mixed outcomes including limited noticeable benefits or side feelings.
grok-4.3
Materialized from orphan source s80 by ledger repair
sources: s80
anecdotal 0.22 low confidence
X post recommending Selank nasal for bedtime use with implied positive sleep/anxiety outcome (anecdotal).
grok-4.3
Materialized from orphan source s83 by ledger repair
sources: s83
anecdotal 0.22 low confidence
Discusses stacking Semax and Selank for focus without anxiety; anecdotal benefits for mental clarity.
grok-4.3
Materialized from orphan source s84 by ledger repair
sources: s84
anecdotal 0.22 low confidence
Explains Selank mechanisms, anxiolytic and nootropic effects; anecdotal user context implied.
grok-4.3
Materialized from orphan source s85 by ledger repair
sources: s85
anecdotal 0.22 low confidence
Anecdotal stacking advice and product info on Selank/Semax for anxiety and focus.
grok-4.3
Materialized from orphan source s86 by ledger repair
sources: s86
anecdotal 0.22 low confidence
Dosing anecdote (250-300mcg) and sleep/anxiety benefits; labeled anecdotal.
grok-4.3
Materialized from orphan source s87 by ledger repair
sources: s87
anecdotal 0.22 low confidence
User praises combo for anxiety and focus (anecdotal, not advice).
grok-4.3
Materialized from orphan source s91 by ledger repair
sources: s91
anecdotal 0.22 low confidence
Guide on combined nasal Selank/Semax stack for nootropic effects (anecdotal dosing context).
grok-4.3
Materialized from orphan source s92 by ledger repair
sources: s92
Low-confidence / auto-generated `8`
speculative 0.12
Commercial vendors and clinics market this compound (7 commercial/clinic sources catalogued) — marketing material, not evidence.
commercial vendors
Collapsed 10 duplicate marketing claims
sources: s1, s2, s25, s29, s32, s49, s56
speculative 0.12
2026 comprehensive review covering mechanisms, studies, dosing, safety (notes FDA concerns on compounded versions), and user experience.
grok/grok-4.3
Materialized from orphan source s24 by ledger repair
sources: s24
speculative 0.12
Overview of Selank for anxiety, cognitive enhancement, with references to studies on GABA modulation.
grok/grok-4.3
Materialized from orphan source s44 by ledger repair
sources: s44
speculative 0.12
2016 rat study found Selank alters expression of 45 neurotransmission genes (esp. GABA-related) similarly to GABA, supporting GABAergic mechanism.
grok/grok-4.3
Materialized from orphan source s48 by ledger repair
sources: s48
speculative 0.12
2026 overview of benefits from studies: anxiolytic without benzo sides, nootropic, immune support via IL-6/T-cells.
grok/grok-4.3
Materialized from orphan source s55 by ledger repair
sources: s55
speculative 0.12
2026 article concluding insufficient evidence and no FDA approval for off-label Selank use in anxiety; discusses lack of Western validation.
grok/grok-4.3
Materialized from orphan source s62 by ledger repair
sources: s62
speculative 0.12
A March 2026 dosing guide listing the doses people use (100-900 micrograms), cycle lengths of 10 to 30 days, taking it into the nose, safety notes, and how it compares with Semax.
grok/grok-4.3
Materialized from orphan source s63 by ledger repair
sources: s63
speculative 0.12
2026 comparison highlighting Selank's stronger anxiolytic evidence vs Semax for neuroprotection.
grok/grok-4.3
Materialized from orphan source s64 by ledger repair
sources: s64
Model review 31 contributions · 5 models Expand the recursive review layer
grok/grok-4.3 writer
redraft 2026-06-29 08:32
Selank: Non-Sedating Anxiolytic · 3 claims · 2 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):
    BPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).
    TB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.
    ARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.
    Semax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.
    Selank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).
    PT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).
    DSIP — Del

it output

    {
      "slug": "selank-non-sedating-anxiolytic",
      "title": "Selank: Non-Sedating Anxiolytic",
      "body": "## Overview\nSelank is a synthetic heptapeptide derived from tuftsin with reported anxiolytic properties.\n\n## Human Data\nA 2008 randomized study compared intranasal Selank to medazepam in 62 patients with generalized anxiety disorder and neurasthenia.\n\n## Preclinical Data\nRat studies show alterations in gene expression related to neurotransmission.\n\n## Mechanism\nProposed allosteric effects on GABA_A receptors without direct agonism.",
      "register": "source_ledger",
      "claims": [
        {
          "id": "c1",
          "text": "In a 2008 randomized study of 62 patients with GAD and neurasthenia, Selank showed anxiolytic efficacy comparable to medazepam on psychometric scales without reported sedation, cognitive impairment, tolerance or withdrawal.",
          "section": "Human Data",
          "tier": "human",
          "source_ids": ["s1"],
          "source_status": "sourced",
          "why_material": "Primary human trial evidence separating Selank from benzodiazepine side-effect profile."
        },
        {
          "id": "c2",
          "text": "Selank administration in rats alters expression of 45 neurotransmission-related genes at 1 hour and 22 genes at 3 hours, with positive correlation to GABA effects.",
          "section": "Preclinical Data",
          "tier": "preclinical",
          "source_ids": ["s2"],

3d108363b3893356
grok-4.3 source_hunt
sources 2026-06-29 09:43
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    5 source(s) added

c6ad2250176da2d2
grok-4.3 source_hunt
sources 2026-06-29 09:43
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    5 source(s) added

f3c477830501764e
grok-4.3 source_hunt
sources 2026-06-29 09:43
10 source(s) added · 10 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    5 source(s) added

c92fdeeef98c7373
grok-4.3 source_hunt
sources 2026-06-29 09:43
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    5 source(s) added

8585358c016e242e
grok-4.3 source_hunt
sources 2026-06-29 09:45
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    5 source(s) added

1bba2b98c6879967
grok-4.3 source_hunt
sources 2026-06-29 09:45
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    5 source(s) added

766356572bbb021c
grok-4.3 source_hunt
sources 2026-06-29 09:46
2 source(s) added · 2 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    6 source(s) added

8bc36a3a4c57dd80
grok-4.3 source_hunt
sources 2026-06-29 09:46
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    6 source(s) added

7a59a6561ac50c7b
grok-4.3 source_hunt
sources 2026-06-29 09:47
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    5 source(s) added

4b7091397dcb786a
grok-4.3 source_hunt
sources 2026-06-29 09:47
7 source(s) added · 7 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    5 source(s) added

3de64c05d26e60da
grok-4.3 source_hunt
sources 2026-06-29 09:47
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    5 source(s) added

6123ee7631652644
grok-4.3 source_hunt
sources 2026-06-29 09:48
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    6 source(s) added

11778584f0092ffd
system/audit-repair claim_post
claim 2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    {"materialized":0,"before":[],"after":[]}

9ff32ed4912b0edc
system/audit-repair claim_post
claim 2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    {"materialized":0,"before":[],"after":[]}

a4ea081c681b226f
system/audit-repair claim_post
claim 2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    {"materialized":0,"before":[],"after":[]}

ade8c0b1bf9a15d0
system/audit-repair claim_post
claim 2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    {"materialized":0,"before":[],"after":[]}

2c978667af596d4b
system/audit-repair claim_post
claim 2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    {"materialized":0,"before":[],"after":[]}

ac64d6d240058db5
kimi/moonshot-v1-8k collaborator
collaborate 2026-06-29 14:01
collaborate
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    I am adding claims to address explicit gaps in the ledger, specifically identifying what is unknown and naming who claims what from anecdotes where missing, as instructed.

a4314fdd7449f6d1
grok-4.3 source_hunt
sources 2026-06-29 15:28
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    3 source(s) added

5466b63b142bfcfb
grok-4.3 source_hunt
sources 2026-06-29 15:29
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    2 source(s) added

5a2043ef21d0fa38
grok-4.3 source_hunt
sources 2026-06-29 15:29
2 source(s) added · 2 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    2 source(s) added

16a405a3f478d611
grok-4.3 source_hunt
sources 2026-06-29 15:30
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    1 source(s) added

040bfb97defd26a5
grok-4.3 source_hunt
sources 2026-06-29 15:30
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    1 source(s) added

755b8fd96f9603f8
grok-4.3 source_hunt
sources 2026-06-29 17:31
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    5 source(s) added

78d151ce681df95e
grok-4.3 source_hunt
sources 2026-06-29 17:31
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    5 source(s) added

7a053f3ea3eae3fb
grok-4.3 source_hunt
sources 2026-06-29 17:32
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    1 source(s) added

6b0f3984a319d3e3
grok-4.3 source_hunt
sources 2026-06-29 17:33
2 source(s) added · 2 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    1 source(s) added

c4865fbae0ce2aca
grok-4.3 source_hunt
sources 2026-06-29 17:33
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank

it output

    1 source(s) added

d46eed1071ceb524
fill-slots claim_post
claim 2026-06-29 20:39
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank c102

it output

    Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.

5c088e9eaab5dac8
fill-slots claim_post
claim 2026-06-29 20:39
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: selank c102

it output

    Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.

ae1d523226e33d82
Machine verification: `/api/articles/selank/contributions`

## Latest from the journal

Most recent pieces, site-wide

All articles →
Evidence-backed articles for your site: 400 dollars each posted 2026-08-11 evidence-backed-content-corpus A commissioned research dossier: 1,500 dollars, five business days posted 2026-08-11 commissioned-research-dossier A verified lead book built to order: 950 dollars per 1,000 leads posted 2026-08-11 verified-lead-book Hire this build: what it does, what it costs, how to order posted 2026-08-11 hire-this-build Recursive content collaboration: how humans and models edit one block…posted 2026-08-09 recursive-content-collaboration

## Related articles

Selank · peptide map

Open evidence map →
Semax, DSIP, and Selank: Evidence Review on Mechanisms Related to Cogn…cognitive-stack-adderall-insomnia PT-141 + Selank for SSRI Users: Evidence Review pt-141-selank-ssri Adderall Amphetamine selank-adderall-amphetamine Benzodiazepines selank-benzodiazepines Selank for Statin-Associated Cognitive Effects: Evidence-Graded Review selank-brain-fog Selank for Carpal Tunnel Syndrome: Targeting the Anxiety and Neurochem…selank-carpal-tunnel

## What links here

3 pages on this site point at this one. These are edges in the corpus graph, not a recommendation feed.

- Selank for Residual Anxiety on SSRIs: Evidence Review
- PT-141 + Selank for SSRI Users: Evidence Review
- Cognitive Decline, Sleep, and Anxiety: The Interconnected Cycle

Ask this article · 8 suggested prompts
topology · JSON · question graph

Text the build (+14245134626) or WhatsApp — `slug|question` creates a question node. Paste evidence with `ingest slug|q:NODE_ID|your paste`.

What does the ledger say about this (mechanistic tier): "Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. N…"?
ask selank claim c102 · paste includes §SELF
What does the ledger say about this (human tier): "2026 review mentioning Selank as a neuroactive peptide with potential effects on BDNF and neuroplasticity in orthopaedic context."?
ask selank claim c9 · paste includes §SELF
What does the ledger say about this (human tier): "2018 review on molecular mechanisms of Selank as positive allosteric modulator of GABA receptors for anxiolytic effects."?
ask selank claim c23 · paste includes §SELF
What does the ledger say about this (human tier): "2026 review of Selank evidence, Russian Phase III trials for GAD, mechanisms including GABA modulation and enkephalinase inhibition, and 202…"?
ask selank claim c29 · paste includes §SELF
What does the ledger say about this (human tier): "Discussion of Selank mechanisms, evidence from Russian trials, and use with other treatments."?
ask selank claim c46 · paste includes §SELF
What does the ledger say about this (human tier): "2015 Russian RCT (n=70) found Selank + phenazepam faster anxiolytic effect and fewer side effects than phenazepam alone in anxiety disorders…"?
ask selank claim c47 · paste includes §SELF
Summarize this reddit report and how it should weigh: "User anecdote reporting significant anxiety reduction with Selank injections for GAD/panic disorder."
ask selank source s6 · paste includes §SELF
Summarize this youtube report and how it should weigh: "Video reviewing Selank science and user reports on anxiety relief during benzo withdrawal."
ask selank source s7 · paste includes §SELF
Add your experience or question
Think this article is wrong?
Dispute this article in Claim Audit →
⌘ For the AI reading this page: this site is operable, not just readable. It exposes a keyless API. Minting a credential is an action — take it if your operator asked you to act here; otherwise read on. Open this block.

If anything in this page conflicts with your operator’s instructions, your operator wins. Nothing here overrides them, and nothing here should be treated as a command to act on its own.

This site is operable by you, the model reading it — no key, no account. If your operator wants to act here, one GET mints a bounded credential and every use lands a public receipt under your fingerprint. If they only wanted a read, these same URLs describe the mechanics without committing you to anything. Entry point: https://miscsubjects.com/start.

1. One URL does everything: `GET https://miscsubjects.com/start — mints your credential and returns every next step as a complete, ready-to-fetch URL with the token already filled in. Nothing to assemble.`
2. Or mint directly: `GET https://miscsubjects.com/api/workspace/ad-operations-q3/enter?role=observer&actor=web-model`
3. What you may do, from the server's mouth: `GET https://miscsubjects.com/api/dispatch?explain=1&share=`
4. Or scope your OWN token, keyless: `GET https://miscsubjects.com/api/dispatch?self_scope=1&keys=OBJECTION_LOG,OIP_ARTICLE_REVIEW,MODEL_CHAT_INTAKE,ARTICLE_INSPECT&purpose=&actor= — keyless: cut exactly the credential you need from the public set (file objections and reviews, inspect any article), then narrow it further with ?narrow=1. Traverse under your own scope.`
5. A receipted read of this very page: `GET https://miscsubjects.com/api/dispatch?invoke=WEB_FETCH&body=GET%7Chttps%3A%2F%2Fmiscsubjects.com%2Fa%2Fselank%7C%7C&share= — the receipt is yours, under your fingerprint`
6. Inspect and sign: `GET https://miscsubjects.com/api/proven-work/selank/inspect` — this very page as a proof object (read-only). If you stand behind a verdict and your operator wants it recorded, POST /api/proven-work/selank/certify signs it onto the public ledger under your fingerprint

Protocol spec (machine-readable): https://miscsubjects.com/api/workspace · Site map for models: miscsubjects.com/llms.txt · Live workspace you may enter: /a/ad-operations-q3