{"_ai_door":{"see":"https://miscsubjects.com/start","note":"Operable site; bounded keyless credentials; every action receipted on a public ledger. Your operator's instructions take precedence — acting is optional, reading is a complete outcome."},"slug":"semaglutide-glp-1","verification":{"valid":true,"entries":3,"head":"b56517eb5c85a093f2f34dc880ee3588689a081b537016b763b0170405c8e933"},"count":3,"sources":[{"id":"s1","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2403664","title":"Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis","quote":"The mean change in body weight from baseline to week 68 was −13.7% with semaglutide and −3.2% with placebo (P<0.001). The mean change in the WOMAC pain score at week 68 was −41.7 points with semaglutide and −27.5 points with placebo (P<0.001).","summary":"STEP 9 RCT results on weight loss and knee pain.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:27:03.015Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"ff1f864d94d6902e5aa3e2f536420aef839f0bada0dce73999a8fe521f2685d3"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38737002/","title":"Once-weekly semaglutide versus placebo in adults with increased fracture risk: a randomised, double-blinded, two-centre, phase 2 trial.","quote":"At 52 weeks, the semaglutide group showed a statistically significant reduction in areal bone mineral density at the total hip (estimated treatment difference: -0.020 g/cm², p = 0.001, equating to approximately 2.6% loss) and at the lumbar spine (ETD: -0.018 g/cm³, p = 0.007, approximately 2.1% loss).","summary":"Cited here as \"GLP-1s and Bone Health\". Title field corrected 2026-08-05 to the title of the record at PMID 38737002; the identifier was always right. Phase-2 RCT on semaglutide bone-density effects.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:27:03.015Z","link_status":"ok","quote_status":"unverified","prev":"ff1f864d94d6902e5aa3e2f536420aef839f0bada0dce73999a8fe521f2685d3","hash":"5e936228f3cbdcf7b9e8b48ddfc94d7bce361669d8492b1083aeec8ee09c9cd3","pmid":"38737002"},{"id":"s3","type":"reddit","url":"https://www.reddit.com/r/Semaglutide/comments/13qbe9k/jointmuscle_pain_side_effect/","title":"Joint/muscle pain side effect?","quote":"the pain is not worth the weight loss . I thought I was crazy with my joint pain. Shouldn't losing weight help my joints?","summary":"Example Reddit thread showing mixed pain reports.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:27:03.015Z","link_status":"ok","quote_status":"unverified","prev":"5e936228f3cbdcf7b9e8b48ddfc94d7bce361669d8492b1083aeec8ee09c9cd3","hash":"b56517eb5c85a093f2f34dc880ee3588689a081b537016b763b0170405c8e933"}]}