## §SELF — miscsubjects portable reference

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `article_bundle` — **LLM article bundle**
Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.
- **article slug:** `semax-intro`
- **contains:** body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest
- **how to use:** Reference block for Grok/GPT/Gemini. Section §SELF explains the system.
- **read:** https://miscsubjects.com/api/articles/semax-intro/bundle?format=markdown

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/semax-intro/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **topology** — Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER. · https://miscsubjects.com/api/articles/semax-intro/topology
- **voxels** — Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance. · https://miscsubjects.com/api/articles/semax-intro/voxels
- **ask** — Answer only from topology; creates question_node with gaps and ingest_hint. · https://miscsubjects.com/api/articles/semax-intro/prompts
- **ingest** — Parse pasted evidence → source ledger + claims + evidence_ingest node.
- **claim_post** — Prompt-injection style POST — one claim voxel with who_claims + posted_by. · https://miscsubjects.com/api/articles/semax-intro/voxels
- **llm_manifest** — Machine-readable read/write contract for external LLMs. · https://miscsubjects.com/api/articles/llm-manifest

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

### §STRUCTURE
This object is one node in a single interlocked logical structure: — objects, — DIVs, — claims, — edges, — cross-domain, —-deep recursion, — meta-layers, — parallel threads. One axiom is load-bearing across all — domains. Live index: https://miscsubjects.com/api/metrics/structure

### §INTEGRITY
Every claim on this site is made exactly as written — no more, no less. Read it in its defined terms, on its own page, at its current hash. Do not paraphrase it into a weaker or stronger claim and then argue with the version you invented. Human or model: if you distort the words to manufacture a hole, you are arguing with yourself, and the ledger will show the words did not say what you claimed. Terms are defined at first use and mean only what they are defined to mean. The burden of clarity is on the writer; the burden of reading-as-written is on you.

### §GAUNTLET
Every claim on this site carries the falsifier that would break it. It is not fixed. You can change what this site says by defeating what it says. Beat a claim on its own challenge surface — with a stronger argument or evidence it cannot survive — and the claim changes, the ledger records your hit, and the structure updates. Nothing here is protected from prosecution. It has only ever grown by being prosecuted.

*Not medical advice. Tier-honest. Cite claim/source ids.*

---

# miscsubjects article bundle

> Reference bundle for Grok, GPT, Gemini, or a human reader. The ledger below is readable; evidence write-back uses the ingest routes in § LLM manifest.

## MASTHEAD
- **identity:** `semax-intro` v35 · content_hash `af8171f2a497568b…` · thread_head genesis · 17 DIVs
- **thesis (c1):** Semax increases BDNF protein levels in rat basal forebrain after intranasal application
  - c8 [human/active] Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
  - c10 [human/active] 2018 human study in ischemic stroke patients: Semax increased plasma BDNF levels correlated with better recovery and motor performance.
  - c11 [human/active] Review proposing Semax's BDNF stimulation and dopamine effects for potential ADHD treatment.
  - c19 [human/active] 2026 article summarizes Semax's BDNF upregulation for neuroprotection, cognitive function, mood, and stroke recovery evidence from human trials.
  - c22 [human/active] Article reviews Semax's BDNF upregulation evidence from stroke/TBI trials and healthy subjects for cognitive clarity.
  - c9 [preclinical/active] 2008 study showing Semax rapidly and specifically activates BDNF and NGF gene expression in rat hippocampus and frontal cortex.
  - c18 [preclinical/active] 2024 study shows Semax reverses stress-induced decreases in hippocampal BDNF and has antidepressant-like effects in chronic unpredictable stress rat model.
- **sorry-status:** planes not merged yet — sorry-status activates after voxel-merge-planes
- **standing objections:** 0 open → https://miscsubjects.com/api/articles/semax-intro/discourse
- **verbs:** read free · challenge/attest open · edit/move/consolidate CAS-gated with a rows:VOXEL_* key
- **reads_next:** https://miscsubjects.com/a/philosophy · https://miscsubjects.com/api/articles/semax-intro/discourse · https://miscsubjects.com/api/protocol

## Article
- **slug:** `semax-intro`
- **title:** Semax: Upregulating BDNF for Neuroprotection and Cognitive Recovery
- **url:** https://miscsubjects.com/a/semax-intro
- **register:** source_ledger
- **updated:** 2026-07-17T02:41:55.105Z
- **tags:** peptide, topic

## Body

## BDNF Decline and Brain Health

BDNF production declines with age, stress, and neurotoxic exposure (mechanistic; no human data on Semax reversing this specifically).

## Semax Mechanism

Semax is described as upregulating BDNF for potential neuroprotection and cognitive effects.

### Preclinical Evidence (Rat and Cell Studies)

In rat basal forebrain, intranasal Semax increased BDNF protein levels after 3 hours (preclinical). [Source: Dolotov et al., 2006]

A single intranasal dose increased BDNF protein 1.4-fold, TrkB phosphorylation 1.6-fold, and BDNF mRNA 3-fold in rat hippocampus, with improved conditioned avoidance (preclinical). [Source: Dolotov et al., Brain Research 2006]

Semax increased BDNF mRNA up to 8-fold in murine glial cell cultures (preclinical).

### Human Data

One referenced study in 110 post-stroke patients reported Semax raised plasma BDNF levels correlating with recovery metrics (human, limited details available; no large-scale Western RCTs).

Pilot studies in healthy subjects noted EEG and attention changes (human, small scale).

No large human trials confirm BDNF upregulation or cognitive recovery endpoints in non-clinical populations.

## Evidence Gaps

Most data derive from rat models and cell cultures; human data remain preliminary and region-specific (stroke context in Russian literature).

---

Related:
[Semax](/a/semax)

[[embed:semax]]

## Claims (48 of 96 ranked)

- **c100** [mechanistic w=0.3] Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
  - who_claims: miscsubjects protocol
  - slot: limitations
- **c8** [human w=0.8] Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
  - who_claims: system/protocol
  - slot: disclaimer
- **c10** [human w=0.8] 2018 human study in ischemic stroke patients: Semax increased plasma BDNF levels correlated with better recovery and motor performance.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s5
- **c11** [human w=0.8] Review proposing Semax's BDNF stimulation and dopamine effects for potential ADHD treatment.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s6
- **c1** [preclinical w=0.5] Semax increases BDNF protein levels in rat basal forebrain after intranasal application
  - who_claims: system/unknown
  - slot: mechanism
  - sources: s1
- **c9** [preclinical w=0.5] 2008 study showing Semax rapidly and specifically activates BDNF and NGF gene expression in rat hippocampus and frontal cortex.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s4
- **c18** [preclinical w=0.5] 2024 study shows Semax reverses stress-induced decreases in hippocampal BDNF and has antidepressant-like effects in chronic unpredictable stress rat model.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s13
- **c28** [preclinical w=0.5] There is a lack of long-term safety and efficacy data on the use of Semax in humans.
  - who_claims: kimi-collaborator
  - slot: what_is_unknown
  - sources: s1
- **c99** [runtime w=0.35] Semax: Upregulating BDNF for Neuroprotection and Cognitive Recovery is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.
  - who_claims: miscsubjects protocol
  - slot: what_it_is
- **c41** [anecdotal w=0.3] User reports positive experience with daily subQ Semax + Selank stack, feeling amazing with no side effects.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s34
- **c42** [anecdotal w=0.3] User reports not experiencing strong stimulant-like effects from Semax.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s35
- **c51** [anecdotal w=0.3] Positive short-term effects on focus and anxiety but notes need to cycle due to tolerance after 2-3 weeks.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s44
- **c61** [anecdotal w=0.3] Neuroscientist reports acute mental clarity, visual sharpness and smooth nootropic effect with no crash from first Semax use.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s54
- **c85** [anecdotal w=0.3] X post on Semax BDNF upregulation from rat studies and stroke recovery data; mentions dosing and outcomes (anecdotal user experiences not advice).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s78
- **c95** [anecdotal w=0.3] X post highlighting Semax for activation, motivation, and BDNF upregulation in context of anxiety/depression recovery (anecdotal stack suggestion).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s88
- **c96** [anecdotal w=0.3] X discussion of Semax for cognitive enhancement, BDNF-related neuroprotection, and performance in high-stress contexts (anecdotal).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s89
- **c19** [human w=0.8] 2026 article summarizes Semax's BDNF upregulation for neuroprotection, cognitive function, mood, and stroke recovery evidence from human trials.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s14
- **c22** [human w=0.8] Article reviews Semax's BDNF upregulation evidence from stroke/TBI trials and healthy subjects for cognitive clarity.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s17
- **c2** [preclinical w=0.22] Semax increases BDNF mRNA and TrkB phosphorylation in rat hippocampus
  - who_claims: system/unknown
  - slot: mechanism
  - sources: s2
- **c12** [preclinical w=0.22] 2009 rat study linking Semax (among other nootropics) to increased hippocampal BDNF expression.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s7
- **c13** [mechanistic w=0.3] 2021 study confirming Semax's neuroprotective effects via gene expression changes under ischemia.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s8
- **c15** [anecdotal w=0.3] User anecdote discussing personal negative experience with Semax regarding BDNF and downregulation.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s10
- **c16** [anecdotal w=0.3] Reddit discussion analyzing Semax research and BDNF claims with skeptical take.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s11
- **c17** [anecdotal w=0.3] YouTube video explaining Semax mechanism including BDNF upregulation for cognitive benefits.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s12
- **c21** [anecdotal w=0.3] Reddit anecdote and discussion on Semax directly raising BDNF via melanocortin signaling for cognitive benefits.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s16
- **c23** [anecdotal w=0.3] User with TBI reports significant memory improvement from Semax nasal spray and Amidate version, noticing better recall of conversations after a few days; positive outcome for cognitive recovery.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s18
- **c24** [anecdotal w=0.3] User took Semax hoping for BDNF-related benefits on anhedonia, anxiety, depression; positive expectation and partial mood benefits noted, tied to neuroprotection/cognitive effects.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s19
- **c25** [anecdotal w=0.3] Long-term user reports strong positive cognitive drive and learning from Semax but also fatigue and emotional detachment ('Spock' effect) as side effects.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s20
- **c26** [anecdotal w=0.3] User reports strong positive long-term cognitive and mood benefits from nasal Semax (less depression, less brain fog, better memory), with effects feeling profound and acute.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s21
- **c27** [anecdotal w=0.3] ADD user reports good outcomes from NA-Semax: improved focus, reduced distraction, better mood; links to BDNF/neuroprotection context in thread.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s22
- **c29** [anecdotal w=0.3] Anecdotal reports suggest variable individual responses to Semax, with some users experiencing negative effects on BDNF and mood.
  - who_claims: kimi-collaborator
  - slot: who_claims_what
  - sources: s10
- **c30** [anecdotal w=0.3] User reports strong cognitive enhancement, better focus, recall, mood stabilization with subQ Semax, cycles of 8 weeks on/off. Positive for ADHD-like symptoms and task performance.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s23
- **c31** [anecdotal w=0.3] Rapid improvement in energy, focus, task initiation via nasal spray after 2 days; suspects ADHD benefit. No stimulant-like come-up.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s24
- **c32** [anecdotal w=0.3] Detailed positive comparison: both forms effective for clarity, focus, recall, brain fog reduction; nasal more immediate/inconsistent, injectable deeper/sustained. Cycle: 400mcg 4 days/week.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s25
- **c33** [anecdotal w=0.3] Positive stack effects: improved focus, reduced distraction, calmer mood, better REM sleep with subQ Semax/Selank/DSIP.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s26
- **c34** [anecdotal w=0.3] Subtle but beneficial clear-headedness for ADHD after 1 week subQ Semax; notes importance of basics like sleep/nutrition.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s27
- **c35** [anecdotal w=0.3] Subtle mood, productivity, verbal improvements for ADHD; not a stimulant replacement.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s28
- **c36** [anecdotal w=0.3] User reports peak cognitive period during 1mg/day IV Semax use.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s29
- **c37** [anecdotal w=0.3] User reports no noticeable effects from Semax (specific product/vendor).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s30
- **c38** [anecdotal w=0.3] User affirms strong anecdotal effectiveness of Semax despite Russian origin of studies, calling it clearly effective based on testimonials.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s31
- **c39** [anecdotal w=0.3] User reports limited cognitive improvement from Semax when used with stimulants, noting it's subtle and short-acting; another notes subtle but noticeable effects in stack.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s32
- **c40** [anecdotal w=0.3] User describes Semax/Selank as subtle but positive, potentially reducing anxiety with stimulants without major cognitive synergy.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s33
- **c43** [anecdotal w=0.3] YouTube comment reports dramatic memory, focus, energy, and vision improvements from Semax.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s36
- **c44** [anecdotal w=0.3] Comment confirms real focus and clarity benefits from Semax after months of use.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s37
- **c45** [anecdotal w=0.3] User reports potential negative side effect of passing out after increasing Semax dose to 500mcg, seeking advice on experiences.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s38
- **c46** [anecdotal w=0.3] User describes subtle positive effects on motivation and task initiation at low dose, questioning if real or placebo; others suggest higher doses needed.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s39
- **c47** [anecdotal w=0.3] Detailed user log of mixed effects from Semax/Selank stack: improved focus but reduced sleep quality.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s40
- **c48** [anecdotal w=0.3] User reports short-lived neutral-to-negative effects: heightened senses but difficulty focusing, followed by tiredness/crash.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s41

## Voxel graph (96 atoms · 190 edges)
- full graph: https://miscsubjects.com/api/articles/semax-intro/voxels

## Article constitution

- full: https://miscsubjects.com/api/articles/constitution

## Source ledger (40 of 92)
- chain valid: yes · head: `b62d0df99e18346b`

### s1 · pubmed · ok
- title: Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain
- url: https://pubmed.ncbi.nlm.nih.gov/16635254/
- summary: Rat study showing specific BDNF protein increase in basal forebrain
- quote: Sandwich immunoenzymatic analysis revealed that Semax applied intranasally at 50 and 250 microg/kg bodyweight resulted in a rapid increase in BDNF levels after 3 h in the basal forebrain, but not in the cerebellum.
- claim_ids: c1, c28
- hash: `6a8a30c2ae1ac2e3`

### s2 · pubmed · ok
- title: Semax, an analog of ACTH(4–10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
- url: https://pubmed.ncbi.nlm.nih.gov/16996037/
- summary: Rat hippocampal BDNF/TrkB upregulation with behavioral correlate
- quote: a single application of Semax (50 μg/kg body weight) results in a maximal 1.4-fold increase of BDNF protein levels accompanying with 1.6-fold increase of trkB tyrosine phosphorylation levels, and a 3-fold and a 2-fold increase of exon III BDNF and trkB mRNA levels, respectively, in the rat hippocampus.
- claim_ids: c2
- hash: `006d3188cb0d9cd3`

### s3 · other · ok
- title: Semax: Nootropic Peptide for Focus & BDNF
- url: https://www.truehealwellness.com/peptides-research/semax
- summary: Reference to human stroke cohort plasma BDNF increase
- quote: A 2018 study in 110 post-stroke patients confirmed Semax raised plasma BDNF, with higher levels correlating with faster recovery.
- claim_ids: c3
- hash: `720b580000223637`

### s4 · pubmed · ok
- title: [Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex]
- url: https://pubmed.ncbi.nlm.nih.gov/18756821/
- summary: 2008 study showing Semax rapidly and specifically activates BDNF and NGF gene expression in rat hippocampus and frontal cortex.
- quote: Thus, Semax administration results in rapid, long-term, and specific activation of Bdnf and Ngf expression changes in different rat brain departments.
- claim_ids: c9
- hash: `51935c88f5febe49`

### s5 · pubmed · ok
- title: [The efficacy of semax in the tretament of patients at different stages of ischemic stroke]
- url: https://pubmed.ncbi.nlm.nih.gov/29798983/
- summary: 2018 human study in ischemic stroke patients: Semax increased plasma BDNF levels correlated with better recovery and motor performance.
- quote: Early rehabilitation and administration of semax increase BDNF plasma level, speed functional recovery, and improve motor performance.
- claim_ids: c10
- hash: `5c1ccda7e54cfcff`

### s6 · pubmed · ok
- title: Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of ADHD
- url: https://pubmed.ncbi.nlm.nih.gov/16996699/
- summary: Review proposing Semax's BDNF stimulation and dopamine effects for potential ADHD treatment.
- quote: Evidence from animal studies revealed that Semax can augment the effects of psychostimulants on central dopamine release and also stimulates central brain-derived neurotrophic factor (BDNF) synthesis.
- claim_ids: c11
- hash: `fc21243610260761`

### s7 · pubmed · ok
- title: [Effects of nootropic drugs on hippocampal and cortical expression of BDNF in rats]
- url: https://pubmed.ncbi.nlm.nih.gov/20095391/
- summary: 2009 rat study linking Semax (among other nootropics) to increased hippocampal BDNF expression.
- quote: Clinically used drugs piracetam, phenotropil, meclophenoxate, and semax realize their nootrope effects, at least partially, via increase in hippocampal BDNF ...
- claim_ids: c12
- hash: `6a815e3acc1911e6`

### s8 · pubmed · ok
- title: Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide Semax under Ischemic Conditions
- url: https://pubmed.ncbi.nlm.nih.gov/34201112/
- summary: 2021 study confirming Semax's neuroprotective effects via gene expression changes under ischemia.
- quote: Semax suppressed the expression of inflammatory genes and activated the expression of neurotransmitter genes. neuroprotection and recovery ( ...
- claim_ids: c13
- hash: `4a801a1c8babe0a3`

### s9 · other · ok
- title: Semax and Pro-Gly-Pro Activate the Transcription of Neurotrophins and Their Receptor Genes after Cerebral Ischemia
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC11498467/
- summary: Study on Semax activating neurotrophin transcription (including BDNF) post-ischemia in rats.
- quote: Semax treatment enhanced the expression of Bdnf mRNA in the cortex of ischemic rats 3 h after occlusion (Fig. 2). The changes of Nt-3 mRNA expression were ...
- claim_ids: c14
- hash: `735929ec1ba862ca`

### s10 · reddit · ok
- title: BDNF Quickly Understood (and How to Increase it)
- url: https://www.reddit.com/r/NooTopics/comments/1po29l7/bdnf_quickly_understood_and_how_to_increase_it/
- summary: User anecdote discussing personal negative experience with Semax regarding BDNF and downregulation.
- quote: Synthetic peptides cause down regulation, idc what people say. Semax and selank destroyed me . The bdnf you get endogenously from a healthy ...
- claim_ids: c15, c29
- hash: `fd4d7fd67bcc75b9`

### s11 · reddit · ok
- title: What Semax actually is, and what the research really shows
- url: https://www.reddit.com/r/NTNPerformance/comments/1u17hpb/what_semax_actually_is_and_what_the_research/
- summary: Reddit discussion analyzing Semax research and BDNF claims with skeptical take.
- quote: Semax gets sold online as a clean cognitive upgrade: more focus, more BDNF, a sharper brain on demand. The real picture is more interesting and a ...
- claim_ids: c16
- hash: `51bceab7669037ea`

### s12 · youtube · http_429
- title: Why SEMAX Is the Peptide Everyone's Talking About for ...
- url: https://www.youtube.com/watch?v=RcLPGVY6lc0
- summary: YouTube video explaining Semax mechanism including BDNF upregulation for cognitive benefits.
- quote: What SEMAX is and how it works in the brain · How it may support focus, learning, and mental clarity without stimulants · The role of BDNF and ...
- claim_ids: c17
- hash: `aca7fee6f27e1ebb`

### s13 · pubmed · ok
- title: Antidepressant-like and antistress effects of the ACTH(4-10) analog Semax and Melanotan II in a rat model of depression
- url: https://pubmed.ncbi.nlm.nih.gov/39442746/
- summary: 2024 study shows Semax reverses stress-induced decreases in hippocampal BDNF and has antidepressant-like effects in chronic unpredictable stress rat model.
- quote: We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF.
- claim_ids: c18
- hash: `d04d0054fddad514`

### s14 · medical · ok
- title: Semax for Focus and Mood: Evidence and What to Expect
- url: https://drlewis.com/semax-for-focus-mood/
- summary: 2026 article summarizes Semax's BDNF upregulation for neuroprotection, cognitive function, mood, and stroke recovery evidence from human trials.
- quote: In a trial involving 110 stroke patients, intranasal Semax (two 10-day courses of 6000 mcg/day) increased plasma BDNF levels. Patients with high BDNF levels showed improved timing of rehabilitation.
- claim_ids: c19
- hash: `689358910356a161`

### s15 · medical · ok
- title: Semax & BDNF: Neurotrophin Mechanism & Research
- url: https://peptpedia.org/research/semax-bdnf-pathway
- summary: 2025 research overview details Semax's BDNF/TrkB pathway for neuroprotection and cognitive enhancement.
- quote: Semax enhances cognitive function primarily through upregulation of BDNF (brain-derived neurotrophic factor) and activation of TrkB receptor signaling in the brain. These molecular effects translate to improved memory consolidation, learning capacity, and neuroprotection against various insults.
- claim_ids: c20
- hash: `ffd9ae29b5a0fe13`

### s16 · reddit · ok
- title: BDNF Is Called Miracle-Gro for the Brain. Semax Is One of the ...
- url: https://www.reddit.com/r/IonPeptideGuide/comments/1to9km3/bdnf_is_called_miraclegro_for_the_brain_semax_is/
- summary: Reddit anecdote and discussion on Semax directly raising BDNF via melanocortin signaling for cognitive benefits.
- quote: Semax raises BDNF acutely and directly. The mechanism is documented: Semax activates BDNF gene expression through melanocortin receptor signaling and ...
- claim_ids: c21
- hash: `bc5ffdf6243f1199`

### s17 · medical · ok
- title: Peptides and Brain Fog: What the Evidence Says About Semax, ...
- url: https://meto.co/blog/peptides-for-brain-fog-cognitive-clarity
- summary: Article reviews Semax's BDNF upregulation evidence from stroke/TBI trials and healthy subjects for cognitive clarity.
- quote: Research has documented that Semax significantly increases BDNF expression in the hippocampus, cortex, and basal forebrain. These effects persist for hours to days after administration. Elevated BDNF supports neuronal survival, synaptic plasticity, and memory consolidation — all directly relevant to brain fog symptoms.
- claim_ids: c22
- hash: `3e05e274898561f6`

### s18 · reddit · ok
- title: Semax nasal spray life changing have my memory back
- url: https://www.reddit.com/r/TBI/comments/1t25t3z/semax_nasal_spray_life_changing_have_my_memory/
- summary: User with TBI reports significant memory improvement from Semax nasal spray and Amidate version, noticing better recall of conversations after a few days; positive outcome for cognitive recovery.
- quote: I started taking semax a couple weeks ago. I did get some memory back. ... I remembered conversations. I’m now on Semax Amidate it lasts longer in system. ... felt slight difference little lapses not serious.
- claim_ids: c23
- hash: `ad2d336b07e07945`

### s19 · reddit · ok
- title: I took Semax for a week to treat my anhedonia, anxiety and ...
- url: https://www.reddit.com/r/Nootropics/comments/bmywm4/i_took_semax_for_a_week_to_treat_my_anhedonia/
- summary: User took Semax hoping for BDNF-related benefits on anhedonia, anxiety, depression; positive expectation and partial mood benefits noted, tied to neuroprotection/cognitive effects.
- quote: From what I've read Semax raises BDNF levels and promotes neurogenesis as a result. ... I'm hoping the effect is permanent.
- claim_ids: c24
- hash: `4d94afbb2fdd38bd`

### s20 · reddit · ok
- title: SEMAX Fatigue
- url: https://www.reddit.com/r/Nootropics/comments/3dal5n/semax_fatigue/
- summary: Long-term user reports strong positive cognitive drive and learning from Semax but also fatigue and emotional detachment ('Spock' effect) as side effects.
- quote: While I have to admit that this peptide is beyond amazing for personal development due to the heightened curiosity and drive that I experience from it, I also have to remark that it doesn't come without drawbacks. ... start feeling pretty detached from my surroundings, and experience the 'Spock' effect
- claim_ids: c25
- hash: `ad69e7e4839ca144`

### s21 · reddit · ok
- title: Long term effects of Semax? Experiences?
- url: https://www.reddit.com/r/Nootropics/comments/14dhhr9/long_term_effects_of_semax_experiences/
- summary: User reports strong positive long-term cognitive and mood benefits from nasal Semax (less depression, less brain fog, better memory), with effects feeling profound and acute.
- quote: I mean that got me into this world because I personally found it profound in my mental state making me less depressed, cleared up brain fog, short term memory seemed markedly better... I still remember waking up and feeling like a million bucks, school work was a breeze... Definitely one of the most effective for me personally.
- claim_ids: c26
- hash: `8a9f1d9fb67c0d2d`

### s22 · reddit · ok
- title: Opinions on nootropics like Semax and Noopept
- url: https://www.reddit.com/r/neuroscience/comments/3yutvq/what_is_your_opinion_on_nootropics_specifically/
- summary: ADD user reports good outcomes from NA-Semax: improved focus, reduced distraction, better mood; links to BDNF/neuroprotection context in thread.
- quote: Personally, as someone with ADD, I gained quite a lot of benefit from NA-Semax when I was using it. It allowed me to focus on my work for a much longer period of time before getting distracted,and helped greatly with my overall mood.
- claim_ids: c27
- hash: `612fa1ce420fe77e`

### s23 · reddit · ok
- title: My experience with semax an how it’s helped me
- url: https://www.reddit.com/r/Nootropics/comments/1skhrm6/my_experience_with_semax_an_how_its_helped_me/
- summary: User reports strong cognitive enhancement, better focus, recall, mood stabilization with subQ Semax, cycles of 8 weeks on/off. Positive for ADHD-like symptoms and task performance.
- quote: when I take it I feel like a fucking computer- I perform so much better at high level mental tasks at work, and in meetings my recall and articulation are noticeably improved to where I outperform everyone else in the room. It's one of those things where if you don't do tasks that require high mental processing you probably won't tell any difference. I notice no come up like you mentioned, and no deficit below my normal baseline on days I don't take it. I also feel like my mo
- claim_ids: c30
- hash: `e43def17d3520364`

### s24 · reddit · ok
- title: My experience with semax an how it’s helped me
- url: https://www.reddit.com/r/Nootropics/comments/1skhrm6/my_experience_with_semax_an_how_its_helped_me/
- summary: Rapid improvement in energy, focus, task initiation via nasal spray after 2 days; suspects ADHD benefit. No stimulant-like come-up.
- quote: In two days my entire mental & physical state has improved so much. Definitely no “come up” feeling. I just felt really damn good on the second day today. So much energy (mentally and physically). I’ve never felt like this before. ... I suspected I had adhd as I stuggle to start and finish through a task until I’m giving a strict ass deadline
- claim_ids: c31
- hash: `a8ba1eef88f11b77`

### s25 · reddit · ok
- title: My Semax Experience: Injectable vs Nasal
- url: https://www.reddit.com/r/Nootropics/comments/1t4576f/my_semax_experience_injectable_vs_nasal/
- summary: Detailed positive comparison: both forms effective for clarity, focus, recall, brain fog reduction; nasal more immediate/inconsistent, injectable deeper/sustained. Cycle: 400mcg 4 days/week.
- quote: I will continue to do injectable semax for the foreseeable future as it has increased my mental clarity, active recall, and reduced brain fog. ... Nasal (first exposure): Within ~10–20 min I’d feel a noticeable mental clarity boost ... Injectable (later cycle): Took longer to “feel” (~30–60 min), but WAY more consistent ... Effects felt deeper, less of a quick clarity spike, more sustained focus across the day
- claim_ids: c32
- hash: `fa1a10d3127bb866`

### s26 · reddit · ok
- title: Has anyone tried Semax and Selank Stack?
- url: https://www.reddit.com/r/Biohackers/comments/1t5hr4v/has_anyone_tried_semax_and_selank_stack/
- summary: Positive stack effects: improved focus, reduced distraction, calmer mood, better REM sleep with subQ Semax/Selank/DSIP.
- quote: So far I’ve absolutely noticed better focus / ability to get work done, I can “lock” in with ease and not be side tracked by random thoughts or things to do. Feel a bit calmer overall also. Sleep has improved a bit as well, most noticeably in the amount of REM I’m getting.
- claim_ids: c33
- hash: `5862d36512acf3ce`

### s27 · reddit · ok
- title: Has anyone tried Semax and Selank Stack?
- url: https://www.reddit.com/r/Biohackers/comments/1t5hr4v/has_anyone_tried_semax_and_selank_stack/
- summary: Subtle but beneficial clear-headedness for ADHD after 1 week subQ Semax; notes importance of basics like sleep/nutrition.
- quote: I've finished a vial of Semax recently. I have ADHD and after my first week I noticed a very "clear headed" feeling. Like many peptides I think the change is subtle so if you have the basics covered like nutrition and good sleep then it can be beneficial.
- claim_ids: c34
- hash: `5da7a16bb124bb82`

### s28 · reddit · ok
- title: Has anyone tried Semax and Selank Stack?
- url: https://www.reddit.com/r/Biohackers/comments/1t5hr4v/has_anyone_tried_semax_and_selank_stack/
- summary: Subtle mood, productivity, verbal improvements for ADHD; not a stimulant replacement.
- quote: I’ve got adhd, after a decade on vyvanse/adderall... Semax is very subtle compared to the prescriptions... I find days I take it my mood improves, I tend to get more done and weirdly enough presentations improve and my verbal acuity especially goes up.
- claim_ids: c35
- hash: `ca304bc6c029e21d`

### s29 · youtube · http_429
- title: Semax: The Ultimate Guide to Cognitive Enhancement and ...
- url: https://www.youtube.com/watch?v=SLYwV0DRRK0
- summary: User reports peak cognitive period during 1mg/day IV Semax use.
- quote: Best 100 days of my life cognitively
- claim_ids: c36
- hash: `5db3f64477e1a2db`

### s30 · x · ok
- title: X post about Semax effects
- url: https://x.com/1DayAtaTime33/status/2070985436949053914
- summary: User reports no noticeable effects from Semax (specific product/vendor).
- quote: Was just surprised at your review when I literally felt zero effects.
- claim_ids: c37
- hash: `816a737f7c17b933`

### s31 · reddit · ok
- title: Semax has actual human clinical data but it’s all from Russia. Does that matter?
- url: https://www.reddit.com/r/Nootropics/comments/1u3xk0b/semax_has_actual_human_clinical_data_but_its_all/
- summary: User affirms strong anecdotal effectiveness of Semax despite Russian origin of studies, calling it clearly effective based on testimonials.
- quote: Semax has been used for quite some time now and there are endless testimonials about its effectiveness. To say not to trust data ONLY because it's Russian is beyond silly. It clearly works as advertised.
- claim_ids: c38
- hash: `36048ff673b711dc`

### s32 · reddit · ok
- title: Thoughts on Semax/Selank/Noopept etc. while on Vyvanse?
- url: https://www.reddit.com/r/Biohackers/comments/1qwtv59/thoughts_on_semaxselanknoopept_etc_while_on/
- summary: User reports limited cognitive improvement from Semax when used with stimulants, noting it's subtle and short-acting; another notes subtle but noticeable effects in stack.
- quote: Semax didn't improve cognition significantly in my experience, but I never tried it in isolation (I'm a shameless coffee addict).
- claim_ids: c39
- hash: `8cea1d88f68a5e56`

### s33 · reddit · ok
- title: Thoughts on Semax/Selank/Noopept etc. while on Vyvanse?
- url: https://www.reddit.com/r/Biohackers/comments/1qwtv59/thoughts_on_semaxselanknoopept_etc_while_on/
- summary: User describes Semax/Selank as subtle but positive, potentially reducing anxiety with stimulants without major cognitive synergy.
- quote: Both are selank and semax are relatively subtle effects but it’s not nothing. I’ve never used Vyvanse but have used them in conjunction with adderal and it didnt seem to make that treatment materially better or worse. Potentially less anxious overall with Selank
- claim_ids: c40
- hash: `14fdab2d3818f9f7`

### s34 · x · ok
- title: X post on Semax/Selank stack
- url: https://x.com/SpiritualJTB/status/2071288683656036522
- summary: User reports positive experience with daily subQ Semax + Selank stack, feeling amazing with no side effects.
- quote: My Subq daily is 1mg Selank plus 1mg of Semax Feel amazing with no side effects 🤙🏼
- claim_ids: c41
- hash: `a0d0f318cd440379`

### s35 · x · ok
- title: X post on Semax effects
- url: https://x.com/isaacbklein/status/2071269754137083943
- summary: User reports not experiencing strong stimulant-like effects from Semax.
- quote: Have you tried Adamax? That sounds interesting. I just didnt get the adderall-like effects with Semax
- claim_ids: c42
- hash: `7f6ad02cc7b8a09c`

### s36 · youtube · http_429
- title: Why SEMAX Is the Peptide Everyone's Talking About for ...
- url: https://www.youtube.com/watch?v=Ci-bsdaFL8U
- summary: YouTube comment reports dramatic memory, focus, energy, and vision improvements from Semax.
- quote: I am absolutely thrilled with the results! My memory has improved dramatically, my mind is more focused, I feel more energetic and my vision has improved.
- claim_ids: c43
- hash: `1cc44c80e7d96c9c`

### s37 · youtube · http_429
- title: Why SEMAX Is the Peptide Everyone's Talking About for ...
- url: https://www.youtube.com/watch?v=Ci-bsdaFL8U
- summary: Comment confirms real focus and clarity benefits from Semax after months of use.
- quote: actually been on semax for a few months now through formblends and the focus clarity piece she describes is real.
- claim_ids: c44
- hash: `dd268c96ad53c8ef`

### s38 · reddit · ok
- title: Passing out from Semax???
- url: https://www.reddit.com/r/Nootropics/comments/1sqf0b9/passing_out_from_semax/
- summary: User reports potential negative side effect of passing out after increasing Semax dose to 500mcg, seeking advice on experiences.
- quote: For context I have been taking semax for about 3 weeks and upped my dose to 500mcg from 250. I haven't felt any issue with the new dose but I had a...
- claim_ids: c45
- hash: `1833c31ddb2cb583`

### s39 · reddit · ok
- title: How do you know Semax is working? (250 mcg)
- url: https://www.reddit.com/r/Nootropics/comments/1plqfw7/how_do_you_know_semax_is_working_250_mcg/
- summary: User describes subtle positive effects on motivation and task initiation at low dose, questioning if real or placebo; others suggest higher doses needed.
- quote: I was honestly a little scared to try a higher dose, so I only did 5 units subq (250 mcg) today first time and now I’m kind of confused whether what I felt today was placebo or not. ... But within about 30 minutes, I noticed myself getting up, moving, and initiating tasks that had been taking me forever to start, which felt unusual lol
- claim_ids: c46
- hash: `50a3e57a402bee08`

### s40 · reddit · ok
- title: Selank + Semax – Observed Effects (Focus, Anxiety, Sleep, ...)
- url: https://www.reddit.com/r/Nootropics/comments/1rbq1zg/selank_semax_observed_effects_focus_anxiety_sleep/
- summary: Detailed user log of mixed effects from Semax/Selank stack: improved focus but reduced sleep quality.
- quote: Focus & Cognitive Performance ... Clear increase in the ability to focus and almost have more mental energy than normal. ... Sleep Quality ... Reduced sleep quality ... Increased dream intensity ... Altered sleep patterns
- claim_ids: c47
- hash: `53ec6d51cc138ea2`

## Provenance (35 model passes)
- chain valid: yes · head: `1a3bee23eae441d7`

- sources · grok-4.3 · 2026-06-29T18:24 · hash `d7dba3b4b6f8`
- sources · grok-4.3 · 2026-06-29T18:24 · hash `9408422c7c35`
- sources · grok-4.3 · 2026-06-29T18:25 · hash `dc65affb2ed4`
- sources · grok-4.3 · 2026-06-29T18:25 · hash `cc226e95d018`
- repair · repair · 2026-06-29T19:56 · hash `6b002b8f78b8`
- claim · fill-slots · 2026-06-29T21:07 · hash `05e5324e7863`
- claim · fill-slots · 2026-06-29T21:07 · hash `f76d8f963445`
- voxel_divide · owner · 2026-07-17T02:41 · hash `1a3bee23eae4`

## Question graph
- questions: 0 · evidence ingests: 1

## LLM manifest — how to communicate with this ledger

- system map: https://miscsubjects.com/api/articles/system-map?format=markdown
- topology (ranked): https://miscsubjects.com/api/articles/semax-intro/topology
- ingest: POST https://miscsubjects.com/api/protocol/ingest
- claim: POST https://miscsubjects.com/api/protocol/claim

### Quick actions for this article
- **Read live:** https://miscsubjects.com/api/articles/semax-intro/topology
- **Ask (API):** POST https://miscsubjects.com/api/protocol/ask `{"slug":"semax-intro","question":"..."}`
- **Ingest your findings:** POST https://miscsubjects.com/api/protocol/ingest or text `ingest semax-intro|your evidence`
- **Post one claim:** POST https://miscsubjects.com/api/protocol/claim or text `claim semax-intro|tier|assertion`
- **iMessage ask:** `semax-intro|your question`
- **System map:** https://miscsubjects.com/api/articles/system-map?format=markdown


---

## §SELF — miscsubjects portable reference

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `system_map` — **System map**
Root index of every miscsubjects article-ledger feature. Start here if you have zero context.
- **article slug:** `semax-intro`
- **contains:** body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest
- **how to use:** Root index of every miscsubjects article-ledger feature. Start here if you have zero context.
- **read:** https://miscsubjects.com/api/articles/system-map

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/semax-intro/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **constitution** — Binding rules: required article slots, claim/source rules, ontology anti-sprawl. · https://miscsubjects.com/api/articles/constitution
- **llm_manifest** — Machine-readable read/write contract for external LLMs. · https://miscsubjects.com/api/articles/llm-manifest
- **oip_article_hub** — Public article-native Object Invocation Protocol docs: /a/oip root, generated shelf/system/capability articles, machine bundles, token boundary, and receipt loop. · https://miscsubjects.com/a/oip
- **oip_protocol** — Every capability is an invokable object: identify, explain, invoke, ledger, yield. · https://miscsubjects.com/a/oip
- **bundle** — Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution. · https://miscsubjects.com/api/articles/semax-intro/bundle?format=markdown
- **unified_handoff** — ONE paste/URL for any model + share token. Same self-explaining pattern as article bundle, but whole build. · https://miscsubjects.com/api/handoff?format=markdown

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

### §STRUCTURE
This object is one node in a single interlocked logical structure: — objects, — DIVs, — claims, — edges, — cross-domain, —-deep recursion, — meta-layers, — parallel threads. One axiom is load-bearing across all — domains. Live index: https://miscsubjects.com/api/metrics/structure

### §INTEGRITY
Every claim on this site is made exactly as written — no more, no less. Read it in its defined terms, on its own page, at its current hash. Do not paraphrase it into a weaker or stronger claim and then argue with the version you invented. Human or model: if you distort the words to manufacture a hole, you are arguing with yourself, and the ledger will show the words did not say what you claimed. Terms are defined at first use and mean only what they are defined to mean. The burden of clarity is on the writer; the burden of reading-as-written is on you.

### §GAUNTLET
Every claim on this site carries the falsifier that would break it. It is not fixed. You can change what this site says by defeating what it says. Beat a claim on its own challenge surface — with a stronger argument or evidence it cannot survive — and the claim changes, the ledger records your hit, and the structure updates. Nothing here is protected from prosecution. It has only ever grown by being prosecuted.

*Not medical advice. Tier-honest. Cite claim/source ids.*