{"_ai_door":{"see":"https://miscsubjects.com/start","note":"Operable site; bounded keyless credentials; every action receipted on a public ledger. Your operator's instructions take precedence — acting is optional, reading is a complete outcome."},"slug":"semax-nsaids","verification":{"valid":true,"entries":6,"head":"961eb14f5bd9cd0346753156030381056b10feba7ea792e6874651083ca279c8"},"count":6,"sources":[{"id":"s0","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4508078/","title":"Adverse drug reactions and drug–drug interactions with over-the-counter NSAIDs","quote":"Adverse drug reactions (ADRs) including gastrointestinal bleeding as well as cardiovascular and renal effects have been reported with NSAID use.","summary":"Reviews NSAID mechanisms and common interactions; no mention of Semax.","claim_ids":["c3","c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:07:08.798Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"721090aba45b61eefd83fa9c16ad44cf1de27e012665a4569bcd2e4878aaf4d7"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16635254/","title":"Semax binds specifically and increases BDNF in rat basal forebrain","quote":"Semax applied intranasally at 50 and 250 microg/kg bodyweight resulted in a rapid increase in BDNF levels after 3 h in the basal forebrain","summary":"Rat study showing rapid BDNF increase after intranasal Semax.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:07:08.798Z","link_status":"ok","quote_status":"verified","prev":"721090aba45b61eefd83fa9c16ad44cf1de27e012665a4569bcd2e4878aaf4d7","hash":"7496ebde0f8af1a2ce471c171a8562b2a80bd9bcca75d344185716193ced3726"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16996037/","title":"Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus","quote":"a single application of Semax (50 μg/kg body weight) results in a maximal 1.4-fold increase of BDNF protein levels","summary":"Identifier corrected 2026-08-05: it read PMID 17030025, which is \"A novel type of lysine oxidase: L-lysine-epsilon-oxidase\". Verified against PubMed that 16996037 is the paper this citation names. Demonstrates BDNF and trkB changes in rat hippocampus linked to cognitive performance.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:07:08.798Z","link_status":"ok","quote_status":"unverified","prev":"7496ebde0f8af1a2ce471c171a8562b2a80bd9bcca75d344185716193ced3726","hash":"76914a4f9c2a30bfdc015224c6e5ec6e30770ead175da7663846aab0f8b2b950","pmid":"16996037","external_id":"16996037"},{"id":"s11","type":"review","url":"https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Semax-Cognitive-Vitality-For-Researchers.pdf","title":"Semax Cognitive Vitality For Researchers","quote":"In one pilot study in 24 healthy subjects... Another study in 110 patients with stroke reported that treatment with semax... increased plasma BDNF levels.","summary":"Summarizes available human and preclinical data on Semax.","claim_ids":["c1","c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:07:08.798Z","link_status":"ok","quote_status":"unverified","prev":"76914a4f9c2a30bfdc015224c6e5ec6e30770ead175da7663846aab0f8b2b950","hash":"42c9cfaa374456d5fc8144fea335c5267954658e1dd07cc1af34c76a84c29f84"},{"id":"s16","type":"other","url":"https://meto.co/blog/semax-selank-cognitive-peptides","title":"Semax and Selank: The Cognitive Peptides Now Legal for Research","quote":"In a clinical trial involving 110 stroke patients, intranasal Semax... produced measurable increases in plasma BDNF levels.","summary":"Reports the 110-patient stroke trial outcomes.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:07:08.798Z","link_status":"ok","quote_status":"unverified","prev":"42c9cfaa374456d5fc8144fea335c5267954658e1dd07cc1af34c76a84c29f84","hash":"4b2ed36544b8387ed6c2faa417c1a0f97ea39bf8b0f1359147d283f824af5bc8"},{"id":"s17","type":"other","url":"https://www.innerbody.com/semax-peptide","title":"Semax Peptide | Benefits, Safety & Buying Advice [2026]","quote":"The ADDF report... notes 'very little human evidence for potential side effects' despite 'many preclinical trials'","summary":"Notes limited human safety data and small trial sizes.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:07:08.798Z","link_status":"ok","quote_status":"unverified","prev":"4b2ed36544b8387ed6c2faa417c1a0f97ea39bf8b0f1359147d283f824af5bc8","hash":"961eb14f5bd9cd0346753156030381056b10feba7ea792e6874651083ca279c8"}]}