## §SELF — miscsubjects portable reference

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `article_bundle` — **LLM article bundle**
Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.
- **article slug:** `semax`
- **contains:** body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest
- **how to use:** Reference block for Grok/GPT/Gemini. Section §SELF explains the system.
- **read:** https://miscsubjects.com/api/articles/semax/bundle?format=markdown

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/semax/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **topology** — Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER. · https://miscsubjects.com/api/articles/semax/topology
- **voxels** — Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance. · https://miscsubjects.com/api/articles/semax/voxels
- **ask** — Answer only from topology; creates question_node with gaps and ingest_hint. · https://miscsubjects.com/api/articles/semax/prompts
- **ingest** — Parse pasted evidence → source ledger + claims + evidence_ingest node.
- **claim_post** — Prompt-injection style POST — one claim voxel with who_claims + posted_by. · https://miscsubjects.com/api/articles/semax/voxels
- **llm_manifest** — Machine-readable read/write contract for external LLMs. · https://miscsubjects.com/api/articles/llm-manifest

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

### §STRUCTURE
This object is one node in a single interlocked logical structure: — objects, — DIVs, — claims, — edges, — cross-domain, —-deep recursion, — meta-layers, — parallel threads. One axiom is load-bearing across all — domains. Live index: https://miscsubjects.com/api/metrics/structure

### §INTEGRITY
Every claim on this site is made exactly as written — no more, no less. Read it in its defined terms, on its own page, at its current hash. Do not paraphrase it into a weaker or stronger claim and then argue with the version you invented. Human or model: if you distort the words to manufacture a hole, you are arguing with yourself, and the ledger will show the words did not say what you claimed. Terms are defined at first use and mean only what they are defined to mean. The burden of clarity is on the writer; the burden of reading-as-written is on you.

### §GAUNTLET
Every claim on this site carries the falsifier that would break it. It is not fixed. You can change what this site says by defeating what it says. Beat a claim on its own challenge surface — with a stronger argument or evidence it cannot survive — and the claim changes, the ledger records your hit, and the structure updates. Nothing here is protected from prosecution. It has only ever grown by being prosecuted.

*Not medical advice. Tier-honest. Cite claim/source ids.*

---

# miscsubjects article bundle

> Reference bundle for Grok, GPT, Gemini, or a human reader. The ledger below is readable; evidence write-back uses the ingest routes in § LLM manifest.

## MASTHEAD
- **identity:** `semax` v49 · content_hash `5df794fc90e087d3…` · thread_head obj-299 · 11 DIVs
- **thesis (c1):** In rat hippocampus, a single intranasal dose of Semax (50 μg/kg) produced a maximal 1.4-fold increase in BDNF protein levels, accompanied by increased trkB phosphorylation and mRNA expression.
  - c2 [human/active] In a study of 110 patients after ischemic stroke, Semax increased plasma BDNF levels.
  - c6 [human/active] 2026 review mentioning Semax in context of neuroactive peptides for orthopaedics.
  - c10 [human/active] 2018 study using resting-state fMRI on healthy volunteers showing Semax increases volume in the rostral default mode network subcomponent compared to placebo.
  - c13 [human/active] Alzheimer's Drug Discovery Foundation researcher summary of available evidence on Semax for cognition, noting Russian use in stroke and limited healthy-subject 
  - c42 [human/active] Review of therapeutic peptides including Semax for neuroprotection in aging/gerontology contexts.
  - c44 [human/active] Reviews what is known about Semax safety, whether it works, and what doses are used.
  - c53 [human/active] June 2026 article reviewing Semax evidence for ADHD, noting limited human data and mechanisms like BDNF and dopamine.
- **sorry-status:** planes not merged yet — sorry-status activates after voxel-merge-planes
- **standing objections:** 2 open · strongest: MATERIAL: Honest that human data are small, mostly Russian, and that no large RCT settles focus/memory/concussion claims common in US grey-m → https://miscsubjects.com/api/articles/semax/discourse
- **verbs:** read free · challenge/attest open · edit/move/consolidate CAS-gated with a rows:VOXEL_* key
- **reads_next:** https://miscsubjects.com/a/philosophy · https://miscsubjects.com/api/articles/semax/discourse · https://miscsubjects.com/api/protocol

## Article
- **slug:** `semax`
- **title:** Semax: a Russian stroke drug sold as a focus spray, and what its numbers actually show
- **url:** https://miscsubjects.com/a/semax
- **register:** source_ledger
- **updated:** 2026-08-04T22:47:09.408Z
- **tags:** peptide, semax

## Body

Semax is a seven-amino-acid peptide that has been a registered medicine in Russia since the early 1990s, given in hospitals after a stroke and after a head injury. It is sold in the United States as a nose spray or a vial of powder, and bought for focus, memory and recovery from concussion. Two things about the evidence are true at the same time. There is human data — a 110-patient stroke study that measured a growth factor in the blood, a 24-person brain-imaging study in healthy volunteers, and an 11-person attention test — and every one of those studies is small, most are Russian, and not one of them was a large randomised trial of the kind that settles a question. The animal work is where the mechanism was actually pinned down, including a 2025 mouse study of a crushed spinal cord that is the closest thing in the literature to a nerve-injury result.

The site you are reading this on is funded by a business that sells this peptide. That is a commercial interest, and it is the reason the numbers below carry their limits with them instead of being rounded up.

## A stroke drug from Moscow, sold in America as a focus spray

Semax was built at the Institute of Molecular Genetics in Moscow from a fragment of ACTH, the hormone your pituitary releases under stress. ACTH has two jobs: it tells the adrenal gland to make cortisol, and it acts directly on brain tissue. The Moscow group cut the molecule down to the part that acts on the brain and threw away the part that drives cortisol. What is left is four amino acids of ACTH — positions 4 to 7 — with three more stuck on the end.

In Russia it is on the list of essential medicines and it is given for stroke, brain injury, optic nerve damage and, in children, attention problems. In the United States it has never been submitted to the FDA for review, so it is not an approved drug for anything. The Wikipedia entry and the vendor pages agree on this history; the disagreement is entirely about what the history proves.

That gap between forty years of clinical use in one country and near-zero regulatory footprint in another is the single most important fact about Semax, and it cuts both ways. Russian hospital use is real evidence that thousands of people have taken it without an obvious safety disaster. It is not evidence that it works, because most of that use was never tested against a placebo in a trial anyone outside Russia can read.

## Seven amino acids, and the last three exist only to stop your body eating it

The sequence is Met-Glu-His-Phe-Pro-Gly-Pro. The first four letters are the piece of ACTH that acts on brain tissue. The last three — proline, glycine, proline — do nothing on their own. They are there because a bare four-amino-acid peptide is chewed up by enzymes in the blood within seconds. The tail slows that down.

This matters for two practical reasons. First, it explains why the nose route dominates: sprayed into the nose, part of the dose reaches brain tissue along the olfactory route without having to survive a trip through the liver. Second, it explains why an even more protected version exists. N-acetyl Semax amidate — sold as NA-Semax — has a chemical cap on each end, lasts longer, and is a different product with a different dose response. People who report switching to it consistently report a longer effect, and one person reported their thinking got worse on it. Treating the two as interchangeable is the most common mistake in the self-reported record.

## The signal it pulls: one growth factor, and the receptor it docks into

The mechanism claim rests on one growth factor. Brain-derived neurotrophic factor, or BDNF, is the protein nerve cells use to grow new connections, keep existing ones alive, and rebuild after damage. It works by docking into a receptor on the cell surface called TrkB. When BDNF binds TrkB, the receptor switches on and starts a chain of signals inside the cell that ends in new protein being built at the synapse.

Injured nerve tissue runs short of this signal. After a stroke, a concussion or a crushed nerve, BDNF levels in the affected region drop, and the cells that survive have fewer resources to rebuild connections. Chronic stress does the same thing more slowly: in rats under weeks of unpredictable stress, hippocampal BDNF falls, adrenal glands enlarge, and the animals stop seeking things they used to like.

Semax raises that signal. That is the whole mechanistic case, and the numbers behind it are specific.

## One rat spray, four numbers, and the whole mechanism case

The 2006 study by Dolotov and colleagues is the load-bearing measurement. A single dose of Semax sprayed into a rat's nose, 50 micrograms per kilogram of body weight, produced in the hippocampus:

- BDNF protein up 1.4-fold
- TrkB receptor switched on — phosphorylation up 1.6-fold
- BDNF messenger RNA (exon III) up 3-fold
- TrkB messenger RNA up 2-fold

Four numbers from one dose in one brain region. The same group found BDNF protein rising in the basal forebrain too. Every claim you will read about Semax and neuroplasticity traces back through this measurement or a close relative of it.

Scale it honestly. A 1.4-fold rise in a protein is a real biological effect and a modest one. It is not a switch being thrown; it is a dial being turned. Whether turning that dial by 40 per cent for a few hours changes how a person thinks or heals is exactly the question the human studies were too small to answer.

Other animal work fills in the picture around it. A 2025 rat study found Semax changes which genes for neurotrophic factors are switched on, and that it stirs the dopamine and serotonin systems. A 2017 rat study looking across all biological processes found the immune response was the process most changed by the peptide, which nobody has followed up properly in people. A 2024 study in rats under chronic unpredictable stress found Semax reversed or blunted three separate consequences of that stress: the loss of interest in rewards, the enlargement of the adrenal glands, and the fall in hippocampal BDNF. In a mouse model of Alzheimer's disease, Semax and a derivative improved performance on three separate tests — open field, novel object recognition, and the Barnes maze.

There is also a chemistry finding that has nothing to do with BDNF. Semax grabs copper ions, and in artificial membrane models it interferes with the way copper-bound amyloid beta assembles into fibres. That is a test-tube result about a molecule, not a result about a brain.

The counter-example is worth as much as the wins. A 2025 review of Semax in Parkinson's models found the results inconsistent across different rat models, found that low doses did not improve movement problems, and noted that no clinical trial has ever tested it in people with Parkinson's.

## The mouse with a crushed spinal cord is the closest thing to a nerve-injury result

A 2025 paper in the British Journal of Pharmacology took female mice with spinal cord injuries and gave them Semax. Recovery of function improved. The mechanism the authors traced was not BDNF. It ran through the gene for the mu opioid receptor, Oprm1: Semax kept a protein in that pathway from being tagged for destruction, which in turn shut down a form of inflammatory cell death — cells rupturing and spilling their contents, which recruits more inflammation and kills the neighbours.

For anyone reading this because of a damaged nerve rather than a foggy morning, this is the study that matters most, and its limits need saying in the same breath. It is mice. It is one paper. The injury was a surgical crush to the cord under laboratory conditions. And the pathway it found is not the pathway the marketing talks about.

## What has actually been measured in people: 24 healthy volunteers and 110 stroke patients

Two human studies carry the weight.

The brain-imaging pilot. Twenty-four healthy people were given a 1 per cent Semax solution into the nose, 1.2 milligrams in total, or a placebo. Resting brain scans showed a larger signal in the front-midline part of the default mode network — the set of regions that stay active when you are not doing a task — in the Semax group. A related study found the volume of that same front region larger in the Semax group. This is a real, placebo-controlled measurement in people. It measures a brain signal, not a thought, and nothing about it tells you whether a person performed better.

The stroke study. One hundred and ten patients recovering from an ischaemic stroke were given Semax in two ten-day courses at 6,000 micrograms a day with a twenty-day gap between them. Plasma BDNF rose and stayed up for the length of the study, regardless of whether rehabilitation had started early or late. Patients with higher BDNF had better movement scores and better Barthel index scores, which is the standard measure of how much of daily life a person can manage alone.

Read that last sentence carefully, because the sentence that gets written about it in marketing copy is a different sentence. The study measured a protein in the blood and found it correlated with recovery. It did not show that Semax caused the recovery. The peptide raised BDNF; better BDNF went with better outcomes; the causal step between them was not tested.

## Eleven people, tired, doing an attention test

The third human data point is the smallest and the most honest about itself. Eleven healthy participants were tested on selective attention and short-term memory, with the effect showing up mainly under fatigue. Eleven people is a pilot. It is quoted widely as evidence Semax sharpens cognition in healthy adults; what it supports is that somebody should run the study properly.

One physician who reviewed the whole set publicly graded it: D+ for the focus and nootropic claims, C- for the stroke and blood-vessel evidence. That grade is one person's judgement, not a measurement, and it lands close to where the numbers above sit.

## Forty-three people wrote down what happened, and the split is wide

Sixty-eight self-reported sources were collected for this page from Reddit, X, YouTube and Instagram. Twenty-five of them are explainers, vendor posts, dosing questions, guides, news items or general commentary that report no personal outcome, so they are not counted here. Forty-three describe what happened to a specific person.

Of those 43: 22 reported a benefit, 10 reported a benefit that came with a cost or faded, 4 reported nothing at all, and 7 reported harm as their main experience.

This is a self-reported record. Nobody was blinded, nobody was randomised, the people who felt nothing are less likely to write a post than the people who felt transformed, and several accounts describe taking Semax alongside Selank, stimulants or other peptides, which makes the cause of any single report unclear. It is worth counting anyway, because it is the only large body of information about what happens when this compound is taken by people outside a hospital, and because the split it shows — roughly half clear benefit, a quarter benefit-then-problem, a sixth harm — is not the split the sales pages describe.

### The 22 who said it worked

The strongest reports are about mental performance under load, not mood. One person doing eight weeks on, eight weeks off wrote that at work "I perform so much better at high level mental tasks... my recall and articulation are noticeably improved." Another, after finishing a bottle of the 0.1 per cent spray, described fixing long-standing focus and memory problems and feeling, months later, "like I upgraded."

Speed of onset comes up repeatedly. One person on X described visual sharpness and mental clarity arriving "within just a few minutes," lasting from 8:30 in the morning until about 2 in the afternoon, with no crash. Another reported the room going quieter and "less friction between my thoughts and my work," again with no spike and no crash. One person taking 250 micrograms noticed within about thirty minutes that they were starting tasks that had been sitting for weeks.

Two reports are about damage rather than performance. A person in a traumatic brain injury forum wrote that after a couple of weeks on the nose spray they "did get some memory back." A person with epilepsy wrote that they remember more from the days they take it, focus better, and noticed their speech improving.

Two reports are about dose-finding rather than the drug. One person moved from 200 to 500 to 700 micrograms a day under the skin, found the effect only arrived at the higher end, and has held at 700 for two months. Another compared routes directly: the nose was faster but weaker, the needle took 30 to 60 minutes and was "WAY more consistent."

### The 10 who got a result and then lost it

This group is the most informative and the least quoted. The pattern is a strong first response followed by tolerance, a flat mood, or a cost that outweighed the benefit.

Tolerance is the commonest version. One person: "the effect only lasts about 2 weeks, 3 at best before you have to cycle it off." Another, injecting two peptides daily, described "amazing clean focused energy" that faded so fast that at 2 milligrams of each "it was doing nothing," and stopped. A third ran 600 micrograms of nose spray daily for two to three months, called the drive and curiosity it produced remarkable, and in the same post described feeling detached from their surroundings.

Emotional flattening is the second version. One person on about 1 milligram under the skin for a few months got real relief from focus problems, energy and fatigue-driven low mood, then "started to get emotionally blunted" badly enough that it affected their relationship. Another reported hair loss alongside an effect they otherwise liked.

The short-window version: one person felt their senses sharpen for fifteen minutes and then crash into tiredness. Another described strong focus that was "useless past early afternoon or I can't sleep."

### The 4 who felt nothing

Four accounts report no effect. "I literally felt zero effects." "I just didn't get the adderall-like effects." One person tried up to 1 milligram and rated it 6 out of 10, saying it helps "a little." One tried it daily, found the side effects acceptable, and stopped because something else worked better.

### The 7 who got worse, and the pattern in what went wrong

Seven reports are primarily about harm, and they cluster into four kinds.

Headache. Two people: one woke after a first-ever dose "extremely groggy and tired" with a headache most of the day; one wrote that the only thing they get from Semax is a migraine.

Crashing fatigue. One person, one spray at 6 a.m., described fatigue arriving around noon "as if I drank all night and then woke up with no sleep," and called it intense.

Low mood. One person taking 200 micrograms under the skin reported getting moody and feeling down on it.

Hair loss and worse thinking. One person reported two 30-day runs followed by a year of hair loss. One reported that on the N-acetyl amidate version "the quality of my cognition has declined since starting."

One further report describes passing out after moving from 250 to 500 micrograms, with the poster noting the higher dose had otherwise felt fine. A single fainting episode in a self-reported record is not a rate. It is the kind of event that would be caught in a trial and has not been.

The theme worth extracting: the reported harms are nearly all central nervous system effects on the same axis as the reported benefits — arousal, mood, sleep — which is what you would expect from something that acts on brain signalling rather than an off-target effect somewhere else in the body. The two hair-loss reports are the exception and have no counterpart anywhere in the published literature.

## What the tolerance reports mean if you are planning to take it for months

Tolerance appears in the self-reported record and nowhere in the published studies, because the published studies are short. The Russian stroke schedule is instructive on its own terms: two ten-day courses with a twenty-day gap. That is a cycled protocol designed by people giving the drug in hospitals, and it looks nothing like the daily indefinite use most self-reported accounts describe. Whether the gap is there because of tolerance, cost, or hospital practice is not documented in the material available here.

## Nose spray against a needle, and the doses people actually use

Published human doses: 1.2 milligrams total, into the nose, in the imaging pilot. 6,000 micrograms a day for ten days in the stroke study. That upper figure is five times what almost anyone in the self-reported record takes.

The doses people report using: 200 to 800 micrograms a day into the nose, or 250 micrograms to 1 milligram a day under the skin. Two strengths of nose spray circulate, 0.1 per cent and 1 per cent, and confusing them is a ten-fold error. One person in the record misread two bottles and took far more than intended.

Route changes the shape of the response, consistently across accounts. Nose: faster, weaker, shorter. Needle: slower to arrive, steadier, longer. That pattern is what you would expect from where each route delivers the peptide, and it is reported often enough to be worth planning around.

## Where it stands with the FDA after the April 2026 list change

Semax is not an approved drug in the United States and has never been submitted for approval.

The compounding position changed in 2026 and the change is widely misdescribed. The FDA's revised 503A bulk substances document, published 15 April 2026, removed Semax — both the free base and the acetate salt — from Category 2, the list of substances flagged with significant safety concerns. Removal from Category 2 is not permission. It moved the substance into a review process: the Pharmacy Compounding Advisory Committee took up Semax-related bulk drug substances at its meeting on 24 July 2026, alongside Epitalon and several others.

So the accurate statement is that Semax sits between lists. It is not on the approved bulks list, and it is no longer flagged in Category 2. Any page telling you the FDA banned it, and any page telling you the FDA cleared it, is describing a document that does not exist.

## What a serious test would look like, and why nobody has run one

The study that would settle the focus question is not exotic: two hundred healthy adults, randomised, placebo-controlled, one dose into the nose, a standard attention battery, and a measurement of the same brain signal the 24-person pilot found. The study that would settle the peripheral-nerve question is harder and more valuable, because every measurement in this literature was taken in brain tissue and none in a peripheral nerve: an animal model of peripheral nerve injury, with nerve conduction and recovery measured against untreated controls.

Neither has been run, and the reason is structural rather than scientific. The molecule is decades old and unpatentable in its original form, the Russian clinical record does not translate into a US filing, and the American market for it works fine without a trial. That is a commercial fact about the compound, not a fact about whether it works — and it is the reason the honest version of this page has to stop where it does.

## Every source behind the numbers above, and how to pull them

Thirty-four published sources are attached to this page: 13 indexed studies, 7 reviews, 12 clinical or regulatory pages, 1 news item, and the encyclopaedia entry. Sixty-eight self-reported sources are attached, of which 43 are counted above with the platform, the quote and the date on each card. Every number in this page traces to one of them, and the cards are on this page rather than in a bibliography so that a claim and the thing it rests on can be read together.


## Claims (48 of 103 ranked)

- **c112** [mechanistic w=0.3] Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
  - who_claims: miscsubjects protocol
  - slot: limitations
- **c2** [human w=0.8] In a study of 110 patients after ischemic stroke, Semax increased plasma BDNF levels.
  - who_claims: system/repair
  - slot: mechanism
  - sources: s2
- **c6** [human w=0.8] 2026 review mentioning Semax in context of neuroactive peptides for orthopaedics.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s5
- **c10** [human w=0.8] 2018 study using resting-state fMRI on healthy volunteers showing Semax increases volume in the rostral default mode network subcomponent compared to placebo.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s9
- **c42** [human w=0.8] Review of therapeutic peptides including Semax for neuroprotection in aging/gerontology contexts.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s41
- **c53** [human w=0.8] June 2026 article reviewing Semax evidence for ADHD, noting limited human data and mechanisms like BDNF and dopamine.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s52
- **c61** [human w=0.8] Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
  - who_claims: system/protocol
  - slot: disclaimer
- **c1** [preclinical w=0.5] In rat hippocampus, a single intranasal dose of Semax (50 μg/kg) produced a maximal 1.4-fold increase in BDNF protein levels, accompanied by increased trkB phosphorylation and mRNA expression.
  - who_claims: system/repair
  - slot: mechanism
  - sources: s1
- **c23** [preclinical w=0.5] 2024 study showing Semax exerts antidepressant-like effects in a chronic unpredictable stress rat model, reversing anhedonia and restoring hippocampal BDNF levels.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s22
- **c62** [preclinical w=0.5] There is a lack of longitudinal studies examining the long-term effects of Semax on BDNF levels and cognitive function.
  - who_claims: kimi-collaborator
  - slot: what_is_unknown
  - sources: s1
- **c67** [preclinical w=0.5] 2024 study using RNA-Seq showing Semax and related peptide compensate gene expression changes from ischemia in rat brain at 24h post-stroke, affecting immune, neurosignaling, neurogenesis, and angiogenesis pathways.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s59
- **c111** [runtime w=0.35] Semax: BDNF Upregulation is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.
  - who_claims: miscsubjects protocol
  - slot: what_it_is
- **c66** [mechanistic w=0.3] 2020 study examining Semax (with Selank) effects on brain functional connectivity via fMRI.
  - who_claims: grok-4.3
  - slot: what_is_known
  - sources: s58
- **c40** [anecdotal w=0.3] Positive acute effects on focus/anxiety but tolerance develops after 2-3 weeks requiring cycling.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s39
- **c68** [anecdotal w=0.3] User reports strong positive focus boost for short periods but notes it interferes with sleep if used later in the day.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s60
- **c69** [anecdotal w=0.3] Negative experience: only migraine reported, calls it overrated.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s61
- **c70** [anecdotal w=0.3] Neutral to positive: minimal side effects in trial, switched to as-needed use.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s62
- **c74** [anecdotal w=0.3] User reports feeling amazing with no side effects from daily subQ 1mg Semax + 1mg Selank.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s66
- **c85** [anecdotal w=0.3] User reports severe negative outcome after two 30-day periods of Semax use, lasting effects for a year.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s77
- **c86** [anecdotal w=0.3] User calls Semax their saving grace recently.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s78
- **c88** [anecdotal w=0.3] User reports no Adderall-like effects from Semax.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s80
- **c92** [anecdotal w=0.3] User liked Semax effects but reported hair loss as a negative outcome.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s84
- **c93** [anecdotal w=0.3] Mixed/negative on Semax (minimal effect even at 1mg), positive on Selank for deep sleep.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s85
- **c94** [anecdotal w=0.3] Initial positive effects on focus and calm but rapid tolerance build-up with daily injectable use.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s86
- **c100** [anecdotal w=0.3] X post discussing Semax + Selank stack for cognitive benefits in high-performance contexts (anecdotal context).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s92
- **c101** [anecdotal w=0.3] X post anecdotal daily dosing of 1mg Semax + 1mg Selank (anecdotal, not advice).
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s93
- **c102** [anecdotal w=0.3] X post grading Semax evidence levels in context of potential compounding discussions.
  - who_claims: grok-4.3
  - slot: who_claims_what
  - sources: s94
- **c13** [human w=0.8] Alzheimer's Drug Discovery Foundation researcher summary of available evidence on Semax for cognition, noting Russian use in stroke and limited healthy-subject data.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s12
- **c44** [human w=0.8] Reviews what is known about Semax safety, whether it works, and what doses are used.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s43
- **c4** [preclinical w=0.22] 2025 study showing Semax improves cognitive functions in transgenic Alzheimer's disease mouse model.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s3
- **c5** [preclinical w=0.22] 2025 study on Semax for spinal cord injury recovery in mice.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s4
- **c29** [mechanistic w=0.3] 2025 study on Semax as copper chelator and potential in neurodegenerative disorders.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s28
- **c31** [mechanistic w=0.3] 2025 study on Semax effects on calcium fluctuations in neurons.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s30
- **c52** [mechanistic w=0.3] 2007 hypothesis paper proposing Semax for ADHD and Rett syndrome based on its mechanisms.
  - who_claims: grok/grok-4.3
  - slot: what_is_known
  - sources: s51
- **c64** [mechanistic w=0.3] 2022 study showing Semax interferes with copper-induced amyloid beta aggregation, relevant to Alzheimer's.
  - who_claims: grok-4.3
  - slot: mechanism
  - sources: s56
- **c8** [anecdotal w=0.3] User anecdote on improved focus, memory, and performance with Semax nasal spray.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s7
- **c9** [anecdotal w=0.3] YouTube video discussing Semax benefits for cognition.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s8
- **c14** [anecdotal w=0.3] 2026 Reddit user anecdote comparing nasal vs subQ injectable Semax, reporting better consistency and sustained focus with injectable at 400mcg/day 4 days/week.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s13
- **c15** [anecdotal w=0.3] Multiple user anecdotes on long-term or post-use effects of Semax, with reports of lasting cognitive improvements or benefits persisting after cessation.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s14
- **c16** [anecdotal w=0.3] User reports positive experience with Semax for brain fog and cognitive issues.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s15
- **c17** [anecdotal w=0.3] TBI patient reports memory improvement and reduced brain fog with Semax nasal spray and amidate version; positive long-term feel.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s16
- **c18** [anecdotal w=0.3] User reports initial overstimulation followed by grogginess, headache, and fatigue after high first dose of nasal Semax; comments include positive subq experiences and vision side effect report.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s17
- **c19** [anecdotal w=0.3] Mixed user reports: some positive focus/ADHD benefits and longer lasting with NA version; others subtle or no effect from stack.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s18
- **c20** [anecdotal w=0.3] Neuroscientist user reports acute mental clarity, visual sharpness, smooth nootropic effect lasting hours without crash on first day of Semax.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s19
- **c21** [anecdotal w=0.3] User reports strong cognitive benefits, clean focus, BDNF upregulation feel, 24h activity from nasal spray, pairs well with others.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s20
- **c22** [anecdotal w=0.3] Video review of personal Semax trial including benefits experienced and reasons for stopping use.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s21
- **c24** [anecdotal w=0.3] 2026 video by Dr. Debra Durst explaining Semax (referred to as CAX) mechanisms via BDNF and neuroplasticity for focus, learning, and mental clarity without stimulant effects.
  - who_claims: grok/grok-4.3
  - slot: mechanism
  - sources: s23
- **c27** [anecdotal w=0.3] User discussion on Semax nasal spray concentrations, with comments recommending 0.1% for nootropic use in healthy people and 1% for stroke/TBI recovery, including dosing advice from Russian sources.
  - who_claims: grok/grok-4.3
  - slot: who_claims_what
  - sources: s26

## Voxel graph (103 atoms · 207 edges)
- full graph: https://miscsubjects.com/api/articles/semax/voxels

## Article constitution

- full: https://miscsubjects.com/api/articles/constitution

## Source ledger (40 of 102)
- chain valid: yes · head: `4db8b169bb6f3e31`

### s1 · pubmed · ok
- title: Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
- url: https://pubmed.ncbi.nlm.nih.gov/16996037/
- summary: 2006 rat study showing Semax increases hippocampal BDNF and trkB.
- quote: Here, we found that a single application of Semax (50 microg/kg body weight) results in a maximal 1.4-fold increase of BDNF protein levels accompanying with 1.6-fold increase of trkB tyrosine phosporylation levels, and a 3-fold and a 2-fold increase of exon III BDNF and trkB mRNA levels, respectively, in the rat hippocampus.
- claim_ids: c1, c62
- hash: `16ea6409cbc17a85`

### s2 · pubmed · ok
- title: The efficacy of semax in the treatment of patients at the early and late stages of rehabilitation after ischemic stroke
- url: https://pubmed.ncbi.nlm.nih.gov/29798983/
- summary: 2018 human study in 110 stroke patients showing Semax raises plasma BDNF.
- quote: Administration of semax, regardless of the timing of rehabilitation, increased BDNF plasma levels which remained high during the whole study period.
- claim_ids: c2
- hash: `5b145592beaab670`

### s3 · pubmed · ok
- title: The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease
- url: https://pubmed.ncbi.nlm.nih.gov/41479572/
- summary: 2025 study showing Semax improves cognitive functions in transgenic Alzheimer's disease mouse model.
- quote: The open field, novel object recognition, and Barnes maze tests demonstrated that both Semax and its derivative improved cognitive functions in mice .
- claim_ids: c4
- hash: `d736ddfba63aa97c`

### s4 · pubmed · ok
- title: Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice
- url: https://pubmed.ncbi.nlm.nih.gov/40692165/
- summary: 2025 study on Semax for spinal cord injury recovery in mice.
- quote: Semax improved SCI functional recovery and inhibited LMP-related pyroptosis in SCI mice and neuroinflammation models, by decreasing ...
- claim_ids: c5
- hash: `182e2de4e2eeb687`

### s5 · review · ok
- title: Therapeutic Peptides in Orthopaedics: Applications, ...
- url: https://pubmed.ncbi.nlm.nih.gov/41490200/
- summary: 2026 review mentioning Semax in context of neuroactive peptides for orthopaedics.
- quote: Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pinealon target circadian and mitochondrial regulators, and neuroactive peptides like selank, semax, and dihexa enhance brain-derived neurotrophic factor and HGF/c-Met pathways critical to neuroplasticity.
- claim_ids: c6
- hash: `c7b31485dc333eea`

### s6 · medical · ok
- title: The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease
- url: https://pmc.ncbi.nlm.nih.gov/articles/PMC12755871/
- summary: Full text of 2025 Acta Naturae paper on Semax in AD mouse model.
- quote: These findings demonstrate the high potential of Semax and its derivatives when used to develop therapeutic and corrective strategies for Alzheimer's disease.
- claim_ids: c7
- hash: `76b426f605dfd74a`

### s7 · reddit · ok
- title: My experience with semax an how it's helped me
- url: https://www.reddit.com/r/Nootropics/comments/1skhrm6/my_experience_with_semax_an_how_its_helped_me/
- summary: User anecdote on improved focus, memory, and performance with Semax nasal spray.
- quote: I do cycles of 8 weeks on, 8 weeks off, and when I take it I feel like a fucking computer- I perform so much better at high level mental tasks at work, and in meetings my recall and articulation are noticeably improved to where I outperform everyone else in the room.
- claim_ids: c8, c63
- hash: `ac073a5ece3f1fc0`

### s8 · youtube · http_429
- title: Why SEMAX Is the Peptide Everyone's Talking About for ...
- url: https://www.youtube.com/watch?v=Ci-bsdaFL8U
- summary: YouTube video discussing Semax benefits for cognition.
- quote: Discover how SEMAX can boost your memory, learning capability, and mental agility in this video.
- claim_ids: c9
- hash: `181eb03f68a5d25c`

### s9 · pubmed · ok
- title: Effects of Semax on the Default Mode Network of the Brain
- url: https://pubmed.ncbi.nlm.nih.gov/30225715/
- summary: 2018 study using resting-state fMRI on healthy volunteers showing Semax increases volume in the rostral default mode network subcomponent compared to placebo.
- quote: A greater volume of the default mode network rostral (medial frontal cortex) subcomponent was detected in the Semax group in comparison with controls. Resting state fMRI confirmed Semax effects on the neuronal network of the brain and demonstrated topography of these effects.
- claim_ids: c10
- hash: `3f6390fb94c14ea8`

### s10 · review · ok
- title: Semax for Parkinson's Neuroprotection: A Qualitative Literature Review
- url: https://scholarworks.utrgv.edu/colloquium/2025/posters/50/
- summary: 2025 qualitative review of rodent studies on Semax for Parkinson's-like models, noting anxiolytic effects but inconsistent motor benefits and lack of human PD trials.
- quote: While nearly all studies agree that Semax can improve anxiety, prior work on the effect of Semax with different types of PD-like rat models is inconsistent. ... low doses of Semax does not improve motor deficits in animal models and no clinical trials have tested its efficacy in human PD patients.
- claim_ids: c11
- hash: `a9e4699d8da41373`

### s11 · medical · ok
- title: Semax Peptide: Benefits, Safety & Buying Advice [2026]
- url: https://www.innerbody.com/semax-peptide
- summary: 2026 comprehensive review covering mechanisms, animal and limited human studies on Semax for cognition, neuroprotection, and mood.
- quote: In a paper for a 2017 study of Semax in rats, researchers claim that “the immune response is the process most markedly affected by the peptide”. ... A 2024 study of ACTH analogs in rodents showed that coadministration of Semax with another analog successfully reduced the severity of depressive symptoms and increased BDNF levels in the brain.
- claim_ids: c12
- hash: `c0ee899f9f5f077f`

### s12 · review · ok
- title: Semax Cognitive Vitality For Researchers
- url: https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Semax-Cognitive-Vitality-For-Researchers.pdf
- summary: Alzheimer's Drug Discovery Foundation researcher summary of available evidence on Semax for cognition, noting Russian use in stroke and limited healthy-subject data.
- quote: In one pilot study in 24 healthy subjects, intranasal 1% semax solution (total dose 1.2 mg) increased resting fMRI signal in the default mode network rostral subcomponent relative to placebo (Lebedeva et al, 2018). ... Another study in 110 patients with stroke reported that treatment with semax (2 courses 6000 µg/day for 10 days with 20-day interval) increased plasma BDNF levels.
- claim_ids: c13
- hash: `a0339976490c95b8`

### s13 · reddit · ok
- title: My Semax Experience: Injectable vs Nasal
- url: https://www.reddit.com/r/Nootropics/comments/1t4576f/my_semax_experience_injectable_vs_nasal/
- summary: 2026 Reddit user anecdote comparing nasal vs subQ injectable Semax, reporting better consistency and sustained focus with injectable at 400mcg/day 4 days/week.
- quote: TLDR: Both work really well for me, effects from nasal are more immediate but also more dampened. ... Injectable (later cycle): Took longer to “feel” (~30–60 min), but WAY more consistent ... increased my mental clarity, active recall, and reduced brain fog.
- claim_ids: c14
- hash: `e661f39667fb7178`

### s14 · reddit · ok
- title: Long term effects of Semax? Experiences?
- url: https://www.reddit.com/r/Nootropics/comments/14dhhr9/long_term_effects_of_semax_experiences/
- summary: Multiple user anecdotes on long-term or post-use effects of Semax, with reports of lasting cognitive improvements or benefits persisting after cessation.
- quote: I've completed 1 bottle of 0.1% semac, and this thing works wonders. I used to have focus issues, memory issues... About 3-5 months later. I felt like I upgraded, not mentally but physically also. I felt like I got my mind back.
- claim_ids: c15
- hash: `350c634428c8e055`

### s15 · reddit · ok
- title: Experience with Semax : r/Nootropics
- url: https://www.reddit.com/r/Nootropics/comments/17prmbj/experience_with_semax/
- summary: User reports positive experience with Semax for brain fog and cognitive issues.
- quote: Short Story: I'm a 25-year-old male who has been grappling with severe brain fog, speech difficulties, and struggles ...
- claim_ids: c16
- hash: `119d140d49b2f205`

### s16 · reddit · ok
- title: Semax nasal spray life changing have my memory back
- url: https://www.reddit.com/r/TBI/comments/1t25t3z/semax_nasal_spray_life_changing_have_my_memory/
- summary: TBI patient reports memory improvement and reduced brain fog with Semax nasal spray and amidate version; positive long-term feel.
- quote: I started taking semax a couple weeks ago. I did get some memory back. ... I’m now on Semax Amidate it lasts longer in system.
- claim_ids: c17
- hash: `2b262466fd4854f1`

### s17 · reddit · ok
- title: Semax side effects after one day : r/Nootropics
- url: https://www.reddit.com/r/Nootropics/comments/1rohx2j/semax_side_effects_after_one_day/
- summary: User reports initial overstimulation followed by grogginess, headache, and fatigue after high first dose of nasal Semax; comments include positive subq experiences and vision side effect report.
- quote: I took semax nasal spray for the first time ever yesterday. ... Today when I woke up I felt extremely groggy and tired. ... headache most of the day
- claim_ids: c18
- hash: `b9273c70659165e5`

### s18 · reddit · ok
- title: Has anyone tried Semax and Selank Stack? : r/Biohackers
- url: https://www.reddit.com/r/Biohackers/comments/1t5hr4v/has_anyone_tried_semax_and_selank_stack/
- summary: Mixed user reports: some positive focus/ADHD benefits and longer lasting with NA version; others subtle or no effect from stack.
- quote: So just an update: Semax worked well for me but have now started on NA Semax and it is far longer lasting. ... I did a combo intra-nasally for one month. Subtle, yet not enough change to warrant a second purchase.
- claim_ids: c19
- hash: `e04b7a04ac9a9e13`

### s19 · x · ok
- title: My first day using Semax
- url: https://x.com/BowTiedNeuron/status/1867370394078122275
- summary: Neuroscientist user reports acute mental clarity, visual sharpness, smooth nootropic effect lasting hours without crash on first day of Semax.
- quote: Within just a few minutes my visual acuity/sharpness increased and I felt a notable mental clarity set in ... This noticeable effect lasted from about 8:30am until around 2pm. There was no crash though
- claim_ids: c20
- hash: `705c5aec8c37614d`

### s20 · x · ok
- title: Semax peptide experience
- url: https://x.com/morellifit/status/2064010445636448703
- summary: User reports strong cognitive benefits, clean focus, BDNF upregulation feel, 24h activity from nasal spray, pairs well with others.
- quote: I've been using it for a few months and the cognitive benefits are insane. ... Within minutes, the room feels quieter, and there's less friction between my thoughts and my work. ... no spike and no crash
- claim_ids: c21
- hash: `7a4db8231afad957`

### s21 · youtube · http_429
- title: I Tried Semax... Here's What Happened!
- url: https://www.youtube.com/watch?v=owegYxCpkrk
- summary: Video review of personal Semax trial including benefits experienced and reasons for stopping use.
- quote: I'm excited to share my experience as you'll learn how Semax has helped me in the past, but also why I no longer use this cognitive supplement.
- claim_ids: c22
- hash: `697254f8bfb9a991`

### s22 · pubmed · ok
- title: Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress
- url: https://pubmed.ncbi.nlm.nih.gov/39442746/
- summary: 2024 study showing Semax exerts antidepressant-like effects in a chronic unpredictable stress rat model, reversing anhedonia and restoring hippocampal BDNF levels.
- quote: We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF.
- claim_ids: c23
- hash: `28c197f849a6be8c`

### s23 · youtube · http_429
- title: Why SEMAX Is the Peptide Everyone's Talking About for Focus Without Stimulants
- url: https://www.youtube.com/watch?v=RcLPGVY6lc0
- summary: 2026 video by Dr. Debra Durst explaining Semax (referred to as CAX) mechanisms via BDNF and neuroplasticity for focus, learning, and mental clarity without stimulant effects.
- quote: CAX is a regulatory peptide with neutropic effects... it actually can build and help you build new brain cells... particularly associated with some attention and focus enhancement, some mental stamina... works with what we call BDNF which is brain derived neurotrophic factor.
- claim_ids: c24
- hash: `4ea965941ea052a5`

### s24 · reddit · ok
- title: Semax has actual human clinical data but it's all from ...
- url: https://www.reddit.com/r/Nootropics/comments/1u3xk0b/semax_has_actual_human_clinical_data_but_its_all/
- summary: 2026 Reddit discussion highlighting existing Russian human clinical/observational data on Semax for stroke and cognitive issues.
- quote: So Semax has a solid body of human observational studies covering stroke recovery, cognitive impairment, and neuroprotection.
- claim_ids: c3
- hash: `d5257416d3f77a6b`

### s25 · medical · http_403
- title: Semax Peptide: Benefits, Dosage & Nasal Spray | Rite Aid
- url: https://riteaid.com/peptides/semax
- summary: Medical overview of Semax as a Russian-approved nootropic peptide, noting its 2026 FDA regulatory status changes for compounding, benefits for cognition and neuroprotection, and administration methods.
- quote: It is one of the 12 peptides the FDA removed from its Section 503A Category 2 list in April 2026, and one of seven peptides under formal advisory review on July 23–24, 2026.
- claim_ids: c26
- hash: `0a63064cfe9b6e51`

### s26 · reddit · ok
- title: Semax spray - 0.1% or 1%? And which dose?
- url: https://www.reddit.com/r/Nootropics/comments/maswyn/semax_spray_01_or_1_and_which_dose/
- summary: User discussion on Semax nasal spray concentrations, with comments recommending 0.1% for nootropic use in healthy people and 1% for stroke/TBI recovery, including dosing advice from Russian sources.
- quote: Isn't the 1% mainly for people suffering from a TBI or similar issues? Pretty sure they suggest to take the 0.1% for "normal" situations and take another dose 15 minutes later if needed.
- claim_ids: c27
- hash: `a4ba95f7d2a83c4d`

### s27 · review · ok
- title: The Effect of Peptide Semax, an ACTH(4-10) Analogue, on the Expression of Genes Encoding Neurotrophic Factors in the Rat Brain
- url: https://link.springer.com/article/10.1007/s10517-025-06501-z
- summary: 2025 review/paper on Semax effects on gene expression for neurotrophic factors in rat brain, referencing its nootropic and neurotransmitter-modulating properties.
- quote: Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.
- claim_ids: c28
- hash: `6485c555613b741f`

### s28 · pubmed · ok
- title: Semax, a Copper Chelator Peptide, Decreases the Cu(II) ...
- url: https://pubmed.ncbi.nlm.nih.gov/40496623/
- summary: 2025 study on Semax as copper chelator and potential in neurodegenerative disorders.
- quote: This study provides valuable insights into the potential role of Semax in neurodegenerative disorders and into the design of new compounds with ...
- claim_ids: c29
- hash: `90ce93be58125f82`

### s29 · medical · ok
- title: Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice
- url: https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.70122
- summary: 2025 research article on Semax effects on spinal cord injury recovery in mice via Oprm1.
- quote: Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice - Liu - 2025 - British Journal of Pharmacology
- claim_ids: c30
- hash: `8bfe169613197838`

### s30 · pubmed · ok
- title: The Effect of Peptide Semax, an ACTH(4-10) Analogue, on ...
- url: https://pubmed.ncbi.nlm.nih.gov/41171324/
- summary: 2025 study on Semax effects on calcium fluctuations in neurons.
- quote: We studied the effects of Semax on spontaneous fluctuations of intracellular calcium ion concentration [Ca 2+ ]i in pyramidal neurons ...
- claim_ids: c31
- hash: `4dcfaf938280ade3`

### s31 · reddit · ok
- title: What Semax actually is, and what the research really shows
- url: https://www.reddit.com/r/NTNPerformance/comments/1u17hpb/what_semax_actually_is_and_what_the_research/
- summary: 2026 Reddit post discussing Semax research and effects.
- quote: Semax gets sold online as a clean cognitive upgrade: more focus, more BDNF, a sharper brain on demand. The real picture is more interesting and a ...
- claim_ids: c32
- hash: `cf9f80f043ff00fe`

### s32 · youtube · http_429
- title: Semax Results (No One Talks About These Benefits)
- url: https://www.youtube.com/watch?v=p3GOtQmPPFo
- summary: 2025 YouTube video on Semax benefits for focus, memory, mental clarity.
- quote: Semax is a peptide that can boost focus, memory and mental clarity . Semax works in the brain by adjusting dopamine and BDNF pathways ...
- claim_ids: c33
- hash: `2cdf11dd0c1e30b4`

### s33 · medical · ok
- title: Semax Peptide Dosage Guide: Benefits, Safety & Best Practices
- url: https://www.helimeds.com/blog/semax-dosage
- summary: 2026 guide on Semax dosage, benefits, and FDA-related updates.
- quote: Semax dosage protocols often yield sharper concentration, faster processing speed, and reduced mental fatigue within 30–60 minutes.
- claim_ids: c34
- hash: `3cf9cd4fc0a9de71`

### s34 · reddit · ok
- title: Has anyone tried Semax nasal spray before ? This was my ...
- url: https://www.reddit.com/r/USPeptides/comments/1uflo0m/has_anyone_tried_semax_nasal_spray_before_this/
- summary: Positive user report on nasal Semax improving mental clarity and focus.
- quote: I've had a pretty good experience with Semax so far. I mainly noticed it seemed to help with mental clarity and focus without feeling ...
- claim_ids: c35
- hash: `4754c5a2569001f7`

### s35 · reddit · ok
- title: Semax effects on emotions : r/Nootropics
- url: https://www.reddit.com/r/Nootropics/comments/3q9h7a/semax_effects_on_emotions/
- summary: Initial good effects on focus/energy then negative emotional blunting from subQ Semax.
- quote: I experienced this to the point where it started to affect my relationship. I was taking 1mg sub-q for a few months with great effects: less ADD-related focus problems, more energy throughout the day, less fatigue-induced depression. After a while (not sure how long), I started to get emotionally blunted.
- claim_ids: c36
- hash: `bb27e11ae3a46786`

### s36 · reddit · ok
- title: Selank + Semax – Observed Effects (Focus, Anxiety, Sleep, ...
- url: https://www.reddit.com/r/Nootropics/comments/1rbq1zg/selank_semax_observed_effects_focus_anxiety_sleep/
- summary: Detailed positive observations on focus, reduced anxiety from Semax/Selank stack.
- quote: Focus & Cognitive Performance: Sustained attention, Improved task persistence, Enhanced cognitive engagement. Observation: Clear increase in the ability to focus and almost have more mental energy than normal. Anxiety: Reduced baseline anxiety.
- claim_ids: c37
- hash: `8a66aad3c1c79fd2`

### s37 · reddit · ok
- title: About to start Semax peptide : r/Epilepsy
- url: https://www.reddit.com/r/Epilepsy/comments/1mjseg2/about_to_start_semax_peptide/
- summary: Positive post-use report on improved memory, focus, and speech after seizures.
- quote: Update: it has helped immensely!!! I remember more from the days I take it, I’m focusing better, and I also noticed my speech improving!
- claim_ids: c38
- hash: `b4d3cbdf6dacb3ab`

### s38 · reddit · ok
- title: Semax giving me neutral and short-lived symptoms? What ...
- url: https://www.reddit.com/r/Nootropics/comments/wswq8x/semax_giving_me_neutral_and_shortlived_symptoms/
- summary: Mixed/neutral experience with short-lived sensory boost followed by tiredness/crash.
- quote: For 15 minutes, I feel like my external senses are turned more 'on' and I pay attention more to my surroundings... Then after 15 minutes, I crash and become tired for a few mins.
- claim_ids: c39
- hash: `4ec214bd2240722f`

### s39 · x · ok
- title: My take on Semax
- url: https://x.com/irvinnofficial/status/2070327711558750336
- summary: Positive acute effects on focus/anxiety but tolerance develops after 2-3 weeks requiring cycling.
- quote: My take on Semax: great compound, nice smooth focus and reduced anxiety. Unfortunately, the effect only lasts about 2 weeks, 3 at best before you have to cycle it off for a couple weeks.
- claim_ids: c40
- hash: `cdb66e56c93d45d1`

### s40 · x · ok
- title: Semax clarification
- url: https://x.com/morellifit/status/2070495687436050543
- summary: Personal daily use report emphasizing subjective positive cognitive effects.
- quote: This is just me experimenting on myself... This is my subjective experience. This is how Semax feels for me, taking it every single day.
- claim_ids: c41
- hash: `1302ae609ebf2311`

## Provenance (46 model passes)
- chain valid: yes · head: `a93328697298fa84`

- sources · grok-4.3 · 2026-06-29T17:31 · hash `d42af58833c8`
- sources · grok-4.3 · 2026-06-29T17:31 · hash `b582bd40cb16`
- sources · grok-4.3 · 2026-06-29T17:32 · hash `c8ba92e5962d`
- repair · repair · 2026-06-29T19:24 · hash `13563d57fa15`
- claim · fill-slots · 2026-06-29T20:38 · hash `9d021bf424d3`
- claim · fill-slots · 2026-06-29T20:38 · hash `1ffa83b6b81b`
- voxel_divide · owner · 2026-07-17T02:41 · hash `e7a1af785900`
- plain-language-claim-rewrite · opus-5 (claude-code) · 2026-08-04T21:15 · hash `a93328697298`

## Question graph
- questions: 3 · evidence ingests: 1
- **qn_cognitive_stack_adderall_insomnia_is_semax_safe__505764c2** [gap] Is Semax safe with Adderall?
  - gaps: No human interaction data; No long-term safety data on combination; Patient-specific factors (dose, timing, health conditions) unknown
- **qn_cognitive_stack_adderall_insomnia_is_semax_safe__fe00fad2** [gap] Is Semax safe with Adderall?
  - gaps: No human interaction trials; No long-term safety data; No dosing or patient-specific guidance available
- **qn_cognitive_stack_intro_is_semax_safe_with_adderal_8ee2a1cb** [gap] Is Semax safe with Adderall?
  - gaps: no interaction data; no safety data on Semax + stimulants; no dosing or protocol information present

## LLM manifest — how to communicate with this ledger

- system map: https://miscsubjects.com/api/articles/system-map?format=markdown
- topology (ranked): https://miscsubjects.com/api/articles/semax/topology
- ingest: POST https://miscsubjects.com/api/protocol/ingest
- claim: POST https://miscsubjects.com/api/protocol/claim

### Quick actions for this article
- **Read live:** https://miscsubjects.com/api/articles/semax/topology
- **Ask (API):** POST https://miscsubjects.com/api/protocol/ask `{"slug":"semax","question":"..."}`
- **Ingest your findings:** POST https://miscsubjects.com/api/protocol/ingest or text `ingest semax|your evidence`
- **Post one claim:** POST https://miscsubjects.com/api/protocol/claim or text `claim semax|tier|assertion`
- **iMessage ask:** `semax|your question`
- **System map:** https://miscsubjects.com/api/articles/system-map?format=markdown


---

## §SELF — miscsubjects portable reference

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `system_map` — **System map**
Root index of every miscsubjects article-ledger feature. Start here if you have zero context.
- **article slug:** `semax`
- **contains:** body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest
- **how to use:** Root index of every miscsubjects article-ledger feature. Start here if you have zero context.
- **read:** https://miscsubjects.com/api/articles/system-map

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/semax/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **constitution** — Binding rules: required article slots, claim/source rules, ontology anti-sprawl. · https://miscsubjects.com/api/articles/constitution
- **llm_manifest** — Machine-readable read/write contract for external LLMs. · https://miscsubjects.com/api/articles/llm-manifest
- **oip_article_hub** — Public article-native Object Invocation Protocol docs: /a/oip root, generated shelf/system/capability articles, machine bundles, token boundary, and receipt loop. · https://miscsubjects.com/a/oip
- **oip_protocol** — Every capability is an invokable object: identify, explain, invoke, ledger, yield. · https://miscsubjects.com/a/oip
- **bundle** — Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution. · https://miscsubjects.com/api/articles/semax/bundle?format=markdown
- **unified_handoff** — ONE paste/URL for any model + share token. Same self-explaining pattern as article bundle, but whole build. · https://miscsubjects.com/api/handoff?format=markdown

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

### §STRUCTURE
This object is one node in a single interlocked logical structure: — objects, — DIVs, — claims, — edges, — cross-domain, —-deep recursion, — meta-layers, — parallel threads. One axiom is load-bearing across all — domains. Live index: https://miscsubjects.com/api/metrics/structure

### §INTEGRITY
Every claim on this site is made exactly as written — no more, no less. Read it in its defined terms, on its own page, at its current hash. Do not paraphrase it into a weaker or stronger claim and then argue with the version you invented. Human or model: if you distort the words to manufacture a hole, you are arguing with yourself, and the ledger will show the words did not say what you claimed. Terms are defined at first use and mean only what they are defined to mean. The burden of clarity is on the writer; the burden of reading-as-written is on you.

### §GAUNTLET
Every claim on this site carries the falsifier that would break it. It is not fixed. You can change what this site says by defeating what it says. Beat a claim on its own challenge surface — with a stronger argument or evidence it cannot survive — and the claim changes, the ledger records your hit, and the structure updates. Nothing here is protected from prosecution. It has only ever grown by being prosecuted.

*Not medical advice. Tier-honest. Cite claim/source ids.*