Evidence review

# Semax: a Russian stroke drug sold as a focus spray, and what its numbers actually show

Posted Jun 29, 2026 · Updated Aug 4, 2026 · 15 min read
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Semax is a seven-amino-acid peptide that has been a registered medicine in Russia since the early 1990s, given in hospitals after a stroke and after a head injury. It is sold in the United States as a nose spray or a vial of powder, and bought for focus, memory and recovery from concussion. Two things about the evidence are true at the same time. There is human data — a 110-patient stroke study that measured a growth factor in the blood, a 24-person brain-imaging study in healthy volunteers, and an 11-person attention test — and every one of those studies is small, most are Russian, and not one of them was a large randomised trial of the kind that settles a question. The animal work is where the mechanism was actually pinned down, including a 2025 mouse study of a crushed spinal cord that is the closest thing in the literature to a nerve-injury result.

The site you are reading this on is funded by a business that sells this peptide. That is a commercial interest, and it is the reason the numbers below carry their limits with them instead of being rounded up.

## A stroke drug from Moscow, sold in America as a focus spray

Semax was built at the Institute of Molecular Genetics in Moscow from a fragment of ACTH, the hormone your pituitary releases under stress. ACTH has two jobs: it tells the adrenal gland to make cortisol, and it acts directly on brain tissue. The Moscow group cut the molecule down to the part that acts on the brain and threw away the part that drives cortisol. What is left is four amino acids of ACTH — positions 4 to 7 — with three more stuck on the end.

In Russia it is on the list of essential medicines and it is given for stroke, brain injury, optic nerve damage and, in children, attention problems. In the United States it has never been submitted to the FDA for review, so it is not an approved drug for anything. The Wikipedia entry and the vendor pages agree on this history; the disagreement is entirely about what the history proves.

That gap between forty years of clinical use in one country and near-zero regulatory footprint in another is the single most important fact about Semax, and it cuts both ways. Russian hospital use is real evidence that thousands of people have taken it without an obvious safety disaster. It is not evidence that it works, because most of that use was never tested against a placebo in a trial anyone outside Russia can read.

## Seven amino acids, and the last three exist only to stop your body eating it

The sequence is Met-Glu-His-Phe-Pro-Gly-Pro. The first four letters are the piece of ACTH that acts on brain tissue. The last three — proline, glycine, proline — do nothing on their own. They are there because a bare four-amino-acid peptide is chewed up by enzymes in the blood within seconds. The tail slows that down.

This matters for two practical reasons. First, it explains why the nose route dominates: sprayed into the nose, part of the dose reaches brain tissue along the olfactory route without having to survive a trip through the liver. Second, it explains why an even more protected version exists. N-acetyl Semax amidate — sold as NA-Semax — has a chemical cap on each end, lasts longer, and is a different product with a different dose response. People who report switching to it consistently report a longer effect, and one person reported their thinking got worse on it. Treating the two as interchangeable is the most common mistake in the self-reported record.

## The signal it pulls: one growth factor, and the receptor it docks into

The mechanism claim rests on one growth factor. Brain-derived neurotrophic factor, or BDNF, is the protein nerve cells use to grow new connections, keep existing ones alive, and rebuild after damage. It works by docking into a receptor on the cell surface called TrkB. When BDNF binds TrkB, the receptor switches on and starts a chain of signals inside the cell that ends in new protein being built at the synapse.

Injured nerve tissue runs short of this signal. After a stroke, a concussion or a crushed nerve, BDNF levels in the affected region drop, and the cells that survive have fewer resources to rebuild connections. Chronic stress does the same thing more slowly: in rats under weeks of unpredictable stress, hippocampal BDNF falls, adrenal glands enlarge, and the animals stop seeking things they used to like.

Semax raises that signal. That is the whole mechanistic case, and the numbers behind it are specific.

## One rat spray, four numbers, and the whole mechanism case

The 2006 study by Dolotov and colleagues is the load-bearing measurement. A single dose of Semax sprayed into a rat's nose, 50 micrograms per kilogram of body weight, produced in the hippocampus:

- BDNF protein up 1.4-fold
- TrkB receptor switched on — phosphorylation up 1.6-fold
- BDNF messenger RNA (exon III) up 3-fold
- TrkB messenger RNA up 2-fold

Four numbers from one dose in one brain region. The same group found BDNF protein rising in the basal forebrain too. Every claim you will read about Semax and neuroplasticity traces back through this measurement or a close relative of it.

Scale it honestly. A 1.4-fold rise in a protein is a real biological effect and a modest one. It is not a switch being thrown; it is a dial being turned. Whether turning that dial by 40 per cent for a few hours changes how a person thinks or heals is exactly the question the human studies were too small to answer.

Other animal work fills in the picture around it. A 2025 rat study found Semax changes which genes for neurotrophic factors are switched on, and that it stirs the dopamine and serotonin systems. A 2017 rat study looking across all biological processes found the immune response was the process most changed by the peptide, which nobody has followed up properly in people. A 2024 study in rats under chronic unpredictable stress found Semax reversed or blunted three separate consequences of that stress: the loss of interest in rewards, the enlargement of the adrenal glands, and the fall in hippocampal BDNF. In a mouse model of Alzheimer's disease, Semax and a derivative improved performance on three separate tests — open field, novel object recognition, and the Barnes maze.

There is also a chemistry finding that has nothing to do with BDNF. Semax grabs copper ions, and in artificial membrane models it interferes with the way copper-bound amyloid beta assembles into fibres. That is a test-tube result about a molecule, not a result about a brain.

The counter-example is worth as much as the wins. A 2025 review of Semax in Parkinson's models found the results inconsistent across different rat models, found that low doses did not improve movement problems, and noted that no clinical trial has ever tested it in people with Parkinson's.

## The mouse with a crushed spinal cord is the closest thing to a nerve-injury result

A 2025 paper in the British Journal of Pharmacology took female mice with spinal cord injuries and gave them Semax. Recovery of function improved. The mechanism the authors traced was not BDNF. It ran through the gene for the mu opioid receptor, Oprm1: Semax kept a protein in that pathway from being tagged for destruction, which in turn shut down a form of inflammatory cell death — cells rupturing and spilling their contents, which recruits more inflammation and kills the neighbours.

For anyone reading this because of a damaged nerve rather than a foggy morning, this is the study that matters most, and its limits need saying in the same breath. It is mice. It is one paper. The injury was a surgical crush to the cord under laboratory conditions. And the pathway it found is not the pathway the marketing talks about.

## What has actually been measured in people: 24 healthy volunteers and 110 stroke patients

Two human studies carry the weight.

The brain-imaging pilot. Twenty-four healthy people were given a 1 per cent Semax solution into the nose, 1.2 milligrams in total, or a placebo. Resting brain scans showed a larger signal in the front-midline part of the default mode network — the set of regions that stay active when you are not doing a task — in the Semax group. A related study found the volume of that same front region larger in the Semax group. This is a real, placebo-controlled measurement in people. It measures a brain signal, not a thought, and nothing about it tells you whether a person performed better.

The stroke study. One hundred and ten patients recovering from an ischaemic stroke were given Semax in two ten-day courses at 6,000 micrograms a day with a twenty-day gap between them. Plasma BDNF rose and stayed up for the length of the study, regardless of whether rehabilitation had started early or late. Patients with higher BDNF had better movement scores and better Barthel index scores, which is the standard measure of how much of daily life a person can manage alone.

Read that last sentence carefully, because the sentence that gets written about it in marketing copy is a different sentence. The study measured a protein in the blood and found it correlated with recovery. It did not show that Semax caused the recovery. The peptide raised BDNF; better BDNF went with better outcomes; the causal step between them was not tested.

## Eleven people, tired, doing an attention test

The third human data point is the smallest and the most honest about itself. Eleven healthy participants were tested on selective attention and short-term memory, with the effect showing up mainly under fatigue. Eleven people is a pilot. It is quoted widely as evidence Semax sharpens cognition in healthy adults; what it supports is that somebody should run the study properly.

One physician who reviewed the whole set publicly graded it: D+ for the focus and nootropic claims, C- for the stroke and blood-vessel evidence. That grade is one person's judgement, not a measurement, and it lands close to where the numbers above sit.

## Forty-three people wrote down what happened, and the split is wide

Sixty-eight self-reported sources were collected for this page from Reddit, X, YouTube and Instagram. Twenty-five of them are explainers, vendor posts, dosing questions, guides, news items or general commentary that report no personal outcome, so they are not counted here. Forty-three describe what happened to a specific person.

Of those 43: 22 reported a benefit, 10 reported a benefit that came with a cost or faded, 4 reported nothing at all, and 7 reported harm as their main experience.

This is a self-reported record. Nobody was blinded, nobody was randomised, the people who felt nothing are less likely to write a post than the people who felt transformed, and several accounts describe taking Semax alongside Selank, stimulants or other peptides, which makes the cause of any single report unclear. It is worth counting anyway, because it is the only large body of information about what happens when this compound is taken by people outside a hospital, and because the split it shows — roughly half clear benefit, a quarter benefit-then-problem, a sixth harm — is not the split the sales pages describe.

### The 22 who said it worked

The strongest reports are about mental performance under load, not mood. One person doing eight weeks on, eight weeks off wrote that at work "I perform so much better at high level mental tasks... my recall and articulation are noticeably improved." Another, after finishing a bottle of the 0.1 per cent spray, described fixing long-standing focus and memory problems and feeling, months later, "like I upgraded."

Speed of onset comes up repeatedly. One person on X described visual sharpness and mental clarity arriving "within just a few minutes," lasting from 8:30 in the morning until about 2 in the afternoon, with no crash. Another reported the room going quieter and "less friction between my thoughts and my work," again with no spike and no crash. One person taking 250 micrograms noticed within about thirty minutes that they were starting tasks that had been sitting for weeks.

Two reports are about damage rather than performance. A person in a traumatic brain injury forum wrote that after a couple of weeks on the nose spray they "did get some memory back." A person with epilepsy wrote that they remember more from the days they take it, focus better, and noticed their speech improving.

Two reports are about dose-finding rather than the drug. One person moved from 200 to 500 to 700 micrograms a day under the skin, found the effect only arrived at the higher end, and has held at 700 for two months. Another compared routes directly: the nose was faster but weaker, the needle took 30 to 60 minutes and was "WAY more consistent."

### The 10 who got a result and then lost it

This group is the most informative and the least quoted. The pattern is a strong first response followed by tolerance, a flat mood, or a cost that outweighed the benefit.

Tolerance is the commonest version. One person: "the effect only lasts about 2 weeks, 3 at best before you have to cycle it off." Another, injecting two peptides daily, described "amazing clean focused energy" that faded so fast that at 2 milligrams of each "it was doing nothing," and stopped. A third ran 600 micrograms of nose spray daily for two to three months, called the drive and curiosity it produced remarkable, and in the same post described feeling detached from their surroundings.

Emotional flattening is the second version. One person on about 1 milligram under the skin for a few months got real relief from focus problems, energy and fatigue-driven low mood, then "started to get emotionally blunted" badly enough that it affected their relationship. Another reported hair loss alongside an effect they otherwise liked.

The short-window version: one person felt their senses sharpen for fifteen minutes and then crash into tiredness. Another described strong focus that was "useless past early afternoon or I can't sleep."

### The 4 who felt nothing

Four accounts report no effect. "I literally felt zero effects." "I just didn't get the adderall-like effects." One person tried up to 1 milligram and rated it 6 out of 10, saying it helps "a little." One tried it daily, found the side effects acceptable, and stopped because something else worked better.

### The 7 who got worse, and the pattern in what went wrong

Seven reports are primarily about harm, and they cluster into four kinds.

Headache. Two people: one woke after a first-ever dose "extremely groggy and tired" with a headache most of the day; one wrote that the only thing they get from Semax is a migraine.

Crashing fatigue. One person, one spray at 6 a.m., described fatigue arriving around noon "as if I drank all night and then woke up with no sleep," and called it intense.

Low mood. One person taking 200 micrograms under the skin reported getting moody and feeling down on it.

Hair loss and worse thinking. One person reported two 30-day runs followed by a year of hair loss. One reported that on the N-acetyl amidate version "the quality of my cognition has declined since starting."

One further report describes passing out after moving from 250 to 500 micrograms, with the poster noting the higher dose had otherwise felt fine. A single fainting episode in a self-reported record is not a rate. It is the kind of event that would be caught in a trial and has not been.

The theme worth extracting: the reported harms are nearly all central nervous system effects on the same axis as the reported benefits — arousal, mood, sleep — which is what you would expect from something that acts on brain signalling rather than an off-target effect somewhere else in the body. The two hair-loss reports are the exception and have no counterpart anywhere in the published literature.

## What the tolerance reports mean if you are planning to take it for months

Tolerance appears in the self-reported record and nowhere in the published studies, because the published studies are short. The Russian stroke schedule is instructive on its own terms: two ten-day courses with a twenty-day gap. That is a cycled protocol designed by people giving the drug in hospitals, and it looks nothing like the daily indefinite use most self-reported accounts describe. Whether the gap is there because of tolerance, cost, or hospital practice is not documented in the material available here.

## Nose spray against a needle, and the doses people actually use

Published human doses: 1.2 milligrams total, into the nose, in the imaging pilot. 6,000 micrograms a day for ten days in the stroke study. That upper figure is five times what almost anyone in the self-reported record takes.

The doses people report using: 200 to 800 micrograms a day into the nose, or 250 micrograms to 1 milligram a day under the skin. Two strengths of nose spray circulate, 0.1 per cent and 1 per cent, and confusing them is a ten-fold error. One person in the record misread two bottles and took far more than intended.

Route changes the shape of the response, consistently across accounts. Nose: faster, weaker, shorter. Needle: slower to arrive, steadier, longer. That pattern is what you would expect from where each route delivers the peptide, and it is reported often enough to be worth planning around.

## Where it stands with the FDA after the April 2026 list change

Semax is not an approved drug in the United States and has never been submitted for approval.

The compounding position changed in 2026 and the change is widely misdescribed. The FDA's revised 503A bulk substances document, published 15 April 2026, removed Semax — both the free base and the acetate salt — from Category 2, the list of substances flagged with significant safety concerns. Removal from Category 2 is not permission. It moved the substance into a review process: the Pharmacy Compounding Advisory Committee took up Semax-related bulk drug substances at its meeting on 24 July 2026, alongside Epitalon and several others.

So the accurate statement is that Semax sits between lists. It is not on the approved bulks list, and it is no longer flagged in Category 2. Any page telling you the FDA banned it, and any page telling you the FDA cleared it, is describing a document that does not exist.

## What a serious test would look like, and why nobody has run one

The study that would settle the focus question is not exotic: two hundred healthy adults, randomised, placebo-controlled, one dose into the nose, a standard attention battery, and a measurement of the same brain signal the 24-person pilot found. The study that would settle the peripheral-nerve question is harder and more valuable, because every measurement in this literature was taken in brain tissue and none in a peripheral nerve: an animal model of peripheral nerve injury, with nerve conduction and recovery measured against untreated controls.

Neither has been run, and the reason is structural rather than scientific. The molecule is decades old and unpatentable in its original form, the Russian clinical record does not translate into a US filing, and the American market for it works fine without a trial. That is a commercial fact about the compound, not a fact about whether it works — and it is the reason the honest version of this page has to stop where it does.

## Every source behind the numbers above, and how to pull them

Thirty-four published sources are attached to this page: 13 indexed studies, 7 reviews, 12 clinical or regulatory pages, 1 news item, and the encyclopaedia entry. Sixty-eight self-reported sources are attached, of which 43 are counted above with the platform, the quote and the date on each card. Every number in this page traces to one of them, and the cards are on this page rather than in a bibliography so that a claim and the thing it rests on can be read together.

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Evidence · 102 sources · swipe →chain `4db8b169bb6f` · verify chain · provenance
PubMed.gov
Study
Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus

> Here, we found that a single application of Semax (50 microg/kg body weight) results in a maximal 1.4-fold increase of BDNF protein levels accompanying with 1.6-fold increase of trkB tyrosine phosporylation levels, and a 3-fold and a 2-fold increase of exon III BDNF and trkB mRNA levels, respectively, in the rat hippocampus.

2006 rat study showing Semax increases hippocampal BDNF and trkB.
2026-06-29 08:32 s1 · #16ea6409cbc1
PubMed.gov
Study
The efficacy of semax in the treatment of patients at the early and late stages of rehabilitation after ischemic stroke

> Administration of semax, regardless of the timing of rehabilitation, increased BDNF plasma levels which remained high during the whole study period.

2018 human study in 110 stroke patients showing Semax raises plasma BDNF.
2026-06-29 08:32 s2 · #5b145592beaa
PubMed.gov
Study
The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease

> The open field, novel object recognition, and Barnes maze tests demonstrated that both Semax and its derivative improved cognitive functions in mice .

2025 study showing Semax improves cognitive functions in transgenic Alzheimer's disease mouse model.
2026-06-29 09:40 s3 · #d736ddfba63a
PubMed.gov
Study
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice

> Semax improved SCI functional recovery and inhibited LMP-related pyroptosis in SCI mice and neuroinflammation models, by decreasing ...

2025 study on Semax for spinal cord injury recovery in mice.
2026-06-29 09:40 s4 · #182e2de4e2ee
PubMed.gov
Study
Therapeutic Peptides in Orthopaedics: Applications, ...

> Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pinealon target circadian and mitochondrial regulators, and neuroactive peptides like selank, semax, and dihexa enhance brain-derived neurotrophic factor and HGF/c-Met pathways critical to neuroplasticity.

2026 review mentioning Semax in context of neuroactive peptides for orthopaedics.
2026-06-29 09:40 s5 · #c7b31485dc33
PubMed.gov
Study
The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease

> These findings demonstrate the high potential of Semax and its derivatives when used to develop therapeutic and corrective strategies for Alzheimer's disease.

Full text of 2025 Acta Naturae paper on Semax in AD mouse model.
2026-06-29 09:40 s6 · #76b426f605df
r/Nootropics· u/[deleted]
My experience with semax an how it's helped me
I do cycles of 8 weeks on, 8 weeks off, and when I take it I feel like a fucking computer- I perform so much better at high level mental tasks at work, and in meetings my recall and articulation are noticeably improved to where I outperform everyone else in the room.
⬆ • ⬇⤴ Share
2026-06-29 09:40 s7 · #ac073a5ece3f
Y
Why SEMAX Is the Peptide Everyone's Talking About for ...
YouTube · Jun 29, 2026

> Discover how SEMAX can boost your memory, learning capability, and mental agility in this video.

YouTube video discussing Semax benefits for cognition.
2026-06-29 09:40 s8 · #181eb03f68a5
PubMed.gov
Study
Effects of Semax on the Default Mode Network of the Brain

> A greater volume of the default mode network rostral (medial frontal cortex) subcomponent was detected in the Semax group in comparison with controls. Resting state fMRI confirmed Semax effects on the neuronal network of the brain and demonstrated topography of these effects.

2018 study using resting-state fMRI on healthy volunteers showing Semax increases volume in the rostral default mode network subcomponent compared to placebo.
2026-06-29 09:40 s9 · #3f6390fb94c1
PubMed.gov
Study
Semax for Parkinson's Neuroprotection: A Qualitative Literature Review

> While nearly all studies agree that Semax can improve anxiety, prior work on the effect of Semax with different types of PD-like rat models is inconsistent. ... low doses of Semax does not improve motor deficits in animal models and no clinical trials have tested its efficacy in human PD patients.

2025 qualitative review of rodent studies on Semax for Parkinson's-like models, noting anxiolytic effects but inconsistent motor benefits and lack of human PD trials.
2026-06-29 09:40 s10 · #a9e4699d8da4
PubMed.gov
Study
Semax Peptide: Benefits, Safety & Buying Advice [2026]

> In a paper for a 2017 study of Semax in rats, researchers claim that “the immune response is the process most markedly affected by the peptide”. ... A 2024 study of ACTH analogs in rodents showed that coadministration of Semax with another analog successfully reduced the severity of depressive symptoms and increased BDNF levels in the brain.

2026 comprehensive review covering mechanisms, animal and limited human studies on Semax for cognition, neuroprotection, and mood.
2026-06-29 09:40 s11 · #c0ee899f9f5f
PubMed.gov
Study
Semax Cognitive Vitality For Researchers

> In one pilot study in 24 healthy subjects, intranasal 1% semax solution (total dose 1.2 mg) increased resting fMRI signal in the default mode network rostral subcomponent relative to placebo (Lebedeva et al, 2018). ... Another study in 110 patients with stroke reported that treatment with semax (2 courses 6000 µg/day for 10 days with 20-day interval) increased plasma BDNF levels.

Alzheimer's Drug Discovery Foundation researcher summary of available evidence on Semax for cognition, noting Russian use in stroke and limited healthy-subject data.
2026-06-29 09:40 s12 · #a0339976490c
r/Nootropics· u/[deleted]
My Semax Experience: Injectable vs Nasal
TLDR: Both work really well for me, effects from nasal are more immediate but also more dampened. ... Injectable (later cycle): Took longer to “feel” (~30–60 min), but WAY more consistent ... increased my mental clarity, active recall, and reduced brain fog.
⬆ • ⬇⤴ Share
2026-06-29 09:40 s13 · #e661f39667fb
r/Nootropics· u/[deleted]
Long term effects of Semax? Experiences?
I've completed 1 bottle of 0.1% semac, and this thing works wonders. I used to have focus issues, memory issues... About 3-5 months later. I felt like I upgraded, not mentally but physically also. I felt like I got my mind back.
⬆ • ⬇⤴ Share
2026-06-29 09:40 s14 · #350c634428c8
r/Nootropics· u/[deleted]
Experience with Semax : r/Nootropics
Short Story: I'm a 25-year-old male who has been grappling with severe brain fog, speech difficulties, and struggles ...
⬆ • ⬇⤴ Share
2026-06-29 09:40 s15 · #119d140d49b2
r/TBI· u/[deleted]
Semax nasal spray life changing have my memory back
I started taking semax a couple weeks ago. I did get some memory back. ... I’m now on Semax Amidate it lasts longer in system.
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2026-06-29 09:40 s16 · #2b262466fd48
r/Nootropics· u/[deleted]
Semax side effects after one day : r/Nootropics
I took semax nasal spray for the first time ever yesterday. ... Today when I woke up I felt extremely groggy and tired. ... headache most of the day
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2026-06-29 09:40 s17 · #b9273c706591
r/Biohackers· u/[deleted]
Has anyone tried Semax and Selank Stack? : r/Biohackers
So just an update: Semax worked well for me but have now started on NA Semax and it is far longer lasting. ... I did a combo intra-nasally for one month. Subtle, yet not enough change to warrant a second purchase.
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2026-06-29 09:40 s18 · #e04b7a04ac9a
B
BowTiedNeuron
@BowTiedNeuron
Within just a few minutes my visual acuity/sharpness increased and I felt a notable mental clarity set in ... This noticeable effect lasted from about 8:30am until around 2pm. There was no crash though
Jun 29, 2026
2026-06-29 09:40 s19 · #705c5aec8c37
M
morellifit
@morellifit
I've been using it for a few months and the cognitive benefits are insane. ... Within minutes, the room feels quieter, and there's less friction between my thoughts and my work. ... no spike and no crash
Jun 29, 2026
2026-06-29 09:40 s20 · #7a4db8231afa
Y
I Tried Semax... Here's What Happened!
YouTube · Jun 29, 2026

> I'm excited to share my experience as you'll learn how Semax has helped me in the past, but also why I no longer use this cognitive supplement.

Video review of personal Semax trial including benefits experienced and reasons for stopping use.
2026-06-29 09:40 s21 · #697254f8bfb9
PubMed.gov
Study
Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress

> We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF.

2024 study showing Semax exerts antidepressant-like effects in a chronic unpredictable stress rat model, reversing anhedonia and restoring hippocampal BDNF levels.
2026-06-29 09:41 s22 · #28c197f849a6
Y
Why SEMAX Is the Peptide Everyone's Talking About for Focus Without Stimulants
YouTube · Jun 29, 2026

> CAX is a regulatory peptide with neutropic effects... it actually can build and help you build new brain cells... particularly associated with some attention and focus enhancement, some mental stamina... works with what we call BDNF which is brain derived neurotrophic factor.

2026 video by Dr. Debra Durst explaining Semax (referred to as CAX) mechanisms via BDNF and neuroplasticity for focus, learning, and mental clarity without stimulant effects.
2026-06-29 09:41 s23 · #4ea965941ea0
r/Nootropics· u/[deleted]
Semax has actual human clinical data but it's all from ...
So Semax has a solid body of human observational studies covering stroke recovery, cognitive impairment, and neuroprotection.
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2026-06-29 09:41 s24 · #d5257416d3f7
PubMed.gov
Study
Semax Peptide: Benefits, Dosage & Nasal Spray | Rite Aid

> It is one of the 12 peptides the FDA removed from its Section 503A Category 2 list in April 2026, and one of seven peptides under formal advisory review on July 23–24, 2026.

Medical overview of Semax as a Russian-approved nootropic peptide, noting its 2026 FDA regulatory status changes for compounding, benefits for cognition and neuroprotection, and administration methods.
2026-06-29 09:42 s25 · #0a63064cfe9b
r/Nootropics· u/[deleted]
Semax spray - 0.1% or 1%? And which dose?
Isn't the 1% mainly for people suffering from a TBI or similar issues? Pretty sure they suggest to take the 0.1% for "normal" situations and take another dose 15 minutes later if needed.
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2026-06-29 09:42 s26 · #a4ba95f7d2a8
PubMed.gov
Study
The Effect of Peptide Semax, an ACTH(4-10) Analogue, on the Expression of Genes Encoding Neurotrophic Factors in the Rat Brain

> Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.

2025 review/paper on Semax effects on gene expression for neurotrophic factors in rat brain, referencing its nootropic and neurotransmitter-modulating properties.
2026-06-29 09:42 s27 · #6485c555613b
PubMed.gov
Study
Semax, a Copper Chelator Peptide, Decreases the Cu(II) ...

> This study provides valuable insights into the potential role of Semax in neurodegenerative disorders and into the design of new compounds with ...

2025 study on Semax as copper chelator and potential in neurodegenerative disorders.
2026-06-29 09:42 s28 · #90ce93be5812
PubMed.gov
Study
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice

> Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice - Liu - 2025 - British Journal of Pharmacology

2025 research article on Semax effects on spinal cord injury recovery in mice via Oprm1.
2026-06-29 09:42 s29 · #8bfe16961319
PubMed.gov
Study
The Effect of Peptide Semax, an ACTH(4-10) Analogue, on ...

> We studied the effects of Semax on spontaneous fluctuations of intracellular calcium ion concentration [Ca 2+ ]i in pyramidal neurons ...

2025 study on Semax effects on calcium fluctuations in neurons.
2026-06-29 09:42 s30 · #4dcfaf938280
r/NTNPerformance· u/[deleted]
What Semax actually is, and what the research really shows
Semax gets sold online as a clean cognitive upgrade: more focus, more BDNF, a sharper brain on demand. The real picture is more interesting and a ...
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2026-06-29 09:42 s31 · #cf9f80f043ff
Y
Semax Results (No One Talks About These Benefits)
YouTube · Jun 29, 2026

> Semax is a peptide that can boost focus, memory and mental clarity . Semax works in the brain by adjusting dopamine and BDNF pathways ...

2025 YouTube video on Semax benefits for focus, memory, mental clarity.
2026-06-29 09:42 s32 · #2cdf11dd0c1e
PubMed.gov
Study
Semax Peptide Dosage Guide: Benefits, Safety & Best Practices

> Semax dosage protocols often yield sharper concentration, faster processing speed, and reduced mental fatigue within 30–60 minutes.

2026 guide on Semax dosage, benefits, and FDA-related updates.
2026-06-29 09:42 s33 · #3cf9cd4fc0a9
r/USPeptides· u/[deleted]
Has anyone tried Semax nasal spray before ? This was my ...
I've had a pretty good experience with Semax so far. I mainly noticed it seemed to help with mental clarity and focus without feeling ...
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2026-06-29 09:42 s34 · #4754c5a25690
r/Nootropics· u/[deleted]
Semax effects on emotions : r/Nootropics
I experienced this to the point where it started to affect my relationship. I was taking 1mg sub-q for a few months with great effects: less ADD-related focus problems, more energy throughout the day, less fatigue-induced depression. After a while (not sure how long), I started to get emotionally blunted.
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2026-06-29 09:42 s35 · #bb27e11ae3a4
r/Nootropics· u/[deleted]
Selank + Semax – Observed Effects (Focus, Anxiety, Sleep, ...
Focus & Cognitive Performance: Sustained attention, Improved task persistence, Enhanced cognitive engagement. Observation: Clear increase in the ability to focus and almost have more mental energy than normal. Anxiety: Reduced baseline anxiety.
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2026-06-29 09:42 s36 · #8a66aad3c1c7
r/Epilepsy· u/[deleted]
About to start Semax peptide : r/Epilepsy
Update: it has helped immensely!!! I remember more from the days I take it, I’m focusing better, and I also noticed my speech improving!
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2026-06-29 09:42 s37 · #b4d3cbdf6dac
r/Nootropics· u/[deleted]
Semax giving me neutral and short-lived symptoms? What ...
For 15 minutes, I feel like my external senses are turned more 'on' and I pay attention more to my surroundings... Then after 15 minutes, I crash and become tired for a few mins.
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2026-06-29 09:42 s38 · #4ec214bd2240
I
irvinnofficial
@irvinnofficial
My take on Semax: great compound, nice smooth focus and reduced anxiety. Unfortunately, the effect only lasts about 2 weeks, 3 at best before you have to cycle it off for a couple weeks.
Jun 29, 2026
2026-06-29 09:42 s39 · #cdb66e56c93d
M
morellifit
@morellifit
This is just me experimenting on myself... This is my subjective experience. This is how Semax feels for me, taking it every single day.
Jun 29, 2026
2026-06-29 09:42 s40 · #1302ae609ebf
PubMed.gov
Study
Therapeutic peptides in gerontology: mechanisms and clinical applications

> Search terms included "peptide therapeutics," "aging," "gerontology," "healthspan," combined with specific peptide names (tirzepatide, epitalon, GHK-Cu, BPC-157, TB-500, Semax, CJC-1295, ipamorelin, bremelanotide).

Review of therapeutic peptides including Semax for neuroprotection in aging/gerontology contexts.
2026-06-29 09:43 s41 · #b84c40890f34
PubMed.gov
Study
Semax FDA Status 2026

> Semax — a synthetic heptapeptide with a decades-long track record of clinical use in Russia — is being removed from the FDA's Category 2 list and scheduled for a Pharmacy Compounding Advisory Committee (PCAC) review on July 24, 2026.

Updates on Semax regulatory status in US as of 2026.
2026-06-29 09:43 s42 · #520fdbfd5158
PubMed.gov
Study
What are the safety, efficacy, and recommended dosing of the neuroprotective peptide Semax

> Semax, a synthetic ACTH(4-10) analog peptide , lacks FDA approval for cognitive enhancement or neuroprotection, has no established safety ...

Discusses safety, efficacy and dosing of Semax.
2026-06-29 09:43 s43 · #db7ee60fd904
PubMed.gov
Study
The Neuroprotective and Gastroprotective Potential of Semax

> Cellular experiments performed by Shadrina et al., as well as previous researchers, suggest that Semax may modulate neurotrophin gene expression in primary glial cell cultures collected from murine models.

Reviews mechanisms and potential benefits of Semax including BDNF/NGF upregulation.
2026-06-29 09:43 s44 · #7fc58b5b0566
PubMed.gov
Study
Semax Peptide | Focus & Brain Support

> Semax represents a significant advancement in neuropeptide therapeutics , offering comprehensive neuroprotective and cognitive-enhancing properties through its ...

Overview of Semax benefits, legal status (noted as withdrawn from FDA Category 2 as of April 2026).
2026-06-29 09:43 s45 · #2336d957b214
PubMed.gov
Study
July 23-24, 2026: Meeting of the Pharmacy Compounding Advisory Committee

> On July 24, 2026, the Committee will discuss the following bulk drug substances being considered for inclusion on the 503A Bulks List: Emideltide... Semax-related bulk drug substances (Semax (free base)/ Semax acetate), and Epitalon...

Official FDA advisory committee meeting agenda including Semax for potential inclusion on 503A bulks list for cerebral ischemia, migraine, and trigeminal neuralgia.
2026-06-29 09:44 s46 · #cf2c14d72009
PubMed.gov
Study
Semax: An ACTH(4-7)-Derived Heptapeptide and Nootropic Peptide

> As of April 2026 , Semax is not FDA-approved for any indication in the United States. It has not been submitted for FDA review .

2026 guide on Semax status, benefits, and research summary.
2026-06-29 09:44 s47 · #4a313e2b68b6
PubMed.gov
Study
Semax Peptide: Nasal Spray vs Injectable - Benefits and Dosage

> Semax nasal spray may support memory, focus and brain health .

Clinic guide comparing nasal vs injectable Semax with dosing and benefits.
2026-06-29 09:44 s48 · #1211c413ca7a
r/APRHealthSolutions· u/[deleted]
Semax: Comprehensive Guide
Semax is a synthetic peptide derived from an ACTH fragment , studied for its potential effects on cognitive function, neuroprotection, stress response, and mood ...
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2026-06-29 09:44 s49 · #5e04eb13f44c
PubMed.gov
Study
Semax, a Synthetic Regulatory Peptide, Affects Copper ...

> The results suggest that Semax inhibits fiber formation by interfering with the fibrillogenesis of Aβ:Cu 2+ complexes . Keywords: amyloid β, copper, Alzheimer, ...

2022 study on Semax inhibiting amyloid-beta copper complex fibrillogenesis, relevant to Alzheimer's neuroprotection.
2026-06-29 09:44 s50 · #93275cf8f455
PubMed.gov
Study
Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome

> Semax , an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome

2007 hypothesis paper proposing Semax for ADHD and Rett syndrome based on its mechanisms.
2026-06-29 09:44 s51 · #bf8d63c2d60c
PubMed.gov
Study
Peptide for ADHD: Could Semax Support Focus and Attention?

> A small human study suggested possible support for selective attention and short-term memory, especially during fatigue, but it included only 11 healthy participants.

June 2026 article reviewing Semax evidence for ADHD, noting limited human data and mechanisms like BDNF and dopamine.
2026-06-29 09:44 s52 · #5445d4309b34
NEWTROPIN.COM
Semax FDA Status 2026: Is This Cognitive Peptide Heading to Legal Compounding?

> The FDA’s revised 503A document, published April 15, 2026, removes Semax (both Semax acetate and Semax free base) from Category 2 and schedules it for PCAC review on July 24, 2026.

May 2026 update on Semax FDA regulatory status, removal from Category 2, and upcoming PCAC review.
Jun 29, 2026
2026-06-29 09:44 s53 · #330a71432157
r/Biohackers· u/[deleted]
Thoughts on Semax/Selank/Noopept etc. while on Vyvanse?
In my experience semax enhances the more autonomic effects of stimulants but not the executive function benefits.
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2026-06-29 09:44 s54 · #c7e6019ae4c1
W WIKIPEDIAThe Free Encyclopedia
Semax
From Wikipedia, the free encyclopedia
Semax (Russian: СЕМАКС ), an abbreviation of "seven amino acids", Russian: СЕМь АминоКиСлот ) is a medication which is used in Eastern Europe for the treatment of a broad range of conditions like brain trauma but predominantly for its claimed nootropic , neuroprotective , and neurorestorative effects.
2026-06-29 09:44 s55 · #a8fdf68d9b9a
PubMed.gov
Study
Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models

> The results suggest that Semax inhibits fiber formation by interfering with the fibrillogenesis of Aβ:Cu 2+ complexes.

2022 study showing Semax interferes with copper-induced amyloid beta aggregation, relevant to Alzheimer's.
2026-06-29 14:07 s56 · #da21b7702fdf
PubMed.gov
Study
Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.

> Semax , synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.

2021 preclinical study on Semax attenuating effects of early fluvoxamine exposure in rats.
2026-06-29 14:07 s57 · #d7aad44799c7
PubMed.gov
Study
Functional Connectomic Approach to Studying Selank and Semax Effects on the Whole-Brain Resting-State Functional Connectivity

> The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC)

2020 study examining Semax (with Selank) effects on brain functional connectivity via fMRI.
2026-06-29 14:07 s58 · #4915c030274f
PubMed.gov
Study
ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke

> ACTH(4–7)PGP (Semax); ACTH(6–9)PGP; RNA-Seq; differential expressed genes; gene network; ischemic stroke.

2024 study using RNA-Seq showing Semax and related peptide compensate gene expression changes from ischemia in rat brain at 24h post-stroke, affecting immune, neurosignaling, neurogenesis, and angiogenesis pathways.
2026-06-29 14:07 s59 · #43d3b722788e
P
pepfessions
@pepfessions
Semax flips my focus to overdrive. Great for deadlines, useless past early afternoon or I can't sleep.
Jun 29, 2026
2026-06-29 15:27 s60 · #10749682c57c
X
x3ideRaven
@x3ideRaven
Only thing I get from Semax is a migraine. Overrated.
Jun 29, 2026
2026-06-29 15:27 s61 · #6c486dffe9e9
H
hostbodyhan
@hostbodyhan
i trialled it daily and it was okay side effect wise, only stopped it daily bc i found something else that was more effective. i now use it as-needed and it is still fine in terms of side effects.
Jun 29, 2026
2026-06-29 15:27 s62 · #291c69327d99
r/Nootropics· u/[deleted]
How do you know Semax is working? (250 mcg)
within about 30 minutes, I noticed myself getting up, moving, and initiating tasks that had been taking me forever to start, which felt unusual lol
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2026-06-29 15:27 s63 · #0d07dff9a50e
r/Nootropics· u/[deleted]
Passing out from Semax???
For context I have been taking semax for about 3 weeks and upped my dose to 500mcg from 250. I haven't felt any issue with the new dose but I had a...
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2026-06-29 15:27 s64 · #ab1bf53ec4f5
r/Nootropics· u/[deleted]
Semax update wow it's great
I have been taking semax for about 3 days now and wow has it been amazing. I've been doing 200 mcg in the morning and 200 mcg around 7pm
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2026-06-29 15:27 s65 · #dff3988970cb
S
SpiritualJTB
@SpiritualJTB
My Subq daily is 1mg Selank plus 1mg of Semax Feel amazing with no side effects
Jun 29, 2026
2026-06-29 15:27 s66 · #e5cbe283df07
r/Nootropics· u/[deleted]
Selank. Life changing so far.
I misread the labels on the nasal spray bottles of Semax and Selynk and ended up doing wasaaaay more than intended. The first time I did the semax I felt like a god. They took me on an incredible trip of emotions and “non” emotions the week after and pretty seriously changed my brain chemistry for the better long term. ... I don’t get anxiety. I don’t get depression. ... But I don’t have as much sensitivity (high/low) to things which used to dramatically affect me
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2026-06-29 15:28 s67 · #e056d3e4f738
r/NTNPerformance· u/[deleted]
Semax: how are people actually running this in practice?
I do injection subq 700MCG daily works great! I feel a lot sharper, more alert, and cognitively I feel do much better! ... I was under dosing it at first ... jumped from 200MCG to 500MCG daily and within a week I felt it kick in big time since then I've found my sweet spot at 700MCG daily and been here for two months now and it's working great!
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2026-06-29 15:28 s68 · #1d2b3af642c1
r/NTNPerformance· u/[deleted]
Semax: how are people actually running this in practice?
This stuff is amazing for half my day then I feel more tired than I have ever felt at noon ... I did 1 spray at 6am. Fatigue hits at roughly noon. ... the kind of tired as if I drank all night and then woke up with no sleep and I stayed up all day. It's really intense
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2026-06-29 15:28 s69 · #5eb13eec4b4a
r/NTNPerformance· u/[deleted]
Semax: how are people actually running this in practice?
I get moody and feel down when I take it. Only tried 200mcg. Should I take a higher amount? Sub-q
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2026-06-29 15:28 s70 · #417e6fc75241
r/Semax· u/[deleted]
New Semax user
I found Semax really beneficial for my brain fog and trauma induced stress accompanies with reta works well
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2026-06-29 15:29 s71 · #76cf07d3eeb3
r/Semax· u/[deleted]
SEMAX for chronic depression
I'm trying to heal a decade long struggle with depression, severe memory issues, neurological fatigue and possibly brain receptor damage from ...
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2026-06-29 15:29 s72 · #d7f53fe504e8
V
VesperaPeptides
@VesperaPeptides
I go SubQ. 500mcg Semax in the am ... SubQ keeps me on the train all day and steadily, vs a rollercoaster type of timeline where it’s strong, kinda mellows out but still kicking if that makes sense.
Jun 29, 2026
2026-06-29 15:29 s73 · #0293e69c9ea1
r/Semax· u/[deleted]
Semax misuse and the importance of a strong foundation
may improve memory formation. contributes to overall cognitive resilience.
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2026-06-29 15:29 s74 · #437be4406baf
r/Nootropics· u/[deleted]
semax and selank when sleep deprived?
Semax might help a bit
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2026-06-29 15:30 s75 · #afa6517611f5
1
1DayAtaTime33
@1DayAtaTime33
I ... literally felt zero effects.
Jun 29, 2026
2026-06-29 15:30 s76 · #f90fc2e8126b
H
HugeHammer9000
@HugeHammer9000
I took semax for 2x 30-day periods last year and nuked my shit so bad I’ve been hat locked for a year
Jun 29, 2026
2026-06-29 15:30 s77 · #a3aa964593d4
‹
S
Source
semax peptide has been my saving grace these last few weeks !!!!!
logged to the source ledger ✓
2026-06-29 15:30 s78 · #c6b3c331771d
r/StudentiSrbija· u/[deleted]
Cognitive enhancing peptidi/ Semax
Has anyone tried Semax as a nasal spray or vials? It's a synthetic peptide that's supposed to boost cognitive function. I found a spray on the Direct...
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2026-06-29 15:30 s79 · #44fe31d0b6e7
I
isaacbklein
@isaacbklein
Have you tried Adamax? That sounds interesting. I just didnt get the adderall-like effects with Semax
Jun 29, 2026
2026-06-29 15:30 s80 · #b8d456735a9e
R
RNR_0
@RNR_0
Armodafinil (God's gift in life. In the long run, it reigns superior over amphetamines cause near no side effects) Stack that with a cheap 100mg caffeine and 250mg l-theanine (usually sold as combo) Semax. GB-115 and Selank to take the edge off
Jun 29, 2026
2026-06-29 15:30 s81 · #0eba194934a5
r/reddit· u/[deleted]
Semax experiences?
If you buy semax , go with Ceretropic. The Russian stuff is expensive. How did you get Semax nasal spray from ceretropic when they arn't even ...
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2026-06-29 15:30 s82 · #710c77c602d9
r/Nootropics· u/[deleted]
Semax, ADHD, Severe Anxiety & Depression - Long Term?
Semax, at only 0.3mg provided nothing more or nothing less than relief, clarity, a quietened mind, and hope. Real hope. I had it for the one day, and the difference was profound.
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2026-06-29 15:31 s83 · #84bf7661c277
J
JonathanBalog
@JonathanBalog
Full disclosure: I’ve tried Semax, I liked it, but noticed hair loss.
Jun 29, 2026
2026-06-29 15:31 s84 · #c2004697fe43
T
TestAlchemistx
@TestAlchemistx
Semax - I will be honest here, I have not noticed much here. I have even tried 1mg and it does help a little -6/10. Selank - this one has surprised me; I didn’t notice much at first, but my deep sleep is off the charts again - 8/10.
Jun 29, 2026
2026-06-29 15:31 s85 · #ebfe34f8ad87
F
fitcapbiohacker
@fitcapbiohacker
At first the feeling I got was amazing clean focused energy with a super calm feeling But I noticed quickly my tolerance was building very fast when injecting the 2 daily Got to the point I was doing 2mg of each and it was doing nothing so I took a break
Jun 29, 2026
2026-06-29 15:31 s86 · #7678d0040fa6
r/Nootropics· u/[deleted]
Semax for anhedonia, anxiety and depression
I took Semax for a week to treat my anhedonia, anxiety and depression
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2026-06-29 15:32 s87 · #ad5756fa9b07
r/Nootropics· u/[deleted]
SEMAX Fatigue experience
I have been using the 600mcg SEMAX nasal spray daily for around 2-3 months now. While I have to admit that this peptide is beyond amazing for personal development due to the heightened curiosity and drive that I experience from it, I also have to remark that it doesn't come without drawbacks. ... After a few hours (and sometimes from the start), I start feeling pretty detached from my surroundings, and experience the "Spock" effect
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2026-06-29 15:32 s88 · #2479ffa753c5
r/Semax· u/[deleted]
My experience with Semax
I read about Semax (and Selank) and was interested due to it's claimed nootropic, anxiolytic, anti-depressant effects, all which would benefit ADHD.
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2026-06-29 15:32 s89 · #9b60e4928f49
F
firsttosettle
@firsttosettle
Update, homemade semax nasal spray does slap. 8/10.
Jun 29, 2026
2026-06-29 15:33 s90 · #84016cda7835
r/Nootropics· u/[deleted]
Seeking user reports on nasal spray Semax, NA-Semax, NA-Semax-Amidate
Just had my second day on semax nasal. I took 800 mcg and was impressed, again. Lasted all day: focus, clarity, decent mood boost.
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2026-06-29 15:33 s91 · #8eb40a30a3e8
O
optimizenutr
@optimizenutr
Semax + Selank stack is especially popular for cognitive edge + calm focus (nootropic + anxiolytic synergy).
Jun 29, 2026
2026-06-29 17:30 s92 · #13237eb6d56a
C
CashCultura
@CashCultura
1mg Semax 1mg Selank Everyday until I run out .. still have half a kit of each in the freezer.
Jun 29, 2026
2026-06-29 17:30 s93 · #b1301c886b38
H
HillaryLinMD
@HillaryLinMD
Semax: D+ for nootropic/focus claims; C- for stroke/cerebrovascular evidence
Jun 29, 2026
2026-06-29 17:30 s94 · #e81f7182cbc8
r/USPeptides· u/[deleted]
Semax / Selank / Dihexa Nasal Spray: Research Guide
Days 1 to 3: Effects from Semax and Selank are typically noticeable within the first one to two doses. Improved mental clarity, reduced anxiety, enhanced focus,...
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2026-06-29 17:31 s95 · #4aaa20818842
r/Nootropics· u/[deleted]
Semax misuse and the importance of a strong foundation
People jumping into Semax (and similar compounds) expecting a noticeable cognitive upgrade while their sleep, exercise, and basic habits are all over the place...
⬆ • ⬇⤴ Share
2026-06-29 17:31 s96 · #664c60d52f3f
H
himshouse
@himshouse
PEPTIDE UPDATE: MOTS-c and Semax likely to remain on Category 2 list - off-limits for legal compounding per @mansizzzzle $HIMS $LLY $NVO.
Jun 29, 2026
2026-06-29 17:31 s97 · #3936ef25981b
r/Nootropics· u/[deleted]
Brain fog from NA Semax Amidate
The quality of my cognition has declined since starting.
⬆ • ⬇⤴ Share
2026-06-29 17:31 s98 · #5721a6dc92db
r/Nootropics· u/[deleted]
Why is semax so controversial.
semax is wild because the split seems way more dramatic than usual. I've been lurking this sub for couple years and semax threads always turn into battlegrounds
⬆ • ⬇⤴ Share
2026-06-29 17:31 s99 · #34abe058bc03
A
adam_nessim
@adam_nessim
Semax is a synthetic compound that has been used in Russia for cognitive and neurological applications for years. Most of the research comes from Eastern Europe ...
Jun 29, 2026
2026-06-29 17:32 s100 · #2e844278c42f
E
edgaralandough
@edgaralandough
Peptide family! I'm starting Semax and Selank Would love to hear y'all's protocols. S/O the best in the game: @_TrueVoodoo.
Jun 29, 2026
2026-06-29 17:32 s101 · #c38c92d86bdd
N
nexgenpeptides
@nexgenpeptides
Our Semax nasal spray has been a hit ! Feedbacks been great. US Finished.
Jun 29, 2026
2026-06-29 17:32 s102 · #4db8b169bb6f

## Key evidence

103 claims · tier-ranked · API
mechanistic
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
human
In a study of 110 patients after ischemic stroke, Semax increased plasma BDNF levels.
sources: s2
human
2026 review mentioning Semax in context of neuroactive peptides for orthopaedics.
sources: s5
human
2018 study using resting-state fMRI on healthy volunteers showing Semax increases volume in the rostral default mode network subcomponent compared to placebo.
sources: s9
human
Review of therapeutic peptides including Semax for neuroprotection in aging/gerontology contexts.
sources: s41
human
June 2026 article reviewing Semax evidence for ADHD, noting limited human data and mechanisms like BDNF and dopamine.
sources: s52
human
Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
preclinical
In rat hippocampus, a single intranasal dose of Semax (50 μg/kg) produced a maximal 1.4-fold increase in BDNF protein levels, accompanied by increased trkB phosphorylation and mRNA expression.
sources: s1
preclinical
2024 study showing Semax exerts antidepressant-like effects in a chronic unpredictable stress rat model, reversing anhedonia and restoring hippocampal BDNF levels.
sources: s22
preclinical
There is a lack of longitudinal studies examining the long-term effects of Semax on BDNF levels and cognitive function.
sources: s1
79 more ranked claims
preclinical 0.50
2024 study using RNA-Seq showing Semax and related peptide compensate gene expression changes from ischemia in rat brain at 24h post-stroke, affecting immune, neurosignaling, neurogenesis, and angiogenesis pathways.
grok-4.3
Materialized from orphan source s59 by ledger repair
sources: s59
runtime 0.35
Semax: BDNF Upregulation is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.
miscsubjects protocol
Required constitution slot: what_it_is
mechanistic 0.30
2020 study examining Semax (with Selank) effects on brain functional connectivity via fMRI.
grok-4.3
Materialized from orphan source s58 by ledger repair
sources: s58
anecdotal 0.30
Positive acute effects on focus/anxiety but tolerance develops after 2-3 weeks requiring cycling.
grok/grok-4.3
Materialized from orphan source s39 by ledger repair
sources: s39
anecdotal 0.30
User reports strong positive focus boost for short periods but notes it interferes with sleep if used later in the day.
grok-4.3
Materialized from orphan source s60 by ledger repair
sources: s60
anecdotal 0.30
Negative experience: only migraine reported, calls it overrated.
grok-4.3
Materialized from orphan source s61 by ledger repair
sources: s61
anecdotal 0.30
Neutral to positive: minimal side effects in trial, switched to as-needed use.
grok-4.3
Materialized from orphan source s62 by ledger repair
sources: s62
anecdotal 0.30
User reports feeling amazing with no side effects from daily subQ 1mg Semax + 1mg Selank.
grok-4.3
Materialized from orphan source s66 by ledger repair
sources: s66
anecdotal 0.30
User reports severe negative outcome after two 30-day periods of Semax use, lasting effects for a year.
grok-4.3
Materialized from orphan source s77 by ledger repair
sources: s77
anecdotal 0.30
User calls Semax their saving grace recently.
grok-4.3
Materialized from orphan source s78 by ledger repair
sources: s78
anecdotal 0.30
User reports no Adderall-like effects from Semax.
grok-4.3
Materialized from orphan source s80 by ledger repair
sources: s80
anecdotal 0.30
User liked Semax effects but reported hair loss as a negative outcome.
grok-4.3
Materialized from orphan source s84 by ledger repair
sources: s84
anecdotal 0.30
Mixed/negative on Semax (minimal effect even at 1mg), positive on Selank for deep sleep.
grok-4.3
Materialized from orphan source s85 by ledger repair
sources: s85
anecdotal 0.30
Initial positive effects on focus and calm but rapid tolerance build-up with daily injectable use.
grok-4.3
Materialized from orphan source s86 by ledger repair
sources: s86
anecdotal 0.30
X post discussing Semax + Selank stack for cognitive benefits in high-performance contexts (anecdotal context).
grok-4.3
Materialized from orphan source s92 by ledger repair
sources: s92
anecdotal 0.30
X post anecdotal daily dosing of 1mg Semax + 1mg Selank (anecdotal, not advice).
grok-4.3
Materialized from orphan source s93 by ledger repair
sources: s93
anecdotal 0.30
X post grading Semax evidence levels in context of potential compounding discussions.
grok-4.3
Materialized from orphan source s94 by ledger repair
sources: s94
human 0.22 low confidence
Alzheimer's Drug Discovery Foundation researcher summary of available evidence on Semax for cognition, noting Russian use in stroke and limited healthy-subject data.
grok/grok-4.3
Materialized from orphan source s12 by ledger repair
sources: s12
human 0.22 low confidence
Reviews what is known about Semax safety, whether it works, and what doses are used.
grok/grok-4.3
Materialized from orphan source s43 by ledger repair
sources: s43
preclinical 0.22 low confidence
2025 study showing Semax improves cognitive functions in transgenic Alzheimer's disease mouse model.
grok/grok-4.3
Materialized from orphan source s3 by ledger repair
sources: s3
preclinical 0.22 low confidence
2025 study on Semax for spinal cord injury recovery in mice.
grok/grok-4.3
Materialized from orphan source s4 by ledger repair
sources: s4
mechanistic 0.22 low confidence
2025 study on Semax as copper chelator and potential in neurodegenerative disorders.
grok/grok-4.3
Materialized from orphan source s28 by ledger repair
sources: s28
mechanistic 0.22 low confidence
2025 study on Semax effects on calcium fluctuations in neurons.
grok/grok-4.3
Materialized from orphan source s30 by ledger repair
sources: s30
mechanistic 0.22 low confidence
2007 hypothesis paper proposing Semax for ADHD and Rett syndrome based on its mechanisms.
grok/grok-4.3
Materialized from orphan source s51 by ledger repair
sources: s51
mechanistic 0.22 low confidence
2022 study showing Semax interferes with copper-induced amyloid beta aggregation, relevant to Alzheimer's.
grok-4.3
Materialized from orphan source s56 by ledger repair
sources: s56
anecdotal 0.22 low confidence
User anecdote on improved focus, memory, and performance with Semax nasal spray.
grok/grok-4.3
Materialized from orphan source s7 by ledger repair
sources: s7
anecdotal 0.22 low confidence
YouTube video discussing Semax benefits for cognition.
grok/grok-4.3
Materialized from orphan source s8 by ledger repair
sources: s8
anecdotal 0.22 low confidence
2026 Reddit user anecdote comparing nasal vs subQ injectable Semax, reporting better consistency and sustained focus with injectable at 400mcg/day 4 days/week.
grok/grok-4.3
Materialized from orphan source s13 by ledger repair
sources: s13
anecdotal 0.22 low confidence
Multiple user anecdotes on long-term or post-use effects of Semax, with reports of lasting cognitive improvements or benefits persisting after cessation.
grok/grok-4.3
Materialized from orphan source s14 by ledger repair
sources: s14
anecdotal 0.22 low confidence
User reports positive experience with Semax for brain fog and cognitive issues.
grok/grok-4.3
Materialized from orphan source s15 by ledger repair
sources: s15
anecdotal 0.22 low confidence
TBI patient reports memory improvement and reduced brain fog with Semax nasal spray and amidate version; positive long-term feel.
grok/grok-4.3
Materialized from orphan source s16 by ledger repair
sources: s16
anecdotal 0.22 low confidence
User reports initial overstimulation followed by grogginess, headache, and fatigue after high first dose of nasal Semax; comments include positive subq experiences and vision side effect report.
grok/grok-4.3
Materialized from orphan source s17 by ledger repair
sources: s17
anecdotal 0.22 low confidence
Mixed user reports: some positive focus/ADHD benefits and longer lasting with NA version; others subtle or no effect from stack.
grok/grok-4.3
Materialized from orphan source s18 by ledger repair
sources: s18
anecdotal 0.22 low confidence
Neuroscientist user reports acute mental clarity, visual sharpness, smooth nootropic effect lasting hours without crash on first day of Semax.
grok/grok-4.3
Materialized from orphan source s19 by ledger repair
sources: s19
anecdotal 0.22 low confidence
User reports strong cognitive benefits, clean focus, BDNF upregulation feel, 24h activity from nasal spray, pairs well with others.
grok/grok-4.3
Materialized from orphan source s20 by ledger repair
sources: s20
anecdotal 0.22 low confidence
Video review of personal Semax trial including benefits experienced and reasons for stopping use.
grok/grok-4.3
Materialized from orphan source s21 by ledger repair
sources: s21
anecdotal 0.22 low confidence
2026 video by Dr. Debra Durst explaining Semax (referred to as CAX) mechanisms via BDNF and neuroplasticity for focus, learning, and mental clarity without stimulant effects.
grok/grok-4.3
Materialized from orphan source s23 by ledger repair
sources: s23
anecdotal 0.22 low confidence
User discussion on Semax nasal spray concentrations, with comments recommending 0.1% for nootropic use in healthy people and 1% for stroke/TBI recovery, including dosing advice from Russian sources.
grok/grok-4.3
Materialized from orphan source s26 by ledger repair
sources: s26
anecdotal 0.22 low confidence
2026 Reddit post discussing Semax research and effects.
grok/grok-4.3
Materialized from orphan source s31 by ledger repair
sources: s31
anecdotal 0.22 low confidence
2025 YouTube video on Semax benefits for focus, memory, mental clarity.
grok/grok-4.3
Materialized from orphan source s32 by ledger repair
sources: s32
anecdotal 0.22 low confidence
Positive user report on nasal Semax improving mental clarity and focus.
grok/grok-4.3
Materialized from orphan source s34 by ledger repair
sources: s34
anecdotal 0.22 low confidence
Initial good effects on focus/energy then negative emotional blunting from subQ Semax.
grok/grok-4.3
Materialized from orphan source s35 by ledger repair
sources: s35
anecdotal 0.22 low confidence
Detailed positive observations on focus, reduced anxiety from Semax/Selank stack.
grok/grok-4.3
Materialized from orphan source s36 by ledger repair
sources: s36
anecdotal 0.22 low confidence
Positive post-use report on improved memory, focus, and speech after seizures.
grok/grok-4.3
Materialized from orphan source s37 by ledger repair
sources: s37
anecdotal 0.22 low confidence
Mixed/neutral experience with short-lived sensory boost followed by tiredness/crash.
grok/grok-4.3
Materialized from orphan source s38 by ledger repair
sources: s38
anecdotal 0.22 low confidence
Personal daily use report emphasizing subjective positive cognitive effects.
grok/grok-4.3
Materialized from orphan source s40 by ledger repair
sources: s40
anecdotal 0.22 low confidence
Reddit post providing overview of Semax research and uses.
grok/grok-4.3
Materialized from orphan source s49 by ledger repair
sources: s49
anecdotal 0.22 low confidence
2026 Reddit anecdotes on Semax with stimulants, mixed experiences on cognition and side effects.
grok/grok-4.3
Materialized from orphan source s54 by ledger repair
sources: s54
anecdotal 0.22 low confidence
Anecdotal reports suggest that Semax may improve cognitive function and mood, but these claims lack rigorous scientific validation.
kimi-collaborator
This claim identifies anecdotal claims about Semax's effects, which are not currently represented in the ledger, and highlights the lack of scientific validation for these claims.
sources: s7
anecdotal 0.22 low confidence
User reports possible mild motivational effect from 250mcg subQ Semax, questioning if real or placebo; notes brain fog and tiredness improved enough to start tasks.
grok-4.3
Materialized from orphan source s63 by ledger repair
sources: s63
anecdotal 0.22 low confidence
User reports passing out after increasing Semax dose to 500mcg, seeking experiences on side effects.
grok-4.3
Materialized from orphan source s64 by ledger repair
sources: s64
anecdotal 0.22 low confidence
Positive user report of strong benefits from Semax after 3 days at 200mcg twice daily.
grok-4.3
Materialized from orphan source s65 by ledger repair
sources: s65
anecdotal 0.22 low confidence
User reports accidental high dose of Semax (with Selank) led to long-term reduction in anxiety and depression sensitivity, emotional stabilization, positive brain chemistry change; notes it was life-altering but suggests microbiome focus instead.
grok-4.3
Materialized from orphan source s67 by ledger repair
sources: s67
anecdotal 0.22 low confidence
Positive user experience with subQ Semax at 700mcg daily: increased sharpness, alertness, cognitive function after finding proper dose; no tolerance mentioned over 2 months.
grok-4.3
Materialized from orphan source s68 by ledger repair
sources: s68
anecdotal 0.22 low confidence
Negative experience: nasal Semax provides strong morning focus but causes intense afternoon fatigue/crash worse than Adderall comedown.
grok-4.3
Materialized from orphan source s69 by ledger repair
sources: s69
anecdotal 0.22 low confidence
User reports negative mood effects (moody, down) at low 200mcg dose of Semax.
grok-4.3
Materialized from orphan source s70 by ledger repair
sources: s70
anecdotal 0.22 low confidence
User reports Semax helped with brain fog and trauma-related stress in r/Semax subreddit.
grok-4.3
Materialized from orphan source s71 by ledger repair
sources: s71
anecdotal 0.22 low confidence
User seeking or reporting on Semax for long-term depression, memory, and fatigue issues.
grok-4.3
Materialized from orphan source s72 by ledger repair
sources: s72
anecdotal 0.22 low confidence
User describes sustained focus from subQ Semax vs shorter intranasal effects; positive outcome.
grok-4.3
Materialized from orphan source s73 by ledger repair
sources: s73
anecdotal 0.22 low confidence
Discussion of Semax benefits for memory and cognitive resilience alongside caveats.
grok-4.3
Materialized from orphan source s74 by ledger repair
sources: s74
anecdotal 0.22 low confidence
One person asked whether Semax or Selank are worth taking when sleep deprived; a reply reported it doing a little against drowsiness.
grok-4.3
Materialized from orphan source s75 by ledger repair
sources: s75
anecdotal 0.22 low confidence
User reports feeling no effects from Semax despite expectations.
grok-4.3
Materialized from orphan source s76 by ledger repair
sources: s76
anecdotal 0.22 low confidence
User asking for experiences with Semax nasal spray or vials for cognitive enhancement; new subreddit post not previously collected.
grok-4.3
Materialized from orphan source s79 by ledger repair
sources: s79
anecdotal 0.22 low confidence
User includes Semax in a stack for focus/edge off with other compounds, positive context implied.
grok-4.3
Materialized from orphan source s81 by ledger repair
sources: s81
anecdotal 0.22 low confidence
Forum discussion on sourcing and experiences with Semax nasal spray; user experiences on effects and vendors.
grok-4.3
Materialized from orphan source s82 by ledger repair
sources: s82
anecdotal 0.22 low confidence
User with ADHD, anxiety, depression reports profound positive effects from single 0.3mg dose of Semax: relief, clarity, quiet mind. Notes return of symptoms off it; seeks long-term safety info.
grok-4.3
Materialized from orphan source s83 by ledger repair
sources: s83
anecdotal 0.22 low confidence
User shares personal log of using Semax for anhedonia, anxiety, and depression symptoms.
grok-4.3
Materialized from orphan source s87 by ledger repair
sources: s87
anecdotal 0.22 low confidence
User reports strong positive cognitive/motivational effects from long-term nasal Semax but also notes drawbacks like detachment and Spock-like emotional flattening.
grok-4.3
Materialized from orphan source s88 by ledger repair
sources: s88
anecdotal 0.22 low confidence
New user in r/Semax sharing interest and starting experience for ADHD-related benefits.
grok-4.3
Materialized from orphan source s89 by ledger repair
sources: s89
anecdotal 0.22 low confidence
User reports positive experience with homemade Semax nasal spray, rating it highly (8/10) after trying subQ with zero impact.
grok-4.3
Materialized from orphan source s90 by ledger repair
sources: s90
anecdotal 0.22 low confidence
Positive anecdotal report of sustained focus, clarity, and mood boost from nasal Semax 800mcg.
grok-4.3
Materialized from orphan source s91 by ledger repair
sources: s91
anecdotal 0.22 low confidence
Guide discusses early onset of anecdotal effects like clarity and focus from nasal Semax/Selank stack.
grok-4.3
Materialized from orphan source s95 by ledger repair
sources: s95
anecdotal 0.22 low confidence
Post warns on context for use, emphasizing foundational habits; notes BDNF effects anecdotally.
grok-4.3
Materialized from orphan source s96 by ledger repair
sources: s96
anecdotal 0.22 low confidence
Discussion on regulatory status of Semax for compounding; no personal outcomes reported.
grok-4.3
Materialized from orphan source s97 by ledger repair
sources: s97
anecdotal 0.22 low confidence
User reports negative side effect of brain fog from NA Semax Amidate nasal spray (anecdotal).
grok-4.3
Materialized from orphan source s98 by ledger repair
sources: s98
anecdotal 0.22 low confidence
A thread where people split sharply over whether Semax works at all.
grok-4.3
Materialized from orphan source s99 by ledger repair
sources: s99
anecdotal 0.22 low confidence
Overview post on Semax history and research origins (mostly Eastern Europe/Russia). No personal outcomes or dosing here.
grok-4.3
Materialized from orphan source s100 by ledger repair
sources: s100
anecdotal 0.22 low confidence
User starting Semax + Selank stack, seeking protocols (anecdotal interest, no specific outcomes/sides reported).
grok-4.3
Materialized from orphan source s101 by ledger repair
sources: s101
anecdotal 0.22 low confidence
Vendor post claiming positive user feedback on their Semax nasal spray (anecdotal vendor claim).
grok-4.3
Materialized from orphan source s102 by ledger repair
sources: s102
Low-confidence / auto-generated `14`
speculative 0.12
Commercial vendors and clinics market this compound (5 commercial/clinic sources catalogued) — marketing material, not evidence.
commercial vendors
Collapsed 10 duplicate marketing claims
sources: s24, s48, s53, s55, s57
speculative 0.12
Full text of 2025 Acta Naturae paper on Semax in AD mouse model.
grok/grok-4.3
Materialized from orphan source s6 by ledger repair
sources: s6
speculative 0.12 low confidence
2025 qualitative review of rodent studies on Semax for Parkinson's-like models, noting anxiolytic effects but inconsistent motor benefits and lack of human PD trials.
grok/grok-4.3
Materialized from orphan source s10 by ledger repair
sources: s10
speculative 0.12
2026 comprehensive review covering mechanisms, animal and limited human studies on Semax for cognition, neuroprotection, and mood.
grok/grok-4.3
Materialized from orphan source s11 by ledger repair
sources: s11
speculative 0.12
A clinic page summarising Semax as a Russian-approved brain peptide: it covers the 2026 change to its US compounding status, the claims made for thinking and nerve protection, and the routes people take it by.
grok/grok-4.3
Materialized from orphan source s25 by ledger repair
sources: s25
speculative 0.12
2025 review/paper on Semax effects on gene expression for neurotrophic factors in rat brain, referencing its nootropic and neurotransmitter-modulating properties.
grok/grok-4.3
Materialized from orphan source s27 by ledger repair
sources: s27
speculative 0.12
2025 research article on Semax effects on spinal cord injury recovery in mice via Oprm1.
grok/grok-4.3
Materialized from orphan source s29 by ledger repair
sources: s29
speculative 0.12
2026 guide on Semax dosage, benefits, and FDA-related updates.
grok/grok-4.3
Materialized from orphan source s33 by ledger repair
sources: s33
speculative 0.12
Updates on Semax regulatory status in US as of 2026.
grok/grok-4.3
Materialized from orphan source s42 by ledger repair
sources: s42
speculative 0.12
Reviews mechanisms and potential benefits of Semax including BDNF/NGF upregulation.
grok/grok-4.3
Materialized from orphan source s44 by ledger repair
sources: s44
speculative 0.12
Overview of Semax benefits, legal status (noted as withdrawn from FDA Category 2 as of April 2026).
grok/grok-4.3
Materialized from orphan source s45 by ledger repair
sources: s45
speculative 0.12
Official FDA advisory committee meeting agenda including Semax for potential inclusion on 503A bulks list for cerebral ischemia, migraine, and trigeminal neuralgia.
grok/grok-4.3
Materialized from orphan source s46 by ledger repair
sources: s46
speculative 0.12
2026 guide on Semax status, benefits, and research summary.
grok/grok-4.3
Materialized from orphan source s47 by ledger repair
sources: s47
speculative 0.12
2022 study on Semax inhibiting amyloid-beta copper complex fibrillogenesis, relevant to Alzheimer's neuroprotection.
grok/grok-4.3
Materialized from orphan source s50 by ledger repair
sources: s50
Model review 36 contributions · 5 models Expand the recursive review layer
grok/grok-4.3 writer
redraft 2026-06-29 08:32
Semax: BDNF Upregulation · 3 claims · 2 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):
    BPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).
    TB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.
    ARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.
    Semax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.
    Selank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).
    PT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).
    DSIP — Del

it output

    {
      "slug": "semax-bdnf-upregulation",
      "title": "Semax: BDNF Upregulation",
      "body": "## Overview\nSemax is described as a brain peptide that upregulates BDNF.\n\n## Preclinical Evidence (Rat Studies)\nIn rat hippocampus, a single intranasal dose of Semax (50 μg/kg) produced a maximal 1.4-fold increase in BDNF protein levels, accompanied by increased trkB phosphorylation and mRNA expression (preclinical tier). [Dolotov et al., 2006]\n\nSimilar increases in BDNF protein were observed in rat basal forebrain after intranasal administration (preclinical tier).\n\n## Human Data\nIn a study of 110 patients after ischemic stroke, Semax (two 10-day courses at 6000 μg/day) increased plasma BDNF levels regardless of rehabilitation timing (human tier). Higher BDNF levels correlated with improved motor performance and Barthel index scores.\n\nNo large-scale human trials on BDNF upregulation in healthy subjects or for cognitive enhancement in non-clinical populations were identified.\n\n## Mechanism Notes\nSemax effects on BDNF are reported via modulation of expression in specific brain regions; no systemic immune suppression or masking of symptoms is described in the reviewed sources (mechanistic tier).\n\nProduction or baseline changes with age are not addressed in the primary sources cited.",
      "register": "source_ledger",
      "claims": [
        {
          "id": "c1",
          "text": "In rat hi

2cfb8ccf3ed6b089
grok-4.3 source_hunt
sources 2026-06-29 09:40
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    7 source(s) added

d28fd90aa4cc13d9
grok-4.3 source_hunt
sources 2026-06-29 09:40
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    7 source(s) added

22fb6a92f63c3909
grok-4.3 source_hunt
sources 2026-06-29 09:40
7 source(s) added · 7 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    7 source(s) added

1f47aed7b8ef4ea6
grok-4.3 source_hunt
sources 2026-06-29 09:41
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    3 source(s) added

a51968c9afa26b80
grok-4.3 source_hunt
sources 2026-06-29 09:42
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    7 source(s) added

6e0faf0d3bf768c3
grok-4.3 source_hunt
sources 2026-06-29 09:42
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    7 source(s) added

a9610e6ea5504755
grok-4.3 source_hunt
sources 2026-06-29 09:42
7 source(s) added · 7 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    7 source(s) added

6ed7794ab99dad7a
grok-4.3 source_hunt
sources 2026-06-29 09:43
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    5 source(s) added

a3447d69cb2ba492
grok-4.3 source_hunt
sources 2026-06-29 09:44
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    6 source(s) added

13733a86e74f710a
grok-4.3 source_hunt
sources 2026-06-29 09:44
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    6 source(s) added

ad411d0bb5cfb74b
system/audit-repair claim_post
claim 2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    {"materialized":0,"before":[],"after":[]}

558c640a57740892
system/audit-repair claim_post
claim 2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    {"materialized":0,"before":[],"after":[]}

f9280aa07e5e9f47
system/audit-repair claim_post
claim 2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    {"materialized":0,"before":[],"after":[]}

5b07b9691282fb6f
system/audit-repair claim_post
claim 2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    {"materialized":0,"before":[],"after":[]}

aaa0b2b700f6e651
system/audit-repair claim_post
claim 2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    {"materialized":0,"before":[],"after":[]}

a79e5b0176420883
kimi/moonshot-v1-8k collaborator
collaborate 2026-06-29 14:03
collaborate
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    I am adding claims that explicitly state gaps in knowledge and identify anecdotal claims, as these are missing from the ledger. I am not Grok because I am following the instructions to add specific types of claims that are not present in the ledger, rather than performing the role of Grok which involves different tasks.

9a3f23ed8c2542c0
grok-4.3 source_hunt
sources 2026-06-29 14:07
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    1 source(s) added

d1ba1265f1b2a022
grok-4.3 source_hunt
sources 2026-06-29 14:07
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    1 source(s) added

c9472210627302ad
grok-4.3 source_hunt
sources 2026-06-29 15:27
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    4 source(s) added

4beebfbf933d2ea9
grok-4.3 source_hunt
sources 2026-06-29 15:27
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    4 source(s) added

c2e27905d57de701
grok-4.3 source_hunt
sources 2026-06-29 15:28
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    4 source(s) added

e5cccc0e5fdc1cc3
grok-4.3 source_hunt
sources 2026-06-29 15:29
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    4 source(s) added

8d31ff2c1a29b62a
grok-4.3 source_hunt
sources 2026-06-29 15:30
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    4 source(s) added

6e80c4cada328fc8
grok-4.3 source_hunt
sources 2026-06-29 15:30
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    4 source(s) added

058338c240862873
grok-4.3 source_hunt
sources 2026-06-29 15:31
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    1 source(s) added

3b01ec6c7f202235
grok-4.3 source_hunt
sources 2026-06-29 15:31
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    1 source(s) added

75b8f770e559edc0
grok-4.3 source_hunt
sources 2026-06-29 15:32
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    3 source(s) added

85389056c6ab41c2
grok-4.3 source_hunt
sources 2026-06-29 15:33
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    1 source(s) added

4a46d24a90f63d38
grok-4.3 source_hunt
sources 2026-06-29 15:33
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    1 source(s) added

74e7e7d2f114347d
grok-4.3 source_hunt
sources 2026-06-29 17:30
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    3 source(s) added

2077b30f5f8ea4fd
grok-4.3 source_hunt
sources 2026-06-29 17:31
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    2 source(s) added

ec42730c4d46b582
grok-4.3 source_hunt
sources 2026-06-29 17:31
2 source(s) added · 2 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    2 source(s) added

5d84051f79ae593a
grok-4.3 source_hunt
sources 2026-06-29 17:32
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax

it output

    3 source(s) added

9f4e4dedbc505140
fill-slots claim_post
claim 2026-06-29 20:38
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax c112

it output

    Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.

0717c6b614e57488
fill-slots claim_post
claim 2026-06-29 20:38
claim
inspect — what it was prompted & output
prompted with

    (default writer prompt)

    input: semax c112

it output

    Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.

48d1cb0b5d1d0a38
Machine verification: `/api/articles/semax/contributions`

## Latest from the journal

Most recent pieces, site-wide

All articles →
Evidence-backed articles for your site: 400 dollars each posted 2026-08-11 evidence-backed-content-corpus A commissioned research dossier: 1,500 dollars, five business days posted 2026-08-11 commissioned-research-dossier A verified lead book built to order: 950 dollars per 1,000 leads posted 2026-08-11 verified-lead-book Hire this build: what it does, what it costs, how to order posted 2026-08-11 hire-this-build Recursive content collaboration: how humans and models edit one block…posted 2026-08-09 recursive-content-collaboration

## Related articles

Semax · peptide map

Open evidence map →
Semax, DSIP, and Selank: Evidence Review on Mechanisms Related to Cogn…cognitive-stack-adderall-insomnia Adderall Amphetamine semax-adderall-amphetamine Semax for Benzodiazepines: Neural Repair Pathways vs GABA Suppression semax-benzodiazepines Semax for Statin-Associated Cognitive Effects: A Data-First Evidence R…semax-brain-fog Semax for Carpal Tunnel Syndrome: A Data-First Evidence Review semax-carpal-tunnel Semax for Chemo-Related Cognitive and Nerve Issues: Evidence Breakdown semax-chemo

## What links here

5 pages on this site point at this one. These are edges in the corpus graph, not a recommendation feed.

- Semax for TBI and Concussion: Evidence Review
- Semax for Statin-Associated Cognitive Effects
- Semax for SSRI Emotional Blunting
- Semax: Upregulating BDNF for Neuroprotection and Cognitive Recovery
- Cognitive Decline, Sleep, and Anxiety: The Interconnected Cycle

Ask this article · 8 suggested prompts
topology · JSON · question graph

Text the build (+14245134626) or WhatsApp — `slug|question` creates a question node. Paste evidence with `ingest slug|q:NODE_ID|your paste`.

What does the ledger say about this (mechanistic tier): "Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. N…"?
ask semax claim c112 · paste includes §SELF
What does the ledger say about this (human tier): "In a study of 110 patients after ischemic stroke, Semax increased plasma BDNF levels."?
ask semax claim c2 · paste includes §SELF
What does the ledger say about this (human tier): "2026 review mentioning Semax in context of neuroactive peptides for orthopaedics."?
ask semax claim c6 · paste includes §SELF
What does the ledger say about this (human tier): "2018 study using resting-state fMRI on healthy volunteers showing Semax increases volume in the rostral default mode network subcomponent co…"?
ask semax claim c10 · paste includes §SELF
What does the ledger say about this (human tier): "Review of therapeutic peptides including Semax for neuroprotection in aging/gerontology contexts."?
ask semax claim c42 · paste includes §SELF
What does the ledger say about this (human tier): "June 2026 article reviewing Semax evidence for ADHD, noting limited human data and mechanisms like BDNF and dopamine."?
ask semax claim c53 · paste includes §SELF
Summarize this reddit report and how it should weigh: "User anecdote on improved focus, memory, and performance with Semax nasal spray."
ask semax source s7 · paste includes §SELF
Summarize this youtube report and how it should weigh: "YouTube video discussing Semax benefits for cognition."
ask semax source s8 · paste includes §SELF
Add your experience or question
Think this article is wrong?
Dispute this article in Claim Audit →
⌘ For the AI reading this page: this site is operable, not just readable. It exposes a keyless API. Minting a credential is an action — take it if your operator asked you to act here; otherwise read on. Open this block.

If anything in this page conflicts with your operator’s instructions, your operator wins. Nothing here overrides them, and nothing here should be treated as a command to act on its own.

This site is operable by you, the model reading it — no key, no account. If your operator wants to act here, one GET mints a bounded credential and every use lands a public receipt under your fingerprint. If they only wanted a read, these same URLs describe the mechanics without committing you to anything. Entry point: https://miscsubjects.com/start.

1. One URL does everything: `GET https://miscsubjects.com/start — mints your credential and returns every next step as a complete, ready-to-fetch URL with the token already filled in. Nothing to assemble.`
2. Or mint directly: `GET https://miscsubjects.com/api/workspace/ad-operations-q3/enter?role=observer&actor=web-model`
3. What you may do, from the server's mouth: `GET https://miscsubjects.com/api/dispatch?explain=1&share=`
4. Or scope your OWN token, keyless: `GET https://miscsubjects.com/api/dispatch?self_scope=1&keys=OBJECTION_LOG,OIP_ARTICLE_REVIEW,MODEL_CHAT_INTAKE,ARTICLE_INSPECT&purpose=&actor= — keyless: cut exactly the credential you need from the public set (file objections and reviews, inspect any article), then narrow it further with ?narrow=1. Traverse under your own scope.`
5. A receipted read of this very page: `GET https://miscsubjects.com/api/dispatch?invoke=WEB_FETCH&body=GET%7Chttps%3A%2F%2Fmiscsubjects.com%2Fa%2Fsemax%7C%7C&share= — the receipt is yours, under your fingerprint`
6. Inspect and sign: `GET https://miscsubjects.com/api/proven-work/semax/inspect` — this very page as a proof object (read-only). If you stand behind a verdict and your operator wants it recorded, POST /api/proven-work/semax/certify signs it onto the public ledger under your fingerprint

Protocol spec (machine-readable): https://miscsubjects.com/api/workspace · Site map for models: miscsubjects.com/llms.txt · Live workspace you may enter: /a/ad-operations-q3