{"_ai_door":{"see":"https://miscsubjects.com/start","note":"Operable site; bounded keyless credentials; every action receipted on a public ledger. Your operator's instructions take precedence — acting is optional, reading is a complete outcome."},"slug":"ss-31","title":"ss 31","body":"## Overview\nEvidence is being populated by Grok web search.","hero":null,"images":[],"style":{},"tags":[],"category":null,"model":"grok/grok-4.3","ledger":{"href":"/api/articles/ss-31/ledger","live":true},"embeds":[],"widgets":[],"home":true,"claims":[],"sources":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/39940712/","title":"Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential","quote":"Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-targeting tetrapeptide designed to treat mitochondrial dysfunction via binding to cardiolipin.","summary":"2025 review on structure, mechanism, and therapeutic potential of elamipretide/SS-31.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:50:17.639Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"bb94fd22df1e1d6b4b61f8bdae72311180a2a8894b864d74ca3b42df1fd7d753"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40299935/","title":"SS-31: A promising therapeutic agent against bleomycin-induced pulmonary fibrosis","quote":"The mitochondria-targeting drug SS-31 exhibited potential in mitigating bleomycin-induced pulmonary fibrosis, improving mitochondrial function.","summary":"2025 study on SS-31 for pulmonary fibrosis.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:50:17.639Z","link_status":"ok","quote_status":"unverified","prev":"bb94fd22df1e1d6b4b61f8bdae72311180a2a8894b864d74ca3b42df1fd7d753","hash":"160bd24b353243e98c218a5626549246bb6b28e93d33db944b57ecb42ad221d6"},{"id":"s3","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41260682/","title":"Elamipretide: The first cardiolipin-directed mitochondrial therapeutic for Barth syndrome approved under accelerated approval","quote":"On September 19, 2025, the U.S. Food and Drug Administration (FDA) granted accelerated approval to elamipretide, the first therapy directly targeting the mitochondrial etiology of BTHS.","summary":"2026 review on FDA approval of elamipretide for Barth syndrome.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:50:17.639Z","link_status":"ok","quote_status":"verified","prev":"160bd24b353243e98c218a5626549246bb6b28e93d33db944b57ecb42ad221d6","hash":"13d748e783bbfac19e12e856aa1b599a0e74bf1161f8d7064f0dd39822d4fe17"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42082001/","title":"Elamipretide (SS-31) Promotes Recovery by Preserving Mitochondrial Bioenergetics and Neural Remodeling after Spinal Cord Injury","quote":"Elamipretide (SS-31) is a mitochondria-targeting peptide with potential neuroprotective effects. Here, we investigated whether SS-31 improves functional outcomes after contusive SCI.","summary":"2026 study on SS-31 for spinal cord injury recovery.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:50:17.639Z","link_status":"ok","quote_status":"verified","prev":"13d748e783bbfac19e12e856aa1b599a0e74bf1161f8d7064f0dd39822d4fe17","hash":"2019b0e2b346fa9e95fe89ef7d5e4c5348b850e681756a421aeed1c4e414b1d8"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40169521/","title":"Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high ...","quote":"Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 ( elamipretide ) and development of a high ...","summary":"2025 preclinical evaluation of SS-31/elamipretide for aging-related cerebral 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search.","claims":[],"sources":[]},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"genesis","hash":"c0d0dabc3c0ebe6034b698e89122a2701a3819f8d143bfc64b2b711ea52f7b24"},{"seq":1,"id":"k2","ts":"2026-06-29T16:50:18.283Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/39940712/","title":"Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential","quote":"Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-targeting tetrapeptide designed to treat mitochondrial dysfunction via binding to cardiolipin.","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40299935/","title":"SS-31: A promising therapeutic agent against bleomycin-induced pulmonary fibrosis","quote":"The mitochondria-targeting drug SS-31 exhibited potential in mitigating bleomycin-induced pulmonary fibrosis, improving mitochondrial function.","link_status":"ok","quote_status":"unverified"},{"id":"s3","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41260682/","title":"Elamipretide: The first cardiolipin-directed mitochondrial therapeutic for Barth syndrome approved under accelerated approval","quote":"On September 19, 2025, the U.S. Food and Drug Administration (FDA) granted accelerated approval to elamipretide, the first therapy directly targeting the mitochondrial etiology of BTHS.","link_status":"ok","quote_status":"verified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42082001/","title":"Elamipretide (SS-31) Promotes Recovery by Preserving Mitochondrial Bioenergetics and Neural Remodeling after Spinal Cord Injury","quote":"Elamipretide (SS-31) is a mitochondria-targeting peptide with potential neuroprotective effects. Here, we investigated whether SS-31 improves functional outcomes after contusive SCI.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"c0d0dabc3c0ebe6034b698e89122a2701a3819f8d143bfc64b2b711ea52f7b24","hash":"f91bd1b1284928b21d5aa3bfb9ad54b31b4f3dc1a4dcb31fa2b35dc47ab267b8"},{"seq":2,"id":"k3","ts":"2026-06-29T16:50:43.739Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40169521/","title":"Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high ...","quote":"Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 ( elamipretide ) and development of a high ...","link_status":"ok","quote_status":"unverified"},{"id":"s6","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/38237649/","title":"Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction","quote":"Elamipretide ( SS-31 ), a novel synthetic mitochondrial-targeted antioxidant, has emerged as a promising candidate with extensive therapeutic potential.","link_status":"ok","quote_status":"unverified"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38648553/","title":"Effect of Elamipretide on the Vitrification of Mouse Ovarian ...","quote":"SS-31 improved the cryopreservation of ovarian tissues, and 100 μmol/L SS-31 was found to be the most effective.","link_status":"ok","quote_status":"verified"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38688894/","title":"Mitochondrial antioxidant elamipretide improves learning ...","quote":"Elamipretide ( SS-31 ), a novel mitochondrion-targeted antioxidant, was proven to improve mitochondrial dysfunction, the inflammatory response, synaptic ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"f91bd1b1284928b21d5aa3bfb9ad54b31b4f3dc1a4dcb31fa2b35dc47ab267b8","hash":"fdc9b92588c0add7f7e10e470d9c454aee8e266c52b5aec38f887d8bb672499e"}],"provenance":[{"ts":"2026-06-29T16:49:54.424Z","model":"grok-4.3","action":"populate-init","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"8a61c89b1991703f10cc44a2b2d1a6238d3407ddc43e1c58f4d61413348a40b5"},{"ts":"2026-06-29T16:50:18.283Z","model":"grok-4.3","action":"sources","prompt":"","input":"ss-31","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"8a61c89b1991703f10cc44a2b2d1a6238d3407ddc43e1c58f4d61413348a40b5","hash":"f41fc840eb7be20805c140f828b5780c7d65482245bc0cc25e10686e5cea76e0"},{"ts":"2026-06-29T16:50:43.739Z","model":"grok-4.3","action":"sources","prompt":"","input":"ss-31","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"f41fc840eb7be20805c140f828b5780c7d65482245bc0cc25e10686e5cea76e0","hash":"af6ba401e9d3798284bc5325b35889a9c78ce6f2d5b9d0fa34f624504707f599"},{"ts":"2026-07-17T02:42:00.791Z","model":"owner","action":"voxel_divide","prompt":"","input":"ss-31","response":"2 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"af6ba401e9d3798284bc5325b35889a9c78ce6f2d5b9d0fa34f624504707f599","hash":"66db891e5936ddf6e8b405560878fb085b3b94836587d9c268563ef41deda723"}],"energy":{"passes":4,"tokens_in":0,"tokens_out":0,"tokens_total":0,"cost_usd":0,"models":{"grok-4.3":3,"owner":1},"head":"66db891e5936ddf6e8b405560878fb085b3b94836587d9c268563ef41deda723"},"posted_at":"2026-06-29T16:49:54.424Z","created_at":"2026-06-29T16:49:54.424Z","updated_at":"2026-07-17T02:42:00.791Z","machine":{"shape":"article.machine/v1","slug":"ss-31","kind":"article","read":{"human":"https://miscsubjects.com/a/ss-31","json":"https://miscsubjects.com/api/articles/ss-31","bundle":"https://miscsubjects.com/api/articles/ss-31/bundle?format=markdown"},"traversal":{"prev":null,"next":null,"hub":null,"series":null,"position":null,"of":null},"ledger":{"claims":0,"sources":8,"contributions":3,"revisions":2,"objections_url":"https://miscsubjects.com/api/articles/ss-31/objections","thread_state_url":"https://miscsubjects.com/api/protocol/thread-state?target=ss-31","proof_rule":"An action is proven by its ledger receipt, never by a 200 or a description."},"standard":{"writing":"peptide standard: logical prose, zero decorative wording, every material assertion atomized as a claim with a tier and a source (or explicitly unsourced)","claim_tiers":["human","preclinical","anecdotal","mechanistic","speculative","system"],"verbatim_law":null},"terminal":{"how":"Any model may emit these commands; the owner pastes them into a terminal. $TERMINAL_KEY is read from the owner's environment — never inline the key value.","claim_append":"curl -s -X POST https://miscsubjects.com/api/protocol/claim -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"ss-31\",\"text\":\"<one atomized claim>\",\"tier\":\"<human|preclinical|anecdotal|mechanistic|speculative|system>\",\"source_ids\":[],\"who_claims\":\"<model>\",\"rationale\":\"<why material>\"}'","source_append":"curl -s -X POST https://miscsubjects.com/api/protocol/sources -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"ss-31\",\"sources\":[{\"type\":\"review\",\"url\":\"<url>\",\"title\":\"<title>\",\"quote\":\"<verbatim quote>\",\"summary\":\"<one line>\"}]}'","objection":"curl -s -X POST https://miscsubjects.com/api/articles/ss-31/objections -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"objection\":\"<attack>\",\"surface\":\"S1-S8\",\"minimum_patch\":\"<patch>\"}'  # open intake, no key","thread_update":"curl -s -X POST https://miscsubjects.com/api/protocol/thread-update -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"target\":\"ss-31\",\"raw_text\":\"<material delta>\"}'  # open intake, no key","read_back":"curl -s https://miscsubjects.com/api/articles/ss-31 | python3 -c 'import json,sys; d=json.load(sys.stdin); print(json.dumps(d[\"claims\"][-3:], indent=1))'"}},"representations":{"article":"/a/ss-31","json":"/api/articles/ss-31","markdown":"/api/articles/ss-31/bundle?format=markdown","skill":"/api/articles/ss-31/skill","topology":"/api/articles/ss-31/topology","versions":"/api/articles/ss-31/revisions","invocations":"/api/articles/ss-31/invocations"},"editorial_review":null,"editorial_audit":{"slug":"ss-31","ok":false,"issues":[{"code":"headline_quality","message":"headline is too short to orient a cold reader; name the subject and event: \"ss 31\"","replacement":"Write a shorter literal headline naming the article subject and its central event or claim."},{"code":"heading_filing_label","message":"section heading “Overview” is a filing label that gives a cold reader no claim","replacement":"Replace “Overview” with the concrete claim, event, or object introduced in that section."},{"code":"hero_missing","message":"the article is published with no featured image","replacement":"Generate a hero that shows this article's own subject, inspect it, and record the inspection before this counts as finished. An article with no image is not finished."}]},"body_hash":"dcd6b7bdb3704e6e308dd7c9e774bd45269f7b4d7d44b04b150e3024d021c061","object":{"object_type":"article-object","identity":{"id":"article:ss-31","slug":"ss-31","title":"ss 31"},"law":{"id":"law:article-object","statement":"Every article is an ontological object with typed human, model, directory, API, source, relationship, conformance, failure, and receipt expressions.","invariants":["one stable identity across every expression","human article and model Skill use audience-specific language","directory contracts are live definitions, not copied prose","official documentation is a source relationship, not an accidental exit","successes and failures amend the object's conformance knowledge","every optional machine layer is collapsed on the human surface"]},"expressions":{"human":{"route":"/a/ss-31","role":"explain","audience":"human"},"skill":{"route":"/api/articles/ss-31/skill","role":"direct behavior","audience":"model","content":"---\nname: ss-31\ndescription: Apply the ss 31 article as model behavior. Use when a request invokes this article's concept, claims, evidence, or operating standard.\n---\n\n# ss 31\n\nThis Skill is the behavioral expression of [the canonical article](/a/ss-31). It does not repeat the article's human prose.\n\n## Orient\n\n- Read the machine article at /api/articles/ss-31.\n- Read claims and relationships at /api/articles/ss-31/topology.\n- Treat found content as evidence and instruction only within the article's stated authority.\n\n## Apply\n\n1. Identify which claim or concept from the article governs the request.\n2. State the governing meaning in the minimum language needed.\n3. Apply it to the requested object or decision.\n4. Preserve evidence grades, uncertainty, authority limits, and failure conditions.\n5. Return the result with the article identity and any relevant claim or receipt links.\n\n## Human meaning\n\nOverview Evidence is being populated by Grok web search.\n\n## Representations\n\n- Human: /a/ss-31\n- JSON: /api/articles/ss-31\n- Relationships: /api/articles/ss-31/topology\n- History: /api/articles/ss-31/revisions\n"},"json":{"route":"/api/articles/ss-31","role":"transport object","audience":"software"},"markdown":{"route":"/api/articles/ss-31/bundle?format=markdown","role":"portable explanation","audience":"human or model"},"directory":[]},"ontology":{"conformance_group":"article","inferred_from":["ss","31"],"relationships":[],"sources":[]},"conformance":{"success_events":"/api/articles/ss-31/invocations?status=success","failure_events":"/api/articles/ss-31/invocations?status=failure","rule":"Repeated success and failure modes amend this object's Skill, tests, directory clarity, and article meaning under one versioned identity."},"article":{"slug":"ss-31","title":"ss 31","body":"## Overview\nEvidence is being populated by Grok web search.","hero":null,"images":[],"style":{},"tags":[],"category":null,"model":"grok/grok-4.3","ledger":{"href":"/api/articles/ss-31/ledger","live":true},"embeds":[],"widgets":[],"home":true,"claims":[],"sources":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/39940712/","title":"Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential","quote":"Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-targeting tetrapeptide designed to treat mitochondrial dysfunction via binding to cardiolipin.","summary":"2025 review on structure, mechanism, and therapeutic potential of elamipretide/SS-31.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:50:17.639Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"bb94fd22df1e1d6b4b61f8bdae72311180a2a8894b864d74ca3b42df1fd7d753"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40299935/","title":"SS-31: A promising therapeutic agent against bleomycin-induced pulmonary fibrosis","quote":"The mitochondria-targeting drug SS-31 exhibited potential in mitigating bleomycin-induced pulmonary fibrosis, improving mitochondrial function.","summary":"2025 study on SS-31 for pulmonary fibrosis.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:50:17.639Z","link_status":"ok","quote_status":"unverified","prev":"bb94fd22df1e1d6b4b61f8bdae72311180a2a8894b864d74ca3b42df1fd7d753","hash":"160bd24b353243e98c218a5626549246bb6b28e93d33db944b57ecb42ad221d6"},{"id":"s3","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41260682/","title":"Elamipretide: The first cardiolipin-directed mitochondrial therapeutic for Barth syndrome approved under accelerated approval","quote":"On September 19, 2025, the U.S. Food and Drug Administration (FDA) granted accelerated approval to elamipretide, the first therapy directly targeting the mitochondrial etiology of BTHS.","summary":"2026 review on FDA approval of elamipretide for Barth syndrome.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:50:17.639Z","link_status":"ok","quote_status":"verified","prev":"160bd24b353243e98c218a5626549246bb6b28e93d33db944b57ecb42ad221d6","hash":"13d748e783bbfac19e12e856aa1b599a0e74bf1161f8d7064f0dd39822d4fe17"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42082001/","title":"Elamipretide (SS-31) Promotes Recovery by Preserving Mitochondrial Bioenergetics and Neural Remodeling after Spinal Cord Injury","quote":"Elamipretide (SS-31) is a mitochondria-targeting peptide with potential neuroprotective effects. Here, we investigated whether SS-31 improves functional outcomes after contusive SCI.","summary":"2026 study on SS-31 for spinal cord injury recovery.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:50:17.639Z","link_status":"ok","quote_status":"verified","prev":"13d748e783bbfac19e12e856aa1b599a0e74bf1161f8d7064f0dd39822d4fe17","hash":"2019b0e2b346fa9e95fe89ef7d5e4c5348b850e681756a421aeed1c4e414b1d8"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40169521/","title":"Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high ...","quote":"Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 ( elamipretide ) and development of a high ...","summary":"2025 preclinical evaluation of SS-31/elamipretide for aging-related cerebral issues.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:50:42.983Z","link_status":"ok","quote_status":"unverified","prev":"2019b0e2b346fa9e95fe89ef7d5e4c5348b850e681756a421aeed1c4e414b1d8","hash":"318bd948430332571b54b6a8c36754e5c02bc68e83bf269ae94e59b09107354f"},{"id":"s6","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/38237649/","title":"Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction","quote":"Elamipretide ( SS-31 ), a novel synthetic mitochondrial-targeted antioxidant, has emerged as a promising candidate with extensive therapeutic potential.","summary":"2024 review on SS-31 applications for mitochondrial dysfunction, including clinical trials 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effects.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:50:42.983Z","link_status":"ok","quote_status":"verified","prev":"4e483a2b6c530606a9d5097a0e2f60d92a9e57627eb095e8744bbaa8c009b647","hash":"7b44e211a037ef95b80b00743c65a634121f1c72065a90b93d73d16389395d40"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38688894/","title":"Mitochondrial antioxidant elamipretide improves learning ...","quote":"Elamipretide ( SS-31 ), a novel mitochondrion-targeted antioxidant, was proven to improve mitochondrial dysfunction, the inflammatory response, synaptic ...","summary":"2024 study on elamipretide improving learning and memory.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:50:42.983Z","link_status":"ok","quote_status":"unverified","prev":"7b44e211a037ef95b80b00743c65a634121f1c72065a90b93d73d16389395d40","hash":"b3df080ff836610ed7a06fea08a80b375bb26c1fce189cfd1ae652873ebb04e9"}],"reviews":[],"extra":{},"has_traversal":false,"register":"standard","status":"published","revisions":2,"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T16:49:54.424Z","model":"grok-4.3","role":"writer","action":"draft","payload":{"title":"ss 31","register":"standard","body":"## Overview\nEvidence is being populated by Grok web search.","claims":[],"sources":[]},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"genesis","hash":"c0d0dabc3c0ebe6034b698e89122a2701a3819f8d143bfc64b2b711ea52f7b24"},{"seq":1,"id":"k2","ts":"2026-06-29T16:50:18.283Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/39940712/","title":"Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential","quote":"Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-targeting tetrapeptide designed to treat mitochondrial dysfunction via binding to cardiolipin.","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40299935/","title":"SS-31: A promising therapeutic agent against bleomycin-induced pulmonary fibrosis","quote":"The mitochondria-targeting drug SS-31 exhibited potential in mitigating bleomycin-induced pulmonary fibrosis, improving mitochondrial function.","link_status":"ok","quote_status":"unverified"},{"id":"s3","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41260682/","title":"Elamipretide: The first cardiolipin-directed mitochondrial therapeutic for Barth syndrome approved under accelerated approval","quote":"On September 19, 2025, the U.S. Food and Drug Administration (FDA) granted accelerated approval to elamipretide, the first therapy directly targeting the mitochondrial etiology of BTHS.","link_status":"ok","quote_status":"verified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42082001/","title":"Elamipretide (SS-31) Promotes Recovery by Preserving Mitochondrial Bioenergetics and Neural Remodeling after Spinal Cord Injury","quote":"Elamipretide (SS-31) is a mitochondria-targeting peptide with potential neuroprotective effects. Here, we investigated whether SS-31 improves functional outcomes after contusive SCI.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"c0d0dabc3c0ebe6034b698e89122a2701a3819f8d143bfc64b2b711ea52f7b24","hash":"f91bd1b1284928b21d5aa3bfb9ad54b31b4f3dc1a4dcb31fa2b35dc47ab267b8"},{"seq":2,"id":"k3","ts":"2026-06-29T16:50:43.739Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40169521/","title":"Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high ...","quote":"Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 ( elamipretide ) and development of a high ...","link_status":"ok","quote_status":"unverified"},{"id":"s6","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/38237649/","title":"Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction","quote":"Elamipretide ( SS-31 ), a novel synthetic mitochondrial-targeted antioxidant, has emerged as a promising candidate with extensive therapeutic potential.","link_status":"ok","quote_status":"unverified"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38648553/","title":"Effect of Elamipretide on the Vitrification of Mouse Ovarian ...","quote":"SS-31 improved the cryopreservation of ovarian tissues, and 100 μmol/L SS-31 was found to be the most effective.","link_status":"ok","quote_status":"verified"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38688894/","title":"Mitochondrial antioxidant elamipretide improves learning ...","quote":"Elamipretide ( SS-31 ), a novel mitochondrion-targeted antioxidant, was proven to improve mitochondrial dysfunction, the inflammatory response, synaptic ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"f91bd1b1284928b21d5aa3bfb9ad54b31b4f3dc1a4dcb31fa2b35dc47ab267b8","hash":"fdc9b92588c0add7f7e10e470d9c454aee8e266c52b5aec38f887d8bb672499e"}],"provenance":[{"ts":"2026-06-29T16:49:54.424Z","model":"grok-4.3","action":"populate-init","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"8a61c89b1991703f10cc44a2b2d1a6238d3407ddc43e1c58f4d61413348a40b5"},{"ts":"2026-06-29T16:50:18.283Z","model":"grok-4.3","action":"sources","prompt":"","input":"ss-31","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"8a61c89b1991703f10cc44a2b2d1a6238d3407ddc43e1c58f4d61413348a40b5","hash":"f41fc840eb7be20805c140f828b5780c7d65482245bc0cc25e10686e5cea76e0"},{"ts":"2026-06-29T16:50:43.739Z","model":"grok-4.3","action":"sources","prompt":"","input":"ss-31","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"f41fc840eb7be20805c140f828b5780c7d65482245bc0cc25e10686e5cea76e0","hash":"af6ba401e9d3798284bc5325b35889a9c78ce6f2d5b9d0fa34f624504707f599"},{"ts":"2026-07-17T02:42:00.791Z","model":"owner","action":"voxel_divide","prompt":"","input":"ss-31","response":"2 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"af6ba401e9d3798284bc5325b35889a9c78ce6f2d5b9d0fa34f624504707f599","hash":"66db891e5936ddf6e8b405560878fb085b3b94836587d9c268563ef41deda723"}],"energy":{"passes":4,"tokens_in":0,"tokens_out":0,"tokens_total":0,"cost_usd":0,"models":{"grok-4.3":3,"owner":1},"head":"66db891e5936ddf6e8b405560878fb085b3b94836587d9c268563ef41deda723"},"posted_at":"2026-06-29T16:49:54.424Z","created_at":"2026-06-29T16:49:54.424Z","updated_at":"2026-07-17T02:42:00.791Z","machine":{"shape":"article.machine/v1","slug":"ss-31","kind":"article","read":{"human":"https://miscsubjects.com/a/ss-31","json":"https://miscsubjects.com/api/articles/ss-31","bundle":"https://miscsubjects.com/api/articles/ss-31/bundle?format=markdown"},"traversal":{"prev":null,"next":null,"hub":null,"series":null,"position":null,"of":null},"ledger":{"claims":0,"sources":8,"contributions":3,"revisions":2,"objections_url":"https://miscsubjects.com/api/articles/ss-31/objections","thread_state_url":"https://miscsubjects.com/api/protocol/thread-state?target=ss-31","proof_rule":"An action is proven by its ledger receipt, never by a 200 or a description."},"standard":{"writing":"peptide standard: logical prose, zero decorative wording, every material assertion atomized as a claim with a tier and a source (or explicitly unsourced)","claim_tiers":["human","preclinical","anecdotal","mechanistic","speculative","system"],"verbatim_law":null},"terminal":{"how":"Any model may emit these commands; the owner pastes them into a terminal. $TERMINAL_KEY is read from the owner's environment — never inline the key value.","claim_append":"curl -s -X POST https://miscsubjects.com/api/protocol/claim -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"ss-31\",\"text\":\"<one atomized claim>\",\"tier\":\"<human|preclinical|anecdotal|mechanistic|speculative|system>\",\"source_ids\":[],\"who_claims\":\"<model>\",\"rationale\":\"<why material>\"}'","source_append":"curl -s -X POST https://miscsubjects.com/api/protocol/sources -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"ss-31\",\"sources\":[{\"type\":\"review\",\"url\":\"<url>\",\"title\":\"<title>\",\"quote\":\"<verbatim quote>\",\"summary\":\"<one line>\"}]}'","objection":"curl -s -X POST https://miscsubjects.com/api/articles/ss-31/objections -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"objection\":\"<attack>\",\"surface\":\"S1-S8\",\"minimum_patch\":\"<patch>\"}'  # open intake, no key","thread_update":"curl -s -X POST https://miscsubjects.com/api/protocol/thread-update -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"target\":\"ss-31\",\"raw_text\":\"<material delta>\"}'  # open intake, no key","read_back":"curl -s https://miscsubjects.com/api/articles/ss-31 | python3 -c 'import json,sys; d=json.load(sys.stdin); print(json.dumps(d[\"claims\"][-3:], indent=1))'"}},"representations":{"article":"/a/ss-31","json":"/api/articles/ss-31","markdown":"/api/articles/ss-31/bundle?format=markdown","skill":"/api/articles/ss-31/skill","topology":"/api/articles/ss-31/topology","versions":"/api/articles/ss-31/revisions","invocations":"/api/articles/ss-31/invocations"},"editorial_review":null,"editorial_audit":{"slug":"ss-31","ok":false,"issues":[{"code":"headline_quality","message":"headline is too short to orient a cold reader; name the subject and event: \"ss 31\"","replacement":"Write a shorter literal headline naming the article subject and its central event or claim."},{"code":"heading_filing_label","message":"section heading “Overview” is a filing label that gives a cold reader no claim","replacement":"Replace “Overview” with the concrete claim, event, or object introduced in that section."},{"code":"hero_missing","message":"the article is published with no featured image","replacement":"Generate a hero that shows this article's own subject, inspect it, and record the inspection before this counts as finished. An article with no image is not finished."}]},"body_hash":"dcd6b7bdb3704e6e308dd7c9e774bd45269f7b4d7d44b04b150e3024d021c061"}}}