{"_ai_door":{"see":"https://miscsubjects.com/start","note":"Operable site; bounded keyless credentials; every action receipted on a public ledger. Your operator's instructions take precedence — acting is optional, reading is a complete outcome."},"slug":"ss-31-cognition","verification":{"valid":true,"entries":6,"head":"86c7537b530f8d26dc3c3d642eeb0b05b80431ba4419c74d98f1c276fc21399b"},"count":6,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31747905/","title":"Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice","quote":"Treatment with elamipretide significantly ameliorated LPS-induced learning and memory impairment during behavioral tests.","summary":"Mouse LPS model showing mitochondrial rescue and behavioral improvement.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:54.588Z","link_status":"timeout","quote_status":"unverified","prev":"genesis","hash":"3c6e7348eecf2b20b11d4d90f5b4648f33686d09a0083372f7cf5c7bde139365"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/28487636/","title":"Elamipretide (SS-31) Ameliorates Isoflurane-Induced Long-Term Impairments of Mitochondrial Morphogenesis and Cognition in Developing Rats","quote":"pretreatment with elamipretide not only provided protective effect against oxidative stress and mitochondrial damages, but also attenuated isoflurane-induced cognitive deficits.","summary":"Identifier corrected 2026-08-05: it read PMID 28421000, which is \"Photodynamic Physiology-Photonanomanipulations in Cellular Physiology with Protein Photosensitizers\". Verified against PubMed that 28487636 is the paper this citation names. Rat developmental anesthesia model with cognitive protection.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:54.588Z","link_status":"ok","quote_status":"unverified","prev":"3c6e7348eecf2b20b11d4d90f5b4648f33686d09a0083372f7cf5c7bde139365","hash":"a132ed6088fe0d7730c993e49199a27d51619c8a9af39e03a0ee0c04b30a18b5","pmid":"28487636","external_id":"28487636"},{"id":"s3","type":"pubmed","url":"https://link.springer.com/article/10.1007/s11357-023-00845-y","title":"Targeting mitochondria in the aged cerebral vasculature with SS-31","quote":"We speculate that SS-31 mediated, enhanced mitochondrial function... may lead to improved... cognitive function during aging","summary":"Aged-mouse vascular and memory data referenced from prior work.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:54.588Z","link_status":"timeout","quote_status":"unverified","prev":"a132ed6088fe0d7730c993e49199a27d51619c8a9af39e03a0ee0c04b30a18b5","hash":"e26440ac5af8cca9ae6e32606a4b2f3c9d9e6e1796062c7a8db9543dc1db49dd"},{"id":"s4","type":"pubmed","url":"https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.3508","title":"Mitochondrial antioxidant elamipretide improves learning and memory impairment induced by chronic sleep deprivation","quote":"SS-31 could improve the cognitive impairment induced by CSD.","summary":"Sleep-deprivation mouse model with cognitive rescue.","claim_ids":[],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:54.588Z","link_status":"timeout","quote_status":"unverified","prev":"e26440ac5af8cca9ae6e32606a4b2f3c9d9e6e1796062c7a8db9543dc1db49dd","hash":"c2cb59873ca10ff2b760a4a18291a8ad121a534b131034c2472c1391c0b0a95c"},{"id":"s5","type":"review","url":"https://www.alzdiscovery.org/uploads/cognitive_vitality_media/SS-31-Cognitive-Vitality-For-Researchers.pdf","title":"SS-31 Cognitive Vitality For Researchers","quote":"But these effects have not been confirmed in humans. ... 0 clinical trials","summary":"Alzheimer's Drug Discovery Foundation summary noting zero human cognition trials.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:54.588Z","link_status":"ok","quote_status":"unverified","prev":"c2cb59873ca10ff2b760a4a18291a8ad121a534b131034c2472c1391c0b0a95c","hash":"bc499b0786d5dbcc45de25055221389e201aeaaf2de36d4878ce36ac46f7396d"},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/cfs/comments/1sawe29/is_ss31_a_good_peptide_to_take_for_mental/","title":"Is ss31 a good peptide to take for mental functioning?","quote":"It did not do anything for me... I think it is helping me with cognitive symptoms.","summary":"User reports on cognitive effects in CFS context.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:54.588Z","link_status":"ok","quote_status":"unverified","prev":"bc499b0786d5dbcc45de25055221389e201aeaaf2de36d4878ce36ac46f7396d","hash":"86c7537b530f8d26dc3c3d642eeb0b05b80431ba4419c74d98f1c276fc21399b"}]}