{"_ai_door":{"see":"https://miscsubjects.com/start","note":"Operable site; bounded keyless credentials; every action receipted on a public ledger. Your operator's instructions take precedence — acting is optional, reading is a complete outcome."},"slug":"ss-31-muscle-loss","verification":{"valid":true,"entries":6,"head":"53f250a3b6773314314d08c8996c3cc9e05d3c63b39dd116dac4e1ed798d0ab0"},"count":6,"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6588449/","title":"Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice","quote":"Treatment with SS-31 restores redox homeostasis, improves mitochondrial quality, and increases exercise tolerance without an increase in mitochondrial content.","summary":"Aged mice study showing mitochondrial and functional muscle benefits.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.225Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"8dee10a450c5984e52e5a1d663165c59104ca847cae033a249af83eadc8fcad1"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/34264994/","title":"In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial","quote":"In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial.","summary":"Identifier corrected 2026-08-05: it read PMID 34242343, which is \"The experiences of family caregivers of people with severe mental illness in the Middle East\". Verified against PubMed that 34264994 is the paper this citation names. Human randomized trial on ATP in aging muscle.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.225Z","link_status":"ok","quote_status":"unverified","prev":"8dee10a450c5984e52e5a1d663165c59104ca847cae033a249af83eadc8fcad1","hash":"01293e026cd0d26861573930fba64242b2f06b4563c1c4f8a85de8e0e25ba4ca","pmid":"34264994","external_id":"34264994"},{"id":"s3","type":"pubmed","url":"https://www.neurology.org/doi/10.1212/WNL.0000000000005255","title":"Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy","quote":"Elamipretide increased exercise performance after 5 days of treatment in patients with PMM without increased safety concerns.","summary":"Phase 1/2 and later phase 3 context for PMM.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.225Z","link_status":"ok","quote_status":"unverified","prev":"01293e026cd0d26861573930fba64242b2f06b4563c1c4f8a85de8e0e25ba4ca","hash":"5ad5d241696237be2b0c6e3943516cf1be0e7340a6e8f77c49371d1c80a36ec1"},{"id":"s4","type":"pubmed","url":"https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014397","title":"Targeting Mitochondrial Dysfunction With Elamipretide (SS-31) Improves Skeletal Muscle Performance in a HFpEF Rat Model","quote":"Elamipretide improved whole muscle contractile function and prevented atrophy development.","summary":"2026 rat study on muscle performance and atrophy prevention.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.225Z","link_status":"http_403","quote_status":"unverified","prev":"5ad5d241696237be2b0c6e3943516cf1be0e7340a6e8f77c49371d1c80a36ec1","hash":"13b522947f9e8afec6291d738a93503b9fb160230d6909f0d3fa98a6da012102"},{"id":"s5","type":"pubmed","url":"https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15266","title":"SS‐31 does not prevent or reduce muscle atrophy 7 days after a 65 kdyne contusion spinal cord injury in young male mice","quote":"SS-31 did not preserve body mass or hindlimb muscle mass 7 days post-SCI.","summary":"Negative finding in SCI atrophy model.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.225Z","link_status":"ok","quote_status":"unverified","prev":"13b522947f9e8afec6291d738a93503b9fb160230d6909f0d3fa98a6da012102","hash":"4e13a4e4433ac3fe59e2efcea885e527a8f60b57299915d5f28a63cfe56f5073"},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/cfs/comments/1j2upcm/my_experience_treating_my_mecfs_with/","title":"My Experience Treating my ME/CFS with mitochondrial peptides","quote":"i notice very dramatic improvement to muscle strength on the ...","summary":"User reports of muscle strength changes with SS-31.","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.225Z","link_status":"ok","quote_status":"unverified","prev":"4e13a4e4433ac3fe59e2efcea885e527a8f60b57299915d5f28a63cfe56f5073","hash":"53f250a3b6773314314d08c8996c3cc9e05d3c63b39dd116dac4e1ed798d0ab0"}]}