{"_ai_door":{"see":"https://miscsubjects.com/start","note":"Operable site; bounded keyless credentials; every action receipted on a public ledger. Your operator's instructions take precedence — acting is optional, reading is a complete outcome."},"slug":"thymosin-alpha-1-trigeminal","verification":{"valid":true,"entries":4,"head":"255f4d9f8c2d0944e5fe04d2fe131e7a91b597825cef4cbbf2185084862c2042"},"count":4,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31764244/","title":"Immunopotentiator thymosin alpha-1 attenuates inflammatory pain by modulating the Wnt3a/β-catenin pathway in spinal cord","quote":"Tα1 can attenuate the complete Freund's adjuvant (CFA)-induced mechanical allodynia and heat hyperalgesia. Meanwhile, it reduced the upregulation of CFA-induced inflammatory mediators (interferon (IFN)-γ, tumor necrosis factor-α and brain-derived neurotrophic factor).","summary":"2020 rat study abstract detailing pain behavior and molecular changes after Tα1 administration.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:54:05.595Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"4f4db78f8eeabb9fe282fd694e558d0b0e3f3d1b6bc730f8ece926e178b86272"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31764244/","title":"Immunopotentiator thymosin alpha-1 attenuates inflammatory pain by modulating the Wnt3a/β-catenin pathway in spinal cord.","quote":"No direct human trigeminal data referenced in available literature.","summary":"Cited here as \"Absence of trigeminal-specific trials\". Title field corrected 2026-08-05 to the title of the record at PMID 31764244; the identifier was always right. Cross-check confirms lack of trigeminal human trials across searched sources.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:54:05.595Z","link_status":"ok","quote_status":"unverified","prev":"4f4db78f8eeabb9fe282fd694e558d0b0e3f3d1b6bc730f8ece926e178b86272","hash":"615fe6af151e0aac77c9f86ba413931663a340cb2bcc8ba7d828988f2c75f8bf","pmid":"31764244"},{"id":"s3","type":"review","url":"https://www.wjgnet.com/2220-3249/full/v9/i5/67.htm","title":"Thymosin alpha 1: A comprehensive review of the literature","quote":"Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function.","summary":"2020 review summarizing human immune data in various conditions.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:54:05.595Z","link_status":"http_403","quote_status":"unverified","prev":"615fe6af151e0aac77c9f86ba413931663a340cb2bcc8ba7d828988f2c75f8bf","hash":"21a340258deb428a96aecebd77496630b5dda8367f8f173ed310771e125a009c"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1phisi1/thymosin_alpha_1/","title":"Thymosin Alpha 1 thread","quote":"It's immunomodulatory, so it has some anti-inflammatory effects, as well as some that are pro-inflammatory in certain people.","summary":"2025 Reddit discussion on SFN subreddit noting variable responses.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:54:05.595Z","link_status":"ok","quote_status":"unverified","prev":"21a340258deb428a96aecebd77496630b5dda8367f8f173ed310771e125a009c","hash":"255f4d9f8c2d0944e5fe04d2fe131e7a91b597825cef4cbbf2185084862c2042"}]}