{"_ai_door":{"see":"https://miscsubjects.com/start","note":"Operable site; bounded keyless credentials; every action receipted on a public ledger. Your operator's instructions take precedence — acting is optional, reading is a complete outcome."},"slug":"thymosin-alpha-1","verification":{"valid":true,"entries":107,"head":"deb365464c96fee874d992420897cdaa36dbb674fb9cb908298ad6061e186ff7"},"count":107,"sources":[{"id":"s1","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/","title":"Thymosin alpha 1: A comprehensive review of the literature","quote":"Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function.","summary":"2020 review covering background, mechanisms, and clinical uses in immune contexts.","claim_ids":["c1","c2","c3","c4","c61"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:34:27.728Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"c8865aacafa144a2f67170c723701cb4a77bda313934858527b1017c76a7e6d7","source_role":"mechanism_support"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/27450734/","title":"Immune Modulation with Thymosin Alpha 1 Treatment","quote":"Thymosin alpha 1 (Ta1) is a peptide originally isolated from thymic tissue as the compound responsible for restoring immune function to thymectomized mice.","summary":"2016 review on preclinical and clinical immune modulation.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:34:27.728Z","link_status":"ok","quote_status":"verified","prev":"c8865aacafa144a2f67170c723701cb4a77bda313934858527b1017c76a7e6d7","hash":"3a2c49cdbadc8c73b2aa5932c1671e7661c89fa1910ab017c66d56af98bdbbdb","source_role":"mechanism_support"},{"id":"s3","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/38308608/","title":"Comprehensive Review of the Safety and Efficacy of Thymosin Alpha 1 in Human Clinical Trials","quote":"This study aims to assess the safety and efficacy of Thymosin Alpha 1 (Tα1) through a comprehensive narrative review of clinical studies involving over 11 000 human subjects in more than 30 trials.","summary":"2024 review of human trials and safety.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:34:27.728Z","link_status":"ok","quote_status":"verified","prev":"3a2c49cdbadc8c73b2aa5932c1671e7661c89fa1910ab017c66d56af98bdbbdb","hash":"62e0108ba1db6835b71fca9afb198b2f63ea2cd29c89f43b79b986aa5b20e9b3","source_role":"mechanism_support"},{"id":"s4","type":"clinical_trial","url":"https://www.bmj.com/content/388/bmj-2024-082583","title":"The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial","quote":"This trial found no clear evidence to suggest that thymosin α1 decreases 28 day all cause mortality in adults with sepsis.","summary":"Large 2025 phase 3 RCT (n=1106) showing no significant mortality benefit of thymosin α1 in sepsis patients.","author":"","publisher":"","date":"","claim_ids":["c10"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:12.760Z","link_status":"http_403","quote_status":"unverified","prev":"62e0108ba1db6835b71fca9afb198b2f63ea2cd29c89f43b79b986aa5b20e9b3","hash":"1370e624ff7f434258d00b61dd61709182caf5dea0547dffa7862c403de14a20","source_role":"adjacent_context"},{"id":"s5","type":"review","url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1388959/full","title":"Phenotypic drug discovery: a case for thymosin alpha-1","quote":"This article explores the experiences of researchers testing the effect of a thymic peptide hormone, thymosin alpha-1, in preclinical and clinical settings.","summary":"2024 review framing thymosin alpha-1 as example of phenotypic drug discovery with broad immunomodulatory applications.","author":"","publisher":"","date":"","claim_ids":["c11"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:12.760Z","link_status":"ok","quote_status":"unverified","prev":"1370e624ff7f434258d00b61dd61709182caf5dea0547dffa7862c403de14a20","hash":"938ad57612eecfe66f1cdeefc1e303c64743e3153bc5f0a1a289e84fc6219e3b","source_role":"mechanism_support"},{"id":"s6","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT06821100","title":"Thymalfasin (Thymosin Alpha 1; 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This peptide brings me back to life.","summary":"User anecdote reporting significant improvement in long COVID symptoms after starting TA-1 peptide.","author":"","publisher":"","date":"","claim_ids":["c14","c62"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:12.760Z","link_status":"ok","quote_status":"unverified","prev":"d5b3bd78fd9f4c74891acae0d44d845668807bb82e1949925f008992c0a048cd","hash":"3e5ab07568cb6fa3568b27587a971d9eec905f68a22fccbeae05606449554955","source_role":"anecdotal_report"},{"id":"s9","type":"review","url":"https://www.mdpi.com/1422-0067/26/23/11470","title":"Aging and Thymosin Alpha-1","quote":"Preclinical and clinical studies show that Tα1 can improve vaccine response in the elderly and mitigate immunosenescence.","summary":"2025 review on thymosin alpha-1 for aging-related immune decline and vaccine enhancement.","author":"","publisher":"","date":"","claim_ids":["c15"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:12.760Z","link_status":"http_403","quote_status":"unverified","prev":"3e5ab07568cb6fa3568b27587a971d9eec905f68a22fccbeae05606449554955","hash":"90d4f5cda865c21ed4a30938ec962a87c01d2d97de52f25dae23c371d8fd1de7","source_role":"mechanism_support"},{"id":"s10","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT07644897","title":"Thymosin Alpha 1 Combined With Anti-PD-1 Monoclonal Antibody in Elderly Patients With Advanced Melanoma","quote":"Primary Objective: To evaluate the effectiveness of Thymosin Alpha-1 combined with PD-1 monoclonal antibody in elderly patients with advanced melanoma .","summary":"New 2026 clinical trial testing thymosin alpha 1 combined with anti-PD-1 for advanced melanoma in elderly patients.","author":"","publisher":"","date":"","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:41.437Z","link_status":"ok","quote_status":"unverified","prev":"90d4f5cda865c21ed4a30938ec962a87c01d2d97de52f25dae23c371d8fd1de7","hash":"e5e1e222ffd54fd30995422fd6ba404746b3a9427f5b286bf9685bbc949579c4","source_role":"adjacent_context"},{"id":"s11","type":"review","url":"https://www.innerbody.com/thymosin-alpha-1-peptide","title":"Thymosin Alpha-1 Peptide: Benefits and Safety [2026]","quote":"In contrast to those findings, a placebo-controlled trial from early 2025 with over 1,000 subjects found “no clear evidence” that TA-1 decreased 28-day all-cause mortality in adults with sepsis.","summary":"2026 comprehensive article reviewing uses, safety, and recent 2025 sepsis trial results for thymosin alpha-1.","author":"","publisher":"","date":"","claim_ids":["c17"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:41.437Z","link_status":"ok","quote_status":"verified","prev":"e5e1e222ffd54fd30995422fd6ba404746b3a9427f5b286bf9685bbc949579c4","hash":"e8f5edcd020b445158365d0497fd41735fa13ad8af2fea625cf8c727d36158d4","source_role":"mechanism_support"},{"id":"s12","type":"youtube","url":"https://www.youtube.com/shorts/_3M2gu4kG68","title":"Autoimmune Peptides: Just Hype? (Thymosin Alpha-1 ...","quote":"Thymosin Alpha-1 helps recalibrate immune function so your body stops attacking itself while still defending against infections.","summary":"2026 YouTube short discussing thymosin alpha-1 for autoimmune conditions.","author":"","publisher":"","date":"","claim_ids":["c18"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:41.437Z","link_status":"ok","quote_status":"unverified","prev":"e8f5edcd020b445158365d0497fd41735fa13ad8af2fea625cf8c727d36158d4","hash":"782d884dc34110bda4abf8ff61402db53c5298779c92c3a7451370e7e289620c","source_role":"anecdotal_report"},{"id":"s13","type":"reddit","url":"https://www.reddit.com/r/cfs/comments/1nl65vu/be_careful_about_thymosin_alpha1/","title":"be careful about thymosin alpha-1 : r/cfs","quote":"I am having the same problems with TA-1 I just connected the dots after 2 weeks of being on TA-1 my lymph nodes are swollen in my neck ...","summary":"User reports swollen lymph nodes as a negative side effect after 2 weeks on TA-1.","author":"","publisher":"","date":"","claim_ids":["c19"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:59.705Z","link_status":"ok","quote_status":"unverified","prev":"782d884dc34110bda4abf8ff61402db53c5298779c92c3a7451370e7e289620c","hash":"196082d97ac04d7df970d50558f1720b5406e76a70d51c656becb81e5d913bfe","source_role":"anecdotal_report"},{"id":"s14","type":"reddit","url":"https://www.reddit.com/r/covidlonghaulers/comments/1pbotcz/anyone_get_side_effectsan_immune_reaction_to/","title":"Anyone get side effects/an immune reaction to Thymosin- ...","quote":"Im 2 weeks into TA-1 , its working as expected. Immune activation/rebalancing - clearing out virus/viral debris my body was unable to deal with before (Feels like a bad cold/minor flu).","summary":"User describes initial flu-like symptoms as part of positive immune activation, followed by overall improvement after waves.","author":"","publisher":"","date":"","claim_ids":["c20"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:59.705Z","link_status":"ok","quote_status":"unverified","prev":"196082d97ac04d7df970d50558f1720b5406e76a70d51c656becb81e5d913bfe","hash":"cb1cd196b18a80c106845108e087b7a3b8c9b32bd54cf1a12a0dead79a08e81e","source_role":"anecdotal_report"},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/Ameano_Peptides/comments/1ojbasq/a_complete_guide_for_thymosin_alpha_1/","title":"A Complete Guide for Thymosin Alpha 1","quote":"I have been experimenting with ta1 and vip for a few weeks for some really bad eczema and doing a similar protocol. my eczema seems to respond really well to ta1...","summary":"User reports good outcome with reduced eczema using TA-1.","author":"","publisher":"","date":"","claim_ids":["c21"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:59.705Z","link_status":"ok","quote_status":"unverified","prev":"cb1cd196b18a80c106845108e087b7a3b8c9b32bd54cf1a12a0dead79a08e81e","hash":"53ce60a83e3337a6b83726e1cc8b5a94aed82392960276d7bfb50e84d1263756","source_role":"anecdotal_report"},{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/covidlonghaulers/comments/1l2k4tj/thymosin_alpha1_t%CE%B11_has_anyone_seen_any_studies/","title":"Thymosin Alpha 1 (Tα1) has anyone seen any studies or ...","quote":"I just stated my ta-1 about two weeks ago and I can confirm I have felt the benefits majorly. Clearer head, heightened energy, just the ...","summary":"Positive user experience: clearer head and increased energy after 2 weeks on TA-1.","author":"","publisher":"","date":"","claim_ids":["c22"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:59.705Z","link_status":"ok","quote_status":"unverified","prev":"53ce60a83e3337a6b83726e1cc8b5a94aed82392960276d7bfb50e84d1263756","hash":"42fd462166db0170a0940b5b5bbce4c0b676331ab16aa38f30b4e4d4b1ab8cea","source_role":"anecdotal_report"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/MCAS/comments/1mcx0o3/peptide_called_thymosin_alpha_1_is_resolving_my/","title":"Peptide called Thymosin Alpha 1 is resolving my MCAS","quote":"TA-1 works when I use it! But it doesn't have a noticeable benefit when I'm not using it.","summary":"User reports TA-1 helps resolve MCAS symptoms while using it, with relapse when stopping; another user noted a flare.","author":"","publisher":"","date":"","claim_ids":["c23"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:59.705Z","link_status":"ok","quote_status":"unverified","prev":"42fd462166db0170a0940b5b5bbce4c0b676331ab16aa38f30b4e4d4b1ab8cea","hash":"2f6bfc90da8731e622e1e3c82498870e0f3adc1d18b6b51166c2e7d7ed88d373","source_role":"anecdotal_report"},{"id":"s18","type":"x","url":"https://x.com/BowTiedUM/status/1760474750730568092","title":"The Superhuman Immune System Peptide Big Pharma Wants BANNED","quote":"I knew I struck gold when I caught a cold, took a 2mg shot, and woke up the next day feeling GREAT. My cough, runny nose, and body aches: GONE","summary":"Personal anecdote of rapid recovery from cold symptoms after TA-1 injection.","author":"","publisher":"","date":"","claim_ids":["c24"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:59.705Z","link_status":"ok","quote_status":"unverified","prev":"2f6bfc90da8731e622e1e3c82498870e0f3adc1d18b6b51166c2e7d7ed88d373","hash":"988bbc26e9a8bee45daba8c10c694667f635b6fd9b2f970018a4b4a2a55d07d3","source_role":"anecdotal_report"},{"id":"s19","type":"x","url":"https://x.com/jessicaalanas/status/1755232184317649040","title":"Megadose experience with Thymosin Alpha 1","quote":"I took a megadose of Thymosin Alpha 1 peptide for 3 days in a row. By day 3, I was so sick I could not go outside. Today, I woke up and I feel significantly *stronger* than before.","summary":"User felt temporarily worse (sick) then stronger afterward, attributing to immune activation against stealth infections.","author":"","publisher":"","date":"","claim_ids":["c25"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:00:59.705Z","link_status":"ok","quote_status":"verified","prev":"988bbc26e9a8bee45daba8c10c694667f635b6fd9b2f970018a4b4a2a55d07d3","hash":"30ac172e3e3cb07ab02c345f054738f5baaa5db793384d81e84f747a2f89b543","source_role":"anecdotal_report"},{"id":"s20","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT04487444","title":"Thymalfasin (Thymosin Alpha 1) to Treat COVID-19 Infection","quote":"A course of Ta1 administered to hospitalized individuals with COVID-19 infection and lymphocytopenia will improve the time to recovery (primary objective) and ...","summary":"Ongoing or completed trial on Ta1 for COVID-19 recovery in lymphocytopenic patients.","author":"","publisher":"","date":"","claim_ids":["c26"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:01:20.752Z","link_status":"ok","quote_status":"unverified","prev":"30ac172e3e3cb07ab02c345f054738f5baaa5db793384d81e84f747a2f89b543","hash":"2d618dcafbb985e456b6c835438178dbf008c5db740bc76dc8b5c2dabac1074d","source_role":"adjacent_context"},{"id":"s21","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12208829/","title":"Thymosin alpha 1 alleviates inflammation and prevents infection in patients with severe acute pancreatitis through immune regulation: a systematic review and meta-analysis","quote":"Five randomized controlled trials comprising 706 patients with SAP were included.","summary":"2025 meta-analysis showing Ta1 reduces inflammation and infection in severe acute pancreatitis via immune regulation.","author":"","publisher":"","date":"","claim_ids":["c27"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:01:20.752Z","link_status":"ok","quote_status":"verified","prev":"2d618dcafbb985e456b6c835438178dbf008c5db740bc76dc8b5c2dabac1074d","hash":"3d3fc4e7fefbf325257788fd95bf85f5764d3c0a43d8b43d3ff799b5582139fa","source_role":"mechanism_support"},{"id":"s22","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40955371/","title":"The Immunomodulatory Activity of Thymosin Alpha 1 on Tumor Cell Lines and Distinct Immune Cell Subsets","quote":"The Immunomodulatory Activity of Thymosin Alpha 1 on Tumor Cell Lines and Distinct Immune Cell Subsets. Onco Targets Ther. 2025 Sep 10:18:995-1012.","summary":"2025 study on Ta1's immunomodulatory effects on cancer cells and immune subsets.","author":"","publisher":"","date":"","claim_ids":["c28"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:01:20.752Z","link_status":"ok","quote_status":"unverified","prev":"3d3fc4e7fefbf325257788fd95bf85f5764d3c0a43d8b43d3ff799b5582139fa","hash":"5d6f1e6fb3f1a0d095118761419d3384973f1fb9ba1625bb7c176ac5dbf2a11c","source_role":"mechanism_support"},{"id":"s23","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39867848/","title":"Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency","quote":"Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency.","summary":"2025 proof-of-concept on potential antidepressant effects of Ta1 in CVID patients.","author":"","publisher":"","date":"","claim_ids":["c29"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:01:20.752Z","link_status":"ok","quote_status":"unverified","prev":"5d6f1e6fb3f1a0d095118761419d3384973f1fb9ba1625bb7c176ac5dbf2a11c","hash":"276d491d3db1e0a68a56f2ce64e07f1b000dc36419c6007c3da47a4241b65aa5","source_role":"mechanism_support"},{"id":"s24","type":"reddit","url":"https://www.reddit.com/r/HairlossResearch/comments/1rgcn3a/peptide_for_alopecia_thymosin_alpha_1_as_an/","title":"Peptide for alopecia: Thymosin Alpha 1 as an Alternative to ...","quote":"TA1 is taken to suppress inflammation caused by the immune system. There is no clinical data that shows TA1 can heal your alopecia but it sounds promising.","summary":"Reddit discussion on using TA1 for alopecia via immune modulation.","author":"","publisher":"","date":"","claim_ids":["c30"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:01:20.752Z","link_status":"ok","quote_status":"unverified","prev":"276d491d3db1e0a68a56f2ce64e07f1b000dc36419c6007c3da47a4241b65aa5","hash":"9f6c54b2e2aecd0e76d3b3092918f94d75fe9e98cdba572aaae575fb0ad1a96f","source_role":"anecdotal_report"},{"id":"s25","type":"reddit","url":"https://www.reddit.com/r/Biohack_Blueprint/comments/1thd0od/thymosin_alpha1_complete_guide_the_immune_peptide/","title":"Thymosin Alpha-1 Complete Guide: The Immune Peptide ...","quote":"Thymosin Alpha-1 modulates immune function in multiple ways: T-cell maturation and function.","summary":"User guide and discussion on TA1 mechanisms and use.","author":"","publisher":"","date":"","claim_ids":["c31"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:01:20.752Z","link_status":"ok","quote_status":"unverified","prev":"9f6c54b2e2aecd0e76d3b3092918f94d75fe9e98cdba572aaae575fb0ad1a96f","hash":"b54f56b49f3228ec6669eac333a7d711dbc45637ef7dfde842bf4a5c3e1293c6","source_role":"anecdotal_report"},{"id":"s26","type":"x","url":"https://x.com/RickWingfield5/status/2071331718015918545","title":"X post on Thymosin Alpha 1","quote":"One \"immune peptides\" out there is Thymosin ALPHA 1. It is approved in over 40 countries.","summary":"Recent X post noting international approval of TA1 as immune peptide.","author":"","publisher":"","date":"","claim_ids":["c32"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:01:20.752Z","link_status":"ok","quote_status":"unverified","prev":"b54f56b49f3228ec6669eac333a7d711dbc45637ef7dfde842bf4a5c3e1293c6","hash":"6196a28f924807abca91901453613efd7306b096875d484b8d96410ae70f8147","source_role":"anecdotal_report"},{"id":"s27","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40969554/","title":"Efficacy of thymosin α1 for sepsis: a systematic review and meta-analysis of randomized controlled trials","quote":"Tα1 has the potential to decrease 28-day mortality rates in patients with sepsis; however, it is crucial to recognize that its efficacy differs among various subgroups. These observations underscore the significance of personalized immunotherapy strategies in forthcoming clinical trials.","summary":"2025 meta-analysis of 11 RCTs finds Tα1 associated with reduced 28-day sepsis mortality overall but no benefit in high-quality or multicenter subgroups; notes heterogeneity and need for more data.","author":"","publisher":"","date":"","claim_ids":["c33"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:02:22.999Z","link_status":"ok","quote_status":"verified","prev":"6196a28f924807abca91901453613efd7306b096875d484b8d96410ae70f8147","hash":"172517fd35a7a45e69faa54e7d29137526465340f0ec81146261870ca6efd966","source_role":"mechanism_support"},{"id":"s28","type":"medical","url":"https://superpower.com/guides/thymosin-alpha-1","title":"Thymosin Alpha-1 (Zadaxin): A Thymic Peptide and Toll-Like Receptor Signaling Modulator","quote":"Thymosin alpha-1 is a 28-amino-acid thymic peptide approved as Zadaxin in more than 35 countries for chronic hepatitis B but not FDA-approved in the US. ... As of April 2026, thymosin alpha-1 is not FDA-approved in the United States. It is approved internationally under the brand name Zadaxin for chronic hepatitis B in more than 35 countries, including China and Italy. In the US, it holds FDA 503A Category 2 status following the February 2026 reclassification.","summary":"April 2026 reviewed guide on TA-1 mechanisms, hepatitis B evidence, regulatory status (not FDA-approved, compounding available), and clinical data.","author":"","publisher":"","date":"","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:02:22.999Z","link_status":"ok","quote_status":"unverified","prev":"172517fd35a7a45e69faa54e7d29137526465340f0ec81146261870ca6efd966","hash":"44cd95302dedadb9c88af6acbf98e693d33d877b541606d0c7f69b570932b377","source_role":"adjacent_context"},{"id":"s29","type":"reddit","url":"https://www.reddit.com/r/ankylosingspondylitis/comments/1rzhnmd/thymosin_alpha_1_peptide/","title":"Thymosin alpha 1 peptide?","quote":"The peptide thymosin alpha 1 has been shown to be able retrain the immune system. Ankylosing is an autoimmune disorder. It helps heal the gut but also helps ... Ok I have tried this peptide.","summary":"2026 Reddit thread in r/ankylosingspondylitis discussing TA-1 for autoimmune conditions like ankylosing spondylitis; user reports trying it.","author":"","publisher":"","date":"","claim_ids":["c35"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:02:22.999Z","link_status":"ok","quote_status":"unverified","prev":"44cd95302dedadb9c88af6acbf98e693d33d877b541606d0c7f69b570932b377","hash":"59e34a8cd6e92fc0d1c69c79091f610ffeb6fd483d1cde7e9435f7aec685c746","source_role":"anecdotal_report"},{"id":"s30","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1sx69j7/thymosin_alpha1_guide_immune_support_dosing_and/","title":"Thymosin Alpha-1 guide immune support, dosing, and ...","quote":"Thymosin Alpha-1 guide immune support, dosing , It helps regulate immune response. Its been studied in hepatitis B and C","summary":"Reddit post providing guide on TA-1 for immune support, dosing, and mentions studies in hepatitis B and C.","author":"","publisher":"","date":"","claim_ids":["c36"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:02:22.999Z","link_status":"ok","quote_status":"unverified","prev":"59e34a8cd6e92fc0d1c69c79091f610ffeb6fd483d1cde7e9435f7aec685c746","hash":"b2208a8b3d3a2011a9f2cdc4956daf3f4f698122a51bc2a63d6dd6f27099e850","source_role":"anecdotal_report"},{"id":"s31","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41883056","title":"IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8+ T Cells and Enhances Antitumor Immunity in Hepatocellular Carcinoma","quote":"Combined IL-15 and Tα1 therapy reverses CD8 + T cell senescence and enhances antitumor immunity in HCC through suppression of the phosphatidylinositol ...","summary":"2026 study on IL-15 combined with thymosin α1 reducing senescent CD8+ T cells and boosting antitumor effects in HCC.","author":"","publisher":"","date":"","claim_ids":["c37"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:02:47.432Z","link_status":"ok","quote_status":"unverified","prev":"b2208a8b3d3a2011a9f2cdc4956daf3f4f698122a51bc2a63d6dd6f27099e850","hash":"331691eeaf0167b3fdcec6ddfb392cbf376610a499dd72eb78afd33aa7919d5a","source_role":"mechanism_support"},{"id":"s32","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12904209/","title":"Age-related thymic involution: Mechanistic insights and rejuvenating approaches to restore immune function","quote":"Thymosin α1 is used to treat some chronic viral infections , such as hepatitis B and C, as an immunomodulator (125). In a recent retrospective analysis of patients with COVID-19 treated with thymosin α, this hormone enhanced T cell production...","summary":"2026 review discusses thymosin α1 as immunomodulator for viral infections and its role in improving thymic function and T cell production in COVID-19 contexts.","author":"","publisher":"","date":"","claim_ids":["c38"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:02:47.432Z","link_status":"ok","quote_status":"unverified","prev":"331691eeaf0167b3fdcec6ddfb392cbf376610a499dd72eb78afd33aa7919d5a","hash":"9baa65ceb457b591d6cf5132ed8e5bbe9a74800cb54f654544c7ddf21bc18297","source_role":"mechanism_support"},{"id":"s33","type":"review","url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1571456/full","title":"Thymosin alpha 1 alleviates inflammation and prevents infection in patients with severe acute pancreatitis through immune regulation: a systematic review and meta-analysis","quote":"Five randomized controlled trials comprising 706 patients with SAP were included. The results indicated that Tα1 could increase the percentages of CD4 + cells (MD=4.53, 95%CI [3.02, 6.04], P<0.00001) and improve the CD4 + /CD8 + ratio...","summary":"2025 meta-analysis of 5 RCTs (706 SAP patients) showing Tα1 improves CD4+ cells, CD4/CD8 ratio, reduces CRP (low dose), and prevents extrapancreatic infections.","author":"","publisher":"","date":"","claim_ids":["c39"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:02:47.432Z","link_status":"ok","quote_status":"unverified","prev":"9baa65ceb457b591d6cf5132ed8e5bbe9a74800cb54f654544c7ddf21bc18297","hash":"4ef6beeaffd9d1fbfb343a3bf51250753b6dc84c8171114674dc9f38db7005a9","source_role":"mechanism_support"},{"id":"s34","type":"youtube","url":"https://www.youtube.com/watch?v=d_ZW05Wrm_s","title":"What Is Thymosin Alpha 1? How It Works and What the Clinical Data Shows","quote":"We cover: 🛡️ What Thymosin Alpha-1 is and how it regulates your immune system Why it's ideal for inflammation, immune burnout, and chronic ...","summary":"2026 YouTube video reviewing thymosin alpha 1 mechanism, clinical data, benefits for immune regulation and inflammation.","author":"","publisher":"","date":"","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:02:47.432Z","link_status":"http_429","quote_status":"unverified","prev":"4ef6beeaffd9d1fbfb343a3bf51250753b6dc84c8171114674dc9f38db7005a9","hash":"c11839fe5d2ccfb168bbfa7008fb3e31831bfc13ab5e9cbca75ef4c89a7e151f","source_role":"anecdotal_report"},{"id":"s35","type":"reddit","url":"https://www.reddit.com/r/LongCovidTrials/comments/1opyifn/has_anyone_tried_thymosin_alpha_1_for_long_covid/","title":"Has anyone tried Thymosin Alpha 1 for Long COVID?","quote":"Hi all, Our team is curious if anyone out there has tried the peptide Thymosin Alpha 1 for Long COVID. We’re asking for research purposes (not endorsing ...","summary":"2025 Reddit post in LongCovidTrials seeking anecdotal experiences with thymosin alpha 1 for long COVID.","author":"","publisher":"","date":"","claim_ids":["c41"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:02:47.432Z","link_status":"ok","quote_status":"unverified","prev":"c11839fe5d2ccfb168bbfa7008fb3e31831bfc13ab5e9cbca75ef4c89a7e151f","hash":"d0ac7e52f1109ca84229b3913906c62dbb4d581fb266e4a8d206b809a7c62260","source_role":"anecdotal_report"},{"id":"s36","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12692621/","title":"Aging and Thymosin Alpha-1","quote":"Thymosin alpha-1 (Tα1), a peptide hormone produced by the thymus, exhibits potent immunomodulatory, anti-inflammatory, and antioxidant properties.","summary":"2025 review on thymosin alpha-1's role in aging, immunomodulation, anti-inflammatory and antioxidant effects.","author":"","publisher":"","date":"","claim_ids":["c42"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:02:47.432Z","link_status":"ok","quote_status":"verified","prev":"d0ac7e52f1109ca84229b3913906c62dbb4d581fb266e4a8d206b809a7c62260","hash":"1b88ee0d44eb9b7294067d00ab67e744645d5129315c027931b77088146d0569","source_role":"mechanism_support"},{"id":"s37","type":"reddit","url":"https://www.reddit.com/r/CIRS/comments/1ncxx31/thymosinalpha_1/","title":"Thymosin-alpha 1 ??","quote":"I actually tried it back in October and it sent me into the worst flare I’ve had in 4 years. Felt awful and took me almost 2 full months to recover.","summary":"User reported severe negative reaction/flare after trying TA-1 while possibly exposed to mold; others report herxing initially but gradual improvement with slow titration, better energy, or immune balancing.","author":"","publisher":"","date":"","claim_ids":["c43"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:03:23.964Z","link_status":"ok","quote_status":"unverified","prev":"1b88ee0d44eb9b7294067d00ab67e744645d5129315c027931b77088146d0569","hash":"ca4a4ad545c23e812dac6fcc689a152ffa0a724e2297e6f996fdd18bda103712","source_role":"anecdotal_report"},{"id":"s38","type":"reddit","url":"https://www.reddit.com/r/Hashimotos/comments/1lped2z/peptides/","title":"Peptides","quote":"I tried TA-1 for 8 weeks and it increased my TPO antibodies.","summary":"Negative outcome: TA-1 increased thyroid antibodies in Hashimoto's patient after 8 weeks.","author":"","publisher":"","date":"","claim_ids":["c44"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:03:23.964Z","link_status":"ok","quote_status":"unverified","prev":"ca4a4ad545c23e812dac6fcc689a152ffa0a724e2297e6f996fdd18bda103712","hash":"e801e492487a055718a78ecdb6abfcf2114abcddd0f94f48464e27d5acbc78a6","source_role":"anecdotal_report"},{"id":"s39","type":"reddit","url":"https://www.reddit.com/r/CIRS/comments/1ncxx31/thymosinalpha_1/","title":"Thymosin-alpha 1 ??","quote":"Each herx reaction was slightly different but the first one, I felt “classicly sick”, like how normal people feel when they get the flu... Then after that they started to feel a bit more similar, usually severe fatigue plus normal viral symptoms. ... once I stabilize at each dose increase, I feel like I get about 2-3% of my life back.","summary":"Mixed: initial herx reactions (flu-like, fatigue, cytokine storm) but eventual positive slow improvements in symptoms and quality of life with titration.","author":"","publisher":"","date":"","claim_ids":["c45"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:03:23.964Z","link_status":"ok","quote_status":"unverified","prev":"e801e492487a055718a78ecdb6abfcf2114abcddd0f94f48464e27d5acbc78a6","hash":"042c814e39174e473562ae7fe839a563e096bb93b6b7a31e320ce0463e8ff8f9","source_role":"anecdotal_report"},{"id":"s40","type":"x","url":"https://x.com/CaneGrrl/status/2068318610662072812","title":"X post by @CaneGrrl","quote":"Anyone else experience sleep benefits with Thymosin Alpha-1? Could be a coincidence but my REM and deep sleep have gone up every night I’ve take it (which is only 3 so far, but still…)","summary":"Positive user-reported sleep improvement (increased REM and deep sleep) with TA-1 use.","author":"","publisher":"","date":"","claim_ids":["c46"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:03:23.964Z","link_status":"ok","quote_status":"verified","prev":"042c814e39174e473562ae7fe839a563e096bb93b6b7a31e320ce0463e8ff8f9","hash":"84db43541b45ba97e0fe949760d2cbae9e08f5f98b6d8202af6a1403324ede5f","source_role":"anecdotal_report"},{"id":"s41","type":"x","url":"https://x.com/quardoqu/status/2060338402189353350","title":"X post by @quardoqu","quote":"My top Long Covid treatments so far after six years in order of effectiveness out of a 100+: 1. LDN ... 2. Subq TA-1 (Thymosin Alpha 1) ...","summary":"Positive: TA-1 ranked as second most effective treatment for long COVID symptoms after 6 years.","author":"","publisher":"","date":"","claim_ids":["c47"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:03:23.964Z","link_status":"http_404","quote_status":"unverified","prev":"84db43541b45ba97e0fe949760d2cbae9e08f5f98b6d8202af6a1403324ede5f","hash":"fb23f602acb86a4de629ea91fe86041b3eb990e686c77ca9096bda4ea88062ae","source_role":"anecdotal_report"},{"id":"s42","type":"x","url":"https://x.com/quardoqu/status/2042676733057405170","title":"X post by @quardoqu","quote":"Any idea why Thymosin Alpha 1 takes my Long Covid symptoms away for 48 hours?","summary":"Positive: TA-1 eliminates long COVID symptoms for ~48 hours per dose.","author":"","publisher":"","date":"","claim_ids":["c48"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:03:23.964Z","link_status":"ok","quote_status":"verified","prev":"fb23f602acb86a4de629ea91fe86041b3eb990e686c77ca9096bda4ea88062ae","hash":"a1dabd0f4e86198de39c7ab87b8147889bb04e4f175dce5e26bfb3f51b2b846c","source_role":"anecdotal_report"},{"id":"s43","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12440967/","title":"Efficacy of thymosin α1 for sepsis: a systematic review and meta-analysis","quote":"In this updated meta-analysis, we found that thymosin alpha 1 (Tα1) may reduce 28-day mortality in patients with sepsis compared to the control group","summary":"2025 updated meta-analysis concluding Tα1 may reduce 28-day mortality in sepsis.","author":"","publisher":"","date":"","claim_ids":["c49"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:04:12.543Z","link_status":"ok","quote_status":"verified","prev":"a1dabd0f4e86198de39c7ab87b8147889bb04e4f175dce5e26bfb3f51b2b846c","hash":"07901af711c0441411b3de5321be0ec858054cfbdb234bfe329298f32aa9ca04","source_role":"mechanism_support"},{"id":"s44","type":"medical","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12883329/","title":"A Case Report of a Multisystemic Immune‐Related Adverse Event Induced by Thymosin Alpha‐1","quote":"Thymosin alpha‐1 (Tα1 ) is an immunomodulatory peptide known to play critical roles in T cell maturity and differentiation","summary":"2026 case report discussing immune-related adverse event from Tα1 use.","author":"","publisher":"","date":"","claim_ids":["c50"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:04:12.543Z","link_status":"ok","quote_status":"unverified","prev":"07901af711c0441411b3de5321be0ec858054cfbdb234bfe329298f32aa9ca04","hash":"cb45fd08318651ce5a70a4db5d31d87de9e631d1e8b6cc758200e56bacd667ad","source_role":"adjacent_context"},{"id":"s45","type":"medical","url":"https://journals.lww.com/imd/fulltext/2025/06000/expert_consensus_on_the_clinical_application_of.2.aspx","title":"Expert Consensus on the Clinical Application of Thymosin Alpha 1 in Infectious Diseases and Critical Care Medicine","quote":"10 recommendations on the application of Tα1 in treatment of liver diseases, viral infections, bacterial infections and critical illnesses.","summary":"2025 expert consensus with 10 recommendations for Tα1 in infectious diseases and critical care.","author":"","publisher":"","date":"","claim_ids":["c51"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:04:12.543Z","link_status":"ok","quote_status":"verified","prev":"cb45fd08318651ce5a70a4db5d31d87de9e631d1e8b6cc758200e56bacd667ad","hash":"2cf6d20a13578a0e0828328b37cccfb94cfcb4fd1f12cfc69c0d9fc9080edd32","source_role":"adjacent_context"},{"id":"s46","type":"other","url":"https://ascopubs.org/doi/10.1200/JCO.2025.43.16_suppl.e14606","title":"Thymosin alpha-1–enhanced PRaG regimen: A novel approach to boosting immune dynamics and therapeutic efficacy in advanced solid tumors","quote":"Thymosin Alpha 1 (Tα-1), a well-established immunomodulator, is known to protect lymphocytes, reduce lymphocytopenia during radiotherapy, and enhance T lymphocytes.","summary":"2025 ASCO abstract on Tα1 combined with PRaG regimen in solid tumors, reporting ORR and immune changes.","author":"","publisher":"","date":"","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:04:12.543Z","link_status":"http_403","quote_status":"unverified","prev":"2cf6d20a13578a0e0828328b37cccfb94cfcb4fd1f12cfc69c0d9fc9080edd32","hash":"e9a695a8a7d71a2731a18a4332bc5a5e4f13b46558ad3c7ad38959c10b5405e8","source_role":"adjacent_context"},{"id":"s47","type":"reddit","url":"https://www.reddit.com/r/IonPeptideGuide/comments/1tp86o7/thymalin_and_thymosin_alpha1_both_target_the/","title":"Thymalin and Thymosin Alpha-1 Both Target the Thymus","quote":"Thymosin Alpha-1 is a single defined 28-amino acid peptide sequence. It has an approved pharmaceutical form - Zadaxin - used clinically in over 35 countries","summary":"2025 Reddit discussion comparing Thymalin and TA1 mechanisms and uses.","author":"","publisher":"","date":"","claim_ids":["c53"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:04:12.543Z","link_status":"ok","quote_status":"unverified","prev":"e9a695a8a7d71a2731a18a4332bc5a5e4f13b46558ad3c7ad38959c10b5405e8","hash":"a5d870101ff12beb28636f4adfcd53511068c39c45d22531f8f3a4dcad025bf5","source_role":"anecdotal_report"},{"id":"s48","type":"x","url":"https://x.com/dogalyasalar/status/2067307286138143114","title":"GELİŞEN PEPTİD NOMENKLATÜRÜ","quote":"○ Bağışıklık Modülasyonu — Thymosin Alpha-1 (TA1) — Thymosin Beta-4 (TB-500) — LL-37 — KPV","summary":"2026 X post categorizing peptides including TA1 under immune modulation.","author":"","publisher":"","date":"","claim_ids":["c54"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:04:12.543Z","link_status":"ok","quote_status":"verified","prev":"a5d870101ff12beb28636f4adfcd53511068c39c45d22531f8f3a4dcad025bf5","hash":"ae9956e8194cda282cefe6ba1943be09a08860776864abaf22b4ea478b0a493e","source_role":"anecdotal_report"},{"id":"s49","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41883056/","title":"IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8+ ...","quote":"Conclusions: Combined IL-15 and Tα1 therapy reverses CD8 + T cell senescence and enhances antitumor immunity in HCC through suppression of the ...","summary":"2026 study on combined IL-15 and thymosin α1 therapy for hepatocellular carcinoma, reversing T cell senescence.","author":"","publisher":"","date":"","claim_ids":["c55"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:04:35.297Z","link_status":"ok","quote_status":"unverified","prev":"ae9956e8194cda282cefe6ba1943be09a08860776864abaf22b4ea478b0a493e","hash":"5b181d12f90a9df6d03377ad87c8f0b6443331aaa03570ac8f6a1144df35eb48","source_role":"mechanism_support"},{"id":"s50","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT04901104","title":"Long-term Prognosis of Patients With Sepsis After ...","quote":"Current clinical studies of thymosin α1 for sepsis have focused on short-term outcomes (28-day or 90-day mortality), and lack of clinical data on long-term ...","summary":"Ongoing trial on long-term prognosis after thymosin α1 in sepsis patients.","author":"","publisher":"","date":"","claim_ids":["c56"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:04:35.297Z","link_status":"ok","quote_status":"unverified","prev":"5b181d12f90a9df6d03377ad87c8f0b6443331aaa03570ac8f6a1144df35eb48","hash":"d3c40e66037ed42564e4b9c81e53135770440643e78fdafe7b5c15d00a92328f","source_role":"adjacent_context"},{"id":"s51","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41293232/","title":"Thymosin α1 Elevates Lymphocyte Counts and Improves ...","quote":"Tα1 treatment for 7 days significantly increased the median counts of peripheral blood total T cells (422.5/μL to 614.0 /μL, P<0.001), CD4 + T ...","summary":"2025 study showing thymosin α1 increases T cell counts in patients.","author":"","publisher":"","date":"","claim_ids":["c57"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:04:35.297Z","link_status":"ok","quote_status":"unverified","prev":"d3c40e66037ed42564e4b9c81e53135770440643e78fdafe7b5c15d00a92328f","hash":"2800e5883b9bd0af0b835ac18c0d3c8a0f2312ffe9ef5ff4bd1c952702a9cd2b","source_role":"mechanism_support"},{"id":"s52","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT06966687","title":"Protective Effect of Ulinastatin and Thymosin α1 Against ...","quote":"This study was designed to test the hypothesis that the administration of Ulinastatin and Thymosin α1 during the acute phase of AAS will result in a reduced ...","summary":"Trial on ulinastatin + thymosin α1 for acute aortic syndrome.","author":"","publisher":"","date":"","claim_ids":["c58"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:04:35.297Z","link_status":"ok","quote_status":"unverified","prev":"2800e5883b9bd0af0b835ac18c0d3c8a0f2312ffe9ef5ff4bd1c952702a9cd2b","hash":"f626ce42cb08923c196f1d50c26441ab37192ab5e8a9c8d78f753d4801bc93c2","source_role":"adjacent_context"},{"id":"s53","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40263352/","title":"The efficacy and safety of thymosin alpha-1 combined with ...","quote":"Thymosin α-1 combined with lenvatinib plus sintilimab is an effective and safe therapeutic regimen in unresectable hepatocellular carcinoma.","summary":"2025 study on thymosin α1 combo therapy for HCC.","author":"","publisher":"","date":"","claim_ids":["c59"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:04:35.297Z","link_status":"ok","quote_status":"verified","prev":"f626ce42cb08923c196f1d50c26441ab37192ab5e8a9c8d78f753d4801bc93c2","hash":"6031bd41fb73230d31357441cf767b5911f37d54a8636d2c43a9f96eabec086e","source_role":"mechanism_support"},{"id":"s54","type":"youtube","url":"https://www.youtube.com/watch?v=HgcNS3pkeyE","title":"Thymosin Alpha-1: Transforming Immunotherapy for ...","quote":"patient considerations associated with thymosin alpha 1 additionally we will review three clinical case studies to","summary":"Video discussing thymosin alpha 1 in immunotherapy with case studies.","author":"","publisher":"","date":"","claim_ids":["c60"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:04:35.297Z","link_status":"http_429","quote_status":"unverified","prev":"6031bd41fb73230d31357441cf767b5911f37d54a8636d2c43a9f96eabec086e","hash":"5c7da8985a388c08ec8593db0b28cd3d169666e50967809936554542d0c56163","source_role":"anecdotal_report"},{"id":"s55","type":"anecdotal","url":"https://www.evolutionary.org/forums/threads/thymosin-alpha-1-experiences-and-anecdotes-a-treatment-for-severe-allergies.109790/","title":"Thymosin Alpha 1 - experiences and anecdotes. A treatment for severe allergies?","quote":"I love TA1 and cycle it twice a year. In spring and fall. I'll mix it in other times if I'm feeling off. I personally use it to help my immune responses to both spring and fall allergies. It's worked well to have a lower response to the allergens.","summary":"Forum user reports positive cycling of TA1 for seasonal allergies, reduced response to allergens.","author":"","publisher":"","date":"","claim_ids":["c64"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:39:25.531Z","link_status":"http_403","quote_status":"unverified","prev":"5c7da8985a388c08ec8593db0b28cd3d169666e50967809936554542d0c56163","hash":"aadf7379b2a313f49c08c89665a10a4d37468d89708ff2216efd6d8d61844ad1","source_role":"anecdotal_report"},{"id":"s56","type":"anecdotal","url":"https://www.evolutionary.org/forums/threads/thymosin-alpha-1-experiences-and-anecdotes-a-treatment-for-severe-allergies.109790/","title":"Thymosin Alpha 1 - experiences and anecdotes. A treatment for severe allergies?","quote":"I put a mate onto Regenex as his eldest kid had Harishmotos disease and jumped on TA1 and apparently working well.","summary":"User reports positive results for Hashimoto's in a family member using TA1.","author":"","publisher":"","date":"","claim_ids":["c65"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:39:25.531Z","link_status":"http_403","quote_status":"unverified","prev":"aadf7379b2a313f49c08c89665a10a4d37468d89708ff2216efd6d8d61844ad1","hash":"a42b19695736bc338e61fbd2033b215e13d4981f451a72eb52a4ff133b0001db","source_role":"anecdotal_report"},{"id":"s57","type":"anecdotal","url":"https://www.ozarkholisticcenter.com/post/thymosin-alpha-1-the-immune-boosting-peptide-you-should-know-about","title":"Thymosin Alpha-1: The Immune-Boosting Peptide You Should Know About","quote":"One patient who had struggled with recurrent respiratory infections told us, “It feels like my body finally has its army back.”","summary":"Clinic reports patient testimonial of improved resilience against infections with TA1.","author":"","publisher":"","date":"","claim_ids":["c5"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:39:25.531Z","link_status":"ok","quote_status":"unverified","prev":"a42b19695736bc338e61fbd2033b215e13d4981f451a72eb52a4ff133b0001db","hash":"0f2f9bd7ae874147dd3eeb51f6477940ad5b084a81be4eab16e073f24c1d44cd","source_role":"anecdotal_report"},{"id":"s58","type":"reddit","url":"https://www.reddit.com/r/MCAS/comments/1lki5p2/best_peptides_and_brands_for_mcas_bpc157_kpv_and/","title":"Best peptides and brands for MCAS ? BPC-157, KPV and Thymosin / Thymogen ?","quote":"Don't use BCP for treating Mast Cell, honestly, for me thymosin-1 microdosing worked the best. Hard to get your hands on it, but a lab called Next Gen Peps was where I ended up at, pretty reliable & its a USA based.","summary":"User reports positive experience with Thymosin Alpha 1 microdosing for MCAS symptoms, better than BPC-157.","author":"","publisher":"","date":"","claim_ids":["c67"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:39:49.214Z","link_status":"ok","quote_status":"unverified","prev":"0f2f9bd7ae874147dd3eeb51f6477940ad5b084a81be4eab16e073f24c1d44cd","hash":"fb6ad3beaab050431b9dcc23b2b4ec87a6989856151e20aa972c63594623b302","source_role":"anecdotal_report"},{"id":"s59","type":"reddit","url":"https://www.reddit.com/r/Hashimotos/comments/1sylqox/peptides_anyone_taking_these/","title":"Peptides? Anyone taking these?","quote":"I will be testing my TPO at the 6 week mark in 2 weeks for TA-1. I was at 97 at the start, and I had actually done a single vial of 1 mg a day for 10 days and my Tpo had dropped about 10 points so I am hoping that was the cause and I can bring it down with a longer protocol.","summary":"User reports initial drop in TPO antibodies after short TA-1 course and plans longer protocol for Hashimoto's.","author":"","publisher":"","date":"","claim_ids":["c68"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:39:49.214Z","link_status":"ok","quote_status":"unverified","prev":"fb6ad3beaab050431b9dcc23b2b4ec87a6989856151e20aa972c63594623b302","hash":"419e18f0ba8abb8347a0e8b112a32f1e636a55ced5de5a0ab2fc0eabfb5bb436","source_role":"anecdotal_report"},{"id":"s60","type":"reddit","url":"https://www.reddit.com/r/chronicfatigue/comments/1j2z1az/what_resolved_my_chronic_fatigue_5_years_later/","title":"What resolved my chronic fatigue - 5 years later","quote":"Peptides: I have started taking Thymosin Alpha 1, Thymosin Beta 4, Semax and Selank. ... Thymosin Alpha 1 is an immune modulator so it helps improve the immune system. It also has anti inflammatory effects.","summary":"User starting TA1 as part of mold illness/CFS protocol, describes its expected immune modulating and anti-inflammatory benefits.","author":"","publisher":"","date":"","claim_ids":["c69"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:39:49.214Z","link_status":"ok","quote_status":"unverified","prev":"419e18f0ba8abb8347a0e8b112a32f1e636a55ced5de5a0ab2fc0eabfb5bb436","hash":"291b8326f8de108f42b028baf5edc1d8be18052591b442fe810ef3e59897218c","source_role":"anecdotal_report"},{"id":"s61","type":"reddit","url":"https://www.reddit.com/r/Peptides_for_Women/comments/1gy3d3a/thymosin_alpha_1/","title":"Thymosin Alpha 1","quote":"Within an hour felt significantly better, I mean total package of energy and good mood. ... Inflammation has been decreasing and histamine reaction is definitely getting better. ... within an hour I could do full range squats. Walking down stairs with full flexing and no pain. I’ve lost 3.5lbs of inflammation in 3 days.","summary":"User reports rapid improvement in energy, mood, allergies, inflammation, and chronic pain (e.g., plantar fasciitis-like symptoms) after starting TA-1 1mg every 3 days, with continued benefits and reduced allergy meds after weeks/months; some initial itchy/detox sensations but overall highly positive.","author":"","publisher":"","date":"","claim_ids":["c70"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:40:14.484Z","link_status":"ok","quote_status":"unverified","prev":"291b8326f8de108f42b028baf5edc1d8be18052591b442fe810ef3e59897218c","hash":"99834a4d101e7a9dd7ad7e836dd6a02064d892180a30fdd3657bccf6d1bd9273","source_role":"anecdotal_report"},{"id":"s62","type":"reddit","url":"https://www.reddit.com/r/Peptides_for_Women/comments/1gy3d3a/thymosin_alpha_1/","title":"Thymosin Alpha 1","quote":"TA1 is one of my favorite peptides! I’m allergic to animals but I love them. Was wrestling around w my brothers dog last night ... and left without washing my hands and did not wheeze, cough, choke or blow my nose. ... my first time, within 2 hours I can only compare my reaction to Covid like symptoms. ... lasted about eight hours.","summary":"Positive for reducing animal allergies and symptoms; initial flu-like reaction that resolved, leading to ongoing use.","author":"","publisher":"","date":"","claim_ids":["c71"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:40:14.484Z","link_status":"ok","quote_status":"unverified","prev":"99834a4d101e7a9dd7ad7e836dd6a02064d892180a30fdd3657bccf6d1bd9273","hash":"ed520a26e52bdc0e21a7008757cf3caa064298ea2f8ee608ff2811cd33aeacbb","source_role":"anecdotal_report"},{"id":"s63","type":"reddit","url":"https://www.reddit.com/r/covidlonghaulers/comments/1peun65/those_who_tried_peptides_permanent_shift_in/","title":"Those who tried peptides - permanent shift in baseline?","quote":"Thymosin-Alpha-1 _destroyed me_ - one 0.5mg injection and within 12 hours I had a severe flu-like immune reaction (fever, diarrhea, pins and needles, the works). The immune reaction continued the next day as well, and even after subsiding, I'm still crashed from it five days later - in the 70s whereas previously I was in the high 80s.","summary":"Severe negative experience with TA-1 causing prolonged flu-like immune reaction and crash in energy/function for Long COVID user.","author":"","publisher":"","date":"","claim_ids":["c72"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:40:14.484Z","link_status":"ok","quote_status":"unverified","prev":"ed520a26e52bdc0e21a7008757cf3caa064298ea2f8ee608ff2811cd33aeacbb","hash":"50f00c70c61b0bf69e958be3d6741613c2a99c41dac5b74b8d1a7573e5392157","source_role":"anecdotal_report"},{"id":"s64","type":"reddit","url":"https://www.reddit.com/r/covidlonghaulers/comments/1peun65/those_who_tried_peptides_permanent_shift_in/","title":"Those who tried peptides - permanent shift in baseline?","quote":"Thymosin alpha makes me feel acutely ill for a day or two.","summary":"User notes acute illness feeling from Thymosin alpha (TA-1), part of broader peptide experiences without permanent baseline shift.","author":"","publisher":"","date":"","claim_ids":["c73"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:40:14.484Z","link_status":"ok","quote_status":"unverified","prev":"50f00c70c61b0bf69e958be3d6741613c2a99c41dac5b74b8d1a7573e5392157","hash":"27f8e324571eea36b5833dbbc376a6c3cb5a8e87110a659ecb46a1ff43498b8d","source_role":"anecdotal_report"},{"id":"s65","type":"reddit","url":"https://www.reddit.com/r/tressless/comments/1rgcm86/peptide_for_alopecia_thymosin_alpha_1_as_an/","title":"Peptide for alopecia: Thymosin Alpha 1 as an Alternative to JAK Inhibitors","quote":"Hair loss due to Long Covid here, with TA-1 the hairs grew back.","summary":"Anecdotal positive report of hair regrowth from TA-1 in Long COVID-related hair loss.","author":"","publisher":"","date":"","claim_ids":["c74"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:40:14.484Z","link_status":"ok","quote_status":"unverified","prev":"27f8e324571eea36b5833dbbc376a6c3cb5a8e87110a659ecb46a1ff43498b8d","hash":"8657800bf5e8f21b2a96839681d98d5221ebbcfe9e5ae098b51b883cb7d91eef","source_role":"anecdotal_report"},{"id":"s66","type":"reddit","url":"https://www.reddit.com/r/covidlonghaulers/comments/1g2y1yx/thymosin_alpha_1_and_peptides_for_lc_discussed_on/","title":"Thymosin Alpha 1 and Peptides for LC Discussed on Huberman Lab","quote":"ME/CFS here - I’ve used TA1 and Thymulin with great success. I’ve had to increase the dose and I can still overdo it and cause PEM and I have to take it daily or the benefit is lost but….it absolutely provides a lift in energy and brain fog and functionality.","summary":"User reports great success with TA1 (and Thymulin) for ME/CFS/LC symptoms including energy, brain fog, and functionality; notes need to increase dose over time and daily use for benefit, risk of PEM if overdone.","author":"","publisher":"","date":"","claim_ids":["c75"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:40:50.201Z","link_status":"ok","quote_status":"unverified","prev":"8657800bf5e8f21b2a96839681d98d5221ebbcfe9e5ae098b51b883cb7d91eef","hash":"b5d2c77cd372142a469d311e7b7e9ca962382b5d305137eeb46b848af6180a38","source_role":"anecdotal_report"},{"id":"s67","type":"reddit","url":"https://www.reddit.com/r/covidlonghaulers/comments/1g2y1yx/thymosin_alpha_1_and_peptides_for_lc_discussed_on/","title":"Thymosin Alpha 1 and Peptides for LC Discussed on Huberman Lab","quote":"Nice! I just did a cycle which caused a lot of side effects. I thought I'd made a huge mistake, but once I stopped taking it, I found my baseline came back higher.","summary":"User experienced significant side effects during cycle (fatigue without activity, muscle twitching, chills) but reported improved baseline after stopping; restarting at lower dose.","author":"","publisher":"","date":"","claim_ids":["c76"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:40:50.201Z","link_status":"ok","quote_status":"unverified","prev":"b5d2c77cd372142a469d311e7b7e9ca962382b5d305137eeb46b848af6180a38","hash":"b6f99db4858ad8bb97815ee7a8fd9abb57a32e25bcbedbfa180443f9d9879b35","source_role":"anecdotal_report"},{"id":"s68","type":"x","url":"https://x.com/thecoercednurse/status/2070187778584047692","title":"X post by @thecoercednurse","quote":"It helped to stop the progression of my immune/cardiovascular/respiratory failure. Decreased the debilitating muscle spasms. Improved my ADL function. Kept my autonomic swings more level. Essentially stopped me from needing to choose hospice/palliative care as my only option.","summary":"User reports major positive outcomes from TA1 including halting disease progression, reducing spasms, improving daily function and autonomic stability in context of long vax/LC.","author":"","publisher":"","date":"","claim_ids":["c77"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:40:50.201Z","link_status":"ok","quote_status":"verified","prev":"b6f99db4858ad8bb97815ee7a8fd9abb57a32e25bcbedbfa180443f9d9879b35","hash":"43479f1c41481425509f4cbe43c666f25569e7bbf21e3d99f34c07b880f86826","source_role":"anecdotal_report"},{"id":"s69","type":"x","url":"https://x.com/squarian24/status/2070542926623490303","title":"X post by @squarian24","quote":"I’m being very serious. There’s minimal side effects, no long term effects have been shown after a near decade of studies, and it works.","summary":"Positive user endorsement of TA1 with minimal side effects and efficacy based on personal experience and studies.","author":"","publisher":"","date":"","claim_ids":["c78"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:40:50.201Z","link_status":"ok","quote_status":"verified","prev":"43479f1c41481425509f4cbe43c666f25569e7bbf21e3d99f34c07b880f86826","hash":"079575e015d67d272f93109dfa61faee59697a1d8f6b2c7c120801cfb344812e","source_role":"anecdotal_report"},{"id":"s70","type":"reddit","url":"https://www.reddit.com/r/pancreaticcancer/comments/x71x4v/thymosin_alpha_1/","title":"Thymosin Alpha 1","quote":"I did find some pre clinical evidence that Thymosin Alpha 1 was protective against opportunistic infection due to suppression from 5-flurouracil.","summary":"Discussion on using TA-1 for pancreatic cancer patient; anecdotal interest in immune modulation, no personal outcomes shared in snippet.","author":"","publisher":"","date":"","claim_ids":["c79"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:42:30.624Z","link_status":"ok","quote_status":"unverified","prev":"079575e015d67d272f93109dfa61faee59697a1d8f6b2c7c120801cfb344812e","hash":"52576ddab0862a0b256905de8246689ec10a74a6bf5bef6bd438acef37304fb7","source_role":"anecdotal_report"},{"id":"s71","type":"reddit","url":"https://www.reddit.com/r/Hashimotos/comments/1sxdk9m/zadaxin_thymosin_alpha1ta1_peptide_to_help_slow/","title":"Zadaxin Thymosin alpha-1(TA-1) peptide to help slow muscle recovery?","quote":"Thymosin Alpha 1 is more for immunoregulation, ie those pesky T cells.","summary":"Anecdotal thread on TA-1 for Hashimoto's and muscle recovery; one user notes it for immunoregulation.","author":"","publisher":"","date":"","claim_ids":["c80"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:42:30.624Z","link_status":"ok","quote_status":"unverified","prev":"52576ddab0862a0b256905de8246689ec10a74a6bf5bef6bd438acef37304fb7","hash":"e19a6d5a38273f8e38a9db15b91f7fa79fabeace000edb16fc2586d7c2b95271","source_role":"anecdotal_report"},{"id":"s72","type":"reddit","url":"https://www.reddit.com/r/AutoImmuneProtocol/comments/1rzrql8/thymosin_alpha1/","title":"Thymosin Alpha-1","quote":"Anyone has tried Thymosin Alpha-1 for Graves autoimmune? If not, what worked for you to drop your antibodies?","summary":"Query seeking experiences with TA-1 for Graves' disease autoimmune condition.","author":"","publisher":"","date":"","claim_ids":["c81"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:42:30.624Z","link_status":"ok","quote_status":"unverified","prev":"e19a6d5a38273f8e38a9db15b91f7fa79fabeace000edb16fc2586d7c2b95271","hash":"695189da2a251c1dff219e6743fd3796fd3e82b52a1237c38a89f8448cee5672","source_role":"anecdotal_report"},{"id":"s73","type":"reddit","url":"https://www.reddit.com/r/endometriosis/comments/1s8dkwf/thymosin_alpha_1_ldn_or_glps_or_all_three/","title":"Thymosin Alpha 1, LDN, or GLPS? or all three?","quote":"My dr wants me on TA1 for chronic EBV as well and heard it might possibly help immune system fight off endo.","summary":"Anecdotal discussion of TA-1 dosing for chronic EBV and potential endometriosis benefits; labeled anecdotal.","author":"","publisher":"","date":"","claim_ids":["c82"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:42:30.624Z","link_status":"ok","quote_status":"unverified","prev":"695189da2a251c1dff219e6743fd3796fd3e82b52a1237c38a89f8448cee5672","hash":"03f97a8618ba8b61fb4c243ab6f80e0b6d6ef71cc90ef4f1e2497ee5bc2e63bc","source_role":"anecdotal_report"},{"id":"s74","type":"x","url":"https://x.com/BhavanChand/status/2071648123559288889","title":"Thymosin Alpha-1 testing","quote":"My kids caught cold again 3 days ago My mother also caught cold from them It didn't spread to me yet and I didn't take my Thymosin Alpha -1 Testing if the previous doses are working or not","summary":"Anecdotal X post testing prior TA-1 doses for cold prevention; no outcome reported yet.","author":"","publisher":"","date":"","claim_ids":["c83"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:42:30.624Z","link_status":"ok","quote_status":"unverified","prev":"03f97a8618ba8b61fb4c243ab6f80e0b6d6ef71cc90ef4f1e2497ee5bc2e63bc","hash":"421c2034f38785596eec425a91e54e81f6ac9103d57060c17fc9f6922d9d2e84","source_role":"anecdotal_report"},{"id":"s75","type":"x","url":"https://x.com/biotides/status/2071620162831159366","title":"Thymosin Alpha-1 for sinusitis","quote":"For someone who suffers from sinusitis, one of the best remedies I’ve used is Thymosin Alpha-1. I use it as needed. But it almost immediately opens the sinuses up and cleans out the gunk. Same with the throat.","summary":"Positive anecdotal report on TA-1 for sinusitis relief (as needed dosing); good outcome claimed.","author":"","publisher":"","date":"","claim_ids":["c84"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:42:30.624Z","link_status":"ok","quote_status":"verified","prev":"421c2034f38785596eec425a91e54e81f6ac9103d57060c17fc9f6922d9d2e84","hash":"45937974f74474ce89e5a6fd592beacedfad59b7817849d0875825559e65447b","source_role":"anecdotal_report"},{"id":"s76","type":"x","url":"https://x.com/DuaneStorey/status/2071544627635581270","title":"RNA seq data with TA1","quote":"Day 0 meds: baseline, Thymosin Alpha 1 for a few days. ... Good news is a substantial amount of my out of range genes went back into range on day 42.","summary":"Anecdotal personal RNA sequencing results involving TA-1 use; mixed with other meds, positive gene expression changes noted.","author":"","publisher":"","date":"","claim_ids":["c85"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:42:30.624Z","link_status":"ok","quote_status":"unverified","prev":"45937974f74474ce89e5a6fd592beacedfad59b7817849d0875825559e65447b","hash":"d4f11e46c63e5b2dcc21e964c214f83b7633b7b14dc0e02666b71cb0adccaac7","source_role":"anecdotal_report"},{"id":"s77","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1phisi1/thymosin_alpha_1/","title":"Thymosin Alpha 1","quote":"It's a risky gamble imo. There is a small subset of SFN patients who I would expect to get modestly better from Ta1, with the rest either getting no benefit or even feeling _worse_. You don't want to jack up T cell activity if T cell activity is already problematic.","summary":"Comment discusses potential risks and benefits of TA1 for small fiber neuropathy (SFN), noting it may worsen symptoms in some due to T-cell stimulation; recommends labs first. Anecdotal, not advice.","author":"","publisher":"","date":"","claim_ids":["c86"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:43:05.376Z","link_status":"ok","quote_status":"unverified","prev":"d4f11e46c63e5b2dcc21e964c214f83b7633b7b14dc0e02666b71cb0adccaac7","hash":"a6e09fff0185217a2edcdc7ccde7b0895ad880edc1fc0ea0492811f80b697996","source_role":"anecdotal_report"},{"id":"s78","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1phisi1/thymosin_alpha_1/","title":"Thymosin Alpha 1","quote":"I just started! Haven’t seen any results or had any relief yet but I will keep you posted!","summary":"User reports starting TA1 (second week on full dose after slow start) with no results yet for SFN symptoms; also on ARA-290. Anecdotal, not advice.","author":"","publisher":"","date":"","claim_ids":["c87"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:43:05.376Z","link_status":"ok","quote_status":"unverified","prev":"a6e09fff0185217a2edcdc7ccde7b0895ad880edc1fc0ea0492811f80b697996","hash":"d082482f9a8e7a99e8307a0fff120667f2ba36366b05be12cad40274af1bcb2d","source_role":"anecdotal_report"},{"id":"s79","type":"reddit","url":"https://www.reddit.com/r/Immunology/comments/q6bgrz/thymosin_alpha_1_daily_vs_twice_weekly/","title":"Thymosin alpha 1 daily vs twice weekly administration","quote":"I basically get more ill for a few days every time I take the TA1. So it’s a bit of a hinderance to general work and life stuff. I might try lower doses to see if that is easier to handle.","summary":"User reports side effects like feeling more ill (HRV tanked, breathless, wired) after 1-1.2mg doses of TA1 for long COVID; considering lower doses. Dosing anecdote: 800mcg 2-3x/week planned. Anecdotal, not advice.","author":"","publisher":"","date":"","claim_ids":["c88"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:43:05.376Z","link_status":"ok","quote_status":"unverified","prev":"d082482f9a8e7a99e8307a0fff120667f2ba36366b05be12cad40274af1bcb2d","hash":"4f8746ff75f51e816a906e7c01fab4417b8ad049154615e9882bd7aaefa6e76a","source_role":"anecdotal_report"},{"id":"s80","type":"reddit","url":"https://www.reddit.com/r/Immunology/comments/q6bgrz/thymosin_alpha_1_daily_vs_twice_weekly/","title":"Thymosin alpha 1 daily vs twice weekly administration","quote":"I’m thinking of doing 2-3x a week around 800mcg after starting at 300mcg to see if I react to it. I’ll also run TB-500 for healing.","summary":"Dosing discussion and plan for TA1 (starting low at 300mcg, then 800mcg 2-3x/week) alongside other peptides for long COVID immune issues. Anecdotal, not advice.","author":"","publisher":"","date":"","claim_ids":["c89"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:43:05.376Z","link_status":"ok","quote_status":"unverified","prev":"4f8746ff75f51e816a906e7c01fab4417b8ad049154615e9882bd7aaefa6e76a","hash":"7d10e3f67b639e32213f893a753ae85243c8a50d5817e82ba347af1df8e02d43","source_role":"anecdotal_report"},{"id":"s81","type":"reddit","url":"https://www.reddit.com/r/PeptideProgress/comments/1s62nmn/thymosin_alpha1_the_immune_system_peptide_nobody/","title":"Thymosin Alpha-1: The Immune System Peptide Nobody Talks About","quote":"The people who tend to benefit most from Thymosin Alpha - 1 are those dealing with frequent illness, slow recovery from infections, chronic fatigue, and autoimmune issues.","summary":"Post discusses potential benefits of TA1 for immune support in chronic conditions; no specific personal outcomes or dosing in snippet but contextual anecdotes implied in community. Anecdotal context, not advice.","author":"","publisher":"","date":"","claim_ids":["c90"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:43:05.376Z","link_status":"ok","quote_status":"unverified","prev":"7d10e3f67b639e32213f893a753ae85243c8a50d5817e82ba347af1df8e02d43","hash":"2bb2110fc15d122321b88f3b9880f40197c7a36a204c8649c0bf43c4484cb7e8","source_role":"anecdotal_report"},{"id":"s82","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1p43fnb/thymosin_alpha1_immune_system_peptide_explained/","title":"Thymosin Alpha-1 🏥 Immune System Peptide Explained | T-Cell Activation, Inflammation Control & Recovery Support (Complete 2025 Research Guide)","quote":"TA1 isn’t one of those “immune booster” things. It doesn’t just crank your immune system up. It’s more like helping it work normally again, especially after burnout or chronic stress.","summary":"Guide explaining TA-1 as immunomodulator not booster; discusses clinical uses, dosing (e.g., 1.6mg 2-3x weekly anecdotal), possible mild side effects like initial fatigue. Anecdotal user experiences labeled as such.","author":"","publisher":"","date":"","claim_ids":["c5"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:43:45.543Z","link_status":"ok","quote_status":"unverified","prev":"2bb2110fc15d122321b88f3b9880f40197c7a36a204c8649c0bf43c4484cb7e8","hash":"e50abfc806fb93cc5701102cb2241e54e8d0b76417a86edb05e5ea9754fd57b1","source_role":"anecdotal_report"},{"id":"s83","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1p43fnb/thymosin_alpha1_immune_system_peptide_explained/","title":"Thymosin Alpha-1 🏥 Immune System Peptide Explained | T-Cell Activation, Inflammation Control & Recovery Support (Complete 2025 Research Guide)","quote":"I got some blood work done and it recommended I take TA1 for chronic inflammation. ... TA-1 tends to help people. ... You feel less inflamed or “worn down”, you bounce back faster when you’re tired or sick.","summary":"User with chronic stress/burnout considering TA-1 based on bloodwork; OP responds with expected subtle benefits like better resilience (anecdotal dosing and outcomes only).","author":"","publisher":"","date":"","claim_ids":["c92"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:43:45.543Z","link_status":"ok","quote_status":"unverified","prev":"e50abfc806fb93cc5701102cb2241e54e8d0b76417a86edb05e5ea9754fd57b1","hash":"5cc7469301ebf3eac9ab0f18f334656fcb2fb5a1362b4cc193678046e9bfbfd5","source_role":"anecdotal_report"},{"id":"s84","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1s5cv2z/ta1_cloudy_at_reconstitution/","title":"Ta1 Cloudy at Reconstitution","quote":"I have tried two different vials of Thymosin Alpha 1 from the same source and both are cloudy with suspended ...","summary":"User reports cloudy reconstitution of TA1 vials from same source (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c93"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:44:27.544Z","link_status":"ok","quote_status":"unverified","prev":"5cc7469301ebf3eac9ab0f18f334656fcb2fb5a1362b4cc193678046e9bfbfd5","hash":"bccdadf6c337a85b352c55cc9adab34ae636e7c8892b43f6738882d55aa5ddcb","source_role":"anecdotal_report"},{"id":"s85","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1hhefnv/ll37_thymosin_alpha_review/","title":"LL37 & Thymosin Alpha Review","quote":"I have begun a LL37 and Thymosin Alpha cycle, this time for the exact purpose of healing the body in all the ways these peptides are said to do.","summary":"Anecdotal report of starting LL37 and Thymosin Alpha cycle for healing (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c94"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:44:27.544Z","link_status":"ok","quote_status":"unverified","prev":"bccdadf6c337a85b352c55cc9adab34ae636e7c8892b43f6738882d55aa5ddcb","hash":"b4100b724c7f8245c913a1fc957fc63f8ca0eea62b28aaaf3214aa09e54b54a9","source_role":"anecdotal_report"},{"id":"s86","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1d2d4s2/thymosin_alpha_1_is_there_a_way_to_check_from/","title":"Thymosin Alpha 1: Is there a way to check from bloodwork ...","quote":"I ordered some Thymosin Alpha 1 recently and will be trying it soon for the first time. I'll be using it to try and treat a chronic ...","summary":"User planning to try TA1 for chronic issue, seeking bloodwork monitoring (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c95"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:44:27.544Z","link_status":"ok","quote_status":"unverified","prev":"b4100b724c7f8245c913a1fc957fc63f8ca0eea62b28aaaf3214aa09e54b54a9","hash":"abf738fd42dc43818d8f301339f14ff69cdf66968d5014165007ad5fb6dd26a4","source_role":"anecdotal_report"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23327199/","title":"The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial (Crit Care 2013; PMID 23327199; NCT00711620)","quote":"Greater improvement of mHLA-DR was observed in the Ta1 group on day 3 (mean difference 3.9%, 95% CI 0.2 to 7.6%, P = 0.037) and day 7 (5.8%, 95% CI 1.0 to 10.5%, P = 0.017). No serious drug-related adverse event was recorded.","_id":"w_1hp6ddar","_ts":"2026-08-04T08:35:34.825Z","id":"w_1hp6ddar","type":"source","accessed_at":"2026-08-04T08:35:34.825Z","claim_ids":[],"prev":"abf738fd42dc43818d8f301339f14ff69cdf66968d5014165007ad5fb6dd26a4","hash":"56166a416dee0c8cc0853a8673d3a04877728be61496119eecd741c05204643a","summary":"ETASS randomised controlled trial of thymosin alpha 1 in severe sepsis: monocyte HLA-DR recovery and safety findings."},{"url":"https://pubmed.ncbi.nlm.nih.gov/23327199/","title":"The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial (Crit Care 2013; PMID 23327199; NCT00711620)","quote":"The mortalities from any cause within 28 days in the Ta1 group and control group were 26.0% and 35.0% respectively with a marginal P value (nonstratified analysis, P = 0.062; log rank, P = 0.049)","_id":"w_zlvvtukb","_ts":"2026-08-04T08:35:51.920Z","id":"w_zlvvtukb","type":"source","accessed_at":"2026-08-04T08:35:51.920Z","claim_ids":[],"prev":"56166a416dee0c8cc0853a8673d3a04877728be61496119eecd741c05204643a","hash":"2427352caadb1cb67b0a353b8323f819551f91ecb780455a6ebeb6af73ec1262","plain":"An early multicentre randomized trial in severe sepsis. Death within 28 days ran 26% against 35%, but only one of the two statistical tests crossed the line and the trial was single-blind. Grounds for a bigger study, not a settled answer."},{"url":"https://pubmed.ncbi.nlm.nih.gov/39814420/","title":"The efficacy and safety of thymosin alpha1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial (BMJ 2025; PMID 39814420; NCT02867267)","quote":"28 day all cause mortality occurred in 127 participants (23.4%) in the thymosin alpha1 group and 132 (24.1%) in the placebo group (hazard ratio 0.99, 95% confidence interval 0.77 to 1.27; P=0.93)","_id":"w_vzvtwnky","_ts":"2026-08-04T08:35:53.253Z","id":"w_vzvtwnky","type":"source","accessed_at":"2026-08-04T08:35:53.253Z","claim_ids":[],"prev":"2427352caadb1cb67b0a353b8323f819551f91ecb780455a6ebeb6af73ec1262","hash":"8362a2b1b6be412687a065f4c25935835f50cac390360cdaa54d3459e56b172e","plain":"The proper test: double-blind, placebo-controlled, phase 3, over a thousand people with sepsis. Deaths at 28 days were the same in both arms, with a hazard ratio of essentially 1.0. It is the strongest design in the entire record and it found nothing."},{"url":"https://pubmed.ncbi.nlm.nih.gov/35713670/","title":"Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial (TRACE, Intensive Care Med 2022; PMID 35713670; NCT02473406)","quote":"40/254(15.7%) patients in the Ta1 group developed IPN compared with 46/254 patients (18.1%) in the placebo group (difference -2.4% [95% CI - 7.4 to 5.1%]; p = 0.48)","_id":"w_0c2625io","_ts":"2026-08-04T08:35:56.546Z","id":"w_0c2625io","type":"source","accessed_at":"2026-08-04T08:35:56.546Z","claim_ids":[],"prev":"8362a2b1b6be412687a065f4c25935835f50cac390360cdaa54d3459e56b172e","hash":"2b2760ff9c992e286558f6d160aeaa26f1677392b2fa6d58e7368b9b4f6bfefb","plain":"508 people with severe pancreatitis, randomized and double-blind. Infected dead tissue appeared in 15.7% on the peptide and 18.1% on placebo, a gap too small to separate from chance. The main question the trial was built to answer came back negative."},{"url":"https://pubmed.ncbi.nlm.nih.gov/37007743/","title":"Association between pretreatment lymphocyte count and efficacy of immune-enhancing therapy in acute necrotising pancreatitis: post-hoc analysis of TRACE (EClinicalMedicine 2023; PMID 37007743)","quote":"Within the subgroup of patients with baseline ALC>=0.8 x 10^9/L (n = 290), the Ta1 therapy significantly reduced the risk of IPN (covariate adjusted risk difference, -0.12; 95% CI, -0.21,-0.02; p = 0.015)","_id":"w_cbj4dxj3","_ts":"2026-08-04T08:36:02.145Z","id":"w_cbj4dxj3","type":"source","accessed_at":"2026-08-04T08:36:02.145Z","claim_ids":[],"prev":"2b2760ff9c992e286558f6d160aeaa26f1677392b2fa6d58e7368b9b4f6bfefb","hash":"d2e3f08e4f7cc9ec2723e8640d903f089e7790804c86e473dc92827b77ed8687","plain":"A slice of the pancreatitis trial cut open after the results were known: among the 290 who started with enough lymphocytes, the peptide arm did better. Subgroups found after the fact raise a question for the next trial. They do not answer one."},{"url":"https://pubmed.ncbi.nlm.nih.gov/32442287/","title":"Thymosin Alpha 1 Reduces the Mortality of Severe Coronavirus Disease 2019 by Restoration of Lymphocytopenia and Reversion of Exhausted T Cells (Clin Infect Dis 2020; PMID 32442287)","quote":"Compared with the untreated group, Ta1 treatment significantly reduced the mortality of severe COVID-19 patients (11.11% vs 30.00%, P = .044)","_id":"w_or6weneu","_ts":"2026-08-04T08:36:03.028Z","id":"w_or6weneu","type":"source","accessed_at":"2026-08-04T08:36:03.028Z","claim_ids":[],"prev":"d2e3f08e4f7cc9ec2723e8640d903f089e7790804c86e473dc92827b77ed8687","hash":"ad4e1a7f579c47489886a81882e59f471092808845cd6a44bdb4b430e55a6c01","plain":"An early-pandemic hospital comparison rather than a randomized trial, setting patients who got the peptide against those who did not. The mortality gap is wide, and so is the room for the two groups differing in ways nobody measured."},{"url":"https://pubmed.ncbi.nlm.nih.gov/34408744/","title":"Efficacy of Thymosin Alpha 1 in the Treatment of COVID-19: A Multicenter Cohort Study (Front Immunol 2021; PMID 34408744)","quote":"After adjusting for confounding factors, Ta1 use was found to be significantly associated with a higher non-recovery rate than non-Ta1 use (OR 1.5, 95% CI 1.1-2.1, p = 0.028)","_id":"w_q4kpjhai","_ts":"2026-08-04T08:36:04.691Z","id":"w_q4kpjhai","type":"source","accessed_at":"2026-08-04T08:36:04.691Z","claim_ids":[],"prev":"ad4e1a7f579c47489886a81882e59f471092808845cd6a44bdb4b430e55a6c01","hash":"b4195ccb337daa191abc31e1f36468f5875735c95755887b73fec8ee066fbe31","plain":"A multi-hospital observational study pointing the other way from the smaller COVID reports: after adjustment, people given the peptide were about half again as likely not to have recovered. Observational, so not proof of harm, but it belongs beside the positive ones."},{"url":"https://pubmed.ncbi.nlm.nih.gov/33968969/","title":"Efficacy Evaluation of Thymosin Alpha 1 in Non-severe Patients With COVID-19: A Retrospective Cohort Study Based on Propensity Score Matching (Front Med 2021; PMID 33968969)","quote":"the Thymosin-alpha1 group had significantly shorter SARS-CoV-2 RNA shedding duration (13 vs. 16 days, p = 0.025) and hospital stay (14 vs. 18 days, p < 0.001)","_id":"w_vxfrwa56","_ts":"2026-08-04T08:36:06.281Z","id":"w_vxfrwa56","type":"source","accessed_at":"2026-08-04T08:36:06.281Z","claim_ids":[],"prev":"b4195ccb337daa191abc31e1f36468f5875735c95755887b73fec8ee066fbe31","hash":"cbb90a0f7948ef73c1e2941b2854a999bdc8d4790d8499550f6cad9fa34107fa","plain":"A look back through records of people with milder COVID, statistically matched to make the two groups comparable. Virus clearance and hospital stay were each a few days shorter. Matching narrows the gap between groups but never closes it the way randomizing does."},{"url":"https://clinicaltrials.gov/study/NCT04428008","title":"A Pilot Trial of Thymalfasin (Ta1) to Prevent COVID-19 Infection in Renal Dialysis Patients (NCT04428008, posted results)","quote":"Number of Participants With COVID-19 Infection: Active Arm 5, Control Arm 7. Deaths: Active Arm 3/91, Control Arm 7/98.","_id":"w_jzf25pn3","_ts":"2026-08-04T08:36:06.920Z","id":"w_jzf25pn3","type":"source","accessed_at":"2026-08-04T08:36:06.920Z","claim_ids":[],"prev":"cbb90a0f7948ef73c1e2941b2854a999bdc8d4790d8499550f6cad9fa34107fa","hash":"262f3cb69051fc1ff58afa1e1bb86cab4e50115f809b3b697f05384ffc10c0f2","plain":"A small pilot in dialysis patients, with its results actually posted. Five infections against seven, three deaths against seven. Numbers this size move on chance alone, so what it shows is that the study could be run, not that the peptide did anything."},{"url":"https://clinicaltrials.gov/study/NCT00911443","title":"Phase II dose-ranging trial of dacarbazine plus interferon alpha plus thymosin alpha-1 in advanced metastatic melanoma (NCT00911443, posted results, n=488)","quote":"Overall Survival, months: DTIC+IFN+Ta1 6.4 mg 10.3; DTIC+Ta1 3.2 mg 9.3; DTIC+IFN+Ta1 1.6 mg 9.3; DTIC+IFN+Ta1 3.2 mg 8.6; DTIC+IFN alone 6.6","_id":"w_omh8z65r","_ts":"2026-08-04T08:36:07.988Z","id":"w_omh8z65r","type":"source","accessed_at":"2026-08-04T08:36:07.988Z","claim_ids":[],"prev":"262f3cb69051fc1ff58afa1e1bb86cab4e50115f809b3b697f05384ffc10c0f2","hash":"93ef23eba4b73c3492ef9bdf7c1deb63ac5bc41200dce66ee095a8c8b3e7eace","plain":"A 488-person dose-ranging study in advanced melanoma. Median survival across the four peptide doses ran 8.6 to 10.3 months against 6.6 for the standard combination, with no clean pattern by dose, in a trial not designed to prove a survival benefit."},{"url":"https://clinicaltrials.gov/study/NCT01178996","title":"Phase III trial of thymosin alpha 1 plus peginterferon alfa-2a plus ribavirin in chronic hepatitis C non-responders (NCT01178996, n=552, completed 2009, no results posted)","quote":"Thymosin alpha 1 (Zadaxin) 1.6 mg/day, two times weekly in the morning, by subcutaneous injection for 48 weeks. Primary outcome: Sustained Virological Response (SVR) at Week 72.","_id":"w_xmbjsj3u","_ts":"2026-08-04T08:36:09.161Z","id":"w_xmbjsj3u","type":"source","accessed_at":"2026-08-04T08:36:09.161Z","claim_ids":[],"prev":"93ef23eba4b73c3492ef9bdf7c1deb63ac5bc41200dce66ee095a8c8b3e7eace","hash":"dd25e3d922ac730e3fe1ec04eb87829478034205faabea89cc71c0d939ec355c","plain":"A 552-person phase 3 in hepatitis C that finished in 2009 and never posted a result. A completed trial that size going dark is itself information: the published record is missing a piece it ought to contain."},{"url":"https://clinicaltrials.gov/study/NCT05086614","title":"Thymosin-alpha 1 as adjuvant treatment after radical resection of high-risk stage II and III colorectal cancer (NCT05086614, phase 3, 2500 planned, primary completion 2027)","quote":"Receive thymosin-alpha 1 1.6mg with subcutaneous injection, twice a week, for 6 months after radical resection. Primary outcome: 3-year disease-free survival rate.","_id":"w_dkfbbahz","_ts":"2026-08-04T08:36:10.476Z","id":"w_dkfbbahz","type":"source","accessed_at":"2026-08-04T08:36:10.476Z","claim_ids":[],"prev":"dd25e3d922ac730e3fe1ec04eb87829478034205faabea89cc71c0d939ec355c","hash":"802723d64ae9e44d27bfec7c61198badeb08e77e9f2c491340971898a3868d29","plain":"A phase 3 planning 2,500 people, asking whether six months of the peptide after bowel cancer surgery changes how many stay disease-free at three years. Primary completion is 2027, so it moves what will be knowable, not what is known."},{"url":"https://pubmed.ncbi.nlm.nih.gov/22178096/","title":"Thymosin-alpha 1 (Zadaxin) enhances the immunogenicity of an adjuvated pandemic H1N1v influenza vaccine (Focetria) in hemodialyzed patients: a pilot study (Vaccine 2012; PMID 22178096)","quote":"The CHMP criteria were fully met in the groups treated with Vaccine+Thymosin alpha 1. No AE was found to be related to Thymosin alpha 1 nor to the Focetria vaccine.","_id":"w_23spjiq3","_ts":"2026-08-04T08:36:13.358Z","id":"w_23spjiq3","type":"source","accessed_at":"2026-08-04T08:36:13.358Z","claim_ids":[],"prev":"802723d64ae9e44d27bfec7c61198badeb08e77e9f2c491340971898a3868d29","hash":"bc7eaefab13e48f05481e0c788a2ec4f51662beec32e2418acaf9c3d62a30c8c","plain":"A small pilot adding the peptide to a flu shot in dialysis patients, whose response to vaccines is usually poor. The combined group met the regulator's antibody thresholds and no side effect was traced to the peptide. Pilot-sized, so a signal and nothing firmer."},{"url":"https://pubmed.ncbi.nlm.nih.gov/17804687/","title":"Thymosin alpha1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo (Int Immunol 2007; PMID 17804687)","quote":"The anti-viral effect of Talpha1 occurred through the activation of plasmacytoid DCs via the TLR9/myeloid differentiation primary response gene 88-dependent viral recognition sensing, leading to the activation of IFN regulatory factor 7","_id":"w_e7vuijxz","_ts":"2026-08-04T08:36:19.675Z","id":"w_e7vuijxz","type":"source","accessed_at":"2026-08-04T08:36:19.675Z","claim_ids":[],"prev":"bc7eaefab13e48f05481e0c788a2ec4f51662beec32e2418acaf9c3d62a30c8c","hash":"ed5070c50b236c3a4556dd2b99132e1b401a7e33d7bac62c08f1e233234044bf","plain":"Mice, and a mechanism. The antiviral effect ran through one specific immune-sensing pathway in a class of dendritic cells. It offers a plausible route of action and carries nothing about dose, benefit, or what happens in a person."},{"url":"https://pubmed.ncbi.nlm.nih.gov/17495242/","title":"Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerance (Ann N Y Acad Sci 2007; PMID 17495242)","quote":"Talpha1 primed DCs for antifungal Th1 resistance through Toll-like receptor (TLR)/MyD88-dependent signaling; activated plasmacytoid DCs via TLR9/MyD88-dependent viral recognition; induced indoleamine 2,3-dioxygenase activity in DCs, thus affecting tolerization toward self as well as microbial non-self-antigens","_id":"w_pptae9m4","_ts":"2026-08-04T08:36:33.407Z","id":"w_pptae9m4","type":"source","accessed_at":"2026-08-04T08:36:33.407Z","claim_ids":[],"prev":"ed5070c50b236c3a4556dd2b99132e1b401a7e33d7bac62c08f1e233234044bf","hash":"fa157b0804c5dff81666fe68865e8db5677a305d3550e9c28e6cda6f210eb19b","plain":"A mechanism review from the group that mapped the pathway, describing how the peptide tunes dendritic cells both toward fighting infection and toward tolerating the body's own tissue. Background for why it was tried in people, not evidence from people."},{"url":"https://pubmed.ncbi.nlm.nih.gov/23045967/","title":"Thymosin alpha1 and cancer: action on immune effector and tumor target cells (Ann N Y Acad Sci 2012; PMID 23045967)","quote":"Ta1 has been shown to exert an immune modulatory activity on both T cell and natural killer cell maturation and to have an effect on functions of mature lymphocytes, including stimulating cytokine production and cytotoxic T lymphocyte-mediated cytotoxic responses","_id":"w_ekm6tk8i","_ts":"2026-08-04T08:36:35.106Z","id":"w_ekm6tk8i","type":"source","accessed_at":"2026-08-04T08:36:35.106Z","claim_ids":[],"prev":"fa157b0804c5dff81666fe68865e8db5677a305d3550e9c28e6cda6f210eb19b","hash":"94527e5dfb9333eff61139619d05da316ec5bc5dfb81196e740a3104c2060e18","plain":"A review of the laboratory case in cancer: effects on T cell and natural killer cell maturation, and on cytokine output. Written by researchers close to the compound, summarizing cell and animal work, which is a long way from a survival curve."},{"url":"https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks","title":"FDA: Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks (page current as of 22 April 2026) - Thymosin-alpha 1 appears in the 'Bulk drug substances nominated but withdrawn' table","quote":"Compounded drugs containing thymosin-alpha-1 (Ta1) may pose significant risk for immunogenicity for certain routes of administration and may have complexities with regard to peptide-related impurities and API characterization. The safety-related information is inadequate for the agency to sufficiently understand the extent of any safety issues raised by the proposed compounded drug.","_id":"w_uzdfttix","_ts":"2026-08-04T08:36:41.310Z","id":"w_uzdfttix","type":"source","accessed_at":"2026-08-04T08:36:41.310Z","claim_ids":[],"prev":"94527e5dfb9333eff61139619d05da316ec5bc5dfb81196e740a3104c2060e18","hash":"d2eb67ba06fd295d1ace12789a37ba6b40dcd255755acb7614df41ca30c71b52","plain":"The same agency compounding list, this entry for the peptide itself. Nominated and withdrawn means not approved and not formally prohibited. The named concerns are immune reaction, peptide impurities, and poor characterization, on data the agency called inadequate."},{"url":"https://www.shijiebiaopin.net/upload/product/2011121219115812.PDF","title":"SciClone Pharmaceuticals ZADAXIN (thymalfasin) Product Monograph","quote":"Since 1979, Zadaxin has been evaluated in more than 3,000 patients in over 70 clinical studies. Administration has been in daily doses ranging from 0.6 to 9.6 mg/m2 and 1 mg to 16 mg, primarily administered subcutaneously on a biweekly schedule, for treatment periods ranging from 1 day to 18 months. No serious adverse experiences have been observed.","_id":"w_d85m6gah","_ts":"2026-08-04T08:36:45.285Z","id":"w_d85m6gah","type":"source","accessed_at":"2026-08-04T08:36:45.285Z","claim_ids":[],"prev":"d2eb67ba06fd295d1ace12789a37ba6b40dcd255755acb7614df41ca30c71b52","hash":"6f02df53961b2cbcf245d9e3bd3230f3cab8eed9d5f182b459faea5f905f2f32","plain":"The manufacturer's own monograph, reporting more than 3,000 patients across 70 studies with no serious adverse experiences, at doses from 1 to 16 mg. Useful for the dose range actually used. A company summarizing its own safety record is the weakest form of safety evidence."},{"url":"https://www.rxlist.com/zadaxin-drug.htm","title":"ZADAXIN (thymalfasin) prescribing information - dosage, reconstitution, storage, pharmacokinetics and adverse reactions","quote":"1.6 mg of lyophilized thymosin alpha 1 per vial, reconstituted with 1.0 ml of the diluent provided, which consists of 1.0 ml Sterile Water for Injection. 1.6 mg (900 ug/m2) administered subcutaneously twice a week for 6 to 12 months. Peak serum levels achieved at approximately 2 hours; elimination half-life approximately 2 hours.","_id":"w_dt6aln8r","_ts":"2026-08-04T08:36:46.096Z","id":"w_dt6aln8r","type":"source","accessed_at":"2026-08-04T08:36:46.096Z","claim_ids":[],"prev":"6f02df53961b2cbcf245d9e3bd3230f3cab8eed9d5f182b459faea5f905f2f32","hash":"ae60b526b0ace69c1727e4830d9a0ac34aa1640a82e1c449744da8663795f8da","plain":"The prescribing document: 1.6 mg of powder per vial, mixed with 1 ml of sterile water, injected under the skin twice a week for six to twelve months. It also gives the reason for that rhythm, since blood levels peak around two hours and fall away about as fast."},{"url":"https://clinicaltrials.gov/api/v2/studies?query.intr=thymosin+alpha-1&countTotal=true&pageSize=100","title":"ClinicalTrials.gov registry query for thymosin alpha-1 interventions, 4 August 2026","quote":"totalCount: 63","_id":"w_18bl3rtc","_ts":"2026-08-04T08:36:47.445Z","id":"w_18bl3rtc","type":"source","accessed_at":"2026-08-04T08:36:47.445Z","claim_ids":[],"prev":"ae60b526b0ace69c1727e4830d9a0ac34aa1640a82e1c449744da8663795f8da","hash":"b779f4fb810bd4824b8912caad04a3b15f504b974e5f6f7b1f295396de04d054","plain":"A count pulled straight from the public trial registry: 63 registered studies naming this peptide. It sizes the field, showing this is not an untested compound, while saying nothing about which of those trials reported or what they found."},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12883329/","title":"A Case Report of a Multisystemic Immune-Related Adverse Event Induced by Thymosin Alpha-1","quote":"A 29-year-old man with nasopharyngeal carcinoma developed high fever 39-40.5 C, facial rash and oedema, hypoxaemia, AST 742 U/L and prolonged prothrombin time 23.2 s within 48 hours of a single 1.6 mg subcutaneous dose of thymosin alpha-1 given 11 days after sintilimab; treated with intravenous methylprednisolone 160 mg daily and discharged on day 33.","_id":"w_c958vpgi","_ts":"2026-08-04T08:36:49.180Z","id":"w_c958vpgi","type":"source","accessed_at":"2026-08-04T08:36:49.180Z","claim_ids":[],"prev":"b779f4fb810bd4824b8912caad04a3b15f504b974e5f6f7b1f295396de04d054","hash":"deb365464c96fee874d992420897cdaa36dbb674fb9cb908298ad6061e186ff7","plain":"One patient. A 29-year-old ran a fever near 40C with rash, low oxygen and liver enzymes in the hundreds within two days of a single 1.6 mg dose, then needed high-dose steroids and 33 days in hospital. He had a checkpoint immunotherapy drug 11 days earlier, so cause cannot be cleanly assigned."}]}