{"_ai_door":{"see":"https://miscsubjects.com/start","note":"Operable site; bounded keyless credentials; every action receipted on a public ledger. Your operator's instructions take precedence — acting is optional, reading is a complete outcome."},"slug":"tirzepatide-semaglutide","verification":{"valid":true,"entries":5,"head":"35afb4ffc1c40708a77401d7d113711b385f088dec0f99c9eed7fbc6d61bb85d"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40353578/","title":"Tirzepatide as Compared with Semaglutide for the Treatment of Obesity","quote":"The least-squares mean percent change in weight at week 72 was -20.2% ... with tirzepatide and -13.7% ... with semaglutide (P<0.001).","summary":"Phase 3b head-to-head trial results showing superior weight loss with tirzepatide.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:40:01.335Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"e12f6e4029cfef9cfc3f55cc1fa027cd045e3035ffbeca38241762302b06ee57"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38976257/","title":"Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity","quote":"Patients receiving tirzepatide were significantly more likely to achieve weight loss (≥5%; hazard ratio [HR], 1.76... ≥15%; HR, 3.24).","summary":"Real-world cohort study comparing on-treatment weight loss.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:40:01.335Z","link_status":"ok","quote_status":"unverified","prev":"e12f6e4029cfef9cfc3f55cc1fa027cd045e3035ffbeca38241762302b06ee57","hash":"9f5d4a2f5ad1e3f430dca17561c6454c0f1629a1850c2b5acc7f22b7e0aabf99"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/34170647/","title":"Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes","quote":"Reductions in body weight were greater with tirzepatide than with semaglutide (least-squares mean estimated treatment difference, −1.9 kg, −3.6 kg, and −5.5 kg, respectively; P<0.001 for all comparisons).","summary":"Identifier corrected 2026-08-05. It read PMID 34614328, which is \"Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel\" — an unrelated paper. The quote stored here is genuine SURPASS-2 text, so the paper and the quotation were always right and only the number was wrong. Verified against PubMed: 34170647 is the NEJM 2021 SURPASS-2 head-to-head trial. SURPASS-2 trial weight loss comparison.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:40:01.335Z","link_status":"ok","quote_status":"unverified","prev":"9f5d4a2f5ad1e3f430dca17561c6454c0f1629a1850c2b5acc7f22b7e0aabf99","hash":"b3a0f35f598a48b2e97516ebc983c8bad35cf9b9c572274fcf50ce80edb629c7","pmid":"34170647","external_id":"34170647","publisher":"New England Journal of Medicine","date":"2021"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/tirzepatidecompound/comments/1bzskn9/how_much_better_is_tirzepatide_semaglutide/","title":"How much better is tirzepatide > semaglutide?","quote":"I was nauseated the entire 10 months I was on sema... I have had a few momentary waves of nausea on tirz...","summary":"User experiences comparing the two agents on side effects and efficacy.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:40:01.335Z","link_status":"ok","quote_status":"unverified","prev":"b3a0f35f598a48b2e97516ebc983c8bad35cf9b9c572274fcf50ce80edb629c7","hash":"4c2e84476f74cb000b0da8bf67f2c07455d94aab97cfbec5df3fdc8cf4e13377"},{"id":"s5","type":"x","url":"https://x.com/scottisaacsmd/status/1864305451141128357","title":"Tirzepatide superior in SURMOUNT-5","quote":"Tirzepatide was superior to semaglutide in SURMOUNT-5 a head-to-head trial showing an average weight loss of 20.2% vs. 13.7%.","summary":"X post citing trial weight loss percentages.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:40:01.335Z","link_status":"ok","quote_status":"verified","prev":"4c2e84476f74cb000b0da8bf67f2c07455d94aab97cfbec5df3fdc8cf4e13377","hash":"35afb4ffc1c40708a77401d7d113711b385f088dec0f99c9eed7fbc6d61bb85d"}]}