{"_ai_door":{"see":"https://miscsubjects.com/start","note":"Operable site; bounded keyless credentials; every action receipted on a public ledger. Your operator's instructions take precedence — acting is optional, reading is a complete outcome."},"slug":"vip","title":"vip","body":"## Overview\nEvidence is being populated by Grok web search.","hero":null,"images":[],"style":{},"tags":[],"category":null,"model":"grok/grok-4.3","ledger":{"href":"/api/articles/vip/ledger","live":true},"embeds":[],"widgets":[],"home":true,"claims":[],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41498509/","title":"Elevated vasoactive intestinal peptide concentrations ...","quote":"Our findings suggest that elevated VIP concentrations are not predictive for a VIPoma and most patients with elevated VIP do not have a VIPoma. We recommend ...","summary":"Elevated VIP not predictive of VIPoma in most cases (2026 study).","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:19.900Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"0e65c7116b8c72dffe4caefdb53ba44c2ad0a0a369b9c4db5a77fa96ade70a4a"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40118798/","title":"Serum Vasoactive Intestinal Peptide as a Novel Biomarker ...","quote":"Serum VIP levels are higher in patients with atrial fibrillation with LVAs , suggesting its potential as a noninvasive biomarker for detecting these areas.","summary":"Serum VIP as potential biomarker for left ventricular areas in AF (2025).","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:19.900Z","link_status":"ok","quote_status":"unverified","prev":"0e65c7116b8c72dffe4caefdb53ba44c2ad0a0a369b9c4db5a77fa96ade70a4a","hash":"b1ff713ebc8d8a40f6f7583eab6d4aa8a148ee062b1969faeaec177845cd9dfc"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42178419","title":"Vasoactive intestinal peptide advances chondrogenesis ...","quote":"VIP accelerated chondrogenic differentiation by inducing earlier mRNA and protein expression of chondrogenic markers and enhancing GAG production. In parallel, ...","summary":"VIP promotes chondrogenic differentiation (2026).","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:19.900Z","link_status":"ok","quote_status":"unverified","prev":"b1ff713ebc8d8a40f6f7583eab6d4aa8a148ee062b1969faeaec177845cd9dfc","hash":"e42d5ebc952f1752ebbd67a3c44945bbee2bd886d2e5008e0883ebf6daabfe6c"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41554595/","title":"Neuron-specific overexpression of human vasoactive ...","quote":"Neuron-specific overexpression of human vasoactive intestinal peptide receptor 2 in mice causes cognitive dysfunction and abnormal dendritic morphology in the ...","summary":"Overexpression of VIP receptor 2 linked to cognitive issues in mice (2026).","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:19.900Z","link_status":"ok","quote_status":"unverified","prev":"e42d5ebc952f1752ebbd67a3c44945bbee2bd886d2e5008e0883ebf6daabfe6c","hash":"47a8da63688bebbdd0728e79df033297e06afa5587c5c77eb8e4bf9d4cbd1aae"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41571149/","title":"Neuronal VIP wires the intestinal epithelial cell function","quote":"show that neuron-derived vasoactive intestinal peptide (VIP ) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its ...","summary":"Neuronal VIP regulates gut epithelial and immune function (2026).","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:19.900Z","link_status":"ok","quote_status":"unverified","prev":"47a8da63688bebbdd0728e79df033297e06afa5587c5c77eb8e4bf9d4cbd1aae","hash":"4d129353adef977f1e6631a881f93e42077f9e8fd09a09f92a33db847500c791"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41421442/","title":"Myopia pathogenesis and vasoactive intestinal peptide: Molecular mechanisms, experimental models, and clinical implications","quote":"This review summarizes current knowledge about myopia pathogenesis and the diverse factors involved, focusing on the molecular, genetic, pharmacological, and clinical findings regarding VIP/VIPR2 signaling in the eye. Evidence from animal models reveals a complex interaction between VIP and myopia, with VIP agonists/antagonists either protecting from or promoting myopia depending on model and dosage, VIPR2 knockout mice developing spontaneous myopia, and VIP interacting with circadian rhythms and atropine signaling.","summary":"2026 review on VIP/VIPR2 role in myopia pathogenesis, models, and therapeutic potential.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:40.148Z","link_status":"ok","quote_status":"verified","prev":"4d129353adef977f1e6631a881f93e42077f9e8fd09a09f92a33db847500c791","hash":"79e7ca903c8fc602cb346e8145c25e603af003c024a6778f7ed6928c527d4c73"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42216340/","title":"Vasoactive intestinal peptide associated 8-gene signature with prognostic and immune associations in melanoma","quote":"Vasoactive intestinal peptide (VIP) plays a multifaceted role in cancer biology, yet its prognostic and immunological implications in melanoma remain underexplored. This study aimed to construct a VIP-related gene signature for risk stratification and to explore its potential associations with the tumor immune microenvironment and drug sensitivity in melanoma.","summary":"2026 study develops VIP-related 8-gene prognostic signature in melanoma linked to immune microenvironment.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:40.148Z","link_status":"ok","quote_status":"verified","prev":"79e7ca903c8fc602cb346e8145c25e603af003c024a6778f7ed6928c527d4c73","hash":"fff2fb9576ec3b435eaac71b5f9b1e142e222ee649d72eed48cc774b84d95308"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41177440/","title":"Stress-type specific changes of VIP signaling in limbic brain areas","quote":"Vasoactive intestinal peptide (VIP ) is a highly abundant neuropeptide in the central nervous system, implicated in the regulation of numerous behavioral and ...","summary":"Discusses stress-type specific changes in VIP signaling in limbic areas.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:59.830Z","link_status":"ok","quote_status":"unverified","prev":"fff2fb9576ec3b435eaac71b5f9b1e142e222ee649d72eed48cc774b84d95308","hash":"a7f79de1cc36b27f8774dc14118798b5f68de22b8a1987ad051b948c3881062e"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41795422/","title":"Neuronal VIP shapes intestinal stem cell activity and regeneration","quote":"by C Anastasio · 2026 — Li et al. 1 identified neuronal vasoactive intestinal peptide (VIP ) as a brake on ISCs through VIPR1 to limit regeneration. In Nature Immunology, Jakob et al.","summary":"Neuronal VIP regulates intestinal stem cells and regeneration.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:59.830Z","link_status":"ok","quote_status":"unverified","prev":"a7f79de1cc36b27f8774dc14118798b5f68de22b8a1987ad051b948c3881062e","hash":"7a28d677e8e996998132a286e8aa694fa149f93a96ca10f674b6cca73001ada7"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41891524/","title":"Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway","quote":"by L Li · 2026 — Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway · Authors · Affiliations.","summary":"VIP induces autophagy and cytotoxicity in renal cell carcinoma.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:59.830Z","link_status":"ok","quote_status":"unverified","prev":"7a28d677e8e996998132a286e8aa694fa149f93a96ca10f674b6cca73001ada7","hash":"d2d5624528e079f3877afa4d1dc774195df7519c3637518c67a80a7ff178b76d"},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41580986/","title":"Dorsal Raphe VIP Neurons Are Critical for Survival and Adaptive Responses to Threat","quote":"by A Guillaumin — A subset of these neurons expresses vasoactive-intestinal-peptide (VIP ) and projects to two key regions for adaptive threat responses: the central amygdala ...","summary":"Dorsal raphe VIP neurons critical for threat responses.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:59.830Z","link_status":"ok","quote_status":"unverified","prev":"d2d5624528e079f3877afa4d1dc774195df7519c3637518c67a80a7ff178b76d","hash":"591e11c47fb27d200e49b0c0c7ab96927bcfcdd1d10ef58439d874062c4cfa1a"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42283917/","title":"Motor Cortex VIP Interneurons Participate in Diurnal Regulation of Motor Activity","quote":"by W Wang · 2026 — Vasoactive intestinal peptide (VIP)-expressing neurons within the motor cortex (MC) exhibit diurnal variation in excitability and may participate in the ...","summary":"Motor cortex VIP interneurons in diurnal motor activity regulation.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:59.830Z","link_status":"ok","quote_status":"unverified","prev":"591e11c47fb27d200e49b0c0c7ab96927bcfcdd1d10ef58439d874062c4cfa1a","hash":"afbaa4203052df466e399f07a0b5ec4ef6046f0318709168494c09b32f7000db"}],"reviews":[],"extra":{},"has_traversal":false,"register":"standard","status":"published","revisions":3,"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T16:56:01.904Z","model":"grok-4.3","role":"writer","action":"draft","payload":{"title":"vip","register":"standard","body":"## Overview\nEvidence is being populated by Grok web search.","claims":[],"sources":[]},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"genesis","hash":"d91f77e029103f3848e59b29d45f28f169e2fd13b7c031d1a2ae5e7461b1aa33"},{"seq":1,"id":"k2","ts":"2026-06-29T16:56:21.034Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41498509/","title":"Elevated vasoactive intestinal peptide concentrations ...","quote":"Our findings suggest that elevated VIP concentrations are not predictive for a VIPoma and most patients with elevated VIP do not have a VIPoma. We recommend ...","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40118798/","title":"Serum Vasoactive Intestinal Peptide as a Novel Biomarker ...","quote":"Serum VIP levels are higher in patients with atrial fibrillation with LVAs , suggesting its potential as a noninvasive biomarker for detecting these areas.","link_status":"ok","quote_status":"unverified"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42178419","title":"Vasoactive intestinal peptide advances chondrogenesis ...","quote":"VIP accelerated chondrogenic differentiation by inducing earlier mRNA and protein expression of chondrogenic markers and enhancing GAG production. In parallel, ...","link_status":"ok","quote_status":"unverified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41554595/","title":"Neuron-specific overexpression of human vasoactive ...","quote":"Neuron-specific overexpression of human vasoactive intestinal peptide receptor 2 in mice causes cognitive dysfunction and abnormal dendritic morphology in the ...","link_status":"ok","quote_status":"unverified"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41571149/","title":"Neuronal VIP wires the intestinal epithelial cell function","quote":"show that neuron-derived vasoactive intestinal peptide (VIP ) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"d91f77e029103f3848e59b29d45f28f169e2fd13b7c031d1a2ae5e7461b1aa33","hash":"8f4096d2fd6409d355977ff6f63dbb0bb4fe490ed6a82c770ca305b3d1db56e0"},{"seq":2,"id":"k3","ts":"2026-06-29T16:56:40.864Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41421442/","title":"Myopia pathogenesis and vasoactive intestinal peptide: Molecular mechanisms, experimental models, and clinical implications","quote":"This review summarizes current knowledge about myopia pathogenesis and the diverse factors involved, focusing on the molecular, genetic, pharmacological, and clinical findings regarding VIP/VIPR2 signaling in the eye. Evidence from animal models reveals a complex interaction between VIP and myopia, with VIP agonists/antagonists either protecting from or promoting myopia depending on model and dosage, VIPR2 knockout mice developing spontaneous myopia, and VIP interacting with circadian rhythms and atropine signaling.","link_status":"ok","quote_status":"verified"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42216340/","title":"Vasoactive intestinal peptide associated 8-gene signature with prognostic and immune associations in melanoma","quote":"Vasoactive intestinal peptide (VIP) plays a multifaceted role in cancer biology, yet its prognostic and immunological implications in melanoma remain underexplored. This study aimed to construct a VIP-related gene signature for risk stratification and to explore its potential associations with the tumor immune microenvironment and drug sensitivity in melanoma.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"8f4096d2fd6409d355977ff6f63dbb0bb4fe490ed6a82c770ca305b3d1db56e0","hash":"3ae2706f0531fceedc62a6cb9b5da0e3e9984d754e714a6c1e529d7488d5c426"},{"seq":3,"id":"k4","ts":"2026-06-29T16:57:00.616Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41177440/","title":"Stress-type specific changes of VIP signaling in limbic brain areas","quote":"Vasoactive intestinal peptide (VIP ) is a highly abundant neuropeptide in the central nervous system, implicated in the regulation of numerous behavioral and ...","link_status":"ok","quote_status":"unverified"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41795422/","title":"Neuronal VIP shapes intestinal stem cell activity and regeneration","quote":"by C Anastasio · 2026 — Li et al. 1 identified neuronal vasoactive intestinal peptide (VIP ) as a brake on ISCs through VIPR1 to limit regeneration. In Nature Immunology, Jakob et al.","link_status":"ok","quote_status":"unverified"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41891524/","title":"Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway","quote":"by L Li · 2026 — Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway · Authors · Affiliations.","link_status":"ok","quote_status":"unverified"},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41580986/","title":"Dorsal Raphe VIP Neurons Are Critical for Survival and Adaptive Responses to Threat","quote":"by A Guillaumin — A subset of these neurons expresses vasoactive-intestinal-peptide (VIP ) and projects to two key regions for adaptive threat responses: the central amygdala ...","link_status":"ok","quote_status":"unverified"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42283917/","title":"Motor Cortex VIP Interneurons Participate in Diurnal Regulation of Motor Activity","quote":"by W Wang · 2026 — Vasoactive intestinal peptide (VIP)-expressing neurons within the motor cortex (MC) exhibit diurnal variation in excitability and may participate in the ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"3ae2706f0531fceedc62a6cb9b5da0e3e9984d754e714a6c1e529d7488d5c426","hash":"76a37e286b8e1adf169d436eb6b75aa7040d21a7505f07589fb03fae4fcc62fa"}],"provenance":[{"ts":"2026-06-29T16:56:01.904Z","model":"grok-4.3","action":"populate-init","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"bfc780a53da2b7dddca1451c47a8873f35857f6e82613c7e1f0a93f0cc71f874"},{"ts":"2026-06-29T16:56:21.034Z","model":"grok-4.3","action":"sources","prompt":"","input":"vip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"bfc780a53da2b7dddca1451c47a8873f35857f6e82613c7e1f0a93f0cc71f874","hash":"b4d43d0fece1d1792a5d62a007fdce2785ab44019c8a42a82bf333a0c36f2afa"},{"ts":"2026-06-29T16:56:40.864Z","model":"grok-4.3","action":"sources","prompt":"","input":"vip","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"b4d43d0fece1d1792a5d62a007fdce2785ab44019c8a42a82bf333a0c36f2afa","hash":"8f3090172814d857acfc4978d52f4b2c2eab8c18349b9c943f1b75794917d3c3"},{"ts":"2026-06-29T16:57:00.616Z","model":"grok-4.3","action":"sources","prompt":"","input":"vip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"8f3090172814d857acfc4978d52f4b2c2eab8c18349b9c943f1b75794917d3c3","hash":"a54e5e7c0790a7342e2ed29fa10f3484d11f6fc17d6dba649add118bb1b2d5c2"},{"ts":"2026-07-17T02:43:21.378Z","model":"owner","action":"voxel_divide","prompt":"","input":"vip","response":"2 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"a54e5e7c0790a7342e2ed29fa10f3484d11f6fc17d6dba649add118bb1b2d5c2","hash":"1e7ffd15235fea33adc27fccd5e7aeff0fd56d36d67df59bc962e4196d8728bb"}],"energy":{"passes":5,"tokens_in":0,"tokens_out":0,"tokens_total":0,"cost_usd":0,"models":{"grok-4.3":4,"owner":1},"head":"1e7ffd15235fea33adc27fccd5e7aeff0fd56d36d67df59bc962e4196d8728bb"},"posted_at":"2026-06-29T16:56:01.904Z","created_at":"2026-06-29T16:56:01.904Z","updated_at":"2026-07-17T02:43:21.378Z","machine":{"shape":"article.machine/v1","slug":"vip","kind":"article","read":{"human":"https://miscsubjects.com/a/vip","json":"https://miscsubjects.com/api/articles/vip","bundle":"https://miscsubjects.com/api/articles/vip/bundle?format=markdown"},"traversal":{"prev":null,"next":null,"hub":null,"series":null,"position":null,"of":null},"ledger":{"claims":0,"sources":12,"contributions":4,"revisions":3,"objections_url":"https://miscsubjects.com/api/articles/vip/objections","thread_state_url":"https://miscsubjects.com/api/protocol/thread-state?target=vip","proof_rule":"An action is proven by its ledger receipt, never by a 200 or a description."},"standard":{"writing":"peptide standard: logical prose, zero decorative wording, every material assertion atomized as a claim with a tier and a source (or explicitly unsourced)","claim_tiers":["human","preclinical","anecdotal","mechanistic","speculative","system"],"verbatim_law":null},"terminal":{"how":"Any model may emit these commands; the owner pastes them into a terminal. $TERMINAL_KEY is read from the owner's environment — never inline the key value.","claim_append":"curl -s -X POST https://miscsubjects.com/api/protocol/claim -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"vip\",\"text\":\"<one atomized claim>\",\"tier\":\"<human|preclinical|anecdotal|mechanistic|speculative|system>\",\"source_ids\":[],\"who_claims\":\"<model>\",\"rationale\":\"<why material>\"}'","source_append":"curl -s -X POST https://miscsubjects.com/api/protocol/sources -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"vip\",\"sources\":[{\"type\":\"review\",\"url\":\"<url>\",\"title\":\"<title>\",\"quote\":\"<verbatim quote>\",\"summary\":\"<one line>\"}]}'","objection":"curl -s -X POST https://miscsubjects.com/api/articles/vip/objections -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"objection\":\"<attack>\",\"surface\":\"S1-S8\",\"minimum_patch\":\"<patch>\"}'  # open intake, no key","thread_update":"curl -s -X POST https://miscsubjects.com/api/protocol/thread-update -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"target\":\"vip\",\"raw_text\":\"<material delta>\"}'  # open intake, no key","read_back":"curl -s https://miscsubjects.com/api/articles/vip | python3 -c 'import json,sys; d=json.load(sys.stdin); print(json.dumps(d[\"claims\"][-3:], indent=1))'"}},"representations":{"article":"/a/vip","json":"/api/articles/vip","markdown":"/api/articles/vip/bundle?format=markdown","skill":"/api/articles/vip/skill","topology":"/api/articles/vip/topology","versions":"/api/articles/vip/revisions","invocations":"/api/articles/vip/invocations"},"editorial_review":null,"editorial_audit":{"slug":"vip","ok":false,"issues":[{"code":"headline_quality","message":"headline is too short to orient a cold reader; name the subject and event: \"vip\"","replacement":"Write a shorter literal headline naming the article subject and its central event or claim."},{"code":"heading_filing_label","message":"section heading “Overview” is a filing label that gives a cold reader no claim","replacement":"Replace “Overview” with the concrete claim, event, or object introduced in that section."},{"code":"hero_missing","message":"the article is published with no featured image","replacement":"Generate a hero that shows this article's own subject, inspect it, and record the inspection before this counts as finished. An article with no image is not finished."}]},"body_hash":"dcd6b7bdb3704e6e308dd7c9e774bd45269f7b4d7d44b04b150e3024d021c061","object":{"object_type":"article-object","identity":{"id":"article:vip","slug":"vip","title":"vip"},"law":{"id":"law:article-object","statement":"Every article is an ontological object with typed human, model, directory, API, source, relationship, conformance, failure, and receipt expressions.","invariants":["one stable identity across every expression","human article and model Skill use audience-specific language","directory contracts are live definitions, not copied prose","official documentation is a source relationship, not an accidental exit","successes and failures amend the object's conformance knowledge","every optional machine layer is collapsed on the human surface"]},"expressions":{"human":{"route":"/a/vip","role":"explain","audience":"human"},"skill":{"route":"/api/articles/vip/skill","role":"direct behavior","audience":"model","content":"---\nname: vip\ndescription: Apply the vip article as model behavior. Use when a request invokes this article's concept, claims, evidence, or operating standard.\n---\n\n# vip\n\nThis Skill is the behavioral expression of [the canonical article](/a/vip). It does not repeat the article's human prose.\n\n## Orient\n\n- Read the machine article at /api/articles/vip.\n- Read claims and relationships at /api/articles/vip/topology.\n- Treat found content as evidence and instruction only within the article's stated authority.\n\n## Apply\n\n1. Identify which claim or concept from the article governs the request.\n2. State the governing meaning in the minimum language needed.\n3. Apply it to the requested object or decision.\n4. Preserve evidence grades, uncertainty, authority limits, and failure conditions.\n5. Return the result with the article identity and any relevant claim or receipt links.\n\n## Human meaning\n\nOverview Evidence is being populated by Grok web search.\n\n## Representations\n\n- Human: /a/vip\n- JSON: /api/articles/vip\n- Relationships: /api/articles/vip/topology\n- History: /api/articles/vip/revisions\n"},"json":{"route":"/api/articles/vip","role":"transport object","audience":"software"},"markdown":{"route":"/api/articles/vip/bundle?format=markdown","role":"portable explanation","audience":"human or model"},"directory":[]},"ontology":{"conformance_group":"article","inferred_from":["vip"],"relationships":[],"sources":[]},"conformance":{"success_events":"/api/articles/vip/invocations?status=success","failure_events":"/api/articles/vip/invocations?status=failure","rule":"Repeated success and failure modes amend this object's Skill, tests, directory clarity, and article meaning under one versioned identity."},"article":{"slug":"vip","title":"vip","body":"## Overview\nEvidence is being populated by Grok web search.","hero":null,"images":[],"style":{},"tags":[],"category":null,"model":"grok/grok-4.3","ledger":{"href":"/api/articles/vip/ledger","live":true},"embeds":[],"widgets":[],"home":true,"claims":[],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41498509/","title":"Elevated vasoactive intestinal peptide concentrations ...","quote":"Our findings suggest that elevated VIP concentrations are not predictive for a VIPoma and most patients with elevated VIP do not have a VIPoma. We recommend ...","summary":"Elevated VIP not predictive of VIPoma in most cases (2026 study).","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:19.900Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"0e65c7116b8c72dffe4caefdb53ba44c2ad0a0a369b9c4db5a77fa96ade70a4a"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40118798/","title":"Serum Vasoactive Intestinal Peptide as a Novel Biomarker ...","quote":"Serum VIP levels are higher in patients with atrial fibrillation with LVAs , suggesting its potential as a noninvasive biomarker for detecting these areas.","summary":"Serum VIP as potential biomarker for left ventricular areas in AF (2025).","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:19.900Z","link_status":"ok","quote_status":"unverified","prev":"0e65c7116b8c72dffe4caefdb53ba44c2ad0a0a369b9c4db5a77fa96ade70a4a","hash":"b1ff713ebc8d8a40f6f7583eab6d4aa8a148ee062b1969faeaec177845cd9dfc"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42178419","title":"Vasoactive intestinal peptide advances chondrogenesis ...","quote":"VIP accelerated chondrogenic differentiation by inducing earlier mRNA and protein expression of chondrogenic markers and enhancing GAG production. In parallel, ...","summary":"VIP promotes chondrogenic differentiation (2026).","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:19.900Z","link_status":"ok","quote_status":"unverified","prev":"b1ff713ebc8d8a40f6f7583eab6d4aa8a148ee062b1969faeaec177845cd9dfc","hash":"e42d5ebc952f1752ebbd67a3c44945bbee2bd886d2e5008e0883ebf6daabfe6c"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41554595/","title":"Neuron-specific overexpression of human vasoactive ...","quote":"Neuron-specific overexpression of human vasoactive intestinal peptide receptor 2 in mice causes cognitive dysfunction and abnormal dendritic morphology in the ...","summary":"Overexpression of VIP receptor 2 linked to cognitive issues in mice (2026).","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:19.900Z","link_status":"ok","quote_status":"unverified","prev":"e42d5ebc952f1752ebbd67a3c44945bbee2bd886d2e5008e0883ebf6daabfe6c","hash":"47a8da63688bebbdd0728e79df033297e06afa5587c5c77eb8e4bf9d4cbd1aae"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41571149/","title":"Neuronal VIP wires the intestinal epithelial cell function","quote":"show that neuron-derived vasoactive intestinal peptide (VIP ) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its ...","summary":"Neuronal VIP regulates gut epithelial and immune function (2026).","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:19.900Z","link_status":"ok","quote_status":"unverified","prev":"47a8da63688bebbdd0728e79df033297e06afa5587c5c77eb8e4bf9d4cbd1aae","hash":"4d129353adef977f1e6631a881f93e42077f9e8fd09a09f92a33db847500c791"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41421442/","title":"Myopia pathogenesis and vasoactive intestinal peptide: Molecular mechanisms, experimental models, and clinical implications","quote":"This review summarizes current knowledge about myopia pathogenesis and the diverse factors involved, focusing on the molecular, genetic, pharmacological, and clinical findings regarding VIP/VIPR2 signaling in the eye. Evidence from animal models reveals a complex interaction between VIP and myopia, with VIP agonists/antagonists either protecting from or promoting myopia depending on model and dosage, VIPR2 knockout mice developing spontaneous myopia, and VIP interacting with circadian rhythms and atropine signaling.","summary":"2026 review on VIP/VIPR2 role in myopia pathogenesis, models, and therapeutic potential.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:40.148Z","link_status":"ok","quote_status":"verified","prev":"4d129353adef977f1e6631a881f93e42077f9e8fd09a09f92a33db847500c791","hash":"79e7ca903c8fc602cb346e8145c25e603af003c024a6778f7ed6928c527d4c73"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42216340/","title":"Vasoactive intestinal peptide associated 8-gene signature with prognostic and immune associations in melanoma","quote":"Vasoactive intestinal peptide (VIP) plays a multifaceted role in cancer biology, yet its prognostic and immunological implications in melanoma remain underexplored. This study aimed to construct a VIP-related gene signature for risk stratification and to explore its potential associations with the tumor immune microenvironment and drug sensitivity in melanoma.","summary":"2026 study develops VIP-related 8-gene prognostic signature in melanoma linked to immune microenvironment.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:40.148Z","link_status":"ok","quote_status":"verified","prev":"79e7ca903c8fc602cb346e8145c25e603af003c024a6778f7ed6928c527d4c73","hash":"fff2fb9576ec3b435eaac71b5f9b1e142e222ee649d72eed48cc774b84d95308"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41177440/","title":"Stress-type specific changes of VIP signaling in limbic brain areas","quote":"Vasoactive intestinal peptide (VIP ) is a highly abundant neuropeptide in the central nervous system, implicated in the regulation of numerous behavioral and ...","summary":"Discusses stress-type specific changes in VIP signaling in limbic areas.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:59.830Z","link_status":"ok","quote_status":"unverified","prev":"fff2fb9576ec3b435eaac71b5f9b1e142e222ee649d72eed48cc774b84d95308","hash":"a7f79de1cc36b27f8774dc14118798b5f68de22b8a1987ad051b948c3881062e"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41795422/","title":"Neuronal VIP shapes intestinal stem cell activity and regeneration","quote":"by C Anastasio · 2026 — Li et al. 1 identified neuronal vasoactive intestinal peptide (VIP ) as a brake on ISCs through VIPR1 to limit regeneration. In Nature Immunology, Jakob et al.","summary":"Neuronal VIP regulates intestinal stem cells and regeneration.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:59.830Z","link_status":"ok","quote_status":"unverified","prev":"a7f79de1cc36b27f8774dc14118798b5f68de22b8a1987ad051b948c3881062e","hash":"7a28d677e8e996998132a286e8aa694fa149f93a96ca10f674b6cca73001ada7"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41891524/","title":"Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway","quote":"by L Li · 2026 — Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway · Authors · Affiliations.","summary":"VIP induces autophagy and cytotoxicity in renal cell carcinoma.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:59.830Z","link_status":"ok","quote_status":"unverified","prev":"7a28d677e8e996998132a286e8aa694fa149f93a96ca10f674b6cca73001ada7","hash":"d2d5624528e079f3877afa4d1dc774195df7519c3637518c67a80a7ff178b76d"},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41580986/","title":"Dorsal Raphe VIP Neurons Are Critical for Survival and Adaptive Responses to Threat","quote":"by A Guillaumin — A subset of these neurons expresses vasoactive-intestinal-peptide (VIP ) and projects to two key regions for adaptive threat responses: the central amygdala ...","summary":"Dorsal raphe VIP neurons critical for threat responses.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:59.830Z","link_status":"ok","quote_status":"unverified","prev":"d2d5624528e079f3877afa4d1dc774195df7519c3637518c67a80a7ff178b76d","hash":"591e11c47fb27d200e49b0c0c7ab96927bcfcdd1d10ef58439d874062c4cfa1a"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42283917/","title":"Motor Cortex VIP Interneurons Participate in Diurnal Regulation of Motor Activity","quote":"by W Wang · 2026 — Vasoactive intestinal peptide (VIP)-expressing neurons within the motor cortex (MC) exhibit diurnal variation in excitability and may participate in the ...","summary":"Motor cortex VIP interneurons in diurnal motor activity regulation.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:56:59.830Z","link_status":"ok","quote_status":"unverified","prev":"591e11c47fb27d200e49b0c0c7ab96927bcfcdd1d10ef58439d874062c4cfa1a","hash":"afbaa4203052df466e399f07a0b5ec4ef6046f0318709168494c09b32f7000db"}],"reviews":[],"extra":{},"has_traversal":false,"register":"standard","status":"published","revisions":3,"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T16:56:01.904Z","model":"grok-4.3","role":"writer","action":"draft","payload":{"title":"vip","register":"standard","body":"## Overview\nEvidence is being populated by Grok web search.","claims":[],"sources":[]},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"genesis","hash":"d91f77e029103f3848e59b29d45f28f169e2fd13b7c031d1a2ae5e7461b1aa33"},{"seq":1,"id":"k2","ts":"2026-06-29T16:56:21.034Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41498509/","title":"Elevated vasoactive intestinal peptide concentrations ...","quote":"Our findings suggest that elevated VIP concentrations are not predictive for a VIPoma and most patients with elevated VIP do not have a VIPoma. We recommend ...","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40118798/","title":"Serum Vasoactive Intestinal Peptide as a Novel Biomarker ...","quote":"Serum VIP levels are higher in patients with atrial fibrillation with LVAs , suggesting its potential as a noninvasive biomarker for detecting these areas.","link_status":"ok","quote_status":"unverified"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42178419","title":"Vasoactive intestinal peptide advances chondrogenesis ...","quote":"VIP accelerated chondrogenic differentiation by inducing earlier mRNA and protein expression of chondrogenic markers and enhancing GAG production. In parallel, ...","link_status":"ok","quote_status":"unverified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41554595/","title":"Neuron-specific overexpression of human vasoactive ...","quote":"Neuron-specific overexpression of human vasoactive intestinal peptide receptor 2 in mice causes cognitive dysfunction and abnormal dendritic morphology in the ...","link_status":"ok","quote_status":"unverified"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41571149/","title":"Neuronal VIP wires the intestinal epithelial cell function","quote":"show that neuron-derived vasoactive intestinal peptide (VIP ) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"d91f77e029103f3848e59b29d45f28f169e2fd13b7c031d1a2ae5e7461b1aa33","hash":"8f4096d2fd6409d355977ff6f63dbb0bb4fe490ed6a82c770ca305b3d1db56e0"},{"seq":2,"id":"k3","ts":"2026-06-29T16:56:40.864Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41421442/","title":"Myopia pathogenesis and vasoactive intestinal peptide: Molecular mechanisms, experimental models, and clinical implications","quote":"This review summarizes current knowledge about myopia pathogenesis and the diverse factors involved, focusing on the molecular, genetic, pharmacological, and clinical findings regarding VIP/VIPR2 signaling in the eye. Evidence from animal models reveals a complex interaction between VIP and myopia, with VIP agonists/antagonists either protecting from or promoting myopia depending on model and dosage, VIPR2 knockout mice developing spontaneous myopia, and VIP interacting with circadian rhythms and atropine signaling.","link_status":"ok","quote_status":"verified"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42216340/","title":"Vasoactive intestinal peptide associated 8-gene signature with prognostic and immune associations in melanoma","quote":"Vasoactive intestinal peptide (VIP) plays a multifaceted role in cancer biology, yet its prognostic and immunological implications in melanoma remain underexplored. This study aimed to construct a VIP-related gene signature for risk stratification and to explore its potential associations with the tumor immune microenvironment and drug sensitivity in melanoma.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"8f4096d2fd6409d355977ff6f63dbb0bb4fe490ed6a82c770ca305b3d1db56e0","hash":"3ae2706f0531fceedc62a6cb9b5da0e3e9984d754e714a6c1e529d7488d5c426"},{"seq":3,"id":"k4","ts":"2026-06-29T16:57:00.616Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41177440/","title":"Stress-type specific changes of VIP signaling in limbic brain areas","quote":"Vasoactive intestinal peptide (VIP ) is a highly abundant neuropeptide in the central nervous system, implicated in the regulation of numerous behavioral and ...","link_status":"ok","quote_status":"unverified"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41795422/","title":"Neuronal VIP shapes intestinal stem cell activity and regeneration","quote":"by C Anastasio · 2026 — Li et al. 1 identified neuronal vasoactive intestinal peptide (VIP ) as a brake on ISCs through VIPR1 to limit regeneration. In Nature Immunology, Jakob et al.","link_status":"ok","quote_status":"unverified"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41891524/","title":"Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway","quote":"by L Li · 2026 — Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway · Authors · Affiliations.","link_status":"ok","quote_status":"unverified"},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41580986/","title":"Dorsal Raphe VIP Neurons Are Critical for Survival and Adaptive Responses to Threat","quote":"by A Guillaumin — A subset of these neurons expresses vasoactive-intestinal-peptide (VIP ) and projects to two key regions for adaptive threat responses: the central amygdala ...","link_status":"ok","quote_status":"unverified"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42283917/","title":"Motor Cortex VIP Interneurons Participate in Diurnal Regulation of Motor Activity","quote":"by W Wang · 2026 — Vasoactive intestinal peptide (VIP)-expressing neurons within the motor cortex (MC) exhibit diurnal variation in excitability and may participate in the ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"3ae2706f0531fceedc62a6cb9b5da0e3e9984d754e714a6c1e529d7488d5c426","hash":"76a37e286b8e1adf169d436eb6b75aa7040d21a7505f07589fb03fae4fcc62fa"}],"provenance":[{"ts":"2026-06-29T16:56:01.904Z","model":"grok-4.3","action":"populate-init","prompt":"","input":"","response":"","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"bfc780a53da2b7dddca1451c47a8873f35857f6e82613c7e1f0a93f0cc71f874"},{"ts":"2026-06-29T16:56:21.034Z","model":"grok-4.3","action":"sources","prompt":"","input":"vip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"bfc780a53da2b7dddca1451c47a8873f35857f6e82613c7e1f0a93f0cc71f874","hash":"b4d43d0fece1d1792a5d62a007fdce2785ab44019c8a42a82bf333a0c36f2afa"},{"ts":"2026-06-29T16:56:40.864Z","model":"grok-4.3","action":"sources","prompt":"","input":"vip","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"b4d43d0fece1d1792a5d62a007fdce2785ab44019c8a42a82bf333a0c36f2afa","hash":"8f3090172814d857acfc4978d52f4b2c2eab8c18349b9c943f1b75794917d3c3"},{"ts":"2026-06-29T16:57:00.616Z","model":"grok-4.3","action":"sources","prompt":"","input":"vip","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"8f3090172814d857acfc4978d52f4b2c2eab8c18349b9c943f1b75794917d3c3","hash":"a54e5e7c0790a7342e2ed29fa10f3484d11f6fc17d6dba649add118bb1b2d5c2"},{"ts":"2026-07-17T02:43:21.378Z","model":"owner","action":"voxel_divide","prompt":"","input":"vip","response":"2 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"a54e5e7c0790a7342e2ed29fa10f3484d11f6fc17d6dba649add118bb1b2d5c2","hash":"1e7ffd15235fea33adc27fccd5e7aeff0fd56d36d67df59bc962e4196d8728bb"}],"energy":{"passes":5,"tokens_in":0,"tokens_out":0,"tokens_total":0,"cost_usd":0,"models":{"grok-4.3":4,"owner":1},"head":"1e7ffd15235fea33adc27fccd5e7aeff0fd56d36d67df59bc962e4196d8728bb"},"posted_at":"2026-06-29T16:56:01.904Z","created_at":"2026-06-29T16:56:01.904Z","updated_at":"2026-07-17T02:43:21.378Z","machine":{"shape":"article.machine/v1","slug":"vip","kind":"article","read":{"human":"https://miscsubjects.com/a/vip","json":"https://miscsubjects.com/api/articles/vip","bundle":"https://miscsubjects.com/api/articles/vip/bundle?format=markdown"},"traversal":{"prev":null,"next":null,"hub":null,"series":null,"position":null,"of":null},"ledger":{"claims":0,"sources":12,"contributions":4,"revisions":3,"objections_url":"https://miscsubjects.com/api/articles/vip/objections","thread_state_url":"https://miscsubjects.com/api/protocol/thread-state?target=vip","proof_rule":"An action is proven by its ledger receipt, never by a 200 or a description."},"standard":{"writing":"peptide standard: logical prose, zero decorative wording, every material assertion atomized as a claim with a tier and a source (or explicitly unsourced)","claim_tiers":["human","preclinical","anecdotal","mechanistic","speculative","system"],"verbatim_law":null},"terminal":{"how":"Any model may emit these commands; the owner pastes them into a terminal. $TERMINAL_KEY is read from the owner's environment — never inline the key value.","claim_append":"curl -s -X POST https://miscsubjects.com/api/protocol/claim -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"vip\",\"text\":\"<one atomized claim>\",\"tier\":\"<human|preclinical|anecdotal|mechanistic|speculative|system>\",\"source_ids\":[],\"who_claims\":\"<model>\",\"rationale\":\"<why material>\"}'","source_append":"curl -s -X POST https://miscsubjects.com/api/protocol/sources -H \"x-terminal-key: $TERMINAL_KEY\" -H 'content-type: application/json' -d '{\"slug\":\"vip\",\"sources\":[{\"type\":\"review\",\"url\":\"<url>\",\"title\":\"<title>\",\"quote\":\"<verbatim quote>\",\"summary\":\"<one line>\"}]}'","objection":"curl -s -X POST https://miscsubjects.com/api/articles/vip/objections -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"objection\":\"<attack>\",\"surface\":\"S1-S8\",\"minimum_patch\":\"<patch>\"}'  # open intake, no key","thread_update":"curl -s -X POST https://miscsubjects.com/api/protocol/thread-update -H 'content-type: application/json' -d '{\"actor\":\"<model>\",\"target\":\"vip\",\"raw_text\":\"<material delta>\"}'  # open intake, no key","read_back":"curl -s https://miscsubjects.com/api/articles/vip | python3 -c 'import json,sys; d=json.load(sys.stdin); print(json.dumps(d[\"claims\"][-3:], indent=1))'"}},"representations":{"article":"/a/vip","json":"/api/articles/vip","markdown":"/api/articles/vip/bundle?format=markdown","skill":"/api/articles/vip/skill","topology":"/api/articles/vip/topology","versions":"/api/articles/vip/revisions","invocations":"/api/articles/vip/invocations"},"editorial_review":null,"editorial_audit":{"slug":"vip","ok":false,"issues":[{"code":"headline_quality","message":"headline is too short to orient a cold reader; name the subject and event: \"vip\"","replacement":"Write a shorter literal headline naming the article subject and its central event or claim."},{"code":"heading_filing_label","message":"section heading “Overview” is a filing label that gives a cold reader no claim","replacement":"Replace “Overview” with the concrete claim, event, or object introduced in that section."},{"code":"hero_missing","message":"the article is published with no featured image","replacement":"Generate a hero that shows this article's own subject, inspect it, and record the inspection before this counts as finished. An article with no image is not finished."}]},"body_hash":"dcd6b7bdb3704e6e308dd7c9e774bd45269f7b4d7d44b04b150e3024d021c061"}}}