Collection

Compound

5-amino-1MQ blocks the enzyme that throws away vitamin B3, and three currencies move at once

5-amino-1MQ blocks an enzyme that sits at a junction between three different things your cells need: the molecule that carries energy transactions, the molecule that donates methyl groups, and a set of small compounds called polyamines.

Compound

ATX-304 activates AMPK directly, and is the only compound in this catalogue tested in patients

ATX-304 is the only compound in this part of the catalogue that has been given to patients in a published clinical trial. That single fact separates it from almost everything sold beside it, and it is the reason to read about it

Compound

SLU-PP-332 is a chemical tool that switches on the endurance-training programme in muscle

SLU-PP-332 is a small molecule that turns on a genetic programme normally switched on by hard aerobic exercise. In mice it does roughly what a run does to muscle. It has never been given to a human being in a published study, and it was

Compound

Tesofensine produced the best weight-loss number of its era, and never became a medicine

Tesofensine is a pill that was tested for weight loss, produced the largest result any obesity drug had produced at the time, and then did not become a medicine. Understanding why is most of what there is to know about it. It was made by a

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