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mots c

Evidence is being populated by Grok web

Overview

Evidence is being populated by Grok web search.

References (8)
  1. MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity (MOTS-MET)“This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity.”
  2. MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner“We demonstrate, using two distinct transgenic mouse strains, that administration of MOTS-c augments muscle mitochondrial bioenergetic performance through reliance on both the transcriptional coactivator, Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), and cellular energy-sensing kinase, 5' adenosine monophosphate-activated protein kinase (AMPK).”
  3. Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss“Circulating MOTS-c levels were significantly higher in obese compared to lean individuals (273 ± 56 vs.”
  4. Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with type 2 diabetes mellitus“Recent research has identified the mitochondrial open reading frame of the 12S rRNA-c ( MOTS-c ) as a crucial mitochondrial peptide that significantly influences ...”
  5. Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes“Our findings suggest that mitochondrial-encoded MOTS-c regulate pancreatic islet cell senescence and that MOTS-c could act as a senotherapeutic agent to prevent pancreatic islet cell senescence and diabetes progression.”
  6. Exploring the therapeutic potential of MOTS-c in age-related macular degeneration“The MOTS-c peptide appears to enhance cellular metabolism and regulate gene expression, which could potentially provide therapeutic benefits in AMD.”
  7. Endurance training enhances skeletal muscle mitochondrial respiration by promoting MOTS-c secretion“More importantly, we found that endurance training may enhance the mitochondrial respiratory function of skeletal muscle by promoting the secretion of MOTS-c and activating the AMPK/PGC-1α pathway.”
  8. Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea“Recent research has identified the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) as a crucial mitochondrial peptide that significantly influences metabolic regulation, mimics the effects of exercise, and mitigates oxidative stress.”