Evidence review

BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary

#peptide#topic
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§SELF — this page explains the system
## §SELF — miscsubjects (paste without context)

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `human_page` — **Human article page**
Rendered article with claims, sources, copy widgets, ask prompts.
- **article slug:** `bpc-ara-post-surgical-nerve`
- **contains:** rendered article, copy widgets, claims, sources, ask prompts
- **how to use:** Use Copy for LLM or Copy system map — both paste without context.
- **read:** https://miscsubjects.com/a/bpc-ara-post-surgical-nerve

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/bpc-ara-post-surgical-nerve/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **bundle** — Paste-ready package: body + claims + sources + voxels + provenance + manifest + constitution. · https://miscsubjects.com/api/articles/bpc-ara-post-surgical-nerve/bundle?format=markdown
- **ask** — Answer only from topology; creates question_node with gaps and ingest_hint. · https://miscsubjects.com/api/articles/bpc-ara-post-surgical-nerve/prompts
- **topology** — Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER. · https://miscsubjects.com/api/articles/bpc-ara-post-surgical-nerve/topology

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

*Not medical advice. Tier-honest. Cite claim/source ids.*
What is known
  • ARA-290 treatment for 28 days in sarcoidosis patients with small fiber neuropathy improved neuropathic symptoms and increased corneal nerve fiber density.
  • Phase II trial data on ARA-290 improving neuropathic symptoms and nerve fibers in sarcoidosis; relevant to nerve damage repair (no BPC-157).
  • BPC-157 improved axonal regeneration, myelin thickness, and motor function in rat sciatic nerve transection models.
What is not known
  • Compares ARA-290 (nerve-specific) with BPC-157 (broad repair) for post-surgical nerve pain; supports potential stacking.
  • A medical resource characterizes ARA-290 as a tissue-protective peptide for nerve pain.

Regeneration vs degeneration — where this fits

The body breaks down tissue and builds it back at the same time. When breakdown outruns repair after surgery, nerve damage can stay. Most drugs reduce pain signals without fixing the nerve itself. BPC-157 and ARA-290 are studied for repair steps: new blood vessels, cell migration to the injury, and nerve fiber regrowth.

What it is

BPC-157 is a peptide studied in rat nerve injury models. ARA-290 is a peptide studied in human small fiber neuropathy trials. The ledger covers their separate use and reported stacking for post-surgical nerve damage.

How it works

BPC-157 is linked to angiogenesis and cytoprotection at the injury site in rat models. ARA-290 binds the innate repair receptor on nerve tissue and immune cells. Binding reduces neuroinflammation and supports nerve fiber regrowth.

Why it would work (logic chain)

If surgery cuts or stretches a nerve, then axons and myelin break down. If new blood vessels form and repair cells reach the site, then axons can regrow. If inflammation stays high, then regrowth slows. BPC-157 is proposed to aid the vessel and repair-cell steps. ARA-290 is proposed to lower inflammation and signal regrowth through the innate repair receptor. If both pathways run, then repair might increase.

Why people take it

People report post-surgical nerve pain or numbness that does not resolve. They look for options that target repair instead of only symptom relief.

How many people take it

Unknown. The ledger shows 8 Reddit posts, 5 X posts, and 3 other anecdote sources. No population count exists.

Evidence inventory

Sources total 28. Studies catalogued 11. Reddit posts 8. X posts 5. Other anecdote sources 3. Human claims 3. Preclinical claims 8. Anecdotal claims 17. Human data come from ARA-290 sarcoidosis trials. BPC-157 data are rat sciatic nerve transection studies. No human trial tests either compound or the combination for post-surgical nerve damage.

What scientists say

Rat study s1 showed BPC-157 improved axonal regeneration, myelin thickness, and motor function after sciatic nerve transection. Human trial s2 found ARA-290 improved SFNSL scores and increased corneal nerve fiber density after 28 days in sarcoidosis patients. Review s8 states ARA-290 reprograms a proinflammatory state toward healing. Review s18 states BPC-157 has the strongest preclinical evidence for peripheral nerve regeneration while ARA-290 has the strongest clinical evidence for small fiber neuropathy. No study tests the combination for post-surgical nerve damage.

What people say on Reddit

Reddit post s11 states: “I got a neuropathic pain due to nerve damage after surgery.” The user reports stacking BPC-157, TB-500, and ARA-290. Post s4 states the user added ARA-290 to BPC-157/TB-500 and saw symptom changes. Post s14 reports reduced nerve cracking after two months of ARA-290 but increased twitching after starting BPC-157. Post s15 states BPC-157 plus TB-500 produced no benefit during a flare, while ARA-290 gave roughly 50 percent improvement. Post s17 states ARA-290 gave temporary relief that lasted about two months after a one-month course. These are single-person reports, not controlled data.

What people say on X

X post s24 states ARA-290 at 2-4 mg daily paired with BPC-157 plus TB-500 for nerve repair and that results build over 3-4 weeks. Post s25 states ARA-290 reduces inflammation and supports nerve repair when paired with BPC-157. Post s26 states the stack of ARA-290, TB-500, and BPC-157 improved nerve function and mobility after soft-tissue healing. Post s27 states the user added ARA-290 to an existing TB-500 and BPC-157 cycle for nerve repair. These are individual accounts of perceived change.

What we do not know

No human clinical trial tests BPC-157 or the BPC-157 plus ARA-290 combination for post-surgical nerve damage. Long-term effects and safety in this setting are unknown. Species differences mean rat nerve data may not translate to humans.

Safety and limits

The ledger contains no safety data specific to post-surgical nerve damage use in humans. Evidence mix is mostly preclinical and anecdotal. Hash-chained sources verify integrity, not clinical truth. This is a research catalogue only.

Nerve damage / repair · condition map

Evidence map

Hover a node — its path lights up. Click to open the article.

Full map →
JumpARA-290 vs Gabapentin: Nerve Repair vs Symptom Masking · 17 humanARA-290: Nerve Repair Peptide · 13 humanARA-290 vs Gabapentin and Lyrica: Human Trial Data on Nerve Repair Ver… · 13 humanARA-290 for Post-Surgical Nerve Damage: Evidence Review · 9 human
Evidence · 49 sources · swipe →chain 419f6395a15c · verify chain · provenance
1 / 49

Key evidence

51 claims · tier-ranked · API
mechanistic
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
human
Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
system
BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.
anecdotal
Mentions ARA-290 specifically for post-operative nerve pain; comments reference stacking with other peptides including BPC-157 contexts.
sources: s5
anecdotal
Anecdotal report of ARA-290 stacked with BPC-157 aiding nerve repair and recovery.
sources: s25
anecdotal
User discusses potential benefits of ARA-290 for nerve regeneration/damage (drop foot), mentions BPC/TB stack positively for back pain.
sources: s28
anecdotal
Anecdotal reports from users on platforms like Reddit and Instagram suggest that BPC-157 and ARA-290 may help with post-surgical nerve pain, but these claims lack rigorous scientific validation.
sources: s4, s5
humanlow confidence
ARA-290 treatment for 28 days in sarcoidosis patients with small fiber neuropathy improved neuropathic symptoms and increased corneal nerve fiber density.
sources: s2
humanlow confidence
Compares ARA-290 (nerve-specific) with BPC-157 (broad repair) for post-surgical nerve pain; supports potential stacking.
sources: s6
humanlow confidence
Phase II trial data on ARA-290 improving neuropathic symptoms and nerve fibers in sarcoidosis; relevant to nerve damage repair (no BPC-157).
sources: s7
38 more ranked claims
human0.22
A medical resource characterizes ARA-290 as a tissue-protective peptide for nerve pain.
gemini-collaborator
This claim materializes information from an orphan source (s3) and provides context on how ARA-290 is described in some medical literature, enriching the 'who_claims_what' section.
sources: s3
human0.22low confidence
A review article discusses ARA-290 in the context of neuropathic pain and nerve repair.
gemini-collaborator
This claim materializes information from an orphan source (s6), indicating the scope of discussion for ARA-290 in a review, which is relevant to understanding the broader literature landscape.
sources: s6
preclinical0.22downweightedlow confidence
BPC-157 improved axonal regeneration, myelin thickness, and motor function in rat sciatic nerve transection models.
grok/4.3-populate
Documents rat-specific evidence for peripheral nerve healing separate from human data.
sources: s1
preclinical0.22low confidence
BPC-157 effects in rat nerve models involve angiogenesis and cytoprotection at the injury site.
grok/4.3-populate
Links given peptide definition to observed rat outcomes.
sources: s1
preclinical0.22low confidence
There is no information on the long-term effects or safety of using BPC-157 or ARA-290 for post-surgical nerve damage in humans.
kimi/moonshot-v1-8k
This claim addresses an explicit gap in the evidence regarding long-term safety and effects, which is crucial for understanding the complete picture of these treatments.
sources: s1
preclinical0.22low confidence
The efficacy and safety of BPC-157, or the combination of BPC-157 and ARA-290, specifically for post-surgical nerve damage in humans, remain unknown.
gemini-collaborator
This claim explicitly states a critical gap in human clinical evidence for the specific condition and combination, which is central to the ledger's topic. It uses existing sources to frame what has been studied to emphasize what has not.
sources: s1, s2, s7, s10
anecdotal0.22low confidence
User anecdotes on stacking ARA-290 with BPC-157 for neuropathy pain relief and nerve healing; reports of symptom improvement and flares.
grok/grok-4.3
Materialized from orphan source s4 by ledger repair
sources: s4
anecdotal0.22low confidence
User anecdote on stacking BPC-157, TB-500, and ARA-290 specifically for post-surgical neuropathic pain.
grok/grok-4.3
Materialized from orphan source s11 by ledger repair
sources: s11
anecdotal0.22low confidence
Mentions BPC-157 and ARA-290 peptide therapy for residual nerve pain after surgery.
grok/grok-4.3
Materialized from orphan source s13 by ledger repair
sources: s13
anecdotal0.22low confidence
User reports partial positive effect from 2 months ARA-290 (reduced nerve cracking and myoclonus) but negative reaction to BPC-157 (increased twitching), planning lower dose retry; context is SFN from toxic insult, considering stack for nerve repair.
grok/grok-4.3
Materialized from orphan source s14 by ledger repair
sources: s14
anecdotal0.22low confidence
User reports BPC-157 + TB-500 as ineffective/waste for neuropathy flare-up, leading to trying ARA-290 instead (which provided ~50% symptom improvement).
grok/grok-4.3
Materialized from orphan source s15 by ledger repair
sources: s15
anecdotal0.22low confidence
User mentions using ARA-290 (4mg cycle) after major back surgery in context of nerve/pain management and peptide stacking.
grok/grok-4.3
Materialized from orphan source s16 by ledger repair
sources: s16
anecdotal0.22low confidence
User reports ARA-290 provides temporary pain relief for neuropathy (relief lasting ~2 months after 1-month course) but requires ongoing/periodic use and is costly.
grok/grok-4.3
Materialized from orphan source s17 by ledger repair
sources: s17
anecdotal0.22low confidence
Reddit post (anecdotal/user guide) on ARA-290 for neuropathic pain and nerve regeneration, explicitly recommending stacking with BPC-157 for neuroprotection and tissue repair in nerve damage scenarios.
grok/grok-4.3
Materialized from orphan source s20 by ledger repair
sources: s20
anecdotal0.22low confidence
Reddit thread on BPC-157 for chronic/long-term nerve damage (feet pain), with context of neuropathy management.
grok/grok-4.3
Materialized from orphan source s23 by ledger repair
sources: s23
anecdotal0.22low confidence
User reports positive pairing of ARA-290 with BPC-157 (and TB-500) for nerve repair, with dosing and timeline advice.
grok/grok-4.3
Materialized from orphan source s24 by ledger repair
sources: s24
anecdotal0.22low confidence
User reports improved nerve function and mobility after stacking ARA-290 with BPC-157 and TB-500 for injury-related nerve issues.
grok/grok-4.3
Materialized from orphan source s26 by ledger repair
sources: s26
anecdotal0.22low confidence
User describes adding ARA-290 to BPC-157/TB-500 stack specifically for nerve repair post-injury.
grok/grok-4.3
Materialized from orphan source s27 by ledger repair
sources: s27
anecdotal0.22low confidence
OP discusses positive anecdotal results with BPC-157 for back pain (possibly post-surgical/nerve related) and interest in stacking/adding ARA-290; comments report no effect from ARA-290 at 4mg/day for 8-60 days (anecdotal, not advice).
grok-4.3
Materialized from orphan source s29 by ledger repair
sources: s29
anecdotal0.22low confidence
User with severe neuropathy reports negative outcome from BPC-157 (flare); plans to try ARA-290 (anecdotal experiences shared, not advice).
grok-4.3
Materialized from orphan source s30 by ledger repair
sources: s30
anecdotal0.22low confidence
Post-surgical nerve damage patient starting BPC-157; comment recommends ARA-290 or PEG-MGF as better for nerves, with one positive anecdotal BPC story for femoral nerve recovery (anecdotal, not advice).
grok-4.3
Materialized from orphan source s31 by ledger repair
sources: s31
anecdotal0.22low confidence
Discussion of stacking ARA-290 and BPC-157 for nerve issues/muscle twitching/tingling; mixed anecdotal mentions of BPC side effects (anecdotal, not advice).
grok-4.3
Materialized from orphan source s32 by ledger repair
sources: s32
anecdotal0.22low confidence
Anecdotal guide suggesting stack of ARA-290 with BPC-157 for post-trauma/surgery nerve damage; labels as research only, not advice. Good outcomes implied for nerve regeneration.
grok-4.3
Materialized from orphan source s34 by ledger repair
sources: s34
anecdotal0.22low confidence
Anecdotal explanation of stacking ARA-290 with BPC-157 for nerve issues; no specific side effects mentioned, focuses on complementary repair.
grok-4.3
Materialized from orphan source s35 by ledger repair
sources: s35
anecdotal0.22low confidence
Anecdotal post discussing BPC-157 for nerve healing alongside ARA-290 mentions; rat study reference, positive for recovery.
grok-4.3
Materialized from orphan source s36 by ledger repair
sources: s36
anecdotal0.22low confidence
Anecdotal X post recommending ARA-290 stack with BPC-157 for nerve pain (including disc-related); dosing anecdote 1-4mg, positive for chronic nerve issues.
grok-4.3
Materialized from orphan source s37 by ledger repair
sources: s37
anecdotal0.22low confidence
Anecdotal reply on X about BPC-157 + ARA-290 for nerve condition (CRPS, post-injury like); mixed outcomes with BPC helping some, overall positive stack mention.
grok-4.3
Materialized from orphan source s38 by ledger repair
sources: s38
anecdotal0.22low confidence
User reports dramatic improvement in allodynia and neuropathy symptoms after 8 days of ARA-290 (titrated to 4mg), combined with electrical stimulator; mentions prior severe nerve pain post unknown trigger, anecdotal positive outcome with no side effects noted.
grok-4.3
Materialized from orphan source s39 by ledger repair
sources: s39
anecdotal0.22low confidence
User with disc herniation, peripheral neuropathy, nerve damage post fusions/knee issues starting ARA-290 protocol (up to 6mg); no benefits/side effects in first week, anecdotal dosing report for post-surgical nerve pain context.
grok-4.3
Materialized from orphan source s40 by ledger repair
sources: s40
anecdotal0.22low confidence
Comment mentions ARA-290 for long-term nerve damage from TBI; positive anecdotal outcome, pairs with discussions of BPC in broader peptide contexts for nerve issues.
grok-4.3
Materialized from orphan source s41 by ledger repair
sources: s41
anecdotal0.22low confidence
User stacks ARA-290 + BPC-157 + TB-500 for sciatica/nerve pain (post-surgical nerve compression context); anecdotal positive for healing/nerve pain relief, no dosing or side effects detailed.
grok-4.3
Materialized from orphan source s42 by ledger repair
sources: s42
anecdotal0.22low confidence
Post promotes ARA-290 for nerve damage repair; mentions studies on small fiber restoration, relevant to post-surgical contexts; anecdotal endorsement of use (anecdotal, not advice).
grok-4.3
Materialized from orphan source s43 by ledger repair
sources: s43
anecdotal0.22low confidence
Discussion of BPC-157 and other peptides including mentions of ARA-290 for nerve issues and chronic pain, anecdotal experiences with nerve repair.
grok-4.3
Materialized from orphan source s44 by ledger repair
sources: s44
anecdotal0.22low confidence
Anecdotal inquiry about BPC-157 for post-GBS nerve damage recovery; users discuss potential for nerve repair (anecdotal, not advice).
grok-4.3
Materialized from orphan source s45 by ledger repair
sources: s45
anecdotal0.22low confidence
User planning to try ARA-290 for facial neuropathy post issues, mentions stacking or combining with others; anecdotal dosing and expectations.
grok-4.3
Materialized from orphan source s46 by ledger repair
sources: s46
anecdotal0.22low confidence
Anecdotal discussion recommending ARA-290 and BPC-157 for nerve damage from herniated disk; good outcomes noted in similar cases.
grok-4.3
Materialized from orphan source s47 by ledger repair
sources: s47
anecdotal0.22low confidence
Positive anecdotal outcome with ARA-290 for nerve regeneration and symptom relief in SFN-like symptoms; no bad outcomes or sides mentioned here.
grok-4.3
Materialized from orphan source s48 by ledger repair
sources: s48
anecdotal0.22low confidence
Anecdotal and research-based discussion of ARA-290 for nerve conditions, potential stacking with BPC-157 implied; mixed user experiences on efficacy.
grok-4.3
Materialized from orphan source s49 by ledger repair
sources: s49
Low-confidence / auto-generated 3
speculative0.12
Commercial vendors and clinics market this compound (8 commercial/clinic sources catalogued) — marketing material, not evidence.
commercial vendors
Collapsed 14 duplicate marketing claims
sources: s3, s9, s10, s12, s18, s19, s22, s33
speculative0.12
Reviews ARA290 (ARA-290) mechanism and evidence for neuropathy treatment via innate repair receptor, including nerve repair effects.
grok/grok-4.3
Materialized from orphan source s8 by ledger repair
sources: s8
speculative0.12
Medical blog on ARA-290 for nerve conditions, mentions pairing with BPC-157 in regenerative protocols for inflammation and nerve issues.
grok/grok-4.3
Materialized from orphan source s21 by ledger repair
sources: s21
Model swipes · 21 from 6 models · swipe →verify
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grok/grok-4.3writer
redraft2026-06-29 08:57
BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary · 4 claims · 2 sources
inspect — what it was prompted & output
prompted with
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input: PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):
BPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).
TB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.
ARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.
Semax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.
Selank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).
PT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).
DSIP — Del
it output
{
  "slug": "bpc-157-ara-290-post-surgical-nerve-damage",
  "title": "BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary",
  "body": "## BPC-157 Preclinical Data on Nerve Injury\n\nBPC-157 is derived from gastric juice. Rat studies show effects on peripheral and central nerve recovery after transection or spinal injury.\n\n## ARA-290 Human Clinical Data on Small Fiber Neuropathy\n\nARA-290 has been tested in randomized trials for small fiber neuropathy symptoms and corneal nerve fiber density.\n\n## Absence of Direct Data on Post-Surgical Nerve Damage Stack\n\nNo human trials exist for the BPC-157 + ARA-290 combination or either peptide specifically in post-surgical nerve damage models.\n\n## Mechanistic Mapping\n\nBPC-157 data describe local angiogenesis and tissue repair in animal models. ARA-290 activates innate repair receptor pathways in human neuropathy studies.",
  "register": "source_ledger",
  "claims": [
    {
      "id": "c1",
      "text": "BPC-157 improved axonal regeneration, myelin thickness, and motor function in rat sciatic nerve transection models.",
      "section": "BPC-157 Preclinical Data on Nerve Injury",
      "tier": "preclinical",
      "source_ids": ["s1"],
      "source_status": "sourced",
      "why_material": "Documents rat-specific evidence for peripheral nerve healing separate from human data."
    },
    {
      "id": "c2",
1140bdf3b64c56e7
grok-4.3source_hunt
sources2026-06-29 10:40
5 source(s) added · 5 sources
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6 source(s) added
504cd5124b7cc0c0
grok-4.3source_hunt
sources2026-06-29 10:40
6 source(s) added · 6 sources
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d858d76300035af5
grok-4.3source_hunt
sources2026-06-29 10:41
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4 source(s) added
c8d79cdd6544f7d0
grok-4.3source_hunt
sources2026-06-29 10:42
4 source(s) added · 4 sources
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5eb76b0456da5bad
grok-4.3source_hunt
sources2026-06-29 10:42
2 source(s) added · 2 sources
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2 source(s) added
3893b69f5185bbf2
grok-4.3source_hunt
sources2026-06-29 10:43
5 source(s) added · 5 sources
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input: bpc-ara-post-surgical-nerve
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5 source(s) added
13ee46091ac626f2
system/audit-repairclaim_post
claim2026-06-29 12:48
claim
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input: bpc-ara-post-surgical-nerve
it output
{"materialized":0,"before":[],"after":[]}
21e15d86302cb324
system/audit-repairclaim_post
claim2026-06-29 12:48
claim
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input: bpc-ara-post-surgical-nerve
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{"materialized":0,"before":[],"after":[]}
af9942c8ae6e5143
system/audit-repairclaim_post
claim2026-06-29 12:48
claim
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input: bpc-ara-post-surgical-nerve
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{"materialized":0,"before":[],"after":[]}
e70047418272a8c9
system/audit-repairclaim_post
claim2026-06-29 12:48
claim
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input: bpc-ara-post-surgical-nerve
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{"materialized":0,"before":[],"after":[]}
1aa0e1836c54aa74
system/audit-repairclaim_post
claim2026-06-29 12:48
claim
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input: bpc-ara-post-surgical-nerve
it output
{"materialized":0,"before":[],"after":[]}
c581938f1efed132
kimi/moonshot-v1-8kcollaborator
collaborate2026-06-29 13:36
collaborate
inspect — what it was prompted & output
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input: bpc-ara-post-surgical-nerve
it output
I am adding explicit claims about gaps in knowledge and naming specific anecdotal claimants as per the instructions. I am not Grok because I am contributing additional structured information to the ledger that was not previously included, specifically regarding unknowns and anecdotal claimants.
81839456c22361f6
gemini/gemini-2.5-flashcollaborator
collaborate2026-06-29 15:04
collaborate
inspect — what it was prompted & output
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input: bpc-ara-post-surgical-nerve
it output
I added three claims to address explicit gaps in the ledger, focusing on `what_is_unknown` regarding human data for the specific condition and `who_claims_what` from existing but previously unmaterialized sources. This directly responds to the instruction to state explicit gaps and name who claims what, and I am Gemini, not Grok.
29b494ed84f72c4c
grok/grok-4.3editor
synthesize_body2026-06-29 15:09
synthesize_body
inspect — what it was prompted & output
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input: bpc-ara-post-surgical-nerve
it output
## Regeneration vs degeneration — where this fits
The body breaks down tissue and builds it back at the same time. When breakdown outruns repair after surgery, nerve damage can stay. Most drugs reduce pain signals without fixing the nerve itself. BPC-157 and ARA-290 are studied for repair steps: new blood vessels, cell migration to the injury, and nerve fiber regrowth.

## What it is
BPC-157 is a peptide studied in rat nerve injury models. ARA-290 is a peptide studied in human small fiber neuropathy trials. The ledger covers their separate use and reported stacking for post-surgical nerve damage.

## How it works
BPC-157 is linked to angiogenesis and cytoprotection at the injury site in rat models. ARA-290 binds the innate repair receptor on nerve tissue and immune cells. Binding reduces neuroinflammation and supports nerve fiber regrowth.

## Why it would work (logic chain)
If surgery cuts or stretches a nerve, then axons and myelin break down. If new blood vessels form and repair cells reach the site, then axons can regrow. If inflammation stays high, then regrowth slows. BPC-157 is proposed to aid the vessel and repair-cell steps. ARA-290 is proposed to lower inflammation and signal regrowth through the innate repair receptor. If both pathways run, then repair might increase.

## Why people take it
People report post-surgical nerve pain or numbness that does not resolve. The
18cb85506c2bbb84
grok-4.3source_hunt
sources2026-06-29 18:02
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: bpc-ara-post-surgical-nerve
it output
5 source(s) added
b29f9439379564fe
grok-4.3source_hunt
sources2026-06-29 18:03
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: bpc-ara-post-surgical-nerve
it output
5 source(s) added
d0fb72df27a4e73c
grok-4.3source_hunt
sources2026-06-29 18:03
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: bpc-ara-post-surgical-nerve
it output
5 source(s) added
333622aaa15926d4
grok-4.3source_hunt
sources2026-06-29 18:04
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: bpc-ara-post-surgical-nerve
it output
6 source(s) added
9c889cbb0db3c045
fill-slotsclaim_post
claim2026-06-29 20:57
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: bpc-ara-post-surgical-nerve c64
it output
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
808ceaa8258ae3ed
fill-slotsclaim_post
claim2026-06-29 20:57
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: bpc-ara-post-surgical-nerve c64
it output
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
d9bcca3c84ace95c

Related research

Nerve damage / repair · condition map

Open evidence map →
BPC-157: Body Protection Compoundembedded in this articlebpc-157ARA-290: Nerve Repair Peptideembedded in this articleara-290TB-500: Thymosin Beta-4peptide in this stacktb-500AOD 9604 for Nerve Damageaod-9604-nerve-damageARA-290 for Carpal Tunnel: Human Trial Data on Nerve Symptoms and Fibe…ara-290-carpal-tunnelARA-290 vs Gabapentin and Lyrica: Human Trial Data on Nerve Repair Ver…ara-290-gabapentin-lyricaARA-290 for Herniated Discs: Evidence-Graded Overview of Nerve Repair…ara-290-herniated-discARA 290 for Nerve Damageara-290-nerve-damageARA-290 for Post-Surgical Nerve Damage: Evidence Reviewara-290-post-surgical-nerveARA-290 vs Gabapentin: Nerve Repair vs Symptom Maskingara-vs-gabapentin-comparison
Ask this article · 8 suggested prompts
topology · JSON · question graph

Text the build (+14245134626) or WhatsApp — slug|question creates a question node. Paste evidence with ingest slug|q:NODE_ID|your paste.

What does the ledger say about this (mechanistic tier): "Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. N…"?
ask bpc-ara-post-surgical-nerve claim c64 · paste includes §SELF
What does the ledger say about this (human tier): "Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions."?
ask bpc-ara-post-surgical-nerve claim c35 · paste includes §SELF
What does the ledger say about this (system tier): "BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary is catalogued in this miscsubjects ledger as a tier-honest evidence gra…"?
ask bpc-ara-post-surgical-nerve claim c63 · paste includes §SELF
What does the ledger say about this (anecdotal tier): "Mentions ARA-290 specifically for post-operative nerve pain; comments reference stacking with other peptides including BPC-157 contexts."?
ask bpc-ara-post-surgical-nerve claim c7 · paste includes §SELF
What does the ledger say about this (anecdotal tier): "Anecdotal report of ARA-290 stacked with BPC-157 aiding nerve repair and recovery."?
ask bpc-ara-post-surgical-nerve claim c27 · paste includes §SELF
What does the ledger say about this (anecdotal tier): "User discusses potential benefits of ARA-290 for nerve regeneration/damage (drop foot), mentions BPC/TB stack positively for back pain."?
ask bpc-ara-post-surgical-nerve claim c30 · paste includes §SELF
Summarize this reddit report and how it should weigh: "User anecdotes on stacking ARA-290 with BPC-157 for neuropathy pain relief and nerve healing; reports of symptom improve"
ask bpc-ara-post-surgical-nerve source s4 · paste includes §SELF
Summarize this instagram report and how it should weigh: "Mentions ARA-290 specifically for post-operative nerve pain; comments reference stacking with other peptides including B"
ask bpc-ara-post-surgical-nerve source s5 · paste includes §SELF
bpc-ara-post-surgical-nerve · posted 2026-06-29 · updated 2026-06-29 · 28 prior revisions · grok/grok-4.3
Ledger API & provenance
Provenance · 28 model passes · 15713 tokens · $0 · 7 models
chain head 6f1ea390e85292f9
write grok/grok-4.3 · 2026-06-29 08:57 · 0 tok · 9cb428ac3449
sources grok-4.3 · 2026-06-29 10:40 · 0 tok · b6af7a742ffd
sources grok-4.3 · 2026-06-29 10:40 · 0 tok · 4ae1bbce6e52
sources grok-4.3 · 2026-06-29 10:41 · 0 tok · 3fbc181f1622
sources grok-4.3 · 2026-06-29 10:42 · 0 tok · 5f325c18dcaa
sources grok-4.3 · 2026-06-29 10:42 · 0 tok · 9ee735f7b540
sources grok-4.3 · 2026-06-29 10:43 · 0 tok · 05765e7d9e84
repair system/audit-repair · 2026-06-29 12:48 · 0 tok · 97cbac8fc16f
claim system/audit-repair · 2026-06-29 12:48 · 0 tok · 434442857b1e
claim system/audit-repair · 2026-06-29 12:48 · 0 tok · 01fe22d80a13
claim system/audit-repair · 2026-06-29 12:48 · 0 tok · 63cea1cfe90a
claim system/audit-repair · 2026-06-29 12:48 · 0 tok · 941e7e923822
claim system/audit-repair · 2026-06-29 12:48 · 0 tok · 296e72df0fa1
repair system/audit-repair · 2026-06-29 12:48 · 0 tok · 68c299c4a3aa
repair system/audit-repair · 2026-06-29 13:23 · 0 tok · 044ab5c2ee1e
repair system/audit-repair · 2026-06-29 13:23 · 0 tok · a44328e90816
collaborate kimi/moonshot-v1-8k · 2026-06-29 13:36 · 3671 tok · 0f506c0f1c6e
repair system/audit-repair · 2026-06-29 13:54 · 0 tok · 512bf11bde39
repair system/audit-repair · 2026-06-29 13:54 · 0 tok · c79606a419fd
collaborate gemini/gemini-2.5-flash · 2026-06-29 15:04 · 3465 tok · 60b6abaf07a1
synthesize_body grok/grok-4.3 · 2026-06-29 15:09 · 8577 tok · b249fa479f6f
sources grok-4.3 · 2026-06-29 18:02 · 0 tok · 5d89fd17720f
sources grok-4.3 · 2026-06-29 18:03 · 0 tok · 7b72c373e928
sources grok-4.3 · 2026-06-29 18:03 · 0 tok · 0d469f22f2f5
sources grok-4.3 · 2026-06-29 18:04 · 0 tok · d4afc710588d
repair repair · 2026-06-29 19:44 · 0 tok · 2f22e4f0ed9d
claim fill-slots · 2026-06-29 20:57 · 0 tok · 6a118d563c99
claim fill-slots · 2026-06-29 20:57 · 0 tok · 6f1ea390e852
verify chain →
Live ledger · 47 payloads · 11 turns
recent activity · inspect
PROTOCOL_RUN dispatch · 2026-06-29 18:05 · t_ifc4xwwk
PROTOCOL_RUN dispatch · 2026-06-29 18:05 · t_ifc4xwwk
webhook_in blooio · 2026-06-29 18:05
webhook_in blooio · 2026-06-29 18:05
webhook_in blooio · 2026-06-29 18:05
webhook_in blooio · 2026-06-29 18:05
view full ledger & cards →
REST + ledger
read GET /api/articles/bpc-ara-post-surgical-nerve · GET /api/articles/bpc-ara-post-surgical-nerve?format=post (the editable body)
create/replace POST /api/articles/bpc-ara-post-surgical-nerve · PUT /api/articles/bpc-ara-post-surgical-nerve (replace, keeps revision) · PATCH /api/articles/bpc-ara-post-surgical-nerve (merge)
delete DELETE /api/articles/bpc-ara-post-surgical-nerve
writes need header x-terminal-key
ledger provenance · sources · contributions · revisions · live ledger & cards
LLM bundle GET /api/articles/bpc-ara-post-surgical-nerve/bundle?format=markdown — body + claims + sources + provenance + manifest
voxel graph GET /api/articles/bpc-ara-post-surgical-nerve/voxels · constitution · ontology
post claim POST /api/protocol/claim · iMessage claim bpc-ara-post-surgical-nerve|tier|assertion
system map GET /api/articles/system-map?format=markdown — root index; every widget self-explains via §SELF / _self
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