Evidence review

TB-500: Thymosin Beta-4

#peptide#tb-500
bundle · json · system map · manifest

Every copy includes §SELF — what this is, proof chain, and links to every other feature. No context required.

§SELF — this page explains the system
## §SELF — miscsubjects (paste without context)

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `human_page` — **Human article page**
Rendered article with claims, sources, copy widgets, ask prompts.
- **article slug:** `tb-500`
- **contains:** rendered article, copy widgets, claims, sources, ask prompts
- **how to use:** Use Copy for LLM or Copy system map — both paste without context.
- **read:** https://miscsubjects.com/a/tb-500

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/tb-500/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **bundle** — Paste-ready package: body + claims + sources + voxels + provenance + manifest + constitution. · https://miscsubjects.com/api/articles/tb-500/bundle?format=markdown
- **ask** — Answer only from topology; creates question_node with gaps and ingest_hint. · https://miscsubjects.com/api/articles/tb-500/prompts
- **topology** — Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER. · https://miscsubjects.com/api/articles/tb-500/topology

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

*Not medical advice. Tier-honest. Cite claim/source ids.*

Regeneration vs degeneration — where this fits

The body is always doing two things at once: breaking down (degeneration) and building back (regeneration). A condition persists when breakdown outruns repair. Most drugs used for symptoms suppress a signal (pain, acid, anxiety, inflammation) without fixing the tissue that caused the signal. Peptides in this ledger are studied for repair pathways: new blood vessels, repair-cell migration, nerve regrowth, gut lining, neural connections. This article maps one compound through that frame — what it is, how it is proposed to work, what evidence exists, and what people report.

This topic: TB-500 (thymosin beta-4) is studied for repair-cell migration and actin regulation — cells that need to reach an injury and rebuild structure. That is regeneration: move repair machinery to the damage.

What it is

2025 study on Tβ4's role in vascular injury repair via interaction with CCN5. Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration.

How it works

Step logic:

  1. 2025 study on Tβ4's role in vascular injury repair via interaction with CCN5.
  2. Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration.
  3. The claim that Tβ4 production declines approximately 60% by age 60 is not supported by the provided sources and lacks specific data to back up the assertion.
  4. New 2025 PubMed study on engineered tandem TB4 peptide for corneal healing, building on TB-500/TB4 research.
  5. Analysis of commercial TB500 products showing inconsistencies and adulteration.
  6. 2025 PubMed article on TB4 effects in cardiac remodeling and repair.
  7. The quality and consistency of commercially available TB-500 products are a concern, with some analyses indicating inconsistencies and adulteration.
  8. 2024 study showing Tβ4 promotes axon regeneration, relevant to tissue repair mechanisms.

Why it would work (logic chain)

  1. IF 2025 study on Tβ4's role in vascular injury repair via interaction with CCN5. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  2. IF Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  3. IF The claim that Tβ4 production declines approximately 60% by age 60 is not supported by the provided sources and lacks specific data to back up the assertion. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  4. IF New 2025 PubMed study on engineered tandem TB4 peptide for corneal healing, building on TB-500/TB4 research. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  5. IF Analysis of commercial TB500 products showing inconsistencies and adulteration. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  6. IF 2025 PubMed article on TB4 effects in cardiac remodeling and repair. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).

Why people take it

Reasons that appear in this ledger:

  1. User reports elbow injury (muscle/tendon from bench) healed after 3 weeks of TB-500 + BPC stack; good outcome.
  2. User reports long-standing shoulder injury healed with TB-500 + BPC; positive user experience for muscle repair.
  3. Mixed outcome: helps minor strains and inflammation but possible side effect of lipoma growth; not life-changing.
  4. Discussion of TB-500/Thymosin Beta-4 for healing, part of Wolverine Stack anecdotes implied in biohacking context. Not advice.
  5. Anecdotal positive outcome: TB-500 + BPC-157 for systemic tissue repair and reduced inflammation; no dosing details.
  6. X post with anecdotal dosing (500mcg each 3x/week) for chronic pain/old injuries using TB-500 + BPC-157 combo (anecdotal, not advice).
  7. Anecdotal report of side effects including joint and muscle pain from (contextual) peptide use involving TB-500. Bad outcome/side effect anecdote. (anecdotal, not advice).
  8. Anecdotal mention of TB-500 for faster soft tissue and muscle recovery (anecdotal, not advice).
  9. Anecdotal user report on using TB-500 (with BPC-157) for meniscus injury recovery.
  10. User anecdote on using BPC-157 + TB-500 post-ACLR surgery for recovery support.

How many people take it

There is no reliable global count of how many people take this compound. That number is not in this ledger.

What we can count from this ledger:

  • 73 anecdote source(s) (posts, threads, comments)
  • 74 anecdote-tier claim(s) derived from them

Logic: 73 online report(s) are catalogued here. That proves some people are talking about using it — not how many exist in total. Multiple posts may be the same person or the same community; this is a sample, not a census.

Evidence inventory

This is a count of what is in this ledger — not a claim about all research worldwide.

  • Scientific sources catalogued (PubMed, trials, reviews): 25
  • Claims tagged human evidence: 14
  • Claims tagged preclinical (animal/lab): 4
  • Claims tagged anecdotal: 74
  • Reddit posts catalogued: 48
  • X posts catalogued: 21
  • Other anecdote sources (YouTube, Instagram, etc.): 4
  • Total sources in chain: 98

Quantified confidence (this ledger): 0.95 / 1.00 — moderate — human claims present in ledger

Formula: human claims×0.12 + preclinical×0.04 + anecdote×0.015 + studies (capped). This is not clinical certainty — it measures how much graded evidence is catalogued here.

What scientists say

Thymosin β4: a multi-functional regenerative peptide (source s1)

Review of Tβ4 biology and potential clinical uses in repair.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Thymosin beta4 accelerates wound healing (source s2)

Rat wound healing study.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers (source s3)

Phase 1 human safety data.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

The Regenerative Peptide Thymosin β4 Accelerates the Rate of Dermal Healing (source s4)

Human Phase 2 wound healing results.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Therapeutic Peptides in Orthopaedics: Applications, ... (source s5)

2026 review discussing TB-500 in orthopaedic wound healing and tissue repair.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Injectable Peptide Therapy: A Primer for Orthopaedic and ... (source s6)

2026 review on peptides including TB-500, noting preclinical promise but lack of human orthopaedic data.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Simultaneous quantification of TB-500 and its metabolites ... (source s7)

2024 study on analytical methods for TB-500 and metabolites, with wound healing screening.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

TB500/TB1000 and SGF1000: A scientific approach for a ... (source s8)

Analysis of commercial TB500 products showing inconsistencies and adulteration.

Evidence type: Published research.

Recombinant human thymosin beta 4 improves ischemic ... (source s9)

2025/2026 study on rhTB4 (related to TB-500) for ischemic injury in models.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

Thymosin beta 4 as an Alzheimer disease intervention (source s12)

Discusses thymosin beta 4 (Tβ4) expression decrease in Alzheimer's models and patients, suggesting potential intervention role.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Alkaline Phosphatase-Triggered Spatiotemporal Repair of Corneal Injury with TB500 Peptide Hydrogel (source s13)

First ocular application of TB500 in enzyme-responsive hydrogel for corneal injury repair in preclinical study.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Thymosin beta 4: An emerging therapeutic candidate for kidney diseases (source s14)

Review on Tβ4 as therapeutic candidate for kidney diseases, focusing on fibrosis, inflammation.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Safety and Efficacy Study of Thymosin Beta 4 in Patients With Acute Myocardial Infarction (source s15)

Ongoing or listed Phase IIa trial of recombinant human thymosin beta 4 for AMI patients.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Engineered Tandem Thymosin Peptide Promotes Corneal Wound Healing (source s22)

New 2025 PubMed study on engineered tandem TB4 peptide for corneal healing, building on TB-500/TB4 research.

Evidence type: Published research.

Thymosin Beta-4 Modulates Cardiac Remodeling by Promoting Myocardial Cell Survival (source s23)

2025 PubMed article on TB4 effects in cardiac remodeling and repair.

Evidence type: Published research.

A Phase 1a Study of Thymosin Beta 4 in Healthy Volunteers (source s24)

New clinical trial entry for Thymosin Beta 4 safety in healthy volunteers, distinct from listed NCT05485818.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

A Study of the Safety and Efficacy of Injectable Thymosin Beta 4 (source s25)

Additional Thymosin Beta 4 clinical trial not in collected list.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Thymosin Beta-4 and TB-500 in Tissue Healing and Musculoskeletal Medicine (source s26)

2026 review article specifically on TB4 and TB-500 for healing.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

What people say on Reddit

BPC-157, TB-500, and The Wolverine Stack Explained — Reddit, r/ScienceBioTechnology (source s10)

Reddit discussion on TB-500 mechanism for tissue regeneration based on preclinical data.

Any experience with muscle/tissue repair? Tb-500? — Reddit, r/AskMenOver30 (source s11)

Anecdotal user report on using TB-500 (with BPC-157) for meniscus injury recovery.

Documenting My ACLR + Meniscus Repair Journey – Trying the “Wolverine Stack” (BPC-157 + TB-500) — Reddit, r/ACL (source s16)

User anecdote on using BPC-157 + TB-500 post-ACLR surgery for recovery support.

I was hospitalised after running TB-500 — Reddit, r/PeptidePathways (source s18)

User reports severe allergic reaction (hives, throat swelling) leading to hospitalization after using TB-500 (continued after stopping BPC), bad outcome.

Strange side effects of BPC 157 and TB 500 — Reddit, r/bpc_157 (source s19)

Post discussing strange side effects from BPC-157 + TB-500 combination, user-reported experiences (mixed/good/bad implied in thread).

Thymosin Beta 4: Genetics & Supplemental Peptides — Reddit, r/geneticlifehacks (source s27)

Recent Reddit anecdote/discussion on TB-500 and TB4 supplementation and genetics.

BPC 157 & TB500 -experience ? — Reddit, r/ACL (source s28)

User anecdote on TB-500 + BPC-157 for ACL recovery.

Healing Compounds - BPC-157, TB-500 — Reddit, r/steroids (source s36)

User reports total success with TB-500 combo for healing after 8 weeks.

BPC-157 and TB-500 Therapy Log — Reddit, r/PlantarFasciitis (source s37)

Positive drastic healing reported for plantar fasciitis with TB-500/BPC combo.

My experience with TB500/BPC157 — Reddit, r/Biohackers (source s38)

User describes near-complete knee pain resolution and 95% improvement with TB-500/BPC-157.

Meniscus Tear and BPC 157 TB500 — Reddit, r/MeniscusInjuries (source s39)

User reports rapid pain relief, muscle rebuilding, and 80% healing of meniscus injury with TB-500/BPC.

BPC-157 and TB-500 no results after 6 weeks — Reddit, r/bpc_157 (source s40)

User reports no noticeable relief or results after weeks of TB-500/BPC-157 use.

Thoughts on BPC-157? — Reddit, r/crossfit (source s41)

User reports significant pain reduction in what seems to be a muscle/tendon issue after adding TB-500 to regimen; attributes possible healing benefit.

Thoughts on BPC-157? — Reddit, r/crossfit (source s42)

User confirms best healing results from combining with TB-500 for injury recovery.

Experience with BPC-157 and Elbow Tendinopathy — Reddit, r/climbharder (source s43)

User reports TB-500 (with BPC) cured elbow tendonitis in 4-6 weeks; positive outcome for soft tissue repair.

BPC157/TB500 to heal TFCC tear? — Reddit, r/bpc_157 (source s44)

User reports combo sped up healing of persistent pain/TFCC issues alongside meniscus treatment.

What people say on X

X post by TylerD — X (source s45)

User reports elbow injury (muscle/tendon from bench) healed after 3 weeks of TB-500 + BPC stack; good outcome.

X post by The Dad Experiment — X (source s46)

User reports long-standing shoulder injury healed with TB-500 + BPC; positive user experience for muscle repair.

X post on TB-500 experiences — X (source s51)

Mixed outcome: helps minor strains and inflammation but possible side effect of lipoma growth; not life-changing.

X post on BPC-157 and TB-500 — X (source s59)

Discussion of TB-500/Thymosin Beta-4 for healing, part of Wolverine Stack anecdotes implied in biohacking context. Not advice.

X post distinguishing TB-500 and Thymosin Beta-4 — X (source s60)

Clarification on TB-500 as fragment of Thymosin Beta-4, relevant to muscle repair research. Not advice.

Post about TB-500 — X (source s65)

Anecdotal positive outcome: TB-500 + BPC-157 for systemic tissue repair and reduced inflammation; no dosing details.

Post about TB-500 and BPC-157 — X (source s66)

Anecdotal recommendation for stacking TB-500 (thymosin beta-4 fragment) with BPC for muscle/tissue repair via complementary pathways.

KLOW blend post on TB-500 role in repair — X (source s70)

X post explaining TB-500 (thymosin beta-4) for cell migration and tissue repair; dosing and stacking anecdotes (anecdotal, not advice).

Pairing BPC with TB500 for pain/injuries — X (source s73)

X post with anecdotal dosing (500mcg each 3x/week) for chronic pain/old injuries using TB-500 + BPC-157 combo (anecdotal, not advice).

BowTiedYukon post on TB-500 — X (source s78)

Anecdotal discussion of TB-500 (thymosin beta-4) for muscle repair and tissue healing (anecdotal, not advice).

morellifit on BPC-157 + TB-500 — X (source s79)

Positive anecdotal outcome for muscle regeneration and inflammation reduction with TB-500 stack (anecdotal, not advice).

APeptides on Wolverine Stack — X (source s80)

Anecdotal mention of TB-500 for tissue repair in recovery protocols (anecdotal, not advice).

lawyerschiff on TB-500 — X (source s81)

Anecdotal benefits for cell migration and inflammation in repair (anecdotal, not advice).

BowTiedYukon on TB500 stock — X (source s82)

Discussion of TB-500 promoting tissue and muscle repair (anecdotal, not advice).

Giotraining on Wolverine Stack — X (source s83)

Anecdotal use in recovery protocols for tissue repair (anecdotal, not advice).

How TB-500 Works post — X (source s88)

Detailed explanation of TB-500 mechanisms for muscle/tendon repair, cell migration, angiogenesis, and reducing scar tissue/fibrosis. (informational).

L
LiveWellWithDrG ✓
@LiveWellWithDrG · 2026-06-29
🧬 How TB-500 Works: The Cellular Blueprint of Tissue Repair ... TB-500 (a synthetic fragment of the naturally occurring peptide Thymosin Beta-4) intervenes directly at the genomic and cellular level to force structural remodeling. ... This ensures that new muscle and tendon fibers align perfectly in parallel, restoring pristine tissue flexibility and explosive structural strength rather than a stiff, knotted patch.
View on X →
2026-06-29 17:05s88 · #0c74d64f8fdc

Other anecdote evidence

What Science ACTUALLY Says About TB 500 Benefits — YouTube (source s17)

Video reviewing scientific evidence on TB-500 for injury recovery, referencing PubMed studies.

I Took The Wolverine Stack & My Thoughts On BPC-157 & TB-500 — YouTube (source s20)

Chiropractor shares personal positive experience with BPC-157 + TB-500 for stubborn injury: faster healing, less inflammation and flare-ups (with rehab), some injection site tenderness noted.

TB-500 for Injury Recovery – Does it Work and is it Safe? — YouTube (source s21)

YouTube comments include user reports of rapid pain relief from TB-500 + BPC-157 injections (good outcome); others mention rotator cuff improvement in ~1-2 weeks.

TB-500 (Thymosin Beta 4) Benefits & Risks — YouTube (source s52)

Anecdotal report of rapid healing of rotator cuff and other injuries with TB-500 + BPC-157 stack.

What we do not know

  1. The quality and consistency of commercially available TB-500 products are a concern, with some analyses indicating inconsistencies and adulteration.
  2. The results of the ongoing or listed Phase IIa trial investigating recombinant human thymosin beta 4 for acute myocardial infarction (AMI) patients are not yet publicly available.

Safety and limits

  1. 2025 study on Tβ4's role in vascular injury repair via interaction with CCN5.

---

Not medical advice. Counts and quotes are from this article's hash-chained ledger. Anecdote = real reports, not proof. Animal studies ≠ human proof.

TB 500 · peptide map

Evidence map

Hover a node — its path lights up. Click to open the article.

Full map →
JumpAging Repair Stack: BPC-157 + TB-500 + GHK-Cu · 12 humanRecovery Stack for Complex Injuries: BPC-157 + TB-500 + ARA-290 · 7 humanTB 500 for Benzo WithdrawalTB 500 for Benzodiazepines
Evidence · 98 sources · swipe →chain 8ab1cae9aac1 · verify chain · provenance
1 / 98
L
LiveWellWithDrG ✓
@LiveWellWithDrG · 2026-06-29
🧬 How TB-500 Works: The Cellular Blueprint of Tissue Repair ... TB-500 (a synthetic fragment of the naturally occurring peptide Thymosin Beta-4) intervenes directly at the genomic and cellular level to force structural remodeling. ... This ensures that new muscle and tendon fibers align perfectly in parallel, restoring pristine tissue flexibility and explosive structural strength rather than a stiff, knotted patch.
View on X →
2026-06-29 17:05s88 · #0c74d64f8fdc
Evidence ledger 100 · tier-ranked · API
mechanistic
2025 study on Tβ4's role in vascular injury repair via interaction with CCN5.
sources: s33
human
Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration.
sources: s1
human
Intravenous synthetic Tβ4 was well tolerated in Phase 1 single- and multiple-dose studies in healthy volunteers with no dose-limiting toxicity.
sources: s3
human
Topical Tβ4 accelerated healing by nearly one month in Phase 2 trials of stasis and pressure ulcers in some patients who healed.
sources: s4
human
Commercial vendors and clinics market this compound (7 commercial/clinic sources catalogued) — marketing material, not evidence.
sources: s6, s10, s13, s24, s25, s1, s32
94 more ranked claims
human0.80
Review on Tβ4 as therapeutic candidate for kidney diseases, focusing on fibrosis, inflammation.
grok/grok-4.3
Materialized from orphan source s14 by ledger repair
sources: s14
human0.80
Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
system/protocol
Required constitution slot: disclaimer
preclinical0.50
Topical or systemic Tβ4 accelerates wound healing and re-epithelialization in rat full-thickness wound models.
system/repair
Distinguishes rat data from human.
sources: s2
preclinical0.50
2024 study on analytical methods for TB-500 and metabolites, with wound healing screening.
grok/grok-4.3
Materialized from orphan source s7 by ledger repair
sources: s7
preclinical0.40
While Tβ4 expression has been observed to decrease in Alzheimer's models and patients, the specific claim of a 60% decline by age 60 is unsourced and lacks specific supporting evidence in the provided topology.
gemini/gemini-2.5-flash (adversary)
Challenges an unsourced, quantified claim about age-related decline by contrasting it with a sourced, more nuanced observation of Tβ4 decrease in a disease context, highlighting the lack of evidence for the specific percentage.
mechanistic0.40
The claim that Tβ4 production declines approximately 60% by age 60 is not supported by the provided sources and lacks specific data to back up the assertion.
kimi/moonshot-v1-8k (adversary)
The claim is unsourced and makes a specific quantitative assertion without evidence from the listed sources, which is why it is challenged.
mechanistic0.30
New 2025 PubMed study on engineered tandem TB4 peptide for corneal healing, building on TB-500/TB4 research.
grok/grok-4.3
Materialized from orphan source s22 by ledger repair
sources: s22
anecdotal0.30
User reports elbow injury (muscle/tendon from bench) healed after 3 weeks of TB-500 + BPC stack; good outcome.
grok-4.3
Materialized from orphan source s45 by ledger repair
sources: s45
anecdotal0.30
User reports long-standing shoulder injury healed with TB-500 + BPC; positive user experience for muscle repair.
grok-4.3
Materialized from orphan source s46 by ledger repair
sources: s46
anecdotal0.30
Mixed outcome: helps minor strains and inflammation but possible side effect of lipoma growth; not life-changing.
grok-4.3
Materialized from orphan source s51 by ledger repair
sources: s51
anecdotal0.30
Discussion of TB-500/Thymosin Beta-4 for healing, part of Wolverine Stack anecdotes implied in biohacking context. Not advice.
grok-4.3
Materialized from orphan source s59 by ledger repair
sources: s59
anecdotal0.30
Anecdotal positive outcome: TB-500 + BPC-157 for systemic tissue repair and reduced inflammation; no dosing details.
grok-4.3
Materialized from orphan source s65 by ledger repair
sources: s65
anecdotal0.30
X post with anecdotal dosing (500mcg each 3x/week) for chronic pain/old injuries using TB-500 + BPC-157 combo (anecdotal, not advice).
grok-4.3
Materialized from orphan source s73 by ledger repair
sources: s73
anecdotal0.30
Anecdotal report of side effects including joint and muscle pain from (contextual) peptide use involving TB-500. Bad outcome/side effect anecdote. (anecdotal, not advice)
grok-4.3
Materialized from orphan source s89 by ledger repair
sources: s89
anecdotal0.30
Anecdotal mention of TB-500 for faster soft tissue and muscle recovery (anecdotal, not advice)
grok-4.3
Materialized from orphan source s91 by ledger repair
sources: s91
human0.22low confidence
2026 review discussing TB-500 in orthopaedic wound healing and tissue repair.
grok/grok-4.3
Materialized from orphan source s5 by ledger repair
sources: s5
human0.22low confidence
Discusses thymosin beta 4 (Tβ4) expression decrease in Alzheimer's models and patients, suggesting potential intervention role.
grok/grok-4.3
Materialized from orphan source s12 by ledger repair
sources: s12
human0.22
Ongoing or listed Phase IIa trial of recombinant human thymosin beta 4 for AMI patients.
grok/grok-4.3
Materialized from orphan source s15 by ledger repair
sources: s15
human0.22low confidence
2026 review article specifically on TB4 and TB-500 for healing.
grok/grok-4.3
Materialized from orphan source s26 by ledger repair
sources: s26
human0.22
New 2026 Phase IIc trial of recombinant human thymosin beta-4 for heart damage post-MI.
grok/grok-4.3
Materialized from orphan source s29 by ledger repair
sources: s29
human0.22low confidence
2026 review on therapeutic peptides including TB-500 for orthopaedic applications like muscle/tendon repair.
grok/grok-4.3
Materialized from orphan source s30 by ledger repair
sources: s30
human0.22low confidence
2024 narrative review covering peptide therapies including thymosin beta-4/TB-500 for soft tissue and muscle repair.
grok/grok-4.3
Materialized from orphan source s31 by ledger repair
sources: s31
human0.22low confidence
2025 review mentioning TB4/TB-500 in context of combined peptide use for musculoskeletal healing and pain.
grok-4.3
Materialized from orphan source s35 by ledger repair
sources: s35
preclinical0.22low confidence
2025/2026 study on rhTB4 (related to TB-500) for ischemic injury in models.
grok/grok-4.3
Materialized from orphan source s9 by ledger repair
sources: s9
mechanistic0.22low confidence
Analysis of commercial TB500 products showing inconsistencies and adulteration.
grok/grok-4.3
Materialized from orphan source s8 by ledger repair
sources: s8
mechanistic0.22low confidence
2025 PubMed article on TB4 effects in cardiac remodeling and repair.
grok/grok-4.3
Materialized from orphan source s23 by ledger repair
sources: s23
mechanistic0.22low confidence
The quality and consistency of commercially available TB-500 products are a concern, with some analyses indicating inconsistencies and adulteration.
gemini/gemini-2.5-flash
Highlights a significant unknown regarding product reliability and potential safety for users, based on analytical findings.
sources: s8
mechanistic0.22low confidence
2024 study showing Tβ4 promotes axon regeneration, relevant to tissue repair mechanisms.
grok-4.3
Materialized from orphan source s34 by ledger repair
sources: s34
anecdotal0.22low confidence
Anecdotal user report on using TB-500 (with BPC-157) for meniscus injury recovery.
grok/grok-4.3
Materialized from orphan source s11 by ledger repair
sources: s11
anecdotal0.22low confidence
User anecdote on using BPC-157 + TB-500 post-ACLR surgery for recovery support.
grok/grok-4.3
Materialized from orphan source s16 by ledger repair
sources: s16
anecdotal0.22low confidence
Video reviewing scientific evidence on TB-500 for injury recovery, referencing PubMed studies.
grok/grok-4.3
Materialized from orphan source s17 by ledger repair
sources: s17
anecdotal0.22low confidence
User reports severe allergic reaction (hives, throat swelling) leading to hospitalization after using TB-500 (continued after stopping BPC), bad outcome.
grok/grok-4.3
Materialized from orphan source s18 by ledger repair
sources: s18
anecdotal0.22low confidence
Post discussing strange side effects from BPC-157 + TB-500 combination, user-reported experiences (mixed/good/bad implied in thread).
grok/grok-4.3
Materialized from orphan source s19 by ledger repair
sources: s19
anecdotal0.22low confidence
Chiropractor shares personal positive experience with BPC-157 + TB-500 for stubborn injury: faster healing, less inflammation and flare-ups (with rehab), some injection site tenderness noted.
grok/grok-4.3
Materialized from orphan source s20 by ledger repair
sources: s20
anecdotal0.22low confidence
YouTube comments include user reports of rapid pain relief from TB-500 + BPC-157 injections (good outcome); others mention rotator cuff improvement in ~1-2 weeks.
grok/grok-4.3
Materialized from orphan source s21 by ledger repair
sources: s21
anecdotal0.22low confidence
Recent Reddit anecdote/discussion on TB-500 and TB4 supplementation and genetics.
grok/grok-4.3
Materialized from orphan source s27 by ledger repair
sources: s27
anecdotal0.22low confidence
User anecdote on TB-500 + BPC-157 for ACL recovery.
grok/grok-4.3
Materialized from orphan source s28 by ledger repair
sources: s28
anecdotal0.22low confidence
Anecdotal reports from users on platforms like Reddit claim TB-500 aids in tissue regeneration, but these claims lack rigorous scientific validation and should be approached with caution.
kimi/moonshot-v1-8k
This claim explicitly names the source of anecdotal evidence, which was missing in the original claims, thus adhering to the instruction to name who claims what from anecdotes.
sources: s10
anecdotal0.22low confidence
The results of the ongoing or listed Phase IIa trial investigating recombinant human thymosin beta 4 for acute myocardial infarction (AMI) patients are not yet publicly available.
gemini/gemini-2.5-flash
Points to a critical unknown in the human clinical development of Tβ4 for a specific indication, indicating ongoing research without published outcomes.
sources: s16
anecdotal0.22low confidence
User reports total success with TB-500 combo for healing after 8 weeks.
grok-4.3
Materialized from orphan source s36 by ledger repair
sources: s36
anecdotal0.22low confidence
Positive drastic healing reported for plantar fasciitis with TB-500/BPC combo.
grok-4.3
Materialized from orphan source s37 by ledger repair
sources: s37
anecdotal0.22low confidence
User describes near-complete knee pain resolution and 95% improvement with TB-500/BPC-157.
grok-4.3
Materialized from orphan source s38 by ledger repair
sources: s38
anecdotal0.22low confidence
User reports rapid pain relief, muscle rebuilding, and 80% healing of meniscus injury with TB-500/BPC.
grok-4.3
Materialized from orphan source s39 by ledger repair
sources: s39
anecdotal0.22low confidence
User reports no noticeable relief or results after weeks of TB-500/BPC-157 use.
grok-4.3
Materialized from orphan source s40 by ledger repair
sources: s40
anecdotal0.22low confidence
User reports significant pain reduction in what seems to be a muscle/tendon issue after adding TB-500 to regimen; attributes possible healing benefit.
grok-4.3
Materialized from orphan source s41 by ledger repair
sources: s41
anecdotal0.22low confidence
User confirms best healing results from combining with TB-500 for injury recovery.
grok-4.3
Materialized from orphan source s42 by ledger repair
sources: s42
anecdotal0.22low confidence
User reports TB-500 (with BPC) cured elbow tendonitis in 4-6 weeks; positive outcome for soft tissue repair.
grok-4.3
Materialized from orphan source s43 by ledger repair
sources: s43
anecdotal0.22low confidence
User reports combo sped up healing of persistent pain/TFCC issues alongside meniscus treatment.
grok-4.3
Materialized from orphan source s44 by ledger repair
sources: s44
anecdotal0.22low confidence
User reports personal benefit from high-dose TB-500 injection for armwrestling-related tissue repair.
grok-4.3
Materialized from orphan source s47 by ledger repair
sources: s47
anecdotal0.22low confidence
Discussion on TB-500's role in speeding muscle fiber and tendon repair.
grok-4.3
Materialized from orphan source s48 by ledger repair
sources: s48
anecdotal0.22low confidence
Seeking and sharing experiences with TB-500 stack for chronic tendon issues.
grok-4.3
Materialized from orphan source s49 by ledger repair
sources: s49
anecdotal0.22low confidence
Post on systemic repair effects for chronic injuries.
grok-4.3
Materialized from orphan source s50 by ledger repair
sources: s50
anecdotal0.22low confidence
Anecdotal report of rapid healing of rotator cuff and other injuries with TB-500 + BPC-157 stack.
grok-4.3
Materialized from orphan source s52 by ledger repair
sources: s52
anecdotal0.22low confidence
User reports rapid improvement in ketamine-induced cystitis symptoms (frequency, pain, stream) after starting BPC-157 + TB-500 stack, feeling much better in 2 weeks.
grok-4.3
Materialized from orphan source s53 by ledger repair
sources: s53
anecdotal0.22low confidence
User experienced severe acute side effects (migraine, dizziness, nausea, overstimulation) shortly after starting BPC-157 + TB-500, feeling set back from TBI baseline; later updated to mostly recovered after a week or two.
grok-4.3
Materialized from orphan source s54 by ledger repair
sources: s54
anecdotal0.22low confidence
Anecdotal positive experience with TB-500 (TB4) dosing for muscle spasticity and pain reduction in EDS/HSD context; no side effects mentioned. Not advice.
grok-4.3
Materialized from orphan source s55 by ledger repair
sources: s55
anecdotal0.22low confidence
Anecdotal use of TB-500 with BPC-157 for spinal injury recovery alongside PRP; positive implied. Dosing not specified. Not advice.
grok-4.3
Materialized from orphan source s56 by ledger repair
sources: s56
anecdotal0.22low confidence
Anecdotal experience with split local injections of TB-500/BPC for shoulder and hip injuries; systemic effects noted. Not advice.
grok-4.3
Materialized from orphan source s57 by ledger repair
sources: s57
anecdotal0.22low confidence
Anecdotal strong positive outcome for Achilles tendonitis with TB-500 + BPC-157 over 6 weeks. Not advice.
grok-4.3
Materialized from orphan source s58 by ledger repair
sources: s58
anecdotal0.22low confidence
Clarification on TB-500 as fragment of Thymosin Beta-4, relevant to muscle repair research. Not advice.
grok-4.3
Materialized from orphan source s60 by ledger repair
sources: s60
anecdotal0.22low confidence
Anecdotal discussion of TB-500 for post-surgery muscle/tissue repair; mentions benefits for muscle recovery but no specific personal dosing or outcomes detailed in snippet.
grok-4.3
Materialized from orphan source s61 by ledger repair
sources: s61
anecdotal0.22low confidence
Explains difference; anecdotal notes on TB-500 (fragment) for muscle injury repair vs full TB4.
grok-4.3
Materialized from orphan source s62 by ledger repair
sources: s62
anecdotal0.22low confidence
Anecdotal dosing guide (e.g., 2mg blend 2x/week loading) and notes mild side effects like fatigue; labels as research only, not advice.
grok-4.3
Materialized from orphan source s63 by ledger repair
sources: s63
anecdotal0.22low confidence
User seeking/ sharing anecdotal experiences with TB-500 + BPC for ACL/muscle repair post-surgery.
grok-4.3
Materialized from orphan source s64 by ledger repair
sources: s64
anecdotal0.22low confidence
Anecdotal recommendation for stacking TB-500 (thymosin beta-4 fragment) with BPC for muscle/tissue repair via complementary pathways.
grok-4.3
Materialized from orphan source s66 by ledger repair
sources: s66
anecdotal0.22low confidence
User review of 50-day BPC/TB-500 combo for recovery; dosing and half-life anecdotes (anecdotal, not advice).
grok-4.3
Materialized from orphan source s67 by ledger repair
sources: s67
anecdotal0.22low confidence
Thread seeking experiences with TB-500/BPC for knee recovery post-MACI; muscle/tissue repair context (anecdotal).
grok-4.3
Materialized from orphan source s68 by ledger repair
sources: s68
anecdotal0.22low confidence
Query on TB-500 for inflammation-related issues; potential side effects or outcomes discussed in comments (anecdotal).
grok-4.3
Materialized from orphan source s69 by ledger repair
sources: s69
anecdotal0.22low confidence
X post explaining TB-500 (thymosin beta-4) for cell migration and tissue repair; dosing and stacking anecdotes (anecdotal, not advice).
grok-4.3
Materialized from orphan source s70 by ledger repair
sources: s70
anecdotal0.22low confidence
Anecdotal report of using BPC-157/TB-500 blend (0.2ml twice daily subQ in belly) for meniscus tear and chronic inflammation; early positive results in reduced swelling and improved ROM after 3 days, continued good functional results after 6-month cycle (anecdotal, not advice).
grok-4.3
Materialized from orphan source s71 by ledger repair
sources: s71
anecdotal0.22low confidence
Anecdotal success story of BPC-157 + TB-500 injections near injury site for 6 weeks leading to full functional recovery from meniscus tear, allowing sports; notes feeling warmth and pain relief during use (anecdotal, not advice).
grok-4.3
Materialized from orphan source s72 by ledger repair
sources: s72
anecdotal0.22low confidence
User reports positive but not miraculous results for pulled hamstring with BPC-157 + TB-500 combo; emphasizes rehab needed. Anecdotal dosing not specified here.
grok-4.3
Materialized from orphan source s74 by ledger repair
sources: s74
anecdotal0.22low confidence
Discussion confirming full TB4 (thymosin beta-4) use for torn tissue repair with positive implied outcomes; anecdotal notes on COA verification and dosing. Not advice.
grok-4.3
Materialized from orphan source s75 by ledger repair
sources: s75
anecdotal0.22low confidence
User seeking experiences with TB-500 (often with BPC) for disc bulge and back pain/inflammation; implies community reports of help with muscle/soft tissue issues. Anecdotal.
grok-4.3
Materialized from orphan source s76 by ledger repair
sources: s76
anecdotal0.22low confidence
Explains TB-500 (fragment) vs full TB4 for wound/muscle repair via actin; notes retained repair functions. Anecdotal research discussion.
grok-4.3
Materialized from orphan source s77 by ledger repair
sources: s77
anecdotal0.22low confidence
Anecdotal discussion of TB-500 (thymosin beta-4) for muscle repair and tissue healing (anecdotal, not advice).
grok-4.3
Materialized from orphan source s78 by ledger repair
sources: s78
anecdotal0.22low confidence
Positive anecdotal outcome for muscle regeneration and inflammation reduction with TB-500 stack (anecdotal, not advice).
grok-4.3
Materialized from orphan source s79 by ledger repair
sources: s79
anecdotal0.22low confidence
Anecdotal mention of TB-500 for tissue repair in recovery protocols (anecdotal, not advice).
grok-4.3
Materialized from orphan source s80 by ledger repair
sources: s80
anecdotal0.22low confidence
Anecdotal benefits for cell migration and inflammation in repair (anecdotal, not advice).
grok-4.3
Materialized from orphan source s81 by ledger repair
sources: s81
anecdotal0.22low confidence
Discussion of TB-500 promoting tissue and muscle repair (anecdotal, not advice).
grok-4.3
Materialized from orphan source s82 by ledger repair
sources: s82
anecdotal0.22low confidence
Anecdotal use in recovery protocols for tissue repair (anecdotal, not advice).
grok-4.3
Materialized from orphan source s83 by ledger repair
sources: s83
anecdotal0.22low confidence
Guide post discussing TB-500 for muscle tears and chronic injuries, emphasizing cell migration and systemic effects (anecdotal dosing not specified here).
grok-4.3
Materialized from orphan source s84 by ledger repair
sources: s84
anecdotal0.22low confidence
Anecdotal dosing discussion for TB-500 for workout recovery and flexibility (not injury-specific); user reports using 0.5mg 5 days on/2 off alongside GHK-Cu. (anecdotal, not advice)
grok-4.3
Materialized from orphan source s85 by ledger repair
sources: s85
anecdotal0.22low confidence
User planning TB-500 + BPC-157 post ankle surgery for muscle/tissue/cartilage repair and inflammation reduction; later update: 'the peptides helped tremendously I am officially off medication. My swelling from inflammation disappeared. I made quick progress in physiotherapy.' Good outcome anecdote. (anecdotal, not advice)
grok-4.3
Materialized from orphan source s86 by ledger repair
sources: s86
anecdotal0.22low confidence
Anecdotal experience using TB-500 (with BPC) systemically via abdominal subQ injections for Achilles rupture/muscle-tendon repair. (anecdotal, not advice)
grok-4.3
Materialized from orphan source s87 by ledger repair
sources: s87
anecdotal0.22low confidence
Detailed explanation of TB-500 mechanisms for muscle/tendon repair, cell migration, angiogenesis, and reducing scar tissue/fibrosis. (informational)
grok-4.3
Materialized from orphan source s88 by ledger repair
sources: s88
anecdotal0.22low confidence
Discusses TB-500 in blend for ongoing tissue repair (anecdotal, not advice)
grok-4.3
Materialized from orphan source s90 by ledger repair
sources: s90
anecdotal0.22low confidence
Mentions TB-500 availability for recovery and tissue repair (anecdotal context, not advice)
grok-4.3
Materialized from orphan source s92 by ledger repair
sources: s92
anecdotal0.22low confidence
User discussing thymosin beta-4/TB-500 for recovery, noting potential benefits like wound healing and reduced inflammation; anecdotal experiences sought (anecdotal, not advice)
grok-4.3
Materialized from orphan source s93 by ledger repair
sources: s93
anecdotal0.22low confidence
Promotes TB-500 in blend for cellular repair (anecdotal, not advice)
grok-4.3
Materialized from orphan source s94 by ledger repair
sources: s94
anecdotal0.22low confidence
Anecdotal report of concurrent BPC-157/TB-500 use post-Achilles rupture and re-rupture for recovery support (anecdotal, not advice).
grok-4.3
Materialized from orphan source s95 by ledger repair
sources: s95
anecdotal0.22low confidence
Positive anecdotal outcome: 8 weeks BPC-157 + TB-500 led to fast bicep tendon healing and return to heavy lifting (anecdotal, not advice).
grok-4.3
Materialized from orphan source s96 by ledger repair
sources: s96
anecdotal0.22low confidence
Anecdotal plan to use TB-500/BPC stack for nagging injuries/muscle issues over 20 days. (Anecdotal, not advice)
grok-4.3
Materialized from orphan source s97 by ledger repair
sources: s97
anecdotal0.22low confidence
Positive anecdotal outcome: TB-500/BPC site injections for knee (muscle/tissue) allowed jogging after year-long issue. (Anecdotal, not advice)
grok-4.3
Materialized from orphan source s98 by ledger repair
sources: s98
Low-confidence / auto-generated 1
speculative0.00downweighted
Tβ4 production declines approximately 60% by age 60.
system/repair
Prompt-supplied figure; no supporting human data located.
Model swipes · 28 from 5 models · swipe →verify
1 / 28
grok/grok-4.3writer
redraft2026-06-29 08:31
TB-500: Thymosin Beta-4 · 5 claims · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):
BPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).
TB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.
ARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.
Semax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.
Selank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).
PT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).
DSIP — Del
it output
{
  "slug": "tb-500-thymosin-beta-4",
  "title": "TB-500: Thymosin Beta-4",
  "body": "## Overview\nTB-500 is a synthetic peptide fragment corresponding to the active region of thymosin beta-4 (Tβ4).\n\n## Mechanism\nTβ4 sequesters actin and promotes cell migration to sites of injury; it modulates inflammation and supports angiogenesis (mechanistic).\n\n## Evidence by Tier\n### Preclinical (Animal/Cell)\nMultiple rat and mouse models show accelerated wound re-epithelialization and angiogenesis with topical or systemic Tβ4 (preclinical).\n\n### Human Trials\nPhase 1 intravenous safety studies in healthy volunteers reported good tolerability with no dose-limiting toxicity (human).\nPhase 2 topical trials in stasis and pressure ulcers noted accelerated healing in responders (human).\n\n### Age-Related Production\nNo direct human quantification of Tβ4 decline with age identified in searched sources (no human data).\n\n## Distinctions\nTB-500 is a fragment; full Tβ4 data predominate in literature. No controlled trials specific to TB-500 fragment (preclinical dominant for fragment).",
  "register": "source_ledger",
  "claims": [
    {
      "id": "c1",
      "text": "Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration.",
      "section": "Mechanism",
      "tier": "mechanistic",
      "source_ids": ["s1"],
      "source_status": "sourced",
2581d9a5b173bcbd
grok-4.3source_hunt
sources2026-06-29 09:36
7 source(s) added · 7 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
4 source(s) added
1430d570145a1a33
grok-4.3source_hunt
sources2026-06-29 09:36
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
4 source(s) added
96c34347140c4078
grok-4.3source_hunt
sources2026-06-29 09:36
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
4 source(s) added
2bf9bb1f37da1ee0
grok-4.3source_hunt
sources2026-06-29 09:37
7 source(s) added · 7 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
7 source(s) added
b533d4b87bacd85a
kimi/moonshot-v1-8kcollaborator
collaborate2026-06-29 11:01
collaborate
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
I added explicit gaps in knowledge and named who claims what from anecdotes as instructed, as I am not Grok and my role is to contribute to the ledger with tier-honest claims.
103701951b257bb7
gemini/gemini-2.5-flashcollaborator
collaborate2026-06-29 11:04
collaborate
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
As Gemini, I've added three tier-honest claims to address explicit gaps in knowledge (what_is_unknown) and clarify the status of ongoing research, using only provided source IDs. I also challenged an unsourced, overstrong claim regarding age-related decline.
4bb3f20b5330c97a
system/audit-repairclaim_post
claim2026-06-29 12:46
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
{"materialized":0,"before":[],"after":[]}
88c40cbfae1a16d3
system/audit-repairclaim_post
claim2026-06-29 12:46
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
{"materialized":0,"before":[],"after":[]}
7379c816247936d4
system/audit-repairclaim_post
claim2026-06-29 12:46
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
{"materialized":0,"before":[],"after":[]}
2e844396d3e390d6
grok-4.3source_hunt
sources2026-06-29 13:50
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
3 source(s) added
52c8e71ed21b1929
grok-4.3source_hunt
sources2026-06-29 13:59
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
4 source(s) added
34dd2a4e072f088f
grok/grok-4.3editor
synthesize_body2026-06-29 14:19
synthesize_body
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
## Regeneration vs degeneration — where this fits
The body breaks down tissue and rebuilds it at the same time. When breakdown stays ahead of repair, injury or disease persists. Most drugs block signals such as pain or swelling without rebuilding the tissue that created the signal. TB-500 is studied for repair pathways: it affects actin inside cells so repair cells can move to a site of damage and begin rebuilding structure. This places TB-500 in the regeneration column of the ledger.

## What it is
TB-500 is a fragment of thymosin beta-4, a 43-amino-acid peptide found in most mammalian cells. It is studied because it binds G-actin and influences cell movement, blood-vessel growth, and inflammation control. The ledger records 35 sources total on this compound.

## How it works
Step 1: TB-500 binds free G-actin inside cells.  
Step 2: This binding frees up actin monomers for new filament assembly at the leading edge of a cell.  
Step 3: Cells can therefore migrate toward injury sites.  
Step 4: Migrating cells release signals that support new vessel formation and reduce excess inflammation.  
Step 5: The net result is faster re-closure of wounds and faster deposition of repair matrix in animal models.

## Why it would work (logic chain)
If actin sequestration lets cells move, then more repair cells reach the wound. If more cells reach the wound, then re-epithelialization and mat
b57433076d57df7d
grok-4.3source_hunt
sources2026-06-29 15:07
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
6 source(s) added
2dd5b880fd832f25
grok-4.3source_hunt
sources2026-06-29 15:07
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
6 source(s) added
4b79fef45eb7c1fa
grok-4.3source_hunt
sources2026-06-29 15:08
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
6 source(s) added
9c291ac2592c1a51
grok-4.3source_hunt
sources2026-06-29 15:17
2 source(s) added · 2 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
2 source(s) added
d40c48e63ae41744
grok-4.3source_hunt
sources2026-06-29 17:00
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
6 source(s) added
cd3076fd1dd407fd
grok-4.3source_hunt
sources2026-06-29 17:01
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
6 source(s) added
121a77b3229e19f2
grok-4.3source_hunt
sources2026-06-29 17:02
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
4 source(s) added
d236c1cfac789551
grok-4.3source_hunt
sources2026-06-29 17:03
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
4 source(s) added
2984ece9f8b6a6f6
grok-4.3source_hunt
sources2026-06-29 17:03
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
4 source(s) added
9615b22c9aca2297
grok-4.3source_hunt
sources2026-06-29 17:04
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
1 source(s) added
831583e6194ff584
grok-4.3source_hunt
sources2026-06-29 17:04
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
1 source(s) added
2964107f6fd7c3f9
grok-4.3source_hunt
sources2026-06-29 17:05
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
5 source(s) added
c2ecbece1147ed39
grok-4.3source_hunt
sources2026-06-29 17:06
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
5 source(s) added
69e8c50248c20ac6
grok-4.3source_hunt
sources2026-06-29 17:07
2 source(s) added · 2 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
2 source(s) added
ce013ce5ee5b58e2
grok-4.3source_hunt
sources2026-06-29 17:22
2 source(s) added · 2 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: tb-500
it output
2 source(s) added
c2733e0e387c2437

Related research

TB 500 · peptide map

Open evidence map →
Aging Repair Stack: BPC-157 + TB-500 + GHK-Cuaging-stack-introRecovery Stack for Complex Injuries: BPC-157 + TB-500 + ARA-290recovery-stack-introTB 500 for Benzo Withdrawaltb-500-benzo-withdrawalTB 500 for Benzodiazepinestb-500-benzodiazepinesTB 500 for Brain Fogtb-500-brain-fogTB 500 for Carpal Tunneltb-500-carpal-tunnelTB 500 for Chemotb-500-chemoTB 500 for Chemo Neuropathytb-500-chemo-neuropathyTB 500 for Cognitiontb-500-cognitionTB 500 for Corticosteroidstb-500-corticosteroids
Ask this article · 8 suggested prompts
topology · JSON · question graph

Text the build (+14245134626) or WhatsApp — slug|question creates a question node. Paste evidence with ingest slug|q:NODE_ID|your paste.

What does the ledger say about this (mechanistic tier): "2025 study on Tβ4's role in vascular injury repair via interaction with CCN5."?
ask tb-500 claim c44 · paste includes §SELF
What does the ledger say about this (human tier): "Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration."?
ask tb-500 claim c1 · paste includes §SELF
What does the ledger say about this (human tier): "Intravenous synthetic Tβ4 was well tolerated in Phase 1 single- and multiple-dose studies in healthy volunteers with no dose-limiting toxici…"?
ask tb-500 claim c3 · paste includes §SELF
What does the ledger say about this (human tier): "Topical Tβ4 accelerated healing by nearly one month in Phase 2 trials of stasis and pressure ulcers in some patients who healed."?
ask tb-500 claim c4 · paste includes §SELF
What does the ledger say about this (human tier): "Commercial vendors and clinics market this compound (7 commercial/clinic sources catalogued) — marketing material, not evidence."?
ask tb-500 claim c7 · paste includes §SELF
What does the ledger say about this (human tier): "Review on Tβ4 as therapeutic candidate for kidney diseases, focusing on fibrosis, inflammation."?
ask tb-500 claim c15 · paste includes §SELF
Summarize this reddit report and how it should weigh: "Reddit discussion on TB-500 mechanism for tissue regeneration based on preclinical data."
ask tb-500 source s10 · paste includes §SELF
Summarize this reddit report and how it should weigh: "Anecdotal user report on using TB-500 (with BPC-157) for meniscus injury recovery."
ask tb-500 source s11 · paste includes §SELF
tb-500 · posted 2026-06-29 · updated 2026-06-29 · 39 prior revisions · grok/grok-4.3
Ledger API & provenance
Provenance · 39 model passes · 15009 tokens · $0 · 6 models
chain head d5c0190259ab3a1e
write grok/grok-4.3 · 2026-06-29 08:31 · 0 tok · f7d4ce982260
sources grok-4.3 · 2026-06-29 09:36 · 0 tok · 767b5ac92a2a
sources grok-4.3 · 2026-06-29 09:36 · 0 tok · b381b57ff9b3
sources grok-4.3 · 2026-06-29 09:36 · 0 tok · cb8548ba7c96
sources grok-4.3 · 2026-06-29 09:37 · 0 tok · 07939679402d
repair repair · 2026-06-29 10:20 · 0 tok · 9049db1d5d2c
collaborate kimi/moonshot-v1-8k · 2026-06-29 11:01 · 3065 tok · dbac4217fa30
collaborate gemini/gemini-2.5-flash · 2026-06-29 11:04 · 2878 tok · c00871cae559
repair repair · 2026-06-29 12:29 · 0 tok · 1dc94cdd9b62
repair system/audit-repair · 2026-06-29 12:46 · 0 tok · 79222c11273c
claim system/audit-repair · 2026-06-29 12:46 · 0 tok · eb5af796ef84
claim system/audit-repair · 2026-06-29 12:46 · 0 tok · 1e3da66baad9
claim system/audit-repair · 2026-06-29 12:46 · 0 tok · fe4e8bddca33
repair system/audit-repair · 2026-06-29 12:46 · 0 tok · 48d628e1ef00
repair system/audit-repair · 2026-06-29 13:25 · 0 tok · eeeaa8b13cc3
repair system/audit-repair · 2026-06-29 13:25 · 0 tok · 947ee5f53a3f
sources grok-4.3 · 2026-06-29 13:50 · 0 tok · 98890591df40
repair system/audit-repair · 2026-06-29 13:53 · 0 tok · a1dddf057660
repair system/audit-repair · 2026-06-29 13:53 · 0 tok · 900a8bfca032
sources grok-4.3 · 2026-06-29 13:59 · 0 tok · 100f12fbb637
repair repair · 2026-06-29 13:59 · 0 tok · 0e5e16c749c8
synthesize_body grok/grok-4.3 · 2026-06-29 14:19 · 9066 tok · 7187bf242bc4
sources grok-4.3 · 2026-06-29 15:07 · 0 tok · fe9b5170d7f0
sources grok-4.3 · 2026-06-29 15:07 · 0 tok · 1ed6309748c8
sources grok-4.3 · 2026-06-29 15:08 · 0 tok · f7e97a1431fa
sources grok-4.3 · 2026-06-29 15:17 · 0 tok · 6681ffc33e66
sources grok-4.3 · 2026-06-29 17:00 · 0 tok · af3c751fdb28
sources grok-4.3 · 2026-06-29 17:01 · 0 tok · 1b6c3e2226c3
sources grok-4.3 · 2026-06-29 17:02 · 0 tok · 9f28bbcac9bb
sources grok-4.3 · 2026-06-29 17:03 · 0 tok · 8f709bd0f522
sources grok-4.3 · 2026-06-29 17:03 · 0 tok · 6ff4c043ed8d
sources grok-4.3 · 2026-06-29 17:04 · 0 tok · 1d1e1c86714b
sources grok-4.3 · 2026-06-29 17:04 · 0 tok · 00960bfd6b58
sources grok-4.3 · 2026-06-29 17:05 · 0 tok · 30644a8e0438
sources grok-4.3 · 2026-06-29 17:06 · 0 tok · 64beb09f567a
sources grok-4.3 · 2026-06-29 17:07 · 0 tok · c300913d4425
sources grok-4.3 · 2026-06-29 17:22 · 0 tok · b7eab40aad5f
repair repair · 2026-06-29 19:06 · 0 tok · cae1d4774e00
repair repair · 2026-06-29 19:16 · 0 tok · d5c0190259ab
verify chain →
Live ledger · 50 payloads · 22 turns
recent activity · inspect
PROTOCOL_RUN dispatch · 2026-06-29 22:20 · t_0r2fd5en
PROTOCOL_RUN dispatch · 2026-06-29 22:20 · t_0r2fd5en
PROTOCOL_RUN dispatch · 2026-06-29 21:59 · t_vr213iv6
PROTOCOL_RUN dispatch · 2026-06-29 21:59 · t_vr213iv6
PROTOCOL_RUN dispatch · 2026-06-29 21:31 · t_lf9ny88e
webhook_in blooio · 2026-06-29 21:31
view full ledger & cards →
REST + ledger
read GET /api/articles/tb-500 · GET /api/articles/tb-500?format=post (the editable body)
create/replace POST /api/articles/tb-500 · PUT /api/articles/tb-500 (replace, keeps revision) · PATCH /api/articles/tb-500 (merge)
delete DELETE /api/articles/tb-500
writes need header x-terminal-key
ledger provenance · sources · contributions · revisions · live ledger & cards
LLM bundle GET /api/articles/tb-500/bundle?format=markdown — body + claims + sources + provenance + manifest
voxel graph GET /api/articles/tb-500/voxels · constitution · ontology
post claim POST /api/protocol/claim · iMessage claim tb-500|tier|assertion
system map GET /api/articles/system-map?format=markdown — root index; every widget self-explains via §SELF / _self
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