Evidence review

PT-141: Brain-Level Arousal

#peptide#pt-141
bundle · json · system map · manifest

Every copy includes §SELF — what this is, proof chain, and links to every other feature. No context required.

§SELF — this page explains the system
## §SELF — miscsubjects (paste without context)

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `human_page` — **Human article page**
Rendered article with claims, sources, copy widgets, ask prompts.
- **article slug:** `pt-141`
- **contains:** rendered article, copy widgets, claims, sources, ask prompts
- **how to use:** Use Copy for LLM or Copy system map — both paste without context.
- **read:** https://miscsubjects.com/a/pt-141

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/pt-141/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **bundle** — Paste-ready package: body + claims + sources + voxels + provenance + manifest + constitution. · https://miscsubjects.com/api/articles/pt-141/bundle?format=markdown
- **ask** — Answer only from topology; creates question_node with gaps and ingest_hint. · https://miscsubjects.com/api/articles/pt-141/prompts
- **topology** — Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER. · https://miscsubjects.com/api/articles/pt-141/topology

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

*Not medical advice. Tier-honest. Cite claim/source ids.*

Regeneration vs degeneration — where this fits

The body is always doing two things at once: breaking down (degeneration) and building back (regeneration). A condition persists when breakdown outruns repair. Most drugs used for symptoms suppress a signal (pain, acid, anxiety, inflammation) without fixing the tissue that caused the signal. Peptides in this ledger are studied for repair pathways: new blood vessels, repair-cell migration, nerve regrowth, gut lining, neural connections. This article maps one compound through that frame — what it is, how it is proposed to work, what evidence exists, and what people report.

What it is

Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only. In two identical phase 3 randomized double-blind placebo-controlled trials (RECONNECT), subcutaneous bremelanotide 1.75 mg as needed produced statistically significant increases in Female Sexual Function Index-desire domain scores and reductions in Female Sexual Distress Scale scores versus placebo in premenopausal women with hypoactive sexual desire disorder.

How it works

Step logic:

  1. Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
  2. 2025 narrative review on IV peptides including PT-141 for ED, noting central CNS activation mechanism and need for more trials.
  3. Long-term extension study data on bremelanotide safety and efficacy.
  4. 2025 study using hamster model to investigate bremelanotide's neurobiological mechanism; finds it does not act on VTA-NAc reward circuit or enhance sexual reward.
  5. PT-141 (bremelanotide) is a melanocortin receptor agonist that activates central nervous system pathways for sexual arousal signaling.
  6. 2022 review on neurobiological mechanism of bremelanotide via MC4R and dopamine in HSDD.
  7. Animal studies indicate melanocortin receptor activation in hypothalamic regions linked to sexual behavior.
  8. 2025 YouTube video guide covering PT-141 mechanism, applications, benefits, risks, and dosing.

Why it would work (logic chain)

  1. IF Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  2. IF 2025 narrative review on IV peptides including PT-141 for ED, noting central CNS activation mechanism and need for more trials. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  3. IF Long-term extension study data on bremelanotide safety and efficacy. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  4. IF 2025 study using hamster model to investigate bremelanotide's neurobiological mechanism; finds it does not act on VTA-NAc reward circuit or enhance sexual reward. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  5. IF PT-141 (bremelanotide) is a melanocortin receptor agonist that activates central nervous system pathways for sexual arousal signaling. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  6. IF 2022 review on neurobiological mechanism of bremelanotide via MC4R and dopamine in HSDD. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).

Why people take it

Reasons that appear in this ledger:

  1. Anecdotal/promotional post highlighting PT-141's central mechanism for sexual desire.
  2. User reports no effects even at high dose, suspects product is ineffective or fake.
  3. Mixed anecdotal: found it 'fun' but not worthwhile due to lack of personal need and cost.
  4. Summary of effects including modest libido boost and common nausea side effect.
  5. Promotes combination product with user-implied positive libido outcomes for women.
  6. User endorsement of PT-141 for strong erections and mental arousal, especially stacked.
  7. User reports stronger nausea with PT-141 compared to MT2 despite ramping dose.
  8. User reports nausea at 1mg injectable but oral 2.5mg version had no effect.
  9. Anecdotal positive: euphoric effects, frequent erections at 750mcg male/1.5mg female doses; minor downside noted. Not advice.
  10. Mentions approved use for female HSDD alongside other drugs; no personal anecdotes.

How many people take it

There is no reliable global count of how many people take this compound. That number is not in this ledger.

What we can count from this ledger:

  • 68 anecdote source(s) (posts, threads, comments)
  • 69 anecdote-tier claim(s) derived from them

Logic: 68 online report(s) are catalogued here. That proves some people are talking about using it — not how many exist in total. Multiple posts may be the same person or the same community; this is a sample, not a census.

Evidence inventory

This is a count of what is in this ledger — not a claim about all research worldwide.

  • Scientific sources catalogued (PubMed, trials, reviews): 31
  • Claims tagged human evidence: 17
  • Claims tagged preclinical (animal/lab): 0
  • Claims tagged anecdotal: 69
  • Reddit posts catalogued: 46
  • X posts catalogued: 19
  • Other anecdote sources (YouTube, Instagram, etc.): 3
  • Total sources in chain: 101

Quantified confidence (this ledger): 0.95 / 1.00 — moderate — human claims present in ledger

Formula: human claims×0.12 + preclinical×0.04 + anecdote×0.015 + studies (capped). This is not clinical certainty — it measures how much graded evidence is catalogued here.

What scientists say

Bremelanotide: Uses, Interactions, Mechanism of Action (source s1)

Mechanism described as melanocortin agonist with central action.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder (source s2)

Phase 3 RECONNECT trial results with specific efficacy metrics.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

VYLEESI (bremelanotide injection) Prescribing Information (source s3)

FDA approval label confirming indication.

Evidence type: Published research.

Melanocortin Receptors, Melanotropic Peptides and Penile Erection (source s4)

Preclinical mechanistic discussion of central melanocortin pathways.

Evidence type: Published research.

Study to Evaluate the Efficacy/Safety of Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder (source s7)

Details on phase 3 trial (RECONNECT) for bremelanotide in HSDD, including open-label extension.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Bremelanotide (subcutaneous route) - Side effects & dosage (source s9)

Mayo Clinic overview of bremelanotide (Vyleesi) for HSDD, updated as of 2026.

Evidence type: Published research.

The neurobiology of bremelanotide for the treatment of hypoactive sexual desire disorder in premenopausal women (source s10)

2022 review on neurobiological mechanism of bremelanotide via MC4R and dopamine in HSDD.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Bremelanotide for Treatment of Female Hypoactive Sexual Desire Disorder (source s12)

2022 review summarizing clinical evidence for bremelanotide in HSDD treatment.

Evidence type: Published research.

PT-141: a melanocortin agonist for the treatment of sexual dysfunction (source s13)

2003 PubMed abstract on early PT-141 trials for ED.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder (source s14)

Long-term extension study data on bremelanotide safety and efficacy.

Evidence type: Published research.

A Phase 2 Study Evaluating the Co-Administration of Bremelanotide With a PDE5 Inhibitor for the Treatment of Erectile Dysfunction (source s15)

Ongoing or recent Phase 2 trial for bremelanotide + PDE5i in men with ED.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

A Phase 3, Bridging, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Subcutaneously Administered Bremelanotide in Premenopausal Women with Hypoactive Sexual Desire Disorder (source s16)

Phase 3 bridging study for bremelanotide in HSDD.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

PT-141 for Men - Los Angeles (source s17)

Urology clinic overview of PT-141 use for male sexual health, published 2025.

Evidence type: Published research.

Bremelanotide for Hypoactive Sexual Desire Disorder (source s27)

2024 analysis questioning the clinical significance of bremelanotide for HSDD.

Evidence type: Published research.

PT 141 Peptide (Bremelanotide): Benefits, Dosage & Nasal Spray (source s30)

June 2026 medical site overview of PT-141 uses and references to trials.

Evidence type: Published research.

PT-141 Peptide: What It Is, How It Works, and Safety Info (source s31)

June 2026 article summarizing PT-141 evidence and placebo effects.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Female Syrian hamster analyses of bremelanotide, a US FDA approved drug for the treatment of female hypoactive sexual desire disorder (source s32)

2025 study using hamster model to investigate bremelanotide's neurobiological mechanism; finds it does not act on VTA-NAc reward circuit or enhance sexual reward.

Evidence type: Published research.

Intravenous peptides and amino acids for erectile dysfunction: a narrative review of current applications and future directions (source s33)

2025 narrative review on IV peptides including PT-141 for ED, noting central CNS activation mechanism and need for more trials.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

What people say on Reddit

PT-141 Experience - it absolutely works — Reddit, r/erectiledysfunction (source s5)

User reports positive experience with PT-141 for ED, discusses administration and compares to Vyleesi.

PT 141 for libido — Reddit, r/Biohackers (source s6)

Discussion on PT-141 (bremelanotide) for libido enhancement in men, dosing advice, and comparison to Vyleesi.

Taken PT-141 twice now and I am happily amazed — Reddit, r/erectiledysfunction (source s18)

User anecdote on positive ED and libido effects with PT-141 dosing details and side effects noted.

The combo of Tadalafil and PT-141 is insanely effective — Reddit, r/erectiledysfunction (source s21)

User reports strong positive effects on erections and arousal from PT-141 alone and especially combined with tadalafil; notes mild nausea/flushing as side effects.

My PT-141 experience — Reddit, r/Swingers (source s22)

Positive user experience with prolonged robust erections lasting up to 48 hours without pain.

PT-141: Game-Changer or Overrated? Need Real ... — Reddit, r/Biohackers (source s23)

Negative report emphasizing side effects like nausea, flushing, and prolonged sensations outweighing benefits.

PT-141 — Reddit, r/Swingers (source s26)

Discusses common nausea side effect and extreme overdose anecdote with prolonged erection.

PT-141 (bremelanotide): the sexual health peptide that isn't talked about enough — Reddit, r/NTNPerformance (source s28)

Recent user discussion explaining PT-141 mechanism and use.

what PT-141 actually does for sexual desire — Reddit, r/NTNPerformance (source s29)

2025 Reddit post detailing PT-141's effects on libido via MC4R.

PT-141 vs Melanotan-2 — Which One Boosts Sex Drive? — Reddit, r/BodyHackGuide (source s38)

User discussion comparing PT-141 and MT2 for libido effects, with anecdotal experiences and explanations of mechanisms.

PT-141 / Oxytocin Nasal Spray: Research Guide — Reddit, r/USPeptides (source s39)

Reddit post providing research guide on combined PT-141 and oxytocin nasal spray for sexual health.

Our first experience with PT-141 — Reddit, r/SEXONDRUGS (source s41)

User reports delayed onset with no strong libido boost but eventual activity; mixed outcome.

PT141: risks and dangers — Reddit, r/SEXONDRUGS (source s42)

Negative experience: nausea, bloating, no libido increase or opposite effect.

How many have tried PT 141? Does it work ? — Reddit, r/Swingers (source s43)

Positive user report on erections and libido at 1.5mg dose; headache at higher dose.

First experience with PT-141 (Bremelanotide) — Reddit, r/SEXONDRUGS (source s44)

Mild side effects reported with first use; implies positive sexual effects context.

Your Full PT-141 Mini Guide in 2026 (Benefits, Side Effects ...) — Reddit, r/BiohackingU (source s55)

2026 Reddit guide and user-oriented discussion on PT-141 benefits and side effects.

What people say on X

X post on PT-141 — X (source s11)

Anecdotal/promotional post highlighting PT-141's central mechanism for sexual desire.

X post about PT-141 bunk experience — X (source s24)

User reports no effects even at high dose, suspects product is ineffective or fake.

X post on peptide experiences including PT-141 — X (source s25)

Mixed anecdotal: found it 'fun' but not worthwhile due to lack of personal need and cost.

Bremelanotide (PT-141) post on X — X (source s35)

X post promoting PT-141 for libido and sexual health.

Peptide note: PT-141 (Bremelanotide) — X (source s45)

Summary of effects including modest libido boost and common nausea side effect.

X post by Inner Balance — X (source s62)

Promotes combination product with user-implied positive libido outcomes for women.

X post by AntiDoc — X (source s63)

User endorsement of PT-141 for strong erections and mental arousal, especially stacked.

X post about PT-141 nausea ramp up — X (source s64)

User reports stronger nausea with PT-141 compared to MT2 despite ramping dose.

X post oral PT-141 — X (source s65)

User reports nausea at 1mg injectable but oral 2.5mg version had no effect.

PT-141 and oxytocin combination experience — X (source s82)

Positive anecdotal report on PT-141 for arousal/erections, enhanced when combined with oxytocin.

PT-141 dosing anecdote — X (source s85)

Anecdotal positive: euphoric effects, frequent erections at 750mcg male/1.5mg female doses; minor downside noted. Not advice.

PT-141/Vyleesi for HSDD — X (source s86)

Mentions approved use for female HSDD alongside other drugs; no personal anecdotes.

PT-141 effect mention — X (source s87)

Brief positive anecdotal reference to strong effect of PT-141.

PT-141 prescription mention — X (source s88)

Anecdotal mention of doctor prescribing PT-141 (Vyleesi).

PT-141 suggestion — X (source s89)

Anecdotal suggestion of PT-141 for a condition (anecdotal, not advice).

pt-141 part 2 dosing update — X (source s93)

Anecdotal dosing log for PT-141 (500mcg male, 1.5mg female), seeking effects on libido (anecdotal, not advice).

Other anecdote evidence

PT-141 Myths Busted! The Truth About This Game-Changing Sex Peptide — YouTube (source s19)

Podcast/video discussing PT-141 myths, uses for men/women, comparison to ED drugs.

Can a simple PT-141 Nasal Spray make you a ROCKSTAR in ... — YouTube (source s46)

User (and wife) reports strong positive effects like teenage drive and long duration; nasal less effective than injectable.

PT-141 (Bremelanotide): A Comprehensive Guide to Treating Sexual Dysfunction — YouTube (source s56)

2025 YouTube video guide covering PT-141 mechanism, applications, benefits, risks, and dosing.

What we do not know

  1. There is a lack of long-term safety data on the use of PT-141 for brain-level arousal.

Safety and limits

  1. Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.

---

Not medical advice. Counts and quotes are from this article's hash-chained ledger. Anecdote = real reports, not proof. Animal studies ≠ human proof.

PT 141 · peptide map

Evidence map

Hover a node — its path lights up. Click to open the article.

Full map →
JumpPT-141 (Bremelanotide) and Sexual Dysfunction in the Context of Blood… · 8 humanPT 141 for Benzo WithdrawalPT 141 for BenzodiazepinesPT 141 for Brain Fog
Evidence · 101 sources · swipe →chain e6bf442b8238 · verify chain · provenance
1 / 101
Evidence ledger 97 · tier-ranked · API
mechanistic
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
human
In two identical phase 3 randomized double-blind placebo-controlled trials (RECONNECT), subcutaneous bremelanotide 1.75 mg as needed produced statistically significant increases in Female Sexual Function Index-desire domain scores and reductions in Female Sexual Distress Scale scores versus placebo in premenopausal women with hypoactive sexual desire disorder.
sources: s2
human
Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
human
2003 PubMed abstract on early PT-141 trials for ED.
sources: s13
human
2025 narrative review on IV peptides including PT-141 for ED, noting central CNS activation mechanism and need for more trials.
sources: s33
86 more ranked claims
human0.80
2024 company update on upcoming 2025 bremelanotide + PDE5i trials for ED.
grok/grok-4.3
Materialized from orphan source s50 by ledger repair
sources: s50
system0.35
PT-141: Brain-Level Arousal is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.
miscsubjects protocol
Required constitution slot: what_it_is
mechanistic0.30
Long-term extension study data on bremelanotide safety and efficacy.
grok/grok-4.3
Materialized from orphan source s14 by ledger repair
sources: s14
mechanistic0.30
2025 study using hamster model to investigate bremelanotide's neurobiological mechanism; finds it does not act on VTA-NAc reward circuit or enhance sexual reward.
grok/grok-4.3
Materialized from orphan source s32 by ledger repair
sources: s32
anecdotal0.30
Anecdotal/promotional post highlighting PT-141's central mechanism for sexual desire.
grok/grok-4.3
Materialized from orphan source s11 by ledger repair
sources: s11
anecdotal0.30
User reports no effects even at high dose, suspects product is ineffective or fake.
grok/grok-4.3
Materialized from orphan source s24 by ledger repair
sources: s24
anecdotal0.30
Mixed anecdotal: found it 'fun' but not worthwhile due to lack of personal need and cost.
grok/grok-4.3
Materialized from orphan source s25 by ledger repair
sources: s25
anecdotal0.30
Summary of effects including modest libido boost and common nausea side effect.
grok/grok-4.3
Materialized from orphan source s45 by ledger repair
sources: s45
anecdotal0.30
Promotes combination product with user-implied positive libido outcomes for women.
grok/grok-4.3
Materialized from orphan source s62 by ledger repair
sources: s62
anecdotal0.30
User endorsement of PT-141 for strong erections and mental arousal, especially stacked.
grok/grok-4.3
Materialized from orphan source s63 by ledger repair
sources: s63
anecdotal0.30
User reports stronger nausea with PT-141 compared to MT2 despite ramping dose.
grok-4.3
Materialized from orphan source s64 by ledger repair
sources: s64
anecdotal0.30
User reports nausea at 1mg injectable but oral 2.5mg version had no effect.
grok-4.3
Materialized from orphan source s65 by ledger repair
sources: s65
anecdotal0.30
Anecdotal positive: euphoric effects, frequent erections at 750mcg male/1.5mg female doses; minor downside noted. Not advice.
grok-4.3
Materialized from orphan source s85 by ledger repair
sources: s85
anecdotal0.30
Mentions approved use for female HSDD alongside other drugs; no personal anecdotes.
grok-4.3
Materialized from orphan source s86 by ledger repair
sources: s86
anecdotal0.30
Brief positive anecdotal reference to strong effect of PT-141.
grok-4.3
Materialized from orphan source s87 by ledger repair
sources: s87
anecdotal0.30
Anecdotal suggestion of PT-141 for a condition (anecdotal, not advice).
grok-4.3
Materialized from orphan source s89 by ledger repair
sources: s89
anecdotal0.30
Anecdotal dosing log for PT-141 (500mcg male, 1.5mg female), seeking effects on libido (anecdotal, not advice)
grok-4.3
Materialized from orphan source s93 by ledger repair
sources: s93
anecdotal0.30
Brief anecdotal positive reaction to first use of PT-141.
grok-4.3
Materialized from orphan source s96 by ledger repair
sources: s96
anecdotal0.30
Anecdotal medical prescription for Vyleesi/PT-141 (anecdotal, not advice).
grok-4.3
Materialized from orphan source s101 by ledger repair
sources: s101
human0.22low confidence
PT-141 (bremelanotide) is a synthetic melanocortin receptor agonist that activates central nervous system pathways for sexual arousal signaling.
system/unknown
Core mechanism definition matching provided peptide entry.
sources: s1
human0.22
Details on phase 3 trial (RECONNECT) for bremelanotide in HSDD, including open-label extension.
grok/grok-4.3
Materialized from orphan source s7 by ledger repair
sources: s7
human0.22low confidence
2022 review on neurobiological mechanism of bremelanotide via MC4R and dopamine in HSDD.
grok/grok-4.3
Materialized from orphan source s10 by ledger repair
sources: s10
human0.22
Ongoing or recent Phase 2 trial for bremelanotide + PDE5i in men with ED.
grok/grok-4.3
Materialized from orphan source s15 by ledger repair
sources: s15
human0.22
Phase 3 bridging study for bremelanotide in HSDD.
grok/grok-4.3
Materialized from orphan source s16 by ledger repair
sources: s16
human0.22
June 2026 article summarizing PT-141 evidence and placebo effects.
grok/grok-4.3
Materialized from orphan source s31 by ledger repair
sources: s31
human0.22low confidence
2026 review questioning potential use of bremelanotide (PT-141) for male sexual arousal/desire disorders.
grok/grok-4.3
Materialized from orphan source s47 by ledger repair
sources: s47
human0.22low confidence
2026 review includes bremelanotide as a therapeutic peptide for sexual function in aging/gerontology context.
grok/grok-4.3
Materialized from orphan source s48 by ledger repair
sources: s48
human0.22low confidence
2025 review on pharmacologic treatments for FSD/HSDD including bremelanotide.
grok/grok-4.3
Materialized from orphan source s49 by ledger repair
sources: s49
human0.22low confidence
2023 review assessing safety and efficacy of bremelanotide for HSDD.
grok/grok-4.3
Materialized from orphan source s52 by ledger repair
sources: s52
human0.22
Discusses recent observational data and ongoing trials for PT-141 in men with ED.
grok/grok-4.3
Materialized from orphan source s54 by ledger repair
sources: s54
human0.22low confidence
There is a lack of long-term safety data on the use of PT-141 for brain-level arousal.
kimi-collaborator
This claim addresses an explicit gap in the ledger regarding long-term safety, which is a significant aspect of understanding any medical intervention.
sources: s1
mechanistic0.22low confidence
Animal studies indicate melanocortin receptor activation in hypothalamic regions linked to sexual behavior.
system/unknown
Explicit separation of rat/animal data from human trials.
sources: s4
anecdotal0.22low confidence
User reports positive experience with PT-141 for ED, discusses administration and compares to Vyleesi.
grok/grok-4.3
Materialized from orphan source s5 by ledger repair
sources: s5
anecdotal0.22low confidence
Discussion on PT-141 (bremelanotide) for libido enhancement in men, dosing advice, and comparison to Vyleesi.
grok/grok-4.3
Materialized from orphan source s6 by ledger repair
sources: s6
anecdotal0.22low confidence
User anecdote on positive ED and libido effects with PT-141 dosing details and side effects noted.
grok/grok-4.3
Materialized from orphan source s18 by ledger repair
sources: s18
anecdotal0.22low confidence
Podcast/video discussing PT-141 myths, uses for men/women, comparison to ED drugs.
grok/grok-4.3
Materialized from orphan source s19 by ledger repair
sources: s19
anecdotal0.22low confidence
User reports strong positive effects on erections and arousal from PT-141 alone and especially combined with tadalafil; notes mild nausea/flushing as side effects.
grok/grok-4.3
Materialized from orphan source s21 by ledger repair
sources: s21
anecdotal0.22low confidence
Positive user experience with prolonged robust erections lasting up to 48 hours without pain.
grok/grok-4.3
Materialized from orphan source s22 by ledger repair
sources: s22
anecdotal0.22low confidence
Negative report emphasizing side effects like nausea, flushing, and prolonged sensations outweighing benefits.
grok/grok-4.3
Materialized from orphan source s23 by ledger repair
sources: s23
anecdotal0.22low confidence
Discusses common nausea side effect and extreme overdose anecdote with prolonged erection.
grok/grok-4.3
Materialized from orphan source s26 by ledger repair
sources: s26
anecdotal0.22low confidence
Recent user discussion explaining PT-141 mechanism and use.
grok/grok-4.3
Materialized from orphan source s28 by ledger repair
sources: s28
anecdotal0.22low confidence
2025 Reddit post detailing PT-141's effects on libido via MC4R.
grok/grok-4.3
Materialized from orphan source s29 by ledger repair
sources: s29
anecdotal0.22low confidence
X post promoting PT-141 for libido and sexual health.
grok/grok-4.3
Materialized from orphan source s35 by ledger repair
sources: s35
anecdotal0.22low confidence
User discussion comparing PT-141 and MT2 for libido effects, with anecdotal experiences and explanations of mechanisms.
grok/grok-4.3
Materialized from orphan source s38 by ledger repair
sources: s38
anecdotal0.22low confidence
Reddit post providing research guide on combined PT-141 and oxytocin nasal spray for sexual health.
grok/grok-4.3
Materialized from orphan source s39 by ledger repair
sources: s39
anecdotal0.22low confidence
User reports delayed onset with no strong libido boost but eventual activity; mixed outcome.
grok/grok-4.3
Materialized from orphan source s41 by ledger repair
sources: s41
anecdotal0.22low confidence
Negative experience: nausea, bloating, no libido increase or opposite effect.
grok/grok-4.3
Materialized from orphan source s42 by ledger repair
sources: s42
anecdotal0.22low confidence
Positive user report on erections and libido at 1.5mg dose; headache at higher dose.
grok/grok-4.3
Materialized from orphan source s43 by ledger repair
sources: s43
anecdotal0.22low confidence
Mild side effects reported with first use; implies positive sexual effects context.
grok/grok-4.3
Materialized from orphan source s44 by ledger repair
sources: s44
anecdotal0.22low confidence
User (and wife) reports strong positive effects like teenage drive and long duration; nasal less effective than injectable.
grok/grok-4.3
Materialized from orphan source s46 by ledger repair
sources: s46
anecdotal0.22low confidence
2026 Reddit guide and user-oriented discussion on PT-141 benefits and side effects.
grok/grok-4.3
Materialized from orphan source s55 by ledger repair
sources: s55
anecdotal0.22low confidence
2025 YouTube video guide covering PT-141 mechanism, applications, benefits, risks, and dosing.
grok/grok-4.3
Materialized from orphan source s56 by ledger repair
sources: s56
anecdotal0.22low confidence
Discusses real-world user benefits for libido/ED in men and women, plus side effects.
grok/grok-4.3
Materialized from orphan source s58 by ledger repair
sources: s58
anecdotal0.22low confidence
User reports on PT-141 for low libido and psychological ED, seeking weaning advice.
grok/grok-4.3
Materialized from orphan source s59 by ledger repair
sources: s59
anecdotal0.22low confidence
Thread with user questions and references to experiences with PT-141.
grok/grok-4.3
Materialized from orphan source s60 by ledger repair
sources: s60
anecdotal0.22low confidence
Mixed user report: limited libido effect but some erection changes after multiple uses.
grok/grok-4.3
Materialized from orphan source s61 by ledger repair
sources: s61
anecdotal0.22low confidence
Anecdotal reports of PT-141's effects on brain-level arousal vary widely, indicating a need for more consistent and rigorous data collection.
kimi-collaborator
This claim fills a gap by summarizing the anecdotal claims from the sources s5 and s6, which are individual user experiences that contribute to the overall understanding of the topic.
sources: s5, s6
anecdotal0.22low confidence
User reports successful combo with Cialis, no libido boost for wife.
grok-4.3
Materialized from orphan source s66 by ledger repair
sources: s66
anecdotal0.22low confidence
User reports PT-141 (1mg) restores spontaneous erections from thoughts after years of failure with Viagra; no side effects noted; timing takes ~8 hours.
grok-4.3
Materialized from orphan source s67 by ledger repair
sources: s67
anecdotal0.22low confidence
Another user shares dosing at 1mg, effects onset 5-6 hours, optimal after 11-12 hours, lasting ~12 more hours; good for multiple rounds.
grok-4.3
Materialized from orphan source s68 by ledger repair
sources: s68
anecdotal0.22low confidence
Community post discussing common nausea side effect and anecdotal prevention strategies like low starting dose, antihistamines, hydration, light meals.
grok-4.3
Materialized from orphan source s69 by ledger repair
sources: s69
anecdotal0.22low confidence
User reports strong positive sexual outcomes for wife when nausea/headache absent; implies side effects limit use.
grok-4.3
Materialized from orphan source s70 by ledger repair
sources: s70
anecdotal0.22low confidence
Negative long-term outcome: persistent anhedonia/depression after single use, compared to PSSD.
grok-4.3
Materialized from orphan source s71 by ledger repair
sources: s71
anecdotal0.22low confidence
User describes flushing and mild headache alongside implied positive effects.
grok-4.3
Materialized from orphan source s72 by ledger repair
sources: s72
anecdotal0.22low confidence
Positive ED/libido help post-Covid with only mild brief nausea.
grok-4.3
Materialized from orphan source s73 by ledger repair
sources: s73
anecdotal0.22low confidence
User reports strong positive first experience with PT-141 but second dose ineffective; discussion on dosing frequency.
grok-4.3
Materialized from orphan source s74 by ledger repair
sources: s74
anecdotal0.22low confidence
Female user reports nausea, headache, and no libido benefit from multiple PT-141 doses.
grok-4.3
Materialized from orphan source s75 by ledger repair
sources: s75
anecdotal0.22low confidence
61-year-old male reports PT-141 as a game changer for libido and performance for himself and partner.
grok-4.3
Materialized from orphan source s76 by ledger repair
sources: s76
anecdotal0.22low confidence
Detailed positive user report of intense youthful libido and sensitivity with minimal side effects (flushing, random erections).
grok-4.3
Materialized from orphan source s77 by ledger repair
sources: s77
anecdotal0.22low confidence
Positive user report of strong arousal and libido boost with mild short side effects; dosing 1mg as needed.
grok-4.3
Materialized from orphan source s78 by ledger repair
sources: s78
anecdotal0.22low confidence
Mixed: some libido/dryness help but bad side effects like flushing and skin darkening.
grok-4.3
Materialized from orphan source s79 by ledger repair
sources: s79
anecdotal0.22low confidence
Strong positive female experience with intense prolonged arousal effects.
grok-4.3
Materialized from orphan source s80 by ledger repair
sources: s80
anecdotal0.22low confidence
Negative experience: no libido benefit, side effects of congestion and dry mouth.
grok-4.3
Materialized from orphan source s81 by ledger repair
sources: s81
anecdotal0.22low confidence
Positive anecdotal report on PT-141 for arousal/erections, enhanced when combined with oxytocin.
grok-4.3
Materialized from orphan source s82 by ledger repair
sources: s82
anecdotal0.22low confidence
Anecdotal guide on PT-141 dosing (start 0.5-1mg), effects (desire boost, not like Viagra), sides (nausea, flushing); labels as research discussion only, not advice. Good outcomes: increased desire; bad: dose-dependent nausea.
grok-4.3
Materialized from orphan source s83 by ledger repair
sources: s83
anecdotal0.22low confidence
Anecdotal report of negative outcome: severe anhedonia from low dose PT-141; user questions safety for dopamine.
grok-4.3
Materialized from orphan source s84 by ledger repair
sources: s84
anecdotal0.22low confidence
Anecdotal mention of doctor prescribing PT-141 (Vyleesi).
grok-4.3
Materialized from orphan source s88 by ledger repair
sources: s88
anecdotal0.22low confidence
Informational thread on PT-141 mechanism and use with community discussion (anecdotal dosing/sides mentioned in comments).
grok-4.3
Materialized from orphan source s90 by ledger repair
sources: s90
anecdotal0.22low confidence
Anecdotal experience report with nasal PT-141 dosing and effects/sides (anecdotal, not advice).
grok-4.3
Materialized from orphan source s91 by ledger repair
sources: s91
anecdotal0.22low confidence
Users sharing recent anecdotes on PT-141 for sexual issues including potential side effects and dosing (anecdotal, not advice)
grok-4.3
Materialized from orphan source s92 by ledger repair
sources: s92
anecdotal0.22low confidence
Guide thread with user discussions on benefits, side effects like flushing/nausea, and real-world dosing anecdotes (anecdotal)
grok-4.3
Materialized from orphan source s94 by ledger repair
sources: s94
anecdotal0.22low confidence
Anecdotal dosing info: 1-3mg typical, personal 2mg effective with minimal sides (anecdotal, not advice).
grok-4.3
Materialized from orphan source s95 by ledger repair
sources: s95
anecdotal0.22low confidence
Anecdotal mention of PT-141 as part of a personal peptide regimen.
grok-4.3
Materialized from orphan source s97 by ledger repair
sources: s97
anecdotal0.22low confidence
Summary of study findings on PT-141 (bremelanotide) for female sexual arousal/orgasm.
grok-4.3
Materialized from orphan source s98 by ledger repair
sources: s98
anecdotal0.22low confidence
User seeking dosing advice due to fear of nausea side effect for self and partner (anecdotal discussion).
grok-4.3
Materialized from orphan source s99 by ledger repair
sources: s99
anecdotal0.22low confidence
Anecdotal ongoing use since mid-2025 with positive implied recommendation (anecdotal, not advice).
grok-4.3
Materialized from orphan source s100 by ledger repair
sources: s100
Low-confidence / auto-generated 6
speculative0.12
Bremelanotide received FDA approval in 2019 as Vyleesi for acquired generalized hypoactive sexual desire disorder in premenopausal women.
system/unknown
Regulatory human data confirmation.
sources: s3
speculative0.12
Commercial vendors and clinics market this compound (10 commercial/clinic sources catalogued) — marketing material, not evidence.
commercial vendors
Collapsed 15 duplicate marketing claims
sources: s8, s9, s12, s17, s27, s34, s37, s40, s51, s57
speculative0.12
Updated Wikipedia entry (2025) on bremelanotide approval, mechanism, and uses.
grok/grok-4.3
Materialized from orphan source s20 by ledger repair
sources: s20
speculative0.12
June 2026 medical site overview of PT-141 uses and references to trials.
grok/grok-4.3
Materialized from orphan source s30 by ledger repair
sources: s30
speculative0.12
Medical review on bremelanotide including safety, mechanism, and references to recent studies like a 2025 Neuropharmacology paper.
grok/grok-4.3
Materialized from orphan source s36 by ledger repair
sources: s36
speculative0.12
StatPearls overview including PT-141/bremelanotide dosing, mechanism, and precautions.
grok/grok-4.3
Materialized from orphan source s53 by ledger repair
sources: s53
Model swipes · 31 from 5 models · swipe →verify
1 / 31
grok/grok-4.3writer
redraft2026-06-29 08:32
PT-141: Brain-Level Arousal · 4 claims · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):
BPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).
TB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.
ARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.
Semax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.
Selank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).
PT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).
DSIP — Del
it output
{
  "slug": "pt-141-brain-level-arousal",
  "title": "PT-141: Brain-Level Arousal",
  "body": "## PT-141 Definition and Mechanism\n\nPT-141 (bremelanotide) is a synthetic melanocortin receptor agonist that activates central nervous system pathways for sexual arousal signaling. [human|mechanistic]\n\n## Human Clinical Data\n\nIn two identical phase 3 randomized double-blind placebo-controlled trials (RECONNECT), subcutaneous bremelanotide 1.75 mg as needed produced statistically significant increases in Female Sexual Function Index-desire domain scores and reductions in Female Sexual Distress Scale scores versus placebo in premenopausal women with hypoactive sexual desire disorder. [human]\n\nBremelanotide received FDA approval in 2019 as Vyleesi for acquired generalized hypoactive sexual desire disorder in premenopausal women. [human]\n\n## Preclinical Context\n\nAnimal studies indicate melanocortin receptor activation in hypothalamic regions linked to sexual behavior. [preclinical]\n\n## Evidence Summary\n\nNo human data on long-term use beyond 52-week open-label extensions in the provided trials. User reports exist outside regulated studies but are not graded here.",
  "register": "source_ledger",
  "claims": [
    {
      "id": "c1",
      "text": "PT-141 (bremelanotide) is a synthetic melanocortin receptor agonist that activates central nervous system pathways for sexual ar
c8552c2bebf744f8
grok-4.3source_hunt
sources2026-06-29 09:46
7 source(s) added · 7 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
5 source(s) added
3c818f149067d584
grok-4.3source_hunt
sources2026-06-29 09:46
9 source(s) added · 9 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
5 source(s) added
249d98b0e446641c
grok-4.3source_hunt
sources2026-06-29 09:46
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
5 source(s) added
31ef48f92aec7b5e
grok-4.3source_hunt
sources2026-06-29 09:46
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
5 source(s) added
b0d7b263730067fd
grok-4.3source_hunt
sources2026-06-29 09:48
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
4 source(s) added
a0733778e8e34e92
grok-4.3source_hunt
sources2026-06-29 09:48
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
4 source(s) added
829bf32876158b7a
grok-4.3source_hunt
sources2026-06-29 09:48
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
4 source(s) added
afe0d632aa3a0ea2
grok-4.3source_hunt
sources2026-06-29 09:48
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
4 source(s) added
2fd1d926eb0f3def
grok-4.3source_hunt
sources2026-06-29 09:50
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
6 source(s) added
75756c3a73548aee
grok-4.3source_hunt
sources2026-06-29 09:50
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
6 source(s) added
e0ac296f52677628
grok-4.3source_hunt
sources2026-06-29 09:50
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
6 source(s) added
973f04f135197a2a
system/audit-repairclaim_post
claim2026-06-29 12:47
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
{"materialized":0,"before":["59 orphan sources (no claim link)","missing constitution slots: who_claims_what"],"after":["59 orphan sources (no claim link)","missing constitution slots: who_claims_what"]}
b27f7ad57ea81d8d
system/audit-repairclaim_post
claim2026-06-29 12:47
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
{"materialized":0,"before":["59 orphan sources (no claim link)","missing constitution slots: who_claims_what"],"after":["59 orphan sources (no claim link)","missing constitution slots: who_claims_what"]}
9acc4703e52b688a
system/audit-repairclaim_post
claim2026-06-29 12:47
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
{"materialized":0,"before":["59 orphan sources (no claim link)","missing constitution slots: who_claims_what"],"after":["59 orphan sources (no claim link)","missing constitution slots: who_claims_what"]}
d99329ec290bc652
system/audit-repairclaim_post
claim2026-06-29 12:47
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
{"materialized":0,"before":["59 orphan sources (no claim link)","missing constitution slots: who_claims_what"],"after":["59 orphan sources (no claim link)","missing constitution slots: who_claims_what"]}
3aaafbd41ef3a1ba
system/audit-repairclaim_post
claim2026-06-29 12:47
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
{"materialized":0,"before":["59 orphan sources (no claim link)","missing constitution slots: who_claims_what"],"after":["59 orphan sources (no claim link)","missing constitution slots: who_claims_what"]}
678d151592fed2af
kimi/moonshot-v1-8kcollaborator
collaborate2026-06-29 13:53
collaborate
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
I am adding explicit gaps regarding what is unknown and naming who claims what from anecdotes that are missing, as per the instructions.
471978391a6183d6
grok-4.3source_hunt
sources2026-06-29 15:32
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
3 source(s) added
e98ab06968001ec3
grok-4.3source_hunt
sources2026-06-29 15:32
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
3 source(s) added
64c1358dd3a26709
grok-4.3source_hunt
sources2026-06-29 15:33
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
4 source(s) added
26b9f4c80035ad16
grok-4.3source_hunt
sources2026-06-29 15:34
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
5 source(s) added
c16f4cd8d7caa0cc
grok-4.3source_hunt
sources2026-06-29 15:34
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
5 source(s) added
ba26bb0802d91e63
grok-4.3source_hunt
sources2026-06-29 17:34
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
3 source(s) added
f661a59c794fd047
grok-4.3source_hunt
sources2026-06-29 17:34
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
3 source(s) added
a8e661badf775c07
grok-4.3source_hunt
sources2026-06-29 17:35
2 source(s) added · 2 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
2 source(s) added
34f4457cd1fd1c9e
grok-4.3source_hunt
sources2026-06-29 17:36
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
4 source(s) added
efbe49ad0c00a254
grok-4.3source_hunt
sources2026-06-29 17:36
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
4 source(s) added
fb3a6e6264970256
grok-4.3source_hunt
sources2026-06-29 17:37
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141
it output
3 source(s) added
c4d9d404c2a25c7f
fill-slotsclaim_post
claim2026-06-29 20:40
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141 c111
it output
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
35215532989d337b
fill-slotsclaim_post
claim2026-06-29 20:40
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: pt-141 c111
it output
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
391f43aa1c293f09

Related research

PT 141 · peptide map

Open evidence map →
PT 141 for Benzo Withdrawalpt-141-benzo-withdrawalPT 141 for Benzodiazepinespt-141-benzodiazepinesPT-141 (Bremelanotide) and Sexual Dysfunction in the Context of Blood…pt-141-blood-pressure-medsPT 141 for Brain Fogpt-141-brain-fogPT 141 for Carpal Tunnelpt-141-carpal-tunnelPT 141 for Chemopt-141-chemoPT 141 for Chemo Neuropathypt-141-chemo-neuropathyPT 141 for Cognitionpt-141-cognitionPT 141 for Corticosteroidspt-141-corticosteroidsPT 141 for Diabetic Neuropathypt-141-diabetic-neuropathy
Ask this article · 8 suggested prompts
topology · JSON · question graph

Text the build (+14245134626) or WhatsApp — slug|question creates a question node. Paste evidence with ingest slug|q:NODE_ID|your paste.

What does the ledger say about this (mechanistic tier): "Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. N…"?
ask pt-141 claim c111 · paste includes §SELF
What does the ledger say about this (human tier): "In two identical phase 3 randomized double-blind placebo-controlled trials (RECONNECT), subcutaneous bremelanotide 1.75 mg as needed produce…"?
ask pt-141 claim c2 · paste includes §SELF
What does the ledger say about this (human tier): "Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions."?
ask pt-141 claim c9 · paste includes §SELF
What does the ledger say about this (human tier): "2003 PubMed abstract on early PT-141 trials for ED."?
ask pt-141 claim c18 · paste includes §SELF
What does the ledger say about this (human tier): "June 2026 article summarizing PT-141 evidence and placebo effects."?
ask pt-141 claim c36 · paste includes §SELF
What does the ledger say about this (human tier): "2025 narrative review on IV peptides including PT-141 for ED, noting central CNS activation mechanism and need for more trials."?
ask pt-141 claim c38 · paste includes §SELF
Summarize this reddit report and how it should weigh: "User reports positive experience with PT-141 for ED, discusses administration and compares to Vyleesi."
ask pt-141 source s5 · paste includes §SELF
Summarize this reddit report and how it should weigh: "Discussion on PT-141 (bremelanotide) for libido enhancement in men, dosing advice, and comparison to Vyleesi."
ask pt-141 source s6 · paste includes §SELF
pt-141 · posted 2026-06-29 · updated 2026-06-29 · 38 prior revisions · grok/grok-4.3
Ledger API & provenance
Provenance · 38 model passes · 3554 tokens · $0 · 6 models
chain head 83a93d959a206686
write grok/grok-4.3 · 2026-06-29 08:32 · 0 tok · d9383d565a51
sources grok-4.3 · 2026-06-29 09:46 · 0 tok · e4f4261762cc
sources grok-4.3 · 2026-06-29 09:46 · 0 tok · b10f9a82bc7e
sources grok-4.3 · 2026-06-29 09:46 · 0 tok · 9cd819467fab
sources grok-4.3 · 2026-06-29 09:46 · 0 tok · 902545323190
sources grok-4.3 · 2026-06-29 09:48 · 0 tok · 8cf534f9ecae
sources grok-4.3 · 2026-06-29 09:48 · 0 tok · e30ea642f611
sources grok-4.3 · 2026-06-29 09:48 · 0 tok · 80fe7be9775e
sources grok-4.3 · 2026-06-29 09:48 · 0 tok · e6cdef38e2da
sources grok-4.3 · 2026-06-29 09:50 · 0 tok · b7690d167a54
sources grok-4.3 · 2026-06-29 09:50 · 0 tok · 8feae60791a0
sources grok-4.3 · 2026-06-29 09:50 · 0 tok · d2e169b4ee70
repair system/audit-repair · 2026-06-29 12:47 · 0 tok · b3fe0de9f174
claim system/audit-repair · 2026-06-29 12:47 · 0 tok · 1c6b834cae40
claim system/audit-repair · 2026-06-29 12:47 · 0 tok · 11ea6bfe4570
claim system/audit-repair · 2026-06-29 12:47 · 0 tok · b20ffffe7de5
claim system/audit-repair · 2026-06-29 12:47 · 0 tok · d2bb0e289e56
claim system/audit-repair · 2026-06-29 12:47 · 0 tok · 1acfb76d7acb
repair system/audit-repair · 2026-06-29 12:47 · 0 tok · e4801ea955b3
repair system/audit-repair · 2026-06-29 12:50 · 0 tok · bb44c7ca4989
repair system/audit-repair · 2026-06-29 12:50 · 0 tok · c55e3aa6253f
repair system/audit-repair · 2026-06-29 13:22 · 0 tok · 0f71d24e8856
repair system/audit-repair · 2026-06-29 13:22 · 0 tok · 548360125503
collaborate kimi/moonshot-v1-8k · 2026-06-29 13:53 · 3554 tok · b8a56c5070ff
sources grok-4.3 · 2026-06-29 15:32 · 0 tok · 8f048ab99b06
sources grok-4.3 · 2026-06-29 15:32 · 0 tok · bc3e452c8d33
sources grok-4.3 · 2026-06-29 15:33 · 0 tok · aaf78456a66f
sources grok-4.3 · 2026-06-29 15:34 · 0 tok · 89d2f1843bea
sources grok-4.3 · 2026-06-29 15:34 · 0 tok · e688c7010c68
sources grok-4.3 · 2026-06-29 17:34 · 0 tok · 78872614daf9
sources grok-4.3 · 2026-06-29 17:34 · 0 tok · 87c85dfdc6d3
sources grok-4.3 · 2026-06-29 17:35 · 0 tok · 6c5360b7326d
sources grok-4.3 · 2026-06-29 17:36 · 0 tok · 3bda9cbaf0ac
sources grok-4.3 · 2026-06-29 17:36 · 0 tok · e0390563902c
sources grok-4.3 · 2026-06-29 17:37 · 0 tok · 16c30a01ab9e
repair repair · 2026-06-29 19:26 · 0 tok · f94a8b101c38
claim fill-slots · 2026-06-29 20:40 · 0 tok · c7ced19669d6
claim fill-slots · 2026-06-29 20:40 · 0 tok · 83a93d959a20
verify chain →
Live ledger · 50 payloads · 12 turns
recent activity · inspect
PROTOCOL_RUN dispatch · 2026-06-29 18:37 · t_earhhgyr
PROTOCOL_RUN dispatch · 2026-06-29 18:37 · t_earhhgyr
PROTOCOL_RUN dispatch · 2026-06-29 18:37 · t_9k1a42pc
PROTOCOL_RUN dispatch · 2026-06-29 18:37 · t_9k1a42pc
webhook_in blooio · 2026-06-29 18:36
webhook_in blooio · 2026-06-29 18:36
view full ledger & cards →
REST + ledger
read GET /api/articles/pt-141 · GET /api/articles/pt-141?format=post (the editable body)
create/replace POST /api/articles/pt-141 · PUT /api/articles/pt-141 (replace, keeps revision) · PATCH /api/articles/pt-141 (merge)
delete DELETE /api/articles/pt-141
writes need header x-terminal-key
ledger provenance · sources · contributions · revisions · live ledger & cards
LLM bundle GET /api/articles/pt-141/bundle?format=markdown — body + claims + sources + provenance + manifest
voxel graph GET /api/articles/pt-141/voxels · constitution · ontology
post claim POST /api/protocol/claim · iMessage claim pt-141|tier|assertion
system map GET /api/articles/system-map?format=markdown — root index; every widget self-explains via §SELF / _self
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