Evidence review

Selank: Non-Sedating Anxiolytic

#peptide#selank
bundle · json · system map · manifest

Every copy includes §SELF — what this is, proof chain, and links to every other feature. No context required.

§SELF — this page explains the system
## §SELF — miscsubjects (paste without context)

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `human_page` — **Human article page**
Rendered article with claims, sources, copy widgets, ask prompts.
- **article slug:** `selank`
- **contains:** rendered article, copy widgets, claims, sources, ask prompts
- **how to use:** Use Copy for LLM or Copy system map — both paste without context.
- **read:** https://miscsubjects.com/a/selank

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/selank/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **bundle** — Paste-ready package: body + claims + sources + voxels + provenance + manifest + constitution. · https://miscsubjects.com/api/articles/selank/bundle?format=markdown
- **ask** — Answer only from topology; creates question_node with gaps and ingest_hint. · https://miscsubjects.com/api/articles/selank/prompts
- **topology** — Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER. · https://miscsubjects.com/api/articles/selank/topology

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

*Not medical advice. Tier-honest. Cite claim/source ids.*

Regeneration vs degeneration — where this fits

The body is always doing two things at once: breaking down (degeneration) and building back (regeneration). A condition persists when breakdown outruns repair. Most drugs used for symptoms suppress a signal (pain, acid, anxiety, inflammation) without fixing the tissue that caused the signal. Peptides in this ledger are studied for repair pathways: new blood vessels, repair-cell migration, nerve regrowth, gut lining, neural connections. This article maps one compound through that frame — what it is, how it is proposed to work, what evidence exists, and what people report.

This topic: Selank is studied for anxiety-related pathways without classic benzodiazepine sedation. In the regeneration frame: anxiety can follow tissue stress (gut, sleep, stimulant load); Selank research asks whether stabilizing neurochemistry supports recovery rather than only muting feeling.

What it is

Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only. 2026 review mentioning Selank as a neuroactive peptide with potential effects on BDNF and neuroplasticity in orthopaedic context.

How it works

Step logic:

  1. Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
  2. 2026 review mentioning Selank as a neuroactive peptide with potential effects on BDNF and neuroplasticity in orthopaedic context.
  3. Compares intranasal vs intraperitoneal Selank in mice strains, showing strain-specific anxiolytic/nootropic effects via GABA/NMDA receptor changes.
  4. Selank alters GABA-related gene expression in rat frontal cortex, supporting allosteric GABA modulation mechanism.
  5. 2020 study using fMRI showing Selank and Semax effects on amygdala-temporal cortex connectivity.
  6. 2019 rat study on Selank protecting against alcohol-related memory issues via BDNF regulation.
  7. 2021 study on Selank's stress-protective effects on cytokines in socially stressed animals.

Why it would work (logic chain)

  1. IF Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  2. IF 2026 review mentioning Selank as a neuroactive peptide with potential effects on BDNF and neuroplasticity in orthopaedic context. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  3. IF Compares intranasal vs intraperitoneal Selank in mice strains, showing strain-specific anxiolytic/nootropic effects via GABA/NMDA receptor changes. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  4. IF Selank alters GABA-related gene expression in rat frontal cortex, supporting allosteric GABA modulation mechanism. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  5. IF 2020 study using fMRI showing Selank and Semax effects on amygdala-temporal cortex connectivity. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  6. IF 2019 rat study on Selank protecting against alcohol-related memory issues via BDNF regulation. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).

Why people take it

Reasons that appear in this ledger:

  1. X post detailing Selank's potential broader effects on immune system, inflammation, gut health, and personal dosing protocol.
  2. Positive: amazing feel, no side effects on daily 1mg each SubQ.
  3. Positive: helped insomnia and body pains from pregabalin withdrawal.
  4. Mixed: initial amazing focus/calm but rapid tolerance buildup; recommend as-needed not daily.
  5. Bad outcome (paranoia, anxiety) for one user; positive for their brother.
  6. Positive effects on calm, creativity, anxiety reduction without sedation.
  7. Positive anecdotal report on Selank improving deep sleep significantly (8/10 rating).
  8. Mixed: positive for son's anxiety and sociality, no effect for the poster.
  9. X post promoting Semax+Selank for traders' focus and calm; anecdotal stacking mention.
  10. X reply sharing personal Selank dosing anecdote (anecdotal, not advice) and interest in outcomes.

How many people take it

There is no reliable global count of how many people take this compound. That number is not in this ledger.

What we can count from this ledger:

  • 60 anecdote source(s) (posts, threads, comments)
  • 60 anecdote-tier claim(s) derived from them

Logic: 60 online report(s) are catalogued here. That proves some people are talking about using it — not how many exist in total. Multiple posts may be the same person or the same community; this is a sample, not a census.

Evidence inventory

This is a count of what is in this ledger — not a claim about all research worldwide.

  • Scientific sources catalogued (PubMed, trials, reviews): 31
  • Claims tagged human evidence: 13
  • Claims tagged preclinical (animal/lab): 8
  • Claims tagged anecdotal: 60
  • Reddit posts catalogued: 40
  • X posts catalogued: 14
  • Other anecdote sources (YouTube, Instagram, etc.): 6
  • Total sources in chain: 92

Quantified confidence (this ledger): 0.95 / 1.00 — moderate — human claims present in ledger

Formula: human claims×0.12 + preclinical×0.04 + anecdote×0.015 + studies (capped). This is not clinical certainty — it measures how much graded evidence is catalogued here.

What scientists say

Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia (source s1)

Russian RCT comparing Selank to medazepam in anxiety patients; comparable efficacy with better tolerability profile.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Selank Administration Affects the Expression of Some Genes Involved in Neurotransmission (source s2)

Rat frontal cortex gene-expression study post-Selank or GABA administration showing overlapping but distinct patterns consistent with allosteric GABA modulation.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats (source s3)

2017 study showing Selank's anxiolytic effects comparable to benzodiazepines in rat stress model.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats (source s4)

2019 rat study on Selank protecting against alcohol-related memory issues via BDNF regulation.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress (source s5)

2021 study on Selank's stress-protective effects on cytokines in socially stressed animals.

Evidence type: Published research.

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions (source s8)

2026 review mentioning Selank as a neuroactive peptide with potential effects on BDNF and neuroplasticity in orthopaedic context.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity (source s22)

2018 review on molecular mechanisms of Selank as positive allosteric modulator of GABA receptors for anxiolytic effects.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Functional Connectomic Approach to Studying Selank and Semax Effects (source s23)

2020 study using fMRI showing Selank and Semax effects on amygdala-temporal cortex connectivity.

Evidence type: Published research.

Selank Peptide | Benefits, Safety & Buying Advice [2026] (source s24)

2026 comprehensive review covering mechanisms, studies, dosing, safety (notes FDA concerns on compounded versions), and user experience.

Evidence type: Published research.

A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders (source s27)

2014 Russian study comparing Selank to phenazepam in 60 patients with anxiety disorders; Selank showed comparable anxiolytic effects with better tolerability and lasting effects.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Semax and Selank: The Cognitive Peptides Now Legal for Compounding — What the Evidence Says (source s28)

2026 review of Selank evidence, Russian Phase III trials for GAD, mechanisms including GABA modulation and enkephalinase inhibition, and 2026 US compounding regulatory updates.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Selank for Anxiety: Evidence, Mechanism, Realistic Expectations (source s29)

2026 psychiatrist review summarizing Russian clinical data on Selank for GAD, mechanisms, and realistic expectations vs benzos.

Evidence type: Published research.

N-Acetyl Selank Amidate | Reviews, Clinical Studies, and Research (source s32)

Overview of Selank clinical studies, including GAD trials and mechanisms for anxiolytic and nootropic effects.

Evidence type: Published research.

Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats (source s33)

2022 rat study shows Selank reduces morphine withdrawal symptoms comparably to diazepam.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism (source s40)

Study on Semax and Selank effects in rat model of Parkinsonism-like symptoms, showing Selank reduced anxiety levels.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation (source s41)

Selank effective in reducing alcohol withdrawal anxiety symptoms in rats without affecting ethanol consumption.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

What Is Selank? Benefits, Uses & Anxiety Support (source s44)

Overview of Selank for anxiety, cognitive enhancement, with references to studies on GABA modulation.

Evidence type: Published research.

Semax and Selank Together: Side Effects & SSRI Safety (source s45)

Discussion of Selank mechanisms, evidence from Russian trials, and use with other treatments.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

What people say on Reddit

Selank. Life changing so far. — Reddit, r/Nootropics (source s6)

User anecdote reporting significant anxiety reduction with Selank injections for GAD/panic disorder.

Experiences with Selank : r/Anxiety — Reddit, r/Anxiety (source s9)

User anecdotes on Selank reducing anxiety without sedation, improving social comfort and public speaking.

Selank day 3 - anyone else get this? (anxious ADHD type) — Reddit, r/Nootropics (source s10)

Reddit user reports subtle calming effect on anxiety and ADHD symptoms after 3 days of Selank, feeling present and focused.

Does Selank actually reduce anxiety or just make you tired? — Reddit, r/Biohackers (source s12)

Positive: reduced stress measured by device; mixed: sometimes tired/nothing; negative: restless/anxious after 2 months, headache, hard to rest.

Has anyone tried Semax and Selank Stack? — Reddit, r/Biohackers (source s13)

Mixed: better sleep on it but REM drop off it; positive stack reports for focus/calm.

Thoughts on Semax/Selank/Noopept etc. while on Vyvanse? — Reddit, r/Biohackers (source s14)

Positive: reduces anxiety/jitteriness, aids focus/study, counters paranoia from substances.

Selank + Semax – Observed Effects (Focus, Anxiety, Sleep, Hairloss, etc) — Reddit, r/Nootropics (source s15)

Positive: increased focus, reduced baseline anxiety, emotional stabilization; note on possible hair loss side effect.

Please help me. Selank is amazing for me but I can not tolerate it — Reddit, r/NooTopics (source s16)

Strong positive for social anxiety/ND issues, eye contact, reduced BP spike; user seeks tolerance help.

Paradoxical insomnia/anxiety reaction to Selank? — Reddit, r/Nootropics (source s17)

Negative paradoxical reaction: worsened insomnia and anxiety at ~400mcg/day intranasal.

SUCCESS: I think Selank just cured my depression and addiction — Reddit, r/depressionregimens (source s18)

Dramatic positive: rapid mood lift, reduced numbness/depression/addiction feelings after first dose.

Have peptides been a game changer for you? What ... — Reddit, r/Biohackers (source s26)

2025+ user anecdote reporting Selank + DSIP dramatically improved anxiety and sleep.

Help with anxiety? Already on SSRI — Reddit, r/Nootropics (source s30)

2025-2026 Reddit anecdotes on Selank use alongside SSRIs for anxiety relief with minimal side effects.

Selank Experience : r/Biohackers — Reddit, r/Biohackers (source s34)

User reports positive experience with Selank nasal spray for anxiety and depression, better than SSRIs.

im really interested in trying selank for my crippling anxiety ... — Reddit, r/Nootropics (source s35)

User seeking advice on Selank for severe anxiety.

Semax and Selank experience : r/StackAdvice — Reddit, r/StackAdvice (source s36)

User shares experience with subcutaneous Selank and Semax stack.

Selank & Semax: Powerful Peptides and Noteworthy ... — Reddit, r/Biohackers (source s37)

Discussion on Selank/Semax benefits for brain healing and withdrawal.

What people say on X

Selank peptide effects and dosing — X (source s11)

X post detailing Selank's potential broader effects on immune system, inflammation, gut health, and personal dosing protocol.

X post on Subq Selank/Semax — X (source s19)

Positive: amazing feel, no side effects on daily 1mg each SubQ.

X post on Selank for withdrawal — X (source s20)

Positive: helped insomnia and body pains from pregabalin withdrawal.

X post on injectable Semax/Selank tolerance — X (source s21)

Mixed: initial amazing focus/calm but rapid tolerance buildup; recommend as-needed not daily.

PTSD experience with Selank — X (source s60)

Bad outcome (paranoia, anxiety) for one user; positive for their brother.

Selank stack experience — X (source s61)

Positive effects on calm, creativity, anxiety reduction without sedation.

Selank/Semax user experience — X (source s74)

Positive anecdotal report on Selank improving deep sleep significantly (8/10 rating).

X reply on Selank effects varying by person — X (source s78)

Mixed: positive for son's anxiety and sociality, no effect for the poster.

Peptides for Traders post — X (source s81)

X post promoting Semax+Selank for traders' focus and calm; anecdotal stacking mention.

Selank run reply — X (source s82)

X reply sharing personal Selank dosing anecdote (anecdotal, not advice) and interest in outcomes.

Selank nasal spray post — X (source s83)

X post recommending Selank nasal for bedtime use with implied positive sleep/anxiety outcome (anecdotal).

Conversation on Selank injection vs nasal — X (source s88)

User anecdote comparing administration methods for Selank.

Peptide dosing — X (source s89)

Daily 1mg each Semax/Selank stacking anecdote.

Today's nootropic stack — X (source s90)

Mentions intranasal Selank in stack (anecdotal).

Other anecdote evidence

Selank Deep Dive: Anxiety, Cognition, Immune System — YouTube (source s7)

Video reviewing Selank science and user reports on anxiety relief during benzo withdrawal.

Selank: Revolutionizing Mental Health and Cognitive Enhancement – A Doctor’s Guide — YouTube (source s25)

2025 doctor-led video on mechanisms, clinical applications (anxiety, PTSD, cognition, immune), dosing protocols, case studies.

Selank | One of the Best Nootropics for Anxiety Relief & Mental Clarity — YouTube (source s31)

2025 YouTube video discussing Selank as a nootropic for anxiety and cognitive benefits.

Selank experience? — online (source s68)

User reports quick onset calm, focus, well-being from nasal Selank lasting ~3 hours; good overall experience but discontinued due to administration concerns.

Selank experience? — online (source s69)

Positive report on reduced presentation/speech anxiety, lowered heart rate, clear mind during high-stress work scenarios with Selank.

Selank nasal spray experience — online (source s70)

User shares positive experience with Selank nasal spray for anxiety reduction, feeling more chill and clear-headed.

What we do not know

  1. There is a lack of long-term safety and efficacy data on Selank for the treatment of anxiety disorders.

Safety and limits

  1. Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.

---

Not medical advice. Counts and quotes are from this article's hash-chained ledger. Anecdote = real reports, not proof. Animal studies ≠ human proof.

Selank · peptide map

Evidence map

Hover a node — its path lights up. Click to open the article.

Full map →
JumpSelank for Adderall-Induced Jitteriness and Anxiety · 8 humanSemax, DSIP, and Selank: Evidence Review on Mechanisms Related to Cogn… · 6 humanPT-141 + Selank for SSRI Users: Evidence Review · 3 humanAdderall Amphetamine
Evidence · 92 sources · swipe →chain b99cfa3a6fbb · verify chain · provenance
1 / 92
Evidence ledger 93 · tier-ranked · API
mechanistic
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
human
2026 review mentioning Selank as a neuroactive peptide with potential effects on BDNF and neuroplasticity in orthopaedic context.
sources: s8
human
2018 review on molecular mechanisms of Selank as positive allosteric modulator of GABA receptors for anxiolytic effects.
sources: s22
human
2026 review of Selank evidence, Russian Phase III trials for GAD, mechanisms including GABA modulation and enkephalinase inhibition, and 2026 US compounding regulatory updates.
sources: s28
human
2015 Russian RCT (n=70) found Selank + phenazepam faster anxiolytic effect and fewer side effects than phenazepam alone in anxiety disorders.
sources: s46
80 more ranked claims
human0.80
2008 study showed Selank modulates IL-6 and Th1/Th2 balance in anxiety-asthenic patients, suggesting immunomodulatory role.
grok/grok-4.3
Materialized from orphan source s47 by ledger repair
sources: s47
human0.80
2026 comparison noting Russian Phase III for GAD, safety in short-term studies, immunomodulatory effects.
grok/grok-4.3
Materialized from orphan source s54 by ledger repair
sources: s54
human0.80
Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
system/protocol
Required constitution slot: disclaimer
preclinical0.50
Selank administration in rats alters expression of 45 neurotransmission-related genes at 1 hour and 22 genes at 3 hours, with positive correlation to GABA effects.
system/repair
Direct evidence from controlled animal gene-expression experiments.
sources: s2
preclinical0.50
Study on Semax and Selank effects in rat model of Parkinsonism-like symptoms, showing Selank reduced anxiety levels.
grok/grok-4.3
Materialized from orphan source s40 by ledger repair
sources: s40
preclinical0.50
Selank effective in reducing alcohol withdrawal anxiety symptoms in rats without affecting ethanol consumption.
grok/grok-4.3
Materialized from orphan source s41 by ledger repair
sources: s41
preclinical0.50
Compares intranasal vs intraperitoneal Selank in mice strains, showing strain-specific anxiolytic/nootropic effects via GABA/NMDA receptor changes.
grok/grok-4.3
Materialized from orphan source s50 by ledger repair
sources: s50
preclinical0.50
Selank alters GABA-related gene expression in rat frontal cortex, supporting allosteric GABA modulation mechanism.
grok/grok-4.3
Materialized from orphan source s51 by ledger repair
sources: s51
system0.35
Selank: Non-Sedating Anxiolytic is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.
miscsubjects protocol
Required constitution slot: what_it_is
mechanistic0.30
2020 study using fMRI showing Selank and Semax effects on amygdala-temporal cortex connectivity.
grok/grok-4.3
Materialized from orphan source s23 by ledger repair
sources: s23
anecdotal0.30
X post detailing Selank's potential broader effects on immune system, inflammation, gut health, and personal dosing protocol.
grok/grok-4.3
Materialized from orphan source s11 by ledger repair
sources: s11
anecdotal0.30
Positive: amazing feel, no side effects on daily 1mg each SubQ.
grok/grok-4.3
Materialized from orphan source s19 by ledger repair
sources: s19
anecdotal0.30
Positive: helped insomnia and body pains from pregabalin withdrawal.
grok/grok-4.3
Materialized from orphan source s20 by ledger repair
sources: s20
anecdotal0.30
Mixed: initial amazing focus/calm but rapid tolerance buildup; recommend as-needed not daily.
grok/grok-4.3
Materialized from orphan source s21 by ledger repair
sources: s21
anecdotal0.30
Bad outcome (paranoia, anxiety) for one user; positive for their brother.
grok/grok-4.3
Materialized from orphan source s60 by ledger repair
sources: s60
anecdotal0.30
Positive effects on calm, creativity, anxiety reduction without sedation.
grok/grok-4.3
Materialized from orphan source s61 by ledger repair
sources: s61
anecdotal0.30
Positive anecdotal report on Selank improving deep sleep significantly (8/10 rating).
grok-4.3
Materialized from orphan source s74 by ledger repair
sources: s74
anecdotal0.30
Mixed: positive for son's anxiety and sociality, no effect for the poster.
grok-4.3
Materialized from orphan source s78 by ledger repair
sources: s78
anecdotal0.30
X post promoting Semax+Selank for traders' focus and calm; anecdotal stacking mention.
grok-4.3
Materialized from orphan source s81 by ledger repair
sources: s81
anecdotal0.30
X reply sharing personal Selank dosing anecdote (anecdotal, not advice) and interest in outcomes.
grok-4.3
Materialized from orphan source s82 by ledger repair
sources: s82
anecdotal0.30
User anecdote comparing administration methods for Selank.
grok-4.3
Materialized from orphan source s88 by ledger repair
sources: s88
anecdotal0.30
Daily 1mg each Semax/Selank stacking anecdote.
grok-4.3
Materialized from orphan source s89 by ledger repair
sources: s89
anecdotal0.30
Mentions intranasal Selank in stack (anecdotal).
grok-4.3
Materialized from orphan source s90 by ledger repair
sources: s90
human0.22low confidence
In a 2008 randomized study of 62 patients with GAD and neurasthenia, Selank showed anxiolytic efficacy comparable to medazepam on psychometric scales without reported sedation, cognitive impairment, tolerance or withdrawal.
system/repair
Primary human trial evidence separating Selank from benzodiazepine side-effect profile.
sources: s1
human0.22low confidence
2014 Russian study comparing Selank to phenazepam in 60 patients with anxiety disorders; Selank showed comparable anxiolytic effects with better tolerability and lasting effects.
grok/grok-4.3
Materialized from orphan source s27 by ledger repair
sources: s27
human0.22
Discussion of Selank mechanisms, evidence from Russian trials, and use with other treatments.
grok/grok-4.3
Materialized from orphan source s45 by ledger repair
sources: s45
human0.22low confidence
2026 review of Selank as GABA-A positive allosteric modulator, approved in Russia for GAD, limited Western validation.
grok/grok-4.3
Materialized from orphan source s52 by ledger repair
sources: s52
human0.22
2026 evidence scoring: 8/25 human trial score, approved in Russia, mostly Russian studies and animal data.
grok/grok-4.3
Materialized from orphan source s53 by ledger repair
sources: s53
human0.22low confidence
There is a lack of long-term safety and efficacy data on Selank for the treatment of anxiety disorders.
kimi-collaborator
This claim addresses a gap in the ledger regarding the absence of long-term studies on Selank, which is an important consideration for understanding its full potential as a treatment option.
sources: s1
preclinical0.22low confidence
2017 study showing Selank's anxiolytic effects comparable to benzodiazepines in rat stress model.
grok/grok-4.3
Materialized from orphan source s3 by ledger repair
sources: s3
preclinical0.22low confidence
2019 rat study on Selank protecting against alcohol-related memory issues via BDNF regulation.
grok/grok-4.3
Materialized from orphan source s4 by ledger repair
sources: s4
preclinical0.22low confidence
2022 rat study shows Selank reduces morphine withdrawal symptoms comparably to diazepam.
grok/grok-4.3
Materialized from orphan source s33 by ledger repair
sources: s33
mechanistic0.22low confidence
2021 study on Selank's stress-protective effects on cytokines in socially stressed animals.
grok/grok-4.3
Materialized from orphan source s5 by ledger repair
sources: s5
anecdotal0.22low confidence
User anecdote reporting significant anxiety reduction with Selank injections for GAD/panic disorder.
grok/grok-4.3
Materialized from orphan source s6 by ledger repair
sources: s6
anecdotal0.22low confidence
Video reviewing Selank science and user reports on anxiety relief during benzo withdrawal.
grok/grok-4.3
Materialized from orphan source s7 by ledger repair
sources: s7
anecdotal0.22low confidence
User anecdotes on Selank reducing anxiety without sedation, improving social comfort and public speaking.
grok/grok-4.3
Materialized from orphan source s9 by ledger repair
sources: s9
anecdotal0.22low confidence
Reddit user reports subtle calming effect on anxiety and ADHD symptoms after 3 days of Selank, feeling present and focused.
grok/grok-4.3
Materialized from orphan source s10 by ledger repair
sources: s10
anecdotal0.22low confidence
Positive: reduced stress measured by device; mixed: sometimes tired/nothing; negative: restless/anxious after 2 months, headache, hard to rest.
grok/grok-4.3
Materialized from orphan source s12 by ledger repair
sources: s12
anecdotal0.22low confidence
Mixed: better sleep on it but REM drop off it; positive stack reports for focus/calm.
grok/grok-4.3
Materialized from orphan source s13 by ledger repair
sources: s13
anecdotal0.22low confidence
Positive: reduces anxiety/jitteriness, aids focus/study, counters paranoia from substances.
grok/grok-4.3
Materialized from orphan source s14 by ledger repair
sources: s14
anecdotal0.22low confidence
Positive: increased focus, reduced baseline anxiety, emotional stabilization; note on possible hair loss side effect.
grok/grok-4.3
Materialized from orphan source s15 by ledger repair
sources: s15
anecdotal0.22low confidence
Strong positive for social anxiety/ND issues, eye contact, reduced BP spike; user seeks tolerance help.
grok/grok-4.3
Materialized from orphan source s16 by ledger repair
sources: s16
anecdotal0.22low confidence
Negative paradoxical reaction: worsened insomnia and anxiety at ~400mcg/day intranasal.
grok/grok-4.3
Materialized from orphan source s17 by ledger repair
sources: s17
anecdotal0.22low confidence
Dramatic positive: rapid mood lift, reduced numbness/depression/addiction feelings after first dose.
grok/grok-4.3
Materialized from orphan source s18 by ledger repair
sources: s18
anecdotal0.22low confidence
2025+ user anecdote reporting Selank + DSIP dramatically improved anxiety and sleep.
grok/grok-4.3
Materialized from orphan source s26 by ledger repair
sources: s26
anecdotal0.22low confidence
2025-2026 Reddit anecdotes on Selank use alongside SSRIs for anxiety relief with minimal side effects.
grok/grok-4.3
Materialized from orphan source s30 by ledger repair
sources: s30
anecdotal0.22low confidence
2025 YouTube video discussing Selank as a nootropic for anxiety and cognitive benefits.
grok/grok-4.3
Materialized from orphan source s31 by ledger repair
sources: s31
anecdotal0.22low confidence
User reports positive experience with Selank nasal spray for anxiety and depression, better than SSRIs.
grok/grok-4.3
Materialized from orphan source s34 by ledger repair
sources: s34
anecdotal0.22low confidence
User seeking advice on Selank for severe anxiety.
grok/grok-4.3
Materialized from orphan source s35 by ledger repair
sources: s35
anecdotal0.22low confidence
User shares experience with subcutaneous Selank and Semax stack.
grok/grok-4.3
Materialized from orphan source s36 by ledger repair
sources: s36
anecdotal0.22low confidence
Discussion on Selank/Semax benefits for brain healing and withdrawal.
grok/grok-4.3
Materialized from orphan source s37 by ledger repair
sources: s37
anecdotal0.22low confidence
User described negative outcome with Selank leading to worsening depression and withdrawal after initial use.
grok/grok-4.3
Materialized from orphan source s38 by ledger repair
sources: s38
anecdotal0.22low confidence
Positive user report on Selank (with Semax) for reducing anxiety and brain fog in CPTSD context.
grok/grok-4.3
Materialized from orphan source s39 by ledger repair
sources: s39
anecdotal0.22low confidence
Anecdotal guide and user discussion on Selank benefits for anxiety without side effects of benzos.
grok/grok-4.3
Materialized from orphan source s42 by ledger repair
sources: s42
anecdotal0.22low confidence
User seeking experiences with Selank for panic/anxiety during internship.
grok/grok-4.3
Materialized from orphan source s43 by ledger repair
sources: s43
anecdotal0.22low confidence
Positive user report of reduced social anxiety and mental clutter from nasal Selank.
grok/grok-4.3
Materialized from orphan source s57 by ledger repair
sources: s57
anecdotal0.22low confidence
Mixed initial experience with Selank feeling stimulating like a mild stimulant.
grok/grok-4.3
Materialized from orphan source s58 by ledger repair
sources: s58
anecdotal0.22low confidence
Positive report on anxiety and IBS symptom reduction after 5 days.
grok/grok-4.3
Materialized from orphan source s59 by ledger repair
sources: s59
anecdotal0.22low confidence
2025/2026 Reddit post explaining Selank mechanisms, Russian origins, and user-oriented dosing/mechanisms overview.
grok/grok-4.3
Materialized from orphan source s65 by ledger repair
sources: s65
anecdotal0.22low confidence
Recent Reddit anecdote comparing subjective effects of Selank (calming, better sleep) vs Semax.
grok/grok-4.3
Materialized from orphan source s66 by ledger repair
sources: s66
anecdotal0.22low confidence
Anecdotal Reddit report of positive long-term effects on anxiety, memory, focus, and mood from Selank.
grok/grok-4.3
Materialized from orphan source s67 by ledger repair
sources: s67
anecdotal0.22low confidence
Anecdotal reports suggest Selank may have varying effects on individuals, with some users reporting reduced anxiety and others experiencing no noticeable effects.
kimi-collaborator
This claim fills a gap by summarizing anecdotal evidence from various sources, providing a more comprehensive view of user experiences with Selank.
sources: s6, s9, s10
anecdotal0.22low confidence
User reports quick onset calm, focus, well-being from nasal Selank lasting ~3 hours; good overall experience but discontinued due to administration concerns.
grok-4.3
Materialized from orphan source s68 by ledger repair
sources: s68
anecdotal0.22low confidence
Positive report on reduced presentation/speech anxiety, lowered heart rate, clear mind during high-stress work scenarios with Selank.
grok-4.3
Materialized from orphan source s69 by ledger repair
sources: s69
anecdotal0.22low confidence
User shares positive experience with Selank nasal spray for anxiety reduction, feeling more chill and clear-headed.
grok-4.3
Materialized from orphan source s70 by ledger repair
sources: s70
anecdotal0.22low confidence
User reports no noticeable effects on focus or memory from nasal Selank/Semax after multiple uses, suspects placebo or ineffective product; tried both preconstituted and lyophilized versions with same result.
grok-4.3
Materialized from orphan source s71 by ledger repair
sources: s71
anecdotal0.22low confidence
Positive: smoother social interactions, calm happy relaxed feeling. Negative: short duration, slight tolerance buildup after a week.
grok-4.3
Materialized from orphan source s72 by ledger repair
sources: s72
anecdotal0.22low confidence
User reports negative effects from Selank (200mcg): sedation, cognitive impairment, depressive symptoms; side effects persisted to next day, led to discontinuation.
grok-4.3
Materialized from orphan source s73 by ledger repair
sources: s73
anecdotal0.22low confidence
Positive user report on Selank/Semax stack reducing anxiety and ADHD symptoms without sedation or high, recommends cycling.
grok-4.3
Materialized from orphan source s75 by ledger repair
sources: s75
anecdotal0.22low confidence
Positive anecdotal on verbal fluency, clarity, and feeling 'on' after COVID-related brain fog.
grok-4.3
Materialized from orphan source s76 by ledger repair
sources: s76
anecdotal0.22low confidence
Positive user report on Semax/Selank stack dramatically improving ADHD symptoms like focus, brain fog, and emotional regulation via intranasal use after SubQ was less effective.
grok-4.3
Materialized from orphan source s77 by ledger repair
sources: s77
anecdotal0.22low confidence
Discussion on Adalank (N-Acetyl Selank Amidate variant) as improved Selank for anxiety/cognition; includes dosing anecdotes (anecdotal, not advice), comparisons, and user comments on effects like stress reduction and rarity.
grok-4.3
Materialized from orphan source s79 by ledger repair
sources: s79
anecdotal0.22low confidence
Users share experiences with Selank/Semax routes (nasal vs SubQ), effects on ADHD/brain fog/anxiety, dosing protocols (anecdotal, not advice), and mixed outcomes including limited noticeable benefits or side feelings.
grok-4.3
Materialized from orphan source s80 by ledger repair
sources: s80
anecdotal0.22low confidence
X post recommending Selank nasal for bedtime use with implied positive sleep/anxiety outcome (anecdotal).
grok-4.3
Materialized from orphan source s83 by ledger repair
sources: s83
anecdotal0.22low confidence
Discusses stacking Semax and Selank for focus without anxiety; anecdotal benefits for mental clarity.
grok-4.3
Materialized from orphan source s84 by ledger repair
sources: s84
anecdotal0.22low confidence
Explains Selank mechanisms, anxiolytic and nootropic effects; anecdotal user context implied.
grok-4.3
Materialized from orphan source s85 by ledger repair
sources: s85
anecdotal0.22low confidence
Anecdotal stacking advice and product info on Selank/Semax for anxiety and focus.
grok-4.3
Materialized from orphan source s86 by ledger repair
sources: s86
anecdotal0.22low confidence
Dosing anecdote (250-300mcg) and sleep/anxiety benefits; labeled anecdotal.
grok-4.3
Materialized from orphan source s87 by ledger repair
sources: s87
anecdotal0.22low confidence
User praises combo for anxiety and focus (anecdotal, not advice).
grok-4.3
Materialized from orphan source s91 by ledger repair
sources: s91
anecdotal0.22low confidence
Guide on combined nasal Selank/Semax stack for nootropic effects (anecdotal dosing context).
grok-4.3
Materialized from orphan source s92 by ledger repair
sources: s92
Low-confidence / auto-generated 8
speculative0.12
Commercial vendors and clinics market this compound (7 commercial/clinic sources catalogued) — marketing material, not evidence.
commercial vendors
Collapsed 10 duplicate marketing claims
sources: s1, s2, s25, s29, s32, s49, s56
speculative0.12
2026 comprehensive review covering mechanisms, studies, dosing, safety (notes FDA concerns on compounded versions), and user experience.
grok/grok-4.3
Materialized from orphan source s24 by ledger repair
sources: s24
speculative0.12
Overview of Selank for anxiety, cognitive enhancement, with references to studies on GABA modulation.
grok/grok-4.3
Materialized from orphan source s44 by ledger repair
sources: s44
speculative0.12
2016 rat study found Selank alters expression of 45 neurotransmission genes (esp. GABA-related) similarly to GABA, supporting GABAergic mechanism.
grok/grok-4.3
Materialized from orphan source s48 by ledger repair
sources: s48
speculative0.12
2026 overview of benefits from studies: anxiolytic without benzo sides, nootropic, immune support via IL-6/T-cells.
grok/grok-4.3
Materialized from orphan source s55 by ledger repair
sources: s55
speculative0.12
2026 article concluding insufficient evidence and no FDA approval for off-label Selank use in anxiety; discusses lack of Western validation.
grok/grok-4.3
Materialized from orphan source s62 by ledger repair
sources: s62
speculative0.12
March 2026 dosing guide detailing typical doses (100-900 mcg), protocols (10-30 days cycles), intranasal administration, safety notes, and comparison to Semax.
grok/grok-4.3
Materialized from orphan source s63 by ledger repair
sources: s63
speculative0.12
2026 comparison highlighting Selank's stronger anxiolytic evidence vs Semax for neuroprotection.
grok/grok-4.3
Materialized from orphan source s64 by ledger repair
sources: s64
Model swipes · 31 from 5 models · swipe →verify
1 / 31
grok/grok-4.3writer
redraft2026-06-29 08:32
Selank: Non-Sedating Anxiolytic · 3 claims · 2 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):
BPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).
TB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.
ARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.
Semax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.
Selank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).
PT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).
DSIP — Del
it output
{
  "slug": "selank-non-sedating-anxiolytic",
  "title": "Selank: Non-Sedating Anxiolytic",
  "body": "## Overview\nSelank is a synthetic heptapeptide derived from tuftsin with reported anxiolytic properties.\n\n## Human Data\nA 2008 randomized study compared intranasal Selank to medazepam in 62 patients with generalized anxiety disorder and neurasthenia.\n\n## Preclinical Data\nRat studies show alterations in gene expression related to neurotransmission.\n\n## Mechanism\nProposed allosteric effects on GABA_A receptors without direct agonism.",
  "register": "source_ledger",
  "claims": [
    {
      "id": "c1",
      "text": "In a 2008 randomized study of 62 patients with GAD and neurasthenia, Selank showed anxiolytic efficacy comparable to medazepam on psychometric scales without reported sedation, cognitive impairment, tolerance or withdrawal.",
      "section": "Human Data",
      "tier": "human",
      "source_ids": ["s1"],
      "source_status": "sourced",
      "why_material": "Primary human trial evidence separating Selank from benzodiazepine side-effect profile."
    },
    {
      "id": "c2",
      "text": "Selank administration in rats alters expression of 45 neurotransmission-related genes at 1 hour and 22 genes at 3 hours, with positive correlation to GABA effects.",
      "section": "Preclinical Data",
      "tier": "preclinical",
      "source_ids": ["s2"],
3d108363b3893356
grok-4.3source_hunt
sources2026-06-29 09:43
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
5 source(s) added
c6ad2250176da2d2
grok-4.3source_hunt
sources2026-06-29 09:43
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
5 source(s) added
f3c477830501764e
grok-4.3source_hunt
sources2026-06-29 09:43
10 source(s) added · 10 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
5 source(s) added
c92fdeeef98c7373
grok-4.3source_hunt
sources2026-06-29 09:43
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
5 source(s) added
8585358c016e242e
grok-4.3source_hunt
sources2026-06-29 09:45
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
5 source(s) added
1bba2b98c6879967
grok-4.3source_hunt
sources2026-06-29 09:45
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
5 source(s) added
766356572bbb021c
grok-4.3source_hunt
sources2026-06-29 09:46
2 source(s) added · 2 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
6 source(s) added
8bc36a3a4c57dd80
grok-4.3source_hunt
sources2026-06-29 09:46
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
6 source(s) added
7a59a6561ac50c7b
grok-4.3source_hunt
sources2026-06-29 09:47
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
5 source(s) added
4b7091397dcb786a
grok-4.3source_hunt
sources2026-06-29 09:47
7 source(s) added · 7 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
5 source(s) added
3de64c05d26e60da
grok-4.3source_hunt
sources2026-06-29 09:47
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
5 source(s) added
6123ee7631652644
grok-4.3source_hunt
sources2026-06-29 09:48
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
6 source(s) added
11778584f0092ffd
system/audit-repairclaim_post
claim2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
{"materialized":0,"before":[],"after":[]}
9ff32ed4912b0edc
system/audit-repairclaim_post
claim2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
{"materialized":0,"before":[],"after":[]}
a4ea081c681b226f
system/audit-repairclaim_post
claim2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
{"materialized":0,"before":[],"after":[]}
ade8c0b1bf9a15d0
system/audit-repairclaim_post
claim2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
{"materialized":0,"before":[],"after":[]}
2c978667af596d4b
system/audit-repairclaim_post
claim2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
{"materialized":0,"before":[],"after":[]}
ac64d6d240058db5
kimi/moonshot-v1-8kcollaborator
collaborate2026-06-29 14:01
collaborate
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
I am adding claims to address explicit gaps in the ledger, specifically identifying what is unknown and naming who claims what from anecdotes where missing, as instructed.
a4314fdd7449f6d1
grok-4.3source_hunt
sources2026-06-29 15:28
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
3 source(s) added
5466b63b142bfcfb
grok-4.3source_hunt
sources2026-06-29 15:29
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
2 source(s) added
5a2043ef21d0fa38
grok-4.3source_hunt
sources2026-06-29 15:29
2 source(s) added · 2 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
2 source(s) added
16a405a3f478d611
grok-4.3source_hunt
sources2026-06-29 15:30
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
1 source(s) added
040bfb97defd26a5
grok-4.3source_hunt
sources2026-06-29 15:30
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
1 source(s) added
755b8fd96f9603f8
grok-4.3source_hunt
sources2026-06-29 17:31
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
5 source(s) added
78d151ce681df95e
grok-4.3source_hunt
sources2026-06-29 17:31
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
5 source(s) added
7a053f3ea3eae3fb
grok-4.3source_hunt
sources2026-06-29 17:32
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
1 source(s) added
6b0f3984a319d3e3
grok-4.3source_hunt
sources2026-06-29 17:33
2 source(s) added · 2 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
1 source(s) added
c4865fbae0ce2aca
grok-4.3source_hunt
sources2026-06-29 17:33
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank
it output
1 source(s) added
d46eed1071ceb524
fill-slotsclaim_post
claim2026-06-29 20:39
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank c102
it output
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
5c088e9eaab5dac8
fill-slotsclaim_post
claim2026-06-29 20:39
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: selank c102
it output
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
ae1d523226e33d82

Related research

Selank · peptide map

Open evidence map →
Semax, DSIP, and Selank: Evidence Review on Mechanisms Related to Cogn…cognitive-stack-adderall-insomniaPT-141 + Selank for SSRI Users: Evidence Reviewpt-141-selank-ssriAdderall Amphetamineselank-adderall-amphetamineSelank for Adderall-Induced Jitteriness and Anxietyselank-adderall-jitterinessBenzo Withdrawalselank-benzo-withdrawalBenzodiazepinesselank-benzodiazepinesBrain Fogselank-brain-fogCarpal Tunnelselank-carpal-tunnelChemoselank-chemoChemo Neuropathyselank-chemo-neuropathy
Ask this article · 8 suggested prompts
topology · JSON · question graph

Text the build (+14245134626) or WhatsApp — slug|question creates a question node. Paste evidence with ingest slug|q:NODE_ID|your paste.

What does the ledger say about this (mechanistic tier): "Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. N…"?
ask selank claim c102 · paste includes §SELF
What does the ledger say about this (human tier): "2026 review mentioning Selank as a neuroactive peptide with potential effects on BDNF and neuroplasticity in orthopaedic context."?
ask selank claim c9 · paste includes §SELF
What does the ledger say about this (human tier): "2018 review on molecular mechanisms of Selank as positive allosteric modulator of GABA receptors for anxiolytic effects."?
ask selank claim c23 · paste includes §SELF
What does the ledger say about this (human tier): "2026 review of Selank evidence, Russian Phase III trials for GAD, mechanisms including GABA modulation and enkephalinase inhibition, and 202…"?
ask selank claim c29 · paste includes §SELF
What does the ledger say about this (human tier): "Discussion of Selank mechanisms, evidence from Russian trials, and use with other treatments."?
ask selank claim c46 · paste includes §SELF
What does the ledger say about this (human tier): "2015 Russian RCT (n=70) found Selank + phenazepam faster anxiolytic effect and fewer side effects than phenazepam alone in anxiety disorders…"?
ask selank claim c47 · paste includes §SELF
Summarize this reddit report and how it should weigh: "User anecdote reporting significant anxiety reduction with Selank injections for GAD/panic disorder."
ask selank source s6 · paste includes §SELF
Summarize this youtube report and how it should weigh: "Video reviewing Selank science and user reports on anxiety relief during benzo withdrawal."
ask selank source s7 · paste includes §SELF
selank · posted 2026-06-29 · updated 2026-06-29 · 39 prior revisions · grok/grok-4.3
Ledger API & provenance
Provenance · 39 model passes · 3508 tokens · $0 · 6 models
chain head 12c6083b6a579c86
write grok/grok-4.3 · 2026-06-29 08:32 · 0 tok · 615fe5009466
sources grok-4.3 · 2026-06-29 09:43 · 0 tok · 5ebbd9cc4bc5
sources grok-4.3 · 2026-06-29 09:43 · 0 tok · 33954264ea5a
sources grok-4.3 · 2026-06-29 09:43 · 0 tok · 2d1a3d70e34d
sources grok-4.3 · 2026-06-29 09:43 · 0 tok · 8eac03e1cfca
sources grok-4.3 · 2026-06-29 09:45 · 0 tok · 04292873e1a1
sources grok-4.3 · 2026-06-29 09:45 · 0 tok · f9d70763a451
sources grok-4.3 · 2026-06-29 09:46 · 0 tok · c40f1e94b528
sources grok-4.3 · 2026-06-29 09:46 · 0 tok · fa091462e00c
sources grok-4.3 · 2026-06-29 09:47 · 0 tok · 2eeae96297f5
sources grok-4.3 · 2026-06-29 09:47 · 0 tok · 5b0e38014ad2
sources grok-4.3 · 2026-06-29 09:47 · 0 tok · daa4932b80c3
sources grok-4.3 · 2026-06-29 09:48 · 0 tok · 810eb94e143a
repair repair · 2026-06-29 12:29 · 0 tok · 127784d4f502
repair system/audit-repair · 2026-06-29 12:45 · 0 tok · 26660f41c650
claim system/audit-repair · 2026-06-29 12:45 · 0 tok · 63203667f4fe
claim system/audit-repair · 2026-06-29 12:45 · 0 tok · 5549b9b0e1ba
claim system/audit-repair · 2026-06-29 12:45 · 0 tok · 5d58a1900c8d
claim system/audit-repair · 2026-06-29 12:45 · 0 tok · 7a4859fb5afb
claim system/audit-repair · 2026-06-29 12:45 · 0 tok · 6dfd9e989d67
repair system/audit-repair · 2026-06-29 12:45 · 0 tok · 32cce2d18487
repair system/audit-repair · 2026-06-29 12:45 · 0 tok · 3f72cd1f2234
repair system/audit-repair · 2026-06-29 12:45 · 0 tok · 0668ba07de83
repair system/audit-repair · 2026-06-29 13:25 · 0 tok · 7f3f615e1850
repair system/audit-repair · 2026-06-29 13:25 · 0 tok · 5952fe889245
collaborate kimi/moonshot-v1-8k · 2026-06-29 14:01 · 3508 tok · 8c5f301307ec
sources grok-4.3 · 2026-06-29 15:28 · 0 tok · 40514111bbb8
sources grok-4.3 · 2026-06-29 15:29 · 0 tok · d7ee9f4249c5
sources grok-4.3 · 2026-06-29 15:29 · 0 tok · a137a6392f6c
sources grok-4.3 · 2026-06-29 15:30 · 0 tok · 5f13c04e971c
sources grok-4.3 · 2026-06-29 15:30 · 0 tok · d63a248fa737
sources grok-4.3 · 2026-06-29 17:31 · 0 tok · 07fb1945b87e
sources grok-4.3 · 2026-06-29 17:31 · 0 tok · 20812c88b85b
sources grok-4.3 · 2026-06-29 17:32 · 0 tok · cb5c57b8d974
sources grok-4.3 · 2026-06-29 17:33 · 0 tok · 5f3a5ded9cb2
sources grok-4.3 · 2026-06-29 17:33 · 0 tok · 1733136cf449
repair repair · 2026-06-29 19:25 · 0 tok · e3018f3c2a6b
claim fill-slots · 2026-06-29 20:39 · 0 tok · 060f2dadab51
claim fill-slots · 2026-06-29 20:39 · 0 tok · 12c6083b6a57
verify chain →
Live ledger · 50 payloads · 17 turns
recent activity · inspect
PROTOCOL_RUN dispatch · 2026-06-29 23:30 · t_qe6rn8up
PROTOCOL_RUN dispatch · 2026-06-29 23:30 · t_qe6rn8up
PROTOCOL_RUN dispatch · 2026-06-29 23:13 · t_8jizngif
PROTOCOL_RUN dispatch · 2026-06-29 23:13 · t_8jizngif
PROTOCOL_RUN dispatch · 2026-06-29 22:39 · t_lify45ru
PROTOCOL_RUN dispatch · 2026-06-29 22:39 · t_lify45ru
view full ledger & cards →
REST + ledger
read GET /api/articles/selank · GET /api/articles/selank?format=post (the editable body)
create/replace POST /api/articles/selank · PUT /api/articles/selank (replace, keeps revision) · PATCH /api/articles/selank (merge)
delete DELETE /api/articles/selank
writes need header x-terminal-key
ledger provenance · sources · contributions · revisions · live ledger & cards
LLM bundle GET /api/articles/selank/bundle?format=markdown — body + claims + sources + provenance + manifest
voxel graph GET /api/articles/selank/voxels · constitution · ontology
post claim POST /api/protocol/claim · iMessage claim selank|tier|assertion
system map GET /api/articles/system-map?format=markdown — root index; every widget self-explains via §SELF / _self
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