Evidence review

Semax: BDNF Upregulation

#peptide#semax
bundle · json · system map · manifest

Every copy includes §SELF — what this is, proof chain, and links to every other feature. No context required.

§SELF — this page explains the system
## §SELF — miscsubjects (paste without context)

**Principle:** Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.

**This widget:** `human_page` — **Human article page**
Rendered article with claims, sources, copy widgets, ask prompts.
- **article slug:** `semax`
- **contains:** rendered article, copy widgets, claims, sources, ask prompts
- **how to use:** Use Copy for LLM or Copy system map — both paste without context.
- **read:** https://miscsubjects.com/a/semax

### Logical proof (verify each step)
1. Articles are voxel graphs of tiered claims, not prose blobs. → https://miscsubjects.com/api/articles/constitution
2. Claims link to hash-chained sources via source_ids. → https://miscsubjects.com/api/articles/semax/sources
3. Ask reads topology; ingest/claim append to ledger. → https://miscsubjects.com/api/protocol
4. Models queue growth: populate → collaborate → repair → reflex. → https://miscsubjects.com/api/protocol/grow
5. Graph proves its own shape (reflex) and $/claim (yield). → https://miscsubjects.com/graph.html?layer=reflex
6. Full feature index + _explain on every API response. → https://miscsubjects.com/api/articles/system-map

### Related features (explains other parts of the system)
- **bundle** — Paste-ready package: body + claims + sources + voxels + provenance + manifest + constitution. · https://miscsubjects.com/api/articles/semax/bundle?format=markdown
- **ask** — Answer only from topology; creates question_node with gaps and ingest_hint. · https://miscsubjects.com/api/articles/semax/prompts
- **topology** — Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER. · https://miscsubjects.com/api/articles/semax/topology

### Full index
- JSON: https://miscsubjects.com/api/articles/system-map
- Markdown: https://miscsubjects.com/api/articles/system-map?format=markdown

*Not medical advice. Tier-honest. Cite claim/source ids.*

Regeneration vs degeneration — where this fits

The body is always doing two things at once: breaking down (degeneration) and building back (regeneration). A condition persists when breakdown outruns repair. Most drugs used for symptoms suppress a signal (pain, acid, anxiety, inflammation) without fixing the tissue that caused the signal. Peptides in this ledger are studied for repair pathways: new blood vessels, repair-cell migration, nerve regrowth, gut lining, neural connections. This article maps one compound through that frame — what it is, how it is proposed to work, what evidence exists, and what people report.

This topic: Semax is studied for neural support — BDNF and related pathways in brain tissue. Cognitive and recovery claims map to regenerating or protecting neural connections, not sedating a symptom.

What it is

Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only. In a study of 110 patients after ischemic stroke, Semax increased plasma BDNF levels.

How it works

Step logic:

  1. Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
  2. In a study of 110 patients after ischemic stroke, Semax increased plasma BDNF levels.
  3. 2026 review mentioning Semax in context of neuroactive peptides for orthopaedics.
  4. June 2026 article reviewing Semax evidence for ADHD, noting limited human data and mechanisms like BDNF and dopamine.
  5. In rat hippocampus, a single intranasal dose of Semax (50 μg/kg) produced a maximal 1.4-fold increase in BDNF protein levels, accompanied by increased trkB phosphorylation and mRNA expression.
  6. 2024 study showing Semax exerts antidepressant-like effects in a chronic unpredictable stress rat model, reversing anhedonia and restoring hippocampal BDNF levels.
  7. 2020 study examining Semax (with Selank) effects on brain functional connectivity via fMRI.
  8. Alzheimer's Drug Discovery Foundation researcher summary of available evidence on Semax for cognition, noting Russian use in stroke and limited healthy-subject data.

Why it would work (logic chain)

  1. IF Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  2. IF In a study of 110 patients after ischemic stroke, Semax increased plasma BDNF levels. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  3. IF 2026 review mentioning Semax in context of neuroactive peptides for orthopaedics. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  4. IF June 2026 article reviewing Semax evidence for ADHD, noting limited human data and mechanisms like BDNF and dopamine. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  5. IF In rat hippocampus, a single intranasal dose of Semax (50 μg/kg) produced a maximal 1.4-fold increase in BDNF protein levels, accompanied by increased trkB phosphorylation and mRNA expression. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).
  6. IF 2024 study showing Semax exerts antidepressant-like effects in a chronic unpredictable stress rat model, reversing anhedonia and restoring hippocampal BDNF levels. THEN that is one proposed link in a repair/regeneration pathway (not yet proven end-to-end in humans unless a human claim says so).

Why people take it

Reasons that appear in this ledger:

  1. Positive acute effects on focus/anxiety but tolerance develops after 2-3 weeks requiring cycling.
  2. User reports strong positive focus boost for short periods but notes it interferes with sleep if used later in the day.
  3. Negative experience: only migraine reported, calls it overrated.
  4. Neutral to positive: minimal side effects in trial, switched to as-needed use.
  5. User reports feeling amazing with no side effects from daily subQ 1mg Semax + 1mg Selank.
  6. User reports severe negative outcome after two 30-day periods of Semax use, lasting effects for a year.
  7. User calls Semax their saving grace recently.
  8. User reports no Adderall-like effects from Semax.
  9. User liked Semax effects but reported hair loss as a negative outcome.
  10. Mixed/negative on Semax (minimal effect even at 1mg), positive on Selank for deep sleep.

How many people take it

There is no reliable global count of how many people take this compound. That number is not in this ledger.

What we can count from this ledger:

  • 68 anecdote source(s) (posts, threads, comments)
  • 68 anecdote-tier claim(s) derived from them

Logic: 68 online report(s) are catalogued here. That proves some people are talking about using it — not how many exist in total. Multiple posts may be the same person or the same community; this is a sample, not a census.

Evidence inventory

This is a count of what is in this ledger — not a claim about all research worldwide.

  • Scientific sources catalogued (PubMed, trials, reviews): 32
  • Claims tagged human evidence: 8
  • Claims tagged preclinical (animal/lab): 6
  • Claims tagged anecdotal: 68
  • Reddit posts catalogued: 39
  • X posts catalogued: 24
  • Other anecdote sources (YouTube, Instagram, etc.): 5
  • Total sources in chain: 102

Quantified confidence (this ledger): 0.95 / 1.00 — moderate — human claims present in ledger

Formula: human claims×0.12 + preclinical×0.04 + anecdote×0.015 + studies (capped). This is not clinical certainty — it measures how much graded evidence is catalogued here.

What scientists say

Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus (source s1)

2006 rat study showing Semax increases hippocampal BDNF and trkB.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

The efficacy of semax in the treatment of patients at the early and late stages of rehabilitation after ischemic stroke (source s2)

2018 human study in 110 stroke patients showing Semax raises plasma BDNF.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease (source s3)

2025 study showing Semax improves cognitive functions in transgenic Alzheimer's disease mouse model.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice (source s4)

2025 study on Semax for spinal cord injury recovery in mice.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

Therapeutic Peptides in Orthopaedics: Applications, ... (source s5)

2026 review mentioning Semax in context of neuroactive peptides for orthopaedics.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease (source s6)

Full text of 2025 Acta Naturae paper on Semax in AD mouse model.

Evidence type: Published research.

Effects of Semax on the Default Mode Network of the Brain (source s9)

2018 study using resting-state fMRI on healthy volunteers showing Semax increases volume in the rostral default mode network subcomponent compared to placebo.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Semax for Parkinson's Neuroprotection: A Qualitative Literature Review (source s10)

2025 qualitative review of rodent studies on Semax for Parkinson's-like models, noting anxiolytic effects but inconsistent motor benefits and lack of human PD trials.

Evidence type: Published research.

Semax Peptide: Benefits, Safety & Buying Advice [2026] (source s11)

2026 comprehensive review covering mechanisms, animal and limited human studies on Semax for cognition, neuroprotection, and mood.

Evidence type: Published research.

Semax Cognitive Vitality For Researchers (source s12)

Alzheimer's Drug Discovery Foundation researcher summary of available evidence on Semax for cognition, noting Russian use in stroke and limited healthy-subject data.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress (source s22)

2024 study showing Semax exerts antidepressant-like effects in a chronic unpredictable stress rat model, reversing anhedonia and restoring hippocampal BDNF levels.

Evidence type: Animal or lab work — shows mechanism or early signal, not proof in people.

Semax Peptide: Benefits, Dosage & Nasal Spray | Rite Aid (source s25)

Medical overview of Semax as a Russian-approved nootropic peptide, noting its 2026 FDA regulatory status changes for compounding, benefits for cognition and neuroprotection, and administration methods.

Evidence type: Published research.

The Effect of Peptide Semax, an ACTH(4-10) Analogue, on the Expression of Genes Encoding Neurotrophic Factors in the Rat Brain (source s27)

2025 review/paper on Semax effects on gene expression for neurotrophic factors in rat brain, referencing its nootropic and neurotransmitter-modulating properties.

Evidence type: Published research.

Semax, a Copper Chelator Peptide, Decreases the Cu(II) ... (source s28)

2025 study on Semax as copper chelator and potential in neurodegenerative disorders.

Evidence type: Published research.

Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice (source s29)

2025 research article on Semax effects on spinal cord injury recovery in mice via Oprm1.

Evidence type: Published research.

The Effect of Peptide Semax, an ACTH(4-10) Analogue, on ... (source s30)

2025 study on Semax effects on calcium fluctuations in neurons.

Evidence type: Published research.

Semax Peptide Dosage Guide: Benefits, Safety & Best Practices (source s33)

2026 guide on Semax dosage, benefits, and FDA-related updates.

Evidence type: Published research.

Therapeutic peptides in gerontology: mechanisms and clinical applications (source s41)

Review of therapeutic peptides including Semax for neuroprotection in aging/gerontology contexts.

Evidence type: Tagged human evidence in this ledger — check sample size and design.

What people say on Reddit

My experience with semax an how it's helped me — Reddit, r/Nootropics (source s7)

User anecdote on improved focus, memory, and performance with Semax nasal spray.

My Semax Experience: Injectable vs Nasal — Reddit, r/Nootropics (source s13)

2026 Reddit user anecdote comparing nasal vs subQ injectable Semax, reporting better consistency and sustained focus with injectable at 400mcg/day 4 days/week.

Long term effects of Semax? Experiences? — Reddit, r/Nootropics (source s14)

Multiple user anecdotes on long-term or post-use effects of Semax, with reports of lasting cognitive improvements or benefits persisting after cessation.

Experience with Semax : r/Nootropics — Reddit, r/Nootropics (source s15)

User reports positive experience with Semax for brain fog and cognitive issues.

Semax nasal spray life changing have my memory back — Reddit, r/TBI (source s16)

TBI patient reports memory improvement and reduced brain fog with Semax nasal spray and amidate version; positive long-term feel.

Semax side effects after one day : r/Nootropics — Reddit, r/Nootropics (source s17)

User reports initial overstimulation followed by grogginess, headache, and fatigue after high first dose of nasal Semax; comments include positive subq experiences and vision side effect report.

Has anyone tried Semax and Selank Stack? : r/Biohackers — Reddit, r/Biohackers (source s18)

Mixed user reports: some positive focus/ADHD benefits and longer lasting with NA version; others subtle or no effect from stack.

Semax has actual human clinical data but it's all from ... — Reddit, r/Nootropics (source s24)

2026 Reddit discussion highlighting existing Russian human clinical/observational data on Semax for stroke and cognitive issues.

Semax spray - 0.1% or 1%? And which dose? — Reddit, r/Nootropics (source s26)

User discussion on Semax nasal spray concentrations, with comments recommending 0.1% for nootropic use in healthy people and 1% for stroke/TBI recovery, including dosing advice from Russian sources.

What Semax actually is, and what the research really shows — Reddit, r/NTNPerformance (source s31)

2026 Reddit post discussing Semax research and effects.

Has anyone tried Semax nasal spray before ? This was my ... — Reddit, r/USPeptides (source s34)

Positive user report on nasal Semax improving mental clarity and focus.

Semax effects on emotions : r/Nootropics — Reddit, r/Nootropics (source s35)

Initial good effects on focus/energy then negative emotional blunting from subQ Semax.

Selank + Semax – Observed Effects (Focus, Anxiety, Sleep, ... — Reddit, r/Nootropics (source s36)

Detailed positive observations on focus, reduced anxiety from Semax/Selank stack.

About to start Semax peptide : r/Epilepsy — Reddit, r/Epilepsy (source s37)

Positive post-use report on improved memory, focus, and speech after seizures.

Semax giving me neutral and short-lived symptoms? What ... — Reddit, r/Nootropics (source s38)

Mixed/neutral experience with short-lived sensory boost followed by tiredness/crash.

Semax: Comprehensive Guide — Reddit, r/APRHealthSolutions (source s49)

Reddit post providing overview of Semax research and uses.

What people say on X

My first day using Semax — X (source s19)

Neuroscientist user reports acute mental clarity, visual sharpness, smooth nootropic effect lasting hours without crash on first day of Semax.

Semax peptide experience — X (source s20)

User reports strong cognitive benefits, clean focus, BDNF upregulation feel, 24h activity from nasal spray, pairs well with others.

My take on Semax — X (source s39)

Positive acute effects on focus/anxiety but tolerance develops after 2-3 weeks requiring cycling.

Semax clarification — X (source s40)

Personal daily use report emphasizing subjective positive cognitive effects.

Peptide Confessions user report on Semax — X (source s60)

User reports strong positive focus boost for short periods but notes it interferes with sleep if used later in the day.

X user report on Semax side effects — X (source s61)

Negative experience: only migraine reported, calls it overrated.

X user trial of Semax — X (source s62)

Neutral to positive: minimal side effects in trial, switched to as-needed use.

X post on Semax/Selank stack — X (source s66)

User reports feeling amazing with no side effects from daily subQ 1mg Semax + 1mg Selank.

Semax dosing and effects comparison — X (source s73)

User describes sustained focus from subQ Semax vs shorter intranasal effects; positive outcome.

X post about zero effects from Semax — X (source s76)

User reports feeling no effects from Semax despite expectations.

X post about negative long-term effects from Semax — X (source s77)

User reports severe negative outcome after two 30-day periods of Semax use, lasting effects for a year.

X post by @isaacbklein — X (source s80)

User reports no Adderall-like effects from Semax.

X post by @RNR_0 — X (source s81)

User includes Semax in a stack for focus/edge off with other compounds, positive context implied.

X post on Semax experience and side effect — X (source s84)

User liked Semax effects but reported hair loss as a negative outcome.

X post on Semax/Selank personal trial — X (source s85)

Mixed/negative on Semax (minimal effect even at 1mg), positive on Selank for deep sleep.

Fitcap on injectable Semax/Selank — X (source s86)

Initial positive effects on focus and calm but rapid tolerance build-up with daily injectable use.

Other anecdote evidence

Why SEMAX Is the Peptide Everyone's Talking About for ... — YouTube (source s8)

YouTube video discussing Semax benefits for cognition.

I Tried Semax... Here's What Happened! — YouTube (source s21)

Video review of personal Semax trial including benefits experienced and reasons for stopping use.

Why SEMAX Is the Peptide Everyone's Talking About for Focus Without Stimulants — YouTube (source s23)

2026 video by Dr. Debra Durst explaining Semax (referred to as CAX) mechanisms via BDNF and neuroplasticity for focus, learning, and mental clarity without stimulant effects.

Semax Results (No One Talks About These Benefits) — YouTube (source s32)

2025 YouTube video on Semax benefits for focus, memory, mental clarity.

Instagram reel on Semax — online (source s78)

User calls Semax their saving grace recently.

What we do not know

  1. There is a lack of longitudinal studies examining the long-term effects of Semax on BDNF levels and cognitive function.

Safety and limits

  1. Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.

---

Not medical advice. Counts and quotes are from this article's hash-chained ledger. Anecdote = real reports, not proof. Animal studies ≠ human proof.

Semax · peptide map

Evidence map

Hover a node — its path lights up. Click to open the article.

Full map →
JumpSemax, DSIP, and Selank: Evidence Review on Mechanisms Related to Cogn… · 6 humanSemax and BDNF Upregulation: Preclinical and Limited Human Data · 5 humanAdderall AmphetamineBenzo Withdrawal
Evidence · 102 sources · swipe →chain 4db8b169bb6f · verify chain · provenance
1 / 102
Evidence ledger 103 · tier-ranked · API
mechanistic
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
human
In a study of 110 patients after ischemic stroke, Semax increased plasma BDNF levels.
sources: s2
human
2026 review mentioning Semax in context of neuroactive peptides for orthopaedics.
sources: s5
human
2018 study using resting-state fMRI on healthy volunteers showing Semax increases volume in the rostral default mode network subcomponent compared to placebo.
sources: s9
human
Review of therapeutic peptides including Semax for neuroprotection in aging/gerontology contexts.
sources: s41
84 more ranked claims
human0.80
June 2026 article reviewing Semax evidence for ADHD, noting limited human data and mechanisms like BDNF and dopamine.
grok/grok-4.3
Materialized from orphan source s52 by ledger repair
sources: s52
human0.80
Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.
system/protocol
Required constitution slot: disclaimer
preclinical0.50
In rat hippocampus, a single intranasal dose of Semax (50 μg/kg) produced a maximal 1.4-fold increase in BDNF protein levels, accompanied by increased trkB phosphorylation and mRNA expression.
system/repair
Core rat data establishing BDNF upregulation mechanism.
sources: s1
preclinical0.50
2024 study showing Semax exerts antidepressant-like effects in a chronic unpredictable stress rat model, reversing anhedonia and restoring hippocampal BDNF levels.
grok/grok-4.3
Materialized from orphan source s22 by ledger repair
sources: s22
preclinical0.50
There is a lack of longitudinal studies examining the long-term effects of Semax on BDNF levels and cognitive function.
kimi-collaborator
This claim identifies a specific gap in knowledge regarding the long-term effects of Semax, which is not addressed by the current claims in the ledger.
sources: s1
preclinical0.50
2024 study using RNA-Seq showing Semax and related peptide compensate gene expression changes from ischemia in rat brain at 24h post-stroke, affecting immune, neurosignaling, neurogenesis, and angiogenesis pathways.
grok-4.3
Materialized from orphan source s59 by ledger repair
sources: s59
system0.35
Semax: BDNF Upregulation is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.
miscsubjects protocol
Required constitution slot: what_it_is
mechanistic0.30
2020 study examining Semax (with Selank) effects on brain functional connectivity via fMRI.
grok-4.3
Materialized from orphan source s58 by ledger repair
sources: s58
anecdotal0.30
Positive acute effects on focus/anxiety but tolerance develops after 2-3 weeks requiring cycling.
grok/grok-4.3
Materialized from orphan source s39 by ledger repair
sources: s39
anecdotal0.30
User reports strong positive focus boost for short periods but notes it interferes with sleep if used later in the day.
grok-4.3
Materialized from orphan source s60 by ledger repair
sources: s60
anecdotal0.30
Negative experience: only migraine reported, calls it overrated.
grok-4.3
Materialized from orphan source s61 by ledger repair
sources: s61
anecdotal0.30
Neutral to positive: minimal side effects in trial, switched to as-needed use.
grok-4.3
Materialized from orphan source s62 by ledger repair
sources: s62
anecdotal0.30
User reports feeling amazing with no side effects from daily subQ 1mg Semax + 1mg Selank.
grok-4.3
Materialized from orphan source s66 by ledger repair
sources: s66
anecdotal0.30
User reports severe negative outcome after two 30-day periods of Semax use, lasting effects for a year.
grok-4.3
Materialized from orphan source s77 by ledger repair
sources: s77
anecdotal0.30
User calls Semax their saving grace recently.
grok-4.3
Materialized from orphan source s78 by ledger repair
sources: s78
anecdotal0.30
User reports no Adderall-like effects from Semax.
grok-4.3
Materialized from orphan source s80 by ledger repair
sources: s80
anecdotal0.30
User liked Semax effects but reported hair loss as a negative outcome.
grok-4.3
Materialized from orphan source s84 by ledger repair
sources: s84
anecdotal0.30
Mixed/negative on Semax (minimal effect even at 1mg), positive on Selank for deep sleep.
grok-4.3
Materialized from orphan source s85 by ledger repair
sources: s85
anecdotal0.30
Initial positive effects on focus and calm but rapid tolerance build-up with daily injectable use.
grok-4.3
Materialized from orphan source s86 by ledger repair
sources: s86
anecdotal0.30
X post discussing Semax + Selank stack for cognitive benefits in high-performance contexts (anecdotal context).
grok-4.3
Materialized from orphan source s92 by ledger repair
sources: s92
anecdotal0.30
X post anecdotal daily dosing of 1mg Semax + 1mg Selank (anecdotal, not advice).
grok-4.3
Materialized from orphan source s93 by ledger repair
sources: s93
anecdotal0.30
X post grading Semax evidence levels in context of potential compounding discussions.
grok-4.3
Materialized from orphan source s94 by ledger repair
sources: s94
human0.22low confidence
Alzheimer's Drug Discovery Foundation researcher summary of available evidence on Semax for cognition, noting Russian use in stroke and limited healthy-subject data.
grok/grok-4.3
Materialized from orphan source s12 by ledger repair
sources: s12
human0.22low confidence
Discusses safety, efficacy and dosing of Semax.
grok/grok-4.3
Materialized from orphan source s43 by ledger repair
sources: s43
preclinical0.22low confidence
2025 study showing Semax improves cognitive functions in transgenic Alzheimer's disease mouse model.
grok/grok-4.3
Materialized from orphan source s3 by ledger repair
sources: s3
preclinical0.22low confidence
2025 study on Semax for spinal cord injury recovery in mice.
grok/grok-4.3
Materialized from orphan source s4 by ledger repair
sources: s4
mechanistic0.22low confidence
2025 study on Semax as copper chelator and potential in neurodegenerative disorders.
grok/grok-4.3
Materialized from orphan source s28 by ledger repair
sources: s28
mechanistic0.22low confidence
2025 study on Semax effects on calcium fluctuations in neurons.
grok/grok-4.3
Materialized from orphan source s30 by ledger repair
sources: s30
mechanistic0.22low confidence
2007 hypothesis paper proposing Semax for ADHD and Rett syndrome based on its mechanisms.
grok/grok-4.3
Materialized from orphan source s51 by ledger repair
sources: s51
mechanistic0.22low confidence
2022 study showing Semax interferes with copper-induced amyloid beta aggregation, relevant to Alzheimer's.
grok-4.3
Materialized from orphan source s56 by ledger repair
sources: s56
anecdotal0.22low confidence
User anecdote on improved focus, memory, and performance with Semax nasal spray.
grok/grok-4.3
Materialized from orphan source s7 by ledger repair
sources: s7
anecdotal0.22low confidence
YouTube video discussing Semax benefits for cognition.
grok/grok-4.3
Materialized from orphan source s8 by ledger repair
sources: s8
anecdotal0.22low confidence
2026 Reddit user anecdote comparing nasal vs subQ injectable Semax, reporting better consistency and sustained focus with injectable at 400mcg/day 4 days/week.
grok/grok-4.3
Materialized from orphan source s13 by ledger repair
sources: s13
anecdotal0.22low confidence
Multiple user anecdotes on long-term or post-use effects of Semax, with reports of lasting cognitive improvements or benefits persisting after cessation.
grok/grok-4.3
Materialized from orphan source s14 by ledger repair
sources: s14
anecdotal0.22low confidence
User reports positive experience with Semax for brain fog and cognitive issues.
grok/grok-4.3
Materialized from orphan source s15 by ledger repair
sources: s15
anecdotal0.22low confidence
TBI patient reports memory improvement and reduced brain fog with Semax nasal spray and amidate version; positive long-term feel.
grok/grok-4.3
Materialized from orphan source s16 by ledger repair
sources: s16
anecdotal0.22low confidence
User reports initial overstimulation followed by grogginess, headache, and fatigue after high first dose of nasal Semax; comments include positive subq experiences and vision side effect report.
grok/grok-4.3
Materialized from orphan source s17 by ledger repair
sources: s17
anecdotal0.22low confidence
Mixed user reports: some positive focus/ADHD benefits and longer lasting with NA version; others subtle or no effect from stack.
grok/grok-4.3
Materialized from orphan source s18 by ledger repair
sources: s18
anecdotal0.22low confidence
Neuroscientist user reports acute mental clarity, visual sharpness, smooth nootropic effect lasting hours without crash on first day of Semax.
grok/grok-4.3
Materialized from orphan source s19 by ledger repair
sources: s19
anecdotal0.22low confidence
User reports strong cognitive benefits, clean focus, BDNF upregulation feel, 24h activity from nasal spray, pairs well with others.
grok/grok-4.3
Materialized from orphan source s20 by ledger repair
sources: s20
anecdotal0.22low confidence
Video review of personal Semax trial including benefits experienced and reasons for stopping use.
grok/grok-4.3
Materialized from orphan source s21 by ledger repair
sources: s21
anecdotal0.22low confidence
2026 video by Dr. Debra Durst explaining Semax (referred to as CAX) mechanisms via BDNF and neuroplasticity for focus, learning, and mental clarity without stimulant effects.
grok/grok-4.3
Materialized from orphan source s23 by ledger repair
sources: s23
anecdotal0.22low confidence
User discussion on Semax nasal spray concentrations, with comments recommending 0.1% for nootropic use in healthy people and 1% for stroke/TBI recovery, including dosing advice from Russian sources.
grok/grok-4.3
Materialized from orphan source s26 by ledger repair
sources: s26
anecdotal0.22low confidence
2026 Reddit post discussing Semax research and effects.
grok/grok-4.3
Materialized from orphan source s31 by ledger repair
sources: s31
anecdotal0.22low confidence
2025 YouTube video on Semax benefits for focus, memory, mental clarity.
grok/grok-4.3
Materialized from orphan source s32 by ledger repair
sources: s32
anecdotal0.22low confidence
Positive user report on nasal Semax improving mental clarity and focus.
grok/grok-4.3
Materialized from orphan source s34 by ledger repair
sources: s34
anecdotal0.22low confidence
Initial good effects on focus/energy then negative emotional blunting from subQ Semax.
grok/grok-4.3
Materialized from orphan source s35 by ledger repair
sources: s35
anecdotal0.22low confidence
Detailed positive observations on focus, reduced anxiety from Semax/Selank stack.
grok/grok-4.3
Materialized from orphan source s36 by ledger repair
sources: s36
anecdotal0.22low confidence
Positive post-use report on improved memory, focus, and speech after seizures.
grok/grok-4.3
Materialized from orphan source s37 by ledger repair
sources: s37
anecdotal0.22low confidence
Mixed/neutral experience with short-lived sensory boost followed by tiredness/crash.
grok/grok-4.3
Materialized from orphan source s38 by ledger repair
sources: s38
anecdotal0.22low confidence
Personal daily use report emphasizing subjective positive cognitive effects.
grok/grok-4.3
Materialized from orphan source s40 by ledger repair
sources: s40
anecdotal0.22low confidence
Reddit post providing overview of Semax research and uses.
grok/grok-4.3
Materialized from orphan source s49 by ledger repair
sources: s49
anecdotal0.22low confidence
2026 Reddit anecdotes on Semax with stimulants, mixed experiences on cognition and side effects.
grok/grok-4.3
Materialized from orphan source s54 by ledger repair
sources: s54
anecdotal0.22low confidence
Anecdotal reports suggest that Semax may improve cognitive function and mood, but these claims lack rigorous scientific validation.
kimi-collaborator
This claim identifies anecdotal claims about Semax's effects, which are not currently represented in the ledger, and highlights the lack of scientific validation for these claims.
sources: s7
anecdotal0.22low confidence
User reports possible mild motivational effect from 250mcg subQ Semax, questioning if real or placebo; notes brain fog and tiredness improved enough to start tasks.
grok-4.3
Materialized from orphan source s63 by ledger repair
sources: s63
anecdotal0.22low confidence
User reports passing out after increasing Semax dose to 500mcg, seeking experiences on side effects.
grok-4.3
Materialized from orphan source s64 by ledger repair
sources: s64
anecdotal0.22low confidence
Positive user report of strong benefits from Semax after 3 days at 200mcg twice daily.
grok-4.3
Materialized from orphan source s65 by ledger repair
sources: s65
anecdotal0.22low confidence
User reports accidental high dose of Semax (with Selank) led to long-term reduction in anxiety and depression sensitivity, emotional stabilization, positive brain chemistry change; notes it was life-altering but suggests microbiome focus instead.
grok-4.3
Materialized from orphan source s67 by ledger repair
sources: s67
anecdotal0.22low confidence
Positive user experience with subQ Semax at 700mcg daily: increased sharpness, alertness, cognitive function after finding proper dose; no tolerance mentioned over 2 months.
grok-4.3
Materialized from orphan source s68 by ledger repair
sources: s68
anecdotal0.22low confidence
Negative experience: nasal Semax provides strong morning focus but causes intense afternoon fatigue/crash worse than Adderall comedown.
grok-4.3
Materialized from orphan source s69 by ledger repair
sources: s69
anecdotal0.22low confidence
User reports negative mood effects (moody, down) at low 200mcg dose of Semax.
grok-4.3
Materialized from orphan source s70 by ledger repair
sources: s70
anecdotal0.22low confidence
User reports Semax helped with brain fog and trauma-related stress in r/Semax subreddit.
grok-4.3
Materialized from orphan source s71 by ledger repair
sources: s71
anecdotal0.22low confidence
User seeking or reporting on Semax for long-term depression, memory, and fatigue issues.
grok-4.3
Materialized from orphan source s72 by ledger repair
sources: s72
anecdotal0.22low confidence
User describes sustained focus from subQ Semax vs shorter intranasal effects; positive outcome.
grok-4.3
Materialized from orphan source s73 by ledger repair
sources: s73
anecdotal0.22low confidence
Discussion of Semax benefits for memory and cognitive resilience alongside caveats.
grok-4.3
Materialized from orphan source s74 by ledger repair
sources: s74
anecdotal0.22low confidence
User asks about using Semax/Selank when sleep deprived; comment suggests it might help combat drowsiness.
grok-4.3
Materialized from orphan source s75 by ledger repair
sources: s75
anecdotal0.22low confidence
User reports feeling no effects from Semax despite expectations.
grok-4.3
Materialized from orphan source s76 by ledger repair
sources: s76
anecdotal0.22low confidence
User asking for experiences with Semax nasal spray or vials for cognitive enhancement; new subreddit post not previously collected.
grok-4.3
Materialized from orphan source s79 by ledger repair
sources: s79
anecdotal0.22low confidence
User includes Semax in a stack for focus/edge off with other compounds, positive context implied.
grok-4.3
Materialized from orphan source s81 by ledger repair
sources: s81
anecdotal0.22low confidence
Forum discussion on sourcing and experiences with Semax nasal spray; user experiences on effects and vendors.
grok-4.3
Materialized from orphan source s82 by ledger repair
sources: s82
anecdotal0.22low confidence
User with ADHD, anxiety, depression reports profound positive effects from single 0.3mg dose of Semax: relief, clarity, quiet mind. Notes return of symptoms off it; seeks long-term safety info.
grok-4.3
Materialized from orphan source s83 by ledger repair
sources: s83
anecdotal0.22low confidence
User shares personal log of using Semax for anhedonia, anxiety, and depression symptoms.
grok-4.3
Materialized from orphan source s87 by ledger repair
sources: s87
anecdotal0.22low confidence
User reports strong positive cognitive/motivational effects from long-term nasal Semax but also notes drawbacks like detachment and Spock-like emotional flattening.
grok-4.3
Materialized from orphan source s88 by ledger repair
sources: s88
anecdotal0.22low confidence
New user in r/Semax sharing interest and starting experience for ADHD-related benefits.
grok-4.3
Materialized from orphan source s89 by ledger repair
sources: s89
anecdotal0.22low confidence
User reports positive experience with homemade Semax nasal spray, rating it highly (8/10) after trying subQ with zero impact.
grok-4.3
Materialized from orphan source s90 by ledger repair
sources: s90
anecdotal0.22low confidence
Positive anecdotal report of sustained focus, clarity, and mood boost from nasal Semax 800mcg.
grok-4.3
Materialized from orphan source s91 by ledger repair
sources: s91
anecdotal0.22low confidence
Guide discusses early onset of anecdotal effects like clarity and focus from nasal Semax/Selank stack.
grok-4.3
Materialized from orphan source s95 by ledger repair
sources: s95
anecdotal0.22low confidence
Post warns on context for use, emphasizing foundational habits; notes BDNF effects anecdotally.
grok-4.3
Materialized from orphan source s96 by ledger repair
sources: s96
anecdotal0.22low confidence
Discussion on regulatory status of Semax for compounding; no personal outcomes reported.
grok-4.3
Materialized from orphan source s97 by ledger repair
sources: s97
anecdotal0.22low confidence
User reports negative side effect of brain fog from NA Semax Amidate nasal spray (anecdotal).
grok-4.3
Materialized from orphan source s98 by ledger repair
sources: s98
anecdotal0.22low confidence
Thread discussing divided opinions on Semax efficacy and controversy.
grok-4.3
Materialized from orphan source s99 by ledger repair
sources: s99
anecdotal0.22low confidence
Overview post on Semax history and research origins (mostly Eastern Europe/Russia). No personal outcomes or dosing here.
grok-4.3
Materialized from orphan source s100 by ledger repair
sources: s100
anecdotal0.22low confidence
User starting Semax + Selank stack, seeking protocols (anecdotal interest, no specific outcomes/sides reported).
grok-4.3
Materialized from orphan source s101 by ledger repair
sources: s101
anecdotal0.22low confidence
Vendor post claiming positive user feedback on their Semax nasal spray (anecdotal vendor claim).
grok-4.3
Materialized from orphan source s102 by ledger repair
sources: s102
Low-confidence / auto-generated 14
speculative0.12
Commercial vendors and clinics market this compound (5 commercial/clinic sources catalogued) — marketing material, not evidence.
commercial vendors
Collapsed 10 duplicate marketing claims
sources: s24, s48, s53, s55, s57
speculative0.12
Full text of 2025 Acta Naturae paper on Semax in AD mouse model.
grok/grok-4.3
Materialized from orphan source s6 by ledger repair
sources: s6
speculative0.12low confidence
2025 qualitative review of rodent studies on Semax for Parkinson's-like models, noting anxiolytic effects but inconsistent motor benefits and lack of human PD trials.
grok/grok-4.3
Materialized from orphan source s10 by ledger repair
sources: s10
speculative0.12
2026 comprehensive review covering mechanisms, animal and limited human studies on Semax for cognition, neuroprotection, and mood.
grok/grok-4.3
Materialized from orphan source s11 by ledger repair
sources: s11
speculative0.12
Medical overview of Semax as a Russian-approved nootropic peptide, noting its 2026 FDA regulatory status changes for compounding, benefits for cognition and neuroprotection, and administration methods.
grok/grok-4.3
Materialized from orphan source s25 by ledger repair
sources: s25
speculative0.12
2025 review/paper on Semax effects on gene expression for neurotrophic factors in rat brain, referencing its nootropic and neurotransmitter-modulating properties.
grok/grok-4.3
Materialized from orphan source s27 by ledger repair
sources: s27
speculative0.12
2025 research article on Semax effects on spinal cord injury recovery in mice via Oprm1.
grok/grok-4.3
Materialized from orphan source s29 by ledger repair
sources: s29
speculative0.12
2026 guide on Semax dosage, benefits, and FDA-related updates.
grok/grok-4.3
Materialized from orphan source s33 by ledger repair
sources: s33
speculative0.12
Updates on Semax regulatory status in US as of 2026.
grok/grok-4.3
Materialized from orphan source s42 by ledger repair
sources: s42
speculative0.12
Reviews mechanisms and potential benefits of Semax including BDNF/NGF upregulation.
grok/grok-4.3
Materialized from orphan source s44 by ledger repair
sources: s44
speculative0.12
Overview of Semax benefits, legal status (noted as withdrawn from FDA Category 2 as of April 2026).
grok/grok-4.3
Materialized from orphan source s45 by ledger repair
sources: s45
speculative0.12
Official FDA advisory committee meeting agenda including Semax for potential inclusion on 503A bulks list for cerebral ischemia, migraine, and trigeminal neuralgia.
grok/grok-4.3
Materialized from orphan source s46 by ledger repair
sources: s46
speculative0.12
2026 guide on Semax status, benefits, and research summary.
grok/grok-4.3
Materialized from orphan source s47 by ledger repair
sources: s47
speculative0.12
2022 study on Semax inhibiting amyloid-beta copper complex fibrillogenesis, relevant to Alzheimer's neuroprotection.
grok/grok-4.3
Materialized from orphan source s50 by ledger repair
sources: s50
Model swipes · 36 from 5 models · swipe →verify
1 / 36
grok/grok-4.3writer
redraft2026-06-29 08:32
Semax: BDNF Upregulation · 3 claims · 2 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):
BPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).
TB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.
ARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.
Semax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.
Selank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).
PT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).
DSIP — Del
it output
{
  "slug": "semax-bdnf-upregulation",
  "title": "Semax: BDNF Upregulation",
  "body": "## Overview\nSemax is described as a brain peptide that upregulates BDNF.\n\n## Preclinical Evidence (Rat Studies)\nIn rat hippocampus, a single intranasal dose of Semax (50 μg/kg) produced a maximal 1.4-fold increase in BDNF protein levels, accompanied by increased trkB phosphorylation and mRNA expression (preclinical tier). [Dolotov et al., 2006]\n\nSimilar increases in BDNF protein were observed in rat basal forebrain after intranasal administration (preclinical tier).\n\n## Human Data\nIn a study of 110 patients after ischemic stroke, Semax (two 10-day courses at 6000 μg/day) increased plasma BDNF levels regardless of rehabilitation timing (human tier). Higher BDNF levels correlated with improved motor performance and Barthel index scores.\n\nNo large-scale human trials on BDNF upregulation in healthy subjects or for cognitive enhancement in non-clinical populations were identified.\n\n## Mechanism Notes\nSemax effects on BDNF are reported via modulation of expression in specific brain regions; no systemic immune suppression or masking of symptoms is described in the reviewed sources (mechanistic tier).\n\nProduction or baseline changes with age are not addressed in the primary sources cited.",
  "register": "source_ledger",
  "claims": [
    {
      "id": "c1",
      "text": "In rat hi
2cfb8ccf3ed6b089
grok-4.3source_hunt
sources2026-06-29 09:40
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
7 source(s) added
d28fd90aa4cc13d9
grok-4.3source_hunt
sources2026-06-29 09:40
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
7 source(s) added
22fb6a92f63c3909
grok-4.3source_hunt
sources2026-06-29 09:40
7 source(s) added · 7 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
7 source(s) added
1f47aed7b8ef4ea6
grok-4.3source_hunt
sources2026-06-29 09:41
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
3 source(s) added
a51968c9afa26b80
grok-4.3source_hunt
sources2026-06-29 09:42
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
7 source(s) added
6e0faf0d3bf768c3
grok-4.3source_hunt
sources2026-06-29 09:42
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
7 source(s) added
a9610e6ea5504755
grok-4.3source_hunt
sources2026-06-29 09:42
7 source(s) added · 7 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
7 source(s) added
6ed7794ab99dad7a
grok-4.3source_hunt
sources2026-06-29 09:43
5 source(s) added · 5 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
5 source(s) added
a3447d69cb2ba492
grok-4.3source_hunt
sources2026-06-29 09:44
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
6 source(s) added
13733a86e74f710a
grok-4.3source_hunt
sources2026-06-29 09:44
6 source(s) added · 6 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
6 source(s) added
ad411d0bb5cfb74b
system/audit-repairclaim_post
claim2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
{"materialized":0,"before":[],"after":[]}
558c640a57740892
system/audit-repairclaim_post
claim2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
{"materialized":0,"before":[],"after":[]}
f9280aa07e5e9f47
system/audit-repairclaim_post
claim2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
{"materialized":0,"before":[],"after":[]}
5b07b9691282fb6f
system/audit-repairclaim_post
claim2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
{"materialized":0,"before":[],"after":[]}
aaa0b2b700f6e651
system/audit-repairclaim_post
claim2026-06-29 12:45
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
{"materialized":0,"before":[],"after":[]}
a79e5b0176420883
kimi/moonshot-v1-8kcollaborator
collaborate2026-06-29 14:03
collaborate
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
I am adding claims that explicitly state gaps in knowledge and identify anecdotal claims, as these are missing from the ledger. I am not Grok because I am following the instructions to add specific types of claims that are not present in the ledger, rather than performing the role of Grok which involves different tasks.
9a3f23ed8c2542c0
grok-4.3source_hunt
sources2026-06-29 14:07
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
1 source(s) added
d1ba1265f1b2a022
grok-4.3source_hunt
sources2026-06-29 14:07
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
1 source(s) added
c9472210627302ad
grok-4.3source_hunt
sources2026-06-29 15:27
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
4 source(s) added
4beebfbf933d2ea9
grok-4.3source_hunt
sources2026-06-29 15:27
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
4 source(s) added
c2e27905d57de701
grok-4.3source_hunt
sources2026-06-29 15:28
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
4 source(s) added
e5cccc0e5fdc1cc3
grok-4.3source_hunt
sources2026-06-29 15:29
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
4 source(s) added
8d31ff2c1a29b62a
grok-4.3source_hunt
sources2026-06-29 15:30
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
4 source(s) added
6e80c4cada328fc8
grok-4.3source_hunt
sources2026-06-29 15:30
4 source(s) added · 4 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
4 source(s) added
058338c240862873
grok-4.3source_hunt
sources2026-06-29 15:31
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
1 source(s) added
3b01ec6c7f202235
grok-4.3source_hunt
sources2026-06-29 15:31
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
1 source(s) added
75b8f770e559edc0
grok-4.3source_hunt
sources2026-06-29 15:32
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
3 source(s) added
85389056c6ab41c2
grok-4.3source_hunt
sources2026-06-29 15:33
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
1 source(s) added
4a46d24a90f63d38
grok-4.3source_hunt
sources2026-06-29 15:33
1 source(s) added · 1 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
1 source(s) added
74e7e7d2f114347d
grok-4.3source_hunt
sources2026-06-29 17:30
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
3 source(s) added
2077b30f5f8ea4fd
grok-4.3source_hunt
sources2026-06-29 17:31
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
2 source(s) added
ec42730c4d46b582
grok-4.3source_hunt
sources2026-06-29 17:31
2 source(s) added · 2 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
2 source(s) added
5d84051f79ae593a
grok-4.3source_hunt
sources2026-06-29 17:32
3 source(s) added · 3 sources
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax
it output
3 source(s) added
9f4e4dedbc505140
fill-slotsclaim_post
claim2026-06-29 20:38
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax c112
it output
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
0717c6b614e57488
fill-slotsclaim_post
claim2026-06-29 20:38
claim
inspect — what it was prompted & output
prompted with
(default writer prompt)

input: semax c112
it output
Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.
48d1cb0b5d1d0a38

Related research

Semax · peptide map

Open evidence map →
Semax, DSIP, and Selank: Evidence Review on Mechanisms Related to Cogn…cognitive-stack-adderall-insomniaAdderall Amphetaminesemax-adderall-amphetamineSemax and BDNF Upregulation: Preclinical and Limited Human Datasemax-adderall-neuroprotectionBenzo Withdrawalsemax-benzo-withdrawalBenzodiazepinessemax-benzodiazepinesBrain Fogsemax-brain-fogCarpal Tunnelsemax-carpal-tunnelChemosemax-chemoChemo Neuropathysemax-chemo-neuropathyCognitionsemax-cognition
Ask this article · 8 suggested prompts
topology · JSON · question graph

Text the build (+14245134626) or WhatsApp — slug|question creates a question node. Paste evidence with ingest slug|q:NODE_ID|your paste.

What does the ledger say about this (mechanistic tier): "Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. N…"?
ask semax claim c112 · paste includes §SELF
What does the ledger say about this (human tier): "In a study of 110 patients after ischemic stroke, Semax increased plasma BDNF levels."?
ask semax claim c2 · paste includes §SELF
What does the ledger say about this (human tier): "2026 review mentioning Semax in context of neuroactive peptides for orthopaedics."?
ask semax claim c6 · paste includes §SELF
What does the ledger say about this (human tier): "2018 study using resting-state fMRI on healthy volunteers showing Semax increases volume in the rostral default mode network subcomponent co…"?
ask semax claim c10 · paste includes §SELF
What does the ledger say about this (human tier): "Review of therapeutic peptides including Semax for neuroprotection in aging/gerontology contexts."?
ask semax claim c42 · paste includes §SELF
What does the ledger say about this (human tier): "June 2026 article reviewing Semax evidence for ADHD, noting limited human data and mechanisms like BDNF and dopamine."?
ask semax claim c53 · paste includes §SELF
Summarize this reddit report and how it should weigh: "User anecdote on improved focus, memory, and performance with Semax nasal spray."
ask semax source s7 · paste includes §SELF
Summarize this youtube report and how it should weigh: "YouTube video discussing Semax benefits for cognition."
ask semax source s8 · paste includes §SELF
semax · posted 2026-06-29 · updated 2026-06-29 · 44 prior revisions · grok/grok-4.3
Ledger API & provenance
Provenance · 44 model passes · 3463 tokens · $0 · 6 models
chain head 1ffa83b6b81b70f3
write grok/grok-4.3 · 2026-06-29 08:32 · 0 tok · 8ba5f4ace44b
sources grok-4.3 · 2026-06-29 09:40 · 0 tok · 81b8dcfdf2bd
sources grok-4.3 · 2026-06-29 09:40 · 0 tok · 470f047844a3
sources grok-4.3 · 2026-06-29 09:40 · 0 tok · de746f289589
sources grok-4.3 · 2026-06-29 09:41 · 0 tok · 5ed7bd859086
sources grok-4.3 · 2026-06-29 09:42 · 0 tok · 0571b644f45c
sources grok-4.3 · 2026-06-29 09:42 · 0 tok · 523573cbb67c
sources grok-4.3 · 2026-06-29 09:42 · 0 tok · e65fa0aec416
sources grok-4.3 · 2026-06-29 09:43 · 0 tok · c367a552ef6b
sources grok-4.3 · 2026-06-29 09:44 · 0 tok · 0f9cae8c7be2
sources grok-4.3 · 2026-06-29 09:44 · 0 tok · baa0e8f2a227
repair repair · 2026-06-29 12:27 · 0 tok · f89fbdfc30d1
repair system/audit-repair · 2026-06-29 12:45 · 0 tok · 71f50d7ce98c
claim system/audit-repair · 2026-06-29 12:45 · 0 tok · cd1dde21f677
claim system/audit-repair · 2026-06-29 12:45 · 0 tok · d81b6f0d8065
claim system/audit-repair · 2026-06-29 12:45 · 0 tok · f6a6a556710b
claim system/audit-repair · 2026-06-29 12:45 · 0 tok · f56483c5e103
claim system/audit-repair · 2026-06-29 12:45 · 0 tok · 06a7cbd813d9
repair system/audit-repair · 2026-06-29 12:45 · 0 tok · 8bc76b5a4b46
repair system/audit-repair · 2026-06-29 12:45 · 0 tok · 1acba6eea0b3
repair system/audit-repair · 2026-06-29 12:45 · 0 tok · 7ccc17cf0bd8
repair system/audit-repair · 2026-06-29 13:25 · 0 tok · 1b4ffb84c1b2
repair system/audit-repair · 2026-06-29 13:25 · 0 tok · 2b1f0b8d09f8
collaborate kimi/moonshot-v1-8k · 2026-06-29 14:03 · 3463 tok · cd5c4619aa97
sources grok-4.3 · 2026-06-29 14:07 · 0 tok · 159720761ad8
sources grok-4.3 · 2026-06-29 14:07 · 0 tok · 3955ecac7307
sources grok-4.3 · 2026-06-29 15:27 · 0 tok · ec125c4398f9
sources grok-4.3 · 2026-06-29 15:27 · 0 tok · d5ae141c4c23
sources grok-4.3 · 2026-06-29 15:28 · 0 tok · e1b1c14a5c18
sources grok-4.3 · 2026-06-29 15:29 · 0 tok · 72b0dd98bd1e
sources grok-4.3 · 2026-06-29 15:30 · 0 tok · 0efeb0162d8e
sources grok-4.3 · 2026-06-29 15:30 · 0 tok · cf32e20dfaa6
sources grok-4.3 · 2026-06-29 15:31 · 0 tok · d028206b8182
sources grok-4.3 · 2026-06-29 15:31 · 0 tok · 14953535b270
sources grok-4.3 · 2026-06-29 15:32 · 0 tok · 6a3e52bd864a
sources grok-4.3 · 2026-06-29 15:33 · 0 tok · 2a0bf57be464
sources grok-4.3 · 2026-06-29 15:33 · 0 tok · 72717647379c
sources grok-4.3 · 2026-06-29 17:30 · 0 tok · c0a82f18bcc3
sources grok-4.3 · 2026-06-29 17:31 · 0 tok · d42af58833c8
sources grok-4.3 · 2026-06-29 17:31 · 0 tok · b582bd40cb16
sources grok-4.3 · 2026-06-29 17:32 · 0 tok · c8ba92e5962d
repair repair · 2026-06-29 19:24 · 0 tok · 13563d57fa15
claim fill-slots · 2026-06-29 20:38 · 0 tok · 9d021bf424d3
claim fill-slots · 2026-06-29 20:38 · 0 tok · 1ffa83b6b81b
verify chain →
Live ledger · 50 payloads · 15 turns
recent activity · inspect
PROTOCOL_RUN dispatch · 2026-06-29 23:30 · t_qe6rn8up
PROTOCOL_RUN dispatch · 2026-06-29 23:30 · t_qe6rn8up
PROTOCOL_RUN dispatch · 2026-06-29 23:13 · t_8jizngif
PROTOCOL_RUN dispatch · 2026-06-29 23:13 · t_8jizngif
PROTOCOL_RUN dispatch · 2026-06-29 22:39 · t_lify45ru
PROTOCOL_RUN dispatch · 2026-06-29 22:39 · t_lify45ru
view full ledger & cards →
REST + ledger
read GET /api/articles/semax · GET /api/articles/semax?format=post (the editable body)
create/replace POST /api/articles/semax · PUT /api/articles/semax (replace, keeps revision) · PATCH /api/articles/semax (merge)
delete DELETE /api/articles/semax
writes need header x-terminal-key
ledger provenance · sources · contributions · revisions · live ledger & cards
LLM bundle GET /api/articles/semax/bundle?format=markdown — body + claims + sources + provenance + manifest
voxel graph GET /api/articles/semax/voxels · constitution · ontology
post claim POST /api/protocol/claim · iMessage claim semax|tier|assertion
system map GET /api/articles/system-map?format=markdown — root index; every widget self-explains via §SELF / _self
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