Neuron-specific overexpression of human vasoactive ...“Neuron-specific overexpression of human vasoactive intestinal peptide receptor 2 in mice causes cognitive dysfunction and abnormal dendritic morphology in the ...”
Myopia pathogenesis and vasoactive intestinal peptide: Molecular mechanisms, experimental models, and clinical implications“This review summarizes current knowledge about myopia pathogenesis and the diverse factors involved, focusing on the molecular, genetic, pharmacological, and clinical findings regarding VIP/VIPR2 signaling in the eye. Evidence from animal models reveals a complex interaction between VIP and myopia, with VIP agonists/antagonists either protecting from or promoting myopia depending on model and dosa”
Vasoactive intestinal peptide associated 8-gene signature with prognostic and immune associations in melanoma“Vasoactive intestinal peptide (VIP) plays a multifaceted role in cancer biology, yet its prognostic and immunological implications in melanoma remain underexplored. This study aimed to construct a VIP-related gene signature for risk stratification and to explore its potential associations with the tumor immune microenvironment and drug sensitivity in melanoma.”
the whole object this page is drawn from, as JSON
{
"schema":"https://miscsubjects.com/schemas/jarticle.json",
"status":"published",
"slug":"vip",
"title":"vip",
"kind":"standard",
"summary":"Evidence is being populated by Grok web",
"created":"2026-06-29T16:56:19.771Z",
"body": [
"## Overview\nEvidence is being populated by Grok web search."
],
"facts": {
"converted_from":"markdown",
"original_updated":"2026-06-29T16:56:40.864Z",
"register":"standard",
"category":null
},
"sources": [
{
"id":"s1",
"type":"pubmed",
"url":"https://pubmed.ncbi.nlm.nih.gov/41498509/",
"title":"Elevated vasoactive intestinal peptide concentrations ...",
"quote":"Our findings suggest that elevated VIP concentrations are not predictive for a VIPoma and most patients with elevated VIP do not have a VIPoma. We recommend ...",
"summary":"Elevated VIP not predictive of VIPoma in most cases (2026 study).",
"author":"",
"publisher":"",
"date":"",
"claim_ids": [],
"found_by":"grok-4.3",
"extra": {},
"accessed_at":"2026-06-29T16:56:19.900Z",
"link_status":"ok",
"quote_status":"unverified",
"prev":"genesis",
"hash":"0e65c7116b8c72dffe4caefdb53ba44c2ad0a0a369b9c4db5a77fa96ade70a4a",
"quote_sha256":"94967164c3490090854eb2dfa1338fc2a368ac93de51842344d162eeedd1b961"
},
{
"id":"s2",
"type":"pubmed",
"url":"https://pubmed.ncbi.nlm.nih.gov/40118798/",
"title":"Serum Vasoactive Intestinal Peptide as a Novel Biomarker ...",
"quote":"Serum VIP levels are higher in patients with atrial fibrillation with LVAs , suggesting its potential as a noninvasive biomarker for detecting these areas.",
"summary":"Serum VIP as potential biomarker for left ventricular areas in AF (2025).",
"author":"",
"publisher":"",
"date":"",
"claim_ids": [],
"found_by":"grok-4.3",
"extra": {},
"accessed_at":"2026-06-29T16:56:19.900Z",
"link_status":"ok",
"quote_status":"unverified",
"prev":"0e65c7116b8c72dffe4caefdb53ba44c2ad0a0a369b9c4db5a77fa96ade70a4a",
"hash":"b1ff713ebc8d8a40f6f7583eab6d4aa8a148ee062b1969faeaec177845cd9dfc",
"quote_sha256":"7b4f666eb9b681093231ee4138ccdc7f5bf56d0808f01f86076d11b8e8ff6747"
},
{
"id":"s3",
"type":"pubmed",
"url":"https://pubmed.ncbi.nlm.nih.gov/42178419",
"title":"Vasoactive intestinal peptide advances chondrogenesis ...",
"quote":"VIP accelerated chondrogenic differentiation by inducing earlier mRNA and protein expression of chondrogenic markers and enhancing GAG production. In parallel, ...",
"summary":"VIP promotes chondrogenic differentiation (2026).",
"author":"",
"publisher":"",
"date":"",
"claim_ids": [],
"found_by":"grok-4.3",
"extra": {},
"accessed_at":"2026-06-29T16:56:19.900Z",
"link_status":"ok",
"quote_status":"unverified",
"prev":"b1ff713ebc8d8a40f6f7583eab6d4aa8a148ee062b1969faeaec177845cd9dfc",
"hash":"e42d5ebc952f1752ebbd67a3c44945bbee2bd886d2e5008e0883ebf6daabfe6c",
"quote_sha256":"fee7d6c5dc6c4e5ad66814f6b99cc9e2cc0501c5570a6ed52dfa5a732d06e651"
},
{
"id":"s4",
"type":"pubmed",
"url":"https://pubmed.ncbi.nlm.nih.gov/41554595/",
"title":"Neuron-specific overexpression of human vasoactive ...",
"quote":"Neuron-specific overexpression of human vasoactive intestinal peptide receptor 2 in mice causes cognitive dysfunction and abnormal dendritic morphology in the ...",
"summary":"Overexpression of VIP receptor 2 linked to cognitive issues in mice (2026).",
"author":"",
"publisher":"",
"date":"",
"claim_ids": [],
"found_by":"grok-4.3",
"extra": {},
"accessed_at":"2026-06-29T16:56:19.900Z",
"link_status":"ok",
"quote_status":"unverified",
"prev":"e42d5ebc952f1752ebbd67a3c44945bbee2bd886d2e5008e0883ebf6daabfe6c",
"hash":"47a8da63688bebbdd0728e79df033297e06afa5587c5c77eb8e4bf9d4cbd1aae",
"quote_sha256":"d09707c9ca25ca1fb8bbcc0648db1087f1adb18c450072a3126ca2ad41894885"
},
{
"id":"s5",
"type":"pubmed",
"url":"https://pubmed.ncbi.nlm.nih.gov/41571149/",
"title":"Neuronal VIP wires the intestinal epithelial cell function",
"quote":"show that neuron-derived vasoactive intestinal peptide (VIP ) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its ...",
"summary":"Neuronal VIP regulates gut epithelial and immune function (2026).",
"author":"",
"publisher":"",
"date":"",
"claim_ids": [],
"found_by":"grok-4.3",
"extra": {},
"accessed_at":"2026-06-29T16:56:19.900Z",
"link_status":"ok",
"quote_status":"unverified",
"prev":"47a8da63688bebbdd0728e79df033297e06afa5587c5c77eb8e4bf9d4cbd1aae",
"hash":"4d129353adef977f1e6631a881f93e42077f9e8fd09a09f92a33db847500c791",
"quote_sha256":"f223c80914e2278fe25bec2052f7e8a6797dbac973e28530f9c09e3298a15b55"
},
{
"id":"s6",
"type":"pubmed",
"url":"https://pubmed.ncbi.nlm.nih.gov/41421442/",
"title":"Myopia pathogenesis and vasoactive intestinal peptide: Molecular mechanisms, experimental models, and clinical implications",
"quote":"This review summarizes current knowledge about myopia pathogenesis and the diverse factors involved, focusing on the molecular, genetic, pharmacological, and clinical findings regarding VIP/VIPR2 signaling in the eye. Evidence from animal models reveals a complex interaction between VIP and myopia, with VIP agonists/antagonists either protecting from or promoting myopia depending on model and dosage, VIPR2 knockout mice developing spontaneous myopia, and VIP interacting with circadian rhythms and atropine signaling.",
"summary":"2026 review on VIP/VIPR2 role in myopia pathogenesis, models, and therapeutic potential.",
"author":"",
"publisher":"",
"date":"",
"claim_ids": [],
"found_by":"grok-4.3",
"extra": {},
"accessed_at":"2026-06-29T16:56:40.148Z",
"link_status":"ok",
"quote_status":"verified",
"prev":"4d129353adef977f1e6631a881f93e42077f9e8fd09a09f92a33db847500c791",
"hash":"79e7ca903c8fc602cb346e8145c25e603af003c024a6778f7ed6928c527d4c73",
"quote_sha256":"a31607d978139c6f1153c556fb4f7ec5f3b2c216a7d4f628b8da4899bf0105aa"
},
{
"id":"s7",
"type":"pubmed",
"url":"https://pubmed.ncbi.nlm.nih.gov/42216340/",
"title":"Vasoactive intestinal peptide associated 8-gene signature with prognostic and immune associations in melanoma",
"quote":"Vasoactive intestinal peptide (VIP) plays a multifaceted role in cancer biology, yet its prognostic and immunological implications in melanoma remain underexplored. This study aimed to construct a VIP-related gene signature for risk stratification and to explore its potential associations with the tumor immune microenvironment and drug sensitivity in melanoma.",
"summary":"2026 study develops VIP-related 8-gene prognostic signature in melanoma linked to immune microenvironment.",
"author":"",
"publisher":"",
"date":"",
"claim_ids": [],
"found_by":"grok-4.3",
"extra": {},
"accessed_at":"2026-06-29T16:56:40.148Z",
"link_status":"ok",
"quote_status":"verified",
"prev":"79e7ca903c8fc602cb346e8145c25e603af003c024a6778f7ed6928c527d4c73",
"hash":"fff2fb9576ec3b435eaac71b5f9b1e142e222ee649d72eed48cc774b84d95308",
"quote_sha256":"6c3e4c489879ff40a87675e27a9fb8b6febd665ba42d0599ec457bde45a3ffdc"
}
],
"type":"article",
"updated":"2026-10-08T11:49:50.954Z",
"version":1,
"hash":"c9ade82b198acc40adf53fd4464d7c2217c75b982887b6d722b708b4fdad7d5e",
"styling": {
"scope":"shared",
"how":"no value on the page is set by hand: each comes from this theme, and each theme value becomes the CSS variable named beside it. PATCH https://miscsubjects.com/api/jarticles/theme changes them.",
"widget_style": {
"what":"every widget may carry style: {…}; these are the only keys it reads",
"rotate":"degrees, a number",
"offset_x":"pixels, a number",
"offset_y":"pixels, a number",
"pulse":"true to pulse"
},
"theme": {
"color": {
"page_bg":"#f5f5f7",
"sheet_bg":"#ffffff",
"ink":"#1d1d1f",
"soft":"#424245",
"muted":"#6e6e73",
"dim":"#86868b",
"line":"#d2d2d7",
"accent":"#0071e3",
"accent_soft":"rgba(0,113,227,0.08)",
"link":"#0066cc",
"selection":"rgba(0,113,227,0.18)",
"widget_bg":"#f5f5f7",
"widget_border":"#d2d2d7",
"card_bg":"#ffffff",
"code_bg":"#f5f5f7",
"json_bg":"#161b19",
"json_ink":"#e6e1d4",
"json_key":"#7fd3c3",
"json_string":"#e9c46a",
"json_number":"#f4a261",
"json_bool":"#c792ea",
"json_null":"#928d7e",
"json_punct":"#6b6759",
"json_bar":"#0e1512",
"kind_badge_bg":"#0e6e60",
"kind_badge_ink":"#ffffff"
},
"color_dark": {
"page_bg":"#000000",
"sheet_bg":"#1d1d1f",
"ink":"#f5f5f7",
"soft":"#d2d2d7",
"muted":"#a1a1a6",
"dim":"#86868b",
"line":"#424245",
"accent":"#2997ff",
"accent_soft":"rgba(41,151,255,0.12)",
"link":"#2997ff",
"selection":"rgba(41,151,255,0.25)",
"widget_bg":"#2c2c2e",
"widget_border":"#424245",
"card_bg":"#1d1d1f",
"code_bg":"#2c2c2e",
"json_bg":"#0a0d0c",
"json_ink":"#e6e1d4",
"json_key":"#7fd3c3",
"json_string":"#e9c46a",
"json_number":"#f4a261",
"json_bool":"#c792ea",
"json_null":"#757062",
"json_punct":"#5d665f",
"json_bar":"#060807",
"kind_badge_bg":"#4fc1ab",
"kind_badge_ink":"#0b0f0d"
},
"font": {
"display":"-apple-system,BlinkMacSystemFont,\"SF Pro Display\",\"SF Pro Text\",\"Helvetica Neue\",Helvetica,Arial,sans-serif",
"body":"-apple-system,BlinkMacSystemFont,\"SF Pro Display\",\"SF Pro Text\",\"Helvetica Neue\",Helvetica,Arial,sans-serif",
"mono":"ui-monospace,SFMono-Regular,\"SF Mono\",Menlo,Consolas,monospace",
"google_fonts":""
},
"size": {
"body":"17px",
"small":"17px",
"eye":"17px",
"lead":"17px",
"h1":"52px",
"h2":"34px",
"h3":"22px",
"byline":"17px",
"h1_measure":"none",
"code":"17px",
"json":"17px",
"widget_title":"17px"
},
"leading": {
"body":"1.7",
"head":"1.18",
"lead":"1.5",
"json":"1.6"
},
"weight": {
"display":"700",
"head":"700",
"body":"400",
"strong":"700",
"eye":"700"
},
"tracking": {
"eye":"0.14em",
"display":"-0.03em",
"body":"-0.006em",
"badge":"0.08em"
},
"layout": {
"sheet_width":"1000px",
"text_width":"880px",
"gutter":"16px",
"sheet_padding":"56px 64px 64px",
"sheet_padding_mobile":"24px 18px 40px",
"sheet_margin":"28px auto 72px",
"block_gap":"1.15em",
"widget_gap":"28px",
"grid_gap":"14px"
},
"border": {
"sheet":"0px solid",
"sheet_radius":"30px",
"widget":"1px solid",
"widget_radius":"24px",
"card_radius":"24px",
"badge_radius":"999px",
"rule":"1px solid",
"code_radius":"18px",
"accent_bar":"3px"
},
"shadow": {
"sheet":"0 1px 1px rgba(0,0,0,.02),0 6px 26px rgba(0,0,0,.05)",
"widget":"none",
"card_hover":"0 10px 28px -16px rgba(28,27,23,0.35)"
},
"motion": {
"hover":"160ms ease"
}
}
},
"page":"https://miscsubjects.com/a/vip",
"json":"https://miscsubjects.com/a/vip.json",
"markdown":"https://miscsubjects.com/a/vip.md",
"theme":"https://miscsubjects.com/article-theme.json",
"calls": [
{
"what":"this article as a page (no key)",
"method":"GET",
"url":"https://miscsubjects.com/a/vip",
"headers": {}
},
{
"what":"this article as its object (no key)",
"method":"GET",
"url":"https://miscsubjects.com/a/vip.json",
"headers": {}
},
{
"what":"this article as Markdown (no key)",
"method":"GET",
"url":"https://miscsubjects.com/a/vip.md",
"headers": {}
},
{
"what":"the object with its hash, drafts too",
"method":"GET",
"url":"https://miscsubjects.com/api/jarticles/vip",
"headers": {
"x-sheets-key":"$(cat /Users/cyrusmassoumi/.misc-sheets-key)"
}
},
{
"what":"one piece and that piece’s hash",
"method":"GET",
"url":"https://miscsubjects.com/api/jarticles/vip/at?path=facts",
"headers": {
"x-sheets-key":"$(cat /Users/cyrusmassoumi/.misc-sheets-key)"
}
},
{
"what":"grep: every key or value that matches, with the path to change it",
"method":"GET",
"url":"https://miscsubjects.com/api/jarticles/vip/grep?q=owner",
"headers": {
"x-sheets-key":"$(cat /Users/cyrusmassoumi/.misc-sheets-key)"
}
},
{
"what":"change pieces (set, merge, delete, append, insert, move); if-match is the hash",
"method":"PATCH",
"url":"https://miscsubjects.com/api/jarticles/vip",
"headers": {
"x-sheets-key":"$(cat /Users/cyrusmassoumi/.misc-sheets-key)",
"content-type":"application/json",
"if-match":"<hash from the read>"
},
"body": {
"ops": [
{
"op":"set",
"path":"facts.example",
"value":1
}
]
}
},
{
"what":"replace the whole object",
"method":"PUT",
"url":"https://miscsubjects.com/api/jarticles/vip",
"headers": {
"x-sheets-key":"$(cat /Users/cyrusmassoumi/.misc-sheets-key)",
"content-type":"application/json",
"if-match":"<hash>"
},
"body": {
"slug":"vip",
"title":"…"
}
},
{
"what":"fetch every source, hash what came back and check the quote is in it",
"method":"POST",
"url":"https://miscsubjects.com/api/jarticles/vip/verify",
"headers": {
"x-sheets-key":"$(cat /Users/cyrusmassoumi/.misc-sheets-key)",
"content-type":"application/json"
},
"body": {}
},
{
"what":"an Obsidian-style command",
"method":"POST",
"url":"https://miscsubjects.com/api/jarticles/cli",
"headers": {
"x-sheets-key":"$(cat /Users/cyrusmassoumi/.misc-sheets-key)",
"content-type":"application/json"
},
"body": {
"command":"backlinks",
"file":"vip"
}
}
]
}